A preparation method for solid film dip-coated with a novel chiral recognition agent

Abstract

A preparation method for solid film dip-coated with a novel chiral recognition agent belongs to the technical field of film separation. The method comprises: synthesis of a cyclodextrin-type chiral ionic liquid; preparation of a crosslinking solution; treatment of base film; soaking of film sheets in a chiral ionic liquid / chitosan crosslinking solution or a polyanionic film-making solution and a chiral ionic liquid film-making solution; washing of composite film sheets; and drying of film sheets. The method for preparing chiral solid film is easy, few in steps and low in requirements on equipment. Chiral separation experiments show that the use of the chiral separation solid film prepared by the method can realize high selectivity and low energy consumption in chiral separation processes.

Description

technical field

[0001] The invention relates to a method for preparing a solid film dip-coated with a novel chiral recognition agent, which belongs to the technical field of membrane separation, and in particular is used in the field of solid film separation of chiral compounds. Background technique

[0002] The separation technology of chiral substances is one of the key technologies in the fields of modern biology and functional materials. During its long-term development, it has been found that the membrane separation method has the advantages of low energy consumption and easy continuous operation, and is one of the ideal methods for large-scale chiral separation. Chiral liquid membranes tend to suffer from poor stability in long-term use, which greatly limits its development. Solid film separation can effectively overcome this shortcoming, and has the advantages of simple operation, economy, mild conditions, and easy continuous operation, and has become a method with g...

Examples

specific Embodiment 1

[0035] In this implementation, the nylon 6 membrane with electronegativity itself is used as the base membrane, the pore size is 0.22 μm, and the chiral ionic liquid used is mono-6-deoxy-6-(3-methylimidazole) β-cyclodextrin p-toluene Sulfonate, chitosan is industrial grade, polyanion is polyphenylacrylic acid (PAA, molecular weight 4×10 6 ).

[0036] Specific operation and method:

[0037](1) To prepare cyclodextrin-based chiral ionic liquids, the specific steps are: ①Add 625ml deionized water to a 1000ml beaker, weigh 75g of β-cyclodextrin, slowly add it to the above deionized water, and keep stirring , the temperature is controlled at about 10°C-20°C, and the liquid in the beaker becomes a turbid white suspension; ② Weigh 8.2125g NaOH and dissolve it in 25ml water, and after it is completely dissolved, slowly add it dropwise to the above-mentioned In the suspension, the suspension becomes clear after the dropwise addition, and the clear solution continues to be stirred for...

specific Embodiment 2

[0046] In this implementation, a polyacrylonitrile membrane (PAN membrane) is used as the base membrane, and the chiral ionic liquid used is mono-6-deoxy-6-(3-methylimidazole) β-cyclodextrin p-toluenesulfonate, chitosan The sugar is industrial grade, and the polyanion is polyphenylacrylic acid (PAA, molecular weight 4×10 6 ).

[0047] Specific operation and method:

[0048] (1) Prepare cyclodextrin-based chiral ionic liquids. The specific steps are: ① Add 625ml of pure water to a 1000ml beaker, weigh 75g of β-cyclodextrin, slowly add it to the above deionized water, and keep stirring , the temperature is controlled at about 10°C-20°C, and the liquid in the beaker becomes a turbid white suspension; ② Weigh 8.2125g NaOH and dissolve it in 25ml water, and after it is completely dissolved, slowly add it dropwise to the above-mentioned In the suspension, the suspension becomes clear after the dropwise addition, and the clear solution continues to be stirred for 60 minutes; ③Weigh...

technical field

[0001] The invention relates to a method for preparing a solid film dip-coated with a novel chiral recognition agent, which belongs to the technical field of membrane separation, and in particular is used in the field of solid film separation of chiral compounds. Background technique

[0002] The separation technology of chiral substances is one of the key technologies in the fields of modern biology and functional materials. During its long-term development, it has been found that the membrane separation method has the advantages of low energy consumption and easy continuous operation, and is one of the ideal methods for large-scale chiral separation. Chiral liquid membranes tend to suffer from poor stability in long-term use, which greatly limits its development. Solid film separation can effectively overcome this shortcoming, and has the advantages of simple operation, economy, mild conditions, and easy continuous operation, and has become a method with g...

Examples

specific Embodiment 1

[0035] In this implementation, the nylon 6 membrane with electronegativity itself is used as the base membrane, the pore size is 0.22 μm, and the chiral ionic liquid used is mono-6-deoxy-6-(3-methylimidazole) β-cyclodextrin p-toluene Sulfonate, chitosan is industrial grade, polyanion is polyphenylacrylic acid (PAA, molecular weight 4×10 6 ).

[0036] Specific operation and method:

[0037](1) To prepare cyclodextrin-based chiral ionic liquids, the specific steps are: ①Add 625ml deionized water to a 1000ml beaker, weigh 75g of β-cyclodextrin, slowly add it to the above deionized water, and keep stirring , the temperature is controlled at about 10°C-20°C, and the liquid in the beaker becomes a turbid white suspension; ② Weigh 8.2125g NaOH and dissolve it in 25ml water, and after it is completely dissolved, slowly add it dropwise to the above-mentioned In the suspension, the suspension becomes clear after the dropwise addition, and the clear solution continues to be stirred for...

specific Embodiment 2

[0046] In this implementation, a polyacrylonitrile membrane (PAN membrane) is used as the base membrane, and the chiral ionic liquid used is mono-6-deoxy-6-(3-methylimidazole) β-cyclodextrin p-toluenesulfonate, chitosan The sugar is industrial grade, and the polyanion is polyphenylacrylic acid (PAA, molecular weight 4×10 6 ).

[0047] Specific operation and method:

[0048] (1) Prepare cyclodextrin-based chiral ionic liquids. The specific steps are: ① Add 625ml of pure water to a 1000ml beaker, weigh 75g of β-cyclodextrin, slowly add it to the above deionized water, and keep stirring , the temperature is controlled at about 10°C-20°C, and the liquid in the beaker becomes a turbid white suspension; ② Weigh 8.2125g NaOH and dissolve it in 25ml water, and after it is completely dissolved, slowly add it dropwise to the above-mentioned In the suspension, the suspension becomes clear after the dropwise addition, and the clear solution continues to be stirred for 60 minutes; ③Weigh...