Beverage comprising elastin and iron

Abstract

To suppress an unpleasant odor when an iron compound and collagen peptide or elastin peptide are formulated in an oral liquid composition.SOLUTION: The oral liquid composition comprises (A) an iron compound, (B) at least one peptide selected from the group consisting of collagen peptide and / or elastin peptide, and (C) at least one plant extract selected from the group consisting of lemon balm extract, Houttuynia cordata extract, artichoke extract and rosemary extract.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an oral liquid composition containing an iron compound, and is useful for the treatment of various diseases such as medicines, quasi-drugs, and foods. It can be used in the fields of [Background technology]

[0002] Although iron is an essential metal for the body, the intake of iron is low compared to the recommended intake, especially in women. It has been reported that people tend to be deficient in this nutrient. The recommended amount of iron for women is 10.5 mg. The iron intake of the elderly is 7.5 mg, which means that they are deficient in iron by about 3 mg per day (Non-Patent Document 1) As an efficient way to ingest iron through diet, drinks and supplements containing iron compounds are available. However, iron compounds react with other ingredients, impairing flavor and quality. (Patent Documents 1 and 2).

[0003] In recent years, drinks and supplements containing collagen peptides and elastin peptides have also become popular. Collagen is the main component of the dermis, ligaments, tendons, bones, cartilage, etc. Collagen peptides are proteins obtained from animals and fish. Elastin is found in the ligamentum nuchale, aorta, skin, and lungs. It is the main protein of fibers that is widely distributed in various tissues that require elasticity, such as Reference 3).

[0004] Elastin peptides are produced by hydrolyzing raw materials such as animal aortas and fish bulbs of arteries. In this way, collagen peptides and elastin peptides are obtained from pig and fish. Because it is obtained from protein, it has a distinctive unpleasant odor.

[0005] So far, we have developed a beverage with a good flavor that contains collagen hydrolysate, such as Job's tears extract. , safflower extract, apricot extract, and carrot extract. extract, royal jelly, one or more selected from vitamin B2 and vitamin B6 Contains two or more vitamins, dietary fiber, sugar, stevia, plum juice, and sodium L-aspartate. A beverage containing a blend of citric acid, an acidulant, and a fruit flavor has been reported (Patent Document 3 ). [Prior art documents] [Non-patent literature]

[0006] [Non-Patent Document 1] Food and Development Vol.55 No.6 P.41 [Non-patent document 2] Hiroki Ohara et al., Japanese Journal of Food Chemical Engineering, Vol. 56, No. 3, P. 137-145 (2009) [Non-patent document 3] Food and Development Vol.50 No.7 P.14 [Patent documents]

[0007] [Patent Document 1] Japanese Patent Application Laid-Open No. 2017-93397 [Patent Document 2] Japanese Patent Application Laid-Open No. 2000-279143 [Patent Document 3] Japanese Patent Application Publication No. 5-199855 Summary of the Invention [Problem to be solved by the invention]

[0008] The present inventors have discovered an oral liquid composition containing collagen peptides or elastin peptides. It was discovered that when an iron compound was added to the The purpose of the present invention is to provide a highly palatable oral liquid composition that can be taken daily and that suppresses this particular unpleasant odor. The purpose is to provide [Means for solving the problem]

[0009] After extensive research to solve this problem, we discovered that the incorporation of specific plant extracts can effectively prevent iron compounds from forming. Suppresses the unpleasant odor that occurs when substances are combined with collagen peptides or elastin peptides This has led to the completion of the present invention.

[0010] The present invention has been made based on these findings and has the following aspects. (1)(A) Iron compounds, (B) at least one selected from the group consisting of collagen peptides and elastin peptides; Species peptides, (C) Lemon balm extract, Houttuynia cordata extract, artichoke extract, and rosemary and at least one plant extract selected from the group consisting of an oral liquid composition (2) (A) The content of iron compounds is 0.0002 to 0.2 w / v% in terms of iron (1) The oral liquid composition according to (3) (B) The content of collagen peptide is 0.02 to 20 w / v% (1), or (2) The oral liquid composition according to (4) (B) The content of elastin peptide is 0.0002 to 2 w / v% (1) to (3) The oral liquid composition according to any one of (1) to (3). (5) (C) Lemon balm extract, Houttuynia cordata extract, artichoke extract, and The content of at least one plant extract selected from the group consisting of rosemary extract is 0.0 The oral liquid composition according to any one of (1) to (4), wherein the oral liquid composition is 0.02 to 2 w / v%. (6) Iron compounds include ferrous fumarate, ferric chloride, iron citrate, and ammonium iron citrate. , Sodium ferrous citrate, ferrous gluconate, ferrous lactate, ferrous pyrophosphate, pyrophosphate At least one selected from the group consisting of ferric iron, ferrous sulfate, and heme iron (1) (5) The oral liquid composition according to any one of (1) to (5). (7) The oral liquid composition according to any one of (1) to (6), having a pH of 2.5 to 4.5. (8) The oral liquid composition according to any one of (1) to (7), wherein the oral liquid composition is a liquid beverage. Composition, (9) The effect of combining iron compounds with collagen peptides or elastin peptides To combat unpleasant odors, lemon balm extract, Houttuynia cordata extract, artichoke extract, and rose extract By blending at least one plant extract selected from the group consisting of Mari extract How to suppress is. [Effects of the Invention]

[0011] According to the present invention, when an iron compound and a collagen peptide or an elastin peptide are combined, It has become possible to provide an oral liquid composition in which the characteristic unpleasant odor is suppressed. DETAILED DESCRIPTION OF THE INVENTION

[0012] In the present invention, the term "iron compound" refers to either a divalent iron compound or a trivalent iron compound. For example, ferrous fumarate, ferric chloride, iron citrate, ammonium iron citrate, citrate Sodium ferrous acid, ferrous gluconate, ferrous lactate, ferrous pyrophosphate, ferric pyrophosphate The iron content of iron compounds is high. As the amount of collagen peptides increases, the proportion of unpleasant odors increases when combined with collagen peptides or elastin peptides. Therefore, the higher the iron content, the more significant this is. The lower limit of the iron content is preferably 0.0002 w / v%, more preferably 0.001 w / v%. 0.002 w / v% is more preferable, 0.006 w / v% is even more preferable, and 0. The lower limit of the iron compound is preferably 0.001 w / v%. Preferably, 0.005 w / v% is more preferable, and 0.01 w / v% is even more preferable. 2 w / v% is more preferable, 0.03 w / v% is even more preferable, and 0.05 w / v% is It is most preferable to combine the collagen peptide of the present invention with lemon balm extract. In the oral liquid composition of the present invention, the lower limit in terms of iron is preferably 0.006 w / v%, more preferably The lower limit of the iron compound is preferably 0.03 w / v%. The upper limit of the oral administration amount of the present invention is 0.05 w / v%, more preferably 0.05 w / v%. The upper limit of iron content in the body composition is preferably 0.2 w / v%, and more preferably 0.04 w / v%. The upper limit of the iron compound content is preferably 3.3 w / v%, more preferably 1.2 w / v%. More preferable.

[0013] In the present invention, the "collagen peptide" is not particularly limited in origin and is not limited to synthetic. It may be extracted from skin, bones, ligaments, tendons, cartilage, etc., which are by-products when processing livestock such as cows and pigs, or fish. Collagen peptides produced by extracting collagen may be used, but collagen peptides derived from pigs and fish are also suitable. Peptides are preferred. Peptides are obtained by decomposing collagen proteins using enzymes or chemical treatments. Collagen peptide is preferred. The average molecular weight of the collagen peptide is not particularly limited. However, it is preferable that it is 500 to 50,000, and it is 1,000 to 25,000. The content of collagen peptide in the oral liquid composition of the present invention is more preferably 0.02 It is preferably up to 20 w / v %, more preferably 0.1 to 15 w / v %.

[0014] The collagen peptide of the present invention may be a commercially available product, for example, " Nippipeptide PS-1, Nippipeptide PRA-P, Nippipeptide F CP-EX", Zerice Co., Ltd.'s "HACP-CF", "HACP-TF", Nitta Zerice "Korapepu PU", "Korapepu JB", "HDL-50SP", "SCP" manufactured by Chin Co., Ltd. -3100" manufactured by Rousselot Co., Ltd. and "peptan P2000HD" manufactured by Rousselot Co., Ltd. The content of the "collagen peptide" of the present invention is 1 to 7500 parts by mass of iron equivalent. 0 parts by mass is preferable, 5 to 7500 parts by mass is more preferable, and 20 to 2500 parts by mass is even more preferable. Preferred.

[0015] In the present invention, the "elastin peptide" is not particularly limited in origin and is not limited to synthetic. It may be produced by hydrolyzing the aorta of an animal or the bulbus arteriosus of a fish using enzymes. However, elastin peptides derived from porcine aorta and bonito bulbus arteriosus are preferred. The elastin peptide of the present invention may be a commercially available product, for example, " P-elastin, "Bonito elastin" by Hayashikane Sangyo Co., Ltd., and "Bidan" by Nippon Suisan Co., Ltd. The molecular weight of the elastin peptide is not particularly limited, but It is preferably 0 to 20,000, and more preferably 150 to 10,000.

[0016] The content of elastin peptide in the oral liquid composition of the present invention is 0.0002 to 2 w / v %, and more preferably 0.002 to 1 w / v %.

[0017] The content of the "elastin peptide" of the present invention is 0.1 to 5 parts by mass of iron equivalent. 000 parts by mass is preferable, 0.5 to 500 parts by mass is more preferable, and 0.5 to 100 parts by mass is more preferable. is more preferable.

[0018] The lemon balm of the present invention is lemon balm (also known as Melissa) of the family Lamiaceae. It is a herbal medicine or plant derived from the leaves of Melissa officinalis (scientific name: Melissa officinalis). The herbal medicines used in the present invention are used in the form of powdered herbal medicines or plant powders, or herbal medicine extracts or plant extracts. As for the powder or plant powder, for example, a dried product in powder form obtained by further finely pulverizing a dried, chopped product is used. That's fine.

[0019] The "lemon balm extract" used in the present invention is a mixture of water, lower aliphatic alcohol (methanol, Ethanol, isopropyl alcohol, etc.), polyhydric alcohols (1,3-butylene glycol glycol, propylene glycol, dipropylene glycol, glycerin, etc.), lower aliphatic Use extractions using solvents such as ketones (e.g., acetone) or mixtures of these solvents. Of these, water, lower aliphatic alcohol, polyhydric alcohol, or a mixture of these can be used for extraction. It is most preferable to release it. The form of the extract is not particularly limited, and may be obtained by heat treatment, freeze-drying, or vacuum drying. By drying, adding excipients such as dextrin and powdering, dried extract powder and extract It can be made into powder, soft extract, liquid extract, etc. , Maruzen Pharmaceutical Co., Ltd.'s "Lemon Balm Extract A" and "Lemon Balm Extract Powder MF", Examples include "Falcorex Melissa B" by Ichimaru Falcos Co., Ltd.

[0020] The content of lemon balm extract is the net amount of lemon balm extract excluding excipients and extraction solvents. In terms of the effects of the present invention, the oral liquid composition of the present invention contains 0.0002 w / v% or more of the The upper limit is preferably 2 w / v% or more, and more preferably 0.001 w / v% or more from the viewpoint of flavor. % w / v is preferred, 0.5% w / v is more preferred, and 0.25% w / v is most preferred. When combining iron and lemon balm, the content of lemon balm extract is important for the effectiveness of the present invention. Therefore, the amount is preferably 0.001 mass part or more, and more preferably 0.005 mass part or more, per 1 mass part of iron. The upper limit is preferably 10,000 parts by mass per part by mass of iron, calculated as iron. The amount is preferably 1250 parts by mass, and more preferably 125 parts by mass.

[0021] The Houttuynia cordata of the present invention is a member of the family Houttuyniaceae, order Piperaceae. It is a crude drug or plant derived from the flowering aerial parts of Saururaceae (Saururaceae), and is available as crude drug powder or plant powder. The powdered herbal medicine or plant powder used in the present invention is For example, the dried chopped product may be further pulverized into a powdered dried product. The "Houttuynia cordata extract" used in this invention is a mixture of water, lower aliphatic alcohol (methanol, ethanol) and alcohol, isopropyl alcohol, etc.), polyhydric alcohols (1,3-butylene glycol , propylene glycol, dipropylene glycol, glycerin, etc.), lower aliphatic ketones Extracts using solvents such as acetone or a mixture of the above solvents can be used. However, it is preferable to extract with water, lower aliphatic alcohol, polyhydric alcohol, or a mixture of these. It is most preferable to

[0022] The form of the extract is not particularly limited, and may be obtained by heat treatment, freeze-drying, or vacuum drying. By drying, adding excipients such as dextrin and powdering, dried extract powder and extract It can be made into powder, soft extract, liquid extract, etc. Zen Pharmaceutical Co., Ltd.'s "Houttuynia Cordata Extract," "Houttuynia Cordata Extract BG," and "Houttuynia Cordata Extract" Uda MF" and Ichimaru Falcos' "Falcorex Houttuynia Cordata B" and "Falco Examples include "Rex Houttuynia cordata E," "Falcorex Houttuynia cordata W," and "Houttuynia cordata DXP100." It can be obtained.

[0023] The content of Houttuynia cordata extract is the net amount of Houttuynia cordata extract excluding excipients and extraction solvents. In terms of the effects of the present invention, the oral liquid composition of the present invention preferably contains 0.0002 w / v % or more. The upper limit is preferably 2 w / v% from the viewpoint of flavor. The content of Houttuynia cordata extract is preferably 0.2 w / v %, and more preferably 0.2 w / v %. Therefore, in terms of iron, the amount is preferably 0.001 parts by mass or more per 1 part by mass of iron, and more preferably 0.01 parts by mass or more. The upper limit is calculated as 1 mass part of iron. 10,000 parts by mass is preferable, 1,000 parts by mass is more preferable, and 100 parts by mass is more preferable. is more preferable.

[0024] The artichoke of the present invention is a Cyna artichoke of the family Asteraceae, order Asterales. It is a crude drug or plant derived from the leaves of ra scolymus Linne (Compositae), and is available as crude drug powder or plant powder. The powdered herbal medicine or plant powder used in the present invention is For example, the dried chopped product may be further pulverized into a powdered dried product. The "artichoke extract" used in the present invention is a mixture of water, a lower aliphatic alcohol (methanol), and alcohol, ethanol, isopropyl alcohol, etc.), polyhydric alcohols (1,3-butylene glycol, (glycol, propylene glycol, dipropylene glycol, glycerin, etc.), low-molecular-weight fats Use extractions using solvents such as aliphatic ketones (e.g., acetone) or mixtures of these solvents. Among these, water, lower aliphatic alcohol, polyhydric alcohol or a mixture thereof is preferred. It is most preferred to extract it with The form of the extract is not particularly limited, and may be obtained by heat treatment, freeze-drying, or vacuum drying. By drying, adding excipients such as dextrin and powdering, dried extract powder and extract It can be made into powder, soft extract, liquid extract, etc. The following is a list of products that are being developed by Ichimaru Pharcos Co., Ltd.: "Biobenefity (registered trademark)" and "Biobenef Biobenefity G, Biobenefity HS, Cynaropicrin F, Biobenefity F" and others.

[0025] The content of artichoke extract is the net amount of artichoke excluding excipients and extraction solvents. In terms of the effects of the present invention, the oral liquid composition of the present invention contains 0.0002 w / The upper limit is set from the viewpoint of flavor. 2 w / v% is preferable, and 0.06 w / v% is more preferable. In terms of the effects of the present invention, the content of is 0.001 parts by mass or more per 1 part by mass of iron in terms of iron. parts by mass or more is preferable, 0.003 parts by mass or more is more preferable, and 0.015 parts by mass or more is even more preferable. The upper limit is preferably 10,000 parts by mass in terms of iron per part by mass of iron, and 300 parts by mass. 10 parts by mass is more preferable, and 30 parts by mass is even more preferable.

[0026] The rosemary of the present invention is a plant of the Lamiaceae family (scientific name: Rosmarinus Officinalis ) is a crude drug or plant derived from the leaves, and is a crude drug powder or plant powder, crude drug extract or plant extract The powdered herbal medicine or plant powder used in the present invention may be, for example, a dried, chopped, processed product. It may also be finely ground into a dried powder. is water, lower aliphatic alcohol (methanol, ethanol, isopropyl alcohol, etc.) ), polyhydric alcohol (1,3-butylene glycol, propylene glycol, dipropylene glycol solvents such as ethylene glycol, glycerin, lower aliphatic ketones (acetone, etc.) and Extracts using a mixture of solvents can be used, among which water, lower aliphatic alcohols, Most preferably, the extraction is carried out with coal, a polyhydric alcohol, or a mixture thereof. The form of the extract is not particularly limited, and may be obtained by heat treatment, freeze-drying, or vacuum drying. By drying, adding excipients such as dextrin and powdering, dried extract powder and extract It can be made into powder, soft extract, liquid extract, etc. The extract used in the present invention is also a commercially available product. Marie Extract (Bioactives Japan) and Rosemary Extract MF (Maruzen Pharmaceuticals) " etc.

[0027] The content of rosemary extract is the net rosemary extract excluding excipients and extraction solvents. In terms of the effects of the present invention, the oral liquid composition of the present invention contains 0.0002 w / v% or more of the The upper limit is preferably 2.0 w / v%, and more preferably 0.0008 w / v% or more. The content of rosemary extract is preferably 0.1 w / v%, more preferably 0.1 w / v%. From the viewpoint of the effect of the present invention, the amount is preferably 0.001 parts by mass or more per 1 part by mass of iron, calculated as iron. The upper limit is more preferably 0.004 parts by mass or more, and even more preferably 0.02 parts by mass or more. is preferably 10,000 parts by mass, more preferably 500 parts by mass, per part by mass of iron, calculated as iron. 50 parts by mass is more preferable.

[0028] The present invention provides a method for preventing discomfort caused by combining an iron compound with a collagen peptide or an elastin peptide. The odor is reduced by using specific plant extracts, namely lemon balm extract, Houttuynia cordata extract, and artichoke extract. This can be significantly suppressed by adding ginger extract or rosemary extract.

[0029] The oral liquid composition of the present invention is not particularly limited as long as it is a liquid that can be taken orally. Medicines, quasi-drugs, or food (not only general foods, but also nutritional functional foods and foods for specified health uses) (including functional foods)

[0030] Examples of pharmaceuticals and quasi-drugs include oral liquids and energy drinks. Foods include soft drinks, carbonated drinks, sports and functional drinks, non-alcoholic drinks, Examples include milk drinks, tea drinks, coffee drinks, fruit and vegetable drinks, and jelly drinks. Preferably, for pharmaceuticals and quasi-drugs, oral liquids, energy drinks, and for foods, nutritional supplements. These include various beverages such as functional foods and foods for specified health uses, carbonated drinks, and jelly drinks.

[0031] The pH of the oral liquid composition of the present invention is not particularly limited, but from the viewpoint of palatability, The pH is preferably 2.5 to 4.5, and more preferably 3.0 to 4.0. If necessary, a pH adjuster such as an organic acid may be added.

[0032] The oral liquid composition of the present invention can be produced by a conventional method, and the method is not particularly limited. Usually, each ingredient is weighed out, dissolved in an appropriate amount of purified water, stirred, and then the pH is adjusted. The volume is adjusted by adding purified water, and filtering and sterilizing the solution as necessary. Obtained.

[0033] The oral liquid composition of the present invention may further contain other ingredients such as vitamins, minerals, Amino acids and their salts, herbal medicines, herbal extracts, caffeine, royal jelly, dextrin etc. can be appropriately blended within a range that does not impair the effects of the present invention. Additives such as antioxidants, colorants, flavorings, flavoring agents, preservatives, sweeteners, and acidulants may be used in order to achieve the effects of the present invention. It can be appropriately blended within a range that does not impair the properties. [Example]

[0034] The present invention will be described in more detail below with reference to examples and comparative examples.

[0035] (Comparative Examples 1-1 to 18, Examples 1-1 to 18) Oral liquid compositions were prepared according to the formulations shown in Tables 1 to 10 below and the following method. Approximately 60% of the total volume is purified water, and collagen peptide (pork-derived: manufactured by Nitta Gelatin Co., Ltd.) Lapep JB, manufactured by Nippi Co., Ltd. Nippi Peptide PRA-P, fish-derived: manufactured by Nippi Co., Ltd. Nippipeptide FCP-EX), or elastin peptide (fish-derived: Hayashikane Sangyo Co., Ltd. Bonito elastin, pork-derived: P-elastin manufactured by Nippon Meat Packers Co., Ltd.), citric acid, benzoin Sodium citrate was added and stirred thoroughly. Then, ammonium iron citrate was added. Purified water was added to make up about 80% of the total volume, and the mixture was thoroughly stirred. Lemon balm extract (hot water extract, lemon balm extract powder manufactured by Maruzen Pharmaceutical Co., Ltd.) MF), Houttuynia cordata extract (water extract, Houttuynia cordata extract powder manufactured by Nippon Powder Pharmaceutical Co., Ltd. Artichoke extract (ethanol extract, manufactured by Ichimaru Pharcos Co., Ltd.) Obenefity F), or rosemary extract (hot water extract, Maruzen Pharmaceutical Co., Ltd.) Add rosemary extract MF) and stir thoroughly, then use hydrochloric acid or sodium hydroxide The pH was adjusted using the above and purified water was added to make up the total volume, to obtain oral liquid compositions (Examples 1-1 to 18). These oral liquid compositions were filled in screw tubes No. 7 (manufactured by Maruemu Co., Ltd.) at 50 ml each. The oral liquid composition containing no plant extract was used as a control. The results were used as a control (Comparative Examples 1 to 18). The oral liquid compositions prepared as described above were stored at 65°C for 7 days, and then smelled. The degree of reduction in unpleasant odor was evaluated based on the standard. The amount of each extract in Tables 1 to 10 does not include the excipients and extraction solvents contained in the raw extract. This is the net extract amount.

[0036] [Table 1]

[0037] [Table 2]

[0038] [Table 3]

[0039] [Table 4]

[0040] [Table 5]

[0041] [Table 6]

[0042] [Table 7]

[0043] [Table 8]

[0044] [Table 9]

[0045] [Table 10]

[0046] [Table 11]

[0047] As shown in Tables 1 to 6, by combining iron compounds and collagen peptides, A pleasant odor was produced (Comparative Examples 1 to 10). As the concentration of collagen peptide increased, the proportion of unpleasant odors also decreased. The rate of unpleasant odor also increased with increasing iron concentration (Comparative Examples 1 to 3). 2, 4, 5, 7). On the other hand, lemon balm extract, Houttuynia cordata extract, artichoke extract By blending the extract of rosemary or malt extract, the rate of unpleasant odor was reduced (Example 1-1 to Example 10-3). As shown in Tables 7 to 10, when iron compounds and elastin peptides were combined, However, an unpleasant odor was generated (Comparative Examples 11 to 18). The proportion of unpleasant odors also increased (Comparative Examples 12, 14, and 15). On the other hand, the effects of lemon balm extract, Houttuynia cordata extract, and Artemisia annua extract also increased (Comparative Examples 12 and 13). By blending chalk extract or rosemary extract, the rate of unpleasant odors is reduced. The results were as follows (Examples 11-1 to 18). [Industrial Applicability]

[0048] According to the present invention, an iron compound and collagen peptide or ella in an oral liquid composition It has become possible to suppress the unpleasant odor when sterol peptides are blended, so it is In the fields of quasi-drugs and food, highly marketable iron compounds and collagen peptides or ella It is expected to provide an oral liquid composition containing a steroid peptide.

Claims

1. (A) an iron compound, (B) elastin peptides, (C) An oral liquid composition characterized by containing at least one plant extract selected from the group consisting of artichoke extract and rosemary extract.

2. 2. The oral liquid composition according to claim 1, wherein the content of the iron compound (A) is 0.0002 to 0.2 w / v % in terms of iron.

3. The oral liquid composition according to claim 1 or 2, wherein the content of (B) elastin peptide is 0.0002 to 2 w / v%.

4. 4. The oral liquid composition according to claim 1, wherein the content of (C) at least one plant extract selected from the group consisting of artichoke extract and rosemary extract is 0.0002 to 2 w / v %.

5. 5. The oral liquid composition according to claim 1, wherein the iron compound is at least one selected from the group consisting of ferrous fumarate, ferric chloride, iron citrate, ammonium ferrous citrate, sodium ferrous citrate, ferrous gluconate, iron lactate, ferrous pyrophosphate, ferric pyrophosphate, ferrous sulfate, and heme iron.

6. The oral liquid composition according to any one of claims 1 to 5, having a pH of 2.5 to 4.

5.

7. 7. The oral liquid composition according to claim 1, which is a liquid beverage.

8. A method for suppressing an unpleasant odor caused by blending an iron compound with an elastin peptide by blending at least one plant extract selected from the group consisting of artichoke extract and rosemary extract.

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