A blood collection device and its control equipment

Abstract

The present invention is applicable to the field of medical devices and provides a blood collection device and its control equipment. The blood collection device includes: a microneedle assembly, which includes a first microfluidic channel for releasing anesthetic and a second microfluidic channel for collecting blood; a first motion assembly for driving the microneedle assembly to inject anesthetic into the epidermal layer through the first microfluidic channel; a second motion assembly for driving the microneedle assembly to collect blood from the skin through the second microfluidic channel; and a blood storage device communicating with the second microfluidic channel for storing the collected blood. The blood collection device provided by the present invention is formed by arranging a plurality of microneedles with a small diameter in an orderly manner to form a microneedle array, and the wounds formed by the needles piercing the skin are tiny; and during the blood collection process, the penetration depth of the microneedles can be precisely controlled. Anesthetic is released when the microneedles penetrate the epidermal layer of the skin, and after anesthesia is completed, the microneedles penetrate into the dermis layer for blood extraction. Throughout the process, the patient will not feel pain, thus achieving painless blood collection.

Description

Technical Field

[0001] The present invention belongs to the field of medical devices, and particularly relates to a blood collection device and its control equipment. Background Art

[0002] Collecting blood to provide test samples is one of the routine detection means in clinical examinations. In the prior art, the commonly used blood collection methods are puncturing veins to collect blood, or pricking the finger tip, and then squeezing out and collecting the blood. This method is mostly used for regular blood glucose level detection in diabetic patients.

[0003] However, in the process of researching and practicing the prior art, the applicant of the present application found that the prior art has the following defects: Venipuncture for blood collection is usually more painful and generally requires professional medical staff to perform to reduce injuries; while the method of pricking the finger tip has a small blood collection volume and is also more painful. Moreover, for children, due to their fear of needles, they are reluctant to have their blood collected, which will undoubtedly increase the difficulty of blood collection work. Therefore, the above blood collection methods can no longer meet the needs of modern medicine. Summary of the Invention

[0004] An embodiment of the present invention provides a blood collection device and its control equipment, aiming to solve the problem that the existing blood collection methods such as venipuncture or pricking the finger tip still cause pain to the blood donors.

[0005] An embodiment of the present invention is implemented as follows. A blood collection device includes: a microneedle assembly, the microneedle assembly includes a first microfluidic channel for releasing anesthetic and a second microfluidic channel for collecting blood;

[0006] A first motion assembly for driving the microneedle assembly to inject anesthetic into the epidermal layer through the first microfluidic channel;

[0007] A second motion assembly for driving the microneedle assembly to collect blood from the skin through the second microfluidic channel;

[0008] A blood storage device communicating with the second microfluidic channel for storing the collected blood.

[0009] Another embodiment of the present invention also provides a blood collection device, which includes: a housing, and a microneedle hole array is provided on the bottom plate of the housing;

[0010] The following are placed inside the housing:

[0011] A microneedle assembly, the microneedle assembly includes a first microfluidic channel for releasing anesthetic and a second microfluidic channel for collecting blood;

[0012] A first motion component that drives the microneedle component to inject an anesthetic into the epidermis through the first microfluidic channel;

[0013] A second motion component that drives the microneedle component to collect blood from the skin through the second microfluidic channel;

[0014] The upper part of the housing has a cover that encapsulates the microneedle component, the first motion component, the second motion component, and the blood storage device into the housing;

[0015] The cover has:

[0016] Pressing holes corresponding to the first motion structure and the second motion structure;

[0017] A blood storage device that communicates with the second microfluidic channel and is used to store the collected blood.

[0018] An embodiment of the present invention also provides a blood collection control device, which includes: a control board;

[0019] A power supply connected to the control board;

[0020] A first motion component connected to the control board and capable of driving the first motion structure to move;

[0021] A second motion component connected to the control board and capable of driving the second motion structure to move;

[0022] A vacuum pump connected to the control board;

[0023] An installation position where a disposable blood collection device can be installed.

[0024] The blood collection device provided by the present invention is composed of a plurality of micro needles with a small diameter arranged in an orderly manner to form a microneedle array. When collecting blood, when the micro needles penetrate into the skin tissue of the blood donor, since the penetration depth of the micro needles is precisely controlled within the epidermis layer and does not touch the pain nerves, drugs such as anesthetics are rapidly released at this depth, and the skin wound is tiny. After the anesthesia is completed, the micro needles are again controlled to penetrate into the capillaries of the dermis layer for blood extraction, and the patient will not feel pain, thus achieving painless blood collection. Description of the Drawings

[0025] Figure 1 It is a schematic structural diagram of a blood collection device provided by an embodiment of the present invention;

[0026] Figure 2 It is a schematic structural diagram of an anesthetic storage device of a blood collection device provided by an embodiment of the present invention;

[0027] Figure 3 It is a schematic diagram of the microneedle array arrangement of a blood collection device provided by an embodiment of the present invention;

[0028] Figure 4 It is a schematic structural diagram of a substrate of a blood collection device provided by an embodiment of the present invention;

[0029] Figure 5 It is a sectional view of the C-C plane of a blood collection device provided by an embodiment of the present invention;

[0030] Figure 6 It is a schematic structural diagram of a flow guide plate of a blood collection device provided by an embodiment of the present invention;

[0031] Figure 7 It is an assembly drawing of a cover and a blood storage device of a blood collection device provided by an embodiment of the present invention;

[0032] Figure 8 It is a schematic structural diagram of a cover of a blood collection device provided by an embodiment of the present invention;

[0033] Figure 9 It is an internal structure assembly drawing of a blood collection device provided by an embodiment of the present invention;

[0034] Figure 10 It is a schematic structural diagram of a bottom plate of a blood collection device provided by an embodiment of the present invention;

[0035] Figure 11 It is a schematic diagram of the overall structure of another blood collection device provided by an embodiment of the present invention;

[0036] Figure 12 It is a schematic diagram of the structural modules of a blood collection control device provided by an embodiment of the present invention. Detailed implementation manners

[0037] In order to make the objectives, technical solutions and advantages of the present invention clearer and more understandable, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0038] The blood collection device provided by the embodiment of the present invention includes a microneedle assembly. The microneedle assembly includes a first microfluidic channel for releasing anesthetic and a second microfluidic channel for collecting blood; a first motion assembly for driving the microneedle assembly to inject anesthetic into the epidermal layer through the first microfluidic channel; a second motion assembly for driving the microneedle assembly to collect blood from the skin through the second microfluidic channel; and a blood storage device communicated with the second microfluidic channel for storing the collected blood. The microneedles in this blood collection device have a very small diameter, reaching the nanometer level. Therefore, when they penetrate the skin tissue of the blood donor, the skin wounds formed are very small, so the blood donor basically won't feel pain. Moreover, an anesthetic storage / release device is also provided in this blood collection device, which can control the depth to inject the anesthetic into the skin tissue of the blood donor in the epidermal layer without pain-sensing nerves during blood collection, and then pierce into the dermis layer to draw blood, so as to further achieve painless blood collection.

[0039] The following details the specific implementation of the present invention in conjunction with specific embodiments.

[0040] Combined with Figures 1 to 12 , in the embodiment of the present invention, the blood collection device includes: a microneedle assembly 1, the microneedle assembly 1 includes a first microfluidic channel 11 for releasing anesthetic and a second microfluidic channel 12 for collecting blood; a first motion assembly 2 for driving the microneedle assembly 1 to inject anesthetic into the epidermal layer through the first microfluidic channel 11; a second motion assembly 3 for driving the microneedle assembly 1 to collect blood from the skin through the second microfluidic channel 12; and a blood storage device 4 communicated with the second microfluidic channel 12 for storing the collected blood.

[0041] As an embodiment of the present invention, the first microfluidic channel 11 has a stepped channel with a larger upper diameter and a smaller lower diameter, and the end of the channel with a smaller diameter is close to the tip of the microneedle. The depth of the part of the channel with a smaller diameter can be set according to the depth of the dermal layer of the skin tissue of the blood donor. For example, the thickness of the dermal layer of the general human body is about 1.0 mm. Therefore, the depth of the microneedle channel of the part with a smaller diameter can be set to about 1.0 mm so that it can release the anesthetic to the epidermis layer of the human body, at a depth within about 200 μm, but not reaching the dermal layer containing capillaries at 200 μm - 1000 μm, so as not to puncture the capillaries or venous blood vessels in the skin tissue. The first microfluidic channel 11 with a stepped channel can control the flow rate of the anesthetic through the diameter of the stepped channel, that is, the flow rate of the anesthetic at the end with a larger diameter of the stepped channel is larger, and then the flow rate of the anesthetic flowing into the end with a smaller diameter of the stepped channel is relatively smaller. At this time, the flow rate of the anesthetic can change from large to small and can be slowly injected into the skin tissue of the blood donor, so that the local nerves of the blood donor are temporarily deprived of sensation, especially the sense of pain, to achieve painless blood collection. In addition, since the pore diameter of the microneedle is very small and can be manufactured at the nanoscale, when it penetrates into the skin tissue of the blood donor, the wound formed on the skin tissue of the blood donor is very small, and the penetration depth is generally not very deep, so the blood donor basically does not feel pain.

[0042] As a preferred embodiment of the present invention, the microneedles on the microneedle assembly 1 can be made of a degradable material with good toughness or good biocompatibility to improve the toughness of the microneedles with a small pore diameter and prevent the microneedles from being broken due to poor toughness during the blood collection process under pressure and remaining in the body of the blood donor, causing damage to the body of the blood donor. Or even if it remains, due to its biocompatibility and rapid degradability, it can avoid causing damage to the body of the blood donor.

[0043] In the embodiment of the present invention, the first microfluidic channel 11 includes: a hollow first microneedle array 111, an anesthetic storage device 112, and a channel 113 for injecting the anesthetic into the first microneedle array. The anesthetic storage device 112 includes: an anesthetic storage cavity 1121; an anesthetic release device 1122 located on the anesthetic storage cavity 1121; and a sealing structure 1123 for sealing the anesthetic into the anesthetic storage cavity 1121.

[0044] As an embodiment of the present invention, the hollow first microneedle array 111 may be a microneedle array fixedly disposed on a substrate 114. For example, the microneedle array may be a 10*10 square array, that is, a liquid injection microneedle array with 100 needles. Each microneedle is arranged in an orderly manner at a preset distance for liquid injection. On the back surface of the substrate 114 facing away from the first microneedle array 111, there is a joined liquid guide plate 115, and on the joint surface of the liquid guide plate 115 and the substrate 114, there are anesthetic diversion grooves 1151 and blood diversion grooves 1152, and on the opposite side of the joint surface of the liquid guide plate 115 and the substrate 114, there are sharp puncture needles 1125.

[0045] Among them, the puncture needle 1125 can be formed by injection molding, and the molding process is simple. However, the liquid guide plate 115 and the substrate 114 can be joined by various welding methods such as ultrasonic welding / hot melt welding / plasma welding / bonding, etc. The substrate 114 can be formed with internal stepped channels by a MEMS process.

[0046] In an embodiment of the present invention, the anesthetic storage cavity 1121 may be composed of two mutually connected liquid storage cavities with the same structure. Among them, the volume of each liquid storage cavity is about 5 - 150 uL, and both are used to store anesthetic. The volume of the two mutually connected cavities is about 10 - 300 uL, that is, about 10 - 300 uL of anesthetic can be stored at one time. The amount of anesthetic stored in the anesthetic storage cavity 1121 can fully meet the dosage requirements for anesthesia before blood collection, providing a prerequisite guarantee for painless blood collection. In addition, the two interconnected cavities can achieve a relatively balanced state when pressed, so that the puncture needle 1125 can pierce the soft film 1124 at the same time, and can also ensure that the time and depth of the microneedles invading the skin tissue of the blood donor are basically synchronized.

[0047] In an embodiment of the present invention, the anesthetic release device 1122 includes a soft film 1124 and a puncture needle 1125 disposed at the bottom of the anesthetic storage cavity 1121. When blood collection is performed, the soft film 1124 will be pierced by the puncture needle 1125, and the anesthetic stored in the anesthetic storage cavity 1121 can flow into the anesthetic diversion groove 1151 through the hollow channel of the puncture needle 1125, and then flow into the corresponding first microneedle array 111 channel through the anesthetic diversion groove 1151, and then be injected into the skin tissue of the blood donor through the first microneedle array 111 channel.

[0048] As an embodiment of the present invention, during the manufacturing of the blood collection device, anesthetic can be pre-injected into the anesthetic storage cavity 1121, and then sealed with a matching sealing structure 1123 to prevent the stored anesthetic from being contaminated by dust or other pollutants or spilling during transportation or storage.

[0049] As a preferred embodiment of the present invention, an opening 1126 can be formed in the center of the sealing structure 1123. After injecting and sealing the anesthetic into the anesthetic storage cavity 1121, the opening 1126 can be kept open to make the air pressure inside the anesthetic storage cavity 1121 relatively balanced with the external air pressure, so as to prevent the soft film 1124 from bulging downward and being punctured by the puncturing needle 1125 due to the pressure difference inside and outside the anesthetic storage cavity 1121 during the injection of the anesthetic, thus causing the anesthetic in the anesthetic storage cavity 1121 to be released in advance and resulting in waste.

[0050] As another preferred embodiment of the present invention, the sealing structure 1123 can be set as a boss structure with a protruding middle part. The opening 1126 is located on the boss, and the opening 1126 can be set as a funnel shape to facilitate the injection of the anesthetic and observe whether there is any overflow. In addition, the edge of the boss structure is an annular groove 1127. During the production process, if the anesthetic overflows, it can first flow into the annular groove 1127, and the overflowing anesthetic can be blown off with a spray gun, which can prevent the overflowing anesthetic from directly flowing into the interior of the blood collection device and maintain the overall sanitary and clean state of the blood collection device.

[0051] As another embodiment of the present invention, a safety distance is set between the soft film 1124 and the puncturing needle 1125. When injecting the anesthetic into the anesthetic storage cavity 1121, the soft film 1124 bulges downward under the action of pressure, and this safety distance can prevent the puncturing needle 1125 from directly puncturing the soft film 1124, resulting in liquid leakage, and can maintain the cleanliness and safety of the blood collection device.

[0052] In the embodiment of the present invention, the blood collection device can be provided with a matching sealing cover / sealing plug / sealing film (not shown in the figure) etc. on the opening 1126 to seal the opening 1126, so as to prevent the anesthetic from overflowing during storage, transportation and use and maintain its cleanliness and safety.

[0053] In an embodiment of the present invention, when it is necessary to release the anesthetic in the anesthetic storage cavity 1121 for anesthesia, the entire anesthetic storage cavity 1121 can be moved downward manually or mechanically controlled (such as: motor-driven), and the puncture needle 1125 can pierce the soft film 1124, so that the anesthetic in the anesthetic storage cavity 1121 can flow through the channel in the anesthetic release device 1122 to the hollow first micro-needle array 111, and be injected into the epidermal layer of the human skin tissue through the channel of the first micro-needle array 111 to achieve the anesthetic effect.

[0054] In an embodiment of the present invention, the second microfluidic channel 12 includes: a hollow second micro-needle array 121, which can transport the collected blood to a pipeline (not shown in the figure) of the blood storage device 4. Wherein, the second micro-needle array 121 can be fixedly arranged on the above-mentioned substrate 114, and the micro-needles in each row of the second micro-needle array 121 are arranged between every two rows of the first micro-needle array 111. Further, each micro-needle in the second micro-needle array 121 is located at the center of the square array formed by every four micro-needles of the first micro-needle array 111, that is, a Go-like structure is formed. The micro-needles in the second micro-needle array 121 can form a 9*9 square micro-needle array, that is, a micro-needle array with 81 micro-needles. When performing blood collection operation, the entire micro-needle assembly 1 moves downward, and drives the hollow first micro-needle array 111 and the hollow second micro-needle array 121 to move downward simultaneously. Wherein, during the downward movement, the anesthetic stored in the anesthetic storage cavity 1121 can flow into the first micro-needle array channel 113 through the hollow channel of the anesthetic release device 1122, and be injected into the human skin tissue through the first microfluidic channel 11 in the first micro-needle array 111 corresponding to the first micro-needle array channel 113.

[0055] However, the second microfluidic channel 12 in the second micro-needle array 121 can pierce into the epidermal layer of the human skin tissue accordingly, and as the external force increases, it can continue to penetrate into the dermis layer of the human skin tissue, puncture the capillary or venous blood vessels therein, cause bleeding and extract blood.

[0056] It should be noted that the arrangement of the micro-needles in the first micro-needle array 111 and the second micro-needle array 121 can also be other settings, for example, it can be set as a circular array with intervals, etc., which can be specifically set according to actual needs and will not be limited here.

[0057] In an embodiment of the present invention, the second micro-needle array 121 can extract about 7-8 uL at a time, that is, the blood collection device can collect about 600 uL of blood at one time. However, this amount of blood collection can already meet various common blood biochemical experiments.

[0058] In an embodiment of the present invention, the blood storage device 4 includes: a blood storage cavity 41; a blood injection channel 42 provided on the blood storage cavity 41, and a first one-way conduction structure (not shown in the figure) is provided on the blood injection channel 42; a blood discharge channel 43 provided on the blood storage cavity 41, and a second one-way conduction structure (not shown in the figure) is provided on the blood discharge channel 43; and a gas-permeable and water-impermeable part 44 provided on the blood storage cavity 41.

[0059] Among them, the first one-way conduction structure and the second one-way conduction structure can be a one-way valve structure, so that blood can only be injected along the blood injection channel 42 and flow out through the blood discharge channel 43, and cannot flow back into the human body reversely to cause damage to the human body, and ensure the smooth progress of blood extraction. In addition, the gas-permeable and water-impermeable part 44 provided on the blood storage cavity 41 can be a gas-permeable and water-impermeable film; during blood collection, the air staying in the blood storage cavity 41 can be pumped out by a device connected to the outside, such as a vacuum pump, through the film, so as to reduce the air content inside the blood storage cavity 41, that is, reduce its air pressure, so that a pressure difference is formed between the air pressure in the blood storage cavity 41 and the blood pressure of the human body, and the blood flowing out of the human body can be sucked into the blood storage cavity 41. However, the film is water-impermeable, which can prevent external moisture from entering the blood storage cavity 41 to dilute / contaminate the blood sample during blood collection / storage, that is, ensure the reliability of the blood sample, and is also a prerequisite for the authenticity and reliability of blood test results.

[0060] In an embodiment of the present invention, the first movement assembly 2 includes an elastic suspension bracket 21 provided on the housing 5 of the blood collection device to suspend the above-mentioned micro-needle assembly 1. The elastic suspension bracket 21 includes: a frame body 211 composed of elastic arms that can be pressed and deformed; and a limiting structure 212 that limits the movement of the micro-needle assembly 1 and drives the first micro-needle array 111 to enter the epidermal layer under the drive of a first movement structure (not shown in the figure).

[0061] In an embodiment of the present invention, the elastic suspension bracket 21 can clamp the four end corners of the micro-needle assembly 1 through clamping structures provided at its ends respectively to fixedly suspend the micro-needle assembly 1. Among them, the clamping structure can be a structure that bends inwardly extended from the two open ends of the frame body 211, or a snap structure formed by the cooperation of the open ends of the two elastic arms of the frame body 211 and the micro-needle assembly 1, etc.

[0062] In a preferred embodiment of the present invention, the frame body 211 can be an obtuse-angle structure composed of two elastic arms. When a first external force is applied to the obtuse-angle vertex of the frame body 211, elastic deformation can occur, and the angle of the obtuse angle becomes larger. At this time, the microneedle assembly 1 can be driven to move downward. When the microneedle assembly 1 moves downward, the first microfluidic channel 11 on the first microneedle array 111 can enter the epidermis of the human body, and at this time, it stops further penetration due to the resistance of the limiting structure 212. At this time, the retention time of the first external force can be set so that the anesthetic can be injected into the epidermis of the human body through the anesthetic release device 1122 and the first microfluidic channel 11 on the first microneedle array 111, and the anesthetic effect can be exerted within the retention time of the first external force. Then, a second pressure can be continuously applied to the frame body 211 so that the limiting structure 212 also undergoes elastic deformation. At this time, the second microfluidic channel 12 on the second microneedle array 121 in the microneedle assembly 1 can further penetrate into the dermis of the human skin tissue, puncture the human vein or capillary, cause blood to flow out, and blood collection can be performed. Since an anesthetic is injected before blood collection and the diameter of the microneedles is very small, the blood donor can hardly feel pain, so painless blood collection can be achieved.

[0063] It should be noted that in actual applications, the retention time and magnitude of the first pressure / second pressure can be flexibly set according to differences in factors such as the age of the blood donor, the blood collection site, and the pain sensitivity of the blood collection site. For example, when the blood collection site is not sensitive to pain, the magnitudes of the first pressure and the second pressure can be set slightly larger and the retention time can be shorter; the second pressure can be slightly larger. For another example, when the blood donor is young and the skin tissue is delicate, the magnitudes of the first pressure and the second pressure can be appropriately set smaller and the retention time can be slightly shorter.

[0064] In an embodiment of the present invention, the first microneedle array 111 and the second microneedle array 121 may be composed of retractable microneedles, and the first microneedle array 111 and the second microneedle array 121 may not penetrate the skin tissue simultaneously under the action of an external force. That is, when the elastic suspension bracket 21 is subjected to a first pressure, the microneedle assembly 1 moves downward, driving the first microfluidic channel 11 on the first microneedle array 111 to move downward and penetrate into the skin tissue of the human body, while the second microfluidic channel 12 on the second microneedle array 121 contracts and does not penetrate the skin. When the elastic suspension bracket 21 is subjected to a second pressure, the microneedle assembly 1 continues to move downward. At this time, the first microfluidic channel 11 on the first microneedle array 111 retracts, and the second microfluidic channel 12 on the second microneedle array 121 extends and penetrates into the dermis layer of the skin tissue. Of course, depending on differences in the blood collection site, etc., when receiving the second pressure, the first microfluidic channel 11 on the first microneedle array 111 can also continue to penetrate deeper to further release an anesthetic at the blood collection site to achieve better painless blood collection.

[0065] In an embodiment of the present invention, the second movement assembly 3 of the blood collection device includes: a pressing assembly 31 for releasing the limiting structure 212. Among them, the pressing assembly may be a pressing structure composed of a protrusion 2121 on the limiting structure 212 and a groove / hole 311 on the bottom plate 51 of the blood collection device that cooperates with the protrusion 2121. When assembling the blood collection device, the limiting structure 212 can be fixed to the blood collection device through the cooperation of its protrusion 2121 and the groove / hole 311 on the bottom plate 51. When the blood collection is over or when the blood collection device needs to be disassembled, the protrusion 2121 can be pressed to separate the protrusion 2121 from the groove / hole 311, that is, release the limiting structure 212, and at this time the microneedle assembly 1 can leave the skin tissue.

[0066] An embodiment of the present invention also provides another blood collection device, which includes: a housing 5, on the bottom plate 51 of the housing 5, a microneedle hole array 511 is provided; inside the housing 5, there is placed: a microneedle assembly 1, the microneedle assembly 1 includes a first microfluidic channel 11 that can release an anesthetic, and a second microfluidic channel 12 that can collect blood; a first movement assembly 2 that drives the microneedle assembly 1 to inject an anesthetic into the epidermal layer through the first microfluidic channel 11; a second movement assembly 3 that drives the microneedle assembly 1 to collect blood from the skin through the second microfluidic channel 12; on the upper part of the housing 5, there is a cover 7 that encapsulates the microneedle assembly 1, the first movement assembly 2, the second movement assembly 3, and the blood storage device 4 into the housing 5; on the cover 7, there are: pressing holes 71 corresponding to the first movement structure 6 and the second movement structure 8; a blood storage device 4 that communicates with the second microfluidic channel 12 and is used to store the collected blood.

[0067] In an embodiment of the present invention, the cover 7 further has a positioning hole / dowel 72, so that it can be fixed on the housing 5 through the positioning hole / dowel 72, to prevent the cover 7 from slipping out of the housing 5 during transportation, storage, or sales, etc., and to prevent the components inside the housing 5 from being contaminated by external dust and other pollutants.

[0068] In an embodiment of the present invention, a protective film (not shown in the figure) is also attached to the side of the bottom plate 51 of the housing 5 that contacts the skin, which can prevent dust and other pollutants from adhering to the bottom plate 51 of the blood collection device, or prevent pollutants from entering the interior of the blood collection device through the microneedle array holes 511 on the bottom plate 51. When collecting blood, dust and other pollutants may infect the human body from the part in contact with the human body. Therefore, the hygiene and safety of the blood collection device can be further ensured.

[0069] In an embodiment of the present invention, the blood storage device 4 includes: a blood storage cavity 41; a first pipe joint 45 and a second pipe joint 46 disposed on one side of the blood storage cavity 41 and connected to the second micro-control flow channel 12 through a catheter (not shown in the figure); a first one-way conduction structure (not shown in the figure) and a second one-way conduction structure (not shown in the figure) respectively connected to the first pipe joint 45 and the second pipe joint 46; on the opposite side of the blood storage cavity 41, a reverse one-way conduction structure (not shown in the figure) is disposed at a position corresponding to the second one-way conduction structure; on the opposite side of the blood storage cavity 41, a blood extraction hole 47 is disposed at a position corresponding to the first one-way conduction structure, and a gas-permeable and water-impermeable part 44 is installed on the blood extraction hole 47; the gas-permeable and water-impermeable part 44 can be connected to a vacuum pump 11 of an external device; on the opposite side of the blood storage cavity 41, a blood discharge hole 48 communicating with the reverse one-way conduction structure is disposed at a position corresponding to the reverse one-way conduction structure; the open end of the blood storage cavity 41 is sealed with a flexible film; wherein, a rigid thin plate (not shown in the figure) is attached to the outer side of the flexible film.

[0070] In an embodiment of the present invention, the gas-permeable and water-impermeable part 44 installed on the blood extraction hole 47 can allow gas to pass through but not water. The external device vacuum pump 11 of the blood collection device can extract the air in the blood storage cavity 41 through the gas-permeable and water-impermeable part 44, so that it is in a negative pressure / vacuum environment. The human blood flows into the blood storage cavity 41 due to the pressure difference, thereby realizing rapid blood collection, shortening the blood extraction time and reducing the pain of the human body. The gas-permeable and water-impermeable part 44 can block the entry of external water into the blood storage cavity 41, diluting or contaminating the collected blood sample. Among them, the gas-permeable and water-impermeable part 44 can be a gas-permeable and water-impermeable film.

[0071] In an embodiment of the present invention, the opening end of the blood storage cavity 41 is sealed with a flexible film, and a rigid thin plate is attached to the outer side of the flexible film. The rigid thin plate can further prevent the blood sample in the blood storage cavity 41 from splashing due to external force impact during blood collection. And using a flexible film to seal between the rigid thin plate and the blood storage cavity 41 can separate the blood storage cavity 41 from the rigid thin plate and completely seal the opening end of the blood storage cavity 41, preventing contaminants from entering the interior of the blood storage cavity 41 through the edge gap of the rigid thin plate, thereby further ensuring that the collected blood sample is not contaminated.

[0072] In an embodiment of the present invention, a chute 73 for connecting with an external device is provided on the cap 7 of the blood collection device, so that the blood collection device can be slidably pushed and pulled in cooperation with the external device through the chute 73, similar to a drawer-like structure, improving the convenience of use of the blood collection device.

[0073] An embodiment of the present invention also provides a blood collection control device, which includes: a control board 9; a power supply 10 connected to the control board 9; a first motion component 2 connected to the control board 9 and capable of driving the first motion structure 6 to move; a second motion component 3 connected to the control board 9 and capable of driving the second motion structure 8 to move; a vacuum pump 11 connected to the control board 9; and an installation position for installing a disposable blood collection device. Among them, the first motion component 2 and the second motion component 4 are respectively composed of a linear motor capable of performing a linear pressing motion and affiliated mechanisms.

[0074] Among them, in an embodiment of the present invention, the linear motor can directly convert electrical energy into mechanical energy of linear motion without a transmission device of other intermediate conversion mechanisms, and it has the advantages of high positioning accuracy, simple structure, stable motion, low noise, and small friction of moving parts.

[0075] In an embodiment of the present invention, the device further includes a display screen 12 connected to the control board 9. Through the display screen 12, the current blood collection process can be displayed. For example, data such as the current dosage of anesthetic used, the residence time of injecting the anesthetic, the volume of blood collection, the blood collection site, and the needle insertion depth can be displayed on the display screen 12, so as to remind the blood collection staff to make adjustments or end the blood collection work, improving the efficiency and accuracy of blood collection.

[0076] In an embodiment of the present invention, the device further includes a sound playing device 13 connected to the control panel 9, which can be used to play the process data of blood collection during blood collection, for example, playing the injection time of the anesthetic, the injection dose of the anesthetic, the depth of the microneedle penetrating the skin, the blood flow and other sound data, so as to prompt the blood collector to make timely adjustments to the abnormal conditions of blood collection and end the blood collection operation, or to instruct non-professional blood collectors to perform the correct blood collection operation steps. For example, diabetics can perform blood collection operations and test blood sugar levels at home according to the blood collection operation steps played by the blood collection device. That is, the wide use and convenience of the blood collection device can be further improved.

[0077] In an embodiment of the present invention, the device further includes a start switch 14 connected to the control panel 9. When blood sampling is required, the control panel 9 can control the opening and closing of the start switch 14 to drive the blood sampling device to perform blood sampling or stop the blood sampling operation.

[0078] In an embodiment of the present invention, a positioning pin / positioning hole 72 corresponding to the positioning hole / positioning pin on the blood collection device is provided on the mounting position of the device, so that the blood collection device can be fixedly installed on the mounting position, thereby preventing the blood collection device from moving and pulling the skin tissue of the blood collector during blood collection, causing pain; or the blood collection device is not installed in place and cannot perform normal blood collection operations.

[0079] In an embodiment of the present invention, the device also includes a blood collection device release switch (not shown in the figure). When blood collection is completed or an abnormal situation occurs during the blood collection process, the blood collection staff can press the release switch to disengage the positioning pin / positioning hole from the positioning hole / positioning pin of the blood collection device, thereby stopping the blood collection operation, thereby ensuring the safety of blood collection and facilitating the blood collection staff to make timely adjustments to abnormalities that occur during the blood collection process.

[0080] In an embodiment of the present invention, the device further includes a fixing structure (not shown in the figure) that can fix the device to the arm. The fixing structure can be a bandage, Velcro, buckle structure, etc. During blood collection, the blood collection device can be fixed to the arm of the person whose blood is being collected by the fixing structure, and the blood collection device can be prevented from shifting during the blood collection process and involving the skin tissue of the person whose blood is being collected, thereby increasing the pain, thereby further improving the convenience of using the blood collection device.

[0081] In an embodiment of the present invention, the device can be configured in a watch-like structure, and the device is small in size and can be made into the size of a USB flash drive with a length × width of 50×18. The whole device is very compact and can be worn on the hand for blood collection, which is very convenient. Moreover, when using the blood collection device with this watch-like structure for blood collection, the microneedles provided inside the device cannot be seen throughout the process, which can reduce the fear of needles of the blood donors (especially children). Therefore, to a certain extent, this can reduce the difficulty of blood collection for the blood collection workers due to the resistance of the blood donors. In addition, during the blood collection process, no blood can be seen during the process of the blood collection device extracting blood. For some blood donors who are afraid of blood, they can also easily complete the blood collection.

[0082] In an embodiment of the present invention, the device further includes an attention diversion device 15 connected to the control board 9. The attention diversion device 15 can be a video / music player, a picture display, a game console, an aroma release device, etc. During blood collection, some videos / music, pictures, games, etc. can be played simultaneously to attract the attention of the blood donors, so that the blood donors (especially children) can easily complete blood extraction during the process of watching videos, pictures or playing games without crying, reducing the trouble of blood collection for the blood collection workers.

[0083] The blood collection device provided by the present invention is composed of a microneedle array formed by arranging multiple microneedles with a very small diameter (nanoscale) in an orderly manner. When the microneedles penetrate into the skin tissue of the blood donor, the skin wounds formed are very small, and the blood donor basically does not feel pain. Moreover, an anesthetic storage / release device is also provided. During blood collection, the anesthetic can be released into the epidermis of the skin tissue of the blood donor through the release device, and then blood extraction can be carried out after anesthesia is completed, so that painless blood collection can be further achieved. In addition, the blood collection device has a disposable and detachable structure, which is convenient for installation and use, effectively ensuring that there will be no cross-contamination of blood among blood donors due to sharing blood collection needles, etc., and at the same time ensuring that the collected blood sample is not contaminated and affecting the final judgment of the test results.

[0084] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A blood collection device, characterized in that, The blood collection device includes: A housing, on the bottom plate of which a microneedle hole array is provided; Placed inside the housing are: A microneedle assembly, which includes a first microfluidic channel for releasing anesthetic and a second microfluidic channel for collecting blood; the first microfluidic channel has a stepped channel with a larger diameter at the top and a smaller diameter at the bottom, and the channel with the smaller diameter is close to the tip of the microneedle; A first motion assembly for driving the microneedle assembly to inject anesthetic into the epidermal layer through the first microfluidic channel; A second motion assembly for driving the microneedle assembly to collect blood from the skin through the second microfluidic channel; At the upper part of the housing, there is a cover for encapsulating the microneedle assembly, the first motion assembly, the second motion assembly and the blood storage device into the housing; On the cover, there are: pressing holes corresponding to the first motion structure and the second motion structure; a blood storage device communicating with the second microfluidic channel for storing the collected blood; there is also a positioning pin hole / pin on the cover; a sliding groove for connecting with an external device is provided on the cover; The first microfluidic channel includes: a hollow first microneedle array, an anesthetic storage device and a channel for injecting anesthetic into the first microneedle array. Among them, the anesthetic storage device includes an anesthetic storage cavity, an anesthetic release device located on the storage cavity and a sealing structure for sealing anesthetic into the storage cavity; the anesthetic storage cavity is composed of two mutually connected and identical liquid storage cavities, and the anesthetic release device includes a soft film and a puncture needle arranged at the bottom of the anesthetic storage cavity; The blood storage device includes: a first pipe joint and a second pipe joint arranged on one side of the blood storage cavity and communicating with the second micro-control flow channel through a catheter; a first one-way conduction structure and a second one-way conduction structure respectively connected to the first pipe joint and the second pipe joint; on the opposite side of the blood storage cavity, at a position corresponding to the second one-way conduction structure, a reverse one-way conduction structure is provided; on the opposite side of the blood storage cavity, at a position corresponding to the first one-way conduction structure, a blood extraction hole is provided, and a gas-permeable and water-impermeable part is installed on the blood extraction hole; the gas-permeable and water-impermeable part can be connected to a vacuum pump of an external device; on the opposite side of the blood storage cavity, at a position corresponding to the reverse one-way conduction structure, a blood discharge hole communicating with the reverse one-way conduction structure is provided; the open end of the blood storage cavity is sealed with a flexible film; a rigid thin plate is attached to the outside of the flexible film.

2. The blood collection device according to claim 1, characterized in that, A protective film is attached to the side of the bottom plate of the housing that contacts the skin.

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