Traditional Chinese medicine composition for treating Alzheimer disease and preparation method of composition

A technology for Alzheimer's disease and a composition, which is applied in the field of traditional Chinese medicine compositions for the treatment of Alzheimer's disease, and can solve problems such as being unable to cope with the occurrence and development of AD symptoms, and unable to fundamentally improve the clinical state of the disease or terminate the disease. , to achieve the effect of improving behavior and learning and memory functions, clear efficacy, and easy preparation

CN111214625AInactive Publication Date: 2020-06-02SHENYANG PHARMA UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2020-06-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a traditional Chinese medicine composition for treating Alzheimer disease and a preparation method of the composition. The composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 120-200 parts of fructus alpiniae oxyphyllae and 30-80 parts of fructus schisandrae chinensis. The composition has the following advantages: (1) the composition can reverse brain damage of Alzheimer disease model mice induced by unilateral intraventricular injection of Abeta1-42 in a dose-dependent manner, and significantly improve learning andmemory disorders by improving the oxidative stress response and neurons induced by the Abeta1-42; and (2) the composition can significantly reduce the levels of IL-1beta and IL-6 in the hippocampus of Alzheimer disease model mice induced by unilateral intraventricular injection of lipopolysaccharide, and the level of IL-1beta in the cortex, and significantly improve the learning and memory disorders.
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Description

Technical field:

[0001] The invention relates to a traditional Chinese medicine composition for treating Alzheimer's disease. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in the following weight proportions: 150 parts of Yizhi and 50 parts of Schisandra chinensis. Background technique:

[0002] Alzheimer's disease (AD) is an insidious, progressive and irreversible central nervous degenerative disease clinically characterized by comprehensive dementia, and it is currently the main cause of dementia. Studies have shown that the incidence rate is the highest among people over 65 years old, and it is predicted that the number of patients will increase by 62% by 2030, that is, there will be 1 billion Alzheimer's patients worldwide. The most important factor affecting AD is age growth. In addition, AD is also affected by many factors, such as: family history, carrying related genes, cardiovascular disease, e...

Examples

Embodiment 1

[0042] Embodiment 1 Chinese medicine composition is to Aβ 1-42 Behavioral experiments of induced AD model mice

[0043] 1. Sample Preparation Method

[0044] Preparation of traditional Chinese medicine composition

[0045] (1) Take each raw material by the following parts by weight: Yizhi 150g, Schisandra 50g;

[0046] (2) Pulverize the phylloxera into a coarse powder, extract with 50% ethanol under reflux, extract twice for 2 hours each time, and combine the extracts. The extract was filtered, and after ethanol was recovered, it was concentrated under reduced pressure to a relative density of 1.10 (measured at 60°C) to obtain clear paste 1;

[0047] (3) Dilute the clear paste 1 with 2 times the weight of water, put it on the HP20 macroporous resin column, elute with distilled water until the eluent is colorless, and then elute with 10 times the weight of 35% alcohol, collect the eluent, reduce Press to recover ethanol and concentrate, dry, and obtain the nootropic extract...

Embodiment 2

[0078] Example 2 Detection of biochemical indicators of Chinese medicine composition on AD model mice induced by Aβ1-42

[0079] 1. Sample Preparation Method

[0080] Preparation of traditional Chinese medicine composition

[0081] (1) Take each raw material by the following parts by weight: Yizhi 200g, Schisandra 30g;

[0082] (2) Pulverize the phylloxera into a coarse powder, extract with 65% ethanol under reflux, extract twice for 2 hours each time, and combine the extracts. The extract was filtered, and after ethanol was recovered, it was concentrated under reduced pressure to a relative density of 1.10 (measured at 60°C) to obtain clear paste 1;

[0083] (3) Dilute the clear paste 1 with 1 times the weight of water, put it on the HP20 macroporous resin column, elute with distilled water until the eluent is colorless, then elute with 10 times the weight of 35% alcohol, collect the eluent, reduce Press to recover ethanol and concentrate, dry, and obtain the nootropic extra...

Embodiment 3

[0095] Embodiment 3 Chinese medicine composition is to Aβ 1-42 Histopathological Observation of Induced AD Model Mice

[0096] 1. Preparation of traditional Chinese medicine composition

[0097] (1) Take each raw material by the following parts by weight: Yizhi 120g, Schisandra 60g;

[0098] (2) Pulverize the phylloxera into a coarse powder, extract with 85% ethanol under reflux, extract twice, each time for 2 hours, and combine the extracts. The extract was filtered, and after ethanol was recovered, it was concentrated under reduced pressure to a relative density of 1.10 (measured at 60°C) to obtain clear paste 1;

[0099] (3) Dilute the clear cream 1 with 1 times the weight of water, put it on the HP20 macroporous resin column, elute with distilled water until the eluent is colorless, then elute with 10 times the weight of 40% alcohol, collect the eluent, reduce Press to recover ethanol and concentrate, dry to obtain the nootropic extract;

[0100] (4) Crush Schisandra c...