Chitosan cervix uteri anti-microbial membrane and preparation method thereof

Abstract

The invention discloses a chitosan cervix uteri anti-microbial membrane and a preparation method thereof. The chitosan cervix uteri anti-microbial membrane has a structure of a circular plate, bulged flangings are formed at the periphery of the circular plate, and a convex body is arranged in the center of the reverse side of the circular plate. The chitosan cervix uteri anti-microbial membrane is prepared from the following raw materials in percentage by mass: 0.5 to 5.0 percent of chitosan iodine, 2.0 to 10.0 percent of polysorbate-20, 0.1 to 2.0 percent of acetic acid, 0.1 to 5.0 percent of hydroxypropyl methyl cellulose, 1.0 to 10.0 percent of gelatin, 1.0 to 10.0 percent of glycerol and the balance of purified water. The chitosan cervix uteri anti-microbial membrane is prepared from novel biological materials synthesized by the chitosan and derivatives thereof by processes of freezing, vacuum drying and the like according to characteristics of human anatomy, pathology, physiology and the like, has a shape of a thin curved surface, and can be in full fit with pathological tissue, absorb wound exudate and eliminate necrotic tissue by being attached to cervix uteri surfaces outside uterine cavities, so that wounds are drained fully; and sterilizing inflammation-diminishing active factors are released in a sustained way at the targeting position to promote wound union effectively. The chitosan cervix uteri anti-microbial membrane is suitable for patients who suffer from gynecological cervical diseases.

Description

technical field

[0001] The invention relates to a pharmaceutical preparation containing organic active ingredients, specifically, to a chitin-containing medicinal preparation, and to a preparation method thereof. Background technique

[0002] 40% of women of childbearing age suffer from cervicitis. The treatment of cervicitis is mainly local treatment, among which physical therapy is the first choice. The curative effect of drug treatment is not good, and it is often an auxiliary means. Existing physical therapy methods include Leep knife, freezing, dark light infrared coagulation therapy, microwave therapy, etc. Most of the curative effects of physical therapy are quite satisfactory, but because a wound is formed while removing the festering tissue of the cervix, it usually takes about 2 months to heal completely, due to the special physiological structure of the cervix and the particularity of the cervicitis wound above At present, there is no satisfactory medicine or mat...

Examples

Embodiment

[0023] Get chitosan iodine 20g, polysorbate-20 60g, acetic acid 10g, hydroxypropyl methylcellulose 10g, gelatin 50g, glycerin 50g, and purified water 800mL, altogether 1000g material;

[0024] Add gelatin into a stirring container filled with purified water, set the temperature of the water bath at 60°C to heat, keep stirring for about 4 hours to dissolve; then add hydroxypropyl methylcellulose and continue stirring for about 2 hours to dissolve; then add the prescribed amount Stir the glycerin to mix evenly; after that, stir to cool the material to about 30°C, and mix it with the prepared chitosan-iodine solution evenly to inject the film; finally, after the film is injected, put the mold into a freeze dryer and freeze at -50°C After freezing for 4 hours, remove the cover, continue to freeze for 2 hours, and enter into freeze-vacuum drying; after freeze-vacuum drying, take it out from the machine in a sterile state, put it into boxes, add outer packaging, and sterilize to obta...

technical field

[0001] The invention relates to a pharmaceutical preparation containing organic active ingredients, specifically, to a chitin-containing medicinal preparation, and to a preparation method thereof. Background technique

[0002] 40% of women of childbearing age suffer from cervicitis. The treatment of cervicitis is mainly local treatment, among which physical therapy is the first choice. The curative effect of drug treatment is not good, and it is often an auxiliary means. Existing physical therapy methods include Leep knife, freezing, dark light infrared coagulation therapy, microwave therapy, etc. Most of the curative effects of physical therapy are quite satisfactory, but because a wound is formed while removing the festering tissue of the cervix, it usually takes about 2 months to heal completely, due to the special physiological structure of the cervix and the particularity of the cervicitis wound above At present, there is no satisfactory medicine or mat...

Examples

Embodiment

[0023] Get chitosan iodine 20g, polysorbate-20 60g, acetic acid 10g, hydroxypropyl methylcellulose 10g, gelatin 50g, glycerin 50g, and purified water 800mL, altogether 1000g material;

[0024] Add gelatin into a stirring container filled with purified water, set the temperature of the water bath at 60°C to heat, keep stirring for about 4 hours to dissolve; then add hydroxypropyl methylcellulose and continue stirring for about 2 hours to dissolve; then add the prescribed amount Stir the glycerin to mix evenly; after that, stir to cool the material to about 30°C, and mix it with the prepared chitosan-iodine solution evenly to inject the film; finally, after the film is injected, put the mold into a freeze dryer and freeze at -50°C After freezing for 4 hours, remove the cover, continue to freeze for 2 hours, and enter into freeze-vacuum drying; after freeze-vacuum drying, take it out from the machine in a sterile state, put it into boxes, add outer packaging, and sterilize to obta...

Images