Preparation method of 4-(hydroxymethyl) benzo 15-crown-5
Through a two-step synthesis method for preparing 4'-formylbenzo15-crown-5 and 4-(hydroxymethyl)benzo15-crown-5, the problems of compound preparation and purification are solved, and efficient synthesis and high yield are achieved rate of 4-(hydroxymethyl)benzo-15-crown-5, supporting its use in therapeutics and research.
Patent Information
- Application Number
- CN201210433173.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2012-11-02
- Publication Date
- 2013-01-16
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
In the process of developing compounds with new functions, it is difficult to effectively prepare and purify 4-(hydroxymethyl)benzo-15-crown-5 with existing technology, which limits its application in treatment and research.
A two-step synthesis method for the preparation of 4'-formylbenzo15-crown-5 and 4-(hydroxymethyl)benzo15-crown-5, utilizing tetraethylene glycol diphenylsulfonate and 3,4- Reaction of dihydroxybenzaldehyde in DMF, followed by treatment with potassium hydroxide and water, followed by reaction with sodium borohydride in MeOH, and purification by column chromatography, controlling reaction conditions and ratios to achieve high yield purification.
The efficient synthesis and purification of 4-(hydroxymethyl)benzo-15-crown-5 was achieved, with a yield of more than 80%. It provided scientific and reasonable production methods and product identification support, laying the foundation for subsequent research and development.