Ion mobility spectrometer based on pulse sampling

Abstract

The embodiment of the present disclosure provides an ion mobility spectrometer device based on pulse sampling. The ion mobility spectrometer device includes: an ion mobility spectrometer configured to detect a sample; a sampling device configured to collect the sample and output a mixed gas containing the sample; and a circulating gas circuit configured to connect the sampling device with the ion mobility spectrometer fluid so as to introduce the mixed gas containing the sample output by the sampling device into the ion mobility spectrometer, and to be able to return at least part of the gas discharged by the ion mobility spectrometer to the ion mobility spectrometer and / or the sampling device.

Description

Technical Field

[0001] Embodiments of the present disclosure relate to the field of ion migration, and in particular to an ion migration spectrometer device based on pulse sampling. Background Art

[0002] Ion mobility spectrometry (IMS) has the advantages of portability, rapidity, sensitivity and industrialization, and is widely used in military, national defense, industry, environment and clinical diagnosis. However, due to the interference of other complex matrices in the detection environment, such as water vapor, its qualitative and quantitative identification capabilities are greatly limited. Summary of the invention

[0003] According to one aspect of the present disclosure, an embodiment of the present disclosure provides an ion mobility spectrometer device based on pulse sampling, comprising:

[0004] an ion mobility spectrometer configured to detect the sample;

[0005] a sampling device configured to collect a sample and output a mixed gas containing the sample; and

[0006] The circulating gas circuit is configured to connect the sampling device with the ion mobility spectrometer fluid so as to introduce the mixed gas containing the sample output by the sampling device into the ion mobility spectrometer, and to be able to return at least part of the gas discharged by the ion mobility spectrometer to the ion mobility spectrometer and / or the sampling device.

[0007] In one embodiment, the circulating gas circuit is configured to allow the ion mobility spectrometer device to switch between a sampling and injection state and a first gas internal circulation state.

[0008] wherein in the sampling and injection state, the sampling device collects a sample and delivers the sample to the ion mobility spectrometer as a mixed gas containing the sample through gas for detection, and a portion of the gas exhausted from the ion mobility spectrometer is returned to the sampling device after filtering / purification to form a mixed gas containing the sample with the sample so as to transport the sample; and

[0009] In the first gas internal circulation state, the fluid connection between the sampling device and the ion mobility spectrometer is disconnected, and the gas exhausted from the ion mobility spectrometer is sent back to the ion mobility spectrometer after being filtered / purified.

[0010] In one embodiment, the ion mobility spectrometer device further comprises a first two-position three-way valve, which is fluidically connected between the sampling device in the circulation gas circuit and the ion mobility spectrometer and is configured to:

[0011] In the sampling and injection state, the sampling device and the ion mobility spectrometer are allowed to be fluidically connected, and the gas enters the first two-position three-way valve from the first inlet of the first two-position three-way valve, leaves the first two-position three-way valve from the outlet of the first two-position three-way valve, and is sent to the ion mobility spectrometer; and in the first gas internal circulation state, the fluid connection between the sampling device and the ion mobility spectrometer is disconnected, and the gas discharged from the ion mobility spectrometer is allowed to be sent back to the ion mobility spectrometer through the second inlet of the first two-position three-way valve after filtering / purification.

[0012] In one embodiment, the ion mobility spectrometer includes a first inlet of the ion mobility spectrometer, which is configured to communicate with the first two-position three-way valve so that the gas enters the ion mobility spectrometer from the first inlet of the ion mobility spectrometer after leaving the first two-position three-way valve.

[0013] In one embodiment, the circulation gas circuit is configured to allow the ion mobility spectrometer device to switch between a sampling and injection state, a first gas internal circulation state, and a sampling device cleaning state.

[0014] Wherein, in the state of the cleaning sampling device, the gas exhausted from the ion mobility spectrometer is sent to the sampling device after being filtered / purified, and is exhausted from the sampling device in the reverse direction of the sampling device after passing through the sampling device.

[0015] In one embodiment, the ion mobility spectrometer device further comprises a second two-position three-way valve (105B), which is fluidically connected between the ion mobility spectrometer and the sampling device in the circulation gas circuit and is directly connected to the sampling device, and the second two-position three-way valve is configured as follows:

[0016] In the sampling and injection state, the gas exhausted from the ion mobility spectrometer is directly sent to the sampling device through the second two-position three-way valve after being filtered / purified, the gas is mixed with the sample to form a mixed gas containing the sample and sent to the ion mobility spectrometer, and a part of the gas exhausted from the ion mobility spectrometer is sent back to the sampling device through the second two-position three-way valve as a carrier gas after being filtered / purified;

[0017] In the state of cleaning the sampling device, the gas exhausted from the ion mobility spectrometer is sent to the sampling device instead of the ion mobility spectrometer through the first outlet of the second two-position three-way valve after being filtered / purified, and passes through the sampling device so as to clean the sampling device; and

[0018] When the first gas is in the internal circulation state, the fluid connection between the ion mobility spectrometer and the sampling device is disconnected, and part of the gas exhausted by the ion mobility spectrometer is sent back to the ion mobility spectrometer through the second outlet of the second two-position three-way valve after filtering / purification, and the gas does not pass through the sampling device.

[0019] In one embodiment, the circulating gas circuit includes a first internal circulating sub-gas circuit, and the gas exhausted from the ion mobility spectrometer is sent back to the ion mobility spectrometer via the first internal circulating sub-gas circuit; the first internal circulating sub-gas circuit is: after the gas is exhausted from the ion mobility spectrometer, it enters from the inlet of the second two-position three-way valve, is discharged from the second outlet of the second two-position three-way valve, is sent to the first two-position three-way valve, and is then sent back to the ion mobility spectrometer.

[0020] In one embodiment, the circulating gas circuit includes a first buffer tank having a certain gas volume, configured to be in fluid communication with the ion mobility spectrometer so as to receive gas exhausted from the ion mobility spectrometer and allow the gas exhausted from the first buffer tank to be fed into the ion mobility spectrometer.

[0021] In one embodiment, the circulation gas circuit comprises a filter, and is configured to allow the gas exhausted from the ion mobility spectrometer to at least pass through the filter in the circulation gas circuit, so as to filter / purify the gas.

[0022] In one embodiment, the circulation gas circuit comprises a pump configured to drive gas in the circulation gas circuit to leave the ion mobility spectrometer and flow in the circulation gas circuit.

[0023] In one embodiment, the circulating gas circuit includes a second buffer tank having a certain gas volume, configured to receive the gas from the first buffer tank and allow at least a portion of the gas exhausted from the second buffer tank to be fed into the ion mobility spectrometer.

[0024] In one embodiment, the second buffer tank is capable of receiving gas from the first buffer tank, and a portion of the gas discharged from the second buffer tank is sent to the ion mobility spectrometer, and another portion is sent to the inlet of the second two-position three-way valve.

[0025] In one embodiment, the ion mobility spectrometer further comprises a first outlet and / or a second outlet configured to discharge the gas in the ion mobility spectrometer; and a first circulation inlet and / or a second circulation inlet configured to circulate the gas into the ion mobility spectrometer; and

[0026] The circulating gas circuit includes a second inner circulating sub-gas circuit, which is configured such that the gas discharged from the first outlet and / or the second outlet of the ion mobility spectrometer at least passes through the filter, and then a portion of the gas is sent into the ion mobility spectrometer through the first circulating inlet and / or the second circulating inlet of the ion mobility spectrometer. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 A schematic diagram showing an ion mobility spectrometer device according to an embodiment of the present disclosure. DETAILED DESCRIPTION

[0028] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. The following description of at least one exemplary embodiment is actually only illustrative and is by no means intended to limit the present invention and its application or use. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without carrying out creative work are within the scope of protection of the present invention.

[0029] Technologies, methods, and apparatus known to ordinary technicians in the relevant field may not be discussed in detail, but where appropriate, such technologies, methods, and apparatus should be considered part of the authorization specification.

[0030] In the description of the present invention, it is necessary to understand that the directions or positional relationships indicated by directional words such as "front, back, up, down, left, right", "lateral, vertical, perpendicular, horizontal" and "top, bottom" are usually based on the directions or positional relationships shown in the drawings. They are only for the convenience of describing the present invention and simplifying the description. Unless otherwise specified, these directional words do not indicate or imply that the devices or elements referred to must have a specific direction or be constructed and operated in a specific direction. Therefore, they cannot be understood as limiting the scope of protection of the present invention. The directional words "inside and outside" refer to the inside and outside relative to the contours of each component itself.

[0031] In the description of the present invention, it should be understood that the use of terms such as "first" and "second" to limit components is only for the convenience of distinguishing the corresponding components. Unless otherwise stated, the above terms have no special meaning and therefore cannot be understood as limiting the scope of protection of the present invention.

[0032] Various embodiments according to the present disclosure are described below with reference to the accompanying drawings.

[0033] The embodiment of the present disclosure provides an ion mobility spectrometer device based on pulse sampling, including: an ion mobility spectrometer 101, configured to detect samples; a sampling device 106, configured to collect samples and output a mixed gas containing the samples; and a circulating gas path, configured to connect the sampling device 106 to the ion mobility spectrometer 101 fluid, so as to introduce the mixed gas containing the sample output by the sampling device 106 into the ion mobility spectrometer 101, and to be able to return at least part of the gas discharged by the ion mobility spectrometer 101 to the sampling device 106 and / or the ion mobility spectrometer 101. It should be known that a gas-tight gas path is formed between the sampling device 106 and the ion mobility spectrometer 101 using various similar tubes such as glass tubes, steel tubes, and connecting tubes, i.e., a circulating gas path. The circulating gas path includes multiple gas flow paths to achieve multiple functions. In the subsequent embodiments, it is assumed that even if the existence of a pipeline is not stated, the pipeline exists in order to achieve gas transportation.

[0034] In one embodiment, the circulating gas circuit is configured to allow the ion mobility spectrometer device to switch between a sampling and injection state and a first gas internal circulation state. In this embodiment, in the sampling and injection state, the sampling device 106 collects a sample and sends the sample into the ion mobility spectrometer 101 as a mixed gas containing the sample by suction of a pump, and a portion of the gas exhausted from the ion mobility spectrometer 101 is returned to the sampling device 106 (for example, as a carrier gas) after filtering / purification to form a mixed gas containing the sample with the sample in order to transport the sample; in the first gas internal circulation state, the fluid connection between the sampling device 106 and the ion mobility spectrometer 101 is disconnected, and the gas exhausted from the ion mobility spectrometer 101 is returned to the ion mobility spectrometer 101 after filtering / purification.

[0035] In one embodiment, the sampling and injection state includes a sampling device cleaning state. In the sampling device cleaning state, the sampling device 106 does not collect samples, gas is sent into the sampling device 106, the gas passes through the sampling device 106 to clean the sampling device 106, and finally can be discharged from the sampling device 106 to the ion mobility spectrometer device. For example, the sampling device 106 may include a sampling head 1060, and the gas is discharged from the sampling head 1060. In other words, in the sampling and injection state, the sampling device 106 is in a working state, and the gas sent into the sampling device 106 (at this time used as an injection carrier gas) will mix with the collected sample to form a mixed gas containing the sample; in the sampling device cleaning state, the gas is still sent into the sampling device 106, however, the sampling device does not collect samples at this time, the gas flows in the sampling device 106 to automatically clean the sampling device 106, and is discharged from the sampling head. The ion mobility spectrometer device according to this embodiment can thus realize the switching of the working state of collecting samples and the cleaning of the sampling device, and the operation is convenient. In addition, since the gas exhausted from the ion mobility spectrometer 101 can be recycled (i.e., the first gas internal circulation state), there is no need for an external or internal gas tank to provide gas, which saves gas materials, simplifies the entire device, improves portability, and reduces detection costs.

[0036] The sampling device 106 can be a gas sampling device or a solid sampling device. For example, in one embodiment, the sampling device 106 can use a stainless steel tube with a certain strength (with an outer diameter not exceeding 5 mm), and a temperature control function is set at the sampling head 1060, so that the stainless steel tube can work at a specific temperature, which is convenient for cleaning the residual sample therein, and a microporous filter is also set at the front end of the sampling head 1060 to prevent dust or particles from clogging the sampling pipeline during the sampling process.

[0037] The ion mobility spectrometer 101 may be, for example, a positive and negative dual-mode ion mobility tube, such as an integrated ceramic dual-mode mobility tube. The ion mobility spectrometer 101 may also be a positive or negative single-mode ion mobility tube.

[0038] In one embodiment of the present disclosure, the ion mobility spectrometer device based on pulse sampling includes a first two-position three-way valve 105A, which is fluidically connected between the sampling device 106 in the circulating gas circuit and the ion mobility spectrometer 101. Here, it can be understood that along the gas flow direction, the first two-position three-way valve 105A is downstream of the sampling device 106 and upstream of the ion mobility spectrometer 101.

[0039] The first two-position three-way valve 105A is configured to: in the sampling and injection state, allow the sampling device 106 and the ion mobility spectrometer 101 to be fluidically connected, that is, the gas enters the first two-position three-way valve 105A from the first inlet 105A1 of the first two-position three-way valve 105A, leaves the first two-position three-way valve 105A from the outlet 105A3 of the first two-position three-way valve 105A, and is sent to the ion mobility spectrometer 101; and in the first gas internal circulation state, the sampling device 106 The fluid connection with the ion mobility spectrometer 101 is disconnected, and the gas discharged from the ion mobility spectrometer 101 is allowed to be sent back to the ion mobility spectrometer 101 through the first two-position three-way valve 105A after filtering / purification, that is, the gas enters the first two-position three-way valve 105A from the second inlet 105A2 of the first two-position three-way valve 105A, leaves the first two-position three-way valve 105A from the outlet 105A3 of the first two-position three-way valve 105A, and is sent to the ion mobility spectrometer 101. The first two-position three-way valve 105A is set to greatly facilitate the switching of the operating state of the ion mobility spectrometer device, and fast sampling, injection and gas circulation can be achieved through a two-position three-way valve. By controlling the first two-position three-way solenoid valve 105A, the time for fast connection and disconnection of the gas path for sampling can be shortened, and pulse sampling can be achieved. For example, the pulse injection time can be as low as milliseconds, and the minimum sampling volume of a single pulse can be as low as microliters (such as sampling gas flow 1L / min). This direct sampling method of millisecond or hundreds of millisecond pulse sampling can not only improve the sensitivity of trace sniffing but also minimize the impact of harsh external detection environment on the accuracy of ion migration detection.

[0040] In one embodiment, the ion mobility spectrometer 101 includes a first inlet 1011 of the ion mobility spectrometer, which is configured to be connected to the first two-position three-way valve 105A, and the gas enters the ion mobility spectrometer 101 from the first inlet 1011 of the ion mobility spectrometer after leaving the outlet 105A3 of the first two-position three-way valve. In the first gas internal circulation state, after the gas of the ion mobility spectrometer 101 is discharged, it is filtered or cleaned, enters the first two-position three-way valve 105A from the second inlet 105A2 of the first two-position three-way valve 105A, and then leaves the outlet 105A3 of the first two-position three-way valve 105A, and enters the ion mobility spectrometer 101 through the first inlet 1011 of the ion mobility spectrometer. It should be noted that the ion mobility spectrometer device of this embodiment also includes other components and connecting pipes.

[0041] In one embodiment, the circulating gas circuit is configured to allow the ion mobility spectrometer device to switch between a sampling and injection state, a first gas internal circulation state, and a clean sampling device state. In the clean sampling device state, the gas discharged from the ion mobility spectrometer 101 is sent to the sampling device 106 after filtering / purification, and after passing through the sampling device 106, it is discharged from the sampling device 106 in the reverse direction of the sampling device 106. It is explained here that when the sampling device 106 samples, the sample can, for example, flow from the left side of the sampling device 106 in the figure to the right side, and the reverse direction of the sampling device 106 refers to flowing from the right side of the sampling device 106 in the figure to the left side. That is, the gas discharged from the ion mobility spectrometer 101 is sent to the sampling device 106 after filtering / purification, and then flows from the right side of the sampling device 106 to the left side, and is discharged from the injection inlet of the sampling device 106 (for example, the inlet of the sampling head of the sampling device 106). Through this process, the gas flows through the sampling device 106 and is directly discharged from the sampling end of the sampling device 106, thereby cleaning the sampling device 106 and the sampling pipeline. When sampling again, there is no influence of the sample residue from the previous sampling on the current sampling detection.

[0042] In one embodiment, the ion mobility spectrometer device includes a pump 103, which is configured to drive the gas in the circulating gas circuit to leave the ion mobility spectrometer 101 and flow in the circulating gas circuit. It is advantageous to provide the pump 103, because the pump 103 drives the gas to flow in the circulating gas circuit, so that a negative pressure can be formed at the sampling head 1060 of the sampling device 106, and the sample is sucked into the sampling device 106 by the negative pressure. During the operation of the ion mobility spectrometer device, the pump 103 can be kept running, so that the gas keeps circulating, and the operation of starting or stopping sampling is performed by adjusting the first two-position three-way valve 105A.

[0043] In one embodiment, the ion mobility spectrometer device further comprises a second two-position three-way valve ( 105B), which is fluidically connected between the ion mobility spectrometer 101 and the sampling device 106 in the circulation gas circuit and is directly connected to the sampling device 106 .

[0044] The second two-position three-way valve 105B is also configured as follows: in the sampling and injection state, the gas discharged from the ion mobility spectrometer 101 is directly sent to the sampling device 106 through the second two-position three-way valve 105B after being filtered / purified, and the gas is mixed with the sample to form a mixed gas containing the sample, which is sent to the ion mobility spectrometer 101 for analysis; and a part of the gas discharged from the ion mobility spectrometer 101 is sent back to the sampling device 106 as a carrier gas through the second two-position three-way valve 105B after being filtered / purified. In this embodiment, the gas from the second two-position three-way valve 105B is sent to the gas inlet 1062 of the sampling device 106, and the gas inlet 1062 of the sampling device can be set at any part of the sampling device. Figure 1 2 shows that the gas inlet 1062 is disposed at the lower rear portion of the sampling device 106 , however, this does not limit the gas inlet 1062 to be disposed only at this portion of the sampling device 106 .

[0045] The second two-position three-way valve 105B is configured such that, in the state of cleaning the sampling device, the gas discharged from the ion mobility spectrometer 101 is directly sent to the sampling device 106 instead of the ion mobility spectrometer 101 through the second two-position three-way valve 105B after being filtered / purified, and passes through the sampling device 106 to clean the sampling device 106, that is, the gas enters the second two-position three-way valve from the inlet 105B2 of the second two-position three-way valve, and leaves the second two-position three-way valve 105B from the first outlet 105B1 of the second two-position three-way valve. It is advantageous that the second two-position three-way valve 105B is directly connected to the sampling device 106 (gas inlet 1062 thereof), which can reduce the influence of temperature changes, environmental pressure changes and micro-injection on the ion mobility spectrometer 101.

[0046] The second two-position three-way valve 105B is also configured as follows: in the first gas internal circulation state, the fluid connection between the ion mobility spectrometer 101 and the sampling device 106 is disconnected, and part of the gas discharged from the ion mobility spectrometer 101 is sent back to the ion mobility spectrometer 101 through the second two-position three-way valve 105B after filtering / purification, that is, the gas enters the second two-position three-way valve 105B from the inlet 105B2 of the second two-position three-way valve 105B, and leaves the second two-position three-way valve 105B from the second outlet 105B3 of the second two-position three-way valve 105B, and the gas is not sent to the sampling device 106, such as the gas inlet 1062 of the sampling device 106, but is sent to the ion mobility spectrometer 101.

[0047] In one embodiment, it can be considered that the circulating gas circuit includes a first internal circulating sub-gas circuit, and the gas exhausted from the ion mobility spectrometer 101 is sent back to the ion mobility spectrometer 101 via the first internal circulating sub-gas circuit; the first internal circulating sub-gas circuit is: after the gas is discharged from the ion mobility spectrometer 101, it enters from the inlet 105B2 of the second two-position three-way valve 105B, is discharged from the second outlet 105B3 of the second two-position three-way valve 105B, is sent to the first two-position three-way valve 105A (i.e., the second inlet 105A2 of the first two-dimensional three-way valve), and is then sent back to the ion mobility spectrometer.

[0048] In one embodiment, the circulating gas circuit includes a filter 104, which is configured to allow the gas exhausted from the ion mobility spectrometer 101 to at least pass through the filter 104 in the circulating gas circuit to filter / purify the gas. In one embodiment, the circulating gas circuit includes a first buffer tank 102A having a certain gas volume, which is configured to be in fluid communication with the ion mobility spectrometer 101 to receive the gas exhausted from the ion mobility spectrometer 101, and allow at least a portion of the gas exhausted from the first buffer tank 102A to be fed into the ion mobility spectrometer 101.

[0049] For example, in one embodiment, the gas discharged from the first buffer tank 102A may first pass through the filter 104, and the gas filtered / purified by the filter 104 may be sent to the subsequent components, such as the ion mobility spectrometer 101; or the gas may be sent to the ion mobility spectrometer 101 after passing through other components, thereby realizing the circulation and use of the gas. The filter 104 may be any suitable filter 104 in the prior art, which is not limited here. It is advantageous to arrange the filter 104 downstream of the gas flow of the first buffer tank 102A, and the operating vibration of the filter 104 will not affect the detection of the ion mobility spectrometer 101.

[0050] In one embodiment, a pump 103 is provided, for example, the pump 103 is in fluid communication with the first buffer tank 102A, the operation of the pump 103 can drive the gas to be discharged from the first buffer tank 102A, and the gas discharged by the pump 103 can be passed into the filter 104. In this way, the operating vibration of the pump 103 will not affect the detection accuracy of the ion mobility spectrometer 101.

[0051] In one embodiment, the circulating gas circuit includes a second buffer tank 102B with a certain gas volume, which is configured to receive gas from the first buffer tank 102A and allow the gas discharged from the second buffer tank 102B to be sent to the ion migration spectrometer 101. In one embodiment, the pump 103 can be arranged between the first buffer tank 102A and the second buffer tank 102B. This is advantageous, and the vibration generated by the pump 103 due to operation will be absorbed by the first buffer tank 102A and the second buffer tank 102B, and the vibration generated by the pump 103 will not affect the measurement of the ion migration spectrometer 101, nor will it be transmitted to the sampling device 106 to affect the sampling operation. The pump 103 can be a diaphragm pump 103 but is not limited to the diaphragm pump 103. In combination with the pump 103 and the first two-position three-way valve and the second two-position three-way valve, a positive pressure can be formed between the second buffer tank 102B and the second two-position three-way solenoid valve 105B, and the residual sample in the sampling head can be cleaned. In this cleaning mode, the external environment will not interfere with the gas inside the system.

[0052] In one embodiment, the filter 104 may be disposed between the first buffer tank 102A and the second buffer tank 102B. This is advantageous because the vibration generated by the filter 104 during operation will be absorbed by the first buffer tank 102A and the second buffer tank 102B, and the vibration generated by the filter 104 will not affect the measurement of the ion mobility spectrometer 101.

[0053] The first buffer tank 102A and / or the second buffer tank 102B may include a buffer membrane. For example, a retractable buffer membrane is provided on at least a portion of at least one side of the first buffer tank 102A and / or the second buffer tank 102B for sealing to enhance the buffering effect, such as a flexible buffer membrane, such as a latex buffer membrane.

[0054] In one embodiment, the second buffer tank 102B can receive gas from the first buffer tank 102A, and part of the gas discharged from the second buffer tank 102B is sent to the ion mobility spectrometer 101, and the other part is sent to the inlet of the second two-position three-way valve. Through such configuration, the gas discharged from the ion mobility spectrometer 101 is directly sent back to the ion mobility spectrometer 101 after being filtered by the filter 104, without passing through the second two-position three-way valve 105B and the first two-position three-way valve 105A, thereby realizing local circulation of the gas; another part of the gas discharged from the second buffer tank 102B is first sent to the sampling device 106, and then sent to the ion mobility spectrometer 101 from the sampling device 106, that is, the gas entering the second two-position three-way valve is discharged from the first outlet 105B1 of the second two-position three-way valve 105B and is first sent to the sampling device 106, or the gas entering the second two-position three-way valve 105B is discharged from the second outlet 105B3 of the second two-position three-way valve 105B and is sent to the ion mobility spectrometer 101. The percentage of the gas sent to the ion mobility spectrometer 101 and the gas sent to the second two-position three-way valve 105B can be allocated to realize the adjustment of sampling.

[0055] In other embodiments of the present disclosure, the second buffer tank 102B may not be included, that is, after the gas is discharged from the ion mobility spectrometer, it is sent to the first buffer tank 102A and then pumped out by the pump 103. The pump 103 sends the gas into the filter 104. Part of the gas leaving the filter 104 is sent back to the ion mobility spectrometer, and the other part is sent to the second two-position three-way valve 105B.

[0056] In one embodiment, the ion mobility spectrometer 101 further includes a first outlet 1014 and / or a second outlet 1015 configured to discharge the gas in the ion mobility spectrometer 101; and a first circulation inlet 1012 and / or a second circulation inlet 1013 configured to circulate the gas into the ion mobility spectrometer 101; and

[0057] The circulating gas circuit includes a second inner circulating sub-gas circuit, and is configured such that the gas discharged from the first outlet 1014 and / or the second outlet 1015 of the ion mobility spectrometer 101 at least passes through the filter 104, and then a portion of the gas is sent into the ion mobility spectrometer 101 through the first circulating inlet 1012 and / or the second circulating inlet 1013 of the ion mobility spectrometer 101. In this embodiment, the gas sent into the ion mobility spectrometer through the first circulating inlet 1012 and / or the second circulating inlet 1013 is only used for gas circulation, and the gas is not sent into the reaction area or ionization area of ​​the ion mobility spectrometer.

[0058] The present disclosure provides an ion mobility spectrometer solution based on pulse sampling. Pulse sampling is achieved by switching the solenoid valve, and the minimum sampling volume can reach tens of microliters, so that the ion mobility spectrometer using this pulse sampling direct injection working mode can also maintain a high degree of cleanliness in a harsh experimental environment and be free from interference from the external environment and work stably for a long time. Compared with traditional membrane injection and other measuring equipment, the sensitivity is greatly improved. In addition, the pipeline, valve and sampling device are back-blown and cleaned by the positive pressure formed, and there is no need to draw filtered clean air from the environment, ensuring that the gas inside the system is not disturbed by the external environment. On the one hand, additional filtering accessories can be eliminated, so that the ion mobility spectrometer can be used in a more harsh external environment, which can greatly improve the working efficiency of ion migration.

[0059] Although some embodiments of the present general patent concept have been shown and described, it will be appreciated by those skilled in the art that changes may be made to these embodiments without departing from the principles and spirit of the present general patent concept, the scope of which is defined by the claims and their equivalents.

Claims

1. An ion mobility spectrometer device based on pulse sampling, comprising: an ion mobility spectrometer configured to detect the sample; A sampling device configured to collect a sample and output a mixed gas containing the sample; as well as a circulating gas circuit configured to connect the sampling device with the ion mobility spectrometer fluid so as to introduce the mixed gas containing the sample output by the sampling device into the ion mobility spectrometer, and to be able to return at least part of the gas discharged by the ion mobility spectrometer to the ion mobility spectrometer and / or the sampling device; wherein the circulating gas circuit is configured to allow the ion mobility spectrometer device to switch between a sampling and injection state and a first gas internal circulation state, Wherein, in the sampling and injection state, the sampling device collects a sample and sends the sample into the ion mobility spectrometer as a mixed gas containing the sample through gas for detection, and a part of the gas exhausted from the ion mobility spectrometer is sent back to the sampling device after filtering / purification to form a mixed gas containing the sample with the sample so as to transport the sample; and In the first gas internal circulation state, the fluid connection between the sampling device and the ion mobility spectrometer is disconnected, and the gas exhausted by the ion mobility spectrometer is sent back to the ion mobility spectrometer after being filtered / purified; The ion mobility spectrometer device further comprises a first two-position three-way valve (105A), which is fluidically connected between the sampling device in the circulation gas circuit and the ion mobility spectrometer and is configured to: In the sampling and injection state, the sampling device and the ion mobility spectrometer are allowed to be fluidically connected, gas enters the first two-position three-way valve from the first inlet of the first two-position three-way valve, leaves the first two-position three-way valve from the outlet of the first two-position three-way valve, and is sent to the ion mobility spectrometer through the first inlet of the ion mobility spectrometer; and in the first gas internal circulation state, the fluid connection between the sampling device and the ion mobility spectrometer is disconnected, and the gas discharged from the ion mobility spectrometer is allowed to be sent back to the ion mobility spectrometer through the second inlet of the first two-position three-way valve (105A) after being filtered / purified; The circulating gas circuit is configured to allow the ion mobility spectrometer to switch between a sampling and injection state, a first gas internal circulation state, and a sampling device cleaning state; in the sampling device cleaning state, the gas exhausted from the ion mobility spectrometer is sent to the sampling device after being filtered / purified, and after passing through the sampling device, is exhausted from the sampling device in the reverse direction of the sampling device; The ion mobility spectrometer device further comprises a second two-position three-way valve (105B), which is fluidically connected between the ion mobility spectrometer and the sampling device in the circulation gas circuit and is directly connected to the sampling device, and the second two-position three-way valve (105B) is configured as follows: In the sampling and injection state, the gas discharged from the ion mobility spectrometer is directly sent to the sampling device through the second two-position three-way valve (105B) after being filtered / purified, and the gas is mixed with the sample to form a mixed gas containing the sample and sent to the ion mobility spectrometer, and a part of the gas discharged from the ion mobility spectrometer is sent back to the sampling device through the second two-position three-way valve (105B) as a carrier gas after being filtered / purified; In the state of cleaning the sampling device, the gas exhausted from the ion mobility spectrometer is sent to the sampling device instead of the ion mobility spectrometer through the first outlet of the second two-position three-way valve (105B) after being filtered / purified, and passes through the sampling device so as to clean the sampling device; and In the first gas internal circulation state, the fluid connection between the ion mobility spectrometer and the sampling device is disconnected, and part of the gas exhausted from the ion mobility spectrometer is sent back to the ion mobility spectrometer through the second outlet of the second two-position three-way valve (105B) after filtering / purification, and the gas does not pass through the sampling device.

2. According to the pulse sampling based ion mobility spectrometer device according to claim 1, wherein the circulating gas circuit comprises a first internal circulating sub-gas circuit, and the gas exhausted by the ion mobility spectrometer is sent back to the ion mobility spectrometer via the first internal circulating sub-gas circuit; the first internal circulating sub-gas circuit is: after being discharged from the ion mobility spectrometer, the gas enters from the inlet of the second two-position three-way valve, is discharged from the second outlet of the second two-position three-way valve, is sent to the first two-position three-way valve, and is then sent back to the ion mobility spectrometer.

3. An ion mobility spectrometer device based on pulse sampling according to claim 2, wherein the circulating gas circuit includes a first buffer tank having a certain gas volume, configured to be fluidically connected to the ion mobility spectrometer so as to receive the gas exhausted from the ion mobility spectrometer and allow the gas exhausted from the first buffer tank to be fed into the ion mobility spectrometer. 4 . The pulse sampling-based ion mobility spectrometer device according to claim 3 , wherein the circulation gas circuit comprises a filter, and is configured to allow the gas exhausted from the ion mobility spectrometer to at least pass through the filter in the circulation gas circuit to filter / purify the gas. 5 . The pulse sampling-based ion mobility spectrometer apparatus according to claim 3 , wherein the circulation gas circuit comprises a pump configured to drive gas in the circulation gas circuit to leave the ion mobility spectrometer and flow in the circulation gas circuit.

6. The pulse sampling-based ion mobility spectrometer device according to claim 4, wherein the circulating gas circuit comprises a second buffer tank (102B) having a certain gas volume, configured to receive gas from the first buffer tank and allow at least a portion of the gas exhausted from the second buffer tank to be fed into the ion mobility spectrometer.

7. The pulse sampling-based ion mobility spectrometer device according to claim 6, wherein the second buffer tank is capable of receiving gas from the first buffer tank, and a portion of the gas discharged from the second buffer tank is fed into the ion mobility spectrometer, and another portion is fed into the inlet of the second two-position three-way valve.

8. The pulse sampling-based ion mobility spectrometer device according to claim 7, wherein the ion mobility spectrometer further comprises a first outlet and / or a second outlet configured to discharge the gas in the ion mobility spectrometer; and a first circulation inlet and / or a second circulation inlet configured to circulate the gas into the ion mobility spectrometer; and The circulating gas circuit includes a second inner circulating sub-gas circuit, which is configured such that the gas discharged from the first outlet and / or the second outlet of the ion mobility spectrometer at least passes through the filter, and then a portion of the gas is sent into the ion mobility spectrometer through the first circulating inlet and / or the second circulating inlet of the ion mobility spectrometer.

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