Osteocarcinoma pain-killing composite and plaster and preparation method and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an osteocarcinoma pain-killing composite and plaster and a preparation method and applicationthereof. The osteocarcinoma pain-killing composite is prepared from the following ingredients in parts by weight: 1.8-2.2 parts of venenum bufonis, 14.0-18.0 parts of methyl salicylate, 8.0-12.0 parts of radix angelicae, 8.0-12.0 parts of mirabilite, 1.8-2.2 parts of myrrh, 1.8-2.2 parts of herba asari, 4.0-6.0 parts of peony seed oil and the like. The invention also provides an osteocarcinoma pain-killing plaster which contains the above osteocarcinoma pain-killing composite, and is prepared by mixing the above osteocarcinoma pain-killing composite with thickening agent. The osteocarcinoma pain-killing composite and plaster provided by the invention can perform an obvious pain killing effect in short time, and also can perform a detumescence effect, a user can feel that pain is relievedafter the osteocarcinoma pain-killing composite and plaster is applied for about 15 minutes, and in addition, the osteocarcinoma pain-killing composite and plaster does not have any irritation and toxic and side effects on whole and local skin.

Description

technical field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a bone cancer analgesic composition, plaster, preparation method and application thereof. Background technique

[0002] Cancer pain is currently the most unbearable pain and is a common worldwide problem. The World Health Organization advocates a three-level analgesic ladder, and effective analgesic treatment, especially for advanced cancer patients, is one of the four priorities in the World Health Organization's comprehensive cancer program. Cancer has the highest incidence of pain, with at least 40% of patients with the condition experiencing pain. In patients with bone cancer, the growth of malignant tumors in the bone is accompanied by the invasion and compression of peripheral nerves, the release of inflammatory and tumor factors, and the changes in cell signaling pathways. These factors together lead to persistent and explosive pain in bon...

Examples

Embodiment 1

[0058] (1) Pulverize and sieve toad venom, Angelica dahurica, Glauber's salt, Myrrh and Asarum respectively;

[0059] (2) Put 4.0 parts of peony seed oil in the mixer, add 1.8 parts of myrrh prepared in step (1) and 1.8 parts of asarum prepared in step (1), stir while adding, and stir until fully mixed Homogenize to obtain the mixed drug;

[0060] (3) in the mixed medicine that step (2) makes, add the Radix Angelica dahuricae that 1.8 parts of steps (1) make, the methyl salicylate of 14.0 parts, 8.0 parts of steps (1) make, 8.0 parts of steps ( 1) The prepared Glauber's salt, 1.8 parts of mint ice and 1.8 parts of borneol were stirred while adding, and stirred until fully mixed to obtain a bone cancer analgesic composition;

[0061] (4) Add 27.0 parts of vaseline, 20.0 parts of lanolin and 3.0 parts of glycerin aqueous solution (the volume ratio of glycerin and water is 1:3) to the bone cancer analgesic composition prepared in step (3) to adjust the viscosity , stir evenly, ...

Embodiment 2

[0064] (1) Pulverize and sieve toad venom, Angelica dahurica, Glauber's salt, Myrrh and Asarum respectively;

[0065] (2) Put 5.0 parts of peony seed oil in a blender, add 2.0 parts of myrrh prepared in step (1) and 2.0 parts of asarum prepared in step (1), stir while adding, and stir until fully mixed Homogenize to obtain the mixed drug;

[0066] (2) in the mixed medicine that step (2) makes, add the Radix Angelica dahuricae that 2.0 parts of steps (1) make, the methyl salicylate of 16.0 parts, 10.0 parts of steps (1) make, 10.0 parts of steps ( 1) The prepared Glauber's salt, 2.0 parts of mint ice and 2.0 parts of borneol are stirred while adding, and stirred until fully mixed to obtain a bone cancer analgesic composition;

[0067] (4) Add 29.0 parts of vaseline, 22.0 parts of lanolin and 4.0 parts of glycerin aqueous solution (the volume ratio of glycerin and water is 1:3) to the bone cancer analgesic composition prepared in step (3) to adjust the viscosity , stir evenly,...

Embodiment 3

[0070] (1) Pulverize and sieve toad venom, Angelica dahurica, Glauber's salt, Myrrh and Asarum respectively;

[0071] (2) Put 6.0 parts of peony seed oil in a blender, add 2.2 parts of myrrh prepared in step (1) and 2.2 parts of asarum prepared in step (1), stir while adding, and stir until fully mixed Homogenize to obtain the mixed drug;

[0072] (3) add 2.2 parts of toad venom prepared in step (1), 18.0 parts of methyl salicylate, 12.0 parts of Angelica dahurica prepared in step (1), 12.0 parts of step (1) in the mixed medicine prepared in step (2). ) prepared Glauber's salt, 2.2 parts of mint ice and 2.2 parts of borneol, stirred while adding, and stirred until fully mixed to obtain a bone cancer pain-relieving composition;

[0073] (4) Add 31.0 parts of Vaseline, 24.0 parts of lanolin and 5.0 parts of aqueous glycerin (the volume ratio of glycerin and water is 1:3) to the bone cancer analgesic composition prepared in step (3) to adjust the viscosity , stir evenly, and le...

technical field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a bone cancer analgesic composition, plaster, preparation method and application thereof. Background technique

[0002] Cancer pain is currently the most unbearable pain and is a common worldwide problem. The World Health Organization advocates a three-level analgesic ladder, and effective analgesic treatment, especially for advanced cancer patients, is one of the four priorities in the World Health Organization's comprehensive cancer program. Cancer has the highest incidence of pain, with at least 40% of patients with the condition experiencing pain. In patients with bone cancer, the growth of malignant tumors in the bone is accompanied by the invasion and compression of peripheral nerves, the release of inflammatory and tumor factors, and the changes in cell signaling pathways. These factors together lead to persistent and explosive pain in bon...

Examples

Embodiment 1

[0058] (1) Pulverize and sieve toad venom, Angelica dahurica, Glauber's salt, Myrrh and Asarum respectively;

[0059] (2) Put 4.0 parts of peony seed oil in the mixer, add 1.8 parts of myrrh prepared in step (1) and 1.8 parts of asarum prepared in step (1), stir while adding, and stir until fully mixed Homogenize to obtain the mixed drug;

[0060] (3) in the mixed medicine that step (2) makes, add the Radix Angelica dahuricae that 1.8 parts of steps (1) make, the methyl salicylate of 14.0 parts, 8.0 parts of steps (1) make, 8.0 parts of steps ( 1) The prepared Glauber's salt, 1.8 parts of mint ice and 1.8 parts of borneol were stirred while adding, and stirred until fully mixed to obtain a bone cancer analgesic composition;

[0061] (4) Add 27.0 parts of vaseline, 20.0 parts of lanolin and 3.0 parts of glycerin aqueous solution (the volume ratio of glycerin and water is 1:3) to the bone cancer analgesic composition prepared in step (3) to adjust the viscosity , stir evenly, ...

Embodiment 2

[0064] (1) Pulverize and sieve toad venom, Angelica dahurica, Glauber's salt, Myrrh and Asarum respectively;

[0065] (2) Put 5.0 parts of peony seed oil in a blender, add 2.0 parts of myrrh prepared in step (1) and 2.0 parts of asarum prepared in step (1), stir while adding, and stir until fully mixed Homogenize to obtain the mixed drug;

[0066] (2) in the mixed medicine that step (2) makes, add the Radix Angelica dahuricae that 2.0 parts of steps (1) make, the methyl salicylate of 16.0 parts, 10.0 parts of steps (1) make, 10.0 parts of steps ( 1) The prepared Glauber's salt, 2.0 parts of mint ice and 2.0 parts of borneol are stirred while adding, and stirred until fully mixed to obtain a bone cancer analgesic composition;

[0067] (4) Add 29.0 parts of vaseline, 22.0 parts of lanolin and 4.0 parts of glycerin aqueous solution (the volume ratio of glycerin and water is 1:3) to the bone cancer analgesic composition prepared in step (3) to adjust the viscosity , stir evenly,...

Embodiment 3

[0070] (1) Pulverize and sieve toad venom, Angelica dahurica, Glauber's salt, Myrrh and Asarum respectively;

[0071] (2) Put 6.0 parts of peony seed oil in a blender, add 2.2 parts of myrrh prepared in step (1) and 2.2 parts of asarum prepared in step (1), stir while adding, and stir until fully mixed Homogenize to obtain the mixed drug;

[0072] (3) add 2.2 parts of toad venom prepared in step (1), 18.0 parts of methyl salicylate, 12.0 parts of Angelica dahurica prepared in step (1), 12.0 parts of step (1) in the mixed medicine prepared in step (2). ) prepared Glauber's salt, 2.2 parts of mint ice and 2.2 parts of borneol, stirred while adding, and stirred until fully mixed to obtain a bone cancer pain-relieving composition;

[0073] (4) Add 31.0 parts of Vaseline, 24.0 parts of lanolin and 5.0 parts of aqueous glycerin (the volume ratio of glycerin and water is 1:3) to the bone cancer analgesic composition prepared in step (3) to adjust the viscosity , stir evenly, and le...

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