A detection device for detecting an analyte in a sample

Abstract

The present invention provides a detection device for detecting an analyte in a test sample. The device includes a first chamber and a second chamber. The first chamber is used to collect a liquid sample and perform an initial detection, and the second chamber is used to collect the liquid sample for a secondary confirmation detection. The first chamber and the second chamber of the device are detachably combined. When a secondary confirmation detection is required, the second chamber can be separated from the first chamber and then sent to a confirmation detection institution for confirmation detection. It can avoid the possible contamination of the sample caused by the contact between the test reagent strip of the traditional device and the liquid sample; effectively reduce the space required for storing the liquid sample, and greatly reduce the risk of leakage of the liquid sample during transportation.

Description

[0001] This application claims the priority of a prior Chinese application with the application number 201810150485.0 and the filing date of February 13, 2018. Technical Field

[0002] The present invention relates to a detection device for analyzing substances in a test sample, particularly a device for collecting and detecting analytes in a liquid sample in the field of rapid diagnosis, such as a urine collection and detection device. Background Art

[0003] Currently, detection devices for determining whether an analyte is present in a test sample are widely used in hospitals or at home. These detection devices for rapid diagnosis include one or more test strips, such as early pregnancy detection. Such rapid diagnostic detection devices are very convenient and can obtain test results on the test strip in one minute or at most about ten minutes.

[0004] Although, in traditional technologies, it is possible to isolate the tested sample from the collected sample, the cost is high and it is not easy to operate. For example, the piston urine cup described in US Patent No. 7,300,633. When the piston is pushed forward, the liquid sample in the collection chamber, such as urine, is transferred from the collection chamber to the detection chamber. There is a test element in the detection chamber for analyzing the analyte in the sample, and the liquid sample in the collection chamber is isolated by the piston, so that the samples in the two places will not be confused and can be used for subsequent confirmation testing. Although this can isolate the tested sample from the collected sample, such a piston urine cup has a high cost and is not easy to operate. After all, pushing the piston requires a relatively large amount of force because the piston needs to achieve sample transfer and must have a liquid sealing effect with the wall of the piston. To achieve the sealing effect, the piston and the piston chamber need to be closely combined. In addition, when performing secondary testing, the entire device must be transported to a testing institution.

[0005] For another example, US Patent No. 8,992,855 describes a device for collecting a liquid sample. The device includes a piston structure integrated with and moving with a lid. Although the tested sample can be separated from the collected sample, after the tested sample enters the detection chamber, it needs to overcome a large pressure to enter, and the dimensions of the lid and the cup mouth need to be precisely designed so that the piston integrated with the lid can accurately insert into the separation chamber.

[0006] In addition, after the initial tests of these traditional collection and detection devices are completed, if subsequent confirmation tests are required, the entire collection and detection device needs to be transported to a confirmation testing agency for further confirmation testing. This brings many problems, at least the following problems: First, most current liquid collection and detection devices only have a preliminary detection chamber. When subsequent confirmation tests are needed, only the entire device containing urine and the test strip can be sent to the confirmation testing agency for testing. In this way, the sample in the urine cup may be contaminated by the test reagent. Second, when sending the entire device to the confirmation testing agency, due to the large cup mouth, there is a risk of liquid leakage during transportation. This requires more costs to make the device have a better sealing effect to minimize the risk of leakage. Third, the confirmation testing agency needs a huge low-temperature warehouse to store the entire detection device to prevent the liquid sample from deteriorating, in preparation for possible further confirmation tests in the future. This causes a significant increase in the costs of the confirmation testing agency (which can be called the secondary testing agency).

[0007] In view of the above technical problems, it is necessary to improve them and provide an alternative way to solve the deficiencies of the existing traditional technologies. Summary of the Invention

[0008] In view of the above situation, to overcome the defects of the existing technologies, the purpose of the present invention is to provide a detection device that can separate the initial detection sample and the confirmation detection sample (secondary detection). After collecting the liquid sample, before or after the detection, the initial detection sample and the confirmation detection sample can enter two cavities, such as the first cavity and the second cavity. Then, after or before the initial detection is completed, the second cavity can be separated from the initial collection cavity (the first cavity), thus realizing the detachable separation of the second cavity and the cavity for initially collecting the sample. The second cavity separated from the initial collection cavity can be used for subsequent second detection or subsequent confirmation detection. Thus, it is possible to effectively separate the initial detection sample and the subsequent possible confirmation detection sample (second detection), and finally achieve one-time collection and at least two detections.

[0009] It can also be considered that when the collection device includes two cavities, these two cavities receive the same liquid sample, such as urine, simultaneously or in sequence. One of the cavities, such as the first cavity, is used to collect a part of the liquid sample, and the other cavity, such as the second cavity, is used to collect another part of the liquid sample. When the collection is completed or during the collection, the liquid in the first cavity can be used to contact the test element to complete the first test, and the second cavity can be separated from the first cavity for secondary detection.

[0010] In a first aspect of the present invention, the present invention provides a device for collecting a liquid sample, the device comprising: a first chamber for collecting the liquid sample; and a second chamber for collecting a sample for confirming the detection of the liquid sample; wherein the first chamber and the second chamber are detachably combined, assembled or connected.

[0011] In some preferred embodiments, before the second chamber is separated from the first chamber, the first chamber and the second chamber are in a state of liquid communication; or, when the first chamber and the second chamber are combined together, the first chamber and the second chamber are in a state of liquid flow. In this way, whether the first chamber or the second chamber is used to collect or receive the liquid sample, the liquid can flow between the two chambers, and this flow can be an active flow or a passive flow.

[0012] In some preferred embodiments, the active flow means that the liquid can flow naturally from the first chamber to the second chamber or from the second chamber to the first chamber without external force. In some preferred embodiments, the passive flow is caused by an external force to make the liquid flow from the first chamber to the second chamber or from the second chamber to the first chamber. Here, the external force can refer to negative pressure, pressure, or compressing the liquid to make the liquid flow.

[0013] In some preferred embodiments, after the second chamber is separated from the first chamber or before it is about to be separated, the first chamber and the second chamber are not in liquid communication, so that the liquid does not flow between the two chambers. In some preferred embodiments, before the second chamber is separated from the first chamber or before it is about to be separated, the first chamber and the second chamber are not in liquid communication. Or, in some preferred embodiments, at the same time as the second chamber is separated from the first chamber, the first chamber and the second chamber are not in liquid communication. In some preferred embodiments, after the second chamber is separated from the first chamber, the second chamber stores the liquid sample from the first chamber. In some preferred embodiments, when the first chamber is collecting the liquid sample or after it has finished collecting, the second chamber also collects the liquid sample from the first chamber. In some preferred embodiments, while the first chamber is collecting the liquid sample, the second chamber also collects the liquid sample from the first chamber.

[0014] In some additional embodiments, the first chamber and the second chamber can be detachably combined together by a combination position, and separated by the combination position. Here, the combination means that the two chambers are separated before use, assembled together during use, and separated after use. Alternatively, the first chamber and the second chamber can be directly combined together or indirectly combined together through a certain structure. The combination position can be the place where the first chamber and the second chamber are in physical contact. Therefore, in another aspect of the present invention, the first chamber and the second chamber are initially assembled together. After collecting the liquid sample, the second chamber is separated from the first chamber. The first chamber can be used for the first detection, and the second chamber can be used for the secondary detection or confirmation detection. In an alternative manner, the first chamber and the second chamber are initially separated and not assembled together. After collecting the liquid sample, the second chamber is combined with the first chamber, so that part of the liquid can communicate or flow between the first chamber and the second chamber. When secondary detection is required, the two chambers are separated. The first chamber can be used for the first detection, and the second chamber can be used for the secondary detection or confirmation detection.

[0015] In a second aspect of the present invention, the present invention provides a device for collecting a liquid sample, the device comprising: a first chamber for collecting the liquid sample; and a second chamber for collecting the liquid sample for confirmation detection; wherein, the first chamber and the second chamber are detachably combined, combined or connected indirectly or directly through a combination position.

[0016] In some preferred ways, the second chamber and the first chamber are in liquid communication through a connection channel. In some preferred ways, before the second chamber is separated from the first chamber, the first chamber and the second chamber are in liquid communication through the connection channel. In some preferred ways, after or simultaneously with the separation of the second chamber from the first chamber, the first chamber and the second chamber are not in liquid communication, and the channel is sealed. In some preferred ways, after the second chamber is separated from the first chamber, the second chamber stores the liquid sample from the first chamber. In some preferred ways, when or after the first chamber collects the liquid sample, the second chamber also collects the liquid sample from the first chamber through the connection channel. In some preferred ways, while the first chamber collects the liquid sample, the second chamber also collects the liquid sample from the first chamber through the connection channel.

[0017] In one of the embodiments of all the foregoing ways, the first chamber includes an opening for collecting a liquid sample, and the liquid sample enters the first chamber through this opening. In some preferred ways, the connecting channel is in liquid communication with the first chamber and the second chamber, and the liquid sample can be exchanged between the first chamber and the second chamber through the connecting channel. In some preferred ways, the liquid sample can flow from the first chamber to the second chamber through this connecting channel. In some preferred ways, the connecting channel has a first opening and a second opening, wherein the first opening is in liquid communication with the first chamber, and the second opening is in liquid communication with the second chamber. In some preferred ways, the connecting channel is located on or inside the first chamber. The second chamber is detachably connected, combined or assembled with the first chamber through the connecting channel. Therefore, the connecting channel can indirectly combine, combine or connect the first chamber and the second chamber in a detachable manner.

[0018] In some preferred ways, the connecting channel includes a structure connecting the first chamber and the second chamber and a structure separating the first chamber and the second chamber, wherein the structure connecting the first and second chambers is the space or pipeline forming the channel. In some other preferred ways, or, the connecting channel has two states of being sealed or unsealed. When in the unsealed state, the liquid can flow from the first chamber to the second chamber. Preferably, when the connecting channel is in the sealed state, the liquid in the first chamber cannot flow into the second chamber through the connecting channel. Therefore, the sealing or unsealing of the connecting channel defines the state of liquid exchange between the first chamber and the second chamber. If the connecting channel is unsealed, liquid can be exchanged between the two chambers. When the connecting channel is sealed, there is no liquid exchange between the two chambers.

[0019] In a third aspect of the present invention, the present invention provides a sealing element that can seal a connection channel and keep the connection channel in a sealed state. In a preferred manner, the connection channel is connected to a first chamber and a second chamber, so that through the sealing of the sealing element, the second chamber and the first chamber are in a state where liquid does not flow. In some preferred manners, the device further includes a sealing element for sealing the connection channel. In some preferred manners, when the sealing element seals the channel, or simultaneously during sealing, or after sealing, it excludes a part of the liquid sample in the second chamber. Preferably, the excluded liquid sample goes into the first chamber. Alternatively, when the sealing element seals the connection channel, a part of the liquid sample (if any) in the connection channel is excluded to a place outside the connection channel, such as the first chamber or other places. In some preferred manners, the sealing element may further include an elastic sealing ring, and the sealing ring makes the sealing element contact the inner wall of the connection channel, so that the sealing element is more sealed. In some other preferred manners, the sealing element is more flexible relative to the connection channel, so that relying on the contact between the two, any deformation or extrusion occurs, so that the sealing element and the inner wall of the connection channel are in close contact, thus achieving a sealing effect. For example, the sealing element is elastic and the connection channel is rigid. When an external force forces the sealing element into the connection channel, the elastic element is squeezed and deformed, thus sealing the connection channel.

[0020] In some other manners, the sealing element and the connection are sealed by means of threads. For example, the sealing element has an external thread, the connection channel has an internal thread, and the sealing element seals the connection channel by means of relative rotation. In some other preferred manners, the sealing element is a structure similar to a cover body and has an internal thread, while the outer edge of the first opening of the connection channel has an external thread, so that the sealing element and the connection channel can play a sealing role.

[0021] In a fourth aspect of the present invention, the device of the present invention may further include a liquid discharging element. Before the sealing element seals the first opening of the connection channel, part of the liquid discharging element enters the second chamber. In some preferred manners, after the sealing element seals the opening of the connection channel, part of the liquid discharging element enters the second chamber. Alternatively, before the sealing element seals the first opening of the connection channel, part of the liquid discharging element enters the second chamber through the connection channel.

[0022] Therefore, in the fourth aspect of the present invention, the device of the present invention provides a liquid discharging element for discharging a part of the liquid in the second chamber to the outside of the second chamber. Preferably, before the sealing element seals the first opening of the connecting channel, a part of the liquid discharging element enters the second chamber. In some preferred embodiments, after the sealing element seals the opening of the connecting channel, a part of the liquid discharging element enters the second chamber. Optionally, the liquid discharging element enters the second chamber through the connecting channel, thereby discharging a part of the liquid to the outside of the second chamber. In some preferred embodiments, the liquid discharging element and the sealing element are integrally formed. In some embodiments, the liquid discharging element enters the liquid connecting channel prior to the sealing element. Preferably, the second chamber is detachably combined, assembled or connected with the first chamber through the second opening of the liquid connecting channel. Alternatively, optionally, the liquid discharging element approaches the first opening of the connecting channel prior to the sealing element, wherein the first opening is in liquid communication with the first chamber. In some preferred embodiments, the sealing element is integrally formed with or detachably combined with the liquid discharging element, or in some embodiments, the sealing element can serve two functions, sealing and liquid discharging simultaneously. Optionally, the liquid discharging element can also serve two functions, discharging liquid while sealing the connecting channel. The difference in names here is only a difference in function, and of course, the two functions can be achieved by one element.

[0023] In the fifth aspect of the present invention, the device of the present invention may further include a liquid drainage channel, and the liquid discharged by the liquid discharging element or the sealing element is discharged to the outside of the connecting channel and / or the second chamber through the liquid drainage channel. The so-called "outside" includes the first chamber or other places, such as the receiving chamber. In some preferred embodiments, a liquid receiving cavity is included in the sealing element, and the liquid sample discharged from the second chamber enters the receiving cavity of the sealing element through the liquid drainage channel. Here, the "receiving chamber" refers to collecting the excess liquid discharged by the liquid discharging element or the sealing element. Therefore, the receiving chamber can be the first chamber or other places, such as the space located in the sealing element or the liquid discharging element. In this way, the discharged liquid enters the receiving chamber through the liquid drainage channel. In some preferred embodiments, the liquid drainage channel has one or more liquid inlet ports for allowing the liquid to enter the receiving chamber through the liquid inlet ports. In some preferred embodiments, the liquid inlet port is located downstream of the first opening of the connecting channel. Alternatively, the liquid drainage channel has one or more liquid inlet ports located on the sealing element, and the liquid inlet port enters the connecting channel prior to the sealing element. In some preferred embodiments, after the sealing element seals the connecting channel, the liquid inlet port of the liquid drainage channel opens in the second chamber. In some preferred embodiments, the receiving chamber is located inside the sealing element. In some preferred embodiments, the liquid inlet port of the liquid drainage channel is located on the wall of the sealing element. In some preferred embodiments, the liquid inlet port of the liquid drainage channel is located at the end of the sealing element.

[0024] In some preferred embodiments, the sealing element and the liquid discharging element are integrally structured, wherein the liquid discharging element enters the connection channel prior to the sealing element. In some preferred embodiments, a part of the liquid discharging element enters the second chamber, and the sealing element seals the connection channel. Preferably, the sealing element is located in the connection channel. In some embodiments, the liquid inlet of the liquid repellent channel is located between the sealing element and the liquid discharging element, or under the sealing element, or on the liquid discharging element. In some embodiments, the liquid inlet of the liquid repellent channel is arranged at the end of the liquid discharging element, or enters the connection channel prior to the liquid discharging element, or enters the second chamber prior to the liquid discharging element.

[0025] In a sixth aspect of the present invention, the present invention provides a first cover for covering an opening of a first chamber for collecting a liquid sample, wherein a sealing element for sealing the connection channel is connected to the cover, or the sealing element and the cover are integrally structured. Thus, when the first cover covers the opening of the first chamber, the sealing element also enters the connection channel to seal the connection channel. In some preferred embodiments, the first cover includes the sealing element. In some preferred embodiments, when the first cover covers the opening of the first chamber, the sealing element connected to the first cover seals the first opening of the connection channel. The process of the first cover covering the opening of the first chamber and the process of the sealing element sealing the first opening of the connection channel are substantially synchronous. Or, when the sealing element and the liquid discharging element are integrally structured, or the first cover is provided with the sealing element and the liquid discharging element, the three components can be integrally structured or detachably combined. Thus, when the cover covers the opening of the first chamber, from the start to the completion of the covering process, it is also the process that the sealing element seals the opening of the connection channel, the liquid discharging element discharges a part of the liquid (if any) in the second chamber, and the redundant discharged liquid enters the receiving chamber through the liquid repellent channel.

[0026] In some preferred embodiments, the central axis of the sealing element on the cover and the central axis of the connection channel are substantially on the same line, so that when the first cover covers the opening of the first chamber, the sealing element can also seal the connection channel. In some preferred embodiments, the sealing element is detachably connected to the cover. In some embodiments, the sealing element is connected to the cover by means of a thread. In some embodiments, the sealing element is connected to the cover by a connecting rod, so that the first chamber has a certain depth. When the cover covers the opening of the first chamber, the sealing element is located at or near the opening of the connection channel. When the cover covers the first chamber, the sealing element connected by the connecting rod enters the connection channel from near the first opening of the connection channel to seal the connection channel.

[0027] It can be understood that the sealing element is connected to one end of the connecting rod, and the other end of the connecting rod is connected to the cover body. The movement of the cover body drives the sealing element to move synchronously. For example, the rotation of the cover body drives the rotation of the sealing element, or the up-and-down movement of the cover body also drives the up-and-down movement of the sealing element. It can be further understood that when the sealing element seals the connection channel in a piston-like manner, synchronous movement can seal the connection channel. Of course, if the sealing element and the connection channel are connected by a threaded method, synchronous rotation can also make the sealing element seal the connection channel.

[0028] In some ways, the present invention provides a first cover body for covering the opening of the first chamber for collecting liquid samples. Among them, the first cover body includes a sealing element and a liquid discharging element, or the sealing element and the liquid discharging element are connected to the cover body, or are integrally formed with the cover body. In some preferred ways, when the first cover body covers the opening of the first chamber, the sealing element connected to the first cover body seals the first opening of the connection channel, and the liquid discharging element enters the second chamber. It can be understood that the movement of the first cover body drives the sealing element and the liquid discharging element to move together.

[0029] In the seventh aspect of the present invention, in some preferred ways, the device of the present invention may further include a second cover body for sealing the opening of the second chamber. In some ways, the second cover body is provided on the first cover body. When it is necessary to seal the opening of the second chamber, the second cover body is removed from the first cover body to seal the opening of the second chamber. Therefore, in some ways, the second cover body is located on the first cover body and is provided on the first cover body by means of threads, pistons, pins, etc. In some other preferred ways, the second cover body is detachably located on the first cover body, so that the second cover body can be easily removed from the first cover body.

[0030] In some preferred ways among all the foregoing ways, the second chamber has an opening for collecting liquid samples. In some preferred ways, the opening of the second chamber is in liquid communication with the second opening of the connection channel. In some preferred ways, the second chamber is detachably connected to the connection channel by threads. In some preferred ways, the opening of the second chamber has internal threads and external threads, wherein the internal threads are in mating connection with the external threads of the connection channel. The external threads of the opening of the second chamber are in mating connection with the second cover body covering the opening of the second chamber. Optionally, the second chamber and the second opening of the connection channel may also be detachably connected together by a method other than threads, such as a snap connection method.

[0031] In some preferred ways, the device further includes a test element, and the test element is in liquid communication with the first chamber. In some preferred ways, the device further includes a detection chamber, and the test element is located in the detection chamber.

[0032] In an eighth aspect of the present invention, the present invention provides a method for collecting a liquid sample, providing a device for collecting a liquid sample as described above, the device including a first chamber for collecting a liquid sample; and a second chamber for collecting a liquid sample for performing a confirmation test; wherein, the first chamber and the second chamber are detachably combined, assembled or connected; allowing the liquid sample to enter the first chamber through the opening of the first chamber, and allowing the liquid sample to enter the second chamber from the first chamber.

[0033] In some preferred embodiments, the device includes a connection channel for making the first chamber and the second chamber in liquid communication.

[0034] In some preferred embodiments, the method provides a sealing element, and after the liquid enters the second chamber, the connection channel is sealed with the sealing element.

[0035] In some preferred embodiments, after the sealing element seals the connection channel, the second chamber is separated from the first chamber.

[0036] In some preferred embodiments, after the second chamber is separated from the first chamber, the opening of the second chamber is covered with a cover.

[0037] In some preferred embodiments, the method includes, after separating the second chamber from the first chamber, making the first chamber and the second chamber not in liquid communication. In some preferred embodiments, after separating the second chamber from the first chamber, the second chamber stores the liquid sample from the first chamber. In some preferred embodiments, when the first chamber is collecting the liquid sample or after collecting, the second chamber also collects the liquid sample from the first chamber. In some preferred embodiments, while the first chamber is collecting the liquid sample, the second chamber also collects the liquid sample from the first chamber.

[0038] In some preferred embodiments, the method includes making the first chamber and the second chamber in liquid communication through a connection channel. In some preferred embodiments, before the second chamber is separated from the first chamber, the first chamber and the second chamber are in liquid communication through the channel. In some preferred embodiments, after or simultaneously with separating the second chamber from the first chamber, the first chamber and the second chamber are not in liquid communication, and at the same time the connection channel is sealed. In some preferred embodiments, after separating the second chamber from the first chamber, the second chamber stores the liquid sample from the first chamber. In some preferred embodiments, when the first chamber is collecting the liquid sample or after collecting, the second chamber also collects the liquid sample from the first chamber through the connection channel. In some preferred embodiments, while the first chamber is collecting the liquid sample, the second chamber also collects the liquid sample from the first chamber through the connection channel.

[0039] In some preferred embodiments, the first chamber includes an opening for collecting a liquid sample, and the liquid sample enters the first chamber through the opening. In some preferred embodiments, a connection channel is provided to connect the first chamber and the second chamber, so that the liquid sample can be exchanged between the first chamber and the second chamber through the connection channel. In some preferred embodiments, the liquid sample can flow from the first chamber to the second chamber through the liquid channel. In some preferred embodiments, the connection channel has a first opening and a second opening, wherein the first opening is in liquid communication with the first chamber and the second opening is in liquid communication with the second chamber. In some preferred embodiments, the connection channel is located on or within the first chamber. The second chamber is detachably connected, combined or assembled with the first chamber through the liquid channel.

[0040] In some preferred embodiments, the connection channel has a structure for connecting the first chamber and the second chamber and a structure for separating the first chamber and the second chamber, wherein the structure for connecting the first and second chambers is the space forming the channel. Alternatively, the connection channel has two states, sealed or unsealed. When in the unsealed state, liquid can flow from the first chamber to the second chamber; when the connection channel is in the sealed state, the liquid in the first chamber cannot flow into the second chamber through the connection channel.

[0041] In some preferred embodiments, the method includes: the device includes a first cover for covering the opening of the first chamber for collecting the liquid sample, wherein a sealing element is connected and combined with the cover. In some preferred embodiments, the first cover includes a sealing element. In some preferred embodiments, when the first cover covers the opening of the first chamber, during or after the process, the sealing element connected to the first cover seals the second chamber opening of the connection channel. In some preferred embodiments, the cover includes a second cover for sealing the opening of the second chamber. In some preferred embodiments, the sealing element is detachably connected to the cover. In some embodiments, the sealing element is connected to the cover by means of a thread.

[0042] In some preferred embodiments, the second chamber has an opening for collecting a liquid sample. In some preferred embodiments, the opening of the second chamber is in liquid communication with the second chamber opening of the connection channel. In some preferred embodiments, the second chamber is detachably connected to the connection channel by means of a thread. In some preferred embodiments, the opening of the second chamber has an internal thread and an external thread, wherein the internal thread is matingly connected with the external thread of the connection channel. The external thread of the opening of the second chamber is matingly connected with the second cover covering the opening of the second chamber.

[0043] The detachable connection method of the above-mentioned first chamber and second chamber is to be detachably connected through the structural design of the connection channel and the second chamber, and this detachable connection is a direct connection. In some preferred ways, the second chamber can be detachably connected, combined or joined with the first chamber by means of threaded connection of the channel. When the second chamber and the chamber are directly detachably combined together, the first chamber and the second chamber are in liquid communication. Preferably, the first chamber and the second chamber are in liquid communication through the connection channel. In some preferred ways, the opening of the second chamber is in liquid communication with the second opening of the connection channel. In some preferred ways, the second chamber is disposed on a base, and the base forms a detachable combination with the first chamber. Optionally, the second chamber also forms a detachable combination with the base. Thus, when the base is directly combined with the first chamber, the connection channel of the opening of the second chamber forms a fluid communication. When the base is separated from the first chamber, the second chamber located on the base is separated from the second chamber together with the base. Preferably, when the base is separated from the first chamber, the second chamber located on the base is separated from the connection channel together with the base. In some preferred ways, after the base and the second chamber located on the base are separated from the first chamber, the second chamber is separated from the base. In some preferred ways, after the second chamber is separated from the base, the opening of the second chamber is covered with a second cover body.

[0044] In the sixth aspect of the present invention, the present invention also provides a method for collecting a liquid sample, the method comprising providing the aforementioned device for collecting a liquid sample, the device comprising a first chamber and a second chamber, wherein the second chamber and the first chamber are detachably connected, using the first chamber to collect a liquid sample, and allowing the liquid sample to flow into the second chamber.

[0045] In some preferred ways, when the second chamber has collected a liquid sample, separate the second chamber from the first chamber, so as to cover the opening of the second chamber with a second cover body.

[0046] In some preferred ways, connect the first chamber and the second chamber together through the connection channel, wherein the first opening of the connection channel is in liquid communication with the first chamber, and the second opening of the connection channel is in liquid communication with the second chamber.

[0047] In some preferred ways, the device further comprises a sealing element, and before the second chamber is separated from the first chamber, let the sealing element seal the connection channel.

[0048] In some preferred ways, the device further comprises a cover body, and the cover body and the sealing element are integrally structured. When the cover body covers the opening of the first chamber, the cover body drives the sealing element to seal the second opening of the connection channel at the same time.

[0049] In some preferred embodiments, the cover body drives the sealing element into the connection channel. In some preferred embodiments, after the sealing element seals the connection channel, the second cavity is separated from the first cavity.

[0050] In some preferred embodiments, a liquid discharging element for discharging a part of the liquid in the second cavity is further provided on the cover body, and the cover body drives the liquid discharging element into the second cavity. In some preferred embodiments, a sealing element and a liquid discharging element are provided on the cover body, and the liquid discharging element enters the second cavity prior to the sealing element.

[0051] In some preferred embodiments, the device further includes a liquid repellent channel, and the liquid sample discharged by the liquid discharging element is discharged out of the second cavity through the liquid repellent channel. In some preferred embodiments, the sealing element enters the connection channel, and the liquid discharged by the sealing element is discharged out of the connection channel through the liquid repellent channel.

[0052] In some preferred embodiments, the liquid discharged by the sealing element or the liquid discharging element is discharged into the first cavity through the liquid repellent channel. In some preferred embodiments, a receiving cavity is provided on the cover body, and the receiving cavity is in liquid communication with the liquid repellent channel, wherein the liquid discharged by the sealing element or the liquid discharging element is discharged into the receiving cavity through the liquid repellent channel.

[0053] In a ninth aspect of the present invention, there is provided a method for detecting whether an analyte exists in a liquid sample, the method including the liquid collection device in any one of the above embodiments. After the first cavity collects the liquid sample, a test element is used to detect the liquid sample from the first cavity. After obtaining the detection result, the second cavity is separated from the first cavity in any of the above manners.

[0054] In some specific embodiments, the device further includes a detection cavity for accommodating the test element, and the detection cavity is in fluid communication with the first cavity. When the first cavity collects the liquid sample, the liquid flows into the detection cavity. When the detection cavity includes the test element, after the test element completes the detection, the second cavity is separated from the first cavity. In some preferred embodiments, the liquid sample first enters the detection cavity from the first cavity and then enters the second cavity. Such a structure is as described in the previous structural design, so as to prevent the liquid entering the detection cavity from also entering the second cavity and thus contaminating the liquid sample in the second cavity.

[0055] In a tenth aspect of the present invention, the present invention provides a cover body, on which a sealing element for sealing a connection channel is provided. In some preferred embodiments, a sealing ring is provided on the sealing element. In some preferred embodiments, the materials of the sealing element and the connection channel are the same or different. In some preferred embodiments, the sealing element is made of a flexible material and the connection channel is made of a rigid material. In some preferred embodiments, the sealing element is integrally connected to the first cover body through a connecting rod. In some preferred embodiments, the sealing element further includes an opening of a liquid drainage channel. In some preferred embodiments, the opening of the liquid drainage channel is located below the sealing element, or the opening of the liquid drainage channel enters the connection channel before the sealing element. In some preferred embodiments, the cover body further includes a receiving cavity, which is in liquid communication with the liquid drainage channel. The receiving cavity is in communication with the opening of the liquid drainage channel. In some preferred embodiments, the receiving cavity is located in the sealing element.

[0056] In some other preferred embodiments, a liquid drainage element is further provided on the first cover body, and the liquid drainage element is farther away from the first cover body than the sealing element. Or, the liquid drainage element is provided below the sealing element, or the sealing element and the liquid drainage element are arranged such that the liquid drainage element enters the second cavity before the sealing element, or the liquid drainage element enters the connection channel before the sealing element. Or, when a connecting rod is provided on the cover body to connect the first cover body and the sealing element, the sealing element is connected to the liquid drainage element at the same time. Or, the connecting rod, the sealing element and the liquid drainage element are of an integral structure.

[0057] Advantageous Effects

[0058] Adopting the above structure, it has the characteristics of simple and reasonable structure, low material cost, excellent performance; and is convenient for secondary detection. In particular, when subsequent confirmation detection is required, it is not necessary to send the entire detection device to a testing institution for detection. Instead, only the second cavity is removed from the device and then sent to the detection structure, which is not only safe, but also saves space, cost, and is more environmentally friendly. Description of the Drawings

[0059] Figure 1 is a schematic exploded view of the structure of a collection device in a specific embodiment of the present invention.

[0060] Figure 2 is a schematic perspective view of the cover body in a specific embodiment of the present invention.

[0061] Figure 3 is in a specific embodiment of the present invention Figure 2 the schematic longitudinal sectional structure view of the cover body shown.

[0062] Figure 4 is the schematic longitudinal sectional view of the first cavity in a specific embodiment of the present invention (without the detection cavity).

[0063] Figure 5 It is a longitudinal sectional structural schematic diagram of the second cavity in a specific embodiment of the present invention.

[0064] Figure 6 It is a three-dimensional structural schematic diagram without the first cover in a specific embodiment of the present invention.

[0065] Figure 7 In the present invention Figure 6 It is a longitudinal sectional structural schematic diagram of the device shown, in which the structural schematic diagram of the first cavity and the first cavity combined together.

[0066] Figure 8 It is a partially enlarged structural schematic diagram of the combination of the first cavity and the second cavity in a specific embodiment of the present invention.

[0067] Fig. 9 It is a three-dimensional structural schematic diagram of the combination of the first cavity and the second cavity in a specific embodiment of the present invention.

[0068] Fig.10 It is a three-dimensional structure of the operation process of the first cover covering the opening of the first cavity in a specific embodiment of the present invention.

[0069] Fig.11 It is a three-dimensional structural schematic diagram after the first cover covers the opening of the first cavity in a specific embodiment of the present invention.

[0070] Fig.12 In a specific embodiment of the present invention, Fig.11 It is a sectional structural schematic diagram of the device shown.

[0071] Fig.13 It is a three-dimensional structural schematic diagram in which the second cavity is separated from the first cavity and the second cover is separated from the first cover in a specific embodiment of the present invention.

[0072] Fig.14 It is a three-dimensional structural schematic diagram of the second cover covering the second cavity in a specific embodiment of the present invention.

[0073] Fig.15 It is a three-dimensional structural schematic diagram of the device in another specific embodiment of the present invention.

[0074] Fig.16 It is a three-dimensional structural schematic diagram of the first cavity in a specific embodiment of the present invention.

[0075] Fig.17 It is a three-dimensional structural schematic diagram of the test element carrier in a specific embodiment of the present invention.

[0076] Fig.18Schematic perspective view of the first cover with a sealing element in a specific embodiment of the present invention.

[0077] Fig.19 Schematic perspective view of the first chamber in a specific embodiment of the present invention (without the second chamber).

[0078] Fig. 20 Schematic cross-sectional view of the combination with the second chamber in a specific embodiment of the present invention (enlarged schematic view of a partial structure where the first chamber and the second chamber are detachably combined).

[0079] Fig.21 Schematic perspective view (operation process) of the first cover starting to cover the opening of the first chamber in another specific embodiment of the present invention.

[0080] Fig. 22 In a specific embodiment of the present invention, Fig.21 Schematic cross-sectional view of the device shown (the sealing element does not seal the connection channel and starts to approach the opening).

[0081] Fig.23 Schematic cross-sectional view of the device shown in a specific embodiment of the present invention (the sealing element enters the connection channel).

[0082] Fig.24 Schematic perspective view of the second chamber detaching from the first chamber and the second cover detaching from the first cover in a specific embodiment of the present invention.

[0083] Fig.25 Schematic perspective view of the combination process of the second chamber and the first chamber in the detection or collection device in another specific embodiment of the present invention (the second chamber is located in the tray structure).

[0084] Fig.26 Schematic view of the structure after the combination of the first chamber and the tray in the detection or collection device of the present invention.

[0085] Fig. 27 In the detection or collection device of the present invention, Fig.26 Schematic cross-sectional view of the structure shown.

[0086] Fig.28 Schematic view of the second cover sealing the second chamber in another specific embodiment of the present invention.

[0087] Fig.29 Schematic view of the second chamber leaving the tray.

[0088] Fig.30 Schematic perspective view of the tray without the second chamber being combined with the first chamber.

[0089] Fig.31 Schematic diagram of the three-dimensional structure of the first cover body with a sealing element in another specific embodiment of the present invention.

[0090] Fig.32 For the present invention Fig.31 Schematic diagram of the cross-sectional structure of the first cover body with a sealing element in another specific embodiment shown.

[0091] Fig.33 Schematic diagram of the three-dimensional structure of the first cover body with a sealing element in another specific embodiment of the present invention.

[0092] Fig.34 For Fig.33 Schematic diagram of the cross-sectional structure of the structure shown.

[0093] Fig.35 For the sealing element, the liquid discharging element or Fig.33 Schematic diagram of the structure in which the sealing elements shown are interchanged or one of the components is missing, where Fig.35 A is the cross-sectional view, Fig.35 B is the three-dimensional view.

[0094] Fig.36 Schematic diagram of the principle structure of the separation and combination of the first cavity and the second cavity in some other specific embodiments of the present invention.

[0095] Fig.37 Schematic diagram of the structure of the combination of the first cavity and the second cavity in another specific embodiment of the present invention.

[0096] Fig.38A And Fig.38B Schematic diagram of the separation of the first cavity and the second cavity shown in 37, with the first cavity used for secondary confirmation detection.

[0097] Fig.39 Schematic diagram of the three-dimensional structure principle of the first cavity and the second cavity in some other specific embodiments of the present invention.

[0098] Fig.40 Schematic diagram of the three-dimensional structure principle of the separation and combination of the first cavity and the second cavity in some other specific embodiments of the present invention. Specific embodiments

[0099] The following further describes the structures involved in the present invention or the technical terms used herein. If not specifically specified, they are understood and interpreted according to the general terms commonly used in the art.

[0100] Detection

[0101] Detection refers to assaying or testing for the presence of a substance or material, such as, but not limited to, chemical substances, organic compounds, inorganic compounds, metabolites, drugs or drug metabolites, organic tissues or metabolites of organic tissues, nucleic acids, proteins or polymers. Additionally, detection refers to testing the quantity of a substance or material. Further, assay also refers to immunoassays, chemical assays, enzyme assays, etc.

[0102] sample

[0103] The detection device or collected sample of the present invention includes biological liquids (such as case liquids or clinical samples). Liquid samples or liquid specimens can be derived from solid or semi-solid samples, including excreta, biological tissues and food samples. Any suitable method can be used to convert solid or semi-solid samples into liquid samples, such as mixing, mashing, macerating, incubating, dissolving or digesting the solid sample enzymatically in a suitable solution (such as water, phosphate solution or other buffer solutions). "Biological samples" include those derived from animals, plants and food samples, for example, including urine, saliva, blood and its components, cerebrospinal fluid, vaginal secretions, sperm, feces, sweat, secretions, tissues, organs, tumors, cultures of tissues and organs, cell cultures and media from humans or animals. Preferably the biological sample is urine. Food samples include food processing substances, end products, meat, cheese, wine, milk and drinking water. Plant samples include those derived from any plant, plant tissues, plant cell cultures and media. "Environmental samples" are derived from the environment (for example, liquid samples from a lake or other water body, sewage samples, soil samples, groundwater, seawater and waste liquid samples). Environmental samples can also include sewage or other wastewater.

[0104] Using the suitable detection elements of the present invention, any analyte can be detected. Preferably, saliva and urine are detected using the present invention. Of course, the collection device of the present invention can collect any of the above forms of samples, whether initially solid or liquid, as long as these liquid or liquid specimens flow into the first chamber, and these liquid specimens can flow into the second chamber simultaneously or later. Since the second chamber can be detachably combined, assembled or connected with the first chamber, when subsequent confirmatory detection is required, the second chamber is separated from the first chamber, so that the second chamber can perform secondary detection, while the liquid in the first chamber can perform primary detection. Optionally, the liquid in the second chamber can perform primary detection, while the liquid in the first chamber can perform secondary detection.

[0105] Optionally, after these liquid samples or the processed samples are collected in the liquid state into the first chamber, before or after the initial assay, the second chamber is used to extract a part of the liquid sample in the first chamber for subsequent confirmation assays only. The first chamber can be initially combined with the second chamber, or can be combined during use and then separated.

[0106] Downstream and Upstream

[0107] Upstream or downstream is divided according to the liquid flow direction. Generally, the liquid flows from the upstream to the downstream area. The downstream area receives the liquid from the upstream area, and the liquid can also flow from the upstream area to the downstream area. Here, it is generally divided according to the liquid flow direction. For example, on some materials that use capillary force to promote liquid flow, the liquid can flow in the direction opposite to gravity due to gravity. At this time, the upstream and downstream are still divided according to the liquid flow direction. For example, in the collection device of the present invention, in some preferred embodiments, the first chamber is used as the chamber for collecting liquid samples, and the second chamber is in liquid communication with the first chamber. The liquid entering the first chamber flows into the second chamber. The first chamber can be called the upstream, and the second chamber can be called the downstream. Of course, this flow is the natural flow under the action of the gravity of the liquid. Optionally, this natural flow is the liquid flowing from the first chamber into the second chamber. Of course, the liquid can also flow passively from the upstream to the downstream. For example, in the case of a reaction force, the liquid is forced to flow from the upstream to the downstream, or from a lower position to a higher position. This reaction can be capillary action or the forcing of an external pressure, so that the liquid flows from a lower position to a higher position. The division of upstream and downstream here does not necessarily mean that there must be liquid present. It means that in the case of the presence of liquid, it flows in the order of flow.

[0108] Gas connection or liquid connection

[0109] Gas connection or liquid connection means that liquid or gas can flow from one place to another, and some physical structures may play a guiding role during the flowing process. The so-called passing through physical structures generally means that the liquid passes through the surface of these physical structures or the internal space of these structures and flows passively or actively to another place. Passive flow is generally caused by external forces, such as the flow under capillary action. The flow here can also be due to the action of the liquid or gas itself (gravity or pressure), or it can be a passive flow. Here, the connection does not necessarily mean that there must be liquid or gas present. It only indicates the connection relationship or state between two objects in some cases. If there is liquid present, it can flow from one object to another. This refers to the state of connection between two objects. On the contrary, if there is no liquid connection or gas connection state between two objects, and if there is liquid in one object or on it, the liquid cannot flow to another object or on it. Such a state is non-connection, a state of non-liquid or non-gas connection.

[0110] Detachable combination

[0111] Detachably combined means that the connection relationship between two components is in several different states or positional relationships. For example, when they are two physical components, they can be initially separated. When in a suitable first situation, they are connected or combined together. When in a suitable second situation, the two components can be separated. This separation is a physical separation in space without contact. Or, the two components are initially combined together. When in a suitable situation, the two components can be physically separated in space. Or, the two objects are initially separated, combined together when needed to complete a certain function, then separated, or later combined again for a certain purpose. In short, the combination or separation between the two can be easily carried out, and this combination or separation can be repeated multiple times in a cycle. Of course, it can also be a one-time combination and separation. In addition, it can be the detachable combination between two components, or the pairwise detachable combination between three or more components. For example, there are a first, a second, and a third component. The first component and the second component are detachably combined, the second component and the third component can also be detachably combined, and the first component and the third component can also be detachably combined or separated. In addition, the combination method can be that the two objects themselves are detachable, or they can be indirectly combined through other objects.

[0112] Test components

[0113] As used herein, the so-called "test element" refers to any element that can detect whether a sample or specimen contains an analyte of interest, and such detection can be based on any technical principle, such as immunology, chemistry, electrochemistry, optics, molecular biology, nucleic acids, physics, etc. The test element can be a lateral flow test strip, which can detect a variety of analytes. Of course, other suitable test elements can also be used in the present invention.

[0114] Various test elements can be combined and used in the present invention. One form is a test strip. The test strip for analyzing an analyte (such as a metabolite indicating a physical condition) in a sample can be in various forms, such as in the form of an immunoassay or a chemical analysis. The test strip can adopt a non-competitive or competitive analysis mode. The test strip includes a water-absorbing material having a sample application area, a reagent area, and a test area. Add the sample to the sample application area, and it flows to the reagent area by capillary action. In the reagent area, if the analyte is present, the sample binds to the reagent. Then the sample continues to flow to the test area. Some other reagents, such as molecules specifically binding to the analyte, are immobilized in the test area. These reagents react with the analyte (if present) in the sample and bind the analyte in this area, or bind to one of the reagents in the reagent area. A marker for displaying a detection signal is present in the reagent area or a separate marker area.

[0115] In a typical non-competitive analysis mode, if the sample contains the analyte, a signal will be generated, and if it does not contain the analyte, no signal will be generated. In the competitive method, if the analyte is not present in the sample, a signal is generated, and if the analyte is present, no signal is generated.

[0116] The test element can be a test strip, and materials that absorb water or do not absorb water can be selected. The test strip can include various materials for liquid sample transfer. One material of the test strip can cover another material, such as filter paper covering a nitrocellulose membrane. One or more materials can be selected for one area of the test strip, while one or more other different materials can be selected for another area. The test strip can be adhered to a support or a rigid surface to improve the strength of holding the test strip.

[0117] The analyte is detected through a signal generation system. For example, one or more enzymes that specifically react with the analyte are used, and by the method of immobilizing specific binding substances on the test strip as described above, a composition of one or more signal generation systems is immobilized in the analyte detection area of the test strip. The substance generating the signal can be in the sample application area, the reagent area, or the test area, or throughout the test strip, and this substance can fill one or more materials of the test strip. Add a solution containing the signal substance to the surface of the test strip or immerse one or more materials of the test strip in a solution containing the signal substance. Dry the test strip to which the solution containing the signal substance is added.

[0118] The various regions of the test strip can be arranged in the following manner: sample application region, reagent region, detection region, control region, region for determining whether the sample is adulterated, and liquid sample absorption region. The control region is located after the detection region. All the regions can be arranged on a single test strip made of only one material. Or different regions can use different materials. Each region can be in direct contact with the liquid sample, or different regions can be arranged according to the flow direction of the liquid sample, with the ends of each region connected and overlapping with the front ends of another region. The materials used can be materials with good water absorption properties such as filter paper, glass fiber, or nitrocellulose membrane, etc. The test strip can also be in other forms.

[0119] The commonly used reagent strip is usually a nitrocellulose membrane reagent strip, that is, the detection region includes a nitrocellulose membrane, and specific binding molecules are immobilized on the nitrocellulose membrane to show the detection result; it can also be an acetate cellulose membrane or a nylon membrane, etc. For example, some reagent strips or devices containing reagent strips described in the following patents: US 4857453; US 5073484; US5119831; US 5185127; US 5275785; US 5416000; US 5504013; US 5602040; US 5622871; US5654162; US 5656503; US 5686315; US 5766961; US 5770460; US 5916815; US 5976895; US6248598; US 6140136; US 6187269; US 6187598; US 6228660; US 6235241; US 6306642; US6352862; US 6372515; US 6379620; and US 6403383. The test strips and similar devices with test strips disclosed in the above patent documents can all be applied to the test element or detection device of the present invention for detecting the analyte, such as detecting the analyte in the sample.

[0120] The test strips applied to the present invention can be the commonly referred to lateral flow test strips. The specific structures and detection principles of these test strips are well-known to those of ordinary skill in the art in the prior art. Ordinary test strips include a sample collection area, a labeling area, a detection area, and a water absorption area. The sample collection area includes a sample receiving pad, the labeling area includes a labeling pad, and the water absorption area can include a water absorption pad. The detection area includes the necessary chemical substances for detecting whether the analyte is contained, such as immunoassay reagents or enzyme chemical reagents. Commonly used test strips are nitrocellulose membrane test strips, that is, the detection area includes a nitrocellulose membrane, and specific binding molecules are immobilized on the nitrocellulose membrane to display the detection results; it can also be a cellulose acetate membrane or a nylon membrane, etc. Of course, a detection result control area can also be included downstream of the detection area. Usually, the control area and the detection area appear in the form of horizontal lines, which are the test line or the control line. Such test strips are traditional test strips. Of course, it can also be other types of test strips that utilize capillary action for detection. In addition, generally, the test strips carry dry chemical reagent components, such as immobilized antibodies or other reagents. When encountering a liquid, the liquid flows along the test strip by capillary action. As it flows, the dry reagent components dissolve in the liquid, and then react with the dry reagents in the next area to perform the necessary detection. The liquid flow is mainly carried out by capillary action. The descriptions and records of these test elements can be found in the following documents: "Research on the Regeneration Treatment of Nitrocellulose Membrane and Its Ability to Adsorb Proteins" by Li Fugang; "Analysis of the Performance of Chromatographic Membrane Materials in Colloidal Gold Diagnostic Kits" by Ma Hongyan, etc.; "A New Type of Colloidal Gold Immunochromatographic Test Strip" by Wang Yong, Wang Luhai, etc. All of these can be applied to the detection device of the present invention, or be arranged in the detection chamber to contact the liquid sample, or be used to detect whether the analyte exists or the quantity of the analyte existing in the liquid sample entering the detection chamber.

[0121] In addition to using the above test strips or lateral flow test strips themselves to contact the liquid in the first chamber to test whether the liquid sample contains the analyte. In some preferred embodiments, the test elements can also be arranged on some carriers, such as on some cards 106. The cards have many grooves, and the test elements are located in the grooves. The entire test card is arranged in the detection chamber 105, and the sample application area of the test element is located at the bottom 1051 of the detection chamber to contact the liquid sample. Such a liquid sample can come from the first chamber 103. For example, the liquid sample is in liquid communication with the first chamber through the through hole 1038 between the detection chamber 105 and the first chamber (such as Fig. 9 and Figure 1 shown). It is also possible to place the sample loading area of the test element in the sample collection area of the detection chamber to contact the liquid sample, thereby completing the detection of the analyte.

[0122] In another way, for example Fig.16 and Fig.17 as shown, a carrier 206 is provided. There are multiple channels on the carrier, one end of each channel is sealed 2062 and the other end is open 2063. One or more test strips are arranged in the channels. The sample application area of the test strip is located at one end of the opening 2063. There is one or more channels for accommodating the test strips in the carrier 206. Each channel is provided with a test element. When there are multiple channels, test elements for different analytes can be arranged in each channel. In this way, multiple analytes can be detected using the same sample. Such a carrier 206 is placed in the first chamber 203. There are two limiting strips 2032 and 2033 on the wall of the chamber 203. The carrier 206 is inserted or snapped into the two limiting grooves, so that one end 2065 of the channel with an opening is close to the bottom of the first chamber, and one end 2064 with a sealed channel is close to the opening 2031 of the first chamber( Fig.16 ). When the liquid sample flows into the first chamber through the opening 2031 of the first chamber, the liquid sample contacts the sample application area of the test strip, thereby completing the detection. Such a carrier is specifically described in the US patent application with application number 15 / 644,148 and the Chinese patent applications with application numbers 2016106132817 and 2016106079834 filed by the present applicant. Of course, in addition to the carriers disclosed in the above patents, other carriers can also be used in the present invention as carriers for carrying test strips.

[0123] For example, in some ways, the first chamber can first collect the liquid sample, and then use a separate test element to detect the analytes in the liquid sample in the first chamber. A test strip or a card or a carrier with a test strip is inserted into the first chamber for detection. Those of ordinary skill in the art can understand that according to the description of the present invention, these test strips may not be arranged on the carrier but exist independently. The detection chamber 105 of the present invention can also be missing in some cases, and the test strips can also be missing in some cases. This will be described in detail later.

[0124] Analyte

[0125] Examples of analytes that can be used in the present invention include some small molecule substances, which exist in body fluids such as blood, urine, saliva, sweat, etc. or some of the body fluids contain the above small molecule substances.

[0126] For example, analytes detected using the present invention include, but are not limited to, creatinine, bilirubin, nitrite, protein (non-specific), hormones (e.g., human chorionic gonadotropin, progesterone hormone, follicle-stimulating hormone, etc.), blood, white blood cells, sugar, heavy metals or toxins, bacterial substances (such as proteins or carbohydrate substances specific to specific bacteria, such as Escherichia coli 0157:H7, Staphylococcus, Salmonella, Clostridium, Campylobacter, L. monocytogenes, Vibrio, or Bacillus cereus), and substances related to physiological characteristics in urine samples, such as pH and specific gravity. Any other clinical urine chemical analysis can be performed using the lateral flow detection format in conjunction with the device of the present invention.

[0127] Liquid Flow

[0128] The flow of a liquid generally refers to the movement from one place to another. Generally, the flow of liquids in nature mostly relies on the action of gravity to flow from a higher place to a lower place. Here, the flow also depends on an external force, that is, the flow under the external gravity, which can be called the flow of natural gravity. In addition to gravity, the flow of a liquid can also overcome gravity and move from a lower place to a higher place. For example, the pumping of a liquid, or the compression of a liquid, or the liquid being under pressure and flowing from a lower place to a higher place, or the flow due to the application of pressure overcoming the self-gravity of the liquid. For example, Fig. 9 , Fig.19 , Fig. 22 , Fig. 27 in which, the first chamber is located above the second chamber, and the second chamber is located below the first chamber. When a liquid enters the second chamber, the liquid can naturally flow from the first chamber to the second chamber by relying on its own gravity, or can flow naturally from the upstream to the downstream position.

[0129] Detection device or collection device

[0130] A detection device refers to a device used to detect whether an analyte is contained in a sample. A collection device refers to the collection and storage of a liquid sample. The detection device may include the collection device, the collection device may also include the detection device, or the collection device and the detection device are separated, and during detection, the collection device and the detection device are combined to complete the detection. It may also be that the collection device and the detection device are an integrated structure device. Once the liquid sample is collected, the detection can be immediately carried out to obtain the test result, and at the same time, the test sample and the collected sample are separated, so that a secondary detection can be carried out (if necessary). Here, the detection device or the detection cavity can be interchanged, and the collection device and the collection cavity can also be interchanged, only the functions are interchanged due to different functions. For example, when referring to the collection device in the present invention, it may not include the detection cavity or the test element, but the collection device may include a test element or a carrier containing the test element. The collection device containing the test element can also be called the detection device. Of course, the collection device may include a space for setting the test element, but it does not necessarily have to contain the test element. The test element can be combined with the collection device at any subsequent appropriate time to become the detection device. For example, the collection device may include a space for accommodating the test element, such as containing the detection cavity 105( Figure 7 ), or there is a suitable position in the liquid collection cavity of the collection device to set the test element or the carrier containing the test element( Fig.16 ). Therefore, the present invention can be a device designed only for collecting liquid samples, or a detection device that performs detection while collecting.

[0131] The first cavity and the second cavity can be detachably combined, combined or matched

[0132] The first chamber and the second chamber of the present invention can form a detachable pair combination. Before liquid collection is required, the first chamber and the second chamber are already combined together. After the liquid sample collection is completed, the second chamber can be separated from the first chamber. Or, the first chamber and the second chamber are separated, and when liquid sample collection is required, they are combined together, and after the collection is completed, the first chamber and the second chamber are separated. In some specific embodiments of the present invention, such as Figure 1-Figure 14 shown in a specific manner, the present invention provides a detection device for detecting whether an analyte is contained in a liquid sample, or a collection device for collecting a liquid sample, which includes a first chamber 103 and a second chamber 104. The first chamber 103 can be used as a collection chamber, that is, for collecting liquid samples, and the first chamber and the second chamber are combined, connected, or assembled in a detachable manner.

[0133] "Combination, connection or assembly" here actually means the same thing, just with different words used, all of which can mean being joined together, and this joining is the opposite of "separation". Both joining and separation can occur under any conditions and can be freely chosen. In some ways, when the first chamber and the second chamber are combined, the first chamber and the second chamber are in a state of liquid flow. In other ways, before, during or after the separation of the first chamber and the second chamber, the first chamber and the second chamber are not in a state of liquid flow.

[0134] In some preferred ways, the device further includes a connection channel, and the first chamber is detachably joined, combined or assembled with the connection channel. Thus, a detachable combination, connection or assembly with the second chamber is achieved. Fig. 9 As shown, the first chamber 103 is used as a collection chamber. It has an opening 1031 for collecting or receiving a liquid sample. The liquid sample flows into the first chamber 103 through the opening. At the bottom of the first chamber, there is a connection channel 109. The connection channel has a first opening 1091 and a second opening 1092 at the other end. The first opening 1091 of the connection channel 109 and the first chamber 103 are in liquid communication. The liquid sample in the first chamber can flow into the connection channel 109 through the opening 1091 and then flow out through the second opening 1092 at the other end. Therefore, the present invention provides a chamber for collecting a fluid sample. The chamber includes an opening 1031 for the fluid sample to enter the chamber 103. At the bottom of the collection chamber, there is a channel that has a first opening and a second opening. Part of the liquid sample can enter the connection channel through the first opening 1091 of the connection channel and flow out through the second opening 1090 of the connection channel. "Flow out" means flowing out of the first chamber 103. Preferably, the liquid flowing out of the connection channel enters the second chamber 104. Therefore, the collection device may further include a second chamber. Generally, the first chamber has an opening, side walls and a bottom to enclose a chamber. The connection channel is generally located on the bottom of the first chamber. In this specific embodiment, the connection channel is located in the area of the bottom. However, it is not limited to the position of the connection channel. It can be located on the side wall or at the junction of the bottom and the side wall. Any position is acceptable as long as the liquid sample entering the collection chamber 103 can enter the connection channel.

[0135] The meaning of "connection channel" here generally refers to a structure that connects the first chamber and the second chamber, allowing the first chamber and the second chamber to be connected or combined when needed, and in some cases, allowing the second chamber to be separated from the first chamber. In fact, here, the connection channel plays two functions simultaneously. One is to connect the first chamber and the second chamber in a detachable manner, and the other structure also serves as a liquid communication between the first chamber and the second chamber, enabling liquid to flow between the two chambers through this structure, such as a tube, a groove, or other means. Therefore, the use of "connection channel" is a preferred embodiment of the present invention. It can be understood that in a more preferred solution here, the connection and the channel that allows liquid communication between the first chamber and the second chamber are formed by the same structure to perform two different functions. For example, the tube-shaped structure of the present invention, Fig. 9 or Fig. 9 and Figure 4 the shown connection channel simultaneously connects the second chamber to the first chamber and also serves as a structure in a liquid communication state. It can be understood that the mechanism of the connection channel can be defective, which will be described in detail in other embodiments later. Of course, the understanding of "connection channel" here can also only play a connecting role, connecting or combining the second chamber and the first chamber in a detachable manner, without having the function of liquid communication between the second chamber and the first chamber; alternatively, the "connection channel" here can also be understood as only serving the function of liquid communication between the second chamber and the first chamber, without having the function of connecting the first chamber and the second chamber. Alternatively, the "connection channel" here can also be understood as described above, that is, having the function of connection and also having the function of liquid communication.

[0136] In some preferred ways, there is an external thread on the outside of the second opening of the connection channel. Provide a second chamber 104, the second chamber 104 has an opening 1042, the outer diameter size of the second opening 1042 is equivalent to or slightly larger than the outer diameter of the connection channel, and there is an internal thread on the inside of the opening of the second chamber 104. In this way, through the cooperation of the external thread of the connection channel and the internal thread of the second chamber, the second chamber and the first chamber can be detachably fitted, combined, or connected. That is, when combining, directly connect the second chamber to the connection channel by means of threads; when disassembly is required, reverse the threads to separate the second chamber 104 from the connection channel, and thus separate from the collection chamber 103. Or, an internal thread is provided in the second opening 1092 of the connection channel, and an external thread is provided on the outside of the opening 1042 of the second chamber 104. The internal thread of the channel opening cooperates with the external thread of the second chamber, so that the first chamber and the second chamber are assembled or connected in a detachable manner. When the second chamber is separated from the first chamber, use a second cover to cover the opening 1042 of the second chamber to seal the second chamber.

[0137] Of course, alternatively, as Fig. 9 As shown, the outer wall of the second opening 1092 of the connection channel has no threads. Instead, a narrow space 1098 is provided on the outer wall of the second opening 1092 of the connection channel 109. This narrow space can just cooperate with the opening of the second chamber 104, that is, cooperate with the thickness of the opening of the second chamber. For example, the narrow space is composed of the outer wall 1095 of the second opening 1092 of the connection channel and the corresponding wall 110 (as shown in Figure 8 ). A threaded structure is provided on the wall 110, and this threaded structure cooperates with the external threads at the opening 1042 of the second chamber 104, so that the external threads of the second chamber can cooperate with the threads on the wall 110, thus realizing the combination of the first chamber and the second chamber. This combination is also completed through the cooperation between the inner wall of the opening of the second chamber and the outer wall of one end 1092 of the connection channel. The second chamber 104 and the first chamber 103 are detachably mated, combined or connected. In order to make the first chamber and the second front have a better sealing and mating relationship, a second sealing ring 107 can be provided inside the opening of the second chamber, which makes the inner wall of the opening of the second chamber fit more tightly with the outer wall of the connection channel, thereby preventing the liquid sample entering the second chamber 104 from leaking (as shown in Figure 8 and Fig. 9 ). Those of ordinary skill in the art should understand that the so-called "detachable" here means that two objects can be combined together to form an integral structure when needed, and when it is necessary to separate the two objects, they can be easily separated. This separation is mainly a physical separation in terms of spatial structure and non-contact.

[0138] In addition to the form of connection by threads, this detachable method can also be in any other form, such as the form of snap fasteners, the form of pistons, the form of plug-in connections, the form of lock catches, etc., as long as the first chamber and the second chamber can be combined and connected together when needed, so as to obtain a part of the liquid sample from the first chamber, and when it is necessary to separate the two, the first chamber and the second chamber can be separated. For example, in the form of threads, it is rotated in the opposite direction to separate from the first chamber; or in other ways, such as the way of pulling out, unlocking, so that after the second chamber 104 obtains the liquid sample from the first chamber, it can be easily separated from the second chamber. This way of obtaining liquid can keep the liquid communication when the first chamber 103 and the second chamber 104 are connected.

[0139] Of course, in a specific implementation manner, which is also a preferred manner, the connecting channel 109 and the first chamber 103 are integrally injection-molded, while the second chamber 104 is injection-molded separately, and the second chamber is detachably combined, joined or assembled with the connecting channel. It can be understood that it is also feasible that the connecting channel 109 and the second chamber 104 are integrally injection-molded, and the connecting channel 109 and the second chamber 104 together are detachably combined, joined or assembled with the first chamber 103.

[0140] Therefore, it is also possible that the function of so-called "connection" is completed by a single structure itself, and the state of liquid communication between the first chamber and the second chamber is completed by another structure. Such a way is also easy to understand. For example, the first chamber and the second chamber are connected together in a detachable manner through a connecting mechanism, and the liquid cannot flow between the second chamber and the first chamber through the connecting mechanism itself, but through another structure, such as a channel, to allow the liquid to flow from the first chamber to the second chamber. Therefore, it can be understood in this way that in some preferred ways, the device further includes a connecting structure, and the first chamber and the second chamber are detachably joined, combined or assembled through the connecting structure. When connected through the connecting structure, the first chamber and the second chamber are in a liquid flow state. Here, the liquid flow can be achieved through another structure, such as a tube, a channel, or a groove, to make the two chambers in a liquid flow state.

[0141] Those of ordinary skill in the art can understand that the connecting channel 109 here can be omitted. As long as when the first chamber collects a liquid sample, the liquid sample can reach, for example, the second chamber connected to the first chamber, and when it is necessary to separate the second chamber from the first chamber, it is easy to separate the second chamber from the first chamber. Such a way can be other suitable ways that those of ordinary skill in the art can think of when seeing the essence of the present invention. For example, Fig.36 as shown, there is a hole 903 on the side wall of the first chamber 903, which is initially sealed by a film that is easily pierced or self-sealing silicone, rubber, or soft plastic. When it is necessary to collect a sample, the first chamber 903 is used to collect the sample. After collecting the liquid sample, a second chamber 904 (which is not initially connected to the first chamber) is provided, and the opening part of the second chamber pierces the sealing film (not shown) on the first chamber, so that the liquid in the first chamber flows into the second chamber, and then is separated from the first chamber again, so as to perform a secondary detection on the liquid in the second chamber. Another example is, as Figure 37-Figure 3 shown in FIG. 8, the first chamber and the second chamber are not detachably combined through a connecting channel, but the first chamber and the second chamber are detachably combined through a mutually matching threaded structure. Another example is Figure 25-27 as shown, they are detachably combined through a tray structure, which will be described in detail below.

[0142] Optionally, referring to Figure 8 , the present invention designs a connection channel 109 to connect the opening 1042 of the second chamber 104. Of course, the connection channel 109 may not be required, but the opening part 1042 of the second chamber 104 can be used as the connection channel, and the opening 1042 of the second chamber is directly connected to the inside of the first chamber. This connection can be in the form of snap connection, piston type, or lock. At this time, there is a hole at the bottom of the first chamber. As long as the opening 1042 of the second chamber corresponds to the hole, the liquid can flow from the first chamber to the second chamber. Preferably, the first chamber and the second chamber are connected together before the first chamber collects the sample, which is convenient for separation when the second chamber needs to be separated from the first chamber.

[0143] In some other preferred ways, the first chamber and the second chamber are detachably connected, combined, or joined, rather than Fig.33 shown as the direct detachable connection of the first chamber and the second chamber without passing through another structure, nor Figure 8-Figure 9 , Figure 1 , Figure 22-Figure 23 shown as the indirect detachable connection of the first chamber and the second chamber through a connection channel, but Figure 25-Figure 30 shown as the detachable connection or combination. The following will be elaborated in detail.

[0144] Therefore, another aspect of the present invention provides a collection or detection device, which includes a first chamber for collecting a liquid sample; and a second chamber for performing a confirmatory secondary detection. The device further includes a tray structure, which is detachably combined, joined, or assembled with the first chamber. In some ways, the second chamber is located on the tray, that is, the detachable combination or joining between the second chamber and the first chamber is indirectly achieved through the detachable combination or joining between the tray and the first chamber, that is, the tray structure and the second chamber are in a linkage manner. Here, the linkage generally drives the movement of the second chamber by the movement of the tray, so as to achieve separation from the first chamber. Then, after the linkage, separation or non - separation from the tray structure can be achieved.

[0145] At this time, the connection channel may or may not be present. Therefore, the communication structure is not necessary. For example, as Figure 25-Figure 30 shown, the second cavity is located on a base structure or a tray structure 1004, and the opening of the second chamber is still in liquid communication with the connection channel (with a connection channel). However, it is not necessary to rely on the direct connection of the second cavity and the connection channel by its own structure to achieve liquid conduction as described above. In this specific embodiment, it only needs the opening of the second chamber to be joined with the second outlet of the connection channel, and the base structure 1004 is joined with the bottom of the first chamber 103 through a matching structure ( Fig. 27), such a mating structure is in the form of a thread. In this way, the base structure has a thread, such as an external thread, while the bottom of the first chamber has an internal thread, and the two are combined together by means of the thread, and the second chamber and the connection channel are closely fitted through the binding force of the thread. Specifically, in the following way: for example, as Figure 25-28 shown, the second chamber 304 is located on a base tray 1004, and the base tray 1004 is detachably connected to the first chamber, and the second chamber 304 is also detachably combined with the base tray 1004. Specifically, the tray structure 1004 has an internal thread, which cooperates with the external thread 3031 extending from the bottom of the first chamber 303, so as to realize the detachable combination of the tray structure 1004 and the first chamber 303. In this way, if there is still a connection channel, as Fig. 27 shown, the connection channel 309 can still have a first opening 3091 in fluid communication with the first chamber and a second opening 3092 in fluid communication with the second chamber, and the connection channel has an extension section 3098, which extends into the opening 3052 of the second chamber and contacts the inner wall of the opening 3041, and can be snap-fitted together, that is: the outer diameter of the extension area matches the inner diameter of the opening 3041. Although the second chamber and the first chamber can also be snap-connected through the connection channel 109 as Fig. 27 shown, this connection does not require a very firm connection, and does not require a connection as tight as Figure 8-Figure 9 shown (by means of threads, etc.), because the tray structure 1004 cooperates with the external thread 3031 of the extension section of the first chamber 103 through the thread 10041, so no matter how much liquid sample the second chamber 304 collects, there will be no leakage problem between the connection channel 109 and the opening 1042 of the second chamber. Therefore, the inner diameter of the connection channel 109 can be smaller than the inner diameter of the opening 1042 of the second chamber, so that the connection channel can be inserted into the opening 3042 of the second chamber, and this insertion method can be easily inserted ( Fig. 27 shown). And only threads are provided on the outer edge of the opening of the opening 3042 for the covering of the second cover (as Fig. 27 ). At this time, the connection between the connection channel and the opening of the second chamber only needs to ensure no leakage when collecting the liquid sample, that is, it can allow the liquid to enter the second chamber, and no more structural restrictions are required. This connection can be in the form of snap connection, piston type, or lock. In fact, the detachable combination, combination or engagement of the first chamber and the second chamber is completed in an indirect way.

[0146] After the collection is completed, after sealing the connection channel and / or draining the second cavity according to the method described later, if a second confirmation test is required, separate the tray structure 1004 from the first cavity 103, for example, by reverse-rotating the threaded structure where the tray mates with the bottom of the first cavity. At this time, the second cavity 104 on the tray also separates from the first cavity 103 together with the tray structure, as Fig. 27 , at this time, remove the second cover 101 and cover the opening 3042 of the second cavity. Then separate the second cavity from the tray 1004 (as Fig.29 ), because there is a snap structure 10042 at the bottom of the second cavity and the bottom of the tray, so the tray and the second cavity will separate from the first cavity 103 together. Then, after removing the tray 1004 from the second cavity 304, reconnect and combine the tray 1004 with the first cavity 103 separately again. At this time, the integrity of the first cavity is still maintained, and the second cavity can be sent to a confirmed testing agency for a second confirmation test. In order to make the second cavity 304 separate from the first cavity as the tray moves, there is a snap ring 10042 on the tray, and the shape of the snap ring adapts to the cavity shape of the second cavity 304. For example, the cavity of the second cavity is U-shaped, and the snap ring 10042 is also U-shaped. In this way, when the tray structure 1004 rotates, it drives the second cavity 304 to rotate together. Since the second cavity and the snap ring can fit slightly tightly, naturally the second cavity 304 separates from the first cavity 303 together with the tray structure 1004. Of course, in some ways, the second cavity is a structure similar to a cube, and 4 snap structures are provided on the tray to snap the second cavity and the snap structures together, so as to drive the movement of the second cavity by the movement of the tray, and thus realize the separation of the second cavity from the first cavity.

[0147] At this time, in order to ensure the safety of the second cavity after being covered by the second cover, a seal can be pasted on the second cavity, and the seal covers the second cover and part of the second cavity. Ensure that the sample in the second cavity is not maliciously replaced, and keep the liquid in the second cavity consistent with the original sample in the first cavity. Of course, optionally, the tray 1004 and the second cavity can be packaged and transported together, and the seal covers the second cavity, the tray, and the cover for sealing the second cavity, so as to form an integral structure for transportation. It is also understandable that the base structure 1004 and the second cavity 104 are an integral structure and are of one-piece injection molding structure. In this way, when the base 1004 is combined with the first cavity 104, the second cavity 104 is also combined with the connection channel 109.

[0148] Optionally, the connection channel and the extension section 3098 here can be omitted, because only a hole needs to be opened at the bottom of the first cavity 103, and the size of the hole is less than or equal to the opening 3042 of the second cavity 304, and there is no need for the connection channel to have an extension section (as Fig. 27), the first opening 3091 of the connection channel can function as the bottom hole. In this way, when the second cavity is combined with the first cavity through the tray, the opening 1042 of the second cavity corresponds to the position of the bottom opening (similar to the position of 3091 in the figure) of the first cavity 103. Relying on the cooperation between the tray 1004 and the first cavity 303, the opening of the second cavity 304 forms a tight fit or a tight contact with the area around the hole, so that the second cavity and the first cavity form a liquid flow state. When the first cavity collects liquid, the liquid will also flow into the second cavity. If it is necessary to separate the first cavity 103 and the second cavity, seal the hole at the bottom of the second cavity (similar to Fig. 27 the position shown as 3091), so that the tray 1004 is separated from the first cavity 103, driving the second cavity 103 to be separated from the first cavity together. The same function is also achieved. Optionally, the hole is initially sealed by an easily punctured sealing material. After collecting liquid or starting the detection, the sealing material is punctured to allow the liquid to flow into the second cavity. The method of the sealing element will be specifically described later.

[0149] After the liquid collection in the first cavity is completed, the second cavity can be separated from the first cavity, so that the second cavity can store or be transported to a testing institution for secondary confirmation testing. The liquid in the first cavity can be used for the first or initial testing. Or, after the liquid collection in the first cavity is completed, the second cavity can be separated from the first cavity. After separation, the liquid in the first cavity is subjected to the initial testing. After obtaining the test result, the separated second cavity can be stored or directly sent to the testing structure for the second confirmation testing. Or, after the liquid sample collection is completed, the liquid sample in the first cavity is tested. After obtaining the initial test result, the second cavity is separated from the first cavity, and the separated second cavity is used for storage or subsequent second confirmation testing.

[0150] Of course, the liquid in the first cavity can be stored and subjected to the initial testing at an appropriate time. In some preferred methods, it is desired that after the liquid in the first cavity is collected, the corresponding initial or first testing is carried out simultaneously. After the test result is obtained, for some of the initial test results, if necessary, secondary confirmation testing is carried out. Once the initial testing is only a preliminary test to determine whether there is still the analyte in the sample, the detection sensitivity generally does not need to be very high. Sometimes, when the analyte in the sample is at the critical threshold, the initial test result cannot give a positive or negative result. At this time, it is desired to carry out secondary confirmation testing on the same part of the sample.

[0151] As for whether to use the second chamber or the first chamber for confirmation of the second detection after the separation of the first chamber and the second chamber, for example, the first chamber can be used for the second detection while the liquid sample in the second chamber is used for the initial detection, which can both be achieved. Therefore, it is not limited that only the second chamber can be used for confirmation detection. In some ways, for example Fig.37 As shown in FIGS. 38 and Fig.37 , the present invention provides a first chamber 603 for collecting a liquid sample and a second chamber 604 for performing an initial detection. The second chamber has a detection chamber 605, and the detection chamber and the second chamber have a liquid communication through hole 6038. The first chamber has an opening 6031, and a connection channel 609 is provided at the bottom of the first chamber. The connection channel has a first opening 6091 in liquid communication with the first chamber and a second opening 6092. The first opening is sealed by a sealing element, which is a shell-piercing sealing element, such as a film, double-sided tape, aluminum foil, etc. In this way, when the first chamber is used to collect the liquid sample, the liquid will not flow out through the first opening of the connection channel at the beginning. After the first chamber collects the liquid sample, it is combined with the second chamber. For example, the external thread 6031 of the first chamber and the internal thread of the second chamber are used for combination, or the first chamber and the second chamber are initially combined by means of threads, and the first chamber 603 is used to directly collect the liquid sample. After collection, a sealing element 6028 and a piercing element 6029 are used to pierce the sealing element sealing the first opening of the connection channel, and the liquid is released into the second chamber 604 for the initial detection. The liquid enters the detection chamber 605 for the initial chemical test. When a second confirmation detection is required, the first chamber is detached from the second chamber, and the opening of the first chamber is sealed with a cover body, so as to perform the second confirmation detection on the liquid sample in the first chamber. An optional method is that the cover body used to seal the first chamber includes the sealing element 6028 and the piercing element 6029, and a first chamber has an extended channel 610 corresponding to the first opening 6091 of the connection channel 609. The channel extends into the first chamber. In this way, when the cover body covers the first chamber, the cover body, the sealing element 6028 and the piercing element 6029 form a linkage relationship, so as to drive the sealing element and the piercing element to move together. When the piercing element pierces the first opening 6091 of the sealed connection chamber, the sealing element pushes the liquid in the channel 610 into the second chamber for the initial chemical test, and at this time the cover body seals the opening of the first chamber. As shown in the upper figure of FIG. 38. When a second chemical test confirmation is required, the first chamber 603 is detached from the second chamber 604, and then the second opening of the connection channel is sealed with a second cover body, for example, by means of threads, and then the first chamber 603 is sent to a testing institution for a second confirmation detection, as shown in the lower figure of FIG. 38.

[0152] Of course, the piercing element may also have the function of discharging a part of the liquid in the second chamber. At this time, the piercing element may also have a liquid-repellent channel, a liquid inlet, and a receiving chamber. In this way, after piercing the first opening 7091 of the piercing and sealing connection channel, the piercing element is directly partially inserted into the second chamber. In order to discharge the liquid, the liquid can flow into the receiving chamber through the liquid inlet of the liquid-repellent channel. For example, the receiving chamber is located in the piercing element. This can be clearly understood and combined with the following detailed description.

[0153] In some alternative ways, when used as a detection device, the collection device further includes a test element that can test the collected sample. For example, the collection device includes a detection chamber, where the detection chamber is in liquid communication with the first collection chamber, that is, the liquid sample in the first chamber can flow into the detection chamber. Of course, including a detection chamber in the detection device here is only a preferred embodiment. When used as a collection device, the detection chamber may be absent, or the detection device includes a detection chamber but does not carry a test element. When detection is required, a detection element is inserted into the detection chamber. In some specific embodiments, a detection chamber 105 is provided outside the side wall of the first chamber, and the first chamber 103 and the detection chamber 105 are in liquid communication (such as Fig. 9 ). If there is a liquid sample in the first chamber 103, the liquid can be in liquid communication through the through hole 1038 provided in the detection chamber 105 and the collection chamber 103, and then enter the detection chamber for necessary preliminary tests or detections.

[0154] Generally, the sensitivity of detecting the liquid sample in the first chamber 103 (the first or preliminary detection) is not as high as that of the secondary confirmation detection, or the specificity of the first or preliminary detection is not as accurate as that of the secondary confirmation detection. In this way, the secondary detection can basically confirm whether the preliminary detection is truly accurate. For example, the preliminary detection relies on immunological and chemical methods, while the secondary confirmation detection generally uses mass spectrometry (GS), gas or liquid chromatography. This secondary detection is generally performed on the liquid sample in a second chamber separated from the first chamber because the first chamber and the second chamber are both for the same sample, and their properties are the same, only divided into different parts. The second detection can confirm the preliminary detection.

[0155] In some preferred ways, while the first chamber 103 is collecting the liquid sample or within a very short time after the collection is completed, the liquid in the first chamber is immediately detected. Therefore, in a preferred embodiment of the present invention, the first chamber 103 and the detection chamber 105 are in liquid communication, and the detection chamber includes a test element. In some preferred ways, these test elements are arranged on a carrier. In a preferred way, the detection chamber includes a test carrier 106, and there are many card slots 1061 on the test carrier, and each card slot is provided with a test element. For example, such as Fig. 9As shown, when collecting a liquid sample in the first chamber 103, a part of the liquid sample flows into the detection chamber 105 through the through hole 1038. The liquid sample flowing into the detection chamber contacts the test element, thereby completing the detection of the analyte; another part of the liquid sample flows into the second chamber 104 through the opening 1091 of the connection channel 109. When the test element in the detection chamber finishes the detection, the initial test result is read. After the reading, when it is considered necessary to perform a confirmatory secondary test, the second chamber 104 is separated from the first chamber 103, and then the opening 1042 of the second chamber 104 is sealed with the second cover 101, and the second chamber 104 is stored or directly sent to the laboratory structure for confirmatory testing for further confirmatory testing. The liquid in the first chamber 103 and the detection chamber 105 for the first detection can be discarded or processed.

[0156] By adopting the method of separating the first detection and the secondary confirmation detection, some drawbacks of traditional detection equipment are overcome. In traditional detection devices, after the test is completed, if a secondary test is required, the entire detection device (with a first chamber as the chamber for collecting liquid and / or with a detection chamber, or the test element in the detection chamber) needs to be stored, or the entire detection device needs to be packaged and transported (by land, sea or air) to a secondary testing institution for confirmation testing. This requires ensuring that no liquid sample leaks from any structure or anywhere in the entire detection device, because once the sample leaks, it will cause external pollution and the samples will also contaminate each other, resulting in uncertain results for the confirmation or secondary detection. This inevitably requires sealing every structure that may cause leakage, which increases the cost and design difficulty of manufacturing such a detection device. Since these primary detection devices are generally made of plastic and are disposable, it is relatively difficult to ensure that no liquid leakage occurs under any circumstances. Even if leakage can be guaranteed, the manufacturing cost is very high. Ideally, on the one hand, the cost should be reduced as much as possible, and on the other hand, the liquid sample should be ensured not to leak, which poses a great challenge to the manufacturer. For example, this requires a complex design of the first cover 102 that seals the opening 1031 of the first chamber to ensure that liquid cannot leak through the opening 1031. If the device also includes a test element, more precise processing or design is required for the chamber (if any) that houses the test element to ensure that the liquid sample cannot leak through the test chamber. In particular, these devices generally need to be transported by air and should not leak under negative or high pressure, which brings relatively great challenges to manufacturing and design. Traditionally, to avoid leakage, seals or silicone pads are always used as sealing components, but once the device is stored for a long time, these silicones or plastics will oxidize or age, causing liquid leakage during use. Second, if the sample of the primary detection result needs to be stored, more storage space is also required to accommodate the large-sized detection device; this will also inevitably increase more space. Especially for professional testing institutions, the number of samples to be tested is very large, and sufficient space is needed to store these samples that have undergone primary detection. These samples that have undergone primary detection are accommodated in relatively large detection devices, requiring a larger area or volume of storage space. Third, for these devices that have completed the primary detection, due to their large volume, the transportation cost is significantly increased, resulting in an increase in the cost of transportation packaging. After all, traditional detection devices are bulky and are individually packaged and transported. Fourth, if the detection device initially has a test element, during transportation, the collected liquid is always in contact with the test element, and the test element contains chemical substances that are not originally present in the liquid sample. Keeping the liquid sample in contact with the test element for a long time will cause contamination of the liquid sample, which may have a negative impact on subsequent secondary detection.In summary, for whatever reason, the conventional detection device or collection device has one or several of the defects described above.

[0157] When the device of the present invention is adopted, the volume of the second chamber is generally smaller than that of the first chamber, and even only one-tenth or a fraction of the conventional detection chamber. Generally, only 1-50 ml of the sample is required in the second chamber for secondary testing. For example, 0.1 ml, 0.2 ml, 0.3 ml, 0.4 ml, 0.5 ml, 0.6 ml, 0.7 ml, 0.8 ml, 0.9 ml, 1 ml, or only 1.2 ml, 1.4 ml, 1.6 ml, 1.8 ml, 2 ml, or only 3 ml, 4 ml, 5 ml, 6 ml is sufficient, 7 ml, 8 ml, 9 ml, 10 ml, 11 ml, 12 ml, 15 ml, 25 ml, 30 ml. The volume of the first chamber is generally 5-500 ml, for example, 8 ml, 10 ml, 12 ml, 14 ml, 16 ml, 18 ml, 20 ml, 22 ml, 24 ml, 26 ml, 28 ml, 30 ml, 32 ml, 34 ml, 36 ml, 38 ml, 40 ml, 42 ml, 44 ml, 46 ml, 48 ml, 50 ml, 60 ml, 70 ml, 80 ml, 100 ml, 150 ml, 200 ml, 250 ml, 500 ml. Moreover, generally, the second chamber has only one opening 1042, and as long as the second opening 1042 is sealed well, it can be confirmed that the sample will not leak. On the one hand, the small volume and light weight of the second chamber significantly reduce the transportation and packaging costs and the storage space is very small. On the other hand, there is no need to have as high a sealing requirement for the first chamber and / or the component containing the detection chamber as the conventional device. For example, the sealing requirement for the first cover to seal the opening 1031 of the first chamber is much lower, and the sealing requirement for the detection chamber provided with the test element is also much lower than that of the conventional one. Even the sealing effect of the first cover on the opening of the first chamber 103 can be ignored, and the sealing effect of the detection chamber itself can also be ignored because once the primary detection is completed, the first chamber 103 and / or the first chamber with the test chamber 105, and even the first cover 102 can be discarded. Compared with the conventional disposable detection device, a large amount of cost is saved and it is safer and more reliable. In addition, since the nature of the liquid in the second chamber is the same as that of the first chamber, the effectiveness of the secondary detection is ensured. Third, due to the small volume of the second chamber, there is no need to specifically consider the storage space. A large number of second chambers can be stored in a very small place, reducing the pressure on the confirmation laboratory and also reducing the transportation cost, while ensuring the safety of transportation because there is no need to worry too much about the risk of liquid leakage.

[0158] In some preferred embodiments, when the liquid sample collected in the first cavity 103 needs to be tested and the secondary confirmation sample needs to be collected in the second cavity 104 at the same time, it is hoped that the sample flowing into the detection cavity (if there is a detection cavity) will not cause potential contamination to the liquid sample entering the second cavity 104, so that the position of the opening 1091 of the connecting channel 109 is higher than the height of the through hole 1038 (for example Figure 7 and Figure 6 As shown, Fig. 9 As shown in the figure, the liquid flowing into the detection chamber will not or can hardly enter the second chamber, thereby ensuring that the liquid in the second chamber 104 is substantially the same as the liquid sample that has not been in contact with the test element. After all, the liquid sample in contact with the test element may contain some chemical reagents or other components that have been processed on the test element. If such reagents or components enter the second chamber, it may have an adverse effect on the second test result. It can be understood that the opening 1091 with the connecting channel is higher than the through hole 1038, or according to the aforementioned method, the opening through which the liquid flowing into the second chamber passes is higher than the position of the through hole flowing into the detection chamber (for example, the bottom hole in the aforementioned embodiment, which does not have a connecting channel at this time), which can prevent the liquid sample in contact with the test strip from entering the second chamber when the test element is included in the device and in contact with the liquid sample.

[0159] In some preferred embodiments, the first cavity contains a collection area 1035 or 1036 for collecting liquid, and these collection areas are located at the bottom of the first cavity 103, around the connection channel 109 or around the first opening 1091 of the connection channel. In some preferred embodiments, the positions of these collection areas are lower than the positions of the connection channel opening 1091, so that when the liquid enters the first cavity, it first collects in the collection area, and then enters the detection cavity through the through hole 1038 to contact the test element. Therefore, according to the order in which the liquid arrives, the liquid first arrives in the collection area, then flows into the through hole 1038 to enter the detection cavity (if any), and then reaches the position of the first opening 1091 of the connection channel.

[0160] In some preferred embodiments, for example, Fig.12 , Figure 4 , Figure 5 As shown, there is a raised area in the middle of the bottom of the first cavity, and the space formed by the raised area is used to accommodate part of the main structure of the second cavity 104. A connecting channel or hole is set on the raised area, and the raised area also forms a collection area u( Figure 4 and Figure 5 As shown) from the bottom of the first cavity (eg Figure 4), the bottom is recessed into the first cavity 103, and this recessed area is used to accommodate a part of the area including the opening 1042 of the second cavity 104. In this way, overall, it will not add extra materials to the detection device and will not look obtrusive. As Figure 7-Figure 11 described, the opening part of the second cavity is provided under the bottom of the first cavity 103. Overall, it is still similar to the traditional detection device. In some preferred ways, the positions of the collection areas 1036 and 1035 are lower than the position of the through hole 1038. In this way, the collected liquid sample first enters the detection cavity (if any) 105 through the through hole 1038. As long as the detection cavity is filled or the liquid seals the through hole 1038, the excess liquid will enter the second cavity 104 through the first opening 1091 of the connection channel 109. In this way, it is possible to avoid as much as possible the liquid flowing into the detection cavity from coming out of the detection cavity and entering the second cavity. Or, in terms of the order of liquid flow, the liquid generally first reaches the collection area for collection. After collecting to a certain height, it flows into the detection cavity through the through hole 1038 for testing. After the detection cavity collects the liquid sample, the through hole 1038 will be sealed by the liquid. As the liquid increases, the liquid level will reach the position of the connection channel opening 1091, and then enter the second cavity, filling the second cavity or part of the liquid sample enters the second cavity for subsequent secondary confirmation testing.

[0161] In some other ways, the detection device does not separately contain a test cavity (as Figure 1 shown), for example, as Figure 15-17 such, on the side wall in the first cavity 203, there is an area. For example, as Fig.16 shown, there are two vertical clamping strips 2032 and 2033 in the first cavity 203. The two clamping strips limit such an area, allowing a carrier as Fig.17 shown to be inserted into this area to form a structure with test functions. For example, as Fig.17The carrier structure is provided with a plurality of channels 2063 for accommodating test elements. One end 2062 of the channel is closed and the other end is open 2061. Each channel is arranged on the carrier in such a compatible direction. The detection area and water absorption area on the test element are located in the channel, and the sample application area on the test element is located at one end of the channel opening 2063. The test elements in each channel are arranged in such a way that the sample application area of ​​the test element in each channel is located at the end 2065 of the carrier, and correspondingly, the detection area of ​​the test element is located at the end close to the channel seal, that is, at the top 2064 of the carrier. When the carrier is assembled into the first cavity 103, the end 2065 of the carrier is close to the bottom 2034 of the first cavity, and the top 2064 of the carrier is close to the opening 2031 of the first cavity. In this way, part of the liquid sample entering from the opening of the first cavity 203 contacts the sample application area of ​​the test element near the bottom 2034 of the first cavity 203, thereby completing the test and analysis of the analyzed substance in the liquid sample. In some other preferred embodiments, for example Figure 25-Figure 30 As shown, the second cavity 304 and the first cavity 303 can be combined in a detachable manner in the same manner as described above, for example, Figure 1 , Figure 6-Figure 13 or any of the aforementioned methods, including any subsequent methods for sealing or separation.

[0162] In some preferred embodiments, the bottom 2034 of the first cavity has a groove 2035 structure, and the groove structure 2035 allows the liquid sample to be collected in the first cavity, such as Fig. 22 and Fig.23 As shown. In some preferred embodiments, the height of the first opening 2091 of the connecting channel 209 is higher than the height of the groove, that is, the opening 2091 of the connecting channel 2091 is located upstream of the groove 2035, so that the liquid sample in contact with the test element and near the groove can be prevented from flowing into the second cavity 204 through the first opening 2091 of the connecting channel 209. Similarly, when the test element in the carrier located in the first cavity completes the initial or first test, when it is considered necessary to perform a subsequent secondary confirmation test, the second cavity can be directly separated from the first cavity. After separation, the opening 2041 of the second cavity 204 is sealed with the second cover 201 for separate storage, or it is separately packaged and transported to the second confirmation test structure for confirmation test. Correspondingly, the carrier 206 that has completed the initial test and the first cavity 203 with the carrier and the first cover 202 with the opening 2031 that seals the first cavity 203 are discarded or processed together. The volume of the first cavity is generally larger than that of the second cavity. They may also be designed based on the volume difference as described above. Of course, the volume of the first cavity may be equal to that of the second cavity. Optionally, the volume of the first cavity may be smaller than that of the second cavity.

[0163] In some ways, there are no particular restrictions on the shape of the first cavity and the shape of the second cavity. For example, generally, the shape of the first cavity is cylindrical, while the shape of the second cavity is cylindrical. Of course, the shape of the first cavity can be a cuboid, a cube, an ellipsoid or a cone. Correspondingly, the shape of the second cavity can be a cuboid, a cube, an ellipsoid or a cone.

[0164] The detachable ways of the first cavity and the second cavity have been described above. Generally, the second cavity is located inside or at the bottom of the first cavity. Or, initially, the first cavity and the first cavity are combined together. Generally, after collecting the liquid, the first cavity and the second cavity are separated. Of course, the specific position of the second cavity is not limited, and the second cavity can also be in other ways.

[0165] Sealing elements

[0166] In some preferred ways, when the first cavity is separated from the second cavity or just before separation or before staging, the first cavity and the second cavity that were originally in a liquid flow state are made not to be in a liquid flow state, so as to prevent the liquid from flowing between the first cavity and the second cavity. Or, there are the following several states regarding whether the first cavity and the second cavity are connected to the liquid: The first state is that the liquid is not connected, and the second state is that the liquid is connected; or, the first state is that the liquid is connected, and the second state is that the liquid is not connected. As for the different states of the second cavity and the second cavity in different purposes or operation processes, whether it is in a liquid-connected or non-liquid-connected state can be arbitrarily designed and selected. For example, when the first cavity collects a fluid sample or a liquid sample, the first cavity and the second are in a liquid flow state; when separation is needed or during separation, the second cavity is made not to be in a liquid flow state with the first cavity. Or, when the first cavity collects a fluid sample or a liquid sample, the first cavity and the second are not in a liquid flow state; when separation is needed or during separation, the second cavity is made not to be in a liquid flow state with the first cavity, so that the second cavity collects the liquid from the first cavity, and then the first cavity and the second are made not to be in a liquid flow state, so as to separate the second cavity and detach it from the first cavity.

[0167] Thus, in some embodiments, a sealing element is provided. When the first chamber 103 is detachably combined with the second chamber 104 through the connecting channel 109, the sealing element seals the connecting channel, preventing the liquid in the first chamber from entering the second chamber again, or preventing the liquid in the first chamber from flowing out through the channel for the liquid entering the second chamber. The so-called prevention of liquid from flowing out through the connecting channel means sealing the connecting channel or substantially sealing the connection between the first chamber and the second chamber. This connection can be indirectly connected through the connecting channel or can be connected without passing through the connecting channel. In any case, in these embodiments, after, during, or before separating the second chamber from the first chamber, the connection between the first chamber and the second chamber is liquid-sealed, thus preventing the liquid from entering the second chamber, or preventing the liquid sample from leaking to the external environment of the first chamber after the separation of the second chamber. In some preferred embodiments, the liquid cannot leak through the connection to the external environment of the first chamber containing the detection chamber, or the liquid cannot leak through the connection to the external environment of the first chamber containing the test element. It can be easily understood that when the connection and liquid flow are not achieved through the "connecting channel" which is the preferred embodiment of the present invention, but through two independent structures, namely the connection structure and the flow channel, once the first chamber and the second chamber are separated through the connection structure, the liquid flow can be achieved by sealing the flow channel with a sealing element. Therefore, the function of the sealing element is to make the first chamber and the second chamber not in a liquid flow state, changing from the liquid flow state to the liquid non-flow state.

[0168] In some preferred embodiments, when the second chamber is detachably connected to the first chamber through the connecting channel, before, after, or during the separation of the second chamber from the first chamber, the connecting channel is sealed by a sealing element. The sealing element can seal the first opening 1091 of the connecting channel, such as Fig.12As described above. Here, the sealing element, like a plug, blocks the opening 1091 of the connecting channel, thus preventing liquid from entering the second chamber or flowing out of the first opening 1091 of the connecting channel into the outside of the first chamber. The sealing element here can match or adapt to the shape of the opening of the connecting channel to seal the connecting channel. The so-called adaptation means that the sealing element and the connecting channel cooperate with each other through one or a combination of appropriate dimensions, appropriate materials, and appropriate shapes to achieve liquid sealing. For example, the first opening of the connecting channel is circular, and the sealing element is also circular. Or, the connecting channel is made of plastic, and the sealing element is also made of plastic, relying on the mechanical elasticity inherent in the material itself for sealing. Or, the sealing element is rigid, and the connecting channel is elastic. Or, both the sealing element and the connecting channel are rigid. These methods can all achieve the sealing effect and thus realize the functions described above. For example, the sealing element is elastically deformable, and the connecting channel is rigid. The sealing element is inserted into the connecting channel to seal the opening of the connecting channel. This sealing method can be arbitrarily selected. The sealing element can be used alone to seal the connecting channel or the place where the liquid flows between the first chamber and the second chamber, enabling the liquid in the first chamber and the second chamber to communicate with each other.

[0169] In some preferred embodiments, the first cover 102 includes the sealing element for sealing the connecting channel. When the first cover closes the opening of the first chamber, the sealing element seals the opening of the connecting channel. In fact, the sealing element and the cover form a linkage mechanism, and the movement of the cover drives the movement of the sealing element. The movement of the first cover is to seal the opening of the first chamber. If the first cover moves, it can also cause the sealing element to seal the connecting channel at the same time, which is more convenient in operation. Of course, it can be understood that the closing of the first cover on the first chamber and the sealing of the connecting channel by the sealing element are not necessarily linked and can be completed in two steps, which also falls within the scope of the present invention. Preferably, the sealing element seals the first opening of the connecting channel. In other words, the movement of the first cover and the change in the state of enabling the liquid in the first chamber and the second chamber to communicate with each other are completed in a linked manner. For example, during the movement of the first cover, the first chamber and the second chamber that are in a liquid communication state are changed to a state where the first chamber and the second chamber are not in a liquid communication state. Or, the movement of the first cover changes the state where the first chamber and the second chamber are not in a liquid communication state to a state where the first chamber and the second chamber are in a liquid communication state, and then, with the movement, changes back to a state where the first chamber and the second chamber are not in a liquid communication state.

[0170] The covering here can refer to the cover body where the first cover body cooperates with the first cavity to cover the opening 1031 of the first cavity. Of course, it can also be that the cover body seals the opening 1031 of the first cavity 103. The sealing here can be just ordinary sealing, or it can also be in a non-sealed state, just to prevent the liquid sample from spilling out of the first cavity. For example, when moving the first cavity, to avoid the liquid overflowing from the opening 1031 of the first cavity. As described before, the covering of the first cover body and the opening of the first cavity does not require the same sealing effect as that of traditional detection devices because there is no need to transport the entire detection device or transport it under some extreme conditions. The sealing element is on the cover body. When the first cavity has collected enough liquid, generally the cover body needs to cover the opening of the first cavity. When the cover body covers the opening 1031 of the first cavity, the sealing element connected to the cover body simultaneously seals the opening of the connection channel or the connection channel, so as to prevent the liquid from entering the second cavity. When the second cavity is separated from the first cavity, the liquid cannot leak to the outside through the connection channel. This makes the operation more convenient, simple and fast, completing two functions in one step of operation. The sealing effect of the sealing element sealing the connection channel here can only be to temporarily prevent the liquid from leaking to the outside through the connection channel, and does not require the same sealing effect as that of traditional detection devices to ensure no leakage under extreme transportation conditions (such as high pressure or vacuum). This is also because the sample in the second cavity is used as a transportation carrier for secondary confirmation testing, while the liquid in the first cavity does not need to be transported or stored and can be discarded later. Therefore, the sealing of the opening 1031 of the first cavity and the connection channel or the opening 1091 of the connection channel here is only general sealing, and does not need to be in a sealed state under negative pressure or vacuum as in traditional devices. The main reason is that there is no need to transport the liquid in the first cavity through the first cavity to a professional laboratory or testing institution for secondary testing.

[0171] For convenience and low production cost, both the first chamber and the second chamber are made of plastic, which are injection-molded in one piece. The sealing element and the first cover are also injection-molded. Depending on the physical properties of the plastic materials, the sealing element can seal the connection between the first chamber and the second chamber. Preferably, it seals the connection channel between the first chamber and the second chamber. To achieve a better sealing effect, an elastic sealing ring 108, such as an "O"-ring, such as a silicone sealing ring, can be provided on the sealing element. These sealing rings are flexible relative to the material of the sealing element. Thus, when the sealing element seals the first opening 1091 of the connection channel, its sealing effect is enhanced. It can be understood that when the cover and the sealing element need to be linked, usually the first cover and the opening of the first chamber are joined together by threads. The first cover covers the opening of the first chamber in a rotational manner, and the sealing element also enters the connection channel or seals the opening of the connection channel in a rotational manner, or seals the hole for the liquid communication between the first chamber and the second chamber (if the connection channel is omitted).

[0172] It can be understood that the "O"-ring and the sealing element are used in combination. The "O"-ring can be produced separately and then assembled onto the sealing element, which has a sealing function. Of course, the structure of the "O"-ring and the position for installing the "O"-ring can be made of the same material and completed by injection molding in one piece. In this way, the production and processing technology are facilitated. Of course, in other cases, the "O"-ring can also be omitted, and the sealing can be achieved only by the different materials of the connection channel and the sealing element.

[0173] In some preferred ways, when the sealing element and the first cover are connected, they can be injection-molded in one piece or connected to the cover in a detachable manner. For example, as Figure 2 and Figure 3 shown, a sealing element 1028 is connected to the first cover. A sealing ring 108 is provided on the sealing element, and the sealing element and the cover 102 are of an integral structure. To better fix the sealing ring, a groove structure is provided on the sealing element to elastically fix the sealing element on the groove. Generally, the first chamber needs to accommodate a certain volume of liquid sample, so it has a certain volume. Therefore, there is a certain distance between the opening 1031 of the first chamber and the first opening 1091 of the connection channel at the bottom of the first chamber. Therefore, the sealing element is connected to the cover 102 through the connection structure 1023 to form an integral structure. As Fig.12As shown, when the cover is attached to the opening 1031 of the first chamber, for example, by rotation, the sealing element 1028 integrated with the cover also rotates into the connection channel 109. Along with the attachment process of the cover, the sealing element enters the connection channel, so that the sealing element 1028 seals an opening 1091 of the connection channel, thus preventing the liquid sample from entering the first chamber. When the second chamber is separated from the first chamber, the liquid sample in the first chamber will not leak to the outside through the connection channel.

[0174] For example, as Fig. 22 shown, a connection structure 2023 is connected to the first cover 202, and the connection structure 2023 extends for a section to serve as a sealing element 2028 to seal the connection channel; in Fig. 22 the state shown, at this time when the sealing element 2028 (the part with the sealing ring 208) has not approached the opening 2091, the first chamber and the second chamber are in a liquid flow state. As the position of the cover changes, the sealing element approaches the position of the opening 2091. With the movement, the sealing element seals the opening 2091, and at this time the sealing effect is achieved, and the liquid in the first chamber will not flow into the second chamber.

[0175] It is a preferred way to adopt the method of linkage between the cover and the sealing element, so that the first chamber and the second chamber are not in a liquid communication state. Of course, the cover and the sealing element can be integrally injection-molded, or can be injection-molded and assembled together multiple times. For example, the cover is integrally injection-molded, and the connecting rod 2023 and the sealing element 2028 are integrally injection-molded; then they are combined together by any optional plugging, threading or other means, so that the movement of the cover drives the sealing element to move together, which is called "linkage". In another way, the sealing element, the connecting rod and the cover are injection-molded separately and then assembled together is also possible.

[0176] Therefore, in some preferred ways, the sealing element is also detachably connected to the cover. For example, as Figure 31-Figure 35As shown, the cover 402 includes a sealing element 4028, whose shape matches that of the connection channel or the first openings 1091, 3091, such as the shape of a piston. In this way, a part of the connection structure 4023 is used as the sealing element 4028, and there is no sealing ring at this time. However, the materials can be different. Generally, the material of the sealing element is more elastic. In this way, even without a sealing ring, the elastic sealing element is easier to seal the connection channel or the first opening of the connection channel. For example, the sealing element can be made of latex, silicone, or other elastic materials. Or, the sealing element is composed of two parts. The inside is made of a relatively hard material, and a layer of elastic materials such as silicone, rubber, or latex is covered on the surface of the hard material to enhance the sealing effect between the sealing element and the connection channel or the opening of the opening 1091. At the same time, when the first cover 402 covers the opening of the first cavity 103, 203, less force is required to make the sealing element 4028 seal the connection channel or the opening. For example, the sealing element can be made to enter the connection channel to seal the connection channel. Or, the sealing element 5029 (when the structure of 5029 is used as the sealing element) is threadedly connected to the connecting rod 5023. For example Figure 33-Figure 34 , in this embodiment, an external thread is provided at one end 5030 of the sealing element 5029, and an internal thread is provided at one end of the connection structure 5023. The sealing element is integrally connected to the cover in a threaded form. In this way, the sealing element can have different materials from the cover and the connection structure, and the sealing element has more design forms and methods to meet different sealing needs.

[0177] The sealing here may be a separate component or be provided at the connection between the second cavity and the first cavity, which can block the liquid flow between the second cavity and the first cavity. The flow here is generally active. In fact, when the liquid flows passively from the second cavity to the first cavity, the sealing element is not necessary.

[0178] Also, as mentioned before in combination with Fig. 27 When there is no connection channel structure provided between the first cavity and the second cavity, in fact, there is only a hole, such as the hole 3091, and the part 3098 where the connection channel extends is missing. At this time, the sealing element only needs to seal the opening 3091, and there is no need to make the sealing element enter the connection channel. For example, the sealing element is like a rubber stopper, which is provided on the connecting rod 3023 of the cover. The linkage of the cover drives the stopper to block the opening 3091, realizing the change of the liquid flow state between the first cavity and the second cavity.

[0179] Furthermore, the sealing element can seal the first opening of the connection channel from the beginning. After the first chamber 103 has collected the liquid sample, or before or after the initial detection of the liquid sample in the first chamber, the piercing element is used to pierce the sealing element or remove the sealing element, allowing the liquid sample to flow into the connection channel and enter the second chamber 104 through the second opening. Moreover, the second chamber and the first chamber are detachably combined, so that the second chamber can be separated from the first chamber for subsequent possible confirmation tests. Therefore, when the sealing element is pierced, the sealing element here can be a pierceable structure. For example, this kind of sealing element can be an adhesive tape, double-sided tape, plastic sheet, etc. Generally, the pierceable element does not allow liquid to enter the connection channel at the beginning, but only after being pierced. There are many ways to pierce it, such as using a sharp object to pierce. In some ways, the piercing element can be arranged on the first cover 102, and there is a linkage piercing structure in the cover. When the first cover closes the opening of the first chamber 103, the piercing element pierces the sealing element, allowing the liquid to flow from the first chamber to the second chamber. If it is necessary to separate the first chamber and the second chamber, before separation, another sealing element is used to seal the piercing point, thus realizing the change of the liquid flow state between the first chamber and the second chamber.

[0180] For example, as Figure 39-40 shown in the schematic diagram, the first chamber 702 includes an opening 7031 for receiving the liquid sample. There is a hole in the first chamber, which is the first opening 7091 of the connection channel. This opening is sealed by a pierceable sealing element 70281, and the detection chamber 705 in liquid communication with the first chamber is in liquid communication through the channel 7038. And Figure 37-Figure 38 is different in that the first cavity is used as a cavity for collecting liquid samples for the initial detection, and the second cavity 704 is detachably connected at the second opening 7092 of the connecting channel. When the liquid sample is collected, the liquid part of the first cavity flows into the detection cavity for the initial test, and then the opening of the first cavity is covered with the first cover body, the cover body is provided with the second cover body, and the first cover body is provided with a sealing element 7028 and a piercing element 7029. In this way, the cover body, the sealing element 7028 and the piercing element 7029 form a linkage mechanism, so that when the first cover body covers the first cavity, the sealing element and the piercing element are driven to be linked, and the piercing element currently pierces the seal of the first opening of the sealing connecting channel, and then releases the liquid into the second cavity, and then the opening of the second cavity is sealed with the seal. Of course, the piercing element can also have the function of removing part of the liquid from the second cavity. At this time, the piercing element can also have a liquid-repelling channel, a liquid inlet and a receiving cavity. In this way, after piercing the first opening 7091 of the sealed connection channel, the piercing element is directly partially inserted into the second cavity. In order to allow the liquid to be discharged, the liquid can flow into the receiving cavity through the liquid inlet of the liquid-repellent channel. For example, the receiving cavity is located in the piercing element. This can be clearly understood and combined with the detailed description below. Fig.40 As shown in the figure above, when a secondary confirmation test is required, the second cavity is removed from the first cavity, for example, by rotating the thread, and then the opening 7041 of the second cavity 704 is sealed with the second cover to perform a subsequent secondary confirmation test.

[0181] In summary, allowing the liquid to flow from the first cavity to the second cavity can mean that when the liquid enters the first cavity, it can also flow to the second cavity, or after the liquid sample flows into the second cavity, the liquid does not enter the second cavity at the same time or immediately. This is because the second cavity is not in liquid communication with the first cavity, but at any time thereafter, the second cavity is in liquid communication with the first cavity. The way of not being in liquid communication and being in liquid communication is a matter of controlling the timing of the sealing element. For example, puncturing the sealing element on the first opening 1091 or the second opening 1092 of the sealing connection channel is a way to connect the two cavities. Of course, in order to separate the second cavity and prevent the liquid in the first cavity from continuing to flow into the second cavity, sealing is also required after puncturing.

[0182] Therefore, in some ways, when the first chamber 104 is not used to collect a liquid sample, the second chamber and the first chamber are in liquid communication. When collecting the liquid or after the liquid sample collection is completed, the second chamber and the first chamber are not in liquid communication. Of course, optionally, when the first chamber 104 is not used to collect a liquid sample, the second chamber and the first chamber are not in liquid communication. When collecting the liquid or after the liquid sample collection is completed, the second chamber and the first chamber are in liquid communication. When the liquid sample enters the second chamber or afterwards, before the first chamber and the second chamber need to be separated, the second chamber and the first chamber are again not in liquid communication. In the above ways, the sealing element plays different functions at different times. When to seal and when not to seal can be selected according to the appropriate timing.

[0183] In the above examples that require a sealing element, the liquid sample can always freely flow from the first chamber 103 to the second chamber (for example, under the action of gravity, the liquid always flows from a higher position to a lower position). To avoid continued flow after separating the two chambers, a sealing element is used; however, in reality, when the liquid sample passively overcomes gravity and flows from a lower position to a higher position, a sealing element is not necessarily required. For example, in the example of Design 3, a separate sealing element is not needed.

[0184] Liquid-repellent channel

[0185] The "liquid drainage channel" mentioned here is similar to a liquid discharge channel. Through this channel, the liquid is drained or discharged, and it can also be considered as a channel that allows the liquid to flow from one place to another through this channel. In addition, the "liquid drainage channel" here can also remove excess gas, thereby relieving the pressure; through this channel, the gas is drained or discharged, and it can also be considered as a channel that allows the gas to flow from one place to another through this channel. Therefore, the "liquid drainage channel" here can remove excess liquid, or excess gas, or a mixture of gas and liquid. The so-called "channel" generally means, for example, in the shape of a tube, for example, enclosed on all sides and including two openings. One opening can be used as a liquid inlet, and the other opening can be used as a liquid outlet; or, one opening can be used as a gas inlet, and the other opening can be used as a gas outlet; or, one opening can be used as an inlet for a mixture of liquid and gas, and the other opening can be used as an outlet for discharging the mixture of liquid and gas. One inlet and one outlet here are just one implementation manner. Of course, it can contain one or more inlets, and can also include one or more outlets. There is no limit to the length of the channel itself. It can be relatively long or relatively short, which can be easily achieved by those of ordinary skill in the art according to the actual situation.

[0186] In some more preferred embodiments, if sealing can be achieved simply by sealing the hole between the first chamber and the second chamber, however, if a better sealing effect is desired, for example, when connecting the first chamber and the second chamber using a connection channel, the connection channel generally has an extension section 3094, and this extension section is at Fig. 27It extends into the opening of the second chamber. Of course, it can also extend a certain distance or length into the first chamber at the connection channel 3091. To achieve a better sealing effect, a plug-like sealing element generally needs to be partially inserted into the connection channel to seal the connection channel. Generally, before sealing the connection channel, the connection channel contains a liquid sample, and the second chamber is also filled with the liquid sample. This is because the collected liquid sample needs to meet the requirements of secondary confirmation testing and the initial testing of the test element, and the liquid sample still needs a sufficient volume. Therefore, in some preferred ways, the height of the liquid level in the first chamber is higher than the position of the first opening of the connection channel, that is, the first opening of the connection channel is below the liquid level, so that the connection channel and the second chamber are both filled with liquid. In this case, to make the sealing element partially enter the connection channel to achieve a better sealing effect, this liquid seal prevents the liquid sample from leaking from the first chamber to the outside after the second chamber is separated from the first chamber. In this case, it is difficult for the sealing element to enter the connection channel because although the sealing element has a similar size to the connection channel, when sealing the connection channel 109, it is necessary to overcome a certain reaction force of the liquid acting on the sealing element. This is because, to achieve a better sealing effect, the sealing element needs to enter a part of the connection channel to obtain a better seal. To obtain a better seal, in the presence of the connection channel, the sealing process is a dynamic process. From the sealing element starting to approach the first opening of the connection channel (the first state), to the sealing element completely blocking the first opening of the connection channel (the second state, at this time it is okay and can play a sealing role), and then to the sealing element entering the connection channel (the third state, achieving the third state means obtaining a better sealing effect). During this process, when changing from the second state to the third state, it is actually necessary to overcome the reaction force of the liquid sample in contact with the sealing element in the connection channel. Especially when the sealing element enters the connection channel, it needs to compress the liquid in the connection channel. If the liquid cannot be discharged, it is very difficult for the sealing element to change from the second state to the third state. The distance from the first opening of the sealed connection channel to entering the connection channel can be 0.1 - 10 millimeters, or even a farther distance, so as to ensure a better sealing effect. For example, the distance that the sealing element enters the connection channel is 0.1 millimeter, 0.2 millimeters, 0.3 millimeters, 0.4 millimeters, 0.5 millimeters, 0.6 millimeters, 0.7 millimeters, 0.8 millimeters, 0.9 millimeters, 1 millimeter, 2 millimeters, 3 millimeters, 4 millimeters, 5 millimeters, 6 millimeters, or 7 - 10 millimeters. To reduce this reaction force of the liquid, which is the pressure exerted by the liquid on the sealing element, it is necessary to smoothly discharge the volume of liquid displaced by the sealing element to another place, so as to reduce the reaction pressure borne by the sealing element, and thus make it easier for the sealing element to enter the connection channel.Therefore, when the sealing element enters the connection channel, it is necessary to displace a portion of the liquid volume within the connection channel to allow the sealing element to smoothly enter the connection channel, thereby smoothly sealing the connection channel or the opening of the connection channel. This is similar to the principle of inserting a bottle cork into the opening of a bottle. If the bottle is filled with water, it is very difficult to insert the cork. It is necessary to pour out some of the water or liquid in the bottle so that the cork can be inserted into the bottle mouth to seal the opening of the bottle. However, when the second chamber is filled with liquid and the connection channel is also filled with liquid, sometimes the first opening of the connection channel is located below the liquid level in the first chamber. It is necessary for the sealing element to enter or the sealing element to seal the opening of the connection channel in the form of a piston. This requires displacing a portion of the liquid in the connection channel to another place to facilitate the entry of the sealing element into the connection channel. The best way is to displace some liquid when entering. The entry of the sealing element is forced by an external force into the connection channel.

[0187] Therefore, in some preferred embodiments, the device further includes a liquid drainage channel through which the squeezed liquid generated in the connection channel when the sealing element enters can be discharged outside the connection channel, thereby allowing the sealing element to smoothly enter the connection channel. For example, in some preferred embodiments, the liquid inlet of the liquid drainage channel is located on the sealing element. As the sealing element enters the connection channel, the excess liquid enters the liquid drainage channel through the liquid inlet and is thus discharged outside the connection channel. Generally, the outside of the liquid drainage channel mentioned here can be a place other than the connection channel and the second chamber that is detachably connected to the connection channel, such as a receiving chamber, such as in the first chamber, or in the detection chamber, or other places. Therefore, the device further includes a receiving chamber for receiving the liquid or gas from the liquid drainage channel. Generally, the sealing element seals the connection channel or blocks the liquid flow between the first chamber and the second chamber, generally divided into two states. First, before the sealing element seals the connection channel, the first chamber and the second chamber are in communication, and at this time, the liquid can be exchanged between the two chambers. Generally, the liquid can naturally flow from the first chamber to the second chamber. Second, when the sealing element starts to seal the connection channel, such as the opening of the connection channel, the first chamber and the second chamber are not in communication. Due to the continuous entry of the sealing element into the connection channel, the pressure in the connection channel and the second chamber will increase. Due to the pressure, the liquid in the connection channel and the second chamber will enter the receiving chamber through the liquid inlet of the liquid drainage channel to reduce the pressure of the former, thereby allowing the sealing element to smoothly seal the connection channel. Of course, the liquid drainage channel here can be arranged arbitrarily. Generally, the liquid drainage channel is in liquid communication with the receiving chamber. In this way, if the liquid discharged when the sealing element continues to enter the connection channel enters the receiving chamber through the liquid drainage channel.

[0188] In some embodiments, such as Figure 3 and Figure 2As shown, the sealing element 1028 is used to seal the opening 1091 of the connection channel 109, and the receiving cavity can be located within the sealing element. For example, the sealing element has a hollow structure, so that the excluded liquid can enter the receiving cavity, and the hollow structure 1029 can be used as the receiving cavity. For example, as Figure 3 shown, the sealing element 1028 also includes a receiving cavity 1029. When the sealing element enters the connection channel, the excess liquid enters the receiving cavity 1029 through the liquid drainage channel 1025, thereby reducing the pressure. Of course, the liquid drainage channel 1025 here is very short because the sealing element is a thin-walled structure or a hollow structure. Of course, it is easy to understand that the receiving cavity does not necessarily have to be located on the sealing element. When the connecting rod structure 1023 is a hollow structure 1030, the hollow structure 1030 communicates with the receiving cavity 1029 to form a large receiving cavity to receive the volume of liquid excluded by the sealing element, or the hollow structure 1030 can be used as the receiving cavity, with the same effect. In some preferred ways, for example, as Figure 2-Figure 3 , Fig.12 shown, the sealing element 1028 seals the opening of the connection channel 1091 and enters the connection channel 109, and the excess liquid enters the receiving cavity 1029 through the liquid drainage channel 1025. In such an embodiment, one end opening (liquid inlet) of the liquid drainage channel communicates with the liquid in the connection channel, and the liquid at the other end opening (liquid outlet) communicates with the liquid in the receiving cavity, so that the liquid can enter the receiving cavity. Here, since the liquid drainage channel is provided on the hollow sealing element, the liquid drainage channel is very short. No matter how short it is, there is always a liquid inlet and a liquid outlet. In fact, when the receiving cavity is located in the sealing element or the subsequent liquid drainage element, there is actually no strict division between the liquid inlet and the liquid outlet. Only when the liquid drainage channel is relatively long, there is a division of the positions of the liquid inlet and the liquid outlet. This is because the sealing element or the liquid drainage element is a hollow structure and the wall is very thin. Actually, when a hole is opened in the wall, this hole plays the role of allowing the liquid to enter the receiving cavity. At this time, there is no necessary position division for the liquid inlet or the liquid outlet. This hole can also be called the liquid inlet or the liquid outlet. In short, the position division is not very obvious.

[0189] In some preferred ways, as Fig.12 shown, the liquid inlet of the liquid drainage channel is located below the sealing element. In some preferred ways, the liquid inlet of the liquid drainage channel is located on the sealing element and enters the connection channel earlier than the sealing element, so as to drain the excess liquid out of the connection channel, thereby reducing the reaction resistance of the liquid level borne by the sealing element. The liquid drainage channel here can refer to the through hole on the receiving cavity 1029. Such a liquid drainage channel can be one or more.

[0190] In a preferred embodiment, the liquid inlet of the liquid drainage channel enters the connection channel before the sealing element. Therefore, in some cases, if the liquid drainage channel is relatively long and the first chamber is used as a receiving chamber, the liquid inlet of the liquid drainage channel is located on the sealing element but enters the connection channel before the sealing element. In this way, as the sealing element enters the connection channel, the liquid discharged enters the liquid drainage channel through the liquid inlet of the liquid drainage channel and then reaches the first chamber or the receiving chamber through the liquid outlet of the liquid drainage channel. Here, the first chamber is a specific form of the receiving chamber, and the first chamber can also be a chamber with the function of a receiving chamber. Therefore, the receiving chamber is not necessarily located on the sealing element. The best way is to be located on the sealing element or in the connecting rod that connects the sealing element to the cover body. In this way, as the sealing element enters the connection channel, the excess liquid is discharged outside the connection channel through the liquid inlet of the liquid drainage channel. This discharge is the liquid forced out due to the pressure on the liquid surface generated by the sealing element entering the connection channel. Of course, the size of the receiving chamber is related to the discharged liquid. Just set an appropriate volume capacity to accommodate the discharged liquid.

[0191] Regarding the positional relationship of the "liquid inlet of the liquid drainage channel", if the sealing element needs to enter the connection channel, it will compress the liquid sample in the connection channel. In this case, the position of the liquid inlet should be below the sealing element. The so-called "below" is only in terms of relative position and does not necessarily mean on the sealing element. For example, it can be located on the wall of the connection channel. When the sealing element enters the connection channel, at this time, the liquid inlet on the wall of the connection channel is relatively below the sealing element. As the sealing element continues to enter the connection channel, part of the liquid is forced into the liquid inlet and discharged, so that the sealing element can enter smoothly. In one case, the sealing element can continue to enter the connection channel until the sealing element and the liquid inlet on the wall of the connection channel overlap, and the liquid can no longer enter the liquid drainage channel through the liquid inlet and is thus discharged outside the connection channel. Therefore, in some preferred ways, the liquid inlet is located below the sealing element. For example Figure 2-Figure 3 as shown, a liquid inlet 1032 is provided below the position of the sealing element 1028, and this liquid inlet is the liquid inlet of the liquid drainage channel 1025.

[0192] For another example, Fig.15 , Fig.18 , Fig. 22 , Fig.23 , Fig. 27 as shown. For example, as Figure 15-Figure 24As shown, the sealing element 2024 and the connection structure 2023 are an integral structure. The extended part of the connection structure serves as the sealing element, and the entire connection structure and the extended structure are hollow structures 2030, 2029. The hollow structure is used as a large receiving cavity. The liquid inlet 2025 of the liquid drainage channel is an opening located on the side wall of the extended structure. This opening is the liquid inlet of the liquid drainage channel and is also located below the sealing element. For another example, as Fig.23 shown, when the sealing element 2028 enters the connection channel, the inlet 2025 of the liquid drainage channel located below the sealing element discharges the excess liquid to the outside, thereby reducing the resistance for the sealing element to enter. In some preferred ways, different from the structure Fig.31 shown, the sealing element 3028 without the sealing ring 208 is part of the connection structure 3024 as the sealing element. At the same time, there is an opening 3025 at the top of the extended structure of the connection structure. This opening 3025 communicates with the hollow receiving cavity 2039 in the sealing element. When the sealing element enters the connection channel, the excess liquid sample enters the receiving cavity through the liquid drainage channel inlet 3025. For example Figure 33-Figure 35 shown, although the sealing element 4029 is detachably combined with the connecting rod 4024, a liquid inlet 4038 is provided at the top of the sealing element, which can function to discharge the excess liquid. It can be understood that in order to better seal the connection channel, the shape or size of the sealing element is preferably matched with the connection channel. For example, if the connection channel is a circular hollow structure, the sealing element is also a circular structure, which is convenient for the sealing fit between the two.

[0193] Continuing to refer to Figure 33-Figure 35 , a connecting rod 5023 is provided on the first cover 502. There is a sealing element 5028 on this connecting rod. This sealing element can be used to seal the connection channel. When using the above-described sealing element 4028 to seal the connection channel, a liquid inlet 4038 of the liquid drainage channel is provided at its top 4029. And the sealing element 5028 includes a receiving cavity 5030 to collect the liquid discharged when the sealing element enters the connection channel. Of course, a liquid inlet 5025 can also be provided below the sealing element 5028. When the sealing element 5028 enters the connection channel to seal the connection channel, the excess liquid enters the receiving cavity through the liquid inlet 5025, that is, the hollow structure serves as the receiving cavity 5030. At this time, the component 4029 does not play a sealing role but a liquid drainage role, and the sealing role is at the extended end 4028 of the connecting rod 4024.

[0194] Of course, if instead of using a part of the structure 5028 of the connecting rod 5022 as the sealing element, a sealing element 5029 is provided on the structure shown as 5035, as Figure 33-Figure 35As shown, the sealing element 5029 can be detachably connected to the connecting rod, for example, by plugging, threading, or clamping. For example, the element 5035 includes an end 5030 with an external thread that mates with the internal thread 5027 of the connecting rod. The sealing element 5029 mates with the inner wall of the connecting channel to seal the connecting channel. The liquid inlet of the liquid drainage channel is provided at the top 5038 of the element 5035. When the sealing element 5029 enters the connecting channel, the excess liquid head enters the receiving cavity 4029 inside the sealing element through the liquid inlet 4038. At this time, the liquid inlet 5025 can be absent or omitted.

[0195] In some preferred ways, to facilitate the drainage of liquid and also effectively allow the inlet liquid to enter the liquid inlet, the vertical plane position of the liquid inlet of the liquid drainage channel should be lower than the vertical position of the outermost surface of the sealing element. In other words, the horizontal projection area of the liquid inlet of the liquid drainage channel does not completely coincide with the horizontal projection area of the sealing element. Preferably, the horizontal projection area of the liquid inlet of the liquid drainage channel is located within the horizontal projection area of the sealing element. Understood from another perspective, it means that the sealing element needs to contact the inner wall of the connecting channel, and the position of the liquid inlet of the liquid drainage channel is preferably not in contact with the inner wall of the connecting channel because contact will seal the liquid inlet; this facilitates the liquid to enter the liquid inlet of the liquid drainage channel and be drained. For example Figure 2 and Figure 3 It can be seen that the diameter of the position of the sealing element with the sealing ring 108 is greater than the diameter of the position where the liquid inlet 1025 is located, so as to prevent the position where the liquid inlet 1025 is located from contacting the inner wall of the connecting channel and affecting the smooth entry of the liquid into the liquid drainage channel and thus reaching the receiving cavity. In Figure 2 it, the dotted area 1055 is the projected area A - A' of the sealing element, and the projected area point or area of the liquid inlet 1025 is at B, and this projected area is located between A - A'. Therefore, based on this principle, in some solutions, the sealing element can have an inverted cone structure (the function of this structure, that is, having a liquid drainage function, will also be described later), and the liquid inlet 1025 of the liquid drainage channel is located on the surface of the cone. In this way, the liquid inlet of the liquid drainage channel does not contact the inner surface of the connecting channel, facilitating the liquid to be drained to enter the liquid inlet of the liquid drainage channel and be drained. For Fig.18 it can also be understood that due to the presence of the sealing ring 208 at the position of the sealing element 2028, the projection of the liquid inlet 2025 located at the sealing element 2028 is within the projection of the sealing ring. Similarly Fig. 27 it can also be easily understood that with an inverted cone shape and the liquid inlet of the liquid drainage channel provided on the surface of the cone, it is easy for the liquid to enter the liquid drainage channel, thereby draining the excess liquid sample. For example Figure 31-Figure 32In it, the liquid inlet of the liquid drainage channel is set at the top position, and the situation of sealing the liquid inlet of the liquid drainage channel by the side wall of the connection channel is not considered. However, it still satisfies the principle that the projection of the liquid inlet position is located within the horizontal projection area of the sealing element. Let's look at Figure 33-Figure 34 , whether the extended end 5028 of the connecting rod 5023 is used as the sealing element or the part shown by 5029 is used as the sealing element, the projection of the liquid inlet 5025 or 5027 of the liquid drainage channel is still located within the horizontal projection of the sealing element. This is because the liquid inlet 5025 or 5027 is set in the recess, and this liquid inlet will not be sealed or blocked by the side wall of the connection channel. Generally, the inner wall of the connection channel is flat and smooth, so it is easy to be sealed. Such a structure is convenient for liquid drainage.

[0196] In summary, when the sealing element seals the connection channel, the preferred way is to let the sealing element enter the connection channel. To reduce the pressure for the sealing element to enter, a liquid drainage channel needs to be set up to drain the liquid discharged by the sealing element entering the connection channel to another place. Just like the specific way described above, the liquid inlet of the liquid drainage channel is set under the sealing element, and one end inlet of the liquid drainage channel enters the connection channel earlier than the sealing element, so that the excess liquid can enter the liquid drainage channel. Also as described above, when the receiving cavity is inside the sealing element or in other positions, the other outlet (liquid outlet) of the liquid drainage channel communicates with the receiving cavity, so as to receive the excess liquid in the connection channel.

[0197] In some other alternative solutions, the first cavity can also be used as the receiving cavity, so that the liquid sample discharged by the sealing element in the connection channel can be drained into the first cavity through the liquid drainage channel. In the above embodiments, the inlet of the liquid drainage channel is located on the sealing element or on the connection structure integrally connected with the cover body or under the sealing element. Of course, optionally, the liquid drainage channel is not located on the sealing element and can be located on the connection channel. For example, the liquid drainage channel is located on the side wall of the connection channel, the inlet (liquid inlet) of the liquid drainage channel is located on the side wall of the connection channel, and the liquid outlet communicates with the first cavity. When the sealing element enters the connection channel, the excess liquid discharged due to the entry of the sealing element enters the first cavity through the liquid inlet of the liquid drainage channel until the sealing element seals the entry of the liquid drainage channel. Those of ordinary skill in the art can imagine that no matter how the liquid drainage channel is set, such as the setting of the liquid inlet and liquid outlet positions, as long as it can drain the liquid sample discharged by the sealing element entering the connection channel, thereby reducing the resistance of the liquid of the sealing element to the sealing element, it is okay. For example, the liquid inlet of the liquid drainage channel can be located above the sealing element or in other positions.

[0198] In some other ways, the size of the liquid inlet can be designed arbitrarily. For example, liquid can enter, but it cannot flow out freely from the liquid inlet. Because the liquid enters the liquid-repellent channel through the liquid inlet usually due to the pressure of the liquid, when the liquid enters the liquid-repellent channel, the liquid will not flow out from the liquid inlet due to the surface tension of the liquid inlet. The advantage of this is that since the liquid inlet is generally located under the sealing element, when the second cavity is separated from the connection channel, the liquid inlet is exposed. If the liquid in the receiving cavity can flow out through the liquid inlet, it will also cause the risk of contaminating the environment with the liquid sample. Therefore, it is desirable that the liquid inlet can only allow liquid to enter but not flow out. Generally, the size of the liquid inlet is set, such as 0.1 - 1 - 2 millimeters, and the liquid in the receiving cavity will not flow out from the liquid inlet due to surface tension.

[0199] In some ways, after the sealing element seals the connection channel, it can be separated from the first cover when the sealing element is provided on the cover. In one way, the sealing element is integrated with or combined with the cover, and the sealing element seals the connection channel as the first cover closes the opening of the first cavity. When the sealing is completed, if it is necessary to open the first cover, and thus reverse-rotate the first cover to expose the opening of the first cavity. At this time, let the sealing element still stay in the connection channel to seal the connection channel, and removing the first cover allows taking away some liquid samples from the first cavity for further testing or analysis. For example, as Figure 33-Figure 35 shown, the sealing element 5029 and the cover are detachably combined through the connecting rod 5023. At this time, the sealing element 5029 is located on the element 5035. And the element 5035 is detachably combined with the connecting rod 5023 of the cover. This detachable way is not the Figure 33-Figure 35 thread structure shown, but the plug-in way, that is, one end 5030 of the element 5035 is inserted into one end of the connecting rod. When the first cover 502 drives the sealing element 5029 to seal the connection channel, at this time, the second cavity can be separated from the first cavity, so as to seal the opening of the second cavity. For example, use the second cover to seal the opening of the second cavity, and use the sample in the second cavity for the second test. At this time, the first cover 502 has already closed the first cavity, for example Fig. 9The opening 1031 of the first chamber 103 shown; if it is necessary to take out a liquid sample from the first chamber at this time, the first cover is reversed at this time. When reversing, at this time, the sealing element has a relatively tight fit with the connection channel, and the element 5035 is only inserted into the connecting rod. The first cover can be separated from the first chamber again, and the element 5035 is left in the connection channel. The advantage of this design is that if the first chamber is only used for collecting samples, after the sample is collected, the connection channel is sealed and the liquid sample is separated. At this time, the first cover can be opened, and part of the sample can be taken out from the first chamber for testing. If the test result needs to be further confirmed, the second chamber can be removed from the first chamber for secondary testing. In fact, samples can be taken out from the first chamber multiple times for multiple tests or assays with different indicators.

[0200] The liquid to be excluded above generally occurs when both the connection channel and the second chamber are filled with liquid samples. It can be understood that when the liquid sample in the second chamber does not fill the second chamber, the connection channel generally does not contain liquid samples either. When the sealing element enters the connection channel to seal the connection channel, the liquid drainage channel can drain the compressed part of the gas outside the second chamber at this time, and can also reduce the resistance of the sealing element entering the connection channel. The resistance at this time is the reaction force generated by the gas compression to hinder the entry of the sealing element.

[0201] Therefore, in some preferred embodiments, in these two cases, when the connection channel has liquid, the function of the liquid-repellent channel is to drain the liquid; when the second chamber is not filled with liquid, in order to better seal the connection channel by the sealing element, the function of the liquid-repellent channel at this time is to exhaust air. Therefore, the liquid-repellent channel functions as both or either of these two functions simultaneously. Therefore, the liquid-repellent channel can also be called a fluid-draining channel, where the fluid refers to liquid or gas, or a mixture of both. Correspondingly, the liquid inlet of the liquid-repellent channel can also be called the air inlet, the liquid outlet can also be called the air outlet, or collectively the fluid inlet and the fluid outlet. It can be understood that when it is necessary to exhaust the compressed gas, there is no need to specifically provide an exhaust channel, and the liquid-repellent channel can be used to achieve exhaust, or such a channel does not need to be specifically designed, because when there is liquid in the sealing element, as long as the liquid seal is achieved. If there is gas, in fact, only the liquid seal needs to be achieved. Therefore, when it is necessary to exhaust gas, the gas-exhausting function can be achieved in the small gaps between the sealing element and the connection channel element. These small gaps can be the errors between mechanical structures or deliberately designed structures that allow gas to pass through but not liquid, thus achieving the effect of exhausting gas. Of course, the exhaust channel or the exhaust structure here is not necessary, because what the sealing element needs to seal the connection channel is the liquid seal effect, not the gas seal effect. Relatively speaking, achieving a liquid seal does not necessarily mean achieving a gas seal, but when a gas seal is achieved, the liquid seal effect is also achieved.

[0202] The "liquid-repellent channel" is also a preferred embodiment of the present invention because the sealing element can better seal the connection channel by allowing part of the sealing element to enter the connection channel to achieve a better sealing effect. In other ways, if the sealing element only seals the first opening of the connection channel and does not need to seal the opening but needs to enter a certain distance into one end of the connection channel, it is also feasible. At this time, the liquid-repellent channel can be omitted. If there is other space in the second chamber that is not filled with liquid, the liquid-repellent channel can also be omitted because the role of the sealing opening or the connection channel becomes less important as there will be no liquid leakage.

[0203] In addition, in another case, it is also possible not to provide a structure similar to the liquid-repellent channel. For example, as shown in the figure (Design 2, when using a lid to seal the opening of the connection channel, the liquid-repellent channel is not required)

[0204] Drainage element

[0205] In some preferred embodiments, the device of the present invention may further include a liquid discharging element for discharging a part of the liquid sample in the second chamber. The so-called "liquid discharging element" refers to an object that, when entering the liquid sample, occupies a certain space of the liquid due to its volume, thereby discharging a certain volume of liquid. The volume of the object entering the liquid is the volume of the discharged liquid, and the object entering the liquid can be called a liquid discharging element. This can be understood as similar to a ship in water, where due to the weight of the ship, a certain volume of water needs to be discharged, and the ship occupies the space originally occupied by the water. Of course, as mentioned above, when the space contains gas instead of liquid, after the liquid discharging element enters the space containing gas, what is discharged is gas rather than liquid.

[0206] In other embodiments, for example, when the second chamber is filled with the liquid sample, even if the sealing element seals the connection channel, however, the liquid in the second chamber completely and substantially fills the liquid sample. When it is necessary to detach the second chamber from the first chamber, due to mechanical operations, the liquid in the full second chamber will overflow due to mechanical operations, causing unfriendly operation and also causing pollution to the outside or the operator. Additionally, even if the second chamber filled with the liquid sample is carefully removed or detached from the first chamber, it is not easy to seal the opening of the second chamber with the second cover. Thus, there may be some leakage risks during the transportation of the second chamber filled with the liquid. Therefore, in some more preferred embodiments, it is necessary to discharge a part of the liquid sample in the second chamber outside the second chamber either at the same time as, after, or before the sealing element seals the connection channel. Thus, the liquid in the second chamber is not filled completely, so that the liquid sample in the second chamber separated from the first chamber will not overflow, increasing the safety and friendliness of the operation. At the same time, it also reduces the leakage risk during the subsequent secondary detection transportation process and increases the friendliness and safety of the subsequent secondary detection operation.

[0207] When the second chamber is detached from the device, for example Fig.13 as shown, a certain space is reserved in the second chamber, and the liquid does not fill the second chamber completely. In this way, when disassembling, the liquid sample will not overflow from the second chamber, reducing the risk of polluting the outside.

[0208] In some preferred embodiments, the device further includes a liquid discharging element for discharging the liquid sample in the second chamber outside the second chamber. It can be understood that the liquid discharging element can be any structure or method for reducing the liquid sample in the second chamber. In some preferred embodiments, the liquid discharging element is formed as an extension of the sealing element, or the liquid discharging element is located on the sealing element. For example, in Figure 2-Figure 3 in Fig.18 , Fig.23 , Fig. 27 , Fig.31, Fig.33 The structure shown schematically. For example Figure 2-Figure 3 In, the sealing element 1028 and the liquid discharge element 1027 are of an integral structure. The shape of the liquid discharge structure 1017 and the sealing element 1028 is generally equivalent, except that the longitudinal dimension is slightly larger than that of the sealing element, and the transverse dimension is smaller than that of the sealing element. At this time, it is also possible that the horizontal projection of the liquid discharge element is located within the horizontal projection of the sealing element, or part of the horizontal projection of the liquid discharge element is located within the horizontal projection of the sealing element. At this time, when the sealing element enters the connection channel, first, the liquid discharge element 1027 enters the connection channel. Since the diameter of the liquid discharge element 1027 is smaller than the diameter of the connection channel 109, all the excess liquid sample is discharged outside the second chamber 104 or into the first chamber 103 outside the connection channel 109 through the space or gap 809 between the surface of the liquid discharge element and the surface of the connection channel 109. As the liquid discharge element 1027 further enters the second chamber (such as Fig. 22 , Fig.12 ), at this time, the sealing element begins to seal the opening 1091 of the connection channel 109, and thus, according to the above description, the liquid sealing connection channel is sealed. Since the liquid discharge element 1027 enters the second chamber, part of the liquid sample in the second chamber is discharged. When the sealing element 1028 starts to seal the opening 1091 of the connection channel, at this time, the liquid sample located below the opening 1091 of the connection channel cannot be discharged through the space between the surface of the liquid discharge element 1027 and the surface of the connection channel 109. At this time, if the sealing element still needs to move downward, at this time, the liquid sample continuously discharged by the liquid discharge element and the liquid sample discharged by the sealing element itself enter the liquid drainage channel through the inlet of the liquid drainage channel, and thus enter the receiving cavity. Therefore, in some preferred ways, the inlet of the liquid drainage channel is located on the liquid discharge element. More preferably, the receiving cavity is located within the liquid discharge element. It can be easily understood that the sealing element and the liquid discharge element can be integrally injection-molded. During injection molding, it is injection-molded into a hollow structure, so as to form a receiving cavity to receive the discharged liquid.

[0209] As mentioned above, in order to smoothly let the liquid enter the inlet of the liquid drainage channel and be discharged outside, the transverse diameter of the liquid discharge element is smaller than the inner diameter of the connection channel. For example, the liquid discharge element can be in the shape of an inverted cone, and such as Fig.18 the liquid discharge element, that is, the conical structure where the inlet 3025 of the liquid drainage channel is located. For example Fig. 27 the liquid discharge element 3027 in is of an inverted cone structure. Fig.31 And Fig.32 the conical structure 4027 under the sealing element 4029 shown in, such as Figure 33-Figure 35The conical structure formed by the liquid discharge structure 435 shown. In fact, the liquid discharge structure does not require a separate structure. If the sealing element is long enough, the sealing element can extend into the second chamber. At this time, the sealing element can play a dual role, that is, it realizes the change of the liquid flow state between the second chamber and the first chamber, and at the same time discharges part of the liquid in the second chamber. Therefore, the liquid discharge element is only a functional limitation, rather than requiring a separate additional structure to achieve. In fact, these conical structures can also be used as liquid discharge elements, which will be described in detail later.

[0210] In other ways, for example Fig.15 , Fig.18 , Figure 22-23 , Fig. 27 As shown, the liquid discharge elements 2027, 3027 are connected to the sealing elements 2028, 3028 and are formed by the extension of the sealing elements. A sealing ring 208 is provided outside the sealing element 2024. In this way, the sealing ring 208 is provided on the surface of the sealing element and is slightly higher than the outer surface of the sealing element 2014. In this way, even if the diameter of the liquid discharge element 2017 is the same as the diameter of the sealing element 2024, when the liquid discharge element 2027 enters the connection channel 209 (for example, as Fig. 22 ), at this time, the sealing element and the liquid discharge element enter the connection channel together. Since the liquid discharge element is at the end and the sealing element is above the liquid discharge element, the liquid discharge element first enters the connection channel. If there is liquid in the connection channel, the liquid discharged by the liquid discharge element entering the connection channel enters the first chamber 103 through the gap 809 between the surface of the liquid discharge element and the inner surface of the connection channel. As the sealing element and the liquid discharge element move further, the liquid discharge element 2027 enters the first chamber. At this time, the sealing ring may not yet seal the opening 2091 of the connection channel 209. As the liquid discharge element 2027 further enters the second chamber 204, the liquid can still be discharged into the first chamber 203 through the gap 809. When the sealing ring 2023 on the sealing element 2024 seals the opening 2091 of the connection channel 209, the liquid cannot be discharged into the first chamber through the gap 900. At this time, the sealing element and the sealing ring need to continue to move in the connection channel to achieve a stable sealing effect. Continuing to move requires continuing to discharge the liquid sample. At this time, the excess liquid sample discharged is discharged out of the connection channel and the second chamber through the liquid inlet 2025 of the liquid drainage channel. For example, it enters the liquid drainage channel through the inlet 2025 of the liquid drainage channel, and then enters the receiving chamber 2029 or the first chamber through the outlet of the liquid drainage channel. At this time, separate the second chamber 204 from the device, for example Fig.24 , Fig.28As shown, it is separated from the connection channel. Since the liquid drainage element 2027 is located in the second chamber, part of the liquid sample in the second chamber is drained. When the second chamber is detached from the device, for example Fig.28 As shown, a certain space is reserved in the second chamber, so the liquid does not fill the second chamber completely. In this way, when disassembling, the liquid sample will not overflow from the second chamber, reducing the risk of contaminating the outside.

[0211] It can be understood that the liquid drainage element and the sealing element have the same size. Before the sealing element seals the connection channel, the liquid in the connection channel can be drained not through the gap, but through the liquid inlet of the liquid drainage channel to the outside of the two connection channels or outside the second chamber.

[0212] In some other ways, there is no obvious division between the sealing element and the liquid drainage element. For example, as Figure 31-Figure 32 shown, there is no sealing ring on the sealing element 5028. The liquid drainage element 5027 and the sealing element 5028 are on the extension section of the connection structure 5023. One end of the connection structure 5023 is connected to the first cover 502, and the other end is connected to the sealing element 5028 or is the end of the connection structure. The sealing element 5028 is also connected to the liquid drainage element 5027. The liquid inlet 5025 of the liquid drainage channel is located at the end of the liquid drainage element. The receiving cavity is located inside the liquid drainage element or inside the sealing element, or inside the connection structure. When the connection structure, the sealing element and the liquid drainage element are hollow structures, the liquid outlet of the liquid drainage channel communicates with the receiving cavity. Referring to the above description, when such a liquid drainage element 5027 enters the connection channel, the drained liquid enters the liquid drainage channel through the liquid inlet 5038 located at the end of the liquid drainage element, and then enters the receiving cavity through the liquid outlet of the liquid drainage channel. The liquid inlet can be set to such a size that the liquid can pass through smoothly, but the liquid entering the receiving cavity will not leak out from the liquid inlet due to the surface tension of the liquid at the liquid inlet. This is because once the liquid drainage element passes through the openings 2091, 1091 of the connection channel and enters the connection channels 109, 209, the surface of the liquid drainage element 5027 forms a seal with the inner surface of the connection channel 209. At this time, the liquid drainage element and the sealing structure are the same structure, and the liquid drainage element simultaneously plays the dual roles of sealing the connection channel and draining the liquid. As the liquid drainage element moves in the connection channel, it will exert a pressure on the liquid in the connection channel, and this pressure acts on the liquid drainage element in the opposite direction, thereby increasing the difficulty of the liquid drainage element 4027 entering the connection channel. In order to reduce the reaction force of the liquid, the excess liquid enters the liquid inlet 4025 of the liquid drainage channel, and then enters the receiving cavity 4029 in the liquid drainage structure 4027.

[0213] When the second chamber is separated from the device, since the liquid discharging element 1027 is located in the second chamber, part of the liquid sample in the second chamber is discharged. When the second chamber is detached from the device, for example Fig.13 as shown, a certain space is reserved in the second chamber, and the liquid does not fill the second chamber completely. In this way, when disassembling, the liquid sample will not overflow from the second chamber, reducing the risk of contaminating the outside. In addition, due to the surface tension at the liquid inlet 3025, the liquid sample located in the receiving chamber will not leak out through the liquid inlet 3025.

[0214] In some ways, for example Figure 33-Figure 35 as shown, the component 5035 can be used as the liquid discharging element and the sealing element 5028 is located on the connecting rod 5024. At this time, the liquid discharging element and the sealing element are detachably connected. The overall lateral dimension of the liquid discharging element 5035 is smaller than the dimension of the sealing element 5028. For example, the diameter of the liquid discharging element is smaller than the dimension of the sealing element 5028 (as Fig.33 shown). The connection between the liquid discharging element and the sealing element is in a threaded manner. For example, as Fig.35 A and Fig.35 B shown, the sealing element 5028 has a hollow structure with internal threads provided on the inner surface, and the liquid discharging element 5035 has an upward extending section 5030 at one end, with external threads provided on the extending section. In this way, through the cooperation of the internal and external threads, the liquid discharging element can be connected to the sealing element 5028. When the sealing element and the liquid discharging element enter the connection channel 209, since the dimension of the liquid discharging element is smaller than the dimension of the connection channel, the liquid discharging element can easily enter the connection channel, and the excess liquid enters the first chamber through the gap between the liquid discharging element and the connection channel. After the sealing element seals the opening 2091 of the connection channel 209, the liquid cannot enter the first chamber through the gap. As the sealing element enters the connection channel, the excess liquid enters the receiving chamber or the first chamber through the liquid inlet 4025 of the liquid drainage channel.

[0215] In some preferred ways, referring again to Fig.33 and Fig.35 , the dimension of the liquid discharging element 5035 is equivalent to the diameter of the sealing element 5028, or the dimension of the liquid discharging element is smaller than the diameter of the sealing element. The liquid inlet 5025 of the liquid drainage channel is provided on the extending section 5030. Through Fig.34It can be seen that the diameter of the place with the liquid inlet 5025 is smaller than the diameter of the sealing element 5028 and also smaller than the diameter of the liquid discharge element 5029, forming a concave area at the liquid inlet 5025. In this way, when the liquid discharge element 5035 enters the connection channel 209, the liquid discharged by the discharge structure 5029 passes through the liquid inlet 4025 of the liquid drainage channel at the concave part and is discharged. By the same token, as the liquid discharge element further enters the connection channel and then enters the space of the second chamber, the sealing element seals the opening 2091 of the connection channel. When it later enters the connection channel, the liquid discharged by one or both of them can pass through the liquid inlet 5025 of the liquid drainage channel and be discharged, for example, into the receiving chamber or the first chamber. It can be understood that the liquid discharge element is also a preferred way here and is not a necessary way to implement the present invention.

[0216] Movement of sealing or drain elements

[0217] As mentioned above, the sealing element seals the connection channel, and the liquid discharge element also enters the connection channel or the second chamber. These are all processes of movement. To initiate the movement of these sealing elements and liquid discharge elements, a certain external force or another mechanical structure is needed to make the sealing element and / or the liquid discharge element move. Therefore, the sealing element and the liquid discharge element can move in a linked manner. For example, the movement of the sealing element drives the movement of the liquid discharge element; for another example, the movement of the liquid discharge element drives the movement of the sealing element.

[0218] The so-called "linked movement" here means that the movement of one object directly or indirectly drives the movement of another object. Usually, the movement modes of the two objects are the same. For example, if one object moves in a rotational motion, the object it drives also moves in a rotational motion; for example, if one object moves in an insertion motion, the other object it drives also moves in an insertion motion. Another example is that when one object moves from the initial position to the end position, during this movement process, it drives another object to also move from the initial position to the end position. Rotational motion can achieve the movement from the initial position to the end position. Of course, rotation and insertion can be used in combination or separately. Here, the meanings of "movement" and "displacement" can be understood interchangeably.

[0219] The first cover moves in a linkage manner with the sealing element or the liquid discharging element, that is, the movement of the first cover drives the movement of the sealing element, thereby driving the movement of the liquid discharging element. Or, the first cover and the liquid discharging element move in a linkage manner, that is, the movement of the first cover drives the movement of the liquid discharging element, thereby driving the movement of the sealing element. In some preferred ways, the sealing element is located on the first cover. When the cover closes the opening of the first cavity, the cover drives the sealing element to seal the connection channel, forming a sealed state. As described above, the sealing of the connection channel by the sealing element is generally divided into three states. The first state is that the sealing element does not contact the opening of the connection channel. For example, Fig. 22 As shown, the first cover 202 is provided with a sealing element 2028. When the cover closes the opening 2031 of the first cavity 203, it drives the sealing element 2028 into the first cavity. At this time, the sealing element does not contact the first opening 2091 of the connection channel( Fig. 22 ). At this time, the connection channel connects the first cavity and the second cavity. At the same time, the first cavity and the second cavity are in liquid communication through the channel. As the cover closes the opening 2031 of the first cavity, the cover moves downward along the longitudinal axis of the first cavity, driving the sealing element to gradually approach the opening 2091 of the connection channel. At this time, as the first cover is further closed, the sealing element 2028 contacts the first opening 2091 of the connection channel 209, thereby sealing the opening( Fig.23 ). At this time, it can be considered that the connection channel 209 is sealed. However, in order to ensure a more stable sealing of the connection channel, it is desirable for the sealing element to enter the connection channel 209 by a certain distance, so as to more stably seal the connection channel. At this time, the cover still needs to be closed to push the sealing element 2028 into the connection channel. A similar process is shown in, for example Figure 12-Figure 27 . Regardless of the type or form of the sealing element, it is a preferred way for these sealing elements and the cover to move simultaneously. Of course, the movement of the cover and the movement of the sealing element can also be separate movements. For example, the first cover is used to close the opening of the first cavity to complete the closing process. The sealing element, instead, completes the sealing of the connection channel through a separate movement and does not cooperate with the first cover to complete it.

[0220] As for the liquid discharge element, its function is to discharge some of the liquid in the second chamber. As previously mentioned, when the second chamber is filled with liquid, the liquid discharge element is required to discharge the liquid. However, if the second chamber is not filled with liquid, the liquid discharge element may not be needed at this time. Therefore, the liquid discharge element is a preferred way of the present invention, rather than a necessary way. When the liquid discharge element is needed, the liquid discharge element and the cover body can be connected into an integral structure. In this way, the movement of the cover body drives the movement of the liquid discharge element, so as to insert into the second chamber to discharge the liquid. Of course, as previously mentioned, the sealing element and the liquid discharge element are two different elements, and the liquid discharge element enters the second chamber prior to the sealing element. In a preferred way, the liquid discharge element enters the connection channel prior to the sealing element, and then enters the second chamber. For such a design, the liquid discharge element is located at the end of the sealing element, further away from the first cover body, so as to achieve such a functional design.

[0221] Therefore, in some preferred ways of the present invention, the present invention provides a cover body, and a sealing element for sealing the connection channel is provided on the cover body. In some preferred ways, a sealing ring is provided on the sealing element. In some preferred ways, the materials of the sealing element and the connection channel are the same or different. In some preferred ways, the sealing element is made of a flexible material, and the connection channel is made of a rigid material. In some preferred ways, the sealing element is connected to the first cover body into an integral structure through a connecting rod. In some preferred ways, the sealing element further includes an opening of the liquid drainage channel. In some preferred ways, the opening of the liquid drainage channel is located below the sealing element, or the opening of the liquid drainage channel enters the connection channel prior to the sealing element. In some preferred ways, the cover body further includes a receiving cavity, which is in liquid communication with the liquid drainage channel. The receiving cavity is connected to the liquid outlet of the liquid drainage channel. In some preferred ways, the receiving cavity is located in the sealing element.

[0222] In some other preferred ways, a liquid discharge element is further provided on the first cover body, and the liquid discharge element is further away from the first cover body than the sealing element. Or, the liquid discharge element is provided below the sealing element, or the sealing element and the liquid discharge element are arranged such that the liquid discharge element enters the second chamber prior to the sealing element, or the liquid discharge element enters the connection channel prior to the sealing element. Or, when a connecting rod is provided on the cover body to connect the first cover body and the sealing element, and at the same time the sealing element is connected to the liquid discharge element. Or, the connecting rod, the sealing element and the liquid discharge element are of an integral structure.

[0223] In another way, if the first chamber and the second chamber are not initially in a liquid flow state, but after a liquid sample is collected in the first chamber, it is necessary to put the first chamber and the second chamber in a liquid flow state. At this time, the cover body can be provided with a first element for putting the first chamber and the second chamber in a flow state and a second element for preventing the first chamber and the second chamber from being in a fluid state. For example, the first chamber and the second chamber are not initially in a liquid flow state when a sealing element has initially sealed the first opening 1091 of the connection channel. If the cover body is linked with the first element and the second element, first, the first element is brought into contact with the sealing element. For example, when the sealing element is a structure that is easily punctured, the first element is a sharp puncturing structure. After puncturing, the liquid in the first chamber enters the second chamber. Subsequently, the second element seals the first opening, thereby realizing the change of the liquid flow state. Thus, the second chamber can be separated from the first chamber. Those skilled in the art can understand that the second element can be a replacement mode of any of the sealing elements described above, and can also include a liquid discharging element, or the setting of a liquid draining channel, etc. For example, in the specific embodiments Figure 37-Figure 40 as shown above.

[0224] The first cover and the second cover

[0225] The first cover body is here the cover body for covering the first chamber, and the second cover body is used to cover the opening of the second chamber. Specific examples of the cover body can be as Figure 1-Figure 28 the shape of the cover body shown above. Of course, the actual function of the cover body is to cover the opening of the first chamber. The first cover body does not necessarily need to seal the opening of the first chamber. However, the main function of the second cover body is to seal the opening of the second chamber to prevent leakage of the liquid sample. Therefore, in some ways, the second cover body is located on the first cover body, and the second cover body is detachably combined with the first cover body. For example, the second cover body is combined together by means of threads or other plugging methods. When it is necessary to use the second cover body for sealing, generally when liquid-sealing the opening of the second chamber, the second cover body is taken off from the first cover body to seal the second chamber.

[0226] Methods for testing or collecting fluid samples

[0227] The present invention also provides a method for collecting a liquid sample, the method comprising providing the aforementioned device for collecting a liquid sample, the device including a first chamber and a second chamber, wherein the second chamber and the first chamber are connected in a detachable manner, using the first chamber to collect the liquid sample, and allowing the liquid sample to flow into the second chamber. In some preferred embodiments, when the second chamber has collected the liquid sample, the second chamber is separated from the first chamber, so that the opening of the second chamber is covered by the second cover. In some preferred embodiments, before separating the first chamber from the second chamber, the first chamber is not in a fluid communication state with the second chamber. In some preferred embodiments, a sealing element is used to isolate the first chamber and the second chamber, so that the first chamber and the second chamber are not in a communicating state.

[0228] In some preferred embodiments, the first chamber and the second chamber are connected together through a connecting channel, wherein a first opening of the connecting channel is in fluid communication with the first chamber, and a second opening of the connecting channel is in fluid communication with the second chamber. By separating the second chamber from the connecting channel, the second chamber is separated from the first chamber; or, the second chamber is detachably connected to the connecting channel, while the connecting channel is not detachably connected to the first chamber; or, the second chamber is detachably connected to the connecting channel, and the connecting channel is also detachably connected to the first chamber.

[0229] In some embodiments, when the second chamber is detachably connected to the first chamber through the connecting channel, a sealing element is used to seal the connecting channel. Therefore, in some preferred embodiments, the device further includes a sealing element, and before the second chamber is separated from the first chamber, the sealing element seals the connecting channel. In some preferred embodiments, the device further includes a cover, the cover and the sealing element are integrally structured, and when the cover covers the opening of the first chamber, the cover drives the sealing element to seal the first opening of the connecting channel at the same time. In some preferred embodiments, the cover drives the sealing element into the connecting channel. In some preferred embodiments, after the sealing element seals the connecting channel, the second chamber is separated from the first chamber. In some preferred embodiments, a liquid discharging element for discharging a part of the liquid in the second chamber is further provided on the cover, and the cover drives the liquid discharging element into the second chamber. In some preferred embodiments, a sealing element and a liquid discharging element are provided on the cover, and the liquid discharging element enters the second chamber before the sealing element. In some preferred embodiments, the device further includes a liquid repellent channel, and the liquid sample discharged by the liquid discharging element is discharged out of the second chamber through the liquid repellent channel. In some preferred embodiments, when the sealing element enters the connecting channel, the liquid discharged by the sealing element is discharged out of the connecting channel through the liquid repellent channel. In some preferred embodiments, the liquid discharged by the sealing element or the liquid discharging element is discharged into the first chamber through the liquid repellent channel. In some preferred embodiments, a receiving cavity is provided on the cover, and the receiving cavity is in fluid communication with the liquid repellent channel, wherein the liquid discharged by the sealing element and / or the liquid discharging element is discharged into the receiving cavity through the liquid repellent channel.

[0230] In some ways, the liquid-repellent channel has a liquid inlet and a liquid outlet. The liquid discharged by the sealing element and / or the liquid discharging element enters the liquid inlet, and then enters the receiving cavity through the liquid outlet of the liquid-repellent channel.

[0231] In other ways, a sealing element is provided on the cover body. When the cover body closes the opening of the first cavity, the sealing element is driven to seal the connection channel. In some ways, when the first cover body leaves the opening of the first cavity again, the sealing element remains in the connection channel. In the latter case, the sealing element is separated from the cover body.

[0232] On the other hand, the present invention provides a method for detecting whether an analyte exists in a liquid sample. The method includes the liquid collection device in any of the above ways. After the first cavity collects the liquid sample, a test element is used to detect the liquid sample from the first cavity. After obtaining the detection result, the second cavity is separated from the first cavity in any of the above ways. In some specific ways, the device further includes a detection cavity for accommodating the test element. When the detection cavity is in fluid communication with the first cavity, after the first cavity collects the liquid sample, the liquid flows into the detection cavity. When the detection cavity includes a test element, after the test element completes the detection, the second cavity is separated from the first cavity. In some preferred ways, the liquid sample first enters the detection cavity from the first cavity and then enters the second cavity. Such a structure is as described in the previous structural design, so as to prevent the liquid entering the detection cavity from also entering the second cavity and thus contaminating the liquid sample in the second cavity.

[0233] Detection chamber

[0234] The detection cavity in the present invention is used to analyze and test whether an analyte exists in the liquid sample from the first cavity. The detection cavity may not be provided with a detection device. Generally, the detection cavity includes a test element, and the test element comes into contact with the liquid sample to conduct chemical analysis or testing on the liquid sample. In traditional products, generally when manufacturing a device with a detection cavity, the test element is usually manufactured first or the test element is arranged on a carrier, and then the test element is inserted into the detection cavity, and then the detection cavity is sealed. In this case, the detection cavity generally has an opening for the test element to enter and exit the detection cavity. For example, Figure 1 and Fig. 9As shown, the detection chamber 105 has an opening 1051 at a position close to the opening 1031 of the first chamber 103, and a test element (not shown) placed on the test carrier 106 is located in the card slot 1061 of the test carrier. Then, the carrier 106 is inserted into the detection chamber through the opening of the detection chamber. Usually, after being inserted into the detection chamber, the opening 1051 of the detection chamber needs to be sealed, and the sealing effect and quality requirements are very high. As previously described, the entire detection device or collection device needs to be transported and packaged together. To prevent the liquid in the detection chamber or the first chamber from leaking, any possible leakage points need to be strictly sealed, and the sealing performance of each product needs to be detected, which increases the production cost. However, after adopting the second chamber with secondary confirmation of the present invention, there is no need to deliberately consider these places that previously required good sealing effects. This kind of sealing only needs to be temporary, and there is no need to require permanent sealing. For example, as Fig. 9 shown, for the sealing of the opening 1051 of the detection volume, conventional sealing can be used. For example, heat sealing with a film can be used, as long as it is ensured that the film is airtight and liquid-tight during detection. After the detection is completed, when the second chamber is separated from the first chamber, the first chamber and the detection chamber can be discarded, and there is no need to store and transport the entire detection device.

[0235] Embodiment 1

[0236] Now, specific embodiments will be combined to illustrate how the detection device of the present invention is assembled and operated.

[0237] For example, as Figure 1-Figure 3 , Figure 6-Figure 14 shown in the device, the device includes a first chamber 103 and a second chamber 104, and an opening 1031 for introducing a liquid sample in the first chamber 103. As Figure 1 shown, the first chamber is surrounded by a side wall and a bottom, and there is a raised area at the bottom of the first chamber. For example, as Fig. 9 shown, the raised area is located in the center of the entire bottom. An opening 1091 is provided in the raised area, and there is a connecting channel 109. The first opening 1091 of the connecting channel 109 communicates with the inside of the first chamber 103, and the other opening 1092 communicates with the opening 1042 of the second chamber. A groove is formed around the raised area inside the first chamber, and the groove forms a liquid sample collection area 1035, 1036 (as Figure 7)。A threaded structure 1101 is provided on the outer opposing wall of the connection channel 109 near the second opening 1092, and a threaded structure 1041 is provided on the outer wall of the opening 1042 of the second chamber 104. This thread forms a rotational fit with the thread 1101 on the wall 110, so that the second chamber 104 forms a detachable fit with the first chamber through the connection channel 109. At the same time, it also includes a detection chamber 105, which is in liquid communication with the first chamber through a through hole 1038. A test element is included in the detection chamber. The test element is arranged in the card slot 1061 of the test carrier 106. Generally, the sample application area of the test element is located in the area of the test carrier near the bottom of the second chamber, or near the bottom 1051 of the detection chamber, while the water absorption area of the test element is near the other end of the detection chamber (the end near the opening 1031 of the first chamber).

[0238] A cover 102 is also provided. A connecting rod 1023 is connected to the center of the cover. A sealing element 1028 is provided at the end of the connecting rod, and a sealing ring 108 is provided on the sealing element. At the same time, a liquid discharge element 1027 is provided under the sealing element. The liquid discharge element 1027, the sealing element, and the connecting rod 1023 are integrally formed, just a division of different functional areas. Generally, the lengths of the connecting rod 1023, the sealing element 1038, and the liquid discharge element 1027 are slightly greater than the distance from the opening 1031 of the first chamber 103 to the opening 1042 of the second chamber 104. In this way, the liquid discharge element 1027 can enter the second chamber 104, so as to discharge part of the liquid sample in the second chamber. At the same time, a liquid inlet 1025 of the liquid drainage channel is provided under the sealing element 1028( Figure 2 and Figure 3 ). The liquid inlet 1025 can be located between the liquid discharge element 1027 and the sealing element 1028. At the same time, the sealing element, the liquid discharge element, and the connecting rod are of a hollow structure, and an accommodation chamber 1029 is included inside to collect excess liquid samples. When in use, first let the opening of the first chamber collect the liquid sample. As the liquid sample enters, it accumulates at the bottom of the first chamber, and then enters the detection chamber through the through hole 1038. The liquid sample entering the detection chamber contacts the sample reagent area of the test element, so as to carry out chemical analysis and detection. As the liquid increases, the liquid sample enters the second chamber through the opening 1091 of the connection channel. Then, the liquid sample gradually fills the second chamber 104, then submerges the first opening 1091 of the connection channel, and finally the liquid level is higher than the first opening 1091 of the connection channel 109. At this time, stop collecting the liquid sample. Subsequently, cover the opening 1031 of the first chamber 103 with the first cover 102. As the cover closes the opening 1031, the rotational closing of the cover drives the sealing element 1028, the liquid discharge element 1027, and the liquid inlet 1025 of the liquid drainage channel close to the opening of the connection channel 109 (such as Fig.10 , Fig.11 and Fig.12 ). As the lid rotates, the liquid drainage element 1027 first enters the connection channel 109. At this time, the sealing ring of the sealing element has not yet approached the first opening 1091 of the connection channel. Liquid can enter the first chamber 103 through the gap between the liquid drainage element 1027 and the connection channel 109. As the sealing element enters the connection channel 109, the liquid drained at this time enters the receiving chamber 1029 through the liquid inlet 1025 of the liquid drainage channel, thereby draining the excess liquid sample and also reducing the pressure for the sealing element to enter the connection channel, making it easier to obtain a better seal. After the liquid drainage element enters the second chamber, at this time, the sealing element also seals the connection channel 109. At this time, the test element in the detection chamber has completed the first detection. After deeming it necessary to retain the remaining sample for secondary confirmation and testing, by rotating the second chamber, the second chamber is separated from the first chamber. Since the sealing element seals the connection channel, the liquid sample located in the first chamber will not leak out. Then, the second lid 101 provided on the first lid 102 is used to seal the opening 1042 of the second chamber 104 (as Fig.14 and Fig.13 shown). In this way, the second lid can be stored or packaged and transported to a testing institution for secondary confirmation and testing separately.

[0239] Embodiment 2

[0240] For example, as Figure 15-18 , Figure 23-Figure 28 shown, the device shown includes a first chamber 203 and a second chamber 204, and an opening 2031 for introducing a liquid sample in the first chamber 203. As Fig.16 shown, the first chamber is surrounded by a side wall and a bottom. There is a raised area at the bottom of the first chamber. For example, as Fig.24 shown, the raised area is located at the center of the entire bottom. An opening 2091 is provided in the raised area, and there is a connection channel 209. The first opening 2091 of the connection channel 209 communicates with the inside of the first chamber 203, and the other opening 2092 communicates with the opening 2042 of the second chamber. A groove is formed around the raised area inside the first chamber, and this groove forms a liquid sample collection area 2035, 2034 (as Fig.24)。A threaded structure 2101 is provided on the outer opposing wall of the connection channel 209 near the second opening 2092. A threaded structure 2043 is provided on the outer wall of the opening 2042 of the second chamber 204. This thread forms a rotational fit with the thread 2101 on the wall 210, so that the second chamber 204 forms a detachable fit with the first chamber through the connection channel 209. Meanwhile, a carrier 206 is provided. There are multiple channels on the carrier, one end of each channel is sealed 2062 and the other end is open 2063. One or more test strips are arranged in the channels. The sample application area of the test strip is located at the open end 2063. There is one or more channels for accommodating the test strips in the carrier 206. Each channel is provided with a test element. When there are multiple channels, test elements for different analytes can be arranged in each channel. In this way, multiple analytes can be detected using the same sample. Such a carrier 206 is placed in the first chamber 203. There are two limiting strips 2032 and 2033 on the wall of the chamber 203. The carrier 206 is inserted or snapped into the two limiting slots, so that one end 2065 of the channel with an opening is close to the bottom of the first chamber, and one end 2064 with a sealed channel is close to the opening 2031 of the first chamber( Fig.16 )。When the liquid sample flows into the first chamber through the opening 2031 of the first chamber, the liquid sample comes into contact with the sample application area of the test strip, thus completing the detection.

[0241] A cover 202 is also provided. A connecting rod 2023 is connected to the center of the cover. A sealing element 2028 is provided at the end of the connecting rod. A sealing ring 208 is provided on the sealing element. Meanwhile, a liquid drainage element 2027 is provided under the sealing element. The liquid drainage element 2027, the sealing element 2028 and the connecting rod 2023 are integrally formed, just with different functional area divisions. Generally, the lengths of the connecting rod 2023, the sealing element 2028 and the liquid drainage element 2027 are slightly greater than the distance from the opening 2031 of the first chamber 203 to the opening 2042 of the second chamber 204. In this way, the liquid drainage element 2027 can enter the second chamber 204 to drain part of the liquid sample in the second chamber. Meanwhile, a liquid inlet 2025 for the liquid drainage channel is provided under the sealing element 2028( Fig.18 and Fig.26 )。The liquid inlet 2025 can be located between the liquid drainage element 2027 and the sealing element 2028.

[0242] Meanwhile, the sealing element, the liquid discharging element, and the connecting rod are of a hollow structure, and an accommodation cavity 2029 is included inside to collect excess liquid samples. During use, first, the opening of the first cavity collects the liquid sample. As the liquid sample enters, it accumulates at the bottom of the first cavity and then contacts the application area of the test element on the carrier for chemical analysis and detection. As the liquid increases, the liquid sample enters the second cavity through the opening 2091 of the connecting channel. Then, the liquid sample gradually fills the second cavity 204 and then submerges the first opening 2091 of the connecting channel. Eventually, the liquid level is higher than the first opening 2091 of the connecting channel 209. As the liquid continues to increase and reaches the set position, the collection of the liquid sample stops. Subsequently, the first cover 202 is used to cover the opening 2031 of the first cavity 203. As the cover closes the opening 2031 and rotates to close, it drives the sealing element 2028, the liquid discharging element 2027, and the liquid inlet 2025 of the liquid repellent channel close to the opening of the connecting channel 209 (as Fig. 22 , shown). As the cover rotates, the liquid discharging element 2027 first enters the connecting channel 209. At this time, the sealing ring of the sealing element has not approached the first opening 2091 of the connecting channel, and the first opening 2091 of the connecting channel is not sealed. The liquid can enter the first cavity 203 through the gap 809 between the liquid discharging element 2027 and the connecting channel 209. As the sealing element enters the connecting channel 209 to seal the connecting channel, the liquid discharged by the sealing element or the liquid discharging element enters the accommodation cavity 2029 through the liquid inlet 2025 of the liquid repellent channel, thereby discharging the excess liquid sample and reducing the pressure on the sealing element entering the connecting channel, making it easier to achieve a better seal. After the liquid discharging element enters the second cavity, at this time, the sealing element also seals the connecting channel 209. At this time, the test element in the detection cavity has completed the first or initial detection. If it is considered necessary to retain the remaining sample for secondary confirmation chemical analysis, the second cavity is rotated to separate it from the first cavity. Since the sealing element seals the connecting channel, the liquid sample in the first cavity will not leak out. Then, the second cover 201 provided on the first cover 202 is used to seal the opening 2042 of the second cavity 204 (as Fig.24 ). In this way, the second cavity can be stored separately or packaged and transported to a chemical analysis institution for secondary confirmation chemical analysis.

[0243] Embodiment 3

[0244] For example, in the device as Figure 25-Figure 30 shown, the device includes a first cavity 303 and a second cavity 304, and an opening 3031 for introducing a liquid sample in the first cavity 303. As Fig. 27 shown, the first cavity is surrounded by a side wall and a bottom, and a raised area is provided at the bottom of the first cavity. For example, as Fig. 27As shown, the raised area is located in the center of the entire bottom. An opening 3091 is provided in the raised area, and there is a connecting channel 309. The first opening 3091 of the connecting channel 309 communicates with the inside of the first chamber 303, and the other opening 3092 communicates with the opening 3042 of the second chamber. A groove is formed around the raised area inside the first chamber, and the groove forms liquid sample collection areas 3035, 3036 (such as Fig. 27 ). The outer wall and inner wall of the connecting channel 309 are smooth near the second opening 3092. There is a tray structure 1004, which has an internal thread 10041, and the internal thread is in threaded cooperation with the external thread at the bottom of the first chamber.

[0245] The second chamber 304 is located on a base tray 1004, and the base tray 1004 is detachably connected to the first chamber, and the second chamber 304 is also detachably combined with the base tray 1004. Specifically, the tray structure 1004 has an internal thread, and the internal thread is engaged with the external thread 3031 extending from the bottom of the first chamber 303, so as to realize the detachable combination of the tray structure 1004 and the first chamber 303. Thus, if there is still a connecting channel, such as Fig. 27 shown, the connecting channel 309 can still have a first opening 3091 in liquid flow with the first chamber and a second opening 3092 in liquid flow with the second chamber, and the connecting channel has an extension section 3098, which extends into the opening 3052 of the second chamber and contacts the inner wall of the opening 3041, and can be snap-fitted together, that is: the outer diameter of the extension area matches the inner diameter of the opening 3041. Although the second chamber and the first chamber can also be snap-fitted and connected through the connecting channel 109 as Fig. 27 shown, this connection does not require a very firm connection, and does not require a tight connection like Figure 8-Figure 9 shown (by means of threads, etc.), because the tray structure 1004 is engaged with the external thread 3031 of the extension section of the first chamber 103 through the thread 10041. In this way, no matter how much liquid sample the second chamber 304 collects, there will be no leakage problem between the connecting channel 109 and the opening 1042 of the second chamber. Therefore, the inner diameter of the connecting channel 109 can be smaller than the inner diameter of the opening 1042 of the second chamber, so that the connecting channel can be inserted into the opening 3042 of the second chamber, and this insertion method can be easily inserted ( Fig. 27 shown). And only threads are provided on the outer edge of the opening of the opening 3042 for the closing of the second cover (such as Fig. 27)。At this time, the connection between the connection channel and the opening of the second chamber only needs to ensure no leakage when collecting the liquid sample, that is, it can allow the liquid to enter the second chamber, and no more structural restrictions are required. This connection can be in the form of snap connection, piston type, or buckle. In fact, the detachable combination, joining, or engagement of the first chamber and the second chamber is completed in an indirect way.

[0246] After the collection is completed, after sealing the connection channel and / or performing the liquid discharge function of the second chamber according to the method described later, if a second confirmation test is required, separate the tray structure 1004 from the first chamber 103, for example, by reverse-rotating the threaded structure where the tray mates with the bottom of the first chamber. At this time, the second chamber 104 on the tray also separates from the first chamber 103 along with the tray structure, as Fig. 27 , at this time, remove the second cover 101 and cover the opening 3042 of the second chamber. Then separate the second chamber from the tray 1004 (as Fig.29 ), this is because there is a snap connection structure 10042 between the bottom of the second chamber and the bottom of the tray. Therefore, the tray and the second chamber will separate from the first chamber 103 together. Then, after detaching the tray 1004 from the second chamber 304, reconnect and combine the tray 1004 with the first chamber 103 separately again. At this time, the integrity of the first chamber is still maintained, and the second chamber can be sent to a confirmation testing institution for a second confirmation test. In order to make the second chamber 304 separate from the first chamber along with the movement of the tray, there is a snap ring 10042 on the tray. The shape of the snap ring is adapted to the shape of the cavity of the second chamber 304. For example, the cavity of the second chamber is U-shaped, and the snap ring 10042 is also U-shaped. In this way, when the tray structure 1004 rotates, it drives the second chamber 304 to rotate together. Since the second chamber and the snap ring can be slightly tightly fitted, naturally the second chamber 304 separates from the first chamber 303 together with the tray structure 1004. Of course, in some ways, the second chamber is a structure similar to a cube, and 4 buckle structures are provided on the tray to snap the second chamber and the buckle structures together, so as to realize the movement of the tray driving the movement of the second chamber, and further realize the separation of the second chamber from the first chamber.

[0247] A cover 302 is also provided. A connecting rod 3023 is connected to the center of the cover. A sealing element 3028 is provided at the end of the connecting rod. A sealing ring is provided on the sealing element. The sealing ring and the sealing element are made of the same material and are integrally injection-molded. At the same time, a liquid discharging element 3027 is provided under the sealing element. The liquid discharging element 3027, the sealing element and the connecting rod 3023 are integrally formed, and are only divided into different functional areas. Generally, the lengths of the connecting rod 3023, the sealing element 3038 and the liquid discharging element 3027 are slightly greater than the distance from the opening 3031 of the first chamber 303 to the opening 3042 of the second chamber 304. In this way, the liquid discharging element 3027 can enter the second chamber 304, so as to discharge part of the liquid sample in the second chamber. At the same time, a liquid inlet 3025 of the liquid drainage channel is provided under the sealing element 3028( Fig. 27 ). The liquid inlet 3025 can be located between the liquid discharging element 3027 and the sealing element 3028, or on the liquid discharging element. At the same time, the sealing element, the liquid discharging element and the connecting rod are of a hollow structure, and an accommodation chamber 3029 is included inside to collect the redundant liquid sample. When in use, first let the opening of the first chamber collect the liquid sample. As the liquid sample enters, it accumulates at the bottom of the first chamber. As the liquid increases, the liquid sample enters the second chamber through the opening 1091 of the connecting channel. Then, the liquid sample gradually fills the second chamber 304 and then submerges the first opening 3091 of the connecting channel. Finally, the liquid level is higher than the first opening 3091 of the connecting channel 309. At this time, stop collecting the liquid sample. Subsequently, cover the opening 3031 of the first chamber 303 with the first cover 302. As the cover closes the opening 3031, the rotation and closing of the cover drive the sealing element 3028, the liquid discharging element 3027 and the liquid inlet 3025 of the liquid drainage channel to approach the opening of the connecting channel 309. As the cover rotates, the liquid discharging element 3027 first enters the connecting channel 309. At this time, the sealing ring of the sealing element has not approached the first opening 3091 of the connecting channel. The liquid can enter the first chamber 303 through the gap between the liquid discharging element 3027 and the connecting channel 309. As the sealing element enters the connecting channel 309, the discharged liquid enters the accommodation chamber 3029 through the liquid inlet 3025 of the liquid drainage channel, so as to discharge the redundant liquid sample, and also reduces the pressure of the sealing element entering the connecting channel, so that it is easier to obtain a better seal. After the liquid discharging element enters the second chamber, at this time, the sealing element also seals the connecting channel 309.

[0248] At this time, the liquid in the first chamber can be used for subsequent initial detection. After deeming it necessary to retain the remaining sample for secondary confirmation testing, the tray structure is rotated to separate the tray structure from the first chamber, thereby driving the separation of the second chamber from the first chamber. Since the sealing element seals the connection channel, the liquid sample in the first chamber will not leak out. Then, the second cover 301 provided on the first cover 302 is used to seal the opening 3042 of the second chamber 304 (as Fig.28 ). At this time, the tray structure and the second chamber can be packaged together and sent to a testing institution for secondary testing. Alternatively, the second chamber can be removed from the tray and packaged for use in secondary confirmation testing ( Fig.29 ). At this time, the tray is rotated again onto the first chamber to form a complete structure ( Fig.30 ).

[0249] The following content of the present invention is also part of the technical solution of the present invention.

[0250] A device for collecting liquid samples includes: a first chamber for collecting liquid samples; and a second chamber for collecting samples used to confirm the detection of liquid samples; wherein, the first chamber and the second chamber are detachably combined, assembled or connected.

[0251] In the described device, the first chamber and the second chamber are in a state of liquid circulation.

[0252] In the described device, when the second chamber has not left the first chamber, the first chamber and the second chamber are in a state of liquid circulation.

[0253] In the described device, before the second chamber leaves the first chamber, or just before it is about to leave the first chamber, the first chamber and the second chamber are not in a state of liquid flow.

[0254] In the described device, the first chamber and the second chamber are assembled together in a detachable manner.

[0255] In the described device, the second chamber is located below the first chamber, or when collecting liquid, the liquid first enters the first chamber and then enters the second chamber, or the second chamber is downstream of the first chamber; or when collecting liquid, the liquid enters the first and second chambers simultaneously; or part of the liquid sample enters the first chamber and another part of the liquid sample enters the second chamber.

[0256] In the described device, the fluid circulation state between the first chamber and the second chamber includes one or more of the following states: fluid circulation, fluid non - circulation state.

[0257] The device described above, wherein the first chamber and the second chamber are first in a state where liquid does not flow, then in a state where liquid flows, and finally in a state where liquid does not flow.

[0258] The device described above, wherein the first chamber and the second chamber are first in a state where liquid flows, and then in a state where liquid does not flow.

[0259] The device described above, wherein when the first chamber and the second chamber are in a state where liquid flows, the first chamber and the second chamber are detachably combined together; or when the first chamber and the second chamber are in a state where liquid does not flow, the first chamber and the second chamber can be separated or have been separated.

[0260] The device described above, wherein when the first chamber and the second chamber are in a state where liquid does not flow, the first chamber and the second chamber are detachably combined together.

[0261] The device described above, wherein the device further includes a sealing element, which can change the liquid flow state between the first chamber and the second chamber; or the device further includes a puncturing element, which can change the state from a state where liquid does not flow to a state where liquid flows; or the device further includes a sealing element and a puncturing element, first allowing the puncturing element to make the first chamber and the second chamber in a state where liquid flows, and then making the liquid in a state where it does not flow through the sealing element.

[0262] The device described above, wherein the sealing element makes the first chamber and the second chamber not in a state where liquid flows before the second chamber leaves the first chamber, or before or about to separate from the first chamber.

[0263] The device described above, the device further includes a connecting channel, the second chamber is detachably combined, assembled or put together with the first chamber through the connecting channel, and / or the second chamber and the first chamber are in a state of liquid communication or not in a state of liquid communication through the connecting channel.

[0264] The device described above, wherein the device further includes a connecting channel; the second chamber and the first chamber are in liquid communication through the connecting channel.

[0265] The device described above, wherein when the second chamber has not left the first chamber, the connecting channel is not sealed; or before or after the second chamber leaves the first chamber, the connecting channel is sealed.

[0266] The device described above, wherein the connecting channel is sealed by a sealing element.

[0267] The device described above, wherein the device further includes a sealing element, which is used to seal the channel so that the first chamber and the second chamber are not in a state where liquid flows.

[0268] The device described above, wherein the device further comprises a liquid drainage channel which has a liquid inlet.

[0269] The device, or the liquid inlet is located below the sealing element, or when the sealing element seals the channel, the liquid inlet approaches the connecting channel prior to the sealing element, or when the sealing element enters the connecting channel, the liquid inlet is located below the horizontal position of the sealing element; or when the sealing element enters the connecting channel, the liquid inlet enters the connecting channel prior to the sealing element.

[0270] The device described above, wherein the liquid inlet is located on the sealing element.

[0271] The device described above, wherein the liquid inlet is located on the side wall of the connecting channel.

[0272] The device described above, wherein the liquid drainage channel further has a liquid outlet which is in liquid communication with a receiving cavity.

[0273] The device described above, wherein the receiving cavity is located on the sealing element.

[0274] The device described above, wherein the liquid drainage channel further has a liquid outlet which is in fluid communication with a first cavity.

[0275] The device described above, wherein the device further comprises a liquid drainage element for discharging a part of the liquid sample in the second cavity.

[0276] The device described above, wherein before the second cavity is separated from the first cavity, the liquid drainage element is located in the second cavity or partially located in the second cavity.

[0277] The device described above, wherein after the second cavity is separated from the first cavity, the second cavity does not contain the liquid drainage element or does not contain a part of the liquid drainage element.

[0278] The device described above, wherein the device further comprises a liquid drainage element for discharging a part of the liquid sample in the second cavity; the liquid drainage element is located on the sealing element or is integrated with the sealing element;

[0279] The device described above, wherein the liquid drainage element enters the connecting channel prior to the sealing element, or the liquid drainage element enters the second cavity prior to the sealing element; or when the sealing element is located in the connecting channel, the liquid drainage element is located in the second cavity.

[0280] The device described above, wherein the device further comprises a liquid drainage channel which has a liquid inlet, and the liquid inlet is located on the liquid drainage element; or the device comprises a receiving cavity which is located on the liquid drainage element.

[0281] In the device, the liquid inlet is in liquid communication with a receiving chamber, and the receiving chamber is located in the liquid discharge element.

[0282] The device, wherein a partial area of ​​the sealing element is used as a drainage element for draining part of the liquid in the second cavity.

[0283] The device, wherein the partial sealing element is used to seal the connecting channel, and the partial sealing element is used to discharge part of the liquid in the second chamber.

[0284] The device, wherein the partial sealing element is used to seal the connecting channel, and the partial sealing element is located in the second cavity.

[0285] The device, wherein the vertical projection area of ​​the drainage element is located within the vertical projection area of ​​the sealing element.

[0286] The device, wherein the device further comprises a liquid-repelling channel, the liquid-repelling channel has a liquid inlet, and the vertical projection of the liquid inlet is located within the vertical projection area of ​​the sealing element.

[0287] The device described above further comprises first and second sealing elements, wherein the first sealing element or the second sealing element can change the liquid flow state between the first chamber and the second chamber.

[0288] The device, wherein the first sealing element is used to seal the connecting channel, and the second sealing element is used to seal the opening of the second cavity, or the first sealing element is used to seal the opening of the second cavity, and the second sealing element is used to seal the first opening of the connecting channel.

[0289] The device, wherein, when the opening of the second cavity is sealed by the first sealing element or after the sealing, the position of the second cavity is changed from the first position to the second position; or the second cavity is separated from the first cavity.

[0290] The device, wherein the sealing element or the drainage element is moved in conjunction with each other.

[0291] The device, wherein the linkage is used to cover the first cavity opening cover body for movement.

[0292] The device described herein, wherein the movement is rotational movement.

[0293] A method for collecting a liquid sample, the method comprising:

[0294] Provided is a collection device, which includes a first chamber for collecting a liquid sample and a second chamber for collecting the liquid sample, wherein the first chamber and the second chamber are combined, joined or assembled in a detachable manner; before collecting the liquid sample, the first chamber and the second chamber are in a liquid communication state, so that the liquid entering the first chamber can flow into the second chamber.

[0295] The method as described above, wherein, after the first chamber has collected the liquid sample, the first chamber and the second chamber are not in a liquid communication state.

[0296] The method as described above, wherein, when the first chamber and the second chamber are not in a liquid communication state, the second chamber is separated from the first chamber, or the first chamber is separated from the second chamber.

[0297] The method as described above, wherein the liquid sample entering the second chamber is derived from the liquid sample in the first chamber; the liquid enters the first and second chambers simultaneously; or, part of the liquid sample enters the first chamber and another part of the liquid sample enters the second chamber.

[0298] The method as described above, wherein the first chamber and the second chamber are connected by a connection channel, wherein the second chamber is detachably combined, joined or assembled with the connection channel; or, through the connection channel, the first chamber and the second chamber are in a liquid communication state.

[0299] The method as described above, making the first chamber and the second chamber not in a liquid communication state is achieved by sealing the channel with a sealing element.

[0300] The method as described above, the channel has a first opening in fluid communication with the first chamber and a second opening in fluid communication with the second chamber, and the sealing element seals the first opening of the connection channel.

[0301] The method as described above, wherein, after the sealing element seals the first opening of the connection channel, part of the sealing element enters the channel.

[0302] The method as described above, wherein the device further includes a liquid drainage channel, and the liquid drainage channel includes a liquid inlet.

[0303] The method as described above, wherein, when part of the sealing element enters the channel, the liquid sample discharged by the sealing element is discharged out of the connection channel or out of the second chamber through the liquid inlet, if there is a liquid sample.

[0304] The method as described above, wherein the liquid sample discharged by the sealing element is discharged into the receiving chamber through the liquid drainage channel.

[0305] The method as described above, wherein the device further includes a liquid drainage channel, and the liquid drainage channel includes a liquid inlet, and the liquid inlet enters the connection channel prior to the sealing element.

[0306] The method described above, wherein the device further comprises a liquid discharging element for discharging a part of the liquid in the second chamber.

[0307] The method described above, wherein when there is a sealing element, the liquid discharging element enters or approaches the connection channel before the sealing element.

[0308] The method described above, wherein the liquid discharging element enters the second chamber or a part of the liquid discharging element enters the second chamber.

[0309] The method described above, wherein when the second chamber is separated from the first chamber, the liquid discharging element is not located in the second chamber.

[0310] The method described above, wherein when the sealing element seals the first opening of the connection channel, the liquid discharging element enters the second chamber; or when the sealing element enters the connection channel, the liquid discharging element enters the second chamber.

[0311] The method described above, wherein the sealing element and the liquid discharging element move in a linked manner.

[0312] The method described above, wherein the linkage is through the cover body covering the first chamber.

[0313] A device for collecting a liquid sample comprises: a first chamber for collecting a liquid sample; and a second chamber for collecting a liquid sample for confirming the detection of the liquid sample; wherein the first chamber has an opening for receiving the liquid sample, and the second chamber has an opening for receiving the liquid sample from the first chamber.

[0314] The device described above, wherein the device further comprises a tray structure, the second chamber is detachably arranged on the tray structure, and the tray structure is detachably combined with the first chamber.

[0315] The device described above, wherein when the tray structure is combined with the first chamber, the second chamber and the second chamber are in a liquid communication state.

[0316] The device described above, wherein the first chamber comprises a hole which is in a liquid communication state with the opening of the second chamber; or the liquid sample in the first chamber can flow into the second chamber by the action of gravity of the liquid itself.

[0317] The device described above, wherein the hole is the first opening of the connection channel, and the second chamber realizes a fluid communication state with the first chamber through the connection channel; or the hole has an extended channel, and the second chamber realizes a fluid communication state with the first chamber through the extended channel.

[0318] The device described above, wherein the connecting channel or the extending channel has a first opening and a second opening, the first opening is in fluid communication with the first chamber, and the second opening is in fluid communication with the second chamber.

[0319] The device described above, wherein the device further comprises a sealing element for sealing the connecting channel, the extending channel or the hole.

[0320] The device described above, wherein the sealing element can seal by sealing the first opening of the connecting channel or the extending channel or by allowing a part of the sealing element to enter the connecting channel or the extending channel.

[0321] The device described above, wherein the device further comprises a liquid-repellent channel.

[0322] The device described above, wherein the liquid-repellent channel includes a liquid inlet, the liquid inlet is located below the sealing element, or when the sealing element seals the connecting channel or the extending channel, the liquid inlet approaches the connecting channel or the extending channel prior to the sealing element, or when the sealing element enters the connecting channel or the extending channel, the liquid inlet is located below the horizontal position of the sealing element; or when the sealing element enters the connecting channel, the liquid inlet enters the connecting channel prior to the sealing element.

[0323] The device described above, wherein the device further comprises a liquid-repellent channel, the liquid-repellent channel includes a liquid inlet, and the projection area of the liquid inlet is located within the projection area of the sealing element.

[0324] The device described above, wherein the liquid inlet is located on the sealing element.

[0325] The device described above, wherein the liquid inlet is located on the side wall of the connecting channel.

[0326] The device described above, wherein the liquid inlet is lower than the position of the opening of the connecting channel

[0327] The device described above, wherein the liquid-repellent channel further has a liquid outlet, and the liquid outlet is in fluid communication with a receiving chamber.

[0328] The device described above, wherein the receiving chamber is located on the sealing element.

[0329] The device described above, wherein the liquid-repellent channel further has a liquid outlet, and the liquid outlet is in fluid communication with the first chamber

[0330] The device described above, wherein the device further comprises a liquid-repellent channel, the liquid-repellent channel includes a liquid inlet, and part of the liquid forced by the sealing element enters the liquid-repellent channel through the liquid inlet, and is thus discharged outside the channel and / or the second chamber.

[0331] The device described herein comprises a liquid discharge element for discharging part of the liquid sample in the second chamber.

[0332] The device, wherein the device further comprises a liquid-repelling channel, the liquid-repelling channel comprises a liquid inlet, and the liquid inlet is located on the liquid discharge element.

[0333] The device, wherein the drainage element and the sealing element are connected as an integral structure, when there is a sealing element.

[0334] The device described above, wherein when the sealing element is used to seal the channel, the drainage element enters the second chamber before the sealing element.

[0335] In the device, the liquid-repellent channel comprises a liquid outlet, and the liquid outlet is in liquid communication with a receiving chamber.

[0336] In the device, when part of the sealing element enters the connecting channel, the receiving chamber is used to receive the liquid sample discharged by the sealing element entering the connecting channel.

[0337] The device, wherein the receiving chamber is located in the sealing element or the drainage element.

[0338] The device described herein, wherein the projection area of ​​the drainage element is located within the vertical projection area of ​​the sealing element.

[0339] The device described herein, wherein the transverse diameter of the drainage element is smaller than the transverse diameter of the sealing element.

[0340] The device, wherein the connecting channel is cylindrical and the sealing element is also cylindrical.

[0341] The device further comprises a first cover body for covering the opening of the first cavity.

[0342] The device, wherein the cover body moves in conjunction with the sealing element, the latter the cover body moves in conjunction with the drainage element, or the cover body, the sealing element and the drainage element move in conjunction with each other.

[0343] The device, wherein when the first cover body covers the first cavity opening, the sealing element seals the first opening of the connecting channel or part of the element enters the connecting channel as the cover body is closed.

[0344] The device further comprises a liquid discharge element, wherein the liquid discharge element is connected to the sealing element.

[0345] The device, wherein the drainage element is further away from the first cover body than the sealing element.

[0346] The device described above, wherein the sealing element is connected to the first cover through a connecting rod.

[0347] The device described above, wherein the sealing element is detachably connected to the connecting rod.

[0348] The device described above, wherein the device further includes a liquid drainage channel, the liquid drainage channel includes a liquid inlet, and the projection area of the liquid inlet is located within the projection area of the sealing element.

[0349] The device described above, wherein the liquid inlet is farther from the first cover than the sealing element.

[0350] The device described above, wherein the liquid inlet is located on the liquid drainage element.

[0351] The device described above, wherein when the sealing element seals the connection channel, the liquid drainage element or a part of the liquid drainage element is located in the second chamber.

[0352] A method for collecting liquid: The method includes:

[0353] Providing a device for collecting a liquid sample, wherein the device includes: a first chamber for collecting the liquid sample, wherein the first chamber has an opening for receiving the liquid sample; and

[0354] A second chamber for collecting a liquid sample for confirming the detection, the second chamber having an opening for receiving the liquid sample from the first chamber;

[0355] A tray structure, the tray structure includes the second chamber, wherein the tray structure is detachably combined, joined or assembled with the first chamber;

[0356] Using the first chamber to collect the liquid sample, and allowing the liquid sample to enter the first chamber through the opening of the first chamber.

[0357] The method described above, wherein the first chamber has a hole, and the hole forms a liquid flow with the second chamber.

[0358] The method described above, wherein before collecting the liquid, the first chamber and the second chamber are made to be in a liquid communication state through the hole.

[0359] The method described above, wherein when collecting the liquid, allowing the liquid to enter the first chamber, and then allowing the liquid to automatically flow from the first chamber through the hole into the second chamber; or, allowing the liquid to enter the first chamber and the second chamber simultaneously; or, allowing part of the liquid to enter the first chamber and another part of the liquid to enter the second chamber.

[0360] The method described above, wherein the hole has an extended channel, and a part of the extended channel is located in the second chamber, or the opening of a part of the second chamber is located in the part of the channel, thereby forming a liquid connection.

[0361] The method described above, wherein after the liquid sample collection is completed, a sealing element is used to seal the hole or the extended channel, so that the second chamber and the first chamber are not in fluid connection.

[0362] The method described above, wherein after the second chamber and the first chamber are not in fluid connection, the tray is removed from the first cavity, thereby driving the second chamber away from the first chamber.

[0363] The method described above, wherein the second chamber is detached from the tray.

[0364] The method described above, wherein before or after the second chamber is detached from the tray, the opening of the second chamber is covered with a second cover to form a sealed second chamber.

[0365] The method described above, wherein a first cover for covering the opening of the first chamber is provided, and the sealing element is arranged on the cover, and the cover and the sealing element are driven to move in linkage.

[0366] The method described above, wherein when covering the opening of the first chamber, the cover drives the sealing element to prevent liquid from flowing between the first chamber and the second chamber.

[0367] The method described above, wherein the cover drives the sealing element to seal the hole or the extended channel between the first chamber and the second chamber.

[0368] The method described above, wherein the cover drives the sealing element to make a part of the sealing element enter the extended channel.

[0369] The method described above, wherein the cover further includes a liquid discharge element, and the liquid discharge element is farther from the cover than the sealing element.

[0370] The method described above, wherein the cover further includes a liquid repellent channel, and the liquid repellent channel includes a liquid inlet, and the position of the liquid inlet is farther from the cover than the sealing element; or the liquid inlet enters the extended channel before the sealing element.

[0371] The method described above, wherein the projection area of the liquid inlet is located within the projection area of the sealing element.

[0372] The method described above, wherein a part of the liquid forced by the sealing element enters the liquid repellent channel through the liquid inlet and is thus discharged outside the channel and / or the second chamber.

[0373] The method described above, wherein the hydrophobic channel includes a liquid outlet, and the liquid outlet is in fluid communication with a receiving cavity.

[0374] The method described above, wherein the receiving cavity is located in the sealing element, or the liquid discharging element, or the cover body.

[0375] The method described above, wherein when a part of the sealing element enters the connecting channel, the receiving cavity is used to receive the liquid sample discharged by the sealing element entering the connecting channel.

[0376] The method described above, wherein when the liquid discharging element enters the second cavity, a part of the liquid sample discharged by the liquid discharging element enters the receiving cavity.

[0377] A detection device for detecting an analyte in a sample includes: a first cavity for collecting a liquid sample; and a second cavity for collecting a liquid sample for confirming the detection of the liquid sample, wherein the first cavity has an opening for receiving the liquid sample, the second cavity has an opening for receiving the liquid sample from the first cavity, and wherein the device further includes a test element.

[0378] The device described above, wherein the device further includes a tray structure, the tray structure is detachably connected to the first cavity, wherein the second cavity is provided on the tray, and the second cavity is detachably combined, assembled or connected to the first cavity through the tray.

[0379] The device described above, wherein the second cavity is in a fluid communication state with the first cavity through a channel.

[0380] The device described above, wherein the channel has a first opening and a second opening, the first opening is in fluid communication with the first cavity, and the second opening is in fluid communication with the second cavity.

[0381] The device described above, wherein the device further includes a sealing element for sealing the connecting channel.

[0382] The device described above, wherein the sealing element for sealing the connecting channel can seal by sealing the first opening of the channel or a part of the sealing element entering the connecting channel.

[0383] The device described above, wherein the device further includes a hydrophobic channel, the hydrophobic channel includes a liquid inlet and a liquid outlet, and the liquid inlet is located in the area below the sealing element.

[0384] The device described above, wherein the device further includes a hydrophobic channel, the hydrophobic channel includes a liquid inlet and a liquid outlet, and the projection area of the liquid inlet is within the projection area of the sealing element.

[0385] The device described above, wherein the device further includes a liquid discharge element for discharging a part of the liquid in the second chamber, and the liquid discharge element is connected to the sealing element.

[0386] The device described above, wherein the device further includes a liquid repellent channel, the liquid repellent channel includes a liquid inlet, and the liquid inlet is located on the liquid discharge element.

[0387] The device described above, wherein the liquid repellent channel includes a liquid outlet, the liquid outlet is in liquid communication with the liquid in the receiving chamber, and the receiving chamber is used to structure the liquid discharged by the liquid discharge element.

[0388] The device described above, wherein when a part of the sealing element enters the channel, the receiving chamber is used to receive the liquid sample discharged by the sealing element entering the connecting channel.

[0389] The device described above, wherein the receiving chamber is located in the sealing element or the liquid discharge element.

[0390] The device described above, wherein the projected area of the liquid discharge element is located within the vertical projected area of the sealing element.

[0391] The device described above, wherein the transverse diameter of the liquid discharge element is smaller than the transverse diameter of the sealing element.

[0392] The device described above, wherein the connecting channel is cylindrical, and the sealing element is also cylindrical.

[0393] The device described above, wherein the device further includes a first cover for covering the opening of the first chamber, and the sealing element is provided on the cover, so that when the first cover covers the opening of the first chamber, the sealing element seals the first opening of the connecting channel or a part of the element enters the connecting channel as the cover is closed.

[0394] The device described above, wherein the device further includes a liquid discharge element, and the liquid discharge element is connected to the sealing element.

[0395] The device described above, wherein the liquid discharge element is farther from the first cover than the sealing element.

[0396] The device described above, wherein the sealing element is connected to the first cover through a connecting rod.

[0397] The device described above, wherein the sealing element is detachably connected to the connecting rod.

[0398] The device described above, wherein the device further includes a liquid repellent channel, the liquid repellent channel includes a liquid inlet, and the projected area of the liquid inlet is located within the projected area of the sealing element.

[0399] The device described above, wherein the liquid inlet is farther from the first cover than the sealing element.

[0400] The device described above, wherein the liquid inlet is located on the liquid discharge element.

[0401] The device described above, wherein when the sealing element seals the channel, the liquid discharge element or a part of the liquid discharge element is located in the second chamber.

[0402] The device described above, further comprising a detection chamber fluidly connected to the first chamber, and the test element is located in the detection chamber.

[0403] The device described above, further comprising a carrier on which there are a plurality of channels for accommodating test elements, and the carrier is located in the first chamber.

[0404] The device described above, wherein the sample application area of the test element is located at the bottom of the first chamber.

[0405] A chamber for collecting liquid samples, characterized in that the chamber comprises:

[0406] Side walls;

[0407] A bottom; and an opening for receiving liquid, wherein the bottom has a hole for allowing the liquid sample entering the chamber to flow out of the chamber.

[0408] There is a raised area on the bottom of the chamber, and the raised area and the side walls form a liquid sample collection area.

[0409] The sample collection area is configured to receive a test carrier.

[0410] The test carrier includes test elements.

[0411] The raised area includes the hole.

[0412] The hole has an extending channel.

[0413] The channel extends into the chamber and / or extends out of the chamber.

[0414] The channel extends out of the chamber.

[0415] The raised area has a platform structure in the chamber, and the platform structure includes the hole.

[0416] The chamber further comprises an extending area at the bottom, and the length of the extending area exceeds or is equal to the length of the extending channel.

[0417] The position of the hole is higher than the bottom of the collection area, or when collecting liquid, the liquid first reaches the collection area and then flows into the hole.

[0418] A cover, the cover includes a sealing element.

[0419] The cover is for covering the opening of the cavity.

[0420] The cover further includes a connecting rod structure, one end of the connecting rod is connected to the cover, and the other end is connected to the sealing element.

[0421] The sealing element is the end of a part of the connecting rod, or the sealing element and the connecting rod are of an integral structure.

[0422] The sealing element is made of an elastic material.

[0423] The sealing element and the connecting rod are detachably connected.

[0424] The sealing element and the connecting rod are connected by plugging, threading, or snap-fastening.

[0425] The sealing element and the connecting rod are of a hollow structure.

[0426] The sealing element and the connecting rod are integrally injection-molded.

[0427] The sealing element includes a sealing ring.

[0428] The material of the sealing ring and the sealing element is the same, or the sealing element containing the sealing ring is integrally injection-molded.

[0429] A cover, the cover includes a sealing element and a liquid discharging element.

[0430] The cover is for covering the opening of the cavity.

[0431] The cover further includes a connecting rod structure, one end of the connecting rod is connected to the cover body, and the other end is connected to the sealing element and the liquid discharging element.

[0432] The sealing element is the end of a part of the connecting rod, or the sealing element and the connecting rod are of an integral structure.

[0433] The sealing element is made of an elastic material.

[0434] The sealing element is connected to the liquid discharging element.

[0435] The liquid discharging element is farther from the cover body than the sealing element.

[0436] The vertical projection of the liquid discharging element is within or overlaps the vertical projection area of the sealing element.

[0437] The transverse diameter of the liquid discharge element is smaller than that of the sealing element.

[0438] The liquid discharge element has a conical shape.

[0439] One of the sealing element, the connecting rod, and the liquid discharge element includes a hollow cavity, or the sealing element, the connecting rod, and the liquid discharge element are all of hollow structures.

[0440] A cover body, the cover body includes a sealing element, a liquid discharge element, and a receiving cavity.

[0441] The cover body further includes a connecting rod structure, one end of the connecting rod is connected to the cover body main body, and the other end is connected to the sealing element and the liquid discharge element.

[0442] The sealing element is the end of a partial connecting rod, or the sealing element and the connecting rod are of an integral structure.

[0443] The sealing element is made of an elastic material.

[0444] The sealing element is connected to the liquid discharge element.

[0445] The liquid discharge element is farther from the cover body main body than the sealing element.

[0446] One of the sealing element, the connecting rod, and the liquid discharge element includes a hollow cavity, or the sealing element, the connecting rod, and the liquid discharge element are of multiple hollow structures, and the receiving cavity is a partial hollow cavity or a hollow structure.

[0447] The transverse diameter of the liquid discharge element is smaller than that of the sealing element.

[0448] The liquid discharge element has a conical shape.

[0449] The receiving cavity is located in the connecting rod, the sealing element, or the liquid discharge element.

[0450] A cover body, the cover body includes a sealing element and a liquid drainage channel, and the liquid drainage channel includes a liquid inlet and a liquid outlet.

[0451] The cover body further includes a connecting rod structure, one end of the connecting rod is connected to the cover body main body, and the other end is connected to the sealing element.

[0452] The liquid inlet of the liquid drainage channel is farther from the cover body main body than the sealing element.

[0453] The sealing element is connected to the liquid discharge element.

[0454] The liquid inlet of the liquid drainage channel is located on the liquid discharge element.

[0455] The described sealing element includes a sealing ring, and the liquid inlet of the liquid drainage channel is farther from the main body of the cover than the sealing ring.

[0456] The cover further includes a receiving cavity, wherein the liquid outlet of the liquid drainage channel is in fluid communication with the receiving cavity.

[0457] One of the sealing element, the connecting rod, and the liquid drainage element includes a hollow cavity, or the sealing element, the connecting rod, and the liquid drainage element are of a multi-hollow structure, and the liquid outlet of the liquid drainage channel is in fluid communication with the hollow cavity or the hollow structure.

[0458] The liquid outlet of the liquid drainage channel is farther from the main body of the cover than the sealing element.

[0459] The vertical projection of the liquid drainage element is within or overlaps the vertical projection area of the sealing element.

[0460] A device for collecting liquid samples, which includes a first cavity and a second cavity. Wherein, a protruding area protruding into the cavity is provided at the bottom of the cavity, and the protruding area forms a space protruding relative to the first cavity, thereby forming a space sunken relative to the bottom, and a part of the second cavity is located within the sunken area.

[0461] The first cavity includes holes, and the holes and the opening of the second cavity are in a liquid flow state.

[0462] The device further includes a connecting channel, and the second cavity forms a detachable combination, union or assembly with the connecting channel.

[0463] The opening of the second cavity includes an external thread, and the connecting channel includes an internal thread, and the external thread of the second cavity and the internal thread of the connecting channel are combined, united or assembled by threads.

[0464] The hole has an extended channel, and the extended section is a part of the connecting channel, wherein the extended channel is located within the sunken space.

[0465] A part of the extended channel is located within the second cavity.

[0466] The outer diameter of a part of the extended channel is equal to or smaller than the inner diameter of the opening of the second cavity.

[0467] The extended channel is inserted into the second cavity.

[0468] The device further includes a connecting channel, the hole is the first opening of the connecting channel, the first opening is in fluid communication with the first cavity, and the second cavity is in fluid communication with the second opening of the connecting channel.

[0469] The device further includes a tray structure, the second chamber is detachably disposed on the tray structure, and the tray structure is detachably combined with the first chamber.

[0470] A chamber for collecting a fluid sample, characterized in that the chamber comprises:

[0471] Side walls;

[0472] A bottom; and an opening for receiving liquid, wherein the bottom has an opening for allowing the liquid sample entering the chamber to flow out of the chamber, and wherein the device further includes a detection chamber for placing a test element, and the detection chamber is in liquid communication with the chamber through a through hole.

[0473] The position of the opening is higher than the position of the through hole, or the opening is closer to the opening of the chamber than the through hole; or the through hole is closer to the bottom of the chamber than the opening.

[0474] When the chamber collects a liquid sample, the liquid first enters the through hole and then enters the opening, or part of the liquid sample enters the through hole and part of the liquid sample enters the opening.

[0475] The opening includes a channel extending outward from the bottom.

[0476] There is a region protruding into the chamber at the bottom of the chamber, and the protruding region and the side wall form a liquid sample collection region.

[0477] The collection region includes a bottom, and the opening is higher than the bottom position of the collection region.

[0478] The bottom of the collection region is a bottom region of a part of the chamber.

[0479] The detection chamber includes a test element.

[0480] The test element is located on a carrier, and the carrier is located in the detection chamber.

[0481] The test element includes a sample application region for contacting the liquid sample in the detection quantity.

[0482] A device for collecting a liquid sample, the device comprising: a first chamber and a second chamber for collecting a liquid sample, the second chamber further includes a detection chamber for primary detection that is in fluid communication with the second chamber, wherein the bottom of the first chamber has an opening, and the opening is sealed by a sealing element.

[0483] The first chamber and the second chamber are detachably combined, joined or assembled.

[0484] The sealing element is a pierceable sealing element.

[0485] The described sealing element is one or several of plastic film, double-sided tape, single-sided tape, and aluminum foil.

[0486] The described opening has a channel extending outward, and the channel includes a second opening in fluid communication with the second chamber.

[0487] The described device further includes a piercing element and / or another sealing element for piercing the sealing element.

[0488] The described device further includes another sealing element, which is used to seal the opening after the piercing element pierces the sealing element.

[0489] The piercing element and the other sealing element are arranged on the first cover body, and the first cover body is used to cover the opening of the first chamber.

[0490] The piercing element is farther from the body of the cover than the other sealing element.

[0491] The piercing element and the other sealing element are arranged such that the piercing element first pierces the sealing element of the sealed opening, then releases part of the liquid into the second chamber, and then the other sealing element seals the opening.

[0492] The described device further includes a second cover body for sealing the second opening of the channel.

[0493] All patents and publications mentioned in the specification of the present invention indicate that these are publicly known technologies in the field and can be used in the present invention. All patents and publications cited herein are listed in the references in the same way as each individual publication is specifically referenced. The present invention described herein can be implemented in the absence of any one or more elements, one or more limitations, and such limitations are not specifically described here. For example, in each instance here, the terms "comprising", "consisting essentially of", and "consisting of" can be replaced by the other two of the three terms. The so-called "a" here only means "one", and does not exclude including only one, nor does it exclude including more than two. The terms and expressions used here are for descriptive purposes and are not limiting, and there is no intention here to indicate that these terms and interpretations described in this book exclude any equivalent features, but it can be understood that any suitable changes or modifications can be made within the scope of the present invention and the claims. It can be understood that the embodiments described in the present invention are all preferred embodiments and features, and any person of ordinary skill in the art can make some changes and variations based on the essence described in the present invention, and these changes and variations are also considered to be within the scope of the present invention and the scope limited by the independent claims and the dependent claims.

Claims

1. A detection device for detecting an analyte in a sample, comprising: A first chamber for collecting a liquid sample and performing a detection; And a second chamber for collecting a liquid sample for confirming the detected liquid sample, wherein the first chamber has an opening for receiving the liquid sample, and the second chamber has an opening for receiving the liquid sample from the first chamber. Further, the device further includes a test element located in the detection chamber; The bottom of the first chamber has a raised area located at the center of the entire bottom. An opening is provided in the raised area, and there is a connecting channel. The first opening of the connecting channel communicates with the inside of the first chamber, and the second opening communicates with the opening of the second chamber; A groove is formed around the raised area inside the first chamber, and this groove forms a liquid sample collecting area; The second chamber is detachably fitted with the first chamber through the connecting channel; At the same time, it further includes a detection chamber, and the detection chamber forms a liquid connection with the first chamber through a through hole; A narrow space is provided on the outer wall of the second opening of the connecting channel, and this narrow space can just be fitted with the opening of the second chamber to realize the combination of the first chamber and the second chamber; It further includes a first cover for covering the opening of the first chamber. A sealing element is provided on the first cover. Thus, when the first cover covers the opening of the first chamber, the sealing element seals the first opening of the connecting channel as the cover is closed; The sealing element is connected to the first cover through a connecting rod; It further includes a liquid discharging element for discharging part of the liquid in the second chamber. The liquid discharging element and the sealing element are connected together; It further includes a liquid draining channel, and the liquid draining channel includes a liquid inlet and a liquid outlet. The liquid inlet is located in the area below the sealing element; The position of the first opening of the connecting channel is higher than the height of the through hole, and the position of the liquid sample collecting area is lower than the position of the first opening of the connecting channel; It further includes a tray structure, and the tray structure is detachably connected to the first chamber. The second chamber is arranged on the tray, and the second chamber is detachably combined, assembled or connected to the first chamber through the tray; The projected area of the liquid inlet of the liquid draining channel is located within the projected area of the sealing element.

2. The device according to claim 1, wherein The liquid inlet is located on the liquid discharging element.

3. The device according to claim 2, wherein The liquid outlet of the liquid draining channel is in liquid communication with a receiving chamber, and the receiving chamber is used to receive the liquid discharged by the liquid discharging element.

4. The device according to claim 3, wherein When part of the sealing element enters the channel, the receiving chamber is used to receive the liquid sample discharged by the sealing element entering the connecting channel.

5. The device according to claim 4, wherein The receiving chamber is located in the sealing element or the liquid discharging element.

6. The device according to claim 5, wherein The projected area of the liquid discharging element is located within the vertical projected area of the sealing element.

7. The apparatus according to claim 6, wherein, The transverse diameter of the liquid discharging element is smaller than the transverse diameter of the sealing element.

8. The apparatus according to claim 7, wherein The connecting channel is cylindrical, and the sealing element is also cylindrical.

9. The apparatus according to claim 8, wherein, The liquid discharging element is farther from the first cover than the sealing element.

10. The device according to claim 9, wherein, The sealing element is detachably connected to the connecting rod.

11. The device according to claim 10, wherein, The liquid inlet of the liquid draining channel is farther from the first cover than the sealing element.

12. The apparatus according to claim 11, wherein, The liquid inlet is located on the liquid discharging element.

13. The device according to claim 12, wherein, When the sealing element seals the channel, the liquid discharging element or part of the liquid discharging element is located in the second chamber.

14. The device according to claim 13, wherein, The described device further includes a carrier, which includes a plurality of channels for accommodating test elements, and the carrier is located in the first cavity.

15. The apparatus according to claim 14, wherein, The sample application area of the test element is located at the bottom of the first cavity.

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