A detection device

Abstract

The present invention discloses a detection device, which includes a first chamber located inside the cup body for collecting liquid samples; a second chamber located inside the sample bottle; a first hole for communicating the second chamber and the first chamber; and a rotatable sealing element; the rotation of the sealing element enables the first chamber and the second chamber to be in a communicating state and a non-communicating state. On the basis of the basic functions of collecting and detecting samples, the detection device also has the function of collecting samples into the sample bottle for secondary detection. The sample bottle can be separately disassembled from the inside of the detection device. Therefore, the samples in the sample bottle will definitely not be affected by the test elements in the detection device, ensuring the purity of the retained samples.

Description

Technical Field

[0001] The present invention relates to the field of detection, and particularly to a device capable of performing detection and collection. Background Art

[0002] The following introduction to the background art is only an introduction to some common background knowledge and will not constitute any limitation to the present invention.

[0003] Currently, detection devices for detecting whether an analyte is contained in a sample are widely used in hospitals or at home. These detection devices for rapid diagnosis include one or more test strips, such as early pregnancy detection, drug abuse detection, and so on. Such rapid diagnosis detection devices are very convenient and can obtain detection results on the test strip in one minute, or at most about ten minutes.

[0004] Drug detection is widely used in institutions such as anti-drug departments, public security bureaus, drug rehabilitation centers, physical examination centers, and national military conscription physical examination offices. There are various types of drug detections and frequent detections. There is a huge market demand for a urine cup for drug detection that can automatically separate the remaining sample from the detected sample. After the detection is completed, the sample in the urine cup on the market will be contaminated by the detection reagent and cannot be used for a second confirmation test, as described in, for example, US Patent 7300633.

[0005] In the prior art, there are a large number of disposable detection devices that integrate collection and detection. For example, as described in Chinese Patent 2008103055231, it includes a cup body (equivalent to a collection chamber), and a test plate containing a test strip (equivalent to a detection chamber) is provided on the side of the cup body. The area where the cup body and the test plate are located can be connected. As described in paragraph 0005 of the specification of this document, the person to be tested places urine in the urine cup. At this time, the positioning component controls the liquid outlet on the test plate to be not connected to the communication hole on the cup body. When the person to be tested needs to perform a test, the tester adjusts the positioning component to connect the liquid outlet to the communication hole, and at the same time inverts the cup body, and the urine flows into the test strip cavity to autonomously start the reaction. When the reaction ends, the result is interpreted and recorded, and the urine cup is placed upright, realizing the separation of the urine in the detection area from the urine in the urine cup. Although this detection device can achieve the separation of the urine in the detection area from the urine in the urine cup, this form of separation is not thorough. The separation of the urine in the detection area from the urine in the urine cup is essentially still within the same detection device, which is very inconvenient. For example: The operator needs to retain the urine in the urine cup for subsequent secondary testing. At this time, he either saves it together with the detection area (whether the test agent in the detection area will generate and / or volatilize substances that affect the urine in the urine cup is unknown to us); or extracts a part of the urine in the urine cup and stores it in another collection container (although this method can ensure that the sample is not contaminated, the operation is relatively cumbersome).

[0006] In view of these technical problems above, it is necessary to improve them and provide another way to solve the deficiencies of the existing traditional technologies. Summary of the Invention

[0007] The technical problem to be solved by the present invention is to provide a detection device for solving the above technical problems.

[0008] The technical solution adopted by the present invention to solve the above technical problems is: A detection device includes a first chamber located inside the cup body for collecting liquid samples; a second chamber located inside the sample bottle; a first hole for connecting the second chamber and the first chamber; and a rotatable sealing element; the connection state and non-connection state between the first chamber and the second chamber are achieved by the rotation of the sealing element.

[0009] Further, a second hole is provided on the sealing element. When the sealing element rotates, the switching between the connection state and non-connection state of the first hole and the second hole occurs; when the first hole and the second hole are connected, the first chamber and the second chamber are connected; when the first hole and the second hole are not connected, the first chamber and the second chamber are not connected.

[0010] Further, the sealing element is detachable.

[0011] Further, the sample bottle is detachable. When the sample bottle is removed, the first chamber is separated from the second chamber.

[0012] Further, the sample bottle and the sealing element are detachably connected, so that the second chamber and the sealing element are detachably connected.

[0013] Further, the sealing element and the cup body are detachably connected, so that the sealing element and the first chamber are detachably connected.

[0014] Further, the sample bottle can rotate relative to the cup body, and the rotation of the sample bottle drives the rotation of the sealing element; alternatively, the sealing element is located on the sample bottle, and the movement of the sample bottle drives the movement of the sealing element.

[0015] Further, the sample bottle includes a bottle mouth, and a groove is provided on the bottle mouth. A first post is provided on the sealing element, and the first post can be snapped into the groove; alternatively, the sample bottle includes a bottle mouth, and the sealing element and the sample bottle are connected in a snap-fit manner.

[0016] Further, a helix is provided at the position of the bottle mouth of the sample bottle, and the groove is located at the helix position.

[0017] Further, at least two grooves are provided at the position of the bottle mouth of the sample bottle. Correspondingly, at least two first posts are provided.

[0018] Further, a notch is provided on the cup body, and a second post is provided on the sealing element. By rotating the sealing element, the second post can be snapped into the notch.

[0019] Further, the sealing element has two rotation directions. When the sealing element rotates in one direction, the second post can be snapped into the notch; when the sealing element rotates in the other direction, the second post cannot be snapped into the notch.

[0020] Further, after the second post rotates in one direction and is snapped into the notch, the second post abuts against the notch, and the sealing element cannot continue to rotate in this direction.

[0021] Further, the first post is perpendicular to the second post.

[0022] Further, the sealing element is located at the junction of the cup body and the sample bottle. A part of the sealing element is in contact with the cup body, and a part of the sealing element is in contact with the sample bottle. The side of the sealing element in contact with the cup body is made of a soft material, and the side of the sealing element in contact with the sample bottle is made of a hard material.

[0023] Further, a bottom tray is further included, and the bottom tray is detachably connected to the cup body.

[0024] Further, when the bottom tray is installed on the cup body, the bottom tray can rotate, thereby driving the rotation of the sample bottle.

[0025] Further, the bottom tray is provided with clamping points, and the cup body is provided with fixing grooves, and the clamping points can move along the fixing grooves.

[0026] Further, the fixing grooves are divided into vertical sections and horizontal sections, and one fixing groove at least includes one horizontal section and two vertical sections.

[0027] Further, the vertical sections connect the two ends of the horizontal section, and the arc angles formed by the two vertical sections on the cup body are ninety degrees.

[0028] Further, two fixing grooves are symmetrically arranged at the center of the cup body.

[0029] Further, the bottom tray is detachably connected to the sample bottle, the sample bottle can rotate along with the rotation of the bottom tray, and the sealing element can rotate along with the rotation of the bottom tray.

[0030] The beneficial effects of the present invention are as follows: On the basis of the basic functions of collecting and detecting samples, the detection device of the present invention also has the function of collecting samples into the sample bottle for secondary detection. The sample bottle can be separately disassembled from the inside of the detection device. Therefore, the sample in the sample bottle will definitely not be affected by the test elements in the detection device, ensuring the purity of the retained sample; by quantifying the volume of the sample bottle, the volume of the collected sample can be accurately controlled, facilitating subsequent secondary quantitative detection, and the obtained detection results are true, reliable and have high accuracy; in addition, the detection device of the present invention is exquisitely designed, and the usage method is simple and easy to operate. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 is a schematic diagram of the overall structure of a detection device;

[0032] Figure 2 is Figure 1 the exploded view of

[0033] Figure 3 is a schematic diagram when adding samples into the detection device with the cup lid in the open state;

[0034] Figure 4 is a connection schematic diagram of the bottom tray, the sample bottle and the sealing element;

[0035] Figure 5 is a schematic diagram of the structure of the cup body;

[0036] Figure 6 is a connection schematic diagram when the bottom tray, the sample bottle and the sealing element are installed on the cup body;

[0037] Figure 7 is a working state diagram of the sealing element when the sample bottle is cut open;

[0038] Figure 8 is Figure 7 the top view of

[0039] Figure 9 This is another working state diagram of the sealing element when the sample bottle is cut open;

[0040] Figure 10 yes Figure 9 A top view of

[0041] Figure 11 This is another working state diagram of the sealing element when the sample bottle is cut open;

[0042] Figure 12 yes Figure 11 A top view of

[0043] Figure 13 It is a schematic diagram of the sample bottle after the sample is taken out;

[0044] Figure 14 It is a schematic diagram of the sample bottle after it is separated from the detection device. Detailed Description

[0045] The structures involved in the present invention or the technical terms used are further explained below. If not specifically specified, they are understood and interpreted according to the general terms commonly used in the art.

[0046] Detection

[0047] Detection means to test or examine a substance or material for the presence or absence of a substance or material, such as, but not limited to, a chemical substance, an organic compound, an inorganic compound, a metabolite, a drug or a drug metabolite, an organic tissue or a metabolite of an organic tissue, a nucleic acid, a protein, or a polymer. In addition, detection means to test the amount of a substance or material. Furthermore, assay also means immunoassay, chemical assay, enzyme assay, etc.

[0048] sample

[0049] The detection device of the present invention or the collected sample includes biological liquids (such as case liquids or clinical samples). Liquid samples or liquid specimens, or fluid samples or fluid specimens, can be derived from solid or semi-solid samples, including excreta, biological tissues, and food samples. Any suitable method can be used to convert solid or semi-solid samples into liquid samples, such as mixing, mashing, macerating, incubating, dissolving, or digesting solid samples by enzymatic action in a suitable solution (such as water, phosphate solution, or other buffer solutions). "Biological samples" include those derived from animals, plants, and food samples, such as urine, saliva, blood and its components, cerebrospinal fluid, vaginal secretions, sperm, feces, sweat, secretions, tissues, organs, tumors, cultures of tissues and organs, cell cultures, and media derived from humans or animals. Preferably, the biological sample is urine, and more preferably, the biological sample is saliva. Food samples include food processing substances, end products, meat, cheese, wine, milk, and drinking water. Plant samples include those derived from any plant, plant tissue, plant cell culture, and media. "Environmental samples" are derived from the environment (e.g., liquid samples from lakes or other water bodies, sewage samples, soil samples, groundwater, seawater, and waste liquid samples). Environmental samples can also include sewage or other wastewater.

[0050] Test element

[0051] As used herein, a "test element" refers to any element that can detect whether a sample or specimen contains an analyte of interest, and such detection can be based on any technical principle, such as immunology, chemistry, electrochemistry, optics, molecular biology, nucleic acids, physics, etc. The test element can be a lateral flow test strip, which can detect multiple analytes. Of course, other suitable test elements can also be used in the present invention.

[0052] Various test elements can be combined and used in the present invention. One form is the test strip. The test strip for analyzing analytes (such as drugs or metabolites indicating physical conditions) in a sample can be in various forms, such as immunoassay or chemical analysis forms. The test strip can adopt non-competitive or competitive analysis modes. The test strip generally includes a water-absorbing material with a sample application area, a reagent area, and a test area. The sample is added to the sample application area and flows to the reagent area by capillary action. In the reagent area, if the analyte is present, the sample binds to the reagent. Then the sample continues to flow to the detection area. Some other reagents, such as molecules specifically binding to the analyte, are immobilized in the detection area. These reagents react with the analyte (if present) in the sample and bind the analyte in this area, or bind to one of the reagents in the reagent area. The marker for displaying the detection signal is present in the reagent area or a separate marker area.

[0053] A typical non-competitive assay analysis mode is that if the analyte is present in the sample, a signal will be generated; if the analyte is not present, no signal will be generated. In a competitive assay, if the analyte is not present in the sample, a signal is generated; if the analyte is present, no signal is generated.

[0054] The test element can be a test strip, and materials that absorb water or do not absorb water can be selected. The test strip can include various materials for liquid sample transfer. One material of the test strip can cover another material, such as filter paper covering a nitrocellulose membrane. One or more materials can be selected for one area of the test strip, while other different one or more materials can be selected for another area. The test strip can be adhered to a certain support or a hard surface to improve the strength of holding the test strip.

[0055] The analyte is detected through a signal generation system. For example, one or more enzymes that specifically react with the analyte are used. Using the method of fixing specific binding substances on the test strip as described above, a composition of one or more signal generation systems is fixed in the analyte detection area of the test strip. The substance that generates the signal can be in the sample addition area, the reagent area, or the detection area, or throughout the entire test strip. This substance can fill one or more materials of the test strip. A solution containing the signal substance is added to the surface of the test strip or one or more materials of the test strip are immersed in a solution containing the signal substance. The test strip with the added signal substance solution is dried.

[0056] The various areas of the test strip can be arranged in the following manner: sample addition area, reagent area, detection area, control area, area for determining whether the sample is adulterated, liquid sample absorption area. The control area is located after the detection area. All areas can be arranged on a single test strip using only one material. Or different areas can use different materials. Each area can be in direct contact with the liquid sample, or different areas can be arranged according to the flow direction of the liquid sample, connecting the ends of each area to the front end of another area and overlapping. The materials used can be materials with good water absorption, such as filter paper, glass fiber, or nitrocellulose membrane, etc. The test strip can also be in other forms.

[0057] Generally, the commonly used test strip is a nitrocellulose membrane test strip, that is, the detection area includes a nitrocellulose membrane, and specific binding molecules are fixed on the nitrocellulose membrane to display the detection result; it can also be a cellulose acetate membrane, a nylon membrane, etc. For example, some test strips or devices containing test strips described in the following patents: US 4857453; US 5073484; US5119831; US 5185127; US 5275785; US 5416000; US 5504013; US 5602040; US 5622871; US5654162; US 5656503; US 5686315; US 5766961; US 5770460; US 5916815; US 5976895; US6248598; US 6140136; US 6187269; US 6187598; US 6228660; US 6235241; US 6306642; US6352862; US 6372515; US 6379620; and US 6403383. The test strips and similar devices with test strips disclosed in the above patent documents can all be applied to the test element or detection device of the present invention for detecting the analyte, such as detecting the analyte in a sample.

[0058] The detection reagent strip applied to the present invention may be the commonly referred to lateral flow test strip. The specific structures and detection principles of these detection reagent strips are well-known technologies to those of ordinary skill in the art in the prior art. A common detection reagent strip includes a sample collection area or a sample addition area, a labeling area, a detection area, and a water absorption area. The sample collection area includes a sample receiving pad, the labeling area includes a labeling pad, and the water absorption area may include a water absorption pad. Among them, the detection area includes the necessary chemical substances for detecting whether the analyte is contained, such as immunoassay reagents or enzyme chemical reagents. Commonly used detection reagent strips are nitrocellulose membrane reagent strips, that is, the detection area includes a nitrocellulose membrane, and specific binding molecules are fixed on the nitrocellulose membrane to display the detection results; it can also be a cellulose acetate membrane or a nylon membrane, etc. Of course, a detection result control area may also be included downstream of the detection area. Usually, the control area and the detection area appear in the form of horizontal lines as the test line or the control line. Such a detection reagent strip is a traditional reagent strip. Of course, it can also be other types of reagent strips that utilize capillary action for detection. In addition, generally, the detection reagent strip has dry chemical reagent components, such as fixed antibodies or other reagents. When encountering a liquid, the liquid flows along the reagent strip through capillary action. As it flows, the dry reagent components dissolve in the liquid, and then react with the dry reagents in the next area to perform the necessary detection. The liquid flow is mainly carried out through capillary action. All of these can be applied to the detection device of the present invention, or be arranged in the detection chamber to contact the liquid sample, or be used to detect whether the analyte exists or the quantity of the analyte existing in the liquid sample entering the detection chamber.

[0059] analyte

[0060] Examples of analytes involved in the present invention that can be detected include some small molecule substances, which include drugs (such as drugs of abuse). "Drugs of abuse" (DOA) refers to the non-medical use of drugs (usually acting as nerve paralytics). The abuse of these drugs can cause physical and mental damage, dependence, addiction and / or death. Examples of drug abuse include cocaine; amphetamine AMP (e.g., black beauties, white amphetamine tablets, dextroamphetamine, dextroamphetamine tablets, Beans); methamphetamine MET (crank, meth, crystal, speed); barbiturates BAR (such as Valium, Roche Pharmaceuticals, Nutley, New Jersey); sedatives (i.e., sleep aids); lysergic acid diethylamide (LSD); depressants (downers, goofballs, barbs, blue devils, yellow jackets, methaqualone); tricyclic antidepressants (TCA, i.e., imipramine, amitriptyline, and doxepin); 3,4-methylenedioxymethamphetamine (MDMA); phencyclidine (PCP); tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); opiates (i.e., morphine MOP or opium, cocaine COC, heroin, hydrocodone); anxiolytics and sedative-hypnotics. Anxiolytics are a class of drugs mainly used to reduce anxiety, tension, fear, stabilize mood, and have hypnotic and sedative effects, including benzodiazepines BZO (benzodiazepines), atypical BZ classes, fused diazepines NB23C classes, benzazepines, ligands of BZ receptors, open-ring BZ classes, diphenylmethane derivatives, piperazine carboxylates, piperidine carboxylates, quinazolinones, thiazine and thiazole derivatives, other heterocyclic classes, imidazole-type sedative / analgesics (such as hydrocodone OXY, methadone MTD); propylene glycol derivatives - carbamates, aliphatic compounds, anthracene derivatives, etc. The test kit of the present invention can also be used to detect drugs that are for medical use but are prone to overdose, such as tricyclic antidepressants (imipramine or analogs) and acetaminophen. These drugs are metabolized into small molecule substances after being absorbed by the human body, and these small molecule substances are present in body fluids such as blood, urine, saliva, sweat, etc. or some of these small molecule substances are present in some of these body fluids.

[0061] For example, the analytes detected by the present invention include, but are not limited to, creatinine, bilirubin, nitrite, protein (non-specific), hormones (e.g., human chorionic stimulating hormone, progesterone hormone, follicle stimulating hormone, etc.), blood, white blood cells, sugars, heavy metals or toxins, bacterial substances (e.g., protein or sugar substances for specific bacteria, such as Escherichia coli 0157:H7, Staphylococcus, Salmonella, Clostridium, Campylobacter, L.monocytogenes, Vibrio, or Bacillus cereus) and substances related to physiological characteristics in urine samples, such as pH and specific gravity. Any other clinical urine chemistry analysis can be detected using the lateral flow detection format in conjunction with the device of the present invention.

[0062] Cup body and lid

[0063] See attached Figures 1-3 A detection device includes a cup body 10 and a cup cover 20. The cup cover 20 is used to cover the cup body 10. A first cavity 11 is provided in the cup body 10. The first cavity 11 includes a first opening. The first cavity 11 can also be called a detection cavity, which is used to detect the analyzed substance in the sample. When the cup cover 20 covers the cup body 10, the first cavity 11 is sealed to prevent the sample from leaking. Specifically, the cup body 10 and the cup cover 20 are connected by a threaded fit. The difference is that the cup cover 20 is provided with a first stopper 21, and the cup body 10 is provided with a second stopper 22. When the cup body 10 and the cup cover 20 are just tightened, the first cavity 11 has been sealed, and the first stopper 21 is abutted against the second stopper 22, and the cup body 10 and the cup cover 20 can no longer be tightened. This design is to avoid the cup body 10 and the cup cover 20 from being too tight due to continued screwing, which brings unnecessary trouble to the subsequent opening of the cup cover 20 for detection.

[0064] Preferably, a mark 23 is provided on the cup cover 20 , and the mark 23 helps the operator to distinguish the screwing direction of the cup cover 20 .

[0065] Cup and sample bottle

[0066] See attached Figure 2 , Attachment Figures 4-6 The detection device also includes a sample bottle 30, and a second cavity 31 is provided in the sample bottle 30. The second cavity 31 can also be called a liquid storage cavity. The second cavity 31 can be connected to the first cavity 11, and is used to retain some samples entering the detection cavity for secondary detection. Specifically, a third cavity 12 is provided in the cup body 10 at the lower side of the first cavity 11. The third cavity 12 includes a third opening. The opening directions of the first opening and the third opening are opposite. The sample bottle 30 is located in the third cavity 12. A first hole 13 is provided between the first cavity 11 and the third cavity 12. The first hole 13 is opposite to the second cavity 31. The sample can enter the sample bottle 30 in the third cavity 12 through the first hole 13 to retain the sample.

[0067] To prevent the sample bottle 30 from being exposed to the outside world and to fix the sample bottle 30, the detection device further includes a bottom tray 40. A fixing buckle 41 is provided inside the bottom tray 40, and the fixing buckle 41 is used to fix the sample bottle 30. Specifically, the contour of the bottle body of the sample bottle 30 is square, and there is a circular depression 32 provided thereon. There are also four fixing buckles 41, which are distributed in a square shape. There are raised strips 42 on the fixing buckles 41, and the sample bottle 30 is detachably connected to the bottom tray 40 through the fixing buckles 41 and the raised strips 42.

[0068] The bottom tray 40 is in the shape of a lid and is detachably connected to the cup body 10, and can cover the third cavity 12. The space (the third cavity 12) formed by assembling the bottom tray and the cup body 10 can wrap the sample bottle inside. Since the cup lid 20 is already fixed on the cup body 10, there is not enough space on the upper side of the cup body 10. The simplest way is to set the bottom tray 40 on the lower side part of the cup body 10, which is also the reason why the third cavity 12 is located on the lower side of the first cavity 11. There is a clamping point 43 on the bottom tray 40, and a fixing groove 14 is provided on the cup body 10. The clamping point 43 can move along the fixing groove 14. The fixing groove 14 is divided into a vertical section 16 and a horizontal section 15. The clamping point 43 on the bottom tray 40 first moves along the vertical section 16, and after moving to the end, it rotates into the horizontal section 15. At this time, the bottom tray 40 will not fall off the cup body 10 under the action of gravity, realizing the covering of the bottom tray 40 and the third cavity 12.

[0069] Since the bottom tray 40 needs to rotate on the cup body 10, preferably both the cup body 10 and the bottom tray 40 are circular. Since the sample bottle 30 is detachably connected to the bottom tray 40, during the above process, the sample bottle 30 will rotate with the rotation of the bottom tray 40. To ensure the stability of the fixation of the bottom tray 40 on the cup body 10, two fixing grooves 14 are provided on the cup body 10 in central symmetry. Correspondingly, there are also two clamping points 43 on the bottom tray 40, spaced 180 degrees apart.

[0070] The sample bottle 30 is detachable. After the sample in the second cavity 31 of the sample bottle 30 is collected, the bottom tray 40 can be removed, and then the sample bottle 30 can be removed from the bottom tray 40. It should be noted that if there is no partition between the first cavity 11 and the second cavity 31, that is, the sample in the first cavity 11 is always in communication with the sample in the second cavity 31, then before removing the sample bottle 30 and the bottom tray 40, the sample in the first cavity 11 of the cup body 10 needs to be emptied first. The emptying method can be pouring, pumping, etc. The sample bottle 30 can be removed only after there is no sample in the first cavity 11. At this time, no sample will leak from the first cavity 11 to pollute the outside world.

[0071] The sample bottle 30 includes a bottle mouth 33. A screw thread 34 is provided at the position of the bottle mouth 33 of the sample bottle 30. There is a vacant slot 27 on the cup cover 20. An installation slot 24 is provided in the vacant slot 27. A hollow connecting column 25 is provided in the installation slot 24. A bottle cap 26 is sleeved on the connecting column 25. The bottle cap 26 is not easily detached from the connecting column 25. And the operator can take out the bottle cap 26 in the installation slot 24 by putting a finger into the vacant slot 27. The bottle cap 26 is in screw-threaded engagement with the screw thread 34 of the bottle mouth 33. When the sample bottle 30 is removed, it can seal the sample bottle 30 to prevent the sample reserved in the second cavity 31 from being contaminated. At this time, the second cavity 31 is independent of the device and can be stored separately.

[0072] The sealing element between the cup body and the sample bottle

[0073] The connection mode between the above-mentioned cup body 10 and the sample bottle 30 enables the first cavity 11 in the cup body 10 to be always communicated with the second cavity 31 in the sample 30, that is, the sample in the first cavity 11 is always communicated with the sample in the second cavity 31. If the operator places a test element or adds some detection reagents in the first cavity 11, it will inevitably affect the sample in the second cavity 31 and contaminate the sample reserved in the second cavity 31, making the sample retention function of the sample bottle 30 meaningless. Therefore, a sealing element needs to be provided between the cup body 10 and the sample bottle 30 to control the communication relationship between the first cavity 11 and the second cavity 31. When retaining the sample, the first cavity 11 is communicated with the second cavity 31. When detecting, the first cavity 11 is separated from the second cavity 31.

[0074] Specifically, referring to the attached Figure 4 attachment Figure 6 , the technical solution adopted by the present invention is as follows: A groove 35 is provided on the bottle mouth 33. The groove 35 is located at the position of the screw thread 34. A first column 51 is provided on the sealing element 50. The sealing element 50 can be snapped into the groove 35 through the first column 51 to realize the detachable connection between the sealing element 50 and the sample bottle 30, that is, the second cavity 31 and the sealing element 50 are in detachable connection. To ensure the stability of the sealing element 50 fixed on the sample bottle 30, at least two grooves 35 are provided at the position of the bottle mouth 33 of the sample bottle 30. Correspondingly, at least two first columns 51 are also provided. Generally, the number of grooves 35 is the same as the number of first columns 51. The two first columns 51 are symmetrically arranged at the center on the sealing element 50. When the sealing element 50 is fixed on the sample bottle 30, the sealing element 50 will rotate with the rotation of the sample bottle 30. If the sample bottle 30 is fixed on the bottom tray 40, the sample bottle 30 will rotate with the rotation of the bottom tray 40. At this time, a relative rotation occurs between the sample bottle 30 and the cup body 10, and a relative rotation occurs between the second cavity 31 and the first cavity 11.

[0075] The first chamber 11 communicates with the second chamber 31 through the first hole 13. Therefore, the installation position of the sealing element 50 is located at the position of the first hole 13, and a second hole 52 is provided on the sealing element 50. During the sample retention process, the second hole 52 communicates with the first hole 13, and the first chamber 11 communicates with the second chamber 31. During detection, if necessary, by adjusting the sealing element 50, the second hole 52 is made non-communicating with the first hole 13. Correspondingly, the first chamber 11 and the second chamber 31 are non-communicating (isolated). The simplest way to adjust the sealing element 50 here is to switch the state by rotating the sealing element 50. Since the above structure (the bottom tray 40, the sample bottle 30) can already achieve the rotation of the sealing element 50, the rotation switching mode is selected, and there is no need to additionally introduce new components, which helps to reduce the overall production cost of the detection device.

[0076] Due to the use of the rotation switching state mode, the first hole 13 cannot be located at the center position of the upper inner wall of the third chamber 12, and the second hole 52 cannot be located at the center position of the upper end face of the sealing element 50. Because if both of them are located at the center position, when the sealing element 50 rotates, the switching between the communication and non-communication of the first hole 13 and the second hole 52 cannot be achieved. Therefore, both the first hole 13 and the second hole 52 should be eccentrically arranged. Refer to the appendix Figures 6-12 , when the sealing element 50 rotates, the first hole 13 and the second hole 52 are in a state of switching between communication and non-communication. When the first hole 13 communicates with the second hole 52, the first chamber 11 communicates with the second chamber 31. When the first hole 13 does not communicate with the second hole 52, the first chamber 11 and the second chamber 31 are non-communicating. In order to increase the communication volume between the first chamber 11 and the second chamber 31 when they communicate, two first holes 13 are provided on the cup body 10, and two second holes 52 are also provided on the sealing element 50. Such a design makes it easier for the sample to flow from the first chamber 11 to the second chamber 31 when the first chamber 11 communicates with the second chamber 31.

[0077] Since the sealing element 50 is located at the junction of the cup body 10 and the sample bottle 30, a part of the sealing element 50 contacts the cup body 10, and a part of the sealing element 50 contacts the sample bottle 30. The sealing element 50 serves to connect the first chamber 11 and the second chamber 31 and transport the sample. In order to enable the sample in the retained sample part to enter the second chamber 31 from the first chamber 11 as completely as possible, it is necessary to solve the problem of sample leakage from the contact gaps between the cup body 10, the sealing element 50, and the sample bottle 30 during the design. Preferably, the part of the sealing element 50 that contacts the sample bottle 30 extends into the bottle mouth 33, and the lower side of the sealing element 50 is an arc surface, which can prevent the sample from leaking from the bottle mouth 33. At the same time, the contact part of the sealing element 50 and the cup body 10 is the upper wall of the third chamber 12. In the mass production of the detection device, for the convenience of processing the cup body 10, the upper wall of the third chamber 12 of the cup body is generally a plane, and correspondingly, the upper side of the sealing element 50 is also a plane. It is easy to leak between the two flat surfaces. Preferably, the side of the sealing element 50 that contacts the cup body 10 is made of a soft material, such as silica gel, which can prevent the sample from leaking at the contact position between the sealing element 50 and the upper wall of the third chamber 12. The lower part of the sealing element 50 that contacts the sample bottle 30 is made of a hard material, and generally a soft material is not selected. This is because the first column 51 is provided on the sealing element 50. The first column 51 is connected to the sealing element 50, and the material of the connected part is generally the same. The first column 51 must be made of a hard material (rigid). In this way, during the rotation of the sample bottle 30, the sealing element 50 will not fall off from the groove 35. If the first column 51 is made of a soft material, then due to the friction between the sealing element 50 and the upper wall of the third chamber 12, it is very likely that when the sample bottle 30 rotates, the first column 51 will slide off from the groove 35, resulting in the situation where the sample bottle 30 rotates and the sealing element 50 does not rotate. Since the first column 51 is made of a hard material and the upper part of the sealing element 50 is made of a soft material, the first column 51 can only be connected to the lower part of the sealing element 50. Also, because the material of the connected part is generally the same, the side of the sealing element 50 that contacts the sample bottle 30 is made of a hard material. Of course, if the manufacturing cost of the sealing element 50 is not considered, on the premise of ensuring that the first column 51 is made of a hard material, it is also possible to select that the parts of the sealing element 50 that contact the cup body 10 and the sample bottle 30 are both made of soft materials. First, the shape of the first column 51 is manufactured in production, and then the first column 51 is placed in a mold to process the remaining soft material part. This method has a high manufacturing cost and is very cumbersome, and is not preferred. By using the sealing element 50 provided by the present invention, after the hard part is processed, the soft material part can be directly pasted on its upper surface to complete, with a fast processing speed and a low manufacturing cost.

[0078] The above sample bottle 30 can be disassembled and is independent of the device. In order to ensure that the first cavity 11 in the cup body 10 can still store the sample after the sample bottle 30 is disassembled, and the sample will not leak due to the separation of the sealing element 50 after the sample bottle 30 is removed. To achieve this goal, the sealing element 50 and the cup body 10 are detachably connected, that is, the sealing element 50 and the first cavity 11 are detachably connected. When the detection device is assembled, the sealing element 50 is separated from the cup body 10; after the sample bottle 30 stores and takes out the sample, the sealing element 30 is assembled with the cup body 10 to seal the first hole 13. The technical solution adopted by the present invention is that there is a notch 17 on the top of the third cavity 12 of the cup body 10, and there is a second post 53 on the sealing element 50. The second post 53 is perpendicular to the first post 51. By rotating the bottom tray 40 to drive the sealing element 50 to rotate, the second post 53 can be caught in the notch 17. Specifically, corresponding to the first post 51, there are also two second posts 53, and the two second posts 53 are collinear. At the same time, there are also two notches 17, and the two notches 17 are arranged in a centrally symmetric form with the first hole 13 as the center. In this way, the sealing element 50 is more stable when the second post 53 is caught in the notch 17. The notch 17 includes a limiting portion 18 and a supporting portion 19. The limiting portion 18 is used to limit the rotation of the sealing element 50. When the second post 53 collides with the limiting portion 18, the sealing element 50 cannot continue to rotate. At this time, the supporting portion 19 plays a supporting role and can keep the sealing element 50 in the notch 17, that is, the sealing element 50 remains in the third cavity 12. Preferably, in order for the limiting portion 18 to play a better limiting role and a better role in connecting the supporting portion 19 and the cup body 10, the limiting portion 18 is in an "L" shape, and the two notches 17 on the top of the third cavity 12 are arranged in a centrally symmetric form. In this case, although the sealing element 50 has two rotation directions, only one direction can be caught in the notch 17. Specifically, refer to the appendix Figure 7 : When the sealing element 50 rotates in one direction, the second post 53 can be caught in the notch 17. At this time, the second post 53 abuts against the notch 17, and the sealing element 50 cannot continue to rotate in this direction; when the sealing element 50 rotates in the other direction, the second post 53 cannot be caught in the notch 17.

[0079] Preferably, when the second post 53 is rotated and snapped into the notch 17, the clamping point 43 on the base 40 is located within the horizontal section 15. At this time, the sealing element 50 has been fixed to the cup body 10. In order to be able to remove the sample bottle 30 at this time, the fixation at least further includes a vertical section 16. The clamping point 43 on the base 40 can be removed from the cup body 10 along this vertical section 16. At the same time, the first post 51 of the sealing element 50 slides out along the groove 35 on the mouth 33 of the sample bottle 30. The operator then removes the sample bottle 30 from the fixing buckle 41 of the base 40 and reinstalls the base 40 onto the cup body 10, thus completing the operation of removing the sample bottle 30 on the premise of sealing the first cavity 11. In summary, a fixing groove 14 at least includes a horizontal section 15 and two vertical sections 16. To facilitate the control of the rotation of the base 40 and the sealing element 50, the vertical sections 16 are connected to both ends of the horizontal section 15. Such a design can prevent the second rod 53 on the sealing element 50 from colliding with the notch 17 due to excessive movement of the base 40, resulting in breakage. When the sealing element 50 is rotated from the initial position into the notch 17, the clamping point 43 also exactly moves from one end of the horizontal section 15 to the other end. In addition, when the base 40 enters the horizontal section 15 from a vertical section 16, the base 40 has only one rotatable direction, which facilitates the operation of the operator and eliminates the need to distinguish the sealing direction (rotation direction) of the sealing element 50.

[0080] Preferably, referring to the attached Figure 5 , attached Figure 6 , the arc angle formed by the two vertical sections 16 on the cup body 10 is ninety degrees, that is, the radian angle of the horizontal section 15 is ninety degrees, which also means that the sealing element 50 can be rotated ninety degrees. Ninety degrees exactly meets the switching between the communication and non-communication of the first hole 13 and the second hole 52. At the same time, at ninety degrees, the range that the sealing element 50 can rotate is relatively large. Correspondingly, a relatively large space is left for opening the first hole 13 and the second hole 52, which is beneficial to improving the efficiency of the sample in the first cavity 11 entering the second cavity 31.

[0081] The following provides a supporting usage method in combination with the detection device provided by the present invention. First, assemble the detection device. Referring to the attached Figure 4 , attached Figure 5 , install the sample bottle 30 onto the base 40 through the fixing buckle 41. Subsequently, insert the first post 51 of the sealing element 50 along the groove 35 on the sample bottle 30 onto the sample bottle 30. Referring to the attached Figure 6, align the clamping points 43 on the bottom tray 40 with a pair of vertical sections 16 on the cup body 10, install the bottom tray 40 on the cup body 10 and move it along the vertical sections 16 to the bottom. It should be noted that although there are two pairs of vertical sections 16 on the cup body 10, the bottom tray 40 cannot be installed along both pairs. When the clamping points 43 are installed along a pair of vertical sections 16, the second post 53 on the sealing element 50 will collide with the support part 17 of the notch 19, resulting in the bottom tray 40 being unable to move to the bottom along the vertical sections 16. Therefore, the operator needs to distinguish the vertical sections 16. After the bottom tray 40 moves to the bottom along the vertical sections 16, refer to the appendix Figures 6-8 , at this time, the first hole 13 communicates with the second hole 52, and this state is also the initial state of the sealing element 50 in the above content. Refer to the appendix Figure 9 、appendix Figure 10 , the operator rotates the bottom tray 40 (it is stipulated as a forward rotation at this time), the clamping points 43 move along the horizontal section 15, and at the same time, the bottom tray 40 drives the sealing element 50 to rotate through the sample bottle 30, and the communication size between the first hole 13 and the second hole 52 gradually decreases. Refer to 11, appendix Figure 12 , when the clamping points 43 move to the end of the horizontal section 15, the second post 53 on the sealing element 50 is completely stuck into the notch 19. At this time, the first hole 13 and the second hole 52 are not in communication, and the sealing element 50 realizes the switching of the first cavity 11 and the second cavity 31 from communication to non-communication. The operator then screws on the cup lid 20 until the first retaining buckle 21 abuts against the second retaining buckle 22, that is, the assembly of the detection device is completed.

[0082] Refer to the appendix Figure 1 、appendix Figure 3 , unscrew the cup lid 20, add a sample into the first cavity 11, and close the cup lid 20, that is, the sampling operation is completed. Rotate the bottom tray 40 in the reverse direction (that is, perform the above forward rotation operation of the bottom tray 40 in reverse), the first hole 13 and the second hole 52 change from the non-communication state to the communication state, and the sample in the first cavity 11 enters the second cavity 31 of the sample bottle 30 through the communication area between the first hole 13 and the second hole 52 under the action of gravity. It should be noted that at this time, do not rotate the clamping points 43 to the end of the horizontal section 15, because the end of the horizontal section 15 is connected to the vertical section 16. If the clamping points 43 move to the end of the horizontal section 15 at this time, then it is very likely that without the operator holding the bottom tray 40, the bottom tray 40 will drive the sample bottle 30 and the sealing element 50 to fall, resulting in the sample spilling. Therefore, it is preferably not to continue rotating when rotating in the reverse direction until reaching the middle section of the horizontal section 15, as shown in appendix Figure 9 、appendix Figure 10At this state, the horizontal section 15 can support the stuck point 43, and the bottom support 40, the sample bottle 30, and the sealing element 50 will not separate from the cup body 10. Wait for a period of time, generally 30 seconds is sufficient. By this time, enough samples have entered the second cavity 31 through the communication area between the first hole 13 and the second hole 52. The operator twists the bottom support 40 to continue rotating forward. At this time, the first hole 13 and the second hole 52 change from the communication state to the non-communication state again until the stuck point 43 moves to the end of the horizontal section 15, and the second post 53 on the sealing element 50 is stuck into the notch 19 again. At this time, the first hole 13 is completely sealed by the sealing element 50. Refer to the appendix Figure 13 , pull out the bottom support 40 along the vertical section 16. During this process, since the second post 53 of the sealing element 50 is still stuck in the notch 17, the sealing element 50 remains fixed on the cup body 10, and the fixing buckle 41 on the bottom support 40 is still in the state of fixing the sample bottle 30. The sample bottle 30 and the bottom support 40 leave the cup body 10 together. At the same time, the first post 51 of the sealing element 50 disengages from the groove 35 of the sample bottle 30. The operator reaches into the empty slot 27 with a finger to take out the bottle cap 26 in the installation slot 24, then screw the bottle cap 26 and the screw thread 34 of the bottle mouth 33 together to complete the sealing of the sample bottle 30, take out the sample bottle 30 from the bottom support 40, make it independent of the device, and then fix the bottom support 40 back onto the cup body 10, thus completing the reservation and extraction of the sample.

Claims

1. A detection device, characterized in that, It includes a first chamber located inside the cup body for collecting liquid samples; a second chamber located inside the sample bottle; a first hole for connecting the second chamber and the first chamber; and a rotatable sealing element; the connection state and non-connection state between the first chamber and the second chamber are achieved by the rotation of the sealing element. The sealing element is provided with a second hole. When the sealing element rotates, the switching between the connection state and non-connection state of the first hole and the second hole occurs. When the first hole and the second hole are connected, the first chamber and the second chamber are connected. When the first hole and the second hole are not connected, the first chamber and the second chamber are not connected. The sample bottle is detachable. When the sample bottle is removed, the first chamber and the second chamber are separated. The sample bottle and the sealing element are detachably connected, so that the second chamber and the sealing element are detachably connected. The sealing element and the cup body are detachably connected, so that the sealing element and the first chamber are detachably connected. The sample bottle can rotate relative to the cup body, and the rotation of the sample bottle drives the rotation of the sealing element. The sample bottle includes a bottle mouth, a groove is provided on the bottle mouth, and a first post is provided on the sealing element, and the first post can be inserted into the groove. A notch is provided on the cup body, and a second post is provided on the sealing element. By rotating the sealing element, the second post can be inserted into the notch. The detection device further includes a bottom tray, the bottom tray and the cup body are detachably connected. When the bottom tray is installed on the cup body, the bottom tray can rotate, thereby driving the rotation of the sample bottle.

2. The detection device according to claim 1, characterized in that, A helix is provided at the position of the bottle mouth of the sample bottle, and the groove is located at the helix position.

3. The detection device according to claim 2, characterized in that, At least two grooves are provided at the position of the bottle mouth of the sample bottle. Correspondingly, at least two first posts are provided.

4. The detection device according to claim 1, characterized in that, The sealing element has two rotation directions. When the sealing element rotates in one direction, the second post can be inserted into the notch. When the sealing element rotates in the other direction, the second post cannot be inserted into the notch.

5. The detection device according to claim 4, characterized in that, After the second post rotates in one direction and is inserted into the notch, the second post abuts against the notch, and the sealing element cannot continue to rotate in this direction.

6. The detection device according to claim 1, characterized in that, The first post is perpendicular to the second post.

7. The detection device according to claim 1, characterized in that, The sealing element is located at the junction position between the cup body and the sample bottle. A part of the sealing element is in contact with the cup body, and a part of the sealing element is in contact with the sample bottle. The side of the sealing element in contact with the cup body is made of a soft material, and the side of the sealing element in contact with the sample bottle is made of a hard material.

8. The detection device according to claim 1, characterized in that, A clamping point is provided on the bottom tray, and a fixing groove is provided on the cup body, and the clamping point can move along the fixing groove.

9. The detection device according to claim 8, characterized in that, The fixing groove is divided into a vertical section and a horizontal section. One fixing groove includes at least one horizontal section and two vertical sections.

10. A detection device according to claim 9, characterized in that, The vertical sections connect the two ends of the horizontal section, and the arc angle formed by the two vertical sections on the cup body is ninety degrees.

11. A detection device according to claim 8, characterized in that, Two fixing grooves are provided on the cup body in a centrosymmetric manner.

12. The detection device according to claim 1, characterized in that, The bottom tray and the sample bottle are detachably connected. The sample bottle can rotate with the rotation of the bottom tray, and the sealing element can rotate with the rotation of the bottom tray.

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