-80℃ automated biological sample storage structure

Abstract

The present invention relates to the technical field of ultra-low temperature biological sample automated storage equipment, specifically to an ‑80°C automated biological sample storage structure, comprising an annular top plate and an annular bottom plate facing each other from top to bottom, a disc sealing plate fixed to the top surface of the annular top plate, column plates evenly distributed along the circumferential direction between the annular top plate and the annular bottom plate, the upper and lower ends of the column plates are respectively fixed to the annular top plate and the annular bottom plate, and sample box storage racks are evenly distributed along the vertical direction between two adjacent column plates. The present invention adopts a squirrel cage storage structure, which has a larger storage density and storage capacity than the prior art, and allocates a fixed storage address to each storage area according to a fixed numbering rule, and can achieve fast and accurate access operations in each storage area in conjunction with a control algorithm and a control strategy.

Description

Technical Field

[0001] The present invention relates to the technical field of ultra-low temperature biological sample automated storage equipment, in particular to a -80°C automated biological sample storage structure. Background Art

[0002] At present, in the past decade or so, a lot of research and practice activities on the automated storage of biological samples in ultra-low temperature environments have been carried out at home and abroad. In the initial stage, the operation and storage environment of related products were mainly concentrated at -20℃ and -80℃, and related products have been used in some internationally renowned large sample libraries. In theory, the lower the storage temperature of biological samples, the closer they are to the state when they are out of the body. For short-term storage, a -20℃ automated storage system can be selected. For strategically collected samples, due to the longer storage time, -80℃ and -196℃ automated storage systems are generally used.

[0003] The development trend of biological sample banks in the future is towards high automation, high throughput, high quality, high efficiency, high reliability, high stability, big data and artificial intelligence. The number of samples in a medium-sized sample bank has exceeded hundreds of thousands, and the number of samples in a large sample bank is often in the millions. Under such a volume, the traditional manual processing, storage and calling of samples are obviously not efficient enough. The sample storage equipment in the existing technology has low storage capacity and density and is difficult to find, which is difficult to keep up with the needs of the times and the rapid development of science and technology. For this reason, we proposed a -80℃ automated biological sample storage structure to solve the above drawbacks. Summary of the invention

[0004] The purpose of the present invention is to provide a -80°C automated biological sample storage structure, which is used to expand the capacity and density of the sample storage structure and facilitate user search.

[0005] The above-mentioned object of the present invention is achieved through the following technical solutions:

[0006] -80℃ automated biological sample storage structure, comprising a circular top plate and a circular bottom plate facing each other vertically, a disc sealing plate being fixedly arranged on the top surface of the circular top plate, column plates being evenly distributed along the circumferential direction between the circular top plate and the circular bottom plate, the upper end and the lower end of the column plate being respectively fixedly connected to the circular top plate and the circular bottom plate, and sample box storage racks being evenly distributed along the vertical direction between two adjacent column plates;

[0007] There are a total of 26 column plates, and the angle between two adjacent column plates is 12 degrees; two seventh bolt holes are provided at the upper and lower ends of the column plates, 23 slots are evenly provided on both side walls of the column plates, and five eighth bolt holes are provided on the side edges of the column plates; the width of the slots is 1.5 mm, and the depth is 3 mm;

[0008] The outer sides of the column plates are fitted with positioning bars for fixing the position of the sample box storage rack, and the positioning bars are penetrated by a ninth bolt hole for connecting with the column plates;

[0009] The sample box storage rack is an integrally formed structure, and both sides thereof are provided with span ears for matching with the slots, and the thickness of the span ears is 1.5 mm.

[0010] Preferably, fifteen first bolt holes are evenly formed on the top surface of the annular top plate for connection with the disc cover plate, and thirty pairs of second bolt holes are evenly formed on the bottom surface of the annular top plate for connection with the column plate.

[0011] Preferably, fifteen third bolt holes are evenly formed on the bottom surface of the annular bottom plate for connection with the ultra-low temperature space platform, and thirty pairs of fourth bolt holes are evenly formed on the top surface of the annular bottom plate for connection with the column plate.

[0012] Preferably, fifth bolt holes are evenly opened along the circumferential direction on the outer periphery of the top surface of the disc sealing plate for connection with the annular top plate, and five sixth bolt holes and three process avoidance holes are opened through the top surface of the disc sealing plate.

[0013] Compared with the prior art, the present invention provides a -80°C automated biological sample storage structure, which has the following beneficial effects:

[0014] 1. The present invention adopts a squirrel cage storage structure, which has a larger storage density and storage capacity than the prior art, and allocates a fixed storage address to each storage area according to a fixed numbering rule. With the control algorithm and control strategy, fast and accurate access operations can be achieved in each storage area;

[0015] 2. The storage structure of the present invention is fixed and static. Compared with the prior art, it avoids the defects of large rotational inertia and sacrificed space of the rotating storage structure. The power source of all actuators is not inside the storage space, avoiding the influence of ultra-low temperature on electrical performance. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a schematic diagram of the structure of the present invention;

[0017] Figure 2 This is a schematic diagram of the structure of the circular ring top plate of the present invention;

[0018] Figure 3 This is a schematic diagram of the structure of the annular bottom plate of the present invention;

[0019] Figure 4 This is a schematic diagram of the disc sealing plate structure of the present invention;

[0020] Figure 5 It is a schematic diagram of the column plate structure of the present invention;

[0021] Figure 6 This is a schematic diagram of the structure of the sample box storage rack of the present invention;

[0022] Figure 7 This is a schematic diagram of the positioning bar structure of the present invention.

[0023] In the figure: 1, circular top plate; 11, first bolt hole; 12, second bolt hole; 2, circular bottom plate; 21, third bolt hole; 22, fourth bolt hole; 3, disc sealing plate; 31, fifth bolt hole; 32, sixth bolt hole; 33, process avoidance hole; 4, column plate; 41, seventh bolt hole; 42, slot; 43, eighth bolt hole; 5, sample box storage rack; 51, cross ear; 6, positioning bar; 61, ninth bolt hole. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] Example: See Figure 1 , -80℃ automated biological sample storage structure, including a circular top plate 1 and a circular bottom plate 2 facing each other, both with an outer diameter of 1200mm and an inner diameter of 1040mm, a disc sealing plate 3 is fixed on the top surface of the circular top plate 1, and the diameter of the disc sealing plate 3 is also 1200mm, and column plates 4 are evenly distributed along the circumferential direction between the circular top plate 1 and the circular bottom plate 2, and the number of column plates 4 is 26, and the angle between two adjacent column plates 4 is 12 degrees. Because the angle is 12 degrees, theoretically there are 30 in total, but because it needs to be installed with an automatic storage and retrieval mechanism and its automatic The rotation angle of the body is limited, and there are actually only 26. The upper end and the lower end of the column plate 4 are fixedly connected to the circular top plate 1 and the circular bottom plate 2 respectively, and sample box storage racks 5 are evenly distributed between two adjacent column plates 4 in the vertical direction. There are a total of 23 sample box storage racks 5 between two adjacent column plates 4. The outer sides of the column plates 4 are all fitted with positioning strips 6 for fixing the positions of the sample box storage racks 5. The above structure together constitutes a squirrel cage storage device with a height of 1595mm and a diameter of 1200mm, which can hold up to 130,000 sample data at one time.

[0026] See also Figure 2-Figure 7, the top surface of the circular top plate 1 is uniformly provided with fifteen first bolt holes 11, specifically M6 bolt holes, for connecting with the disc sealing plate 3, and the bottom surface of the circular top plate 1 is uniformly provided with thirty pairs of second bolt holes 12, specifically M6 hexagonal bolt holes, for connecting with the column plate 4. The bottom surface of the circular bottom plate 2 is uniformly provided with fifteen third bolt holes 21, specifically M8 threaded holes, for connecting with the ultra-low temperature space platform, and the top surface of the circular bottom plate 2 is uniformly provided with thirty pairs of fourth bolt holes 22, specifically M6 hexagonal threaded holes, for connecting with the column plate 4; therefore, the circular top plate 1 and the circular bottom plate 2 are both bolted to the column plate 4, and the disc sealing plate 3 is bolted to the circular top plate 1.

[0027] The outer periphery of the top surface of the disc sealing plate 3 is evenly provided with fifth bolt holes 31 along the circumferential direction. The disc sealing plate 3 is made of SUS304 stainless steel with a passivated surface and is used to connect with the circular top plate 2. The fifth bolt hole 31 is an M6 threaded through hole. Five sixth bolt holes 32 and three process avoidance holes 33 are opened through the top surface of the disc sealing plate 3. The sixth bolt hole 32 is an M6 threaded hole and is used to connect with the internal automatic storage and retrieval mechanism.

[0028] The upper and lower ends of the column plate 4 are provided with two seventh bolt holes 41. The column plate 4 is made of aluminum alloy, and the surface is anodized. Its length is 1570mm, its width is 80mm, and its thickness is 15mm. Twenty-three slots 42 are evenly provided on the two side walls of the column plate 4, and five eighth bolt holes 43 are provided on the side of the column plate 4; the width of the slot 42 is 1.5mm and the depth is 3mm. The positioning bar 6 is provided with a ninth bolt hole 61 for connecting with the column plate 4, and the ninth bolt hole 61 matches the eighth bolt hole 43, and the two are fixedly connected after being aligned. The sample box storage rack 5 is an integrated structure, specifically made of SUS304 material, and both sides thereof are provided with cross ears 51 for matching with the slots 42, and the thickness of the cross ears 51 is 1.5mm, so the sample box storage rack 5 is located between two adjacent column plates 4, and the cross ears 51 are slidably connected in the slots 42.

[0029] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the existence of other identical elements in the process, method, article or device including the elements.

[0030] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. -80℃ automated biological sample storage structure, characterized in that: it comprises an annular top plate (1) and an annular bottom plate (2) facing each other vertically, a disc sealing plate (3) is fixedly arranged on the top surface of the annular top plate (1), column plates (4) are evenly distributed along the circumferential direction between the annular top plate (1) and the annular bottom plate (2), the upper end and the lower end of the column plate (4) are respectively fixedly connected to the annular top plate (1) and the annular bottom plate (2), and sample box storage racks (5) are evenly distributed along the vertical direction between two adjacent column plates (4); There are a total of twenty-six column plates (4), and the angle between two adjacent column plates (4) is twelve degrees; two seventh bolt holes (41) are provided at the upper end and the lower end of the column plate (4), twenty-three slots (42) are evenly provided on the two side walls of the column plate (4), and five eighth bolt holes (43) are provided on the side of the column plate (4); the width of the slot (42) is 1.5 mm, and the depth is 3 mm; The outer sides of the column plates (4) are fitted with positioning bars (6) for fixing the position of the sample box storage rack (5), and the positioning bars (6) are penetrated by a ninth bolt hole (61) for connecting with the column plates (4); The sample box storage rack (5) is an integrally formed structure, and is provided with cross ears (51) on both sides thereof for matching with the slots (42), and the thickness of the cross ears (51) is 1.5 mm.

2. The -80°C automated biological sample storage structure according to claim 1 is characterized in that: fifteen first bolt holes (11) are evenly arranged on the top surface of the circular top plate (1) for connecting with the disc sealing plate (3); and thirty pairs of second bolt holes (12) are evenly arranged on the bottom surface of the circular top plate (1) for connecting with the column plate (4).

3. The -80°C automated biological sample storage structure according to claim 1 is characterized in that: fifteen third bolt holes (21) are evenly arranged on the bottom surface of the annular base plate (2) for connection with the ultra-low temperature space platform, and thirty pairs of fourth bolt holes (22) are evenly arranged on the top surface of the annular base plate (2) for connection with the column plate (4).

4. The -80°C automated biological sample storage structure according to claim 1 is characterized in that: fifth bolt holes (31) are evenly arranged along the circumferential direction on the outer periphery of the top surface of the disc sealing plate (3) for connection with the annular top plate (1), and five sixth bolt holes (32) and three process avoidance holes (33) are arranged through the top surface of the disc sealing plate (3).

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