Novel synthetic method for 5-phenyl tetrazole
In the production of 5-phenyltetrazole, the azide reaction is carried out under acidic and alkaline conditions after neutralization of hydrazine hydrate and acid, which solves the problem of sodium azide being explosive and realizes the safety of the process. and high yield improvement.
CN103351352AInactive Publication Date: 2013-10-16姜树林
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- 姜树林
- Filing Date
- 2013-07-15
- Publication Date
- 2013-10-16
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Technical Problem
The sodium azide used in the existing 5-phenyltetrazole production process is explosive, the process is unsafe, and the yield is low.
Method used
Neutralize with hydrazine hydrate and acid, then add a mixed solution of benzonitrile, water and ethanol to generate phenylaminoguanidine salt, which is diazotized with sodium nitrite under acidic conditions, followed by ring-closing reaction under alkaline conditions, and passed through ethanol. Purify to obtain crude 5-phenyltetrazole.
Benefits of technology
The simplicity, safety and high yield of the process are achieved, and the quality of the product is improved.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses a novel synthetic method for 5-phenyl tetrazole, which includes the following steps: firstly performing acid neutralization to hydrazine hydrate; then adding mixing solution formed by cyanobenzene, water and ethyl alcohol to generate phenyl aminoguanidine salt; adopting sodium nitrite for diazotization to obtain nitrine amidine under the acidic condition; obtaining 5-phenyl tetrazole crude product through closed loop under the alkaline condition; obtaining 5-phenyl tetrazole acceptable product through adopting ethyl alcohol for refining. The method has the advantages of simple technology, simplicity in operation and high product yield.
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