Methods for identifying compounds binding to a target molecule using mirror-imaging of the target molecule
WO2025042899A3 Publication Date: 2025-04-17X CHEM
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Patent Information
- Application Number
- PCT/US2024/043052
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-08-24
- Filing Date
- 2024-08-20
- Publication Date
- 2025-04-17
AI Technical Summary
Technical Problem
Current methods for screening DNA-encoded combinatorial libraries are limited in efficiency, particularly when targeting nucleic acid or nucleic acid-binding protein molecules that can bind to DNA.
Method used
The method involves providing a set of candidate compounds with DNA tags, contacting them with a mirror-image of the target molecule, and selecting compounds that bind to the mirror-image, thereby identifying compounds that bind to the original target molecule.
Benefits of technology
This approach enhances the efficiency of identifying compounds that bind to target molecules by minimizing DNA-mediated binding and allowing for the identification of both the binding compound and its mirror-image as effective binders.
✦ Generated by Eureka AI based on patent content.
Abstract
The present disclosure provides methods of screening DNA-encoded chemical libraries utilizing mirror-images of target molecules. These methods allow highly efficient selection of compounds that bind to a target molecule, even when the target molecule can bind the DNA tag of the encoded compounds.
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