Chemiluminescence Immunoassay Analyzer

Abstract

The present invention discloses a chemiluminescent immunoassay analyzer, which includes a frame and a pipetting arm module, a reagent refrigeration module, a sample and TIP supply module, an incubation reaction module, and a waste bin module provided on the frame; the pipetting arm module has degrees of freedom in the X direction and the Z direction; the reagent refrigeration module is rotatably provided on the frame for refrigerating reagents; the sample and TIP supply module can move in the Y direction on the frame for providing disposable pipette tips, samples to be tested, and reagents. The present invention integrates functions such as pipetting, reagent refrigeration, sample and TIP supply, incubation reaction, and waste collection, which can greatly improve the efficiency and convenience of chemical analysis and has good practical application value. By providing a sliding cover mechanism, the present invention can achieve the addition of samples without opening the box cover, thereby reducing the interference with the internal environment of the incubation box when the box cover is opened.

Description

Technical Field

[0001] The present invention relates to the field of immunoassay, and particularly to a chemiluminescence immunoassay analyzer. Background Art

[0002] Immunological detection is mainly a means of detection using the specific reaction between antigens and antibodies. Since it can amplify and display detection signals using isotopes, enzymes, chemiluminescent substances, etc., it is often used for detecting trace substances such as proteins and hormones. Since the 1960s, immunoassay has been widely applied in the scientific research and clinical fields. It has gradually developed from the initial radioimmunoassay to enzyme-linked immunosorbent assay, and until the currently widely used chemiluminescence immunoassay.

[0003] Chemiluminescence immunoassay is a new type of labeled immunoassay technology that combines chemiluminescence or bioluminescence with immunoassay for detecting trace antigens or antibodies. The mechanism of chemiluminescence is that certain compounds (luminescent agents or luminescent substrates) can use the energy generated by a chemical reaction to raise the product molecules or reaction intermediate molecules to the electronically excited state. When these product molecules or intermediate molecules decay to the ground state, they release energy in the form of emitted photons (i.e., luminescence). Immunoassay is a method for measuring trace substances in specimens using antigen-antibody reactions. Chemiluminescence immunoassay equipment is widely used, but current chemiluminescence immunoassay equipment has some deficiencies, such as low inspection efficiency, low automation level, inconvenient operation, etc. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to provide a chemiluminescence immunoassay analyzer in view of the deficiencies in the above-mentioned prior art.

[0005] To solve the above technical problem, the technical solution adopted by the present invention is: a chemiluminescence immunoassay analyzer, including a frame and a pipetting arm module, a reagent refrigeration module, a sample and TIP supply module, a incubation reaction module, and a waste bin module provided on the frame;

[0006] Among them, the pipetting arm module has degrees of freedom in the X direction and the Z direction; the reagent refrigeration module is rotatably provided on the frame for refrigerating reagents; the sample and TIP supply module can move in the Y direction on the frame for providing disposable pipette tips, samples to be tested, and reagents; the incubation reaction module is used for performing incubation reactions, and is provided with an electric lid-opening mechanism thereon.

[0007] Preferably, the electric lid-opening mechanism includes a box body cover plate disposed on the incubation box of the incubation reaction module, a support seat disposed on the side wall of the incubation box, a rotating shaft pivotally connected to the support seat, a worm gear fixedly connected to the rotating shaft, an L-shaped connecting rod with a first end fixedly connected to the rotating shaft and a second end fixedly connected to the box body cover plate, a first motor disposed on the frame, and a worm gear for cooperatively driving the rotation of the worm gear and drivingly connected to the output shaft of the first motor;

[0008] A baffle is disposed at the end of the rotating shaft, and a photoelectric switch cooperating with the baffle is disposed on the rotating shaft;

[0009] A microfluidic disk is disposed in the incubation reaction module, and the microfluidic disk has an injection port, a reaction tank, and a detection chamber.

[0010] Preferably, a sliding cover mechanism is disposed on the box body cover plate. The sliding cover mechanism includes a sliding base disposed on the box body cover plate, a sampling window opened on the sliding base and communicating with the inside of the incubation box, a sliding block slidably disposed at the bottom of the sliding base, and a driving mechanism for driving the sliding block to slide back and forth horizontally in the sliding base.

[0011] Preferably, the driving mechanism includes a second motor disposed on the sliding base, a rotating wheel drivingly connected to the output shaft of the second motor, and a rotating handle connected to the bottom of the rotating wheel;

[0012] A longitudinal chute perpendicular to the sliding direction of the sliding block is opened on the sliding block, and the rotating handle is cooperatively inserted into the chute to drive the sliding block to perform a horizontal linear motion.

[0013] Preferably, a first inductive optocoupler and a second inductive optocoupler are further disposed at the bottom of the sliding base, and the first inductive optocoupler and the second inductive optocoupler are in the same straight line longitudinally;

[0014] A sampling notch for cooperating with the sampling window, a first optocoupler hole for cooperating with the first inductive optocoupler, and a second optocoupler hole for cooperating with the second inductive optocoupler are further opened on the sliding block. The first optocoupler hole and the second optocoupler hole are not in the same straight line longitudinally and horizontally.

[0015] Preferably, the sample and TIP supply module includes a bottom plate slidably disposed on the frame, a disposable pipette tip holder, a sample rack, and a reagent storage device disposed on the bottom plate. A first barcode scanner is further disposed on the sample and TIP supply module.

[0016] Preferably, the pipetting arm module includes a pipetting arm bracket, an X-axis module that can move along the X direction on the pipetting arm bracket, a Z-axis module that can move along the Z direction on the X-axis module, and a pipette disposed on the Z-axis module.

[0017] Preferably, the X-axis module includes an X-axis guide rail disposed on the pipetting arm bracket, an X-axis slider slidably disposed on the X-axis guide rail, and an X-axis motor for driving the movement of the X-axis slider.

[0018] Preferably, the Z-axis module includes a mounting bracket connected to the X-axis slider, a Z-axis guide rail disposed on the mounting bracket, an upper slider and a lower slider slidably disposed on the Z-axis guide rail from top to bottom in sequence, a lead screw disposed on the mounting bracket, and a Z-axis motor for driving the rotation of the lead screw;

[0019] A threaded hole matching the lead screw is formed through the upper slider, and a through hole for the lead screw to pass through is formed through the lower slider; the lower end of the lead screw passes through the threaded hole and the through hole in sequence;

[0020] A spring is connected between the upper slider and the lower slider, and the pipette is disposed on the lower slider.

[0021] Preferably, it further includes a GPRS communication module, which is used to connect the chemiluminescence immunoassay analyzer to the Internet of Things, realize the functions of real-time monitoring of the instrument status, maintenance reminder, and maintenance alarm, and can notify the maintenance engineer and the operation management center in time for processing

[0022] The beneficial effects of the present invention are as follows: The chemiluminescence immunoassay analyzer of the present invention integrates functions such as pipetting, reagent refrigeration, sample and TIP supply, incubation reaction, and waste collection, which can greatly improve the efficiency and convenience of chemical analysis and has good practical use value. The pipette of the present invention can realize the electric control of the movement in the X direction and the Z direction, and realizes the flexible contact between the pipette and the pipetting object by setting a spring, which can ensure the smooth progress of pipetting and can protect the pipette and the pipetting object; the present invention can complete the addition of samples without opening the box cover by setting a sliding cover mechanism, thereby reducing the interference to the internal environment of the incubation box when the box cover is opened. The structure of the present invention is simple, the degree of automation is high, and it is easy to use, and has broad application prospects. Description of the Drawings

[0023] Figure 1 It is a schematic structural diagram of the chemiluminescence immunoassay analyzer of the present invention;

[0024] Figure 2 It is a schematic structural diagram of another perspective of the chemiluminescence immunoassay analyzer of the present invention;

[0025] Figure 3Structural schematic diagram of the Z-axis module of the present invention;

[0026] Figure 4 Structural schematic diagram of the incubation reaction module of the present invention;

[0027] Figure 5 Structural schematic diagram of the sliding cover mechanism of the present invention;

[0028] Figure 6 Structural schematic diagram of the sliding base of the present invention viewed from the bottom;

[0029] Figure 7 Structural schematic diagram of the sliding block of the present invention;

[0030] Figure 8 Structural schematic diagram of the sliding cover mechanism of the present invention when it is fully closed;

[0031] Figure 9 Structural schematic diagram of the sliding cover mechanism of the present invention when it is fully opened;

[0032] Figure 10 Structural schematic diagram of the microfluidic disk in the incubation reaction module of the present invention;

[0033] Figure 11 Schematic diagram of the working principle of connecting the chemiluminescence immunoassay analyzer of the present invention to the Internet of Things in an embodiment.

[0034] Explanation of reference numerals:

[0035] 1 - Frame; 2 - Pipetting arm module; 3 - Reagent refrigeration module; 4 - Sample and TIP supply module; 5 - Incubation reaction module; 6 - Waste bin module; 7 - Sliding cover mechanism; 20 - Pipetting arm bracket; 21 - X-axis module; 22 - Z-axis module; 23 - Pipetting gun; 30 - Small hole; 31 - Second barcode scanner; 32 - Scanning window; 40 - Bottom plate; 41 - Disposable pipette tip holder; 42 - Sample rack; 43 - Reagent storage device; 44 - First barcode scanner; 50 - Incubation box; 51 - Box cover; 52 - Support seat; 53 - Rotating shaft; 54 - Worm gear; 55 - L-shaped connecting rod; 56 - First motor; 57 - Worm; 58 - Baffle; 59 - Photoelectric switch; 70 - Sliding base; 71 - Sampling window; 72 - Sliding block; 73 - Second motor; 74 - Runner; 75 - Turning handle; 210 - X-axis guide rail; 211 - X-axis slider; 212 - X-axis motor; 220 - Mounting frame; 221 - Z-axis guide rail; 222 - Upper slider; 223 - Lower slider; 224 - Lead screw; 225 - Z-axis motor; 500 - Microfluidic disk; 700 - First inductive optocoupler; 701 - Second inductive optocoupler; 720 - Longitudinal chute; 721 - Sampling notch; 722 - First optocoupler hole; 723 - Second optocoupler hole. Detailed implementation manners

[0036] The present invention will be further described in detail below in conjunction with embodiments, so that those skilled in the art can implement it with reference to the text of the specification.

[0037] It should be understood that terms such as "having", "comprising", and "including" used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

[0038] As Figures 1-10 shown, a chemiluminescence immunoassay analyzer according to this embodiment includes a frame 1 and a pipetting arm module 2, a reagent refrigeration module 3, a sample and TIP supply module 4, an incubation reaction module 5, and a waste bin module 6 provided on the frame 1;

[0039] Among them, the pipetting arm module 2 has degrees of freedom in the X direction and the Z direction; the reagent refrigeration module 3 is rotatably provided on the frame 1 for refrigerating reagents; the sample and TIP supply module 4 can move in the Y direction on the frame 1 for providing disposable pipette tips, samples to be tested, and reagents; the incubation reaction module 5 is used for performing incubation reactions, and is provided with an electric lid-opening mechanism thereon. The pipette 23 on the pipetting arm module 2 can move in the X direction and the Z direction to aspirate disposable pipette tips, samples to be tested, reagents on the sample and TIP supply module 4, refrigerated reagents in the reagent refrigeration module 3, and add samples to the incubation reaction module 5 for reaction. The direction description in the present invention refers to Figure 1 the coordinate system in

[0040] The reagent refrigeration module 3 is used for refrigerating reagents. In this embodiment, it has a refrigeration function of 2-8°C and provides a rotational movement (realized by a conventional motor rotation mechanism), and cooperates with the pipetting arm module 2 to complete the sampling work of multiple reagents. Small holes 30 are opened on the lid of the reagent refrigeration module 3. The reagent is refrigerated inside, and pipetting can be completed without opening the lid. In cooperation with the rotation of the reagent refrigeration module 3, the pipette 23 on the pipetting arm module 2 extends into the small holes 30 to aspirate the reagents inside the reagent refrigeration module 3. In a preferred embodiment, the module is further equipped with a second barcode scanner 31, and a scanning window 32 is provided on the side of the reagent refrigeration module 3. The reagent kits inside the reagent refrigeration module 3 are scanned by the second barcode scanner 31.

[0041] The incubation reaction module 5 has functions such as incubation, rotation, centrifugation, and measurement, and is the reaction position of the entire instrument.

[0042] In one embodiment, a microfluidic disk 500 is provided inside the incubation reaction module 5 (such as Figure 10) motors, heating elements (not shown in the figure), etc. The microfluidic disk has an injection port, reaction tanks, and detection chambers. The motor is used to drive the rotation of the microfluidic disk, and the heating element is used to heat the microfluidic disk; the sample and reagent are mixed and reacted in the microfluidic disk, and the reaction result is obtained through a detector. Thus, the sample is analyzed to obtain the detection and analysis result.

[0043] The waste bin module 6 is responsible for collecting waste pipette tips, waste liquid, etc., and can use disposable garbage bags for collection. In addition, for customers with large usage, a chute-type waste bin can be optionally configured to directly slide the waste through the chute into an external trash can.

[0044] In one embodiment, the overall working process of the chemiluminescence immunoassay analyzer of the present invention is as follows: The pipette 23 on the pipetting arm module 2 moves to the sample and TIP supply module 4, sucks a disposable pipette tip, and then moves to the reagent refrigeration module 3, sucks the refrigerated reagent therein and injects it into the microfluidic disk in the incubation reaction module 5; then replace the disposable pipette tip (the disposable pipette tip needs to be replaced when sucking different reagents) and inject the reagent in the reagent storage device 43 and the sample on the sample rack 42 into the microfluidic disk in the incubation reaction module 5 for reaction and detection respectively to complete the chemical analysis. When the sample needs to be diluted, the sample is first injected into the reagent tube containing the diluent on the sample rack 42 for dilution, and then injected into the microfluidic disk in the incubation reaction module 5.

[0045] Suck the reagent in the reagent storage device 43 on the pipetting arm module 2 and inject it into the sample reagent tube on the sample rack 42, and then suck other reagents after replacing the disposable pipette tip; when sucking the refrigerated reagent in the reagent refrigeration module 3, first rotate the reagent refrigeration module 3 to rotate the reagent to be sucked under the small hole 30, and then move the pipette 23 to extend into the small hole 30 to transfer the corresponding refrigerated reagent into the sample reagent tube; after the liquid addition is completed, suck the sample mixed with the reagent and inject it into the incubation reaction module 5 for reaction and detection to complete the chemical analysis.

[0046] In one embodiment, referring to Figure 4 , the electric opening mechanism includes a box body cover plate 51 provided on the incubation box 50 of the incubation reaction module 5, a support seat 52 provided on the side wall of the incubation box 50, a rotating shaft 53 pivotally connected to the support seat 52, a worm gear 54 fixedly connected to the rotating shaft 53, an L-shaped connecting rod 55 with the first end fixedly connected to the rotating shaft 53 and the second end fixedly connected to the box body cover plate 51, a first motor 56 provided on the frame 1, and a worm 57 drivingly connected to the output shaft of the first motor 56 for cooperatively driving the rotation of the worm gear 54; a baffle 58 is provided at the end of the rotating shaft 53, and a photoelectric switch 59 cooperating with the baffle 58 is provided on the rotating shaft 53.

[0047] The motor rotates, drives the worm wheel 54 to rotate through the worm 57, and then drives the L-shaped connecting rod 55 to rotate through the rotating shaft 53, thereby opening or closing the box cover 51. The photoelectric switch 59 cooperates with the baffle 58 to detect the opening and closing of the box cover 51. The box cover 51 can be electrically opened, which is convenient for replacing components inside the incubation box 50, such as discs.

[0048] In a further preferred embodiment, referring to Figures 5-9 , a sliding cover mechanism 7 is provided on the box cover 51. The sliding cover mechanism 7 includes a sliding base 70 provided on the box cover 51, a sampling window 71 opened on the sliding base 70 and communicating with the inside of the incubation box 50, a sliding block 72 slidably provided at the bottom of the sliding base 70, and a driving mechanism for driving the sliding block 72 to slide back and forth horizontally within the sliding base 70. The driving mechanism includes a second motor 73 provided on the sliding base 70, a runner 74 drivingly connected to the output shaft of the second motor 73, and a turning handle 75 connected to the bottom of the runner 74; a longitudinal chute 720 perpendicular to its sliding direction is opened on the sliding block 72, and the turning handle 75 is fitted and inserted into the chute to drive the sliding block 72 to perform a horizontal linear motion.

[0049] Wherein, a first inductive optocoupler 700 and a second inductive optocoupler 701 are further provided at the bottom of the sliding base 70, and the first inductive optocoupler 700 and the second inductive optocoupler 701 are in the same straight line longitudinally;

[0050] A sampling notch 721 for cooperating with the sampling window 71, a first optocoupler hole 722 for cooperating with the first inductive optocoupler 700, and a second optocoupler hole 723 for cooperating with the second inductive optocoupler 701 are further opened on the sliding block 72. The first optocoupler hole 722 and the second optocoupler hole 723 are not in the same straight line longitudinally and horizontally.

[0051] In this embodiment, the sliding cover mechanism 7 is used to complete the addition of samples without opening the box cover 51, so as to reduce the interference to the internal environment of the incubation box 50 when the box cover 51 is opened. The specific principle is as follows: The second motor 73 drives the runner 74 to rotate. The turning handle 75 at the bottom of the runner 74 is stuck in the longitudinal chute 720 of the sliding block 72 and is restricted to slide only along the longitudinal chute 720. The sliding block 72 is further restricted by the sliding base 70 to slide only horizontally; when the runner 74 rotates, the turning handle 75 moves under the restriction of the longitudinal chute 720, thereby driving the sliding block 72 to slide horizontally within the sliding base 70. When the sampling notch 721 on the sliding block 72 aligns with the sampling window 71 on the sliding base 70, the sliding cover mechanism 7 is in an open state, and the sample can be added into the incubation box 50 through the pipette 23; when the sampling notch 721 is blocked by other parts of the sliding base 70, the sliding cover mechanism 7 is in a closed state.

[0052] The sample loading notch 721 is the same size and shape as the sample loading window 71. In a preferred embodiment, when the sliding cover mechanism 7 is opened, it needs to be fully opened, that is, the sample loading notch 721 is completely aligned with the sample loading window 71. If the sample loading notch 721 and the sample loading window 71 are partially aligned, such as only half opened, the disposable pipette tip on the pipette 23 is easily blocked by the sliding block 72 when it extends through the sample loading window 71 for sample loading. And when the sliding cover mechanism 7 is closed, it needs to be fully closed, that is, the sample loading window 71 should be completely blocked to maintain sealing, ensure heat preservation inside the incubation box 50 and isolation from the external environment. In this embodiment, the above functions are achieved through the cooperation of the first inductive optocoupler 700, the second inductive optocoupler 701 with the first optocoupler hole 722 and the second optocoupler hole 723. The specific principle is as follows: Refer to Figure 9 , when the sliding cover mechanism 7 is fully opened, the sample loading notch 721 is aligned with the sample loading window 71. At this time, the first inductive optocoupler 700 is directly opposite to the first optocoupler hole 722, generating a trigger signal, which can be assumed as "on", and the second inductive optocoupler 701 is completely blocked, generating a trigger signal, which can be assumed as "off"; that is, when the signal of the first inductive optocoupler 700 is "on" and the signal of the second inductive optocoupler 701 is "off", it is determined that the sliding cover mechanism 7 is fully opened. When the pipette 23 is used for sample loading, the full opening of the sliding cover mechanism 7 ensures smooth sample loading through the sample loading window 71; after the sample loading is completed, the sliding cover mechanism 7 is fully closed to seal the sample loading window 71, achieving the effects of heat preservation and isolation.

[0053] Among them, when the sliding cover mechanism 7 is fully closed, refer to Figure 8, the second inductive optocoupler 701 is aligned with the second optocoupler hole 723 to generate a trigger signal, which can be assumed as "on", and the first inductive optocoupler 700 is completely blocked to generate a trigger signal, which can be assumed as "off"; that is, when the signal of the first inductive optocoupler 700 is "off" and the signal of the second inductive optocoupler 701 is "on", it is determined that the sliding cover mechanism 7 is fully opened. Using this structure can overcome the defect of misjudgment caused by using a single inductive optocoupler and optocoupler hole combination. For example, if only the first inductive optocoupler 700 and the first optocoupler hole 722 are used, when half of the sample addition notch 721 is aligned with the sample addition window 71, half of the first inductive optocoupler 700 is at the first optocoupler hole 722, and the first inductive optocoupler 700 becomes partially unblocked (from being completely blocked to partially unblocked), and part of the signal emitted by the first inductive optocoupler 700 will also pass through the first optocoupler hole 722, thereby generating a trigger signal and misjudging that the sample addition notch 721 is completely aligned with the sample addition window 71. The principle of judging when the sliding cover mechanism 7 is closed is the same, that is, when the sliding block 72 partially covers the sample addition window 71, the first inductive optocoupler 700 is also partially covered (from being completely uncovered to partially covered), and the first inductive optocoupler 700 will generate a trigger signal, misjudging that the sample addition window 71 is covered and the sliding cover mechanism 7 is closed. At this time, it causes incomplete opening and closing, affecting the addition of samples and the heat preservation inside the incubation box 50 and the isolation from the external environment.

[0054] In one embodiment, the sample and TIP supply module 4 includes a bottom plate 40 slidably disposed on the frame 1, a disposable tip holder 41, a sample rack 42, and a reagent storage device 43 disposed on the bottom plate 40. A first barcode scanner 44 is also disposed on the sample and TIP supply module 4. The first barcode scanner 44 is used to scan the sample reagent tubes on the sample rack 42.

[0055] In one embodiment, referring to Figure 3 , the pipetting arm module 2 includes a pipetting arm bracket 20, an X-axis module 21 movable along the X direction on the pipetting arm bracket 20, a Z-axis module 22 movable along the Z direction on the X-axis module 21, and a pipetting gun 23 disposed on the Z-axis module 22.

[0056] Wherein, the X-axis module 21 includes an X-axis guide rail 210 disposed on the pipetting arm bracket 20, an X-axis slider 211 slidably disposed on the X-axis guide rail 210, and an X-axis motor 212 for driving the movement of the X-axis slider 211.

[0057] Among them, the Z-axis module 22 includes a mounting bracket 220 connected to the X-axis slider 211, a Z-axis guide rail 221 provided on the mounting bracket 220, an upper slider 222 and a lower slider 223 that are slidably arranged on the Z-axis guide rail 221 from top to bottom in sequence, a lead screw 224 provided on the mounting bracket 220, and a Z-axis motor 225 for driving the lead screw 224 to rotate. In this embodiment, the Z-axis motor 225 is connected to the lead screw 224 through a belt drive mechanism to drive the lead screw 224 to rotate.

[0058] Among them, a threaded hole (not shown in the figure) that cooperates with the lead screw 224 is penetrated and provided on the upper slider 222, and a through hole (not shown in the figure) for the lead screw 224 to pass through is penetrated and provided on the lower slider 223; the lower end of the lead screw 224 sequentially passes through the threaded hole and the through hole; a spring (not shown in the figure) is connected between the upper slider 222 and the lower slider 223, and the pipette 23 is arranged on the lower slider 223.

[0059] The X-axis motor 212 drives the X-axis slider 211 to move in the X direction, realizing the X-direction movement of the Z-axis module 22 and the pipette 23 thereon. The Z-axis motor 225 drives the lead screw 224 to rotate through the belt drive mechanism. The upper slider 222 that is in threaded cooperation with the lead screw 224 slides along the Z-axis direction under the restriction of the Z-axis guide rail 221, thereby driving the lower slider 223 and the pipette 23 thereon to slide along the Z-axis direction, realizing the X-direction and Z-direction movement of the pipette 23. A spring is connected between the upper slider 222 and the lower slider 223, which is used to realize the flexible contact between the pipette 23 and the pipetting object. Specifically, when sampling the reagent in a test tube, it is required that the disposable pipette tip on the pipette 23 can be inserted into the bottom of the test tube, and at the same time, it is necessary to avoid damage to the test tube or the disposable pipette tip caused by rigid collision; at this time, the upper slider 222 drives the lower slider 223 to move downward. After the disposable pipette tip on the pipette 23 touches the bottom of the test tube, if the upper slider 222 does not stop and continues to move downward, the spring will be compressed. The disposable pipette tip abuts against the bottom of the test tube and no longer moves. The buffering effect of the spring greatly reduces the collision of the disposable pipette tip against the test tube and prevents damage.

[0060] In one embodiment, the chemiluminescence immunoassay analyzer of the present invention also comes with a GPRS communication module, which can be connected to the Internet of Things to realize real-time monitoring of the instrument status (such as the number of sample tests, temperature, background noise value, etc.), maintenance reminder (such as the service life of the drive belt expires, air pressure pump maintenance calibration, etc.), and maintenance alarm (such as abnormal temperature, abnormal background noise value, etc.), and timely notify the maintenance engineer and the operation management center for processing, referring to Figure 11 For the schematic diagram of the working principle of connecting the chemiluminescence immunoassay analyzer of the present invention to the Internet of Things.

[0061] Although the embodiments of the present invention have been disclosed as above, they are not limited to the applications listed in the specification and embodiments. It can be fully applied to various fields suitable for the present invention. For those skilled in the art, additional modifications can be easily made. Therefore, without departing from the general concept defined by the claims and the equivalent scope, the present invention is not limited to specific details.

Claims

1. A chemiluminescence immunoassay analyzer, characterized in that, it includes a frame and a pipetting arm module, a reagent refrigeration module, a sample and TIP supply module, a incubation reaction module, and a waste bin module provided on the frame; wherein, the pipetting arm module has degrees of freedom in the X direction and the Z direction; the reagent refrigeration module is rotatably provided on the frame for refrigerating reagents; the sample and TIP supply module can move in the Y direction on the frame for providing disposable pipette tips, samples to be tested, and reagents; the incubation reaction module is used for performing incubation reactions, and an electric lid-opening mechanism is provided thereon; the electric lid-opening mechanism includes a box body cover plate provided on the incubation box of the incubation reaction module, a support seat provided on the side wall of the incubation box, a rotating shaft pivotally connected to the support seat, a worm gear fixedly connected to the rotating shaft, an L-shaped connecting rod with a first end fixedly connected to the rotating shaft and a second end fixedly connected to the box body cover plate, a first motor provided on the frame, and a worm gear drivingly connected to the output shaft of the first motor for cooperatively driving the worm gear to rotate; a baffle is provided at the end of the rotating shaft, and a photoelectric switch cooperating with the baffle is provided on the rotating shaft; a microfluidic disc is provided in the incubation reaction module, and the microfluidic disc has an injection port, a reaction groove, and a detection cavity; a sliding cover mechanism is provided on the box body cover plate, and the sliding cover mechanism includes a sliding base provided on the box body cover plate, a sampling window opened on the sliding base and communicating with the inside of the incubation box, a sliding block slidably provided at the bottom of the sliding base, and a driving mechanism for driving the sliding block to slide back and forth horizontally in the sliding base; a first inductive optocoupler and a second inductive optocoupler are further provided at the bottom of the sliding base, and the first inductive optocoupler and the second inductive optocoupler are in the same straight line longitudinally; a sampling notch for cooperating with the sampling window, a first optocoupler hole for cooperating with the first inductive optocoupler, and a second optocoupler hole for cooperating with the second inductive optocoupler are further opened on the sliding block, and the first optocoupler hole and the second optocoupler hole are not in the same straight line either longitudinally or horizontally; the sample and TIP supply module includes a bottom plate slidably provided on the frame and a disposable tip holder, a sample rack, and a reagent storage device provided on the bottom plate, and a first barcode scanner is further provided on the sample and TIP supply module.

2. The chemiluminescence immunoassay analyzer according to claim 1, characterized in that, the driving mechanism includes a second motor provided on the sliding base, a runner drivingly connected to the output shaft of the second motor, and a turning handle connected to the bottom of the runner; a longitudinal chute perpendicular to the sliding direction of the sliding block is opened on the sliding block, and the turning handle is cooperatively inserted into the chute to drive the sliding block to perform a horizontal linear motion.

3. The chemiluminescence immunoassay analyzer according to claim 1, characterized in that, The pipetting arm module includes a pipetting arm bracket, an X-axis module that can move along the X direction on the pipetting arm bracket, a Z-axis module that can move along the Z direction on the X-axis module, and a pipette disposed on the Z-axis module.

4. The chemiluminescence immunoassay analyzer according to claim 3, characterized in that the X-axis module includes an X-axis guide rail disposed on the pipetting arm bracket, an X-axis slider slidably disposed on the X-axis guide rail, and an X-axis motor for driving the movement of the X-axis slider.

5. The chemiluminescence immunoassay analyzer according to claim 4, characterized in that the Z-axis module includes a mounting bracket connected to the X-axis slider, a Z-axis guide rail disposed on the mounting bracket, an upper slider and a lower slider slidably disposed on the Z-axis guide rail in sequence from top to bottom, a lead screw disposed on the mounting bracket, and a Z-axis motor for driving the rotation of the lead screw; a threaded hole matching the lead screw is formed through the upper slider, and a through hole for the lead screw to pass through is formed through the lower slider; the lower end of the lead screw sequentially passes through the threaded hole and the through hole; a spring is connected between the upper slider and the lower slider, and the pipette is disposed on the lower slider.

6. The chemiluminescence immunoassay analyzer according to claim 5, characterized in that it further includes a GPRS communication module for connecting the chemiluminescence immunoassay analyzer to the Internet of Things, realizing functions such as real-time monitoring of the instrument status, maintenance reminder, and maintenance alarm, and being able to timely notify the maintenance engineer and the operation management center for processing.

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