Fully automatic chemiluminescence analyzer

Abstract

The present invention relates to a fully automatic chemiluminescence analyzer, and relates to the technical field of chemiluminescence immunoassay, and is used to solve the technical problem of low sample delivery efficiency of the chemiluminescence analyzer in the prior art. The fully automatic chemiluminescence analyzer of the present invention comprises a track conveying mechanism and a sample rack temporary storage mechanism, and the track conveying mechanism conveys the untested sample rack in the sample rack temporary storage mechanism to the sample detection position of the host for detection, and after the host completes the corresponding operation, the sample rack can be transported back to the sample rack temporary storage mechanism to wait for the detection result, without waiting for the detection result at the sample detection position, so that the sample conveying efficiency can be greatly improved, thereby improving the efficiency of sample delivery.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims the priority of Chinese patent application CN201811014098.0, entitled “Fully Automatic Chemiluminescence Analyzer”, filed on August 31, 2018, the entire contents of which are incorporated herein by reference. Technical Field

[0003] The invention relates to the technical field of chemiluminescence immunoassay, and in particular to a fully automatic chemiluminescence analyzer. Background Art

[0004] Chemiluminescent immunoassay is a non-radioactive immunoassay technology that has developed rapidly in recent years. Its principle is to use chemiluminescent substances to amplify signals and directly measure the immune binding process with the help of its luminescence intensity. This method has become one of the important directions of immunological detection. In existing chemiluminescent analyzers, after the track sampling module sends the sample rack to the sample detection position, it must wait until the sample detection is completed before it can be sent away from the sample detection position and the next batch of samples can be transported, resulting in low sample delivery efficiency. Summary of the invention

[0005] The invention provides a fully automatic chemiluminescence analyzer, which is used to solve the technical problem of low sample delivery efficiency of the chemiluminescence analyzer in the prior art.

[0006] The present invention provides a fully automatic chemiluminescence analyzer, comprising a host, which is used to obtain a sample located at a sample detection position and detect the sample;

[0007] A track conveying mechanism is used to convey the sample rack carrying the sample.

[0008] A sample rack temporary storage mechanism, located at one side of the mainframe and used for storing the sample rack;

[0009] Among them, the first end of the track conveying mechanism is connected to the sample rack temporary storage mechanism, and the second end of the track conveying mechanism corresponds to the sample detection position of the host. The track conveying mechanism transports the sample rack in the sample rack temporary storage mechanism to the sample detection position, and transports the sample rack back to the sample rack temporary storage mechanism after the host completes the corresponding operation.

[0010] In one embodiment, the track conveying mechanism includes a detection track and a retraction track, the first end of the detection track is connected to the output end of the sample rack temporary storage mechanism, the first end of the retraction track is connected to the input end of the sample rack temporary storage mechanism, the second end of the detection track is connected to the second end of the retraction track, the second end of the retraction track corresponds to the sample detection position of the host, and after the host completes the operation on the sample rack at the second end of the retraction track, the retraction track transports the sample rack back to the sample rack temporary storage mechanism.

[0011] In one embodiment, the sample rack temporary storage mechanism includes a to-be-tested portion, an inspected portion, and a turnover portion which are arranged in sequence, the output end of the to-be-tested portion is connected to the first end of the detection track, the input end of the turnover portion is connected to the first end of the push-back track, and the output end of the turnover portion is respectively connected to the input ends of the to-be-tested portion and the inspected portion.

[0012] The present invention provides a track changing mechanism for a fully automatic chemiluminescence analyzer. The track changing mechanism is arranged at the second end of a detection track and transfers a sample rack at the second end of the detection track to the second end of a push-back track.

[0013] In one embodiment, the track changing mechanism comprises a fork plate slidably arranged above the detection track and the push-back track, and a slot body for accommodating the sample rack is arranged on the fork plate.

[0014] In one embodiment, the track changing mechanism includes a first transmission part and a first sensing part which are electrically connected, the fork plate is connected to the first transmission part, and the first sensing part is used to detect whether the sample rack at the second end of the detection track is completely in place.

[0015] In one embodiment, the first transmission part includes a first belt, a first slider clamped on the first belt, and a first slide rail, the fork plate is connected to the bottom of the first slider, and when the first belt is driven, the first slider drives the fork plate to move along the first slide rail.

[0016] In one embodiment, a second sensing portion electrically connected to the first transmission portion is disposed at the end of the first slide rail, and the second sensing portion is used to detect whether the fork plate is located directly above the detection track.

[0017] In one embodiment, the second sensing unit is a photoelectric sensor.

[0018] In one embodiment, a first light shielding sheet is disposed on a side of the first sliding block.

[0019] In one embodiment, the running direction of the first belt is perpendicular to the running direction of the detection track.

[0020] In one embodiment, the first transmission part includes a first motor for driving the first belt, and an output shaft of the first motor is parallel to the length direction of the detection track.

[0021] The present invention provides a recovery pusher for a fully automatic chemiluminescence analyzer, wherein the recovery pusher is arranged at the second end of a retracting track and enables a sample rack on the retracting track to move in a direction opposite to the running direction of a detection track.

[0022] In one embodiment, the recovery pusher moves the sample rack on the push-back track each time by a distance that is the center distance between two test tubes on the sample rack.

[0023] In one embodiment, the recovery push handle includes a second transmission part and a first transverse push plate connected to the second transmission part, and the first transverse push plate is parallel to the length direction of the retreat track.

[0024] In one embodiment, the width of the first lateral push plate is the same as the width of the sample rack.

[0025] In one embodiment, the second transmission part includes a second belt, a second slider clamped on the second belt, and a second slide rail, the first transverse push plate is connected to the top of the second slider, and when the second belt is driven, the second slider drives the first transverse push plate to move along the second slide rail.

[0026] In one embodiment, a third sensing portion is disposed at both ends of the second slide rail, and the third sensing portion is used to detect whether the first transverse push plate reaches a limit position.

[0027] In one embodiment, the third sensing unit is a photoelectric sensor.

[0028] In one embodiment, a second light shielding sheet is disposed on a side of the second sliding block.

[0029] In one embodiment, the second transmission part includes a second motor for driving the second belt, and an output shaft of the second motor is perpendicular to the length direction of the detection track.

[0030] In one embodiment, the first transverse push plate is an L-shaped plate structure.

[0031] The present invention provides a sample introduction pusher for a fully automatic chemiluminescence analyzer. The sample introduction pusher is arranged at the input end of a to-be-tested part and is used to push a sample rack in the to-be-tested part from the input end to the output end.

[0032] In one embodiment, the injection pusher includes a third transmission part and a longitudinal push plate, and the moving direction of the longitudinal push plate is perpendicular to the moving direction of the first transverse push plate.

[0033] In one embodiment, the third transmission part includes a third belt, a third slider clamped on the third belt, and a third slide rail. The longitudinal push plate is connected to the top of the third slider. When the third belt is driven, the third slider drives the longitudinal push plate to move along the third slide rail.

[0034] In one embodiment, fourth sensing parts are provided at both ends of the third slide rail, and the fourth sensing parts are used to detect whether the longitudinal push plate reaches the limit position.

[0035] In one embodiment, the fourth sensing unit is a photoelectric sensor.

[0036] In one embodiment, a third light blocking sheet is disposed on a side of the third sliding block.

[0037] In one embodiment, the third transmission part includes a third motor for driving a third belt, and an output shaft of the third motor is parallel to a width direction of the detection track.

[0038] In one embodiment, the longitudinal push plate is in the shape of an elongated strip.

[0039] In one embodiment, a pushing mechanism is provided on the top of the third sliding block, and the pushing mechanism is rotatably connected to the longitudinal pushing plate.

[0040] In one embodiment, the pushing mechanism includes a fixed seat fixedly connected to the third sliding block, and a lead screw arranged in the fixed seat, one end of the lead screw is connected to the rotating head, and the other end is provided with a push pin.

[0041] In one embodiment, a spring is further provided at the connection between the rotating head and the longitudinal push plate.

[0042] The present invention provides a push-back push handle for a fully automatic chemiluminescence analyzer, which is arranged at the end of a sample rack temporary storage mechanism and is used to push the sample rack at the output end of a turnover zone to the input end of a to-be-tested portion or the input end of a tested portion.

[0043] In one embodiment, the push-back handle includes a fourth transmission portion and a second transverse push plate, and a moving direction of the second transverse push plate is parallel to a moving direction of the second transverse push plate.

[0044] In one embodiment, both ends of the fourth transmission part are provided with fifth sensing parts, and the fifth sensing parts are used to detect whether the second transverse push plate reaches the limit position.

[0045] In one embodiment, the fifth sensing unit is a photoelectric sensor.

[0046] In one embodiment, a fourth light blocking sheet is disposed on a side of the fourth sliding block.

[0047] In one embodiment, the fourth transmission part includes a fourth motor for driving a fourth belt, and an output shaft of the fourth motor is parallel to the length direction of the detection track.

[0048] In one embodiment, the second transverse push plate is an L-shaped plate structure.

[0049] The present invention provides a downward moving pusher for a fully automatic chemiluminescence analyzer. The downward moving pusher is arranged at an input end of a tested part and is used to push a sample rack in the tested part downward from the input end.

[0050] In one embodiment, the downward push handle includes a fifth transmission part and a downward push plate, and the moving direction of the downward push plate is parallel to the length direction of the part to be inspected.

[0051] In one embodiment, the fifth transmission part includes a fifth motor, a fifth slider connected to the fifth motor, and a fifth slide rail, and the downward push plate is arranged at the upper end of the fifth slider.

[0052] In one embodiment, both ends of the fifth transmission part are provided with seventh sensing parts, and the seventh sensing parts are used to detect whether the downward push plate reaches the limit position.

[0053] In one embodiment, the seventh sensing unit is a photoelectric sensor.

[0054] In one embodiment, a fifth light blocking sheet is disposed on a side of the fifth sliding block.

[0055] In one embodiment, the output shaft of the fifth motor is parallel to the width direction of the inspection portion.

[0056] In one embodiment, the downward push plate is in the shape of a flat plate.

[0057] The present invention provides an upward pusher for a fully automatic chemiluminescence analyzer. The upward pusher is arranged at the input end of a circulation part and is used to push a sample rack in the circulation part from the input end to the output end.

[0058] In one embodiment, the upward push handle includes a sixth transmission part and an upward push plate, and the moving direction of the upward push plate is parallel to the length direction of the turnover part.

[0059] In one embodiment, the sixth transmission part includes a sixth belt, a sixth slider clamped on the sixth belt, and a sixth slide rail, and the upward push plate is arranged at the upper end of the sixth slider.

[0060] In one embodiment, both ends of the sixth transmission part are provided with an eighth sensing part, and the eighth sensing part is used to detect whether the upward push plate reaches the limit position.

[0061] In one embodiment, the eighth sensing unit is a photoelectric sensor.

[0062] In one embodiment, a sixth light blocking sheet is disposed on a side of the sixth sliding block.

[0063] In one embodiment, the sixth transmission part includes a sixth motor for driving a sixth belt, and an output shaft of the sixth motor is parallel to the height direction of the circulatory part.

[0064] In one embodiment, the upward push plate is a U-shaped plate.

[0065] In one embodiment, the to-be-tested portion, the tested portion and the turnover portion are all provided with running tracks, and a groove is provided at the bottom end of the sample rack, and the groove matches the running track.

[0066] In one embodiment, the detection track is a conveyor belt, and the push-back track is a slide groove arranged parallel to the conveyor belt.

[0067] In one embodiment, the track transport mechanism includes an emergency track, a first end of the emergency track is an input end or an output end, and a second end of the emergency track corresponds to an emergency sample introduction position of a host.

[0068] In one embodiment, the emergency track is a conveyor belt arranged parallel to the detection track.

[0069] In one embodiment, a sixth sensing portion is disposed at the second end of the emergency track, and the sixth sensing portion is used to detect whether the sample rack on the emergency track is completely in place.

[0070] In one embodiment, scanning units are provided on both the detection track and the emergency track.

[0071] In one embodiment, the host comprises an incubation module and a loading arm module disposed at a sample detection position, and the loading arm module transfers the sample at the sample detection position to a reaction cup in the incubation module for incubation.

[0072] In one embodiment, the loading arm module includes a support and an arm assembly, and the arm assembly is arranged on the upper part of the support.

[0073] In one embodiment, the host includes a detection module disposed above the incubation module. After the incubation is completed, the detection module performs optical excitation on the sample in the reaction cup and detects the luminescent signal generated after the excitation.

[0074] In one embodiment, the detection module includes an excitation unit for emitting excitation light and exciting the object to be detected and a detection unit for receiving and detecting a luminescent signal generated by the object to be detected.

[0075] In one embodiment, the excitation unit and the detection unit do not operate at the same time.

[0076] In one embodiment, the host comprises a cup-arranging module disposed behind the sample loading arm module and a cup-loading module disposed between the cup-arranging module and the incubation module.

[0077] In one embodiment, the host comprises a reagent tray module and a reagent arm module disposed on one side of the incubation module, and the reagent arm module transfers the reagent in the reagent tray module to the reaction cup.

[0078] In one embodiment, the reagent arm module transfers the reagent in the reagent disk module to the reaction cup through a fluidic system control, and the fluidic system includes:

[0079] A dispensing and flushing system, which is used for dispensing samples and reagents, and for flushing sample needles and reagent needles;

[0080] an acid cleaning system for acid cleaning the sample needle and the reagent needle; and

[0081] The waste discharge system is used to discharge the cleaning waste liquid.

[0082] Compared with the prior art, the advantages of the present invention are that the track conveying mechanism sends the untested sample racks in the sample rack temporary storage mechanism to the sample detection position of the host for detection. After the host completes the corresponding operation, the sample rack can be transported back to the sample rack temporary storage mechanism to wait for the detection result without waiting for the detection result at the sample detection position. Therefore, the sample conveying efficiency can be greatly improved, thereby improving the efficiency of sample delivery. BRIEF DESCRIPTION OF THE DRAWINGS

[0083] Hereinafter, the present invention will be described in more detail based on embodiments and with reference to the accompanying drawings.

[0084] Figure 1 is a schematic diagram of a three-dimensional structure of a fully automatic chemiluminescence analyzer in an embodiment of the present invention;

[0085] Figure 2 yes Figure 1 A top view of the host shown;

[0086] Figure 3 3D schematic diagram of the track sampling system of the fully automatic chemiluminescence analyzer in an embodiment of the present invention;

[0087] Figure 4 yes Figure 3 A schematic diagram of the three-dimensional structure of the track change mechanism shown;

[0088] Figure 5 yes Figure 3 The structural schematic diagram of the track change mechanism shown;

[0089] Figure 6 yes Figure 3 A schematic diagram of the three-dimensional structure of the recovery pusher shown;

[0090] Figure 7 yes Figure 3 The schematic diagram of the structure of the recycling pusher shown in FIG.

[0091] Figure 8 yes Figure 3 The three-dimensional structural schematic diagram of the sample injection pusher shown;

[0092] Fig. 9 yes Figure 3 The schematic diagram of the structure of the injection pusher

[0093] Fig.10 yes Fig. 9 A three-dimensional structural schematic diagram of the push mechanism shown;

[0094] Fig.11 yes Figure 3 The three-dimensional structural diagram of the push-back pusher shown;

[0095] Fig.12 yes Figure 3 The schematic diagram of the structure of the push back pusher shown;

[0096] Fig.13 It is a schematic diagram of the three-dimensional structure of the downward push handle and the upward push handle in an embodiment of the present invention;

[0097] Fig.14 yes Fig.13 The structural schematic diagram of the downward push handle shown;

[0098] Fig.15 yes Fig.13 The schematic diagram of the structure of the upward push handle shown in FIG.

[0099] Fig.16 yes Figure 3 A schematic diagram of the three-dimensional structure of the sample rack temporary storage mechanism shown;

[0100] Fig.17 yes Figure 2A schematic diagram of the three-dimensional structure of the detection module shown;

[0101] Fig.18 yes Figure 2 A front view of the detection module shown;

[0102] Fig.19 yes Fig.18 A cross-sectional view at AA when the excitation light path in the detection module is turned on (the section line is not shown in the figure);

[0103] Fig. 20 yes Fig.18 A cross-sectional view at AA when the excitation light path in the detection module is closed (the section line is not shown in the figure);

[0104] Fig.21 yes Fig.18 A cross-sectional view at BB when the signal light path in the detection module is turned on (the section line is not shown in the figure);

[0105] Fig. 22 yes Fig.18 A cross-sectional view at BB when the signal light path in the detection module is closed (the section line is not shown in the figure);

[0106] Fig.23 yes Figure 2 The three-dimensional structural schematic diagram of the cup sorting module is shown;

[0107] Fig.24 yes Figure 2 The three-dimensional structural schematic diagram of the upper cup module shown;

[0108] Fig.25 yes Figure 2 The three-dimensional structural schematic diagram of the sample loading arm module is shown.

[0109] In the figures, the same components are indicated by the same reference numerals. The figures are not drawn to scale.

[0110] Reference numerals:

[0111] 100-track conveying mechanism;

[0112] 110-detection track; 120-retracting track; 130-emergency track; 140-sixth sensing unit; 150-scanning unit; 160-frame; 170-roller; 180-support leg; 190-control box;

[0113] 200-sample rack temporary storage mechanism;

[0114] 210 - part to be inspected; 220 - inspected part; 230 - turnover part; 240 - sample rack; 250 - groove; 260 - walking track;

[0115] 300-track changing mechanism;

[0116] 310-fork plate; 320-tank body;

[0117] 330 - first transmission part; 340 - first belt; 350 - first slider; 360 - first slide rail;

[0118] 370 - first sensing part; 380 - second sensing part; 390 - first motor; 391 - first light shielding sheet;

[0119] 400-Recovery pusher;

[0120] 410 - second transmission part; 420 - first transverse push plate; 430 - second belt; 440 - second slider; 450 - second slide rail; 460 - third induction part; 470 - second motor; 480 - second light shielding sheet;

[0121] 500-injection pusher;

[0122] 510-third transmission part; 520-longitudinal push plate; 530-third belt; 540-third slider; 550-third slide rail; 560-fourth sensing part; 570-pushing mechanism; 571-screw; 572-rotating head; 573-fixed seat; 574-thimble; 580-third motor; 590-third light shielding sheet;

[0123] 600- push back pusher;

[0124] 610-fourth transmission part; 620-second transverse push plate; 630-fourth belt; 640-fourth slider; 650-fourth slide rail; 660-fifth sensing part; 670-fourth motor; 680-fourth light shielding sheet;

[0125] 700-downward push;

[0126] 710-fifth transmission part; 720-downward push plate; 730-motor; 840-fifth slider; 850-fifth slide rail; 760-seventh sensing part; 770-fifth light shielding plate;

[0127] 800-Move up and push the hands;

[0128] 810-sixth transmission part; 820-upward push plate; 830-sixth belt; 840-sixth slider; 850-sixth slide rail; 860-eighth induction part; 870-sixth motor; 880-sixth light shielding plate;

[0129] 900-Host;

[0130] 11- sample loading arm module; 301- sample needle; 302- connecting arm; 303- spline shaft; 304- rotating motion component; 305- up and down motion component; 306- first motor; 307- first driving wheel; 308- second synchronous belt; 309- moving block; 310- second motor; 311- second driven wheel; 312- rotating block;

[0131] 12-reagent arm module;

[0132] 13- detection module;

[0133] 131-excitation unit; 1311-exciter, 1312-excitation light path; 1313-first switch;

[0134] 132-detection unit; 1321-detector, 1322-signal light path; 1323-second switch;

[0135] 133- driving unit;

[0136] 14-reaction cup; 15-reagent module; 151-first reagent tray; 152-second reagent tray;

[0137] 16-cup upper module; 161-reaction cup clamp; 162-stepping motor; 163-synchronous pulley; 64-first synchronous belt; 165-idler wheel; 166-slide rail; 167-electromagnet; 168-first photoelectric sensor; 169-slideway; 1611-reset device; 1612-slider; 1613-slideway;

[0138] 17-cup arrangement module; 170-cup slot; 171-cup loading part; 72-cup rotating disk; 173-cup slideway; 174-first driving part; 175-first driving device; 176-longitudinal guide groove; 177-lateral guide groove; 178-friction wheel; 179-electromagnet guide part;

[0139] 18-cup transfer and discarding module; 19-incubation module; 191-first incubation tray; 192-second incubation tray; DETAILED DESCRIPTION

[0140] The present invention will be further described below in conjunction with the accompanying drawings.

[0141] like Figure 1 and 2 As shown, the present invention provides a fully automatic chemiluminescence analyzer, which includes a track conveying mechanism 100 and a sample rack temporary storage mechanism 200, wherein the sample rack temporary storage mechanism 200 is arranged at a first end of the track conveying mechanism 100, and a second end of the track conveying mechanism 100 is connected to a sample detection position ( Figure 1Corresponding to the position A shown in the figure, the track conveying mechanism 100 conveys the sample rack 240 in the sample rack temporary storage mechanism 200 to the sample detection position, and conveys the sample rack 240 back to the sample rack temporary storage mechanism 200 after the operation of the host 900 is completed.

[0142] Specifically, Figure 3 As shown, the track conveying mechanism 100 includes a detection track 110 and a retracting track 120. The first end of the detection track 110 is connected to the output end of the sample rack temporary storage mechanism 200, the first end of the retracting track 120 is connected to the input end of the sample rack temporary storage mechanism 200, the second end of the detection track 110 is connected to the second end of the retracting track 120, the second end of the retracting track 120 corresponds to the sample detection position of the host 900, and after the host 900 completes the corresponding operation on the sample rack 240 at the second end of the retracting track 120, the retracting track 120 transports the sample rack 240 back to the sample rack temporary storage mechanism 200.

[0143] In one embodiment, after the host 900 completes the operation of adding samples to the sample rack 240 at the second end of the push-back track 120 , the push-back track 120 transports the sample rack 240 back to the sample rack temporary storage mechanism 200 .

[0144] The sample rack temporary storage mechanism 200 includes a to-be-tested portion 210, an inspected portion 220 and a circulating portion 230 which are arranged in sequence. The output end of the to-be-tested portion 210 is connected to the first end of the detection track 110, the input end of the circulating portion 230 is connected to the first end of the push-back track 120, and the output end of the circulating portion 230 is connected to the input ends of the to-be-tested portion 210 and the inspected portion 220, respectively.

[0145] After the test, the sample may meet the requirements or not, and these two situations need to be sent to different locations. Therefore, in the prior art, the sample test results are waited for at the sample test location, and the sample rack is judged to be sent to where only after the test results are obtained. Therefore, there is a lot of waiting time, which makes the test efficiency low. In the present invention, by setting a turnover part 230, the sample rack 240 that has completed the test at the sample test location can be sent back to the turnover part 230 by the push-back track 120 to wait for the test results without waiting for the test results at the sample test location. Therefore, the waiting time can be greatly shortened, thereby improving the test efficiency. In addition, since the output end of the turnover part 230 is respectively connected to the input end of the to-be-tested part 210 and the tested part 220, when the sample test results in the sample rack 240 in the turnover part 230 are obtained, it can be judged where to send the sample rack 240.

[0146] Specifically, when the sample test results in the sample rack 240 in the turnover section 230 meet the requirements, the sample rack 240 is sent to the tested section 220; when the sample test results in the sample rack 240 in the turnover section 230 do not meet the requirements, the sample rack 240 is sent to the to-be-tested section 210 to wait for retesting.

[0147] The sample rack 240 on the detection track 110 is transported from the first end to the second end, and is moved to the push-back track 120 at the second end to wait for the operation of the host 900. Specifically, Figure 4 As shown, a track changing mechanism 300 is provided at the second end of the detection track 110 , and the track changing mechanism 300 transfers the sample rack 240 at the second end of the detection track 110 to the second end of the push-back track 120 .

[0148] Furthermore, the track changing mechanism 300 includes a fork plate 310 slidably disposed above the detection track 110 and the push-back track 120 , and a slot 320 for accommodating the sample rack 240 is disposed on the fork plate 310 .

[0149] The track changing mechanism 300 includes a first transmission part 330 and a first sensing part 370 which are electrically connected. The fork plate 310 is connected to the first transmission part 330 . The first sensing part 370 is used to detect whether the sample rack 240 at the second end of the detection track 110 is completely in place.

[0150] When the sample rack 240 on the detection track 110 moves to the second end of the detection track 110, the sample rack 240 enters the slot 320 on the fork plate 310. When the sample rack 240 completely enters the slot 320, the front end of the sample rack 240 touches the first sensing part 370. The first sensing part 370 sends a signal to the first transmission part 330 that the sample rack 240 is in place. Then, the first transmission part 330 starts to move, and will drive the fork plate 310 and the sample rack 240 to move to the second end of the push-back track 120. At this time, the position corresponding to the test tube at the rear end of the sample rack 240 is the sample detection position.

[0151] In one embodiment, the first transmission part 330 includes a first belt 340, a first slider 350 clamped on the first belt 340, and a first slide rail 360. The fork plate 310 is connected to the bottom of the first slider 350. When the first belt 340 is transmitted, the first slider 350 drives the fork plate 310 to move along the first slide rail 360.

[0152] like Figure 4 As shown, during the operation of the first belt 340 , the first slider 350 clamped thereon moves linearly along the first slide rail 360 , thereby driving the fork plate 310 to translate, and the sample rack 240 can be shifted.

[0153] In one embodiment, the first sensing portion 370 is a position sensor.

[0154] Furthermore, a second sensing part 380 electrically connected to the first transmission part 330 is provided at the end of the first slide rail 360, and the second sensing part 380 is used to detect whether the fork plate 310 is located directly above the detection track 110. Since the fork plate 310 needs to return to the top of the detection track 110 to wait for the next sample rack 240 to be moved after transferring the sample rack 240 to the push-back track 120, the position of the fork plate 310 must be directly above the detection track 110, otherwise the sample rack 240 on the detection track 110 will not be able to enter the slot 320 on the fork plate 310. Therefore, when the fork plate 310 is located directly above the detection track 110, the second sensing part 380 sends an electrical signal to the first transmission part 330 indicating that the fork plate 310 is fully in place, so that the first transmission part 330 starts to move.

[0155] In one embodiment, the second sensing unit 380 is a photoelectric sensor. Figure 7 As shown, a first light blocking sheet 391 is disposed on the side of the first sliding block 350 . When the first light blocking sheet 391 blocks the light beam emitted by the photoelectric sensor, it indicates that the fork plate 310 is located directly above the detection track 110 .

[0156] In addition, the first transmission part 310 includes a first motor 390 for driving the first belt 340 , and an output shaft of the first motor 390 is parallel to the length direction of the detection track 120 .

[0157] In one embodiment, the running direction of the first belt 340 is perpendicular to the running direction of the detection track 110 , which can save a certain amount of space.

[0158] like Figure 7 As shown, a recovery pusher 400 is provided at the second end of the push-back track 120, and the recovery pusher 400 moves the sample rack 240 on the push-back track 120 in a direction opposite to the running direction of the detection track 110. The function of the recovery pusher 400 is to move the sample rack 240 at the sample detection position toward the direction close to the turnover portion 230.

[0159] Since each sample rack 240 is provided with at least two test tubes ( Figure 7 FIG. 2 shows a sample rack 240 having five test tubes, so the position of one of the test tubes on the sample rack 240 corresponds to the sample detection position. When the sample in the test tube is loaded, the entire sample rack 240 needs to be pushed so that the next test tube reaches the sample detection position, and thus each test tube in the sample rack 240 is loaded with the sample in turn.

[0160] Specifically, the recovery pusher 400 moves the sample rack 240 on the push-back track 120 each time by a distance equal to the center distance between two test tubes on the sample rack 240 , thereby ensuring that the next test tube is moved exactly to the sample detection position.

[0161] The recovery push handle 400 includes a second transmission part 410 and a first transverse push plate 420 connected to the second transmission part 410. The first transverse push plate 420 is parallel to the length direction of the retreat track 120. Figure 7 As shown, the moving direction of the first transverse push plate 420 is parallel to the length direction of the push-back track 120 , so the first transverse push plate 420 pushes the sample rack 240 to move toward the direction close to the circulation portion 230 .

[0162] In one embodiment, the second transmission part 410 includes a second belt 430, a second slider 440 clamped on the second belt 430, and a second slide rail 450. The first transverse push plate 420 is connected to the top of the second slider 440. When the second belt 430 is transmitted, the second slider 440 drives the first transverse push plate 420 to move along the second slide rail 450.

[0163] Further, a third sensing part 460 is provided at both ends of the second slide rail 450, and the third sensing part 460 is used to detect whether the first transverse push plate 420 has reached the limit position. When the first transverse push plate 420 reaches the limit position on the left or the limit position on the right, the third sensing part 460 sends a signal to the second transmission part 410, so that the second transmission part 410 runs in the opposite direction.

[0164] like Figure 5 As shown, during the operation of the second belt 430 , the second slider 440 clamped thereon moves linearly along the second slide rail 450 , thereby driving the first transverse push plate 420 to translate, and the sample rack 240 can be shifted.

[0165] In one embodiment, the third sensing unit 460 is a photoelectric sensor. Figure 6 As shown, a second light blocking sheet 480 is disposed on the side of the second sliding block 440 . When the second light blocking sheet 480 blocks the light beam emitted by the photoelectric sensor, it indicates that the first transverse push plate 420 reaches the limit position.

[0166] In addition, the second transmission part 410 includes a second motor 470 for driving the second belt 430 , and an output shaft of the second motor 470 is perpendicular to the length direction of the detection track 120 .

[0167] Furthermore, the width of the first transverse pushing plate 420 is the same as the width of the sample rack 240 , or slightly larger than the width of the sample rack 240 , so as to evenly apply the force.

[0168] In one embodiment, the first transverse push plate 420 is an L-shaped plate structure.

[0169] In one embodiment, it is determined whether there is a test tube on the sample rack 240 and whether the reagent in the test tube needs to be loaded. If there is a test tube and the reagent in the test tube needs to be loaded, the loading arm module draws the sample therein for loading, thereby quickly and accurately loading the target test tube.

[0170] like Figure 8 As shown, a sample introduction handle 500 is provided at the input end of the test part 210, and the sample introduction handle 500 is used to push the sample rack 240 in the test part 210 from the input end to the output end. An opening matching the output end of the test part 210 is provided on the side wall of the test track 110, so that the sample rack 240 can enter the test track 110.

[0171] like Figure 8 and 16 As shown, the width of the detection track 110 is consistent with the width of the sample rack 240, or slightly larger than the width of the sample rack 240, so that the movement direction of the sample rack 240 in the to-be-tested part 210 is longitudinal, and the movement direction of the sample rack 240 in the detection track 110 is transverse. Therefore, when the sample rack 240 is transferred from the to-be-tested part 210 to the detection track 110, there is no need to rotate the direction, and its docking is more convenient, which can save transportation time.

[0172] Similarly, the sample racks 240 in the inspected portion 120 and the circulating portion 130 also move in the longitudinal direction.

[0173] Similarly, the width of the push-back track 120 is consistent with the width of the sample rack 240, or slightly larger than the width of the sample rack 240. Since the sample rack 240 moves from the detection track 110 to the push-back track 120 in a direction perpendicular to the running direction of the detection track 110, the moving direction of the sample rack 240 in the push-back track 120 is also horizontal, thereby reducing the space occupied by the track.

[0174] The test portion 210 can accommodate at least two sample racks 240. Figure 8 The illustrated example is a test portion 210 capable of accommodating 28 sample racks 240 .

[0175] The sample injection pusher 500 includes a third transmission part 510 and a longitudinal push plate 520 . The moving direction of the longitudinal push plate 520 is perpendicular to the moving direction of the first transverse push plate 420 .

[0176] In one embodiment, the third transmission part 510 includes a third belt 530, a third slider 540 clamped on the third belt 530, and a third slide rail 550. The longitudinal push plate 520 is connected to the top of the third slider 540. When the third belt 530 is transmitted, the third slider 540 drives the longitudinal push plate 520 to move along the third slide rail 550.

[0177] The third slide rail 550 is provided with a fourth sensing part 560 at both ends thereof, and the fourth sensing part 560 is used to detect whether the longitudinal push plate 520 has reached the limit position. When the longitudinal push plate 520 reaches the limit position on the left or the limit position on the right, the fourth sensing part 560 sends a signal to the third transmission part 510, so that the third transmission part 510 runs in the opposite direction.

[0178] like Figure 8 As shown, during the operation of the third belt 530 , the third slider 540 clamped thereon moves linearly along the third slide rail 550 , thereby driving the longitudinal push plate 520 to move horizontally, so that the sample rack 240 can be shifted.

[0179] In one embodiment, the fourth sensing unit 560 is a photoelectric sensor. Fig. 9 As shown, a third light blocking sheet 590 is disposed on the side of the third sliding block 540 . When the third light blocking sheet 590 blocks the light beam emitted by the photoelectric sensor, it indicates that the longitudinal push plate 520 reaches the limit position.

[0180] In addition, the third transmission part 510 includes a third motor 580 for driving the third belt 530 , and an output shaft of the third motor 580 is parallel to the width direction of the detection track 120 .

[0181] Furthermore, the length of the longitudinal push plate 520 is at least 1 / 3 of the length of the sample rack 240 , so as to push the sample rack 240 evenly.

[0182] In one embodiment, the longitudinal push plate 520 is in the shape of a long strip. Fig. 9 and 10As shown, a push mechanism 570 is provided at the top of the third slider 540, and the push mechanism 570 is rotatably connected to the longitudinal push plate 520. Specifically, the push mechanism 570 includes a fixed seat 573 fixedly connected to the third slider 540, a lead screw 571 provided in the fixed seat 573, one end of the lead screw 571 is connected to the rotating head 572, and the other end is provided with an ejector pin 574. When one end of the lead screw 571 contacts the ejector pin 574, since the third slider 540 is still sliding, the lead screw 571 starts to rotate under the action of the ejector pin 574, so that the rotating head 572 drives the longitudinal push plate 520 to rotate upward (in the height direction of the sample rack 240), and the longitudinal push plate 520 will not hinder the input end of the to-be-tested part 210, so that the sample rack 240 from the circulating part 230 can enter from the input end of the to-be-tested part 210.

[0183] And, if Figure 8 As shown, a spring 575 is further provided at the connection between the rotating head 572 and the longitudinal push plate 520 . When the longitudinal push plate 520 cannot be rotated by the ejector pin 574 , the longitudinal push plate 520 can be rotated by the spring 575 .

[0184] like Fig.11 As shown, a push-back handle 600 is provided at the front end of the sample rack temporary storage mechanism 200 , and the push-back handle 600 is used to push the sample rack 240 at the output end of the turnover area to the input end of the to-be-tested part 210 or the input end of the tested part 220 .

[0185] In one embodiment, the push-back handle 600 includes a fourth transmission part 610 and a second transverse push plate 620, and the moving direction of the second transverse push plate 620 is parallel to the moving direction of the second transverse push plate 620. The fourth transmission part 610 includes a fourth belt 630, a fourth slider 640 clamped on the fourth belt 630, and a fourth slide rail 650, and the second transverse push plate 620 is arranged at the upper end of the fourth slider 640.

[0186] Further, both ends of the fourth transmission part 610 are provided with a fifth sensing part 660, and the fifth sensing part 660 is used to detect whether the second transverse push plate 620 has reached the limit position. When the second transverse push plate 620 reaches the limit position on the left or the limit position on the right, the fifth sensing part 660 sends a signal to the fourth transmission part 610, so that the fourth transmission part 610 runs in the opposite direction.

[0187] In one embodiment, the fifth sensing unit 660 is a photoelectric sensor. Fig.12 As shown, a fourth light blocking sheet 680 is disposed on the side of the fourth sliding block 640. When the fourth light blocking sheet 680 blocks the light beam emitted by the photoelectric sensor, it indicates that the second transverse push plate 620 reaches the limit position.

[0188] In addition, the fourth transmission part 610 includes a fourth motor 670 for driving the fourth belt 630 , and an output shaft of the fourth motor 670 is parallel to the length direction of the detection track 120 .

[0189] Furthermore, the length of the second transverse pushing plate 620 is greater than the width of the sample rack 240 so as to push the sample rack 240 evenly.

[0190] In one embodiment, the second transverse push plate 620 is in the shape of an elongated strip.

[0191] like Fig.13 As shown, a downward push handle 700 is provided at the input end of the inspected part 220, and the downward push handle 700 is used to push the sample rack 240 in the inspected part 220 downward from the input end. The downward push handle 700 includes a fifth transmission part 710 and a downward push plate 720, and the moving direction of the downward push plate 620 is parallel and the same as the moving direction of the longitudinal push plate 520.

[0192] In one embodiment, Fig.14 As shown, the fifth transmission part 710 includes the fifth transmission part 610 , and the fifth transmission part 610 includes a fifth motor 730 , a fifth slider 740 connected to the fifth motor, and a fifth slide rail 750 , and the downward push plate 720 is arranged at the upper end of the fifth slider 740 .

[0193] The fifth motor 730 enables the fifth slider 740 to drive the downward push plate 720 to perform reciprocating motion. Seventh sensing parts 760 are respectively provided at both ends of the fifth slider 740. The seventh sensing parts 760 are used to detect the position of the downward push plate 720. The downward push plate 720 pushes the sample rack 240 at the input end of the inspected part 220 downward. After pushing each sample rack 240, the downward push plate 720 returns to the initial position to wait for the next sample rack 240 to be pushed.

[0194] In one embodiment, the seventh sensing part 760 is a photoelectric sensor. A fifth light blocking sheet 770 is disposed on the side of the fifth slider 640. When the fifth light blocking sheet 770 blocks the light beam emitted by the photoelectric sensor, it indicates that the downward push plate 720 reaches the limit position.

[0195] In addition, the output shaft of the fifth motor 730 is parallel to the length direction of the detection rail 120 .

[0196] Furthermore, the length of the downward push plate 720 is at least greater than 1 / 3 of the length of the sample rack 240 , so as to evenly push the sample rack 240 .

[0197] In one embodiment, the downward push plate 720 is in the shape of a flat plate.

[0198] The downward push plate 720 is flush with the end surface of the input end of the inspected portion 220 , so the downward push plate 720 will not cause any obstruction to the input end of the inspected portion 220 .

[0199] like Fig.13 As shown, the input end of the inspection part 220 of the circulation part 230 is provided with an upward pusher 800, and the upward pusher 800 is used to push the sample rack 240 in the circulation part 230 from the input end to the output end. The upward pusher 800 includes a sixth transmission part 810 and an upward push plate 820, and the moving direction of the upward push plate 820 is parallel to and opposite to the moving direction of the longitudinal push plate 520.

[0200] The sixth transmission part 810 includes a sixth belt 830 , a sixth slider 840 clamped on the sixth belt 830 , and a sixth slide rail 850 . The upward push plate is disposed at the upper end of the sixth slider 840 .

[0201] Furthermore, the eighth sensing part 860 is provided at both ends of the sixth transmission part 810, and the eighth sensing part 860 is used to detect whether the upward push plate reaches the limit position. When the upward push plate reaches the limit position on the left or the limit position on the right, the eighth sensing part 860 sends a signal to the sixth transmission part 810, so that the sixth transmission part 810 runs in the opposite direction.

[0202] In one embodiment, the eighth sensing unit 860 is a photoelectric sensor. Fig.15 As shown, a sixth light blocking sheet 880 is disposed on the side of the sixth sliding block 840. When the sixth light blocking sheet 880 blocks the light beam emitted by the photoelectric sensor, it indicates that the upward push plate 820 reaches the limit position.

[0203] In addition, the sixth transmission part 810 includes a sixth motor 870 for driving the sixth belt 830 , and an output shaft of the sixth motor 870 is parallel to the length direction of the detection track 120 .

[0204] Furthermore, the width of the upward pushing plate 820 is at least greater than 1 / 3 of the length of the sample rack 240 so as to push the sample rack 240 evenly.

[0205] In one embodiment, the upward push plate 820 is a U-shaped plate, and the width of the upward push plate 820 described herein is the opening width of the U-shaped plate. Figure 6 As shown, the to-be-tested portion 210, the tested portion 220 and the circulating portion 230 are all provided with a running track 260, and the bottom end of the sample rack 240 is provided with a groove 250, which matches with the running track 260. Thus, when the sample rack 240 is pushed to move in the to-be-tested portion 210, the tested portion 220 and the circulating portion 230, its running track can be kept as a straight line.

[0206] In one embodiment, the detection track 110 is a conveyor belt, and the push-back track 120 is a slide groove arranged parallel to the conveyor belt.

[0207] In addition, the present invention also provides an emergency channel. Specifically, the track conveying mechanism 100 includes an emergency track 130, the first end of the emergency track 130 is an input end or an output end, and the second end of the emergency track 130 corresponds to the emergency sample introduction position of the host 900. The emergency track 130 has a higher priority than the detection channel 110, that is, the sample rack 240 on the emergency channel 130 can be detected in priority to the sample rack 240 on the detection channel 110.

[0208] Specifically, the emergency track 130 is a conveyor belt arranged parallel to the detection track 110 .

[0209] A sixth sensing portion 140 is disposed at the second end of the emergency track 130 . The sixth sensing portion 140 is used to detect whether the sample rack 240 on the emergency track 130 is completely in place.

[0210] When an emergency sample needs to be tested, the sample rack 240 is placed through the first end of the emergency channel 130, and the sample rack 240 is transported to the second end of the emergency channel 130. The second end of the emergency channel 130 corresponds to the emergency sample detection position of the host 900. At this time, the detection channel 110 stops. When the sixth sensing unit 14 detects that the sample rack 240 on the emergency track 130 is fully in place, it sends a signal to the host 900 to make the host 900 add samples from the emergency sample detection position. After the addition of samples is completed, the emergency track 130 runs in the reverse direction, so that the sample rack 240 is transported from the second end to the first end and taken out from the first end.

[0211] Likewise, the width of the emergency track 130 is consistent with the width of the sample rack 240 , or slightly larger than the width of the sample rack 240 , and the moving direction of the sample rack 240 in the emergency track 130 is also horizontal, thereby reducing the space occupied by the track.

[0212] In addition, a scanning unit 150 is disposed on both the detection track 110 and the emergency track 130. A barcode is disposed on the sample rack 240. When the sample rack 240 passes through the scanning unit 150, the scanning unit 150 can obtain the properties of the samples in the sample rack 240.

[0213] Among them, the barcode format should at least support: Code 128, Code 39, Codabar, 2 / 5 Interleaved.

[0214] Furthermore, since the specifications of the test tubes are different specifications with an outer diameter of 12-16 mm and a height of 75-100 mm, the scanning unit 150 can also support the identification of the types of the test tubes on the sample rack.

[0215] In one embodiment, the sample temporary storage mechanism 200 is disposed on the rack 160. Figure 1As shown, the bottom end of the rack 160 is provided with rollers 170 for walking and support legs 180 for supporting the rack 160. When the rack 160 needs to be pushed, the rollers 170 are put down and the support legs 180 are folded up to push the rack 160; when the rack 160 needs to be stopped somewhere, the rollers 170 are folded up and the support legs 180 are put down to fix the rack 160 on the ground.

[0216] In addition, a control box 190 is disposed on the frame 160 , which is electrically connected to each sensing part and each transmission part in the above embodiment.

[0217] It should be noted that the horizontal direction described in the present invention is the running direction of the detection track 110, that is, Figure 1 The X-axis direction is shown, and the vertical direction is Figure 1 The Y-axis direction is shown.

[0218] like Figure 2 As shown, the main unit 1 includes a loading arm module 11, a reagent arm module 12 and a detection module 13 arranged above the incubation module 19, wherein the loading arm module 11 transfers the sample at the sample detection position to the reaction cup 14, the reagent arm module 12 transfers the reagent in the reagent module 15 to the reaction cup 14 and mixes it with the sample in the reaction cup 14, and then the reaction cup 14 is incubated in the incubation module 19. After the incubation is completed, the detection module 13 performs optical excitation on the sample in the reaction cup and detects the luminescent signal generated after the excitation.

[0219] The incubation module 19 includes a first incubation tray 191 and a first incubation tray 192, and the reagent module 15 includes a first reagent tray 151 and a second reagent tray 152. The incubation trays are driven to rotate by a motor, and a cup transfer and cup abandonment module 18 is provided between the first incubation tray 191 and the first incubation tray 192. The cup transfer and cup abandonment module 18 includes a cup push track and a cup abandonment track, and the track between the cup push track and the cup abandonment track is changed by linear electric motion. When the incubation time of the reaction cup on the first incubation tray 191 ends, the reaction cup 14 rotates to the reaction cup removal position of the first incubation tray 191, and the reaction cup of the first incubation tray 192 also rotates to the reaction cup removal position. At this time, the cup transfer and cup abandonment module 18 is started, and the track is moved to the cup abandonment track, and the reaction cup of the first incubation tray 192 is discarded; then the cup transfer and cup abandonment module 18 switches to the cup transfer track, and the detection reaction cup of the first incubation tray 191 is pushed to the first incubation tray 192.

[0220] In one embodiment, Fig.25 As shown, the loading arm module 11 includes a bracket and an arm assembly. The arm assembly is arranged on the upper part of the bracket. The bracket is also provided with an up and down motion assembly 305 and a rotation motion assembly 304 respectively connected to the arm assembly. The up and down motion assembly 305 enables the arm assembly to move up and down relative to the bracket, and the rotation motion assembly 304 enables the arm assembly to rotate relative to the bracket.

[0221] The arm assembly includes a connecting arm 302, one end of which is vertically fixedly connected to a sample needle 301, and the other end of which is vertically fixedly connected to a spline shaft 303. The spline shaft 303 can transmit motion in a linear direction and torque in a circumferential direction. The sample needle 301 is fixedly connected to the spline shaft 303 through the connecting arm 302, so that the sample needle 301 can move with the up and down motion or rotational motion of the spline shaft 303.

[0222] In one embodiment, the up and down motion component 305 includes a first motor 306, the first motor 306 is connected to the first driving wheel 307, the first driving wheel 307 is connected to the first driven wheel through the second synchronous belt 308, a moving block 309 is fixed on the second synchronous belt 308, and the lower end of the spline shaft 303 passes through the moving block 309. When the first motor 306 is started, it drives the first driving wheel 307 to rotate, thereby driving the second synchronous belt 308 to rotate, and the moving block 309 moves up and down with the rotation of the second synchronous belt 309. The spline shaft 303 moves up and down with the moving block 309, thereby driving the sample needle 302 fixedly connected to the spline shaft 303 through the connecting arm 302 to move up and down.

[0223] Preferably, retaining rings are provided at the upper and lower ends of the moving block 309 to prevent the spline shaft 303 from moving up and down relative to the moving block.

[0224] In one embodiment, the rotary motion assembly 304 includes a second motor 310, the second motor 310 is connected to the second driving wheel, the second driving wheel is connected to the second driven wheel 311 through the third synchronous belt, the upper part of the second driven wheel 311 is provided with a rotating block, and the second driven wheel and the rotating block 312 are both sleeved on the outside of the spline shaft 303. When the second motor 310 is started to drive the third synchronous belt to rotate, the third synchronous belt will drive the second driven wheel 311 to rotate. The rotation of the second driven wheel 311 drives the spline shaft 303 to rotate. Since the spline shaft 303 can rotate relatively inside the rotating block 312, the spline shaft 303 rotates with the rotation of the second driven wheel 311, thereby driving the rotation of the sample needle 301 fixedly connected to the spline shaft 303 through the connecting arm 302.

[0225] Preferably, a flat key is provided between the second driven wheel 311 and the spline shaft 302 to prevent the spline shaft 302 and the second driven wheel 311 from rotating relative to each other.

[0226] The sample needle 301 of the sample loading arm module 11 can move with the up-and-down movement or rotational movement of the spline shaft 303. This structure not only allows the sample needle 301 to load samples or reagents at different positions, but also because only the spline shaft rotates, it is small in size, simple in structure, easy to assemble and maintain, and low in cost; and because the combination of rotation and up-and-down movement is adopted, the movement trajectory of the sample needle 301 is determined, which not only has a fast speed but also reduces the probability of error and has high accuracy.

[0227] The cup arrangement module 17 is located behind the sample loading arm module 11. Fig.23 As shown, the cup arrangement module 17 includes a cup loading portion 171 for holding reaction cups and a cup arranging device located at the bottom of the cup loading portion 171. An opening is provided on one side of the cup loading portion 171, and the opening extends from the top of one side of the cup loading portion 171 to the bottom. The opening transitions from the top to the middle of one side of the cup loading portion 171 in an arc shape, so that the volume from the top to the middle of the cup loading portion 171 gradually increases. The inner wall of the cup loading portion 171 is smoothly arranged, and under the action of the smooth inner wall of the cup loading portion 171, the reaction cup 14 can quickly enter the cup arranging device.

[0228] The cup arrangement device includes a tray fastened to the bottom of the cup loading part 171 and a reaction cup rotating disk 172 disposed in the tray. A cup groove 170 matching with the reaction cup 14 is disposed at the circumferential edge of the top of the reaction cup rotating disk 172 (the position on the reaction cup rotating disk 172 that contacts the reaction cup 14). A first driving part 174 for driving the reaction cup 14 to be discharged from the cup groove 170 is disposed on one side of the reaction cup rotating disk 172. The reaction cup rotating disk 172 is driven to rotate by the first driving device 175. Under the action of the rotation of the reaction cup rotating disk 172, the reaction cups 14 at the bottom of the cup loading part 171 can be placed in the cup groove 170 in sequence, and then under the action of the first driving part 174, the reaction cups 14 are uniformly discharged from the cup groove 170.

[0229] A reaction cup slide 173 connected to the cup groove 170 is arranged inside the reaction cup slide base, a longitudinal guide groove 176 is arranged on the reaction cup slide 173, a transverse guide groove 177 connected to the longitudinal guide groove 176 is arranged transversely at the bottom of the longitudinal guide groove 176, and a second driving device for driving the reaction cup 14 in the transverse guide groove 177 to slide to the end in sequence along the transverse guide groove 177 is arranged on one side of the transverse guide groove 177.

[0230] In one embodiment, the second driving device includes a driving motor and a friction wheel 178 that is fastened to the output shaft of the driving motor and controls the movement of the reaction cup 14. The driving motor drives the friction wheel 178 to rotate. During the rotation of the friction wheel 178, the peripheral surface of the friction wheel 178 contacts the flange of the reaction cup 14, and the action force between the friction wheel 178 and the reaction cup 14 drives the reaction cup 14 to move in an upright posture along the transverse guide groove 175 toward its end.

[0231] Preferably, an electromagnet guide portion 179 for controlling the reaction cups to be neatly discharged from the transverse guide groove 175 is provided at the end of the transverse guide groove 175 , and a contact sensor is provided at the beginning of the electromagnet guide portion 179 .

[0232] The reaction cup in the transverse guide groove 175 stops moving after hitting the contact sensor of the electromagnet guide part 179 .

[0233] The cup arrangement module 17 can arrange the disordered cuvettes into an orderly arrangement, and push them to the first incubation disk 191 in an orderly manner through the cup loading module 16, thereby improving the detection efficiency of the sample. First, the cuvette 14 is placed in the cup loading part 171 through the opening, and the first driving device drives the cuvette rotating disk 172 to rotate counterclockwise, and the cuvettes 14 in the cup loading part 171 enter the cup groove 170 in sequence. The cuvette rotating disk 172 rotates counterclockwise, driving the dial wheel to rotate counterclockwise periodically, and the cuvettes 14 in the cup groove 170 can be transported to the cuvette slideway 173 in sequence, lying flat, and uniformly, and then the cuvettes 14 enter the longitudinal guide groove 176 and the transverse guide groove 177 in sequence. When the cuvette rotating disk 172 has a cup jam failure, the first motor is idle under the action of the friction clutch in the first driving device, and the cuvette 14 stuck on the cuvette rotating disk 172 can be easily removed. When the position of the reaction cup 14 in the longitudinal guide groove 176 reaches the position of the full cup sensor, the reaction cup rotating disk 172 stops rotating. The second motor drives the friction wheel 178 to move, and ensures that the friction wheel 178 contacts the reaction cup 14, and controls the reaction cup 14 to move from the beginning of the transverse guide groove 177 to the end in a uniform and upright posture. After the reaction cup 14 at the end of the transverse guide groove 177 hits the contact sensor, the reaction cup 14 stops moving, thereby achieving the purpose of arranging the messy reaction cups 14. The upper cup module 16 is located between the cup organizing module 17 and the incubation module 19, and includes a slide rail 166, a cup clamping device, a transmission device, a slideway and a reset device, wherein the cup clamping device is slidably connected to the slide rail 166, the transmission device is located above the slide rail 166, and is used to control the cup clamping device to move along the slide rail 166, the slideway 169 is located below the cup clamping device, the reaction cup 14 is located in the slideway 169, and the cup clamping device can control the reaction cup 14 to move in the slideway 169; the reset device is used to reset the cup clamping device, and preferably, the reset device is fixed above one end of the slide rail 166.

[0234] The cup clamping device includes: a slider 1612, a reaction cup clamping claw 161, an electromagnet 167 and a first photocurrent sensor 168. The slider 1612 is slidably connected with the slide rail 166, a reaction cup clamping claw 161 is provided on one side of the slider 1612, the reaction cup clamping claw 161 slides vertically relative to the slider 1612, and a slide groove 1613 for a limit screw to pass through is provided on the reaction cup clamping claw 161, and the limit screw connects the reaction cup clamping claw 161 to the slider 1612 through the slide groove 1613. An electromagnet 167 is provided above the cuvette gripper 161 for controlling the vertical sliding of the cuvette gripper 161 relative to the slider 1612, wherein the electromagnet 167 is fixedly connected to the slider 1612. When the electromagnet 167 is powered on, the cuvette gripper 161 leaves the electromagnet 167 and moves downward along the slide 1613. When the electromagnet 167 is not powered on, the cuvette gripper 161 is adsorbed on the lower end of the electromagnet 167. A first photocurrent sensor 168 is provided on one side of the cuvette gripper 161 for detecting the position of the cuvette gripper 161.

[0235] like Fig.24 As shown, the bottom of the reaction cup 14 is hemispherical, the cup body is cylindrical, a cylindrical protrusion is arranged in the center of the bottom of the cup, and a cup edge protruding outward is arranged around the cup mouth, and the diameter of the cup edge is larger than the diameter of the reaction cup 14. A limiting groove is arranged at the bottom of the reaction cup gripper 161, and the limiting groove is used to clamp the reaction cup 14, wherein the length of the limiting groove is the same as the diameter of the cup edge. When the reaction cup 14 is moved, the cup edge of the reaction cup 14 is clamped in the limiting groove, and the reaction cup 14 moves with the movement of the reaction cup gripper 161. Since the reaction cup gripper 161 moves down to the edge of the reaction cup when the electromagnet is energized, the reaction cup 14 only moves horizontally in the slideway 169 with the reaction cup gripper 161 instead of vertically, so the reaction cup will not fall off, and the gripper has a simple structure, which is easy to assemble and process.

[0236] Preferably, the cup clamping device and the slide rail 166 are arranged perpendicular to each other. Above the slide rail 166, an idler wheel 165 and a synchronous pulley 163 are respectively arranged at both ends of the slide rail 166. The idler wheel 165 and the synchronous pulley 163 are connected together by a synchronous belt 164. The cup clamping device is vertically connected to the first synchronous belt 164, and the first synchronous belt 164 is driven to rotate by a stepper motor 162. When the first synchronous belt 164 rotates, it drives the cup clamping device to move along the slide rail 166 between the cup sorting module 17 and the incubation tray module.

[0237] Preferably, the slide 169 is located below the reaction cup clamp 161 and is arranged parallel to the slide rail 166. The reaction cup clamp 161 is sensed by the electromagnet 167, driving the reaction cup 14 to reach the incubation tray module through the slide 169. The reaction cup 14 sorted by the cup sorting module 17 is located at one end of the slide rail 166. At this time, the electromagnet 167 is started, and the photoelectric sensor 168 senses that the electromagnet 167 is started, and drives the clamping cup gripper 161 to move downward. The bottom opening of the clamping cup gripper 161 clamps the edge of the reaction cup 14. At the same time, the stepping motor 162 drives the first synchronous belt 164 to rotate, driving the reaction cup moving device to move along the slide rail 166 toward the direction of the first incubation tray 5. The reaction cup 14 passes through the slide 169 and reaches the first incubation tray 5.

[0238] Preferably, the reset device 1611 is a second photoelectric induction sensor, including an N-shaped groove that enables the cup clamping device to pass through. After the electromagnet 167 is powered off, the reaction cup claw 161 moves up until the first photocurrent sensor 14 detects that the reaction cup claw 161 passes through the U-shaped groove of the first photocurrent sensor. The reaction cup claw 161 is adsorbed on the electromagnet 167 and leaves the reaction cup 14. At this time, the stepper motor 162 moves, driving the synchronous pulley 163 to rotate in the opposite direction to that when the cup is sent. The first synchronous belt 164 drives the cup clamping device to move in the opposite direction to that when the cup is sent until the cup clamping device returns to the N-shaped groove of the second photocurrent sensor reset device, that is, returns to the other end of the incubation plate, completing the process of sending the cup to return.

[0239] Through the cup loading module 16, the reaction cup 14 can be directly moved in a plane between the cup sorting module 17, the slide 169, and the first incubation tray 5, thereby avoiding the problems of high error rate, cup drop, and low work efficiency caused by the three-dimensional robotic arm gripper grasping the reaction cup 14. In addition, the motor adopts a stepping motor to control the belt transmission device to make the pulley run more smoothly.

[0240] The fully automatic chemiluminescence analyzer of the present invention completes the detection through the following process:

[0241] The detection track 31 pushes the sample to be detected to the sample absorption position; the cup arrangement module 17 organizes the disordered reaction cups 14 in order and arranges them neatly, and pushes the reaction cups 14 to the cup entry position of the first incubation tray 191 through the cup loading module 16; then, the first incubation tray 191 rotates to transfer the reaction cups 14 from the cup entry position to the sample loading position; then, the sample loading arm module 11 controls the rotation through the flow path system, absorbs the sample from the test tube that reaches the sample absorption position in the detection track 31, and then rotates to the sample loading position of the first incubation tray 191 to add the sample to the reaction cup 14 at the sample loading position; if an emergency sample is encountered, the sample loading arm module 11 will first absorb the emergency sample, and then continue to absorb the sample in the previous detection track 31 after the emergency sample sampling is completed; then, the sample loading arm module 11 absorbs the diluent to dilute the sample, and then the first incubation tray 191 continues to rotate to load the reaction cup 14 on the sample loading position. From the sample loading position to the reagent position, the first reagent disk 151 rotates at the same time, and the reagent on the first reagent disk 151 is transferred to the first reagent suction position; the first reagent arm is controlled by the flow system to absorb a certain amount of the first reagent from the reagent suction position of the first reagent disk 151, rotate to the reagent position of the first incubation disk 191, and add the first reagent to the reaction cup 14;

[0242] Subsequently, the first incubation tray 191 continues to rotate, transferring the reaction cup 14 from the first reagent position to the second reagent position, and at the same time, the first reagent tray 151 rotates to transfer the reagent to the second reagent aspiration position; the second reagent arm is controlled by the flow system to absorb a certain amount of the second reagent from the reagent aspiration position of the first reagent tray 152, rotate to the second reagent position of the first incubation tray 191, add the reagent to the reaction cup 14, and the first incubation tray 191 will transfer the reaction cup 14 containing the mixed liquid to the mixing position; then, the mixing mechanism will mix the sample in the reaction cup 14; thereafter, the reaction cup 14 will be rotated and incubated in the first incubation tray 191 according to a certain period. After the incubation time is up, the reaction cup 14 just rotates to the reaction cup removal position of the first incubation tray 191; at the same time, the first incubation tray 192 rotates to the reaction cup 14 removal position, the cup transfer and discarding module 18 is started, the track moves to the cup discarding track, and the reaction cup 14 on the second incubation tray 13 is discarded; then the cup transfer and discarding module 18 switches to the cup transfer track, and the reaction cup 14 that needs to be tested on the first incubation tray 191 is pushed to the first incubation tray 192. The reaction cup 14 is transferred to the reagent addition position with the first incubation tray 192; at the same time, the second reagent tray 152 rotates, and the reagent is transferred to the third reagent absorption position of the second reagent tray 152; the third reagent arm rotates, and the third reagent is sucked out of the reagent bottle through the flow system control, and then transferred to the reagent addition position of the second incubation tray, and the reagent is spit into the reaction cup 14. After that, the reaction cup 14 rotates with the first incubation tray 192. After the incubation time is up, the reaction cup 14 is transferred to the optical path detection device 18. The optical path detection system 18 performs optical detection on the sample in the reaction cup 14, excites the sample with the excitation light emitted by the excitation unit to generate a luminescent signal, performs multiple collections and readings, and converts the above chemiluminescent signal into a digital signal for corresponding processing (the process of detecting the chemiluminescent signal by the detection component includes collecting the chemiluminescent signal and reading the signal and performing corresponding processing on the chemiluminescent signal), and then transmits it to the control system so that the control system can detect and analyze the information it receives.

[0243] Then the reaction cup 14 rotates with the first incubation tray 192 and moves to the reagent reaction cup entry and exit position of the first incubation tray 192.

[0244] The cuvette 14 after detection is pushed out and discarded. Thus, the whole sample detection process is completed.

[0245] The entire operation is automated, which can effectively avoid the uncertainties of individual differences, manual errors, operating specifications, etc. in manual operations, and improve the accuracy of chemiluminescent immunoassay.

[0246] Furthermore, the first incubation disk 192 moves the same substance to be tested to the testing position multiple times by rotating, so that the testing module 13 performs multiple tests on the substance to be tested, thereby determining whether there is a HOOK risk in the immunoassay.

[0247] In some embodiments, the above detection position refers to the position where the detection mechanism is located (ie, the position where the excitation light is generated). Of course, the above detection position can also be the position where the substance to be detected is located on the first incubation tray 192.

[0248] like Fig.17 and 18 As shown, the detection module 13 includes an excitation unit 131 for emitting excitation light and exciting the object to be detected and a detection unit 132 for receiving and detecting the luminescent signal generated by the object to be detected. The excitation unit 131 and the detection unit 132 do not work at the same time.

[0249] In one embodiment, the excitation unit 131 includes an exciter 1311 , and the exciter 1311 can emit red excitation light of 600-700 nm.

[0250] Among them, the exciter 1311 is arranged above the substance to be tested, and in the excitation part 131, except for the exciter 1311 which does not move periodically with the first incubation tray 192, the other components of the excitation part 131 can move periodically with the first incubation tray 192, and the present invention is not limited to this.

[0251] In one embodiment, the detection unit 132 includes a detector 1321 , wherein the detector 1321 is a single photon counter, a photomultiplier tube, a silicon photocell, or a photometric integrating sphere.

[0252] The wavelength of the light emitting signal that can be detected by the detection unit 132 is 520 to 620 nm.

[0253] Similarly, in the detection part 132, except for the detector 1321 which does not perform periodic motion with the first incubation tray 192, the remaining components of the detection part 132 can perform periodic motion with the first incubation tray 192, and the present invention is not limited to this.

[0254] Furthermore, if Fig.17 As shown, the excitation unit 131 includes an excitation light path 1312 , and the detection unit 132 includes a signal light path 1322 . The excitation light path 1312 and the signal light path 1322 are neither turned on nor turned off at the same time.

[0255] The excitation light path 1312 and the signal light path 1322 are both disposed on the housing, and the axis of the excitation light path 1312 is perpendicular to the axis of the signal light path 1322. Fig.17As shown, the axis L1 of the excitation light path 1312 is along the Z-axis direction, and the axis L2 of the signal light path 1322 is along the X-axis direction.

[0256] The excitation light path 1312 is provided with a first switch 1313 for controlling the excitation light path 1312 to be turned on or off, and the signal light path 1322 is provided with a second switch 1323 for controlling the signal light path 1322 to be turned on or off, and the first switch 1313 and the second switch 1323 are reversely linked. Thus, the excitation light path 1312 and the signal light path 1322 are driven to be turned on and off simultaneously, specifically as follows: when the excitation light path 1312 is turned on, the signal light path 1322 is turned off; when the excitation light path 1312 is turned off, the signal light path 1322 is turned on.

[0257] Specifically, when the excitation light is needed to excite the object to be tested, the driving unit 133 rotates, and the driving unit 133 drives the first switch 1313 to rotate, and the excitation light path 1312 is turned on (such as Fig.19 As shown), the driving unit 133 drives the second switch 1323 to rotate, and the signal light path 1322 is in a closed state (as shown Fig. 22 shown).

[0258] Similarly, when receiving and detecting the luminous signal generated by the object to be tested, the driving unit 133 rotates again, and the driving unit 133 drives the first switch 1313 to rotate, and the first switch 1313 blocks the excitation light path 1312 (such as Fig. 20 As shown), the driving unit 133 drives the second switch 1323 to rotate, and the signal light path 1322 is in an open state (as shown Fig.21 As shown in FIG. 1 , the driving unit 133 controls the opening and closing of the excitation light path 1312 and the signal light path 1322 at the same time.

[0259] The first switch 1313 and the second switch 1323 are connected to two ends of the driving unit 133 respectively, and the driving unit 133 makes the first switch 1313 and the second switch 1323 work in opposite directions.

[0260] The driving part 133 is a rotating electromagnet or a motor. Output shafts are respectively provided at both ends of the driving part 133 , one end of which is connected to the first switch 1313 , and the other end of which is connected to the second switch 1323 .

[0261] Although the present invention has been described with reference to preferred embodiments, various modifications may be made thereto and parts thereof may be replaced by equivalents without departing from the scope of the present invention. In particular, the various technical features mentioned in the various embodiments may be combined in any manner as long as there are no structural conflicts. The present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A fully automatic chemiluminescence analyzer, characterized in that: include: A host, which is used to obtain a sample located at a sample detection position and detect the sample; A track conveying mechanism is used to convey the sample rack carrying the sample. A sample rack temporary storage mechanism, located at one side of the mainframe and used for storing the sample rack; Wherein, the first end of the track conveying mechanism is connected to the sample rack temporary storage mechanism, and the second end of the track conveying mechanism corresponds to the sample detection position of the host. The track conveying mechanism transports the sample rack in the sample rack temporary storage mechanism to the sample detection position, and transports the sample rack back to the sample rack temporary storage mechanism after the host completes the corresponding operation; The track conveying mechanism includes a detection track and a push-back track, wherein the first end of the detection track is connected to the output end of the sample rack temporary storage mechanism, the first end of the push-back track is connected to the input end of the sample rack temporary storage mechanism, the second end of the detection track is connected to the second end of the push-back track, the second end of the push-back track corresponds to the sample detection position of the host, and after the host completes the operation on the sample rack at the second end of the push-back track, the push-back track transports the sample rack back to the sample rack temporary storage mechanism; A track changing mechanism, the track changing mechanism is arranged at the second end of the detection track, and the track changing mechanism transfers the sample rack at the second end of the detection track to the second end of the push-back track; A recovery pusher is arranged at the second end of the push-back track, and the recovery pusher moves the sample rack on the push-back track in a direction opposite to the running direction of the detection track.

2. The fully automatic chemiluminescence analyzer according to claim 1, characterized in that: The sample rack temporary storage mechanism includes a to-be-tested portion, an inspected portion and a turnover portion which are arranged in sequence, wherein the output end of the to-be-tested portion is connected to the first end of the detection track, the input end of the turnover portion is connected to the first end of the push-back track, and the output end of the turnover portion is respectively connected to the input ends of the to-be-tested portion and the inspected portion.

3. The fully automatic chemiluminescence analyzer according to claim 1 or 2, characterized in that: The sample introduction pusher is provided at the input end of the to-be-tested part and is used to push the sample rack in the to-be-tested part from the input end to the output end.

4. The fully automatic chemiluminescence analyzer according to claim 1 or 2, characterized in that: It comprises a push-back pusher, which is arranged at the end of the sample rack temporary storage mechanism and is used to push the sample rack at the output end of the turnover area to the input end of the to-be-tested part or the input end of the tested part.

5. The fully automatic chemiluminescence analyzer according to claim 1 or 2, characterized in that: It comprises a downward pusher, which is arranged at the input end of the tested part and is used to push the sample rack in the tested part downward from the input end.

6. The fully automatic chemiluminescence analyzer according to claim 2, characterized in that: It comprises an upward pusher, which is arranged at the input end of the turnover part and is used to push the sample rack in the turnover part from the input end to the output end.

7. The fully automatic chemiluminescence analyzer according to claim 2, characterized in that: The to-be-tested portion, the tested portion and the turnover portion are all provided with running tracks, and the bottom end of the sample rack is provided with a groove, and the groove matches the running track.

8. The fully automatic chemiluminescence analyzer according to claim 1 or 2, characterized in that: The detection track is a conveyor belt, and the push-back track is a slide groove arranged parallel to the conveyor belt.

9. The fully automatic chemiluminescence analyzer according to claim 8, characterized in that: The track conveying mechanism comprises an emergency track, a first end of the emergency track is an input end or an output end, and a second end of the emergency track corresponds to an emergency sample introduction position of a host.

10. The fully automatic chemiluminescence analyzer according to claim 9, characterized in that: The emergency track is a conveyor belt arranged parallel to the detection track.

11. The fully automatic chemiluminescence analyzer according to claim 10, characterized in that: A sixth sensing portion is disposed at the second end of the emergency track, and the sixth sensing portion is used to detect whether the sample rack on the emergency track is completely in place.

12. The fully automatic chemiluminescence analyzer according to claim 11, characterized in that: The detection track and the emergency track are both provided with scanning parts.

13. The fully automatic chemiluminescence analyzer according to claim 1 or 2, characterized in that: The host comprises an incubation module and a sample loading arm module arranged at a sample detection position, and the sample loading arm module transfers the sample at the sample detection position to a reaction cup in the incubation module for incubation.

14. The fully automatic chemiluminescence analyzer according to claim 13, characterized in that: The loading arm module comprises a support and an arm assembly, and the arm assembly is arranged on the upper part of the support.

15. The fully automatic chemiluminescence analyzer according to claim 13, characterized in that: The host comprises a detection module arranged above the incubation module. After the incubation is completed, the detection module performs optical excitation on the sample in the reaction cup and detects the luminescent signal generated after the excitation.

16. The fully automatic chemiluminescence analyzer according to claim 15, characterized in that: The detection module comprises an excitation part for emitting excitation light and exciting the object to be detected and a detection part for receiving and detecting a luminescent signal generated by the object to be detected.

17. The fully automatic chemiluminescence analyzer according to claim 16, characterized in that: The excitation section and the detection section do not operate simultaneously.

18. The fully automatic chemiluminescence analyzer according to claim 13, characterized in that: The host comprises a cup-arranging module arranged behind the sample-adding arm module and a cup-loading module arranged between the cup-arranging module and the incubation module.

19. The fully automatic chemiluminescence analyzer according to claim 18, characterized in that: The host comprises a reagent tray module and a reagent arm module which are arranged at one side of the incubation module, and the reagent arm module transfers the reagent in the reagent tray module to the reaction cup.

20. The fully automatic chemiluminescence analyzer according to claim 19, characterized in that: The reagent arm module transfers the reagent in the reagent disk module to the reaction cup through a flow system control, and the flow system includes: A dispensing and flushing system, which is used for dispensing samples and reagents, and for flushing sample needles and reagent needles; an acid cleaning system for acid cleaning the sample needle and the reagent needle; and The waste discharge system is used to discharge the cleaning waste liquid.

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