A cold chain over-temperature timing device and manufacturing method thereof

Abstract

The present invention belongs to the field of temperature monitoring technology, and specifically relates to a cold chain over-temperature timing device and a manufacturing method thereof. The cold chain over-temperature timing device includes a transparent protective layer, a guide layer, a medium migration layer, an elastic switch layer, an adhesive layer and a release layer arranged in sequence from top to bottom. The cold chain over-temperature timing device provided by the present invention uses a low-cost sensor to achieve fully automatic continuous timing monitoring of over-temperature conditions. The monitoring process does not require power supply, and the monitoring results are visible to the naked eye, easy to identify, energy-saving, environmentally friendly, and easy to use. The self-activation design of the pasting process is adopted, and refrigerated transportation is not required before use, which further reduces the cost of use. No special activation operation is required, which prevents the risk of loss of control due to negligence in the manual operation process and inadequate activation execution. It has high reliability and good safety.

Description

Technical Field

[0001] The present invention belongs to the technical field of temperature monitoring, and in particular relates to a cold chain over-temperature timing device and a manufacturing method thereof. Background Art

[0002] Biological products such as blood, vaccines, and seafood need to be transported and stored in a cold chain from production to use to ensure their normal efficacy. Once such products exceed their specified refrigeration temperature for a certain period of time, they will deteriorate. For example, once blood leaves the appropriate storage conditions, there is a risk of bacterial growth or loss of function, which in turn poses a threat to the health of the user. Therefore, monitoring the storage temperature and over-temperature conditions of such products before use has become the key to ensuring product quality and safety.

[0003] Existing cold chain transportation and electronic monitoring technologies are already capable of real-time and remote monitoring. However, due to the capacity and cost limitations of electronic monitoring technology, electronic temperature monitoring is currently mainly used for monitoring large-scale transportation processes, and cannot monitor small-packaged independent products, especially during the final distribution process of the transportation process. After being separated from the electronic system monitoring, the refrigerated environment of the product can only be guaranteed by low-reliability refrigeration devices such as insulation boxes and procedural designs such as manual timing. Due to the large seasonal and regional differences in external environmental temperature, the method of simply relying on the system design time range to determine whether the above products are qualified has a large error. At the same time, the method of relying on simple manual timing has great safety risks.

[0004] The time-temperature indicator uses physical migration and chemical reaction to intuitively present the over-temperature time in the form of a progress bar or color change. It has many advantages such as low cost, high reliability, no reliance on power supply, and small size. It is a useful supplement to the existing cold chain electronic temperature monitoring technology. After nearly 50 years of development, the time-temperature indicator has developed a variety of over-temperature timing sensors including migration type, acid-base reaction type, and polymerization reaction type. Among them, the migration type has been industrialized due to its low cost, high reliability, and high timing accuracy.

[0005] However, existing commercial over-temperature timing sensors have the following problems:

[0006] In order to reduce transportation costs, the existing over-temperature timing sensor adopts a design of activation before use, thereby avoiding the cost problem caused by low-temperature storage and transportation. After the sensor is pasted on the surface of the object to be measured, it is necessary to press and squeeze the inner wall of the liquid reservoir to activate the sensor. This activation method requires special operation steps to achieve. Once the manual operation is negligent and the operation is not performed, the sensor will not play a monitoring role. At this time, the product belongs to the monitoring blind spot; in addition, this activation operation requires the user to apply enough pressure so that the closed membrane of the liquid storage cavity can be broken under pressure to allow enough liquid to flow into the second liquid storage cavity and contact with the migration medium layer. If it is not performed properly, when the crack of the closed membrane is small, the activation mark displayed after activation can also be observed, but due to insufficient amount of migrated liquid, the liquid can only migrate to a certain distance when over-temperature and then stop due to insufficient liquid volume, and over-temperature timing cannot be correctly achieved. At this time, there is a risk of mistaking over-temperature failure products for qualified products. This hidden danger is particularly dangerous for medicines, blood, etc. Summary of the invention

[0007] In view of the problems existing in the background technology, the present invention provides an economical and practical cold chain over-temperature timing device which does not require pressing to activate and can be self-adhesive, and a manufacturing method thereof.

[0008] The invention provides a cold chain over-temperature timing device, comprising a transparent protective layer, a guide layer, a medium migration layer, an elastic switch layer, an adhesive layer and a release layer, which are arranged in sequence from top to bottom, wherein: the transparent protective layer comprises a liquid storage cavity and a closed groove, the liquid storage cavity is used to place and store migration liquid, and the closed groove is used to prevent the migration liquid from flowing; the guide layer is provided with a guide groove and a migration hole, the migration hole is arranged directly below the closed groove, one end of the guide groove is arranged below the liquid storage cavity, and the other end is connected with the migration hole; the medium migration layer comprises a liquid inlet hole and a migration area, the liquid inlet hole is arranged directly below the migration hole, one end of the migration area is connected with the liquid inlet hole, and the other end extends along the medium migration layer; a first protrusion is arranged on the elastic switch layer, the first protrusion passes through the liquid inlet hole and the migration hole in sequence from bottom to top, and the top end of the first protrusion is arranged in the closed groove; the adhesive layer is arranged between the elastic switch layer and the release layer, and the adhesive layer is used to be attached to the object to be tested; a second protrusion is arranged on the release layer, the second protrusion is arranged below the first protrusion, and is used to fix and support the first protrusion so that the top end of the first protrusion remains in the closed groove.

[0009] Furthermore, the cold chain over-temperature timing device provided by the present invention also includes a first medium migration sealing layer and a second medium migration sealing layer. The first medium migration sealing layer is arranged between the medium migration layer and the guide layer, and the second medium migration sealing layer is arranged between the medium migration layer and the elastic switch layer.

[0010] Furthermore, the first medium migration sealing layer is provided with an upper liquid inlet hole, and the second medium migration sealing layer is provided with a lower liquid inlet hole.

[0011] Furthermore, the upper liquid inlet hole is arranged between the migration hole and the liquid inlet hole, the lower liquid inlet hole is arranged below the liquid inlet hole, and the migration hole, the upper liquid inlet hole, the liquid inlet hole and the lower liquid inlet hole constitute a liquid inlet cavity.

[0012] Furthermore, the material of the medium migration layer is a polymer microporous material or a fiber material.

[0013] Furthermore, the elastic switch layer is made of rubber material.

[0014] Furthermore, the migration liquid is a viscous liquid, and the melting point of the migration liquid is the same as the upper limit temperature of the refrigerated storage of the object to be tested.

[0015] Furthermore, before the cold chain over-temperature timing device provided by the present invention is activated, the release layer is arranged below the adhesive layer, the second protrusion fixes the first protrusion in the liquid inlet cavity, the top end of the first protrusion is maintained in the closed groove, and the migration liquid is placed in the liquid storage cavity; after activation, the release layer is peeled off and bonded to the object to be tested through the adhesive layer, the first protrusion returns to a flat state, and the migration liquid flows into the liquid inlet cavity through the guide groove and contacts the medium migration layer.

[0016] Furthermore, when overheated, the migration liquid moves along the migration zone of the medium migration layer.

[0017] The present invention also provides a method for manufacturing a cold chain over-temperature timing device, which is used to manufacture the above-mentioned cold chain over-temperature timing device, and the method comprises: (1) preparing a liquid storage cavity and a closed groove on a transparent polymer film by a hot pressing molding process to form a transparent protective layer, and printing relevant identification information on the surface of the transparent protective layer; (2) preparing a guide groove and a migration hole on the transparent polymer film by a die-cutting process, wherein the opening of the guide groove is opened from the position of the liquid storage cavity to the position of the closed groove, and is connected with the migration hole to form a guide layer; (3) making the polymer fiber into a porous film, and then using a die-cutting process to make a liquid inlet hole below the closed groove to form a migration layer, opening holes at corresponding positions of the two layers of transparent polymer to form a first medium migration sealing layer and a second medium migration sealing layer respectively, sandwiching the porous membrane between the first medium migration sealing layer and the second medium migration sealing layer, and then using a mold with a rectangular non-contact area in the middle to perform hot pressing to make a migration area; (4) aligning and bonding the guide layer and the medium migration layer with the sealing layer , then the elastic rubber film, adhesive and thermoplastic polymer film are bonded in sequence to form a bonded whole from top to bottom, which are the guide layer, the first medium migration sealing layer, the medium migration layer, the second medium migration sealing layer, the elastic switch layer, the bonding layer and the release layer, and the migration hole and the opening of the liquid inlet hole are merged to form a liquid inlet cavity; (5) the liquid storage cavity opening of the transparent protective layer is placed upward, and a migration liquid with a fixed melting point is injected into the liquid storage cavity, and then the guide layer, the first medium migration sealing layer, the medium migration layer, the second medium migration sealing layer, the elastic switch layer, the bonding layer and the release layer are bonded together to the transparent protective layer, and the position of the liquid inlet cavity corresponds to the closed groove; (6) hot pressing bonding is performed, and a combined mold is used during the hot pressing process to form a second protrusion on the release layer, and the second protrusion deforms the elastic switch layer, and the elastic switch layer is pulled up to form a first protrusion, and the first protrusion is inserted and embedded in the liquid inlet cavity, and the top extends into the closed groove; (7) hot pressing bonding is completed to form a cold chain over-temperature timing device.

[0018] The cold chain over-temperature timing device and the manufacturing method thereof provided by the present invention have the following beneficial effects:

[0019] The cold chain over-temperature timing device provided by the present invention adopts a low-cost sensor to realize full-automatic continuous timing monitoring of over-temperature conditions. The monitoring process does not require power supply, and the monitoring results are visible to the naked eye, easy to identify, energy-saving, environmentally friendly, and easy to use. The self-activation design of the pasting process is adopted, and refrigerated transportation is not required before use, which further reduces the cost of use. No special activation operation is required. The release film is torn off and the device can be activated and used by pasting it on the object to be tested through the adhesive layer. There is no need to press the activation step to prevent the risk of loss of control caused by negligence in the manual operation process and inadequate activation execution. It has high reliability and good safety. The movement of the migration liquid can be observed through the transparent protective layer. According to the movement of the migration liquid, it can be judged in real time whether the object to be tested is over-temperature and how long the over-temperature state is maintained. The judgment method is simple, the monitoring results are accurate, and the safety hazards of the items in the cold chain transportation process are reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0021] Figure 1 It is a cross-sectional schematic diagram of the cold chain over-temperature timing device of the present invention before activation;

[0022] Figure 2 It is a cross-sectional schematic diagram of the cold chain over-temperature timing device after activation of the present invention;

[0023] Figure 3 It is a schematic diagram of the transparent protective layer of the cold chain over-temperature timing device of the present invention;

[0024] Figure 4 It is a schematic diagram of the guide layer of the cold chain over-temperature timing device of the present invention;

[0025] Figure 5 It is a schematic diagram of the medium migration layer of the cold chain over-temperature timing device of the present invention;

[0026] Figure 6 It is a side view of the release layer of the cold chain over-temperature timing device of the present invention;

[0027] Figure 7 It is a schematic diagram of the first medium migration sealing layer of the cold chain over-temperature timing device of the present invention;

[0028] Figure 8 It is a schematic diagram of the second medium migration sealing layer of the cold chain over-temperature timing device of the present invention;

[0029] Fig. 9This is a schematic diagram of the cold chain over-temperature timing device of the present invention before activation;

[0030] Fig.10 This is a schematic diagram of the normal temperature after the cold chain over-temperature timing device of the present invention is activated;

[0031] Fig.11 It is a schematic diagram of the cold chain over-temperature timing device of the present invention when the temperature exceeds the limit time;

[0032] Fig.12 It is a schematic diagram of the cold chain over-temperature timing device of the present invention when the temperature exceeds the limit time;

[0033] In the figure: 1-transparent protective layer, 11-liquid storage cavity, 12-sealed groove, 2-guiding layer, 21-guiding groove, 22-migration hole, 3-medium migration layer, 31-liquid inlet hole, 32-migration zone, 33-liquid inlet cavity, 4-elastic switch layer, 41-first protrusion, 5-adhesive layer, 6-release layer, 61-second protrusion, 7-migration liquid, 8-first medium migration sealing layer, 81-upper liquid inlet hole, 9-second medium migration sealing layer, 91-lower liquid inlet hole. DETAILED DESCRIPTION

[0034] The following will be combined with the accompanying drawings in the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work belong to the protection scope of the present invention.

[0035] like Figure 1-Figure 6As shown, the present invention provides a cold chain overtemperature timing device, comprising a transparent protective layer 1, a guide layer 2, a medium migration layer 3, an elastic switch layer 4, an adhesive layer 5 and a release layer 6 arranged in sequence from top to bottom, wherein: the transparent protective layer 1 comprises a liquid storage cavity 11 and a closed groove 12, the liquid storage cavity 11 is used to place and store the migration liquid 7, and the closed groove 12 is used to prevent the migration liquid 7 from flowing; the guide layer 2 is provided with a guide groove 21 and a migration hole 22, the migration hole 22 is arranged directly below the closed groove 12, one end of the guide groove 21 is arranged below the liquid storage cavity 11, and the other end is connected to the migration hole 22; the medium migration layer 3 comprises a liquid inlet hole 31 and a migration area 32 The liquid inlet hole 31 is arranged directly below the migration hole 22, one end of the migration zone 32 is connected to the liquid inlet hole 31, and the other end extends along the medium migration layer 3; a first protrusion 41 is arranged on the elastic switch layer 4, and the first protrusion 41 passes through the liquid inlet hole 31 and the migration hole 22 from bottom to top in sequence, and the top of the first protrusion 41 is arranged in the closed groove 12; the adhesive layer 5 is arranged between the elastic switch layer 4 and the release layer 6, and the adhesive layer 5 is used to be pasted to the object to be tested; a second protrusion 61 is arranged on the release layer 6, and the second protrusion 61 is arranged below the first protrusion 41, and is used to fix and support the first protrusion 41, so that the top of the first protrusion 41 remains in the closed groove 12.

[0036] Specifically, the cold chain over-temperature timing device provided by the present invention is a multi-layer superimposed structure, which includes, from top to bottom, a transparent protective layer 1, a guide layer 2, a medium migration layer 3, an elastic switch layer 4, an adhesive layer 5 and a release layer 6. In an embodiment of the present invention, the transparent protective layer 1 is preferably a transparent polymer film, which is mainly used to store the migration liquid 7 and observe the movement of the migration liquid 7; the guide layer 2 is preferably a transparent polymer film, which is mainly used to allow the migration liquid 7 to flow smoothly, and the migration liquid 7 flows along the guide groove 21, through the migration hole 22, and flows into the medium migration layer 3 below; the medium migration layer 3 mainly relies on capillary action to move the migration liquid 7 along the migration zone 32, and limits the movement time of the migration liquid 7 by the speed of movement and the length of the migration zone 32, so as to determine whether the object to be tested is over-temperature, and whether the over-temperature time exceeds the limit. The shape and length of the migration zone 32 can be determined according to the actual The situation is determined; the elastic switch layer 4 is mainly used to seal the migration liquid 7 before the activation state, and the raised structure on the elastic switch layer 4 is arranged in the closed groove 12, and the migration liquid 7 is sealed in the liquid storage chamber 11 and the guide groove 21 to prevent contact with the medium migration layer 3; before activation, one side of the adhesive layer 5 is bonded to the elastic switch layer 4, and the other side is bonded to the release layer 6. After activation, the release layer 6 is peeled off, and the adhesive layer 5 is pasted to the object to be tested to achieve accurate monitoring of the temperature of the object to be tested; the release layer 6 is preferably made of polycarbonate, which is mainly used to deform the elastic switch layer 4 to form a raised structure and fix the raised structure on the elastic switch layer 4 in the closed groove 12.

[0037] Further, such as Figure 7-Figure 8 As shown, the cold chain overtemperature timing device provided by the present invention further includes a first medium migration sealing layer 8 and a second medium migration sealing layer 9, wherein the first medium migration sealing layer 8 is arranged between the medium migration layer 3 and the guide layer 2, and the second medium migration sealing layer 9 is arranged between the medium migration layer 3 and the elastic switch layer 4. Medium migration sealing layers are also arranged above and below the medium migration layer 3, and the medium migration sealing layers are mainly used to ensure that the migration liquid 7 migrates and diffuses on the medium migration layer 3 at a known speed, and prevent the migration liquid 7 from penetrating and diffusing through the gaps between each layer, thereby causing the timing result to be inaccurate and resulting in timing failure.

[0038] Furthermore, the first medium migration sealing layer 8 is provided with an upper liquid inlet hole 81, and the second medium migration sealing layer 9 is provided with a lower liquid inlet hole 91. After the cold chain overtemperature timing device is activated, the migration liquid 7 flows downward from the migration hole 22 of the guide layer 2, flows through the upper liquid inlet hole 81, the liquid inlet hole 31 and the lower liquid inlet hole 91 in sequence, and contacts with the medium migration layer 3.

[0039] Further, the upper liquid inlet hole 81 is arranged between the migration hole 22 and the liquid inlet hole 31, the lower liquid inlet hole 91 is arranged below the liquid inlet hole 31, and the migration hole 22, the upper liquid inlet hole 81, the liquid inlet hole 31 and the lower liquid inlet hole 91 form a liquid inlet cavity 33. After the cold chain overtemperature timing device is activated, the elastic switch layer 4 returns to flatness, the convex structure disappears, and the migration liquid 7 flows from the liquid storage cavity 11 along the guide groove 21 into the liquid inlet cavity 33 and remains in the liquid inlet cavity 33.

[0040] Furthermore, the material of the medium migration layer 3 is a polymer microporous material or a fiber material. The medium migration layer 3 can be a woven or non-woven, natural or synthetic fiber material. In the embodiment of the present invention, the medium migration layer 3 is preferably a porous membrane made of polyolefin plastic fiber.

[0041] Furthermore, the elastic switch layer 4 is made of rubber material. The elastic switch layer 4 is mainly used to control the blocking migration fluid 7. The rubber material is selected mainly because rubber has good elasticity and can instantly restore deformation. In the embodiment of the present invention, the elastic switch layer 4 is preferably a silicone film.

[0042] Furthermore, the migration liquid 7 is a viscous liquid, and the melting point of the migration liquid 7 is the same as the upper limit temperature of the refrigerated storage of the object to be tested. The melting point of the migration liquid 7 is determined according to the upper limit temperature of the refrigerated storage of the object to be tested, and is generally set to -30°C to 60°C. The migration liquid 7 may contain oil and oil-soluble dyes, or may contain water, water-soluble dyes, and in some cases may also contain chemicals for controlling the viscosity of the liquid. The time for the migration liquid 7 to move in the medium migration layer 3 can be set according to actual conditions, and can be adjusted by adjusting the viscosity of the migration liquid, adjusting the wettability of the migration liquid, adjusting the porosity of the medium migration layer 3, adjusting the thickness and width of the medium migration layer 3, etc.

[0043] Further, such as Figure 9-12 As shown, before the cold chain over-temperature timing device provided by the present invention is activated, the release layer 6 is arranged below the adhesive layer 5, the second protrusion 61 fixes the first protrusion 41 in the liquid inlet cavity 33, the top of the first protrusion 41 is maintained in the closed groove 12, and the migration liquid 7 is placed in the liquid storage cavity 11; after activation, the release layer 6 is peeled off and adhered to the object to be tested through the adhesive layer 5, the first protrusion 41 returns to a flat state, and the migration liquid 7 flows into the liquid inlet cavity 33 through the guide groove 21 and contacts with the medium migration layer 3. Before the cold chain over-temperature timing device provided by the present invention is activated, the first protrusion 41 structure of the elastic switch layer 4 is arranged in the entire liquid inlet cavity 33, and the top of the first protrusion 41 is fixed in the closed groove 12. At this time, the migration liquid 7 is placed in the liquid storage cavity 11. Due to the obstruction of the first protrusion 41 of the elastic switch layer 4, there is no way to flow into the liquid inlet cavity 33; after activation, the release layer 6 is peeled off and bonded to the object to be tested through the adhesive layer 5. The first protrusion 41 on the elastic switch layer 4 returns to a flat state due to the elastic restoring force. Due to the disappearance of the first protrusion 41, the migration liquid 7 can flow, and the migration liquid 7 flows into the liquid inlet cavity 33 along the guide groove 21 on the guide layer 2 and contacts with the medium migration layer 3.

[0044] Furthermore, when the temperature is over-limited, the migration liquid 7 moves along the migration zone 32 of the medium migration layer 3. The release layer 6 is torn off, and the cold chain over-temperature timing device is bonded to the object to be tested through the bonding layer 5. At this time, the cold chain over-temperature timing device is in an activated state, and the position of the migration liquid 7 can be observed through the closed groove 12 on the transparent protective layer 1. At this time, the migration liquid 7 is located in the liquid inlet cavity 33 and is in contact with the medium migration layer 3; Fig.10As shown, when the temperature is normal, the migration liquid 7 will remain in this position and will not move; when the temperature exceeds the upper limit of the refrigeration temperature of the object to be tested, the migration liquid 7 melts, and under the action of the capillary action and surface tension of the medium migration layer 3, the migration liquid 7 will move along the migration area 32, and the timing will start. Through the transparent protective layer 1, the position of the migration liquid 7 can be observed. At this time, when the temperature returns to normal and is lower than the melting point, the migration liquid 7 will solidify in place and the timing will stop. Therefore, whether the object to be tested is overheated and the accumulated overheating time can be judged according to the position of the migration liquid 7. Fig.12 As shown, when the migration liquid 7 completely moves to the end of the migration zone 32, it means that the object to be tested has been overheated, and the overheating time has exceeded the prescribed time limit, and the probability of failure of the object to be tested is high; Fig.11 As shown, when the migration liquid 7 does not move to the end of the migration zone 32, it means that although the object to be tested has been overheated, the overheating time has not exceeded the specified time limit, and the subsequent temperature has dropped. At this time, the probability of failure of the object to be tested is low. In addition, in order to make the migration zone 32 more obvious and the observed results clearer, dyes can be added to the migration liquid 7 for dyeing, or different reagents can be added to the migration liquid 7 and the medium migration layer 3 respectively, so that the two react and change color. At this time, the migration liquid 7 will change color when moving in the migration zone 32, and the observed results will be more obvious.

[0045] The present invention also provides a method for manufacturing a cold chain over-temperature timing device, which is used to manufacture the above-mentioned cold chain over-temperature timing device, and the method comprises: (1) preparing a liquid storage cavity 11 and a closed groove 12 on a transparent polymer film by a hot pressing molding process to form a transparent protective layer 1, and printing relevant identification information on the surface of the transparent protective layer 1, wherein the liquid storage cavity 11 is preferably hemispherical; (2) preparing a guide groove 21 and a migration hole 22 on the transparent polymer film by a die-cutting process, wherein the opening of the guide groove 21 is opened from the position of the liquid storage cavity 11 to the position of the closed groove 12, and is aligned with the migration hole 22. 22 are connected to form a guide layer 2; (3) the polymer fiber is made into a porous film, and then a liquid inlet hole 31 is made below the closed groove 12 by a die-cutting process to form a medium migration layer 3, holes are opened at corresponding positions of the two layers of transparent polymer to form a first medium migration sealing layer 8 and a second medium migration sealing layer 9 respectively, the porous film is sandwiched between the first medium migration sealing layer 8 and the second medium migration sealing layer 9, and then a mold with a rectangular non-contact area in the middle is used for hot pressing to form a migration area 32; (4) the guide layer 2 and the medium migration layer 3 with a sealing layer are aligned and bonded, and then Then, the elastic rubber film, the adhesive and the thermoplastic polymer film are sequentially bonded to form a bonded whole from top to bottom, which is sequentially the guide layer 2, the first medium migration sealing layer 8, the medium migration layer 3, the second medium migration sealing layer 9, the elastic switch layer 4, the bonding layer 5 and the release layer 6, and the migration hole 22 and the opening of the liquid inlet hole 31 are combined to form a liquid inlet cavity 33; (5) the liquid storage cavity 11 of the transparent protective layer 1 is placed upward, and a migration liquid 7 with a fixed melting point and a specific viscosity is injected into the liquid storage cavity 11, and then the guide layer 2, the first medium migration sealing layer 8, the second medium migration sealing layer 9, the elastic switch layer 4, the bonding layer 5 and the release layer 6 are bonded together. The transparent protective layer 1 is bonded to the medium migration layer 8, the medium migration sealing layer 3, the second medium migration sealing layer 9, the elastic switch layer 4, the adhesive layer 5 and the release layer 6, and the position of the liquid inlet cavity 33 corresponds to the position of the closed groove 12; (6) hot pressing bonding is performed, and a combined mold is used during the hot pressing process to form a second protrusion 61 on the release layer 6, and the second protrusion 61 deforms the elastic switch layer 4, and the elastic switch layer 4 is pulled up to form a first protrusion 41, and the first protrusion 41 is inserted and embedded in the liquid inlet cavity 33, and the top end extends into the closed groove 12; (7) the hot pressing bonding is completed to form a cold chain over-temperature timing device.

[0046] The present invention is further described above with the aid of specific embodiments. However, it should be understood that the specific description here should not be construed as limiting the essence and scope of the present invention. Various modifications made to the above embodiments by ordinary technicians in the field after reading this specification are all within the scope of protection of the present invention.

Claims

1. A cold chain overtemperature timing device, characterized in that: It includes a transparent protective layer, a guide layer, a medium migration layer, an elastic switch layer, a bonding layer and a release layer arranged in sequence from top to bottom, wherein: The transparent protective layer comprises a liquid storage cavity and a closed groove, wherein the liquid storage cavity is used to store the migration liquid, and the closed groove is used to prevent the migration liquid from flowing; The guide layer is provided with a guide groove and a migration hole, wherein the migration hole is arranged directly below the closed groove, one end of the guide groove is arranged below the liquid storage cavity, and the other end is connected with the migration hole; The medium migration layer comprises a liquid inlet hole and a migration zone, wherein the liquid inlet hole is arranged directly below the migration hole, one end of the migration zone is connected to the liquid inlet hole, and the other end extends along the medium migration layer; The elastic switch layer is provided with a first protrusion, the first protrusion passes through the liquid inlet hole and the migration hole in sequence from bottom to top, and the top end of the first protrusion is arranged in the closed groove; The adhesive layer is disposed between the elastic switch layer and the release layer, and is used to adhere to the object to be tested; The release layer is provided with a second protrusion, which is arranged below the first protrusion and is used to fix and support the first protrusion so that the top end of the first protrusion is kept in the closed groove.

2. The cold chain overtemperature timing device according to claim 1, characterized in that: It also includes a first medium migration sealing layer and a second medium migration sealing layer, wherein the first medium migration sealing layer is arranged between the medium migration layer and the guide layer, and the second medium migration sealing layer is arranged between the medium migration layer and the elastic switch layer.

3. The cold chain overtemperature timing device according to claim 2, characterized in that: The first medium migration sealing layer is provided with an upper liquid inlet hole, and the second medium migration sealing layer is provided with a lower liquid inlet hole.

4. The cold chain overtemperature timing device according to claim 3, characterized in that: The upper liquid inlet hole is arranged between the migration hole and the liquid inlet hole, the lower liquid inlet hole is arranged below the liquid inlet hole, and the migration hole, the upper liquid inlet hole, the liquid inlet hole and the lower liquid inlet hole form a liquid inlet cavity.

5. The cold chain overtemperature timing device according to claim 1, characterized in that: The material of the medium migration layer is a polymer microporous material or a fiber material.

6. The cold chain over-temperature timing device according to claim 1, characterized in that: The elastic switch layer is made of rubber material.

7. The cold chain over-temperature timing device according to claim 1, characterized in that: The migration liquid is a viscous liquid, and the melting point of the migration liquid is the same as the upper limit temperature of the refrigerated storage of the object to be tested.

8. The cold chain overtemperature timing device according to claim 4, characterized in that: Before activation, the release layer is arranged below the adhesive layer, the second protrusion fixes the first protrusion in the liquid inlet cavity, the top end of the first protrusion is maintained in the closed groove, and the migration liquid is placed in the liquid storage cavity; after activation, the release layer is peeled off and adhered to the object to be tested through the adhesive layer, the first protrusion returns to a flat state, and the migration liquid flows into the liquid inlet cavity through the guide groove and contacts the medium migration layer.

9. The cold chain overtemperature timing device according to claim 8, characterized in that: When over-temperature occurs, the migration liquid moves along the migration zone of the medium migration layer.

10. A method for manufacturing a cold chain over-temperature timing device, characterized in that: The method is used to manufacture the cold chain overtemperature timing device according to any one of claims 1 to 9, and the method comprises: (1) A liquid storage cavity and a closed groove are prepared on a transparent polymer film by a hot pressing molding process to form a transparent protective layer, and relevant identification information is printed on the surface of the transparent protective layer; (2) preparing a guide groove and a migration hole on a transparent polymer film by a die-cutting process, wherein the opening of the guide groove is opened from the position of the liquid storage cavity to the position of the closed groove and is connected with the migration hole to form a guide layer; (3) the polymer fiber is made into a porous membrane, and then a liquid inlet hole is made below the closed groove by a die-cutting process to form a migration layer, holes are opened at corresponding positions of the two layers of transparent polymer to form a first medium migration sealing layer and a second medium migration sealing layer respectively, the porous membrane is sandwiched between the first medium migration sealing layer and the second medium migration sealing layer, and then a mold with a rectangular non-contact area in the middle is used for hot pressing to form a migration zone; (4) aligning and bonding the guide layer and the medium migration layer with the sealing layer, and then bonding the elastic rubber film, the adhesive and the thermoplastic polymer film in sequence to form a bonded whole from top to bottom, which is the guide layer, the first medium migration sealing layer, the medium migration layer, the second medium migration sealing layer, the elastic switch layer, the adhesive layer and the release layer, and the migration hole and the opening of the liquid inlet hole are combined to form a liquid inlet cavity; (5) placing the liquid storage cavity opening of the transparent protective layer upward, injecting a migration liquid with a fixed melting point into the liquid storage cavity, and then bonding the guiding layer, the first medium migration sealing layer, the medium migration layer, the second medium migration sealing layer, the elastic switch layer, the adhesive layer and the release layer to the transparent protective layer, with the position of the liquid inlet cavity corresponding to the closed groove; (6) performing hot pressing bonding, wherein a combined mold is used during the hot pressing process to form a second protrusion on the release layer, wherein the second protrusion deforms the elastic switch layer, and the elastic switch layer is pulled up to form a first protrusion, wherein the first protrusion is inserted and embedded in the liquid inlet cavity, and the top end extends into the closed groove; (7) Hot pressing and bonding is completed to form a cold chain over-temperature timing device.

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