Controllable iodine 125 particle spiral system release device

Abstract

The present invention discloses a controllable iodine-125 particle spiral system release device. The device comprises a hollow catheter sheath, a push rod, a double-stranded thin wire and a three-dimensional sleeve, the two ends of the three-dimensional sleeve are closed, and radioactive particles are arranged inside; wherein, one end of the push rod and the middle part of the double-stranded thin wire are extended into the catheter sheath from the same end of the catheter sheath, and the other end of the push rod and the two ends of the double-stranded thin wire are located outside the catheter sheath; one end of the three-dimensional sleeve is extended into the catheter sheath from the other end of the catheter sheath, and is connected to the double-stranded thin wire, and can contact the push rod. The controllable iodine-125 particle spiral system release device in the present invention can release the "iodine-125 particle spiral system" into the portal vein, and when the position of the insertion is not suitable, its position can be adjusted or it can be taken out and re-inserted, thereby ensuring that the "iodine-125 particle spiral system" can be smoothly inserted and play the due therapeutic effect.

Description

Technical Field

[0001] The invention relates to the field of medical equipment, and in particular to a controllable iodine 125 particle spiral system releasing device. Background Art

[0002] Portal vein invasion is one of the important biological behaviors of hepatocellular carcinoma (HCC) and an independent factor for poor prognosis in HCC patients; approximately 12.5%-39.7% of patients have portal vein tumor thrombus (PVTT) at diagnosis. Treatments for HCC combined with PVTT include transcatheter arterial chemoembolization (TACE), targeted drugs, and immune checkpoint inhibitors, among which iodine-125 particle intravascular brachytherapy has shown a more definite PVTT inhibition effect.

[0003] At present, the iodine-125 particle intravascular brachytherapy technology for PVTT treatment has developed into various forms, including: percutaneous particle placement, iodine-125 particle spiral system, particle strip, particle strip combined with stent and particle stent, etc. The applicant has applied for an invention patent for the iodine-125 particle spiral system (patent number 2016214490265, patent name "Portal Vein Self-fixing Radioactive Particle Sheath") and obtained authorization. In the actual clinical application process, it is also necessary to release the "iodine-125 particle spiral system" into the human vein through some devices and methods to achieve the therapeutic effect.

[0004] According to all current technologies, the process of inserting the "iodine 125 particle spiral system" into the vein is generally as follows: under ultrasound guidance, percutaneously puncture the secondary branch of the portal vein, introduce the catheter sheath into the main trunk of the portal vein, and send the catheter through the catheter sheath to the superior mesenteric vein or splenic vein for portal vein angiography to determine the location and length of the main trunk cancer thrombus. Adjust the catheter sheath tip to the distal portal vein of the cancer thrombus, and then push the particle spiral system to the cancer thrombus through the catheter sheath, then fix the dilation tube and withdraw the catheter sheath to release the particle spiral system, so that the particle spiral system spans the proximal and distal ends of the main trunk cancer thrombus. Finally, use a spring coil to block the intrahepatic puncture tract.

[0005] Among them, after the "iodine 125 particle spiral system" is partially or completely released into the portal vein, if the implantation position is not suitable, it will lead to the negative effect of reduced therapeutic effect. According to the release method in the prior art, after the "iodine 125 particle spiral system" is implanted, its position cannot be adjusted again or it cannot be taken out and reinserted, so the negative effect cannot be corrected, affecting the therapeutic effect. Summary of the invention

[0006] In order to solve the above problems, the present invention provides a controllable iodine 125 particle spiral system releasing device.

[0007] According to one aspect of the present invention, a controllable "iodine particle spiral system" release device is provided, comprising a hollow catheter sheath, a push rod, a double-strand thin wire and a three-dimensional sleeve, wherein both ends of the three-dimensional sleeve are closed and radioactive particles are arranged inside; wherein one end of the push rod and the middle part of the double-strand thin wire both extend into the catheter sheath from the same end of the catheter sheath, and the other end of the push rod and both ends of the double-strand thin wire are both located outside the catheter sheath; one end of the three-dimensional sleeve extends into the catheter sheath from the other end of the catheter sheath, and is connected to the middle part of the double-strand thin wire, and can contact the push rod.

[0008] The controllable iodine-125 particle spiral system releasing device of the present invention can release the "iodine-125 particle spiral system" into the portal vein, and when the implanted position is not suitable, its position can be adjusted or it can be taken out and reinserted, thereby ensuring that the "iodine-125 particle spiral system" can be successfully implanted and achieve the desired therapeutic effect.

[0009] In some embodiments, the outer diameter of the push rod is the same as the outer diameter of the three-dimensional cannula, so that the push rod can be used to push the three-dimensional cannula conveniently, and the sizes of the catheter sheaths outside the two cannulae can be conveniently set.

[0010] In some embodiments, the double-stranded thin wire is coated with an anticoagulant coating, thereby reducing the risk of thrombosis caused by the double-stranded thin wire entering the human body as a foreign body.

[0011] In some embodiments, one end of the three-dimensional cannula extending into the catheter sheath is provided with a side hole, and the middle part of the double-stranded thin wire passes through the side hole. Thus, the double-stranded thin wire is specifically connected to the three-dimensional cannula by providing the side hole.

[0012] In some embodiments, the inner diameter of the catheter sheath is not less than twice the diameter of the double-stranded fine wire plus the outer diameter of the push rod. Thus, a reasonable size of the catheter sheath is set to facilitate stable installation and movement of the push rod and the double-stranded fine wire.

[0013] In some embodiments, the three-dimensional cannula is a spiral structure, which becomes a straight line after being tightened and can rebound after being relaxed. Thus, the structure and performance of the three-dimensional cannula are set, which is used to be introduced into the portal vein for fixation.

[0014] In some embodiments, the radioactive particles are iodine-125 radioactive particles. Thus, the type of radioactive particles is set. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a schematic structural diagram of a controllable iodine-125 particle spiral system releasing device during release according to one embodiment of the present invention;

[0016] Figure 2 for Figure 1 A partial structural schematic diagram of a controllable iodine-125 particle spiral system release device is shown;

[0017] Figure 3 for Figure 1 Schematic diagram of the structure of the iodine-125 particle spiral system shown.

[0018] In the figure: catheter sheath 1, push rod 2, double-stranded thin wire 3, three-dimensional cannula 4, radioactive seeds 5, side hole 6, abdominal wall 7, liver 8, and branch 9. DETAILED DESCRIPTION

[0019] The present invention will be further described in detail below in conjunction with the accompanying drawings.

[0020] Figure 1 The structure of a controllable iodine-125 particle spiral system release device during release according to an embodiment of the present invention is schematically shown. Figure 2 Shows Figure 1 Partial structure of the controllable iodine 125 particle spiral system release device. Figure 3 Shows Figure 1 The structure of the "iodine 125 particle spiral system" in Figure 1-3 As shown, the release device mainly includes a catheter sheath 1, a push rod 2, a double-stranded thin wire 3 and a three-dimensional sleeve 4. The interior of the catheter sheath 1 is hollow, and the push rod 2, the double-stranded thin wire 3 and the three-dimensional sleeve 4 can be inserted. Among them, the catheter sheath 1 is preferably a 4F catheter sheath, which can also be used to send out a catheter to detect the location and length of the cancer thrombus.

[0021] The push rod 2 has a certain hardness, one end of the push rod 2 extends into the catheter sheath 1 from one end of the catheter sheath 1, and the other end of the push rod 2 is located outside the catheter sheath 1. The size of the end of the push rod 2 located outside the catheter sheath 1 can be set larger to facilitate holding and pushing.

[0022] The middle part of the double-stranded thin wire 3 extends into the catheter sheath 1 from the same end where the push rod 2 extends, and the two ends of the double-stranded thin wire 3 are also located outside the catheter sheath 1. The double-stranded thin wire 3 is coated with an anticoagulant coating to reduce the risk of the double-stranded thin wire 3 entering the human body as a foreign body and forming a thrombus.

[0023] Both ends of the three-dimensional sleeve 4 are closed, and radioactive particles 5 are arranged inside. The radioactive particles 5 are preferably iodine-125 radioactive particles. The three-dimensional sleeve 4 and the radioactive particles 5 together constitute the "iodine-125 particle spiral system" to be released and inserted.

[0024] One end of the three-dimensional cannula 4 (this end is set as the tail end, and the other end is the head end) extends from the other end of the catheter sheath 1 into the catheter sheath 1, and this end of the three-dimensional cannula 4 is connected to the middle part of the double-stranded thin wire 3 inside the catheter sheath 1, and the position of the three-dimensional cannula 4 can be adjusted by pulling the double-stranded thin wire 3. In addition, when the push rod 2 is pushed, it can contact the three-dimensional cannula 4 inside the catheter sheath 1, thereby pushing the three-dimensional cannula 4.

[0025] Preferably, the outer diameter of the push rod 2 is generally set to be the same as the outer diameter of the three-dimensional sleeve 4.

[0026] Preferably, a side hole 5 is provided at the tail end of the three-dimensional sleeve 4 , that is, the end extending into the catheter sheath 1 , and the middle part of the double-strand thin wire 3 passes through the side hole 5 .

[0027] If the inner diameter of the catheter sheath 1 is not less than twice the diameter of the double-stranded thin wire 3 and the sum of the outer diameters of the push rod 2, the push rod 2 and the double-stranded thin wire 3 can be stably arranged and smoothly moved in the catheter sheath 1, and even if the inner diameter of the catheter sheath 1 is equal to twice the diameter of the double-stranded thin wire 3 and the sum of the outer diameters of the push rod 2, the movement of the push rod 2 and the double-stranded thin wire 3 will not be hindered due to factors such as the elasticity of the catheter sheath 1.

[0028] The three-dimensional sleeve 4 is in a three-dimensional spiral structure in a natural state and has elasticity. It can be in a straight line after being tightened, and can rebound to a three-dimensional shape after being relaxed.

[0029] The width of the stereoscopic cannula 4 is generally 10% to 20% larger than the diameter of the main trunk of the portal vein. Therefore, after being inserted, the stereoscopic cannula 4 can compress the inner wall of the portal vein by its own elasticity, thereby achieving the effect of self-fixation in the portal vein. The length of the stereoscopic cannula 4 is generally determined according to the length of the cancer thrombus accumulated in the portal vein.

[0030] The radioactive particle 5 comprises a shell made of titanium metal, in which a silver rod is embedded, and the surface of the silver rod is adsorbed with iodine-125 radioactive nuclide. The length of the shell is 4.5 mm, and a plurality of radioactive particles 5 are generally arranged inside the three-dimensional sleeve 4.

[0031] When using this release device to release the "iodine 125 particle spiral system" into the portal vein, the following steps are generally followed:

[0032] 1) Under ultrasound guidance, the secondary branch of the portal vein is punctured through the abdominal wall 7 and the liver 8, and the catheter sheath 1 of the release device is introduced into the main trunk of the portal vein. The catheter is sent to the superior mesenteric vein or splenic vein through the catheter sheath 1 to perform portal vein angiography to determine the location and length of the main trunk tumor thrombus. For example, on a branch 9, the tip of the catheter sheath 1 is adjusted to the portal vein distal to the tumor thrombus;

[0033] 2) using the three-dimensional sleeve and the radioactive particles 5 to make an "iodine-125 particle spiral system", passing a thin wire through the side hole 5 on the three-dimensional sleeve 4, thereby folding the thin wire into a double-strand thin wire 3 and connecting it to the "iodine-125 particle spiral system";

[0034] 3) Insert the head end of the "iodine 125 particle spiral system" into the catheter sheath 1, ensure that the two ends of the double-stranded thin wire 3 are always located outside the catheter sheath 1, extend the push rod 2 into the catheter sheath 1 to push the "iodine 125 particle spiral system" to the location of the cancer thrombus, then fix the push rod 2 and withdraw the catheter sheath 1 to release the "iodine 125 particle spiral system", so that the "iodine 125 particle spiral system" spans the proximal and distal ends of the trunk cancer thrombus;

[0035] 4) If the position of the "iodine 125 particle spiral system" is correct, loosen one end of the double-stranded thin wire 3 and pull the other end to pull the entire thin wire out of the body, thus completing the release of the "iodine 125 particle spiral system";

[0036] 5) If the position of the "iodine 125 particle spiral system" is not accurate, the "iodine 125 particle spiral system" can be dragged backward to the target position by pulling the double-stranded thin wire 3, or it can be pulled out of the body through the catheter sheath 1 and then the position of the catheter sheath 1 is adjusted and released again; after the position is adjusted correctly, loosen one end of the double-stranded thin wire 3, pull the other end to pull the entire thin wire out of the body, and complete the release of the "iodine 125 particle spiral system".

[0037] The controllable iodine-125 particle spiral system releasing device of the present invention can release the "iodine-125 particle spiral system" into the portal vein, and when the implanted position is not suitable, its position can be adjusted or it can be taken out and reinserted, thereby ensuring that the "iodine-125 particle spiral system" can be successfully implanted and achieve the desired therapeutic effect.

[0038] The above are only some embodiments of the present invention. For those skilled in the art, several modifications and improvements can be made without departing from the creative concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. Controllable iodine 125 particle spiral system release device, characterized by: The invention comprises a hollow catheter sheath (1), a push rod (2), a double-stranded thin wire (3) and a three-dimensional sleeve (4), wherein the outer diameter of the push rod (2) is the same as the outer diameter of the three-dimensional sleeve (4), the two ends of the three-dimensional sleeve (4) are closed, and radioactive particles (5) are arranged inside; wherein one end of the push rod (2) and the middle part of the double-stranded thin wire (3) both extend into the catheter sheath (1) from the same end of the catheter sheath (1), and the other end of the push rod (2) and the two ends of the double-stranded thin wire (3) are They are all located outside the catheter sheath (1); one end of the three-dimensional sleeve (4) extends into the catheter sheath (1) from the other end of the catheter sheath (1), and is connected to the middle part of the double-strand thin wire (3), and can contact the push rod (2); one end of the three-dimensional sleeve (4) extending into the catheter sheath (1) is provided with a side hole (6), the middle part of the double-strand thin wire (3) passes through the side hole (6), and the three-dimensional sleeve (4) is a spiral structure, which becomes a straight line after being tightened and can rebound after being relaxed.

2. The controllable iodine-125 particle spiral system release device according to claim 1, characterized in that: The double-strand thin wire (3) is coated with an anticoagulant coating.

3. The controllable iodine-125 particle spiral system release device according to claim 1, characterized in that: The inner diameter of the catheter sheath (1) is not less than the sum of twice the diameter of the double-stranded fine wire (3) and the outer diameter of the push rod (2).

4. The controllable iodine-125 particle spiral system release device according to claim 1, characterized in that: The radioactive particles (5) are iodine-125 radioactive particles.

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