Pharmaceutical preparation for treating chronic bronchitis and preparation method thereof

Abstract

The invention discloses a pharmaceutical preparation for treating chronic bronchitis, which is prepared from boenninghausenia albiflora extractive and rhynchelytrum repens extractive according to a weight ratio of (2-4):1. The invention finds for the first time that the combined use of the boenninghausenia albiflora extractive and the rhynchelytrum repens extractive can achieve a very good treatment effect for chronic bronchitis and have obviously actions of resisting inflammation, eliminating phlegm by cooling, and relieving cough and detoxifying. In vitro test shows that the combined use ofboenninghausenia albiflora extractive and rhynchelytrum repens extractive has a remarkable antibacterial activity for multiple pathogenic bacteria causing chronic bronchitis; animal test shows that the combined use of boenninghausenia albiflora extractive and rhynchelytrum repens extractive can obviously increase the amount of expectoration of capillary of a rat, and thus has a good phlegm eliminating effect; and the combined use has an obvious inhibiting effect for cough induced by a spaying method with stronger ammonia water for a mouse. Clinical test shows that the pharmaceutical preparation has a remarkable treatment effect for chronic bronchitis, is reliable in effect and gentle in drug property, and does not have toxic or side effect.

Description

Technical field

[0001] The invention relates to a pharmaceutical preparation for treating chronic bronchitis and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. Background technique

[0002] Chronic bronchitis (CB) is a common chronic non-specific respiratory disease. The main clinical features are recurrent cough, sputum or wheezing. Its morbidity is high, the condition is repeated, it can be complicated by obstructive emphysema, even pulmonary hypertension, pulmonary heart disease, etc. Clinically, chronic bronchitis with airway obstruction, emphysema, and other obstructive lesions of the small airways are collectively referred to as chronic obstructive pulmonary disease; the harm is serious, and the current research on the prevention and treatment of chronic bronchitis has been studied by domestic and foreign scholars. General attention.

[0003] For the treatment of chronic bronchitis, at present, western medicines are commonly...

Examples

Embodiment 1

[0030] (1) Preparation of Rock Pepper Extract

[0031] Add 10 times the weight of water to rock pepper grass and decoct 3 times, 2 hours each time, combine the decoction, concentrate the decoction to a relative density of 1.10-1.20 (measured at 50℃), add 95% ethanol (volume fraction) ) Until the alcohol content of the solution is 70% (volume fraction), refrigerate overnight, filter, and concentrate and dry the filtrate to obtain the Rock Pepper extract.

[0032] (2) Preparation of Red Hair Extract

[0033] Take 100 grams of dried red hair grass, crush it, add 1000ml of ethanol solution with a volume concentration of 95%, reflux for 3h at 90℃, filter, and keep the filtrate and residue for use; the filtrate is concentrated to a relative density of 1.2 (measured at 50℃) ) To obtain a concentrated solution, which is spray-dried at 150° C. to obtain an alcohol-soluble extract of salamandra.

[0034] Take the filtered residue, add 1200ml of distilled water, decoct for 3h, filter, concentra...

Embodiment 2

[0039] The preparation methods of rock pepper extract and red hair grass extract are the same as in Example 1.

[0040] The rock pepper grass extract and the red hair grass extract are mixed at a weight ratio of 1:1 to obtain a pharmaceutical composition for treating chronic bronchitis.

Embodiment 3

[0042] The preparation methods of rock pepper extract and red hair grass extract are the same as in Example 1.

[0043] The rock pepper grass extract and the red hair grass extract are mixed at a weight ratio of 3:1 to obtain a pharmaceutical composition for treating chronic bronchitis.

Technical field

[0001] The invention relates to a pharmaceutical preparation for treating chronic bronchitis and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. Background technique

[0002] Chronic bronchitis (CB) is a common chronic non-specific respiratory disease. The main clinical features are recurrent cough, sputum or wheezing. Its morbidity is high, the condition is repeated, it can be complicated by obstructive emphysema, even pulmonary hypertension, pulmonary heart disease, etc. Clinically, chronic bronchitis with airway obstruction, emphysema, and other obstructive lesions of the small airways are collectively referred to as chronic obstructive pulmonary disease; the harm is serious, and the current research on the prevention and treatment of chronic bronchitis has been studied by domestic and foreign scholars. General attention.

[0003] For the treatment of chronic bronchitis, at present, western medicines are commonly...

Examples

Embodiment 1

[0030] (1) Preparation of Rock Pepper Extract

[0031] Add 10 times the weight of water to rock pepper grass and decoct 3 times, 2 hours each time, combine the decoction, concentrate the decoction to a relative density of 1.10-1.20 (measured at 50℃), add 95% ethanol (volume fraction) ) Until the alcohol content of the solution is 70% (volume fraction), refrigerate overnight, filter, and concentrate and dry the filtrate to obtain the Rock Pepper extract.

[0032] (2) Preparation of Red Hair Extract

[0033] Take 100 grams of dried red hair grass, crush it, add 1000ml of ethanol solution with a volume concentration of 95%, reflux for 3h at 90℃, filter, and keep the filtrate and residue for use; the filtrate is concentrated to a relative density of 1.2 (measured at 50℃) ) To obtain a concentrated solution, which is spray-dried at 150° C. to obtain an alcohol-soluble extract of salamandra.

[0034] Take the filtered residue, add 1200ml of distilled water, decoct for 3h, filter, concentra...

Embodiment 2

[0039] The preparation methods of rock pepper extract and red hair grass extract are the same as in Example 1.

[0040] The rock pepper grass extract and the red hair grass extract are mixed at a weight ratio of 1:1 to obtain a pharmaceutical composition for treating chronic bronchitis.

Embodiment 3

[0042] The preparation methods of rock pepper extract and red hair grass extract are the same as in Example 1.

[0043] The rock pepper grass extract and the red hair grass extract are mixed at a weight ratio of 3:1 to obtain a pharmaceutical composition for treating chronic bronchitis.

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