Skin cosmetic composition

Abstract

To provide a selective bactericide that exhibits superior bactericidal effects on Propionibacterium acnes while limiting bactericidal effects on Staphylococcus epidermidis.SOLUTION: Provided is a skin cosmetic composition comprising: (A) at least one selected from alkane diols having 8 to 12 carbon atoms and alkyl glyceryl ethers with alkyl groups having 8 to 12 carbon atoms; and (B) at least one nonionic surfactant.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a skin cosmetic composition.

Background Art

[0002] In recent years, as acne care, it is known that reducing acne bacteria, which are factors causing acne deterioration, and maintaining a large amount of Staphylococcus epidermidis on the skin is effective (see, for example, Non-Patent Document 1). As an external preparation composition for acne, for example, an external preparation composition for acne containing isopropylmethylphenol has been proposed (see, for example, Patent Document 1).

[0003] However, conventional external preparation compositions for acne including Patent Document 1 contain isopropylmethylphenol, which has a broad antibacterial spectrum as a normal bactericidal component. Therefore, there is a concern that not only acne bacteria but also Staphylococcus epidermidis are sterilized. In addition, normal bactericides such as isopropylmethylphenol also have concerns about irritation to sensitive skin.

[0004] Therefore, it is desired to provide a skin cosmetic composition that has an excellent bactericidal effect against acne bacteria while suppressing the bactericidal effect against Staphylococcus epidermidis.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Non-Patent Documents

[0006]

Non-Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0007] The present invention aims to solve the above-mentioned conventional problems and achieve the following objectives. That is, the present invention aims to provide a skin cosmetic composition that has an excellent bactericidal effect against acne bacteria while suppressing the bactericidal effect against Staphylococcus epidermidis.

Means for Solving the Problems

[0008] The skin cosmetic composition of the present invention contains (A) one or more selected from alkanediols having 8 to 12 carbon atoms and alkyl glyceryl ethers having 8 to 12 carbon atoms in the alkyl group, and (B) one or more nonionic surfactants selected from the following (B1) to (B6). (B1) Polyoxyethylene hydrogenated castor oil with an average addition mole number of ethylene oxide of 65 or more and 100 or less (B2) Polyglycerin monofatty acid ester having 8 to 18 carbon atoms derived from fatty acids and an average degree of polymerization of glycerin of 1 to 10 (B3) Polyoxyethylene sorbitan fatty acid ester having 12 to 18 carbon atoms derived from fatty acids and an average addition mole number of ethylene oxide of 5 to 30 (B4) Polyoxyethylene alkyl ether having 12 to 18 carbon atoms in the alkyl group and an average addition mole number of ethylene oxide of 5 to 30 (B5) Polyethylene glycol fatty acid ester having 12 to 18 carbon atoms derived from fatty acids and an average addition mole number of ethylene oxide of 5 to 30 (B6) Polyoxyethylene sorbit mono-fatty acid ester having 12 to 18 carbon atoms derived from fatty acids and an average addition mole number of ethylene oxide of 4 to 30

[0009] The present invention is based on the findings of the present inventor, and the means for solving the above problems are as follows. <1> (A) One or more selected from alkanediols having 8 to 12 carbon atoms and alkyl glyceryl ethers having 8 to 12 carbon atoms in the alkyl group, (B) One or more nonionic surfactants selected from the following (B1) to (B6), and a skin cosmetic composition characterized by containing the same. (B1) Polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 65 or more and 100 or less (B2) Polyglycerol monofatty acid ester having 8 to 18 carbon atoms derived from fatty acids and an average degree of polymerization of glycerin of 1 to 10 (B3) Polyoxyethylene sorbitan fatty acid ester having 12 to 18 carbon atoms derived from fatty acids and an average addition mole number of ethylene oxide of 5 to 30 (B4) Polyoxyethylene alkyl ether having 12 to 18 carbon atoms in the alkyl group and an average addition mole number of ethylene oxide of 5 to 30 (B5) Polyethylene glycol fatty acid ester having 12 to 18 carbon atoms derived from fatty acids and an average addition mole number of ethylene oxide of 5 to 30 (B6) Polyoxyethylene sorbit mono-fatty acid ester having 12 to 18 carbon atoms derived from fatty acids and an average addition mole number of ethylene oxide of 4 to 30 <2> The skin cosmetic composition according to <1>, wherein the mass ratio [(A) / (B)] of the content of the component (A) to the content of the component (B) is 0.37 or more and 1 or less. <3> The content of the component (A) is 0.05% by mass or more and 0.4% by mass or less with respect to the total amount of the skin cosmetic composition, The skin cosmetic composition according to <1> or <2>, wherein the content of the component (B) is 0.3% by mass or more and 4.0% by mass or less with respect to the total amount of the skin cosmetic composition. <4> The skin cosmetic composition according to any one of <1> to <3>, which contains one or more selected from (C) panthenol, pantothenyl ethyl ether, and pantothenic acid or a salt thereof. <5> The skin cosmetic composition according to <4>, wherein the content of the component (C) is 0.3% by mass or more and 1.0% by mass or less based on the total amount of the skin cosmetic composition. <6> The skin cosmetic composition according to any one of <1> to <5>, which is of the non-rinse-off type. <7> The skin cosmetic composition according to any one of <1> to <6>, which is a cream preparation.

Effects of the Invention

[0010] According to the present invention, it is possible to provide a skin cosmetic composition that has an excellent bactericidal effect against acne bacteria while suppressing the bactericidal effect against Staphylococcus epidermidis.

Modes for Carrying Out the Invention

[0011] (Skin Cosmetic Composition) The skin cosmetic composition of the present invention contains (A) one or more selected from alkanediols having 8 to 12 carbon atoms and alkyl glyceryl ethers having an alkyl group with 8 to 12 carbon atoms, and (B) one or more nonionic surfactants selected from the following (B1) to (B6), and optionally contains (C) one or more selected from panthenol, pantothenyl ethyl ether, and pantothenic acid or a salt thereof, and other components. (B1) Polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 65 or more and 100 or less (B2) Polyglycerol monofatty acid ester having 8 to 18 carbon atoms derived from a fatty acid and an average degree of polymerization of glycerin of 1 or more and 10 or less (B3) Polyoxyethylene sorbitan fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average addition mole number of ethylene oxide of 5 or more and 30 or less (B4) A polyoxyethylene alkyl ether in which the alkyl group has 12 to 18 carbon atoms and the average number of moles of ethylene oxide added is 5 to 30 (B5) A polyethylene glycol fatty acid ester in which the fatty acid has 12 to 18 carbon atoms and the average number of moles of ethylene oxide added is 5 to 30 (B6) A polyoxyethylene sorbitol mono-fatty acid ester in which the fatty acid has 12 to 18 carbon atoms and the average number of moles of ethylene oxide added is 4 to 30

[0012] In this specification, "one or more selected from (A) an alkanediol having 8 to 12 carbon atoms and an alkyl glyceryl ether having an alkyl group with 8 to 12 carbon atoms" may be referred to as "(A)" or "(A) component", "one or more nonionic surfactants selected from (B) (B1) to (B6)" may be referred to as "(B)" or "(B) component", "polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 65 or more and 100 or less" may be referred to as "(B1)" or "(B1) component", "polyglycerol monofatty acid ester having 8 to 18 carbon atoms derived from a fatty acid and an average degree of polymerization of glycerol of 1 or more and 10 or less" may be referred to as "(B2)" or "(B2) component", "polyoxyethylene sorbitan fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average addition mole number of ethylene oxide of 5 or more and 30 or less" may be referred to as "(B3)" or "(B3) component", "polyoxyethylene alkyl ether having an alkyl group with 12 to 18 carbon atoms and an average addition mole number of ethylene oxide of 5 or more and 30 or less" may be referred to as "(B4)" or "(B4) component", "polyethylene glycol fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average addition mole number of ethylene oxide of 5 or more and 30 or less" may be referred to as "(B5)" or "(B5) component", "polyoxyethylene sorbit mono-fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average addition mole number of ethylene oxide of 4 or more and 30 or less" may be referred to as "(B6)" or "(B6) component", and "one or more selected from (C) panthenol, panthenyl ethyl ether, and pantothenic acid or a salt thereof" may be referred to as "(C)" or "(C) component". In addition, in this specification, suppressing the bactericidal effect against Staphylococcus epidermidis means that ΔLog described below is less than 2, and excellent bactericidal effect against acne bacteria means that ΔLog described below is 2 or more.

[0013] <(A) One or more selected from alkanediols having 8 to 12 carbon atoms and alkyl glyceryl ethers having an alkyl group with 8 to 12 carbon atoms> The component (A) imparts good bactericidal power to the skin cosmetic composition.

[0014] - Alkanediol having 8 to 12 carbon atoms - The alkanediol having 8 to 12 carbon atoms is not particularly limited and can be appropriately selected according to the purpose. From the viewpoint of good bactericidal power, an alkanediol having 8 to 10 carbon atoms is preferable.

[0015] Specific examples of the alkanediol having 8 to 10 carbon atoms include 1,2-octanediol and 1,2-decanediol. These may be used alone or in combination of two or more.

[0016] The alkanediol having 8 to 12 carbon atoms may be appropriately synthesized or a commercially available product may be used. Commercially available products of the alkanediol having 8 to 12 carbon atoms include, for example, Hydrolite CG (1,2-octanediol, manufactured by Daedal Industrial Co., Ltd.), 1,2-Decanediol (1,2-decanediol, manufactured by Tokyo Chemical Industry Co., Ltd.), 1,8-octanediol (C8, manufactured by Tokyo Chemical Industry Co., Ltd.), 1,2-nonanediol (C9, manufactured by Tokyo Chemical Industry Co., Ltd.), 1,9-nonanediol (C9, manufactured by Tokyo Chemical Industry Co., Ltd.), 1,10-decanediol (C10, manufactured by Fujifilm Wako Pure Chemical Corporation), etc.

[0017] - Alkyl glyceryl ether having an alkyl group with 8 to 12 carbon atoms - As the alkyl glyceryl ether having 8 to 12 carbon atoms in the alkyl group, there is no particular limitation and it can be appropriately selected according to the purpose. However, from the viewpoint of good bactericidal power, an alkyl glyceryl ether having 8 to 10 carbon atoms in the alkyl group is preferable.

[0018] Specific examples of the alkyl glyceryl ether having 8 to 10 carbon atoms in the alkyl group include ethylhexyl glycerin and the like.

[0019] As the alkyl glyceryl ether having 8 to 12 carbon atoms in the alkyl group, those synthesized as appropriate may be used, or commercially available products may be used. Examples of commercially available products of the alkyl glyceryl ether having 8 to 12 carbon atoms in the alkyl group include, for example, under the trade name, HIDAL-181 (ethylhexyl glycerin, manufactured by Daedal Industrial Co., Ltd.) and the like.

[0020] The content of the component (A) is not particularly limited and can be appropriately selected according to the purpose. However, from the viewpoint of good selective bactericidal effect (high bactericidal power against acne bacteria and the effect of suppressing bactericidal power against Staphylococcus epidermidis), it is preferably 0.01% by mass or more and 0.5% by mass or less, more preferably 0.05% by mass or more and 0.4% by mass or less, based on the total amount of the skin cosmetic composition. When the content of the component (A) is 0.01% by mass or more based on the total amount of the skin cosmetic composition, the bactericidal power against acne bacteria becomes good. When the content of the component (A) is 0.5% by mass or less based on the total amount of the skin cosmetic composition, the effect of suppressing the bactericidal power against Staphylococcus epidermidis becomes good.

[0021] <One or more nonionic surfactants selected from (B)(B1) to (B6)> The component (B) imparts a good selective bactericidal effect to the skin cosmetic composition.

[0022] The component (B) is at least one nonionic surfactant selected from the following components (B1) to (B6). (B1) Polyoxyethylene hydrogenated castor oil with an average added mole number of ethylene oxide of 65 or more and 100 or less (B2) Polyglycerin monofatty acid ester in which the fatty acid has 8 to 18 carbon atoms and the average degree of polymerization of glycerin is 1 to 10 (B3) Polyoxyethylene sorbitan fatty acid ester in which the fatty acid has 12 to 18 carbon atoms and the average added mole number of ethylene oxide is 5 to 30 (B4) Polyoxyethylene alkyl ether in which the alkyl group has 12 to 18 carbon atoms and the average added mole number of ethylene oxide is 5 to 30 (B5) Polyethylene glycol fatty acid ester in which the fatty acid has 12 to 18 carbon atoms and the average added mole number of ethylene oxide is 5 to 30 (B6) Polyoxyethylene sorbit monolaurate in which the fatty acid has 12 to 18 carbon atoms and the average added mole number of ethylene oxide is 4 to 30 Among these, from the viewpoint of achieving a good selective bactericidal effect, the components (B2), (B3), (B4), (B5) and (B6) are preferred, and the components (B5) and (B6) are more preferred.

[0023] -(B1) Polyoxyethylene hydrogenated castor oil with an average added mole number of ethylene oxide of 65 or more and 100 or less- The component (B1) is not particularly limited and can be appropriately selected according to the purpose. From the viewpoint of achieving a good selective bactericidal effect, polyoxyethylene hydrogenated castor oil with an average added mole number of ethylene oxide of 80 or more and 100 or less is preferred.

[0024] For the component (B1), those synthesized as appropriate may be used, or commercially available products may be used. Examples of commercially available products of the component (B1) include, for example, NIKKOL HCO-80 (polyoxyethylene hydrogenated castor oil, average number of moles of ethylene oxide added: 80), NIKKOL HCO-100 (PEG-100 hydrogenated castor oil, average number of moles of ethylene oxide added: 100) under the trade names (manufactured by Nikko Chemicals Co., Ltd.), etc.

[0025] -(B2) A polyglycerol mono-fatty acid ester in which the fatty acid has 8 to 18 carbon atoms and the average degree of polymerization of glycerin is 1 to 10. The component (B2) is not particularly limited and can be appropriately selected according to the purpose. From the viewpoint of obtaining a good selective bactericidal effect, a polyglycerol mono-fatty acid ester in which the fatty acid has 12 to 18 carbon atoms and the average degree of polymerization of glycerin is 1 to 10 is preferable.

[0026] As the component (B2), those synthesized as appropriate may be used, or commercially available products may be used. Examples of commercially available products of the component (B2) include, for example, under the trade names NIKKOL MGS-BV2 (Glyceryl Stearate, manufactured by Nikko Chemicals Co., Ltd.), NIKKOL Decaglyn 1-SVEX (Polyglyceryl-10 Stearate, manufactured by Nikko Chemicals Co., Ltd.), NIKKOL Decaglyn 1-LVEX (Polyglyceryl-10 Laurate, manufactured by Nikko Chemicals Co., Ltd.), Sansoft Q-81F-C (Polyglyceryl-6 Caprylate, manufactured by Taiyo Chemical Co., Ltd.), Sansoft Q-10Y-C (Polyglyceryl-10 Caprate (C10), manufactured by Taiyo Chemical Co., Ltd.), NIKKOL Decaglyn 1-M (Polyglyceryl-10 Myristate (C14), manufactured by Nikko Chemicals Co., Ltd.), NIKKOL Decaglyn 1-PVEX (Polyglyceryl-10 Palmitate (C16), manufactured by Nikko Chemicals Co., Ltd.), NIKKOL Decaglyn 1-OV (Polyglyceryl-10 Oleate (C18), manufactured by Nikko Chemicals Co., Ltd.), Sansoft Q-81F-C (Polyglyceryl-6 Caprate (C10), manufactured by Taiyo Chemical Co., Ltd.), NIKKOL Hexaglyn 1-M (Polyglyceryl-6 Myristate (C14), manufactured by Nikko Chemicals Co., Ltd.), SY Glister MO-5S (Polyglyceryl-6 Oleate (C18), manufactured by Sakamoto Yakuhin Kogyo Co., Ltd.), NIKKOL Hexaglyn 1-SV (Polyglyceryl-6 Stearate (C18), manufactured by Nikko Chemicals Co., Ltd.), Sansoft A-12E-C (Polyglyceryl-5 Laurate (C12), manufactured by Taiyo Chemical Co., Ltd.), Sansoft A-14E-C (Polyglyceryl-5 Myristate (C14), manufactured by Taiyo Chemical Co., Ltd.), Sansoft A-17E-C (Polyglyceryl-5 Oleate (C18), manufactured by Taiyo Chemical Co., Ltd.), Sansoft A-18E-C (Polyglyceryl-5 Stearate (C18), manufactured by Taiyo Chemical Co., Ltd.), Sansoft No.750-C (Glyceryl Laurate (C12), manufactured by Taiyo Chemical Co., Ltd.), NIKKOL MGM (Glyceryl Myristate (C14), manufactured by Nikko Chemicals Co., Ltd.), Sansoft O-30S-C (Glyceryl Oleate (C18), manufactured by Taiyo Chemical Co., Ltd.), and the like.

[0027] -(B3) A polyoxyethylene sorbitan fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average addition mole number of ethylene oxide of 5 to 30 The (B3) component is not particularly limited and can be appropriately selected according to the purpose. From the viewpoint of achieving a good selective bactericidal effect, a polyoxyethylene sorbitan fatty acid ester having 12 to 18 carbon atoms derived from a fatty acid and an average addition mole number of ethylene oxide of 5 to 20 is preferable.

[0028] As the (B3) component, those synthesized as appropriate may be used, or commercially available products may be used. Examples of commercially available products of the (B3) component include, under the trade name, Nonion OT-221R (polyoxyethylene sorbitan monooleate (20 E.O.), manufactured by NOF Corporation), NIKKOL TS-30V (polysorbate 65, manufactured by Nikko Chemicals Co., Ltd.), NIKKOL TS-106V (PEG-6 sorbitan stearate, manufactured by Nikko Chemicals Co., Ltd.), and the like.

[0029] -(B4) A polyoxyethylene alkyl ether having 12 to 18 carbon atoms in the alkyl group and an average addition mole number of ethylene oxide of 5 to 30 The (B4) component is not particularly limited and can be appropriately selected according to the purpose. From the viewpoint of achieving a good selective bactericidal effect, a polyoxyethylene alkyl ether having 12 to 18 carbon atoms in the alkyl group and an average addition mole number of ethylene oxide of 5 to 20 is preferable, and a polyoxyethylene alkyl ether having 12 to 18 carbon atoms in the alkyl group and an average addition mole number of ethylene oxide of 8 to 20 is more preferable.

[0030] As the (B4) component, those synthesized as appropriate may be used, or commercially available products may be used. Examples of commercially available products of the component (B4) include, for example, MONOPOL LAE7 (C12C14 coconut oil EO-5, manufactured by DONGNAM chemical), EMALEX 608 (Steareth-8), EMALEX 610 (Steareth-10), EMALEX 611 (Steareth-11), EMALEX 615 (Steareth-15), EMALEX 620 (Steareth-20), EMALEX 630 (Steareth-30) (the above are manufactured by Nippon Emulsion Co., Ltd.), etc.

[0031] -(B5) Polyethylene glycol fatty acid ester in which the fatty acid has 12 to 18 carbon atoms and the average number of moles of ethylene oxide added is 5 to 30- The component (B5) is not particularly limited and can be appropriately selected according to the purpose. From the viewpoint of good selective bactericidal effect, polyethylene glycol fatty acid ester in which the fatty acid has 12 to 18 carbon atoms and the average number of moles of ethylene oxide added is 5 to 11 is preferable, and polyethylene glycol fatty acid ester in which the saturated fatty acid has 12 to 18 carbon atoms and the average number of moles of ethylene oxide added is 5 to 11 is more preferable.

[0032] Specific examples of the component (B5) include polyethylene glycol monolaurate (average number of moles of EO added: 10), polyethylene glycol monooleate (average number of moles of EO added: 10), polyethylene glycol monooleate (average number of moles of EO added: 6), etc. Among these, polyethylene glycol monolaurate (average number of moles of EO added: 10) is preferable from the viewpoint of good bactericidal power against acne bacteria and good selective bactericidal effect.

[0033] For the component (B5), those synthesized appropriately may be used, or commercially available products may be used. Examples of commercially available products of the component (B5) include, for example, MYL-10 (polyethylene glycol monolaurate (10 EO), manufactured by Nikko Chemicals Co., Ltd.), MYO-10V (polyethylene glycol monooleate (10 EO), manufactured by Nikko Chemicals Co., Ltd.), MYO-6V (polyethylene glycol monooleate (6 EO), manufactured by Nikko Chemicals Co., Ltd.), etc., under their trade names.

[0034] -(B6) Polyoxyethylene sorbitol mono-fatty acid ester in which the fatty acid has 12 to 18 carbon atoms and the average number of moles of ethylene oxide added is 4 to 30. The component (B6) is not particularly limited and can be appropriately selected according to the purpose. From the viewpoint of obtaining a good selective bactericidal effect, polyoxyethylene sorbitol mono-fatty acid ester in which the fatty acid has 12 to 18 carbon atoms and the average number of moles of ethylene oxide added is 4 to 8 is preferred.

[0035] As the component (B6), those synthesized as appropriate may be used, or commercially available products may be used. Examples of commercially available products of the component (B6) include, for example, GL-1 (polyoxyethylene sorbitol monolaurate (6 EO), manufactured by Nikko Chemicals Co., Ltd.), etc., under their trade names.

[0036] The content of the component (B) is not particularly limited and can be appropriately selected according to the purpose. From the viewpoint of obtaining a good selective bactericidal effect, it is preferably 0.1% by mass or more and 5.0% by mass or less, more preferably 0.3% by mass or more and 4.0% by mass or less, based on the total amount of the skin cosmetic composition. When the content of the component (B) is 0.1% by mass or more based on the total amount of the skin cosmetic composition, the bactericidal power against acne bacteria becomes good. When the content of the component (B) is 5.0% by mass or less based on the total amount of the skin cosmetic composition, the inhibitory effect on the bactericidal power against Staphylococcus epidermidis becomes good.

[0037] <Mass ratio [(A) / (B)]> In the skin cosmetic composition of the present invention, from the viewpoint of achieving a good bactericidal effect against Staphylococcus epidermidis and good bactericidal activity against acne bacteria, the mass ratio [(A) / (B)] of the content of the component (A) to the content of the component (B) is preferably 0.04 or more and 1.7 or less, and more preferably 0.37 or more and 1.0 or less. When the mass ratio [(A) / (B)] is 0.04 or more, the bactericidal activity against acne bacteria becomes good. When the mass ratio [(A) / (B)] is 1.7 or less, the inhibitory effect on the bactericidal activity against Staphylococcus epidermidis becomes good.

[0038] <One or more selected from (C) panthenol, pantothenyl ethyl ether, and pantothenic acid or its salt> The component (C) imparts good bactericidal activity against acne bacteria to the skin cosmetic composition.

[0039] The component (C) is not particularly limited and can be appropriately selected according to the purpose. From the viewpoint of obtaining good bactericidal activity against acne bacteria, panthenol and pantothenyl ethyl ether are preferred.

[0040] As the component (C), those synthesized appropriately may be used, or commercially available products may be used. Examples of commercially available products of the component (C) include, for example, D-pantothenyl alcohol (panthenol, manufactured by BASF Japan Ltd.) under the trade name, pantothenic acid (Thecnical Grade, Contains Lactone) (pantothenic acid, manufactured by Toronto Research Chemicals Inc.), Sodium D-Pantothenate (sodium pantothenate, manufactured by Tokyo Chemical Industry Co., Ltd.), Calcium D-Pantothenate (calcium pantothenate, manufactured by Tokyo Chemical Industry Co., Ltd.), and the like.

[0041] The content of the component (C) is not particularly limited and can be appropriately selected according to the purpose. However, from the viewpoint of achieving good bactericidal power against acne bacteria, it is preferably 0.1% by mass or more and 1.0% by mass or less, more preferably 0.3% by mass or more and 1.0% by mass or less, based on the total amount of the skin cosmetic composition. When the content of the component (C) is 0.1% by mass or more based on the total amount of the skin cosmetic composition, the bactericidal power against acne bacteria becomes good. When the content of the component (C) is 1.0% by mass or less based on the total amount of the skin cosmetic composition, the bactericidal power against acne bacteria becomes good.

[0042] <Other components> In the skin cosmetic composition of the present invention, in addition to the components (A) to (C), other components can be blended as necessary within a range that does not impair the effects of the present invention. Examples of the other components include anti-inflammatory agents, vitamin agents other than the component (C), surfactants other than the component (B), preservatives, water-soluble polymers, oils, silicones, alcohols such as lower or higher alcohols, pH adjusters, antioxidants, sequestering agents, pigments, fragrances, cooling agents, moisturizing agents, amino acids, and the like. These may be used alone or in combination of two or more. As the other components, those synthesized appropriately may be used, or commercially available products may be used. The content of the other components in the skin cosmetic composition is not particularly limited and can be appropriately selected according to the purpose.

[0043] - Anti-inflammatory agent - The anti-inflammatory agent is not particularly limited and can be appropriately selected according to the purpose. For example, tranexamic acid, glycyrrhetinic acid, glycyrrhizic acid or a pharmaceutically acceptable derivative thereof or a salt thereof (for example, dipotassium glycyrrhizinate), licorice extract, steroid compound (hydrocortisone, prednisolone, methylprednisolone, clobetasone, betamethasone, dexamethasone, cortisone, flumethasone, beclomethasone, fluticasone or a pharmaceutically acceptable derivative thereof or a salt thereof), indomethacin, ibuprofen, ibuprofen piconol, bufexamac, ufenamate, piroxicam, ketoprofen, salicylic acid or a pharmaceutically acceptable derivative thereof or a salt thereof, dimethylisopropylazulene, toki extract, shikonin extract and the like can be mentioned.

[0044] -(C) component other than vitamins The vitamin agent other than the component (C) is not particularly limited and can be appropriately selected according to the purpose. For example, vitamin A, vitamin B6, vitamin C, vitamin E, vitamin B1, vitamin B2, vitamin B3, vitamin B12, biotin, folic acid and a pharmaceutically acceptable derivative thereof or a salt thereof, vitamin D, other vitamins and the like can be mentioned.

[0045] Examples of the vitamin A include retinol and a pharmaceutically acceptable derivative thereof or a salt thereof (for example, retinol palmitate, retinol acetate, retinol, retinal, retinoic acid, retinoid, etc.).

[0046] Examples of the vitamin B6 include pyridoxine and a pharmaceutically acceptable derivative thereof or a salt thereof (for example, pyridoxine, pyridoxal, etc.).

[0047] Examples of the vitamin C include ascorbic acid and pharmaceutically acceptable derivatives and salts thereof (e.g., ascorbic acid, sodium ascorbate, magnesium ascorbate phosphate, sodium 3-palmitate ascorbate phosphate, erythorbic acid, ascorbic acid 2-glucoside, ascorbyl palmitate, etc.).

[0048] Examples of the vitamin E include tocopherol and pharmaceutically acceptable derivatives and salts thereof (e.g., d-α-tocopherol, dl-α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, mixed tocopherol, α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, vitamin E acetate (tocopherol acetate), vitamin E nicotinate, vitamin E succinate, vitamin E linolenate, natural vitamin E, etc.).

[0049] Examples of the vitamin B1 include thiamine and pharmaceutically acceptable derivatives and salts thereof (e.g., thiamine hydrochloride, thiamine nitrate, etc.).

[0050] Examples of the vitamin B2 include riboflavin and pharmaceutically acceptable derivatives and salts thereof (e.g., riboflavin phosphate, sodium riboflavin phosphate, riboflavin butyrate, sodium flavin adenine dinucleotide, etc.).

[0051] Examples of the vitamin B3 include nicotinic acid and pharmaceutically acceptable derivatives and salts thereof (nicotinamide, benzyl nicotinate, etc.).

[0052] Examples of the vitamin B12s include cobalamin and derivatives thereof and pharmaceutically acceptable derivatives and salts thereof (e.g., cyanocobalamin, mecobalamin, hydroxocobalamin hydrochloride, etc.).

[0053] Examples of the vitamin Ds include calciferol and pharmaceutically acceptable derivatives and salts thereof (e.g., ergocalciferol, cholecalciferol, etc.).

[0054] Examples of the other vitamins include hesperidin, carnitine, ferulic acid, γ-oryzanol, orotic acid, rutin, eriocitrin, inositol, and pharmaceutically acceptable derivatives and salts thereof.

[0055] - Surfactants other than component (B) The surfactant other than component (B) is not particularly limited and can be appropriately selected according to the purpose. Examples thereof include ionic surfactants. Examples of the ionic surfactant include N-coconut oil fatty acid acyl-DL-alanine triethanolamine solution.

[0056] - Preservative The preservative may or may not be contained in the skin cosmetic composition. From the viewpoint of the selective bactericidal effect, the specific content of the preservative is preferably 0.09% by mass or less, more preferably 0.01% by mass or less, and still more preferably 0.001% by mass or less based on the total amount of the skin cosmetic composition.

[0057] - Cooling agent The cooling agent is not particularly limited and can be appropriately selected according to the purpose. Examples thereof include l-menthol, camphor, borneol or related substances thereof, perilla oil, eucalyptus oil, peppermint oil, spearmint oil, etc.

[0058] - Humectant The humectant is not particularly limited and can be appropriately selected according to the purpose. For example, polyhydric alcohols (such as glycerin, 1,3-butylene glycol, 1,2-pentanediol, etc.), sugar alcohols (such as sorbitol, etc.), hyaluronic acid or its derivatives, heparin-like substances, high molecular compounds (such as collagen, chitosan, etc.), amino acids, natural moisturizing factors (such as sodium lactate, urea, etc.), ceramides, vegetable oils (such as olive oil, etc.), plant extracts (such as soybean extract, chamomile extract, aloe extract, etc.) and the like can be mentioned.

[0059] - Amino acids - The amino acids are not particularly limited and can be appropriately selected according to the purpose. For example, glutamic acid, aspartic acid, glycine, alanine, serine, aminoethylsulfonic acid (taurine), and pharmaceutically acceptable salts thereof (such as ephedrine hydrochloride, methylphenolamine hydrochloride, etc.) and the like can be mentioned.

[0060] As the other components, in addition to those described above, hydrocarbons such as petrolatum, paraffin, liquid paraffin, squalane, ceresin, gelled hydrocarbon, and microcrystalline wax; higher fatty acids such as stearic acid, isostearic acid, myristic acid, palmitic acid, oleic acid, and behenic acid; higher fatty alcohols such as cetyl alcohol, stearyl alcohol, and behenyl alcohol; fatty acid ester oils such as isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, and diisopropyl adipate; triglyceride fatty acid esters such as glyceryl triisooctanoate and glyceryl tri(caprylyl / caprate); polyhydric alcohols such as propylene glycol and polyethylene glycol; organic solvents such as acetone, methyl ethyl ketone, and ethyl acetate; pH adjusters such as diisopropanolamine, triethanolamine, lauric acid diethanolamide, potassium hydroxide, sodium hydroxide, hydrochloric acid, citric acid, sodium citrate, potassium dihydrogen phosphate, and disodium hydrogen phosphate; chelating agents such as disodium edetate, ethylenediaminetetraacetate, edetate, pyrophosphate, hexametaphosphate, citric acid, tartaric acid, and gluconic acid; preservatives such as parabens (methylparaben, ethylparaben, butylparaben), boric acid, and borax; cellulose derivatives such as hydroxypropyl cellulose, hydroxypropyl methylcellulose, hydroxyethyl cellulose, carmellose, croscarmellose, ethyl cellulose, and methyl cellulose;Modified starches such as partially pregelatinized starch, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, crospovidone, polyethylene glycol, xanthan gum, carrageenan, sodium alginate, gum arabic, guar gum, tamarind gum, karaya gum, carob gum, tragacanth gum, locust bean gum, pullulan, gelatin, carboxyvinyl polymer, alkyl acrylate / methacrylate copolymer, sodium polyacrylate, hydroxyethyl acrylate / acryloyl dimethyl taurate cross-linked polymer, quince seed (membrillo), casein, dextrin, sodium pectate, dimethylacrylamide / acryloyl dimethyl taurate cross-linked polymer, dialkyldimethylammonium sulfate cellulose, bentonite, hectorite, magnesium aluminum silicate, laponite, silica anhydride and other thickeners; compounded fragrances such as citrus fragrance, floral fragrance, and rose fragrance; essential oils (natural fragrances) such as peppermint oil, eucalyptus oil, bergamot oil, rose oil, rosemary oil, lavender oil, and lemon oil; pearlescent agents such as ethylene glycol distearate, etc. can also be used.;

[0061] The pH of the skin cosmetic composition at 25°C is not particularly limited and can be appropriately selected according to the purpose. However, from the viewpoint of good bactericidal power against acne bacteria, 3.0 or more is preferable, and 3.5 or more is more preferable. Also, from the viewpoint of good skin irritation, 10 or less is preferable, and 9 or less is more preferable.; The measurement of the pH can be carried out, for example, based on the 18th revised Japanese Pharmacopoeia - General Test Methods (measurement temperature: 25°C).;

[0062] The viscosity of the skin cosmetic composition at 30°C is not particularly limited and can be appropriately selected according to the purpose. However, it is preferably 10 Pa·s or more and 200 Pa·s or less.;

[0063] The dosage form and properties of the skin cosmetic composition of the present invention are not particularly limited as long as they can be applied transdermally, and may be any of liquid, solid, semi-solid (gel, ointment, paste, foam, etc.). Further, the embodiment may be in any form of a topical skin pharmaceutical, a quasi-drug for external use on the skin, a skin cleanser (such as a facial cleanser), a skin cosmetic (lotion, moisturizer, whitening agent, etc.).

[0064] The dosage form of the skin cosmetic composition of the present invention is not particularly limited and can be appropriately selected according to the purpose. For example, ointment, cream, lotion, gel, emulsion, liquid, patch, mist, spray that sprays in a foamy state, aerosol that sprays in a misty, powdery, foamy or paste state, pack, body shampoo, hair shampoo, rinse, etc. can be mentioned. Among these, ointment, cream, lotion, gel, aerosol, spray, emulsion, and pack are preferable, and cream, lotion, and emulsion are more preferable. The emulsified state of creams, emulsions, etc. is not particularly limited and may be any of water-in-oil (W / O), oil-in-water (O / W), and multiple emulsions (W / O / W, O / W / O).

[0065] - Method for producing a skin cosmetic composition - The method for producing the skin cosmetic composition of the present invention is not particularly limited and can be appropriately selected according to the purpose. The component (A), the component (B), and, if necessary, the component (C), the other components, and purified water (formulated as the remaining amount so that the whole skin cosmetic composition is 100% by mass) can be mixed to obtain it.

[0066] The skin cosmetic composition may be prepared using an apparatus. The apparatus is not particularly limited and can be appropriately selected according to the purpose. For example, a stirring device equipped with stirring blades having shear force and capable of mixing the whole can be mentioned. The stirring blades are not particularly limited and can be appropriately selected according to the purpose. For example, propeller, turbine, disperser, etc. can be mentioned.

[0067] - Use - There are no particular restrictions on the application site and method of use of the skin cosmetic composition, and it can be appropriately selected according to the purpose. For example, it can be used in the usual way on the whole body, face, hands, back, etc. There are no particular restrictions on the use of the skin cosmetic composition, and it can be appropriately selected according to the purpose. For example, it includes moisturizers such as lotion and cream for acne care. The skin cosmetic composition may be of a type that is not washed off after application.

Examples

[0068] The present invention will be specifically described below with reference to Examples and Comparative Examples, but the present invention is not limited to these Examples in any way. The content of each component described in the Examples and Comparative Examples is shown in "mass%", the total amount is 100 mass%, and all are values converted to pure components.

[0069] (Examples 1 to 23 and Comparative Examples 1 to 6) As shown in the compositions and contents of Examples 1 to 23 and Comparative Examples 1 to 6, each component was mixed to prepare each skin cosmetic composition.

[0070] For each skin cosmetic composition, the "bactericidal power" was evaluated and determined as follows. The results are shown in Tables 1 to 5 below.

[0071] <Evaluation of bactericidal power> The bactericidal power was evaluated using the two types of bacteria shown below. · Staphylococcus epidermidis: Staphylococcus epidermidis, NBRC 12993 · Cutibacterium acnes: Cutibacterium acnes, NBRC 107605 First, each bacterium was cultured on a plate agar medium. For the medium of Staphylococcus epidermidis, plate SCDLP agar medium (398 - 00265, manufactured by Shioya MS Co., Ltd.) was used, and for the medium of Cutibacterium acnes, plate GAM agar medium (05420, manufactured by Nissui Pharmaceutical Co., Ltd.) was used. Then, using 3° hard water, 1.0×10 7Each bacterial solution was prepared to have a concentration of bacteria / mL. 0.1 g of the prepared bacterial solution was added to 10 g of each skin cosmetic composition or 10 g of 3° hard water as a control to prepare a bacterial mixture, and the mixture was left to stand at 30°C for 6 hours. Next, 0.3 g of the bacterial mixture was suspended in 2.7 mL of SCDLP medium (398-00265, Shioya MS Co., Ltd.), and then serially diluted to an appropriate bacterial concentration. For the mixture containing Staphylococcus epidermidis, 1 mL of each serially diluted bacterial solution was evenly spread on an SCDLP agar plate medium, and aerobically cultured at 37°C for 1 to 2 days. For the mixture containing Propionibacterium acnes, 1 mL of each serially diluted bacterial solution was evenly spread on an GAM agar plate medium, and anaerobically cultured at 37°C for 2 to 3 days. After the culture, the number of colonies was counted and used as the viable cell count. The bactericidal activity of each sample was calculated as ΔLog value according to the following formula, and judged based on the following criteria. A grade of "△" or higher was considered to be acceptable. The number of samples was two, and the average value was used for the evaluation. (Formula) ΔLog=Log (viable bacteria count when using control)−Log (viable bacteria count when using each skin cosmetic composition) - Evaluation criteria (antibacterial effect against acne bacteria) - +++: ΔLog is 4.0 or more ++: ΔLog is 3 or more and less than 4.0 +: ΔLog is 2 or more and less than 3 -: ΔLog is less than 2 - Evaluation criteria (bactericidal activity against Staphylococcus epidermidis) - ++: ΔLog is 2 or more +: ΔLog is 1 or more and less than 2 -: ΔLog is less than 1 -Criteria (selective sterilization)- ◎◎: The bactericidal effect against P. acnes is rated as "+++" and the bactericidal effect against Staphylococcus epidermidis is rated as "-" ◎: The bactericidal effect against Propionibacterium acnes is rated as "++" and the bactericidal effect against Staphylococcus epidermidis is rated as "-" 〇: The bactericidal effect against P. acnes is rated as "+" and the bactericidal effect against Staphylococcus epidermidis is rated as "-" △: The bactericidal activity against Propionibacterium acnes is rated as "++" or "+", and the bactericidal activity against Staphylococcus epidermidis is rated as "+" ×: Evaluation of bactericidal activity against acne bacteria is "-", or evaluation of bactericidal activity against Staphylococcus epidermidis is "++"

[0072]

Table 1

[0073]

Table 2

[0074]

Table 3

[0075]

Table 4

[0076]

Table 5

[0077] Details of each component used in Examples 1 to 23 and Comparative Examples 1 to 6 are shown in Table 6 below.

[0078]

Table 6

[0079] (Formulation Examples 1 to 4) A skin cosmetic composition (cream) having the composition and content shown in Table 7 below was prepared in the same manner as in Example 1.

[0080]

Table 7

[0081] Details of each component used in Formulation Examples 1 to 4 are shown in Tables 8 to 9 below.

[0082]

Table 8

[0083]

Table 9

Industrial Applicability

[0084] Since the skin cosmetic composition can suppress the bactericidal effect against Staphylococcus epidermidis while having an excellent bactericidal effect against acne bacteria, it can be suitably used, for example, as a moisturizer such as a lotion or a cream for acne care.

Claims

1. (A) one or more selected from alkanediols having 8 to 12 carbon atoms and alkyl glyceryl ethers having an alkyl group having 8 to 12 carbon atoms, (B) one or more nonionic surfactants selected from the following (B1) to (B6): (B1) Polyoxyethylene hydrogenated castor oil having an average number of moles of ethylene oxide added of 65 to 100 (B2) Polyglycerol mono-fatty acid ester having 8 to 18 carbon atoms derived from fatty acids and having an average degree of polymerization of glycerol of 1 to 10 (B3) Polyoxyethylene sorbitan fatty acid ester having 12 to 18 carbon atoms derived from fatty acids and an average number of moles of ethylene oxide added of 5 to 30 (B4) Polyoxyethylene alkyl ether having an alkyl group with 12 to 18 carbon atoms and an average number of moles of ethylene oxide added of 5 to 30. (B5) Polyethylene glycol fatty acid ester having 12 to 18 carbon atoms derived from fatty acid and an average number of moles of ethylene oxide added of 5 to 30 (B6) Polyoxyethylene sorbitol mono fatty acid ester having 12 to 18 carbon atoms derived from fatty acids and an average number of moles of ethylene oxide added of 4 to 30

2. 2. The skin cosmetic composition according to claim 1, wherein the mass ratio [(A) / (B)] of the content of the component (A) to the content of the component (B) is 0.37 or more and 1 or less.

3. The content of the component (A) is 0.05% by mass or more and 0.4% by mass or less based on the total amount of the skin cosmetic composition, 3. The skin cosmetic composition according to claim 1, wherein the content of the component (B) is from 0.3% by mass to 4.0% by mass, based on the total amount of the skin cosmetic composition.

4. The skin cosmetic composition according to claim 1 or 2, comprising (C) one or more selected from panthenol, pantothenyl ethyl ether, and pantothenic acid or a salt thereof.

5. The skin cosmetic composition according to claim 4 , wherein the content of the component (C) is from 0.3% by mass to 1.0% by mass, based on the total amount of the skin cosmetic composition.

6. The skin cosmetic composition according to claim 1 or 2, which is a leave-on type.

7. The skin cosmetic composition according to claim 1 or 2, which is a cream.

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