A circuit for generating ultra-high voltage positive and negative composite pulse electric field

Abstract

The embodiment of the present invention discloses an ultra-high voltage positive and negative composite pulse electric field generating circuit, which relates to the field of high voltage pulse therapy. The circuit mainly includes: a power module, an electric field generating module, a driving circuit, a control module and an interface circuit. The power module is used to provide positive and negative power, and the electric field generating module is used to increase the power supply voltage to 3000V to provide a bipolar voltage of positive and negative 3000V to reduce muscle tremor. The interface circuit is connected to an external detection device, and the control module is used to collect and process real-time data, and generate a driving signal to drive the electric field generating module to operate. The circuit can solve the problems of inaccurate tumor cell therapy and severe muscle tremor in existing tumor treatment technologies, and further improve the treatment efficiency of tumor cells.

Description

Technical Field

[0001] The embodiments of the present invention relate to the field of high voltage pulse therapy, and in particular to an ultra-high voltage positive and negative composite pulse electric field generating circuit. Background Art

[0002] Nanosecond pulsed electric fields have attracted more and more attention in the biomedical field for their unique "intracellular electroprocessing" effect. The so-called "intracellular electroprocessing" effect refers to the fact that under the action of external nanosecond pulses, cells experience a biological effect that is completely different from the microsecond pulse electroporation phenomenon, that is, there will be no obvious electroporation phenomenon on the cell membrane surface, but a series of functional changes will occur in the cell interior, such as the nucleus and mitochondria, producing a large number of micronuclei, and inducing programmed cell death, also known as "apoptosis". Since tumor cells and normal cells have different resistance values, in the clinical treatment of tumor diseases, using nanosecond pulsed electric fields of different intensities to penetrate tumor cells can kill tumor cells without damaging normal cells, and has a good therapeutic effect.

[0003] However, in the process of treating tumor cells, the existing technology does not pay attention to the fact that tumor cells may change in size as the treatment progresses, resulting in the breakdown current being set insufficient or excessive, thereby damaging normal cells. In addition, during the treatment process using the existing technology, the patient may experience severe muscle tremors, which increases the patient's psychological burden and is not conducive to treatment. Summary of the invention

[0004] The purpose of the embodiment of the present invention is to provide an ultra-high voltage positive and negative composite pulse electric field generating circuit to solve the problems of inaccurate tumor cell treatment and severe muscle tremor in existing tumor treatment technologies.

[0005] To achieve the above objectives, the embodiments of the present invention mainly provide the following technical solutions:

[0006] The embodiment of the present invention provides an ultra-high voltage positive and negative composite pulse electric field generating circuit,

[0007] The circuit includes: a power supply module, which is used to provide positive and negative working voltages for the circuit; an electric field generating module, which is connected to the power supply module and is used to convert the power supply voltage into an ultra-high voltage treatment voltage and provide positive and negative composite pulses, and the output end of the electric field generating module is provided with multiple probe interfaces; a driving circuit, which is connected to the electric field generating module and is used to receive a driving signal and drive the electric field generating module to work according to the driving signal; a control module, which is connected to the driving circuit and is used to generate a driving signal according to clinical data to control the operation of the driving circuit; and an interface circuit, which is connected to the control module and is used to receive clinical data and send the clinical data to the control module.

[0008] Furthermore, the power supply module includes a dual power supply device for generating positive and negative voltages.

[0009] Furthermore, the electric field generating module comprises a composite pulse generating circuit and a voltage boosting circuit, wherein the composite pulse generating circuit is used to generate positive and negative composite pulses, and the voltage boosting circuit is used to convert the power supply voltage into a therapeutic voltage.

[0010] Furthermore, the rising edge and the falling edge of the positive and negative composite pulse are both between 20 and 50 nanoseconds.

[0011] Furthermore, the driving circuit is composed of a driving chip, a first operational amplifier, a second operational amplifier and an adjustable resistor, the driving chip is connected to the same-direction input terminal of the first operational amplifier, the output terminal of the first operational amplifier is connected to the reverse input terminal of the second operational amplifier, the adjustable resistor is connected to the power supply and the same-direction input terminal of the second operational amplifier, and the driving signal is output from the output terminal of the second operational amplifier.

[0012] Furthermore, the control module includes a data acquisition module and a control chip. The data acquisition module includes a complex programmable logic device CPLD, and the control chip includes a single-chip microcomputer. The CPLD collects data and sends it to the single-chip microcomputer for processing. The single-chip microcomputer sends the data to a host computer and receives a discharge signal from the host computer to control the operation of the drive circuit.

[0013] Furthermore, the control module also includes a communication module and a high-voltage output detection module. The communication module is used to communicate with the host computer, and the high-voltage output detection module is used to detect the output voltage of the circuit in real time to feedback the working status of the circuit.

[0014] Furthermore, the interface circuit is provided with an optical fiber input end, an optical fiber output end, an R-wave receiving end and a trigger signal receiving end. The optical fiber input end and the optical fiber output end are used to realize communication between the circuit and an external device, the R-wave receiving end is used to receive the R-wave detected by the electrocardiogram monitor, and the trigger signal receiving end is used to receive the heart rate trigger signal.

[0015] The technical solution provided by the embodiment of the present invention has at least the following advantages:

[0016] An ultra-high voltage positive and negative composite pulse electric field generating circuit provided by an embodiment of the present invention utilizes a dual power supply module to provide positive and negative power supplies, utilizes an electric field generating module to provide ultra-high voltage positive and negative composite pulses, and can ensure that the pulses last for a long time, thereby improving treatment efficiency. The positive and negative voltages can reduce muscle tremors caused by treatment, thereby having better treatment effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1An overall structural diagram of an ultra-high voltage positive and negative composite pulse electric field generating circuit provided in an embodiment of the present invention.

[0018] Figure 2 A composite pulse generating circuit is provided in an embodiment of the present invention.

[0019] Figure 3 A boost circuit is provided in an embodiment of the present invention.

[0020] Figure 4 A driving circuit provided by an embodiment of the present invention.

[0021] Figure 5 An interface circuit provided by an embodiment of the present invention.

[0022] Figure 6 An R wave acquisition circuit provided by an embodiment of the present invention.

[0023] Figure 7 A trigger signal acquisition circuit is provided in an embodiment of the present invention. DETAILED DESCRIPTION

[0024] The following is a description of the implementation of the present invention by means of specific embodiments. Those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification.

[0025] In the following description, specific details such as specific system structures, interfaces, and technologies are provided for illustration rather than limitation so that the present invention is thoroughly understood. However, it should be clear to those skilled in the art that the present invention may be implemented in other embodiments without these specific details. In other cases, detailed descriptions of well-known systems, circuits, and methods are omitted to prevent unnecessary details from obstructing the description of the present invention.

[0026] The embodiment of the present invention provides an ultra-high voltage positive and negative composite pulse electric field generating circuit, referring to Figure 1 The circuit mainly includes: a power supply module 01, an electric field generating module 02, a driving circuit 03, a control module 04 and an interface circuit 05. The power supply module 01 is used to provide positive and negative power supplies, and the electric field generating module 02 is used to increase the power supply voltage to 3000V to provide a bipolar voltage of positive and negative 3000V to reduce muscle tremors. The interface circuit 05 is connected to an external detection device, and the control module 04 collects and processes real-time data, and generates a driving signal to drive the electric field generating module 02 to operate.

[0027] Specifically, the power module 01 uses a dual power supply device that generates positive and negative voltages. The dual power supply device is used to provide a positive and negative 220V working voltage to the circuit for normal operation of the circuit.

[0028] The electric field generation module 02 is connected to the power supply module 01. The electric field generation module 02 includes a composite pulse generation circuit and a boost circuit. The composite pulse generation circuit is used to generate composite pulses, preferably 3 groups of composite pulses. The rising edge and falling edge of the composite pulse are both between 20 and 50 nanoseconds, so that the peak duration is long and a better treatment effect is achieved. The boost circuit is used to convert the power supply voltage into an ultra-high treatment voltage of positive and negative 3000V. The output end of the electric field generation module 02 is provided with a plurality of probe interfaces 06 for connecting the nano knife probe. The probe interface 06 uses a G8NW-2H-12VDC Omron relay to achieve the connection between the nano knife probe and the circuit.

[0029] refer to Figure 2 The structure of the composite pulse generating circuit is mainly as follows: the positive electrode of the power supply is connected to the collector of the switch tube S1 and the cathode of the diode D1, and the negative electrode of the power supply is connected to the anode of the diode D2 and the emitter of the switch tube S2; the emitter of the switch tube S1 is connected to the cathode of the diode D2 and the a end of the coupling inductor Lm at the same time, and the anode of the diode D1 is connected to the collector of the switch tube S2 and the b end of the coupling inductor Lm at the same time. The collector of the switch tube S1 and the cathode of the diode D1 are connected to the positive electrode of the output end with a wire, and the c end of the coupling inductor Lm is connected to the negative electrode of the output end with a wire.

[0030] refer to Figure 3 The boost circuit is mainly composed of a voltage stabilizing circuit composed of a transformer T5, a resistor R12, a diode D8, and a capacitor C10, a voltage stabilizing circuit composed of a resistor R13, a diode D9, and a capacitor C11, a filter circuit composed of a transformer T6, capacitors C12, C13, C14, and a resistor R15, and a transformer T7. The power supply voltage can be output to 3000V.

[0031] refer to Figure 4The driving circuit 03 is connected to the electric field generating module 02, and is used to receive the driving signal and drive the electric field generating module 02 to work according to the driving signal. The driving circuit 03 is composed of a driving chip TPL117, a first operational amplifier U2B, a second operational amplifier U2A and an adjustable resistor R24. The driving chip TPL117 is connected to the same-direction input terminal of the first operational amplifier U2B, and the output terminal of the first operational amplifier U2B is connected to the reverse input terminal of the second operational amplifier U2A. The adjustable resistor R24 ​​connects the 5V power supply and the same-direction input terminal of the second operational amplifier U2A, and the driving signal is output from the output terminal of the second operational amplifier U2A. U2B and U2A use LM358 dual operational amplifiers, which include two independent, high-gain, internal frequency-compensated operational amplifiers, which are suitable for single power supply with a wide power supply voltage range, and are also suitable for dual power supply working mode. Under the recommended working conditions, the power supply current is independent of the power supply voltage. Its scope of use includes sensor amplifiers, DC gain modules and all other occasions where operational amplifiers can be used with a single power supply.

[0032] Furthermore, the control module 04 is connected to the driving circuit 03 and is used to generate a driving signal according to clinical data to control the operation of the driving circuit 03. The clinical data includes the resistance value of tumor cells, the patient's heart rate data, and the waveform of the R wave. The treatment window period of the patient is found by integrating various data.

[0033] The control module 04 includes a data acquisition module and a control chip. The data acquisition module includes a complex programmable logic device CPLD, and the control chip includes a single-chip microcomputer. After the CPLD collects data, it sends it to the single-chip microcomputer for processing. The single-chip microcomputer sends the data to the host computer and receives the discharge signal of the host computer to control the operation of the drive circuit 03. The control module 04 also includes a communication module and a high-voltage output detection module. The communication module is used to communicate with the host computer. The high-voltage output detection module is used to detect the output voltage of the circuit in real time to feedback the working state of the circuit, so as to ensure that the circuit can provide ultra-high voltage and achieve the field strength required for treatment.

[0034] Furthermore, the interface circuit 05 is connected to the control module 04, and is used to receive clinical data and send the clinical data to the CPLD of the control module 04. Figure 5 The interface circuit 05 is provided with an optical fiber input end, an optical fiber output end, an R-wave receiving end and a trigger signal receiving end. The optical fiber input end and the optical fiber output end are used to realize the communication between the circuit and the external device. The R-wave receiving end is used to receive the R-wave detected by the electrocardiogram monitor. The trigger signal receiving end is used to receive the heart rate trigger signal to ensure that the patient can be treated only when the heart is in the contraction period.

[0035] In addition, CPLD also requires R wave acquisition circuit and trigger signal acquisition circuit for data acquisition, refer to Figure 6The R wave acquisition circuit is mainly composed of operational amplifiers U7B and U7A and general circuit components. The reverse input end of U7B and the output end of U7A are connected to the pin interface of CPLD.

[0036] refer to Figure 7 The trigger signal acquisition circuit is mainly composed of operational amplifiers U8B and U8A and common circuit components. The output of U8A and the reverse input of U8B are connected to the pin interface of CPLD. In addition, the R wave acquisition circuit and the trigger signal acquisition circuit are both connected to the IO port of the microcontroller.

[0037] In summary, an ultra-high voltage positive and negative composite pulse electric field generating circuit provided by an embodiment of the present invention utilizes a dual power supply module 01 to provide positive and negative power supplies, utilizes an electric field generating module 02 to provide ultra-high voltage positive and negative composite pulses, and can ensure that the pulse duration is relatively long, thereby improving treatment efficiency. The positive and negative voltages can reduce muscle tremors caused by treatment, thereby having better treatment effects.

[0038] Those skilled in the art will appreciate that in one or more of the above examples, the functions described in the present invention can be implemented using a combination of hardware and software. When software is used, the corresponding functions can be stored in a computer-readable medium or transmitted as one or more instructions or codes on a computer-readable medium. Computer-readable media include computer storage media and communication media, wherein communication media include any media that facilitates the transmission of computer programs from one place to another. Storage media can be any available media that can be accessed by general or special-purpose computers.

[0039] The specific implementation methods described above further illustrate the objectives, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above description is only a specific implementation method of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc. made on the basis of the technical solution of the present invention should be included in the scope of protection of the present invention.

Claims

1. An ultra-high voltage positive and negative composite pulse electric field generating circuit, characterized in that: The circuit comprises: A power module, the power module is used to provide positive and negative operating voltages for the circuit; An electric field generating module, which is connected to the power supply module and is used to convert the power supply voltage into an ultra-high voltage treatment voltage and provide positive and negative composite pulses. The output end of the electric field generating module is provided with a plurality of probe interfaces; A driving circuit, the driving circuit is connected to the electric field generating module, and is used to receive a driving signal and drive the electric field generating module to work according to the driving signal; A control module, the control module is connected to the driving circuit and is used to generate a driving signal according to clinical data to control the operation of the driving circuit; An interface circuit, the interface circuit is connected to the control module and is used to receive clinical data and send the clinical data to the control module; The interface circuit is provided with an optical fiber input end, an optical fiber output end, an R wave receiving end and a trigger signal receiving end. The optical fiber input end and the optical fiber output end are used to realize the communication between the circuit and the external device. The R wave receiving end is used to receive the R wave detected by the electrocardiogram monitor, and the trigger signal receiving end is used to receive the heart rate trigger signal. The R wave acquisition circuit is composed of an operational amplifier U7B and an operational amplifier U7A, and the inverting input terminal of the operational amplifier U7B and the output terminal of the operational amplifier U7A are connected to the pin interface of the CPLD; The trigger signal acquisition circuit is composed of an operational amplifier U8B and an operational amplifier U8A. The output end of the operational amplifier U8A and the reverse input end of the operational amplifier U8B are connected to the pin interface of the CPLD; the R wave acquisition circuit and the trigger signal acquisition circuit are both connected to the IO port of the microcontroller.

2. The ultra-high voltage positive and negative composite pulse electric field generating circuit according to claim 1, characterized in that: The power module includes a dual power supply device for generating positive and negative voltages.

3. The ultra-high voltage positive and negative composite pulse electric field generating circuit according to claim 1, characterized in that: The electric field generating module comprises a composite pulse generating circuit and a voltage boosting circuit, wherein the composite pulse generating circuit is used to generate positive and negative composite pulses, and the voltage boosting circuit is used to convert the power supply voltage into a therapeutic voltage.

4. The ultra-high voltage positive and negative composite pulse electric field generating circuit as claimed in claim 3, characterized in that: The rising edge and the falling edge of the positive and negative composite pulses are both between 20 and 50 nanoseconds.

5. The ultra-high voltage positive and negative composite pulse electric field generating circuit according to claim 1, characterized in that: The driving circuit is composed of a driving chip, a first operational amplifier, a second operational amplifier and an adjustable resistor. The driving chip is connected to the same-direction input terminal of the first operational amplifier, the output terminal of the first operational amplifier is connected to the reverse input terminal of the second operational amplifier, the adjustable resistor is connected to the power supply and the same-direction input terminal of the second operational amplifier, and the driving signal is output from the output terminal of the second operational amplifier.

6. The ultra-high voltage positive and negative composite pulse electric field generating circuit according to claim 1, characterized in that: The control module includes a data acquisition module and a control chip. The data acquisition module includes a complex programmable logic device (CPLD). The control chip includes a single-chip microcomputer. The CPLD collects data and sends it to the single-chip microcomputer for processing. The single-chip microcomputer sends the data to a host computer and receives a discharge signal from the host computer to control the operation of the drive circuit.

7. The ultra-high voltage positive and negative composite pulse electric field generating circuit according to claim 1, characterized in that: The control module also includes a communication module and a high-voltage output detection module. The communication module is used to communicate with the host computer, and the high-voltage output detection module is used to detect the output voltage of the circuit in real time to feedback the working status of the circuit.

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