A body fluid extractor

Abstract

The present invention relates to a body fluid extractor, comprising: a guide wire and a catheter. The guide wire includes a soft tip and a guide wire body, and the soft tip is connected to the distal end of the guide wire body. The guide wire body is inside the catheter, and a cavity is designed between the inner wall of the catheter and the guide wire body. The guide wire is longer than the catheter, and at least one end of the guide wire body is located inside the catheter. Wherein, in the unopened state, the soft tip is close to the distal part of the catheter and is located inside the catheter for blocking the catheter. In the opened state, the guide wire body can be pushed to separate the soft tip from the catheter to expose the distal end of the catheter. The beneficial effect of the designed human body fluid extractor is to avoid other liquids in the human body from entering the catheter cavity during the process of the catheter entering the human body to the designated position. It overcomes the defect that when the existing catheter-type extraction device takes liquid at the designated position, other liquids are doped in the specimen and the quality of the specimen is not high.

Description

Technical Field

[0001] The present invention relates to the field of medical devices, and particularly to a body fluid extractor. Background Art

[0002] Human body fluids include intracellular fluid, extracellular fluid, gastric juice, intestinal juice, urine, etc. When the human body is diseased, significant changes will occur in the pH value, conductivity, types and quantities of bacteria in the body fluids. Clinically, it is often necessary to extract various body fluid specimens for testing to evaluate the causes of various diseases.

[0003] The human digestive tract is composed of the esophagus, stomach, duodenum, jejunum, ileum, colon and rectum. The digestive fluid in the digestive tract is an important specimen for the diagnosis of digestive tract diseases. At present, although the digestive fluids above the duodenum of the stomach, esophagus and duodenum can be obtained by gastroscopy, and the digestive fluids of the colorectum can also be obtained by colonoscopy, there is still no special instrument for extracting the above digestive fluids in clinical practice. In addition, due to the high requirements for equipment and operation techniques of the enteroscope, and the enteroscope itself is time-consuming and laborious, there is still no simple and convenient method for obtaining the digestive fluids of the duodenum, jejunum and ileum below the ligament of Treitz to be widely promoted in clinical practice.

[0004] In the human urinary system, the primary urine is formed in the renal capsule cavity, stored in the bladder through the ureter, and then discharged out of the body through the urethra. When urinary calculi, urinary tract infections or other urinary system diseases occur, it is necessary to extract the urine in the renal capsule cavity or bladder clinically to accurately evaluate the location or cause of the disease. At present, when extracting the above body fluids, clinical practice generally uses ureteral stents or catheters for indirect extraction of specimens, but there is a risk of specimen contamination by other parts. Summary of the Invention

[0005] The present invention provides a body fluid extractor, which will solve the technical problems that there is no special body fluid extractor in clinical practice or the quality of specimens extracted by existing liquid extractors is poor.

[0006] The technical solution provided by the present invention is as follows:

[0007] A body fluid extractor, comprising:

[0008] A guide wire, the guide wire includes a soft head and a guide wire body, and the soft head is connected to the distal end of the guide wire body;

[0009] A catheter, the other end of the guide wire body passes through the catheter, and there is a cavity between the inner wall of the catheter and the guide wire body;

[0010] Wherein, in the unopened state, the part of the soft head close to the distal end of the catheter is located inside the catheter for blocking the catheter;

[0011] When in the open state, the guide wire body can be pushed to separate the soft tip from the catheter, so as to expose the distal end of the catheter.

[0012] In this technical solution, by connecting the soft tip to the guide wire and passing the guide wire through the catheter, the length of the guide wire is longer than that of the catheter. When not in use, the soft tip part is located inside the catheter to block the catheter, so that no other liquid will enter the catheter during the process of the extractor entering the sampling position; when the end of the sampler with the soft tip enters the predetermined position, at this time, the guide wire is pushed, and the main body part of the guide wire at the end connected with the soft tip extends out of the catheter. At this time, the soft tip is separated from the catheter, so that the catheter near the part to be extracted liquid exposes the catheter lumen. At this time, a suction device can be connected to the other end of the catheter for liquid suction sampling. After sampling, the guide wire body can be pulled, so that the soft tip part blocks the catheter. When the sampler is withdrawn from the human body, the extracted body fluid will not leak out from the catheter lumen. The whole process is very convenient and fast, and can ensure better quality of the extracted liquid.

[0013] Preferably, it further includes a guide wire handle, and one end of the guide wire handle is connected to the proximal end of the guide wire body;

[0014] Wherein, in the unopened state, the soft tip is located inside the catheter, and the guide wire handle and part of the guide wire body are located outside the catheter;

[0015] When in the open state, the guide wire handle is hermetically connected to the end of the catheter away from the soft tip, and the guide wire handle communicates with the catheter, and the guide wire body pushes the soft tip out of the catheter.

[0016] In this technical solution, by providing a guide wire handle, the guide wire handle communicates with the catheter. During use, the guide wire handle is connected to the catheter, and the connection is a sealed connection. When sucking liquid, a syringe or an external liquid suction device can be connected to the guide wire handle for liquid suction. When sucking liquid, a negative pressure is formed in the catheter lumen to suck the small intestinal fluid into the catheter lumen and then into the guide wire handle and be stored by the external suction device. The sampler can extract the small intestinal fluid according to the required sampling volume. After extraction, the guide wire body is pulled to make part of it located inside the catheter to block the guide wire body.

[0017] Preferably, a suction port penetrating the guide wire handle is provided on the guide wire handle. The end of the guide wire body away from the soft tip is connected to the end of the suction port close to the catheter, and a gap is provided between the outer wall of the end of the guide wire body away from the soft tip and the inner wall of the end of the suction port close to the catheter.

[0018] In this technical solution, a suction port is provided on the handle. The guide wire is connected to the inner wall of the suction port with a gap. When pumping liquid, a syringe or an external liquid pumping device can be connected to the guide wire handle to pump the liquid, creating a negative pressure in the catheter lumen. When using small intestinal fluid, it enters the syringe or the liquid pumping device along the gap at the catheter lumen and the suction port. At this time, the sampler can take the liquid according to the required amount of liquid, and the operation is convenient and fast.

[0019] Preferably, the guide wire handle includes a sealing part and a connecting part. The sealing part is used to connect with the catheter, and the connecting part is used to connect with an external liquid sampling device.

[0020] Preferably, the catheter includes a main tube part and a connector part. The connector part is arranged at one end away from the soft head. A cavity is provided inside the connector part. The connector part is communicated with the main tube part. An interface communicated with the cavity is provided on the connector part. The interface is used for supporting use with an external medical device. When in the open state, the end of the connector part away from the main tube part is detachably and sealingly connected to the guide wire handle.

[0021] In this technical solution, by setting the catheter into a main tube part and a connector part, the connector part is used to connect with the guide wire handle. When in use, the guide wire handle and the connector part are detachably and sealingly connected to form a negative pressure during use, so that small intestinal fluid can be pumped out.

[0022] Preferably, the connecting part is a Luer connector, and the sealing part is a Luer connector or a tower connector;

[0023] and / or;

[0024] The end of the connector part away from the soft head is a Luer connector or a tower connector for detachably and sealingly connecting with the guide wire handle; the interface is a Luer connector or a tower head for supporting use with an external medical device.

[0025] Preferably, the middle part of the soft head is enlarged and both ends are in a conical structure, and the size of the soft head gradually increases from both ends to the middle part of the soft head.

[0026] In this technical solution, by setting the soft head into a form with both ends conical and the middle part enlarged, when it is not opened, part of the soft head can be located inside the catheter, and the shape of the soft head part enables the extractor to play a good guiding role when entering the human body, making the whole operation process very convenient and not easily stuck.

[0027] Preferably, the soft head is made of TPU material and contains a developer.

[0028] In this technical solution, a developer is provided on the soft tip so that the position of the soft tip can be well judged by the developer during use, which is beneficial to the operation of the doctor. During specific implementation, the developer can be mixed with the material of the soft tip to prepare the soft tip, or the developer can be added to the surface of the soft tip.

[0029] Preferably, the developer material is one of barium sulfate and tungsten, and the proportion of the developer is 20% - 50%.

[0030] Preferably, scale line marks are provided on the outer wall of the guide wire main body at intervals along the length direction of the guide wire.

[0031] In this technical solution, by providing scale line marks at intervals on the outer wall of the guide wire main body, the positions of the catheter and the guide wire main body can be well observed during use, so that the process of small intestinal fluid extraction is more accurate.

[0032] Preferably, a hydrophilic coating is provided on the outer wall of the guide wire main body;

[0033] and / or;

[0034] The outer wall of the catheter is coated with a hydrophilic coating.

[0035] In this technical solution, by providing a hydrophilic coating on the outer wall of the guide wire, the relative friction between the guide wire main body and the extraction catheter is reduced, so that the guide wire main body can be very smooth during pushing or pulling.

[0036] By coating a hydrophilic coating on the outer wall of the catheter, the friction between the catheter main body and the gastroscope, colonoscope or gastrointestinal intubation and the inner wall of the human digestive tract is reduced. It can not only better push the catheter into the human body, but also avoid damage to the inner wall of the digestive tract caused by the outer wall of the catheter.

[0037] Preferably, the solute of the hydrophilic coating is one or several of polyvinylpyrrolidone, polyethylene glycol, polyacrylic acid, polyacrylamide, coupling agent, crosslinking agent, surfactant;

[0038] The solvent of the hydrophilic coating is one or several of ethanol, acetone, ethyl acetate, tetrahydrofuran, dichloromethane, dioxane, methyl ethyl ketone, hexafluoroisopropanol.

[0039] Compared with the prior art, a body fluid extractor provided by the present invention has the following beneficial effects:

[0040] 1. In the present invention, the guide wire body is passed through the catheter, and a soft tip is connected to the guide wire body. The soft tip part seals the catheter, preventing other liquids in the human body from entering the catheter lumen during the process of the catheter entering the human body to the designated position. As a result, when extracting liquid at the designated position, the extracted liquid will not be contaminated with other liquids, ensuring high-quality specimens. When reaching the designated position, the guide wire body can be pushed to separate the soft tip from the catheter, enabling the catheter to better extract liquid. Moreover, compared with existing liquid extraction devices, the amount of liquid extraction can be adjusted according to the doctor's needs, and the extraction operation process is simple and convenient.

[0041] 2. In the present invention, a guide wire handle is provided, and during use, the guide wire handle can be detachably and sealingly connected to the catheter. When extracting small intestinal fluid, a negative pressure can be formed in the catheter lumen, enabling the small intestinal fluid to quickly enter the syringe or liquid extraction device along the catheter lumen and the guide wire handle. The entire process is convenient and fast.

[0042] 3. In the present invention, a developer is provided on the guide wire body or the soft tip to better observe the position of the extractor during use, facilitating better operation by the doctor.

[0043] 4. In the present invention, a hydrophilic coating is provided on the outer wall of the guide wire body and on the outer wall of the catheter. When pushing or pulling the guide wire body, the operation can be smooth, without being difficult to operate due to the large frictional force between the guide wire body and the inner wall of the catheter. Similarly, the hydrophilic coating on the outer wall of the catheter reduces the frictional force between the catheter body and the gastroscope, colonoscope, or gastrointestinal intubation and the inner wall of the human digestive tract. This not only enables better insertion of the catheter into the human body but also avoids damage to the inner wall of the digestive tract by the outer wall of the catheter, making the operation safer.

[0044] 5. The amount of small intestinal fluid extracted by the small intestinal fluid extractor in the present invention can be adjusted according to requirements, and it has the advantages of high-quality specimens, low cost, stable performance, and simple production process. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] The above characteristics, technical features, advantages, and their implementation methods of a body fluid extractor will be further described below in a clear and understandable manner in combination with the drawings in the preferred embodiments.

[0046] Figure 1 is a schematic structural diagram of the unopened state of the present invention;

[0047] Figure 2 is a schematic structural diagram of the opened state of the present invention;

[0048] Figure 3 is a partial cross-sectional structural diagram of the guide wire of the present invention;

[0049] Figure 4It is a schematic cross-sectional structure diagram after the present invention is in the open state;

[0050] Figure 5 It is a schematic structure diagram of the guide wire of the present invention.

[0051] Explanation of the reference numerals in the attached drawings: 100, guide wire; 110, guide wire handle; 111, suction port; 120, guide wire body; 130, soft tip; 200, catheter; 210, joint part; 220, main tube part. Detailed implementation manners

[0052] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will describe the specific implementation manners of the present invention with reference to the accompanying drawings. Obviously, the accompanying drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings, and other implementation manners can also be obtained.

[0053] To make the drawings concise, only the parts related to the present invention are schematically shown in each drawing, and they do not represent their actual structures as products. Additionally, to make the drawings concise and easy to understand, in some drawings, for components with the same structure or function, only one of them is schematically shown, or only one of them is labeled. In this document, "one" not only means "only this one", but also means "more than one" situation.

[0054] According to an embodiment provided by the present invention, as Figures 1-5As shown in the figure, a body fluid extractor includes a guide wire 100 and a catheter 200. The guide wire 100 includes a soft tip 130 and a guide wire body 120. The soft tip 130 is connected to one end of the guide wire body 120 (i.e., the distal end of the guide wire body 120). The other end of the guide wire body 120 passes through the catheter 200. There is a cavity between the inner wall of the catheter 200 and the guide wire body 120. The guide wire 100 is longer than the catheter 200, and at least one end of the guide wire body 120 is located inside the catheter 200. Among them, in the unopened state, and a part of the soft tip 130 close to one end of the catheter 200 (i.e., the distal end of the catheter 200) is located inside the catheter 200 for blocking the catheter 200. In the opened state, the guide wire body 120 can be pushed to separate the soft tip 130 from the catheter 200, so as to expose one end of the catheter 200 close to the soft tip 130 (i.e., the distal end of the catheter 200). In specific implementation, the guide wire body 120 is made of a metal guide wire 100 such as stainless steel or nitinol wire, and can be detected under an X-ray machine or a CT ray. In specific implementation, the outer wall of the guide wire 100 can be sandblasted at intervals along the length direction of the guide wire 100 to achieve ultrasonic imaging. Scale line marks are arranged at intervals along the length direction of the outer wall of the guide wire body 120, so as to facilitate judging the position of the soft tip through the scale marks of the guide wire well during subsequent body fluid extraction. At the same time, a hydrophilic coating of TPU or PTFE is coated on the outer wall of the guide wire body 120 to reduce the relative friction between the guide wire body 120 and the extractor catheter 200. The main body of the hydrophilic coating material is PVP, and it is chemically grafted with the guide wire body 120 through a coupling agent to achieve a firm coating. The outer diameter of the guide wire 100 is 0.3 - 0.8 mm, preferably 0.5 - 0.6 mm, which provides a certain supporting force for the extractor catheter 200 on the premise of not affecting the liquid extraction and liquid storage performance of the extractor catheter 200.

[0055] In this embodiment, as Figures 1-2 and Figure 4As shown, the guide wire handle 110 includes a sealing portion and a connecting portion. The sealing portion is used to connect with the catheter, and the connecting portion is used to connect with an external liquid extraction device. The connecting portion is a Luer connector, and the sealing portion is a Luer connector or a flare fitting. The catheter 200 includes a main tube portion 220 and a connecting head portion 210. The inner diameter of the main body portion of the catheter 200 is 1.0 - 1.5 mm, and the outer diameter is 1.5 - 2.0 mm. The connecting head portion 210 is provided at one end away from the soft tip 130. There is a cavity inside the connecting head portion 210. The connecting head portion 210 communicates with the main tube portion 220. There is an interface on the connecting head portion 210 that communicates with the cavity. The interface is used to be used in supporting with external medical devices. The end of the connecting head portion 210 away from the soft tip is a Luer connector or a flare fitting, and is used for detachable and sealed connection with the guide wire handle 110; the interface is a Luer connector or a flare head, and is used for supporting with external medical devices. When in the open state, the end of the connecting head portion 210 away from the main tube portion 220 is detachably and sealedly connected with the guide wire handle 110. The main body portion of the catheter 200 is a tube formed by extrusion molding of high molecular materials such as TPU, PEEK, PE, PA, etc. The outer wall of the catheter 200 is coated with a hydrophilic coating to reduce the friction between the main body of the catheter 200 and the gastroscope, colonoscope, or gastrointestinal intubation tube and the inner wall of the human digestive tract. Among them, the hydrophilic coating material is one or several of hydrophilic high molecular materials such as PVP or PEG, PEO, PVA, etc., and is chemically grafted with the main body of the catheter 200 through a coupling agent to achieve a firm coating. The hydrophilic coating solute is one or several of polyvinylpyrrolidone, polyethylene glycol, polyacrylic acid, polyacrylamide, coupling agent, crosslinking agent, surfactant; the hydrophilic coating solvent is one or several of ethanol, acetone, ethyl acetate, tetrahydrofuran, dichloromethane, dioxane, methyl ethyl ketone, hexafluoroisopropanol.

[0056] During specific implementation, as Figure 2 and Figure 5 shown, the middle part of the soft tip 130 is enlarged and both ends are tapered. And the size of the soft tip 130 gradually increases from both ends to the middle part of the soft tip 130. The gradually changing size is designed in an arc shape, with smaller sizes at both sides and a larger size in the middle. One is to guide the extractor catheter 200 to pass through the curved tissue of the digestive tract, and the other is to block the catheter 200. The sizes at both ends are 0.5 - 0.8 mm; the maximum size in the middle is 1.0 - 1.5 mm. The soft tip 130 is composed of TPU or spring wire, with good bending and flexibility, and can guide the extractor to pass through the curved tissue without damaging the inner wall of the digestive tract. A developer may be provided on the soft tip 130. During implementation, the soft tip can be made of TPU or spring wire. When prepared from TPU, the developer can be co-extruded and formed with the TPU material, or a layer of developer can be coated on the surface of the soft tip. When it is a spring wire, a layer of developer can be coated on the surface of the spring wire to increase the detectability under an X-ray machine or a CT ray. The developer material is one of barium sulfate and tungsten, and the proportion of the developer is 20% - 50%.

[0057] In this embodiment, the length of the extractor is 1.5 to 4.5 m, preferably 2.0 to 4.0 m, and it can reach the small intestine position.

[0058] In another embodiment of the present invention, referring again to Figures 1-5 As shown, it further includes a guide wire handle 110, and one end of the guide wire handle 110 is connected to the end of the guide wire body 120 away from the soft head 130; wherein, in the unopened state, the soft head 130 is located inside the catheter 200, and the end of the guide wire body 120 away from the soft head 130 is located outside the catheter 200; specifically, as Figures 3-4 As shown, a suction port 111 penetrating the guide wire handle 110 is provided on the guide wire handle 110. The end of the guide wire body 120 away from the soft head 130 is connected to the end of the suction port 111 close to the catheter 200, and a gap is provided between the outer wall of the end of the guide wire body 120 away from the soft head 130 and the inner wall of the end of the suction port 111 close to the catheter 200. The formed gap is beneficial to forming a negative pressure during the liquid extraction process when the guide wire handle 110 is connected to an external liquid extraction device after the guide wire handle 110 is connected to the catheter 200. The connection method between the guide wire body 120 and the guide wire handle 110 is a welding connection method, so that liquid can pass through. The sealing part of the guide wire handle 110 is a Luer connector or a tower connector. The connection method between the guide wire handle 110 and the joint part 210 can be in a form of direct clamping or a threaded connection. In the opened state, the guide wire handle 110 is detachably and sealingly connected to the end of the catheter 200 away from the soft head 130, and the guide wire handle 110 communicates with the catheter 200. The guide wire body 120 pushes the soft head 130 out of the catheter 200. In this embodiment, the specific form of the guide wire handle 110 is not limited as long as the guide wire handle 110 can achieve a sealing effect after being connected to the joint part 210 of the catheter 200, and the two can be disassembled after the liquid is extracted.

[0059] During use, the specific steps of use are as follows:

[0060] 1. Before the small intestine fluid extractor is inserted into the human digestive tract, the state is as Figure 1 As shown, the soft head 130 of the guide wire 100 partially blocks the main pipe part 220 of the catheter 200 to ensure that the inner wall of the catheter 200 is not contaminated by gastric juice or large intestine fluid before the proximal end of the extractor is inserted into the predetermined part of the small intestine;

[0061] 2. After the extraction fluid reaches the predetermined part of the small intestine, push the guide wire 100 to sealingly connect the guide wire handle 110 to the joint part 210 of the catheter 200. At this time, the soft head 130 part of the guide wire 100 is separated from the catheter 200, and the lumen of the catheter 200 is exposed (as Figure 2 shown).

[0062] 3. Connect the syringe to the Luer connector of the guide wire handle 110, aspirate the syringe, a negative pressure is formed in the inner cavity of the catheter 200, intestinal fluid enters the cavity of the catheter 200, after the aspiration volume reaches a predetermined value, pull the guide wire 100 to make the soft tip 130 of the guide wire 100 partially block the catheter 200 (again as shown in Figure 1 );

[0063] 4. Take out the extractor from the digestive tract, push the guide wire 100, and release the stored small intestinal fluid into a designated container, thus completing the extraction of small intestinal fluid (again as shown in Figure 1 ).

[0064] It should be noted that the above embodiments can be freely combined as needed. The above are only the preferred embodiments of the present invention. It should be pointed out that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. A body fluid extractor, characterized in that, Comprising: A guide wire, the guide wire includes a soft tip and a guide wire body, the soft tip is connected to the distal end of the guide wire body, and the soft tip contains a developer; A catheter, the other end of the guide wire body passes through the catheter, and a cavity is provided between the inner wall of the catheter and the guide wire body; A guide wire handle, one end of the guide wire handle is connected to the proximal end of the guide wire body, and the guide wire handle includes a sealing portion and a connecting portion, the sealing portion is used to connect with the catheter, and the connecting portion is used to connect with an external liquid extraction device; An aspiration port penetrating through the guide wire handle is provided on the guide wire handle, one end of the guide wire body away from the soft tip is connected to one end of the aspiration port close to the catheter, and a gap is provided between the outer wall of the end of the guide wire body away from the soft tip and the inner wall of the end of the aspiration port close to the catheter; Wherein, in the unopened state, the part of the soft tip close to the distal end of the catheter is located inside the catheter for blocking the catheter, and the guide wire handle and part of the guide wire body are located outside the catheter; In the opened state, the guide wire body can be pushed so that the soft tip is separated from the catheter to expose the distal end of the catheter; at the same time, the guide wire handle communicates with the catheter, and the guide wire handle is hermetically connected to the end of the catheter away from the soft tip, so as to directly dock with an external liquid extraction device through the aspiration port for body fluid extraction.

2. The body fluid extractor according to claim 1, wherein: The catheter includes a main tube portion and a connector portion, the connector portion is arranged at the end away from the soft tip, a cavity is provided inside the connector portion, the connector portion communicates with the main tube portion, and an interface communicating with the cavity is provided on the connector portion, the interface is used for supporting use with external medical devices, and in the opened state, the end of the connector portion away from the main tube portion is detachably and hermetically connected to the guide wire handle.

3. The body fluid extractor according to claim 1, wherein: The connecting portion is a Luer connector, and the sealing portion is a Luer connector or a tower connector.

4. The body fluid extractor according to claim 2, wherein: The end of the connector portion away from the soft tip is a Luer connector or a tower connector for detachably and hermetically connecting with the guide wire handle; the interface is a Luer connector or a tower head for supporting use with external medical devices.

5. The body fluid extractor according to claim 1, characterized in that: The middle of the soft tip is enlarged and both ends are in a conical structure, and the size of the soft tip gradually increases from both ends to the middle of the soft tip.

6. The body fluid extractor according to claim 1, characterized in that: The soft tip is made of TPU material.

7. The body fluid extractor according to claim 1, wherein: The developer material is one of barium sulfate and tungsten, and the proportion of the developer is 20% - 50%.

8. The body fluid extractor according to claim 1, wherein: Scale line marks are provided at intervals along the length direction of the guide wire on the outer wall of the guide wire body.

9. The body fluid extractor according to claim 1, wherein: A hydrophilic coating is provided on the outer wall of the guide wire body; And / or; The outer wall of the catheter is coated with a hydrophilic coating.

10. The body fluid extractor according to claim 9, wherein, The solute of the hydrophilic coating is one or several of polyvinylpyrrolidone, polyethylene glycol, polyacrylic acid, polyacrylamide, coupling agent, crosslinking agent, and surfactant; The hydrophilic coating solvent is one or more of ethanol, acetone, ethyl acetate, tetrahydrofuran, dichloromethane, dioxane, methyl ethyl ketone, and hexafluoroisopropanol.

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