18f-fluorodeoxysorbitol positron emission tomography for noninvasive detection of invasive mold infections in patients

18F-FDS PET-CT imaging offers a non-invasive and sensitive method for diagnosing invasive mold infections, addressing the limitations of current invasive and time-consuming diagnostic methods by accurately detecting and monitoring mold infections.

WO2026072892A1 Publication Date: 2026-04-02JOHNS HOPKINS UNIVERSITY
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Patent Information

Application Number
PCT/US2025/048091
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2025-02-27
Filing Date
2025-09-26
Publication Date
2026-04-02

AI Technical Summary

Technical Problem

Current methods for diagnosing invasive mold infections are invasive, time-consuming, and lack sensitivity and specificity, particularly for non-Aspergillus molds, leading to delayed treatment and high mortality rates.

Method used

Administering 18F-fluorodeoxy sorbitol (18F-FDS) to a subject and using PET-CT imaging to detect mold infections by monitoring the uptake of 18F-FDS, allowing for non-invasive, sensitive detection of various mold species, including Aspergillus and non-Aspergillus molds.

Benefits of technology

Provides rapid, accurate, and non-invasive detection of mold infections, enabling early treatment initiation and differentiation from other conditions like sterile inflammation and cancer, with the ability to monitor treatment response.

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Abstract

Methods for detecting a mold infection in a subject, comprising administering 18F-fluorodeoxysorbitol (18F-FDS) to the subject and taking an image, e.g., a positron emission tomography (PET) and computed tomography (CT) image, are disclosed. The mold infection can include, for example, an Aspergillus, a non-Aspergillus (galactomannan-negative), or an azole-resistant (Aspergillus calidoustus) mold infection, or other clinically relevant molds.
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