A liquid quantitative transfer device based on centrifugal force

Abstract

The present invention relates to a liquid quantitative transfer device based on centrifugal force, which comprises a measuring chamber, an overflow chamber connected to the measuring chamber through a first fluid channel, a fluid outlet arranged at the outer end of the measuring chamber, a control valve connected to the fluid outlet, and a second channel for connecting the measuring chamber or the overflow chamber with the atmosphere. When the control valve is triggered, the liquid in the measuring chamber is discharged through the fluid outlet. An inlet channel and an overflow outlet are arranged on the top of the measuring chamber, and an overflow inlet is arranged on the overflow chamber. The two ends of the first fluid channel are respectively connected to the overflow outlet and the overflow inlet. Under the action of centrifugal force, the present invention can fill the measuring chamber with liquid entering from the inlet channel, and the excess liquid enters the overflow chamber. Then the control valve is opened to discharge all the liquid in the measuring chamber, while the liquid in the overflow chamber will not be discharged, so that the function of quantitatively transferring the liquid of the entire measuring chamber volume can be realized.

Description

Technical Field

[0001] The invention relates to a liquid quantitative transfer device based on centrifugal force. Background Art

[0002] In the fields of medical testing and biochemical testing, it is often necessary to perform a series of testing processes on fluid samples. In modern medicine, a reagent disc has been designed that can perform multiple tests on samples at one time on a disc structure, such as the Chinese patent application number 201810450478.2. In these application fields, one of the most important operations is the precise measurement of liquids and the transfer of a certain amount of liquid to a specific area for biochemical reactions. Therefore, it is very important to design a structure that can achieve quantitative transfer of liquids. Summary of the invention

[0003] The technical problem to be solved by the present invention is to provide a liquid quantitative transfer device based on centrifugal force, by which the liquid quantitative transfer under specific conditions can be achieved.

[0004] The technical solution adopted by the present invention is: a liquid quantitative transfer device based on centrifugal force, which includes a measuring chamber, an overflow chamber connected to the measuring chamber through a first fluid channel, a fluid outlet arranged at the outer end of the measuring chamber, a second fluid channel connected to the fluid outlet, and a second channel for connecting the measuring chamber or the overflow chamber with the atmosphere, a control valve is arranged on the second fluid channel, when the control valve is triggered, the liquid in the measuring chamber is discharged through the fluid outlet, an inlet channel and an overflow outlet are arranged on the top of the measuring chamber, and an overflow inlet is arranged on the overflow chamber, and the two ends of the first fluid channel are respectively connected to the overflow outlet and the overflow inlet.

[0005] Furthermore, the second channel is arranged on the overflow chamber.

[0006] Furthermore, the control valve is a capillary passive valve.

[0007] Furthermore, the second fluid channel is in the form of a siphon pipe, and one end of the siphon pipe is connected to the fluid outlet.

[0008] Furthermore, the portion of the siphon pipe closest to the axis is radially outward relative to the overflow outlet or the first fluid channel or the overflow inlet.

[0009] Furthermore, the control valve is a second siphon pipe, and the portion of the second siphon pipe closest to the axis is radially inward relative to the overflow outlet or the first fluid channel or the overflow inlet.

[0010] Furthermore, the second siphon pipe is made of hydrophilic material or is treated with hydrophilicity.

[0011] Furthermore, the second channel is arranged at the top of the measuring chamber, the control valve is a third siphon pipe, and the portion of the third siphon pipe closest to the axis is radially inward relative to the overflow outlet or the first fluid channel or the overflow inlet.

[0012] Furthermore, the measuring chamber, the first fluid channel and the overflow chamber are all arranged on a reagent disk which can be rotated by a driving device.

[0013] Furthermore, the control valve uses a hydrophobic material or performs a hydrophobic treatment for the second fluid channel.

[0014] The positive effect of the present invention is that under the action of centrifugal force, the present invention can fill the measuring chamber with liquid entering from the inlet channel, and the excess liquid enters the overflow chamber, and then the valve is controlled to open to discharge all the liquid in the measuring chamber, while the liquid in the overflow chamber will not be discharged, so that the function of quantitative transfer of the liquid in the entire measuring chamber volume can be realized. At the same time, due to the structure of the present invention, the function of liquid transportation can be realized without or only with a small compressible medium being compressed in the overflow chamber, and the volume of the overflow chamber is small. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a schematic diagram of the structure of Embodiment 1 of the present invention;

[0016] Figure 2 This is a schematic diagram of the structure of Embodiment 2 of the present invention;

[0017] Figure 3 This is a schematic diagram of the structure of Embodiment 3 of the present invention;

[0018] Figure 4 This is a structural schematic diagram of Example 4 of the present invention. DETAILED DESCRIPTION

[0019] First, it should be noted that in the following description, the bottom refers to the side away from the rotation center of the reagent disk 9, and the top refers to the side close to the rotation center of the reagent disk 9. Moreover, radially inward and radially outward are both relative to the rotation center of the reagent disk 9.

[0020] Embodiment 1: As attached Figure 1As shown, the present invention includes a rotatable reagent disk 9, a measuring chamber 1 arranged on the reagent disk 9, an overflow chamber 2 connected to the measuring chamber 1 through a first fluid channel 3, a fluid outlet 6 arranged at the bottom of the measuring chamber 1, a second fluid channel 5 connected to the fluid outlet 6, and a second channel 7 for connecting the overflow chamber 2 with the atmosphere. A control valve is arranged on the second fluid channel 5, and the control valve is a capillary passive valve. When the control valve is triggered, the liquid in the measuring chamber 1 is discharged through the fluid outlet 6. An inlet channel 4 and an overflow outlet 10 are arranged at the top of the measuring chamber 1, and an overflow inlet 11 is arranged at the top of the overflow chamber 1. The two ends of the first fluid channel 3 are respectively connected to the overflow outlet 10 and the overflow inlet 11.

[0021] Preferably, the reagent disk 9 is circular and rotates with the center of the circle as the axis, but other shapes may be used. As for the structure driving the reagent disk 9 to rotate, a conventional centrifugal rotor or CD / DVD drive with adjustable speed may be used, or other structures may be used, as long as the reagent disk 9 can be rotated so that the liquid on the reagent disk 9 generates centrifugal force.

[0022] When the reagent disk 9 rotates, the liquid in the inlet channel 4 enters the measuring chamber 1 under the action of centrifugation until the measuring chamber 1 is completely filled, and part of the liquid enters the overflow chamber 2 through the first fluid channel 3. At this time, the liquid in the overflow chamber 2 is located at the bottom of the overflow chamber 2 under the action of centrifugation and is separated from the liquid in the measuring chamber 50. The amount of liquid entering from the inlet channel 4 is controlled so that the liquid level in the overflow chamber 2 is lower than the connection between the second channel 7 and the overflow chamber 2, so that no compressible medium is compressed in the overflow chamber 2. In the process of the measuring chamber 1 being filled, due to the action of the capillary passive valve, a capillary force in the opposite direction to the centrifugal force is generated in the second fluid channel 5, and the capillary force is greater than the centrifugal force, preventing the liquid from being discharged through the second fluid channel 5, so that the liquid entering the measuring chamber 1 will be temporarily stored in the measuring chamber 1. Then, the reagent disk 9 is driven to increase its rotation speed. When the centrifugal force of the liquid in the second fluid channel 5 is greater than the capillary force, all the liquid temporarily stored in the measuring chamber 1 will be transported out through the second fluid channel 5, thereby achieving the quantification of the liquid. The acceleration time of the reagent disk 9 can be adjusted to discharge the liquid at a specific time point.

[0023] The following structure can be used for the capillary passive valve, which includes at least one part, so that the internal size of the second fluid channel 5 changes suddenly (not shown in the figure), for example, the internal size of a certain part of the second fluid channel 5 suddenly becomes larger. Alternatively, the second fluid channel 5 can be treated with hydrophobicity or made of hydrophobic material to form a valve with similar functions.

[0024] Embodiment 2: As attached Figure 2As shown, on the basis of Example 1, other structures are kept unchanged and the structure of the second fluid channel 5 is changed. The second fluid channel 5 adopts the structure of a siphon pipe 8, one end of which is connected to the fluid outlet 6, and its curved part is located on the side close to the rotation center of the reagent disk 9. The part of the siphon pipe 8 closest to the axis is radially outward relative to the overflow outlet 10 or the first fluid channel 3 or the overflow inlet 11 (that is, the minimum distance between the siphon pipe 8 and the axis of rotation of the reagent disk is greater than the distance between the overflow outlet 10 or the first fluid channel 3 or the overflow inlet 11 and the axis of rotation of the reagent disk), that is, the distance between the overflow outlet 10 and the axis is less than the minimum distance between the siphon pipe 8 and the axis of rotation, and the first fluid channel 3 and the overflow inlet 11 are the same. The control valve located in the second fluid channel can be arranged in the relatively inner part of the siphon pipe 8. When the liquid flowing out of the fluid outlet 6 enters the siphon pipe 8, it first needs to flow along the siphon pipe 8 to the side toward the rotation center until it hits the control valve arranged on the siphon pipe 8. This reduces the difference between the top of the liquid in the entire structure and the liquid level in the siphon pipe 8, further reducing the centrifugal force. This makes it easier to implement the valve on the siphon pipe.

[0025] Embodiment 3: As attached Figure 3 As shown, on the basis of Example 1, other structures remain unchanged, and the control valve is changed into the form of a second siphon pipe 12, one end of which is connected to the second fluid channel 5. The part of the second siphon pipe 12 closest to the axis is radially inward relative to the overflow outlet 10 or the first fluid channel 3 or the overflow inlet 11, that is, the minimum distance between the second siphon pipe 12 and the rotation axis is less than the distance between the overflow outlet 10 and the rotation axis, and the same is true for the first fluid channel 3 and the overflow inlet 11. The second siphon pipe 12 is made of hydrophilic material or is treated to be hydrophilic.

[0026] At the beginning, the reagent disk 9 is at a high speed, and the speed is generally greater than 50 rpm. Under the rotation of the reagent disk 9, the liquid enters the measuring chamber 1 until part of the liquid enters the overflow chamber 2. At this time, the liquid in the overflow chamber 2 is located at the bottom of the overflow chamber 2 under the centrifugal action and is separated from the liquid in the measuring chamber 50. The amount of liquid entering the inlet channel 4 is controlled so that the liquid level in the overflow chamber 2 is lower than the connection between the second channel 7 and the overflow chamber 2, so that no compressible medium in the overflow chamber 2 is compressed. At this time, the liquid flowing into the measuring chamber is temporarily stored in the measuring chamber 1, and the centrifugal force is greater than the capillary force of the second siphon pipe 12 at this time, and the liquid will not flow out of the second siphon pipe 12. When the speed of the reagent disk 9 decreases, the centrifugal force decreases until the capillary force is greater than the centrifugal force. Due to the capillary force, the liquid climbs over the part of the second siphon pipe 12 closest to the rotation axis and continues to flow in the direction away from the rotation axis. Next, due to the siphon effect, the liquid in the measuring chamber 1 is transported out.

[0027] When the liquid level in the overflow chamber 2 is higher than the second channel 7, part of the compressible medium (gas in this embodiment) in the overflow chamber 2 is compressed. When the rotation speed of the reagent disk 9 decreases, the compressed medium in the overflow chamber 2 expands, thereby transporting the liquid in the measuring chamber 1 to the second siphon pipe 12, until the liquid passes through the part of the second siphon pipe 12 closest to the rotation center, and then due to the siphon effect, all the liquid in the measuring chamber 1 is transported out through the second siphon pipe. It can be seen from this that when more liquid is added from the inlet channel 4, so that the liquid level in the overflow chamber 2 is located above the connection between the second channel 7 and the overflow chamber 2, the second siphon pipe 12 does not need to be hydrophilic.

[0028] Embodiment 4: As attached Figure 4 As shown, based on Example 3, the second channel 7 is connected to the top of the measuring chamber 1, the inner diameter of the second channel 7 is smaller, and the third siphon pipe 13 without hydrophilic treatment is connected to the second fluid channel 5, and other structures remain unchanged.

[0029] With this structure, when the liquid enters the overflow chamber 2, part of the compressible medium in the overflow chamber 2 is compressed. When the rotation speed of the reagent disk 9 decreases, the compressed compressible medium in the overflow chamber 2 expands, thereby transporting the liquid in the measuring chamber 1 to the third siphon pipe 13, until the liquid passes through the part of the third siphon pipe 13 closest to the rotation center. Then, due to the siphon effect, all the liquid in the measuring chamber 1 is transported out through the third siphon pipe 13. In this process, since the inner diameter of the second channel 7 is small, the speed of exhausting gas from the second channel 7 is also slow, and the gas expansion mainly acts to press the liquid in the measuring chamber 2 into the third siphon pipe 13. With the structure of this embodiment, the compressed gas in the overflow chamber 2 only needs to press the liquid in the measuring chamber 1 through the part of the third siphon pipe 13 closest to the rotation axis, and the requirement for the amount of compressed gas is low, so that the overflow chamber 2 can maintain a small volume, thereby reducing the area of ​​the overflow chamber 2 and improving the overall utilization rate of the reagent disk 9.

[0030] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features thereof may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A liquid quantitative transfer device based on centrifugal force, characterized in that The invention comprises a measuring chamber (1), an overflow chamber (2) connected to the measuring chamber (1) through a first fluid channel (3), a fluid outlet (6) arranged at the outer end of the measuring chamber (1), a second fluid channel (5) connected to the fluid outlet (6), and a second channel (7) for connecting the overflow chamber (2) with the atmosphere, wherein the second channel (7) is arranged on the overflow chamber (2), and the connection between the second channel (7) and the overflow chamber (2) is located in the middle of the side wall of the overflow chamber (2); a control valve is arranged on the second fluid channel (5), and when the control valve is triggered, the liquid in the measuring chamber (1) is discharged through the fluid outlet (6); an inlet channel (4) and an overflow outlet (10) are arranged on the top of the measuring chamber (1), and an overflow inlet (11) is arranged on the overflow chamber (2); the two ends of the first fluid channel (3) are respectively connected to the overflow outlet (10) and the overflow inlet (11); the portion of the measuring chamber (1) closest to the axis is radially outward relative to the position of the overflow chamber (2).

2. The liquid quantitative transfer device based on centrifugal force according to claim 1, characterized in that: The control valve is a capillary passive valve.

3. The device for quantitatively transferring liquid based on centrifugal force according to claim 1, characterized in that The second fluid channel (5) is in the form of a siphon pipe (8), one end of which is in communication with the fluid outlet (6).

4. The device for quantitatively transferring liquid based on centrifugal force according to claim 3, characterized in that The portion of the siphon pipe (8) closest to the axis is located radially outward relative to the overflow outlet (10) or the first fluid channel (3) or the overflow inlet (11).

5. The device for quantitatively transferring liquid based on centrifugal force according to claim 1, characterized in that The control valve is a second siphon pipe (12), and the portion of the second siphon pipe (12) closest to the axis is located radially inward relative to the overflow outlet (10) or the first fluid channel (3) or the overflow inlet (11).

6. The device for quantitatively transferring liquid based on centrifugal force according to claim 5, characterized in that The second siphon pipe (12) is made of hydrophilic material or is treated to be hydrophilic.

7. The device for quantitatively transferring liquid based on centrifugal force according to claim 1, characterized in that The measuring chamber (1), the first fluid channel (3) and the overflow chamber (2) are all arranged on a reagent disk (9) which can be rotated by a driving device.

8. The device for quantitatively transferring liquid based on centrifugal force according to claim 1, characterized in that The control valve is a second fluid channel (5) made of a hydrophobic material or subjected to a hydrophobic treatment.

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