Radio frequency transmission quadrupole power supply circuit and control method thereof, and power supply device

Abstract

The present application relates to a radio frequency transmission quadrupole power supply circuit and a control method and a power supply device thereof, which are provided with a plurality of different radio frequency magnetic ring transformers. When ions of different mass ranges and different mass numbers are transmitted, different radio frequency magnetic ring transformers can be correspondingly selected by a first selection device and a second selection device, thereby realizing ion transmission of an extremely wide mass range from low mass number ions to high mass number ions, generating a radio frequency high voltage electric field that flexibly matches different frequency bands, and achieving excellent wide mass range ion transmission efficiency and instrument sensitivity; at the same time, a closed-loop control architecture is realized through a feedback adjustment device, so that the radio frequency transmission quadrupole power supply circuit has extremely high adaptability and stability, thereby greatly improving the application range of the mass spectrometer.

Description

Technical Field

[0001] The present application relates to the technical field of ion transmission, and in particular to a radio frequency transmission quadrupole power supply circuit and a control method and a power supply device thereof. Background Art

[0002] Mass spectrometry is an analytical method for measuring and analyzing the mass-to-charge ratio (m / q) of the sample ions. First, the uncharged sample to be tested is ionized, and then the ions are separated according to the mass-to-charge ratio by electric or magnetic field methods to obtain a mass spectrum. By analyzing the mass spectrum and related information of the sample, the qualitative and quantitative results of the sample can be obtained. Commonly used mass spectrometers are divided into magnetic deflection mass spectrometers, quadrupole mass spectrometers, ion trap mass spectrometers and time-of-flight mass spectrometers according to the analyzer.

[0003] With the development of mass spectrometry technology, the instrument performance indicators of mass spectrometers are constantly improving, and new methods and technologies are constantly being introduced. Among them, the introduction of RF transmission quadrupole collision cooling and focusing technology in time-of-flight mass spectrometers, as an ion transmission system, has a good effect on improving ion transmission efficiency and enhancing instrument sensitivity. When the RF transmission quadrupole is working, it is necessary to add a radio frequency high voltage electric field with a specific frequency and amplitude. For ions of different mass numbers and mass ranges, the added frequency band and amplitude are very different, which places high demands on the control method and technology of the RF high voltage power supply electric field.

[0004] However, in the current time-of-flight mass spectrometer, for the radio frequency transmission quadrupole, in order to achieve ion transmission in an extremely wide mass range from low mass number ions to high mass number ions, especially the transmission of ions with low mass numbers within 20 to high mass numbers above 4500, to generate a radio frequency high-voltage electric field that flexibly matches different frequency bands, to achieve good wide mass range ion transmission efficiency and instrument sensitivity, as well as adaptability and stability, there is no mature method and solution, which greatly limits the application field of the instrument. Summary of the invention

[0005] Based on this, it is necessary to provide a radio frequency transmission quadrupole power supply circuit and a control method and a power supply device thereof to address the problem that the application field of traditional time-of-flight mass spectrometers is limited.

[0006] A radio frequency transmission quadrupole power supply circuit comprises: a control device, a sine wave generating device, an amplifying device, a first gating device, a second gating device, a plurality of radio frequency magnetic ring transformers, a radio frequency transmission quadrupole and a feedback regulating device, wherein the control device is connected to the sine wave generating device, the sine wave generating device is connected to the amplifying device, the amplifying device is connected to the first gating device, the primary side of each radio frequency magnetic ring transformer is respectively connected to the first gating device, the secondary side of each radio frequency magnetic ring transformer is respectively connected to the second gating device, the second gating device is connected to the radio frequency transmission quadrupole, the radio frequency transmission quadrupole is connected to the feedback regulating device, the feedback regulating device is connected to the control device, the feedback regulating device is connected to the amplifying device, the amplifying device, the first gating device, the secondary side taps of each radio frequency magnetic ring transformer and the second gating device are respectively connected to the control device.

[0007] In one embodiment, the amplifying device includes a variable gain amplifier programmable modulator, a common-phase multi-stage amplifier circuit and an inverting multi-stage amplifier circuit, the variable gain amplifier programmable modulator is connected to the sine wave generating device and the feedback regulating device, the common-phase multi-stage amplifier circuit and the inverting multi-stage amplifier circuit are respectively connected to the variable gain amplifier programmable modulator, the common-phase multi-stage amplifier circuit and the inverting multi-stage amplifier circuit are respectively connected to the first selection device, and the common-phase multi-stage amplifier circuit and the inverting multi-stage amplifier circuit are respectively connected to the control device.

[0008] In one embodiment, the in-phase multi-stage amplifier circuit includes a in-phase amplifier, a first-stage power amplifier and a second-stage power amplifier, the in-phase amplifier is connected to a variable gain amplifier programmable modulator, the in-phase amplifier is connected to the first-stage power amplifier, the first-stage power amplifier is connected to the second-stage power amplifier, the second-stage power amplifier is connected to the first gating device, and the in-phase amplifier, the first-stage power amplifier and the second-stage power amplifier are respectively connected to the control device; and / or, the inverting multi-stage amplifier circuit includes an inverting amplifier, a first-stage amplifier and a second-stage amplifier, the inverting amplifier is connected to a variable gain amplifier programmable modulator, the inverting amplifier is connected to the first-stage amplifier, the first-stage amplifier is connected to the second-stage amplifier, the second-stage amplifier is connected to the first gating device, and the inverting amplifier, the first-stage amplifier and the second-stage amplifier are respectively connected to the control device.

[0009] In one embodiment, the control device includes a main controller, a power supply and current monitor, a gating controller and a medium and low voltage generator, the main controller is connected to the sine wave generating device, the feedback regulating device is connected to the main controller, the power supply and current monitor, the gating controller and the medium and low voltage generator are respectively connected to the main controller, the power supply and current monitor are connected to the amplifying device, the gating controller is connected to the first gating device and the second gating device, and the medium and low voltage generator is connected to the secondary tap of each of the radio frequency magnetic toroidal transformers.

[0010] In one embodiment, the feedback adjustment device includes a detection circuit, an amplitude monitor, a digital-to-analog controller and a proportional-integral regulator, the detection circuit is connected to the RF transmission quadrupole, the detection circuit is connected to the proportional-integral regulator and the amplitude monitor, the amplitude monitor and the digital-to-analog controller are respectively connected to the control device, the digital-to-analog controller is connected to the proportional-integral regulator, and the proportional-integral regulator is connected to the amplification device.

[0011] A control method for a radio frequency transmission quadrupole power supply circuit as described above comprises: obtaining a frequency setting value; controlling the first gating device and the second gating device to gating the corresponding radio frequency magnetic ring transformer according to the frequency setting value; and obtaining the resonant frequency of the radio frequency transmission quadrupole power supply circuit at minimum power consumption by adjusting the sine wave generating device and the feedback regulating device.

[0012] In one embodiment, the radio frequency magnetic toroidal transformer includes a low-frequency radio frequency magnetic toroidal transformer, a medium-frequency radio frequency magnetic toroidal transformer and a high-frequency radio frequency magnetic toroidal transformer, and the step of controlling the first gating device and the second gating device to select the corresponding radio frequency magnetic toroidal transformer according to the frequency setting value includes: comparing and analyzing the frequency setting value with a preset first frequency range; when the frequency setting value is within the preset first frequency range, controlling the first gating device and the second gating device to select the low-frequency radio frequency magnetic toroidal transformer; when the frequency setting value is not within the preset first frequency range, comparing and analyzing the frequency setting value with a preset second frequency range. analysis, the minimum threshold of the preset second frequency band range is equal to the maximum threshold of the preset first frequency band range; when the frequency setting value is within the preset second frequency band range, the first gating device and the second gating device are controlled to gating the mid-frequency band RF magnetic toroidal transformer; when the frequency setting value is not within the preset second frequency band range, a comparative analysis is performed based on the frequency setting value and the preset third frequency band range, the minimum threshold of the preset third frequency band range is equal to the maximum threshold of the preset second frequency band range; when the frequency setting value is within the preset third frequency band range, the first gating device and the second gating device are controlled to gating the high-frequency band RF magnetic toroidal transformer.

[0013] In one embodiment, the step of obtaining the resonant frequency of the radio frequency transmission quadrupole power supply circuit at the minimum power consumption by adjusting the sine wave generating device and the feedback regulating device comprises: adjusting the sine wave generating device and the feedback regulating device, and collecting the current value of the amplifying device in real time; when the minimum current value of the amplifying device is obtained, reading the current frequency of the sine wave generating device, that is, the resonant frequency of the radio frequency transmission quadrupole power supply circuit at the minimum power consumption.

[0014] A radio frequency transmission quadrupole power supply device comprises the radio frequency transmission quadrupole power supply circuit mentioned above, wherein the control device is used to scan and obtain the resonance frequency with minimum power consumption according to the control method mentioned above.

[0015] In one embodiment, the RF transmission quadrupole power supply device also includes a chassis, the control device, the sine wave generating device and the feedback adjustment device are integrated on the same main control board, the amplifying device, the first gating device, the second gating device and a plurality of RF magnetic ring transformers are integrated on the same power amplifier board, and the main control board and the power amplifier board are pluggable in the chassis.

[0016] The above-mentioned radio frequency transmission quadrupole power supply circuit and its control method and power supply device, when starting to work, the control device first controls the sine wave generating device to generate a corresponding sine wave signal, and the sine wave signal and the signal fed back by the feedback regulating device are amplified by the amplifying device, and finally loaded to the radio frequency transmission quadrupole by the corresponding radio frequency magnetic ring transformer connected under the gating of the control device and the first gating device and the second gating device, so as to generate a radio frequency high voltage electric field at the radio frequency transmission quadrupole. The above scheme is provided with a plurality of different radio frequency magnetic ring transformers. When ions of different mass ranges and different mass numbers are transmitted, different radio frequency magnetic ring transformers can be correspondingly selected by the first gating device and the second gating device, so that ion transmission of a very wide mass range from low mass number ions to high mass number ions can be realized, and a radio frequency high voltage electric field with flexible matching of different frequency bands can be generated, so as to achieve a good wide mass range ion transmission efficiency and instrument sensitivity; at the same time, a closed-loop control architecture is realized by the feedback regulating device, so that the radio frequency transmission quadrupole power supply circuit has a very high adaptability and stability, so that the application range of the mass spectrometer can be greatly improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the conventional technology, the drawings required for use in the embodiments or the conventional technology descriptions are briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0018] Figure 1 This is a schematic diagram of the structure of a radio frequency transmission quadrupole power supply circuit in one embodiment;

[0019] Figure 2 It is a schematic diagram of the structure of a radio frequency transmission quadrupole power supply circuit in another embodiment;

[0020] Figure 3 This is a partial structural schematic diagram of an amplifying device in an embodiment;

[0021] Figure 4 1. It is a flow chart of a control method of a radio frequency transmission quadrupole power supply circuit in one embodiment;

[0022] Figure 5 It is a schematic flow chart of a control method of a radio frequency transmission quadrupole power supply circuit in another embodiment;

[0023] Figure 6 A schematic diagram of a gating control flow in an embodiment;

[0024] Figure 7 A schematic diagram of a resonant frequency scanning process in an embodiment;

[0025] Figure 8 Schematic diagram of the structure of a radio frequency transmission quadrupole power supply device in one embodiment. DETAILED DESCRIPTION

[0026] In order to facilitate the understanding of the present application, the present application will be described more fully below with reference to the relevant drawings. The preferred embodiments of the present application are provided in the drawings. However, the present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present application more thorough and comprehensive.

[0027] See also Figure 1 A radio frequency transmission quadrupole power supply circuit comprises: a control device 10, a sine wave generating device 20, an amplifying device 30, a first gating device 40, a second gating device 60, a plurality of radio frequency magnetic ring transformers 50, a radio frequency transmission quadrupole 70 and a feedback regulating device 80, wherein the control device 10 is connected to the sine wave generating device 20, the sine wave generating device 20 is connected to the amplifying device 30, the amplifying device 30 is connected to the first gating device 40, the primary side of each radio frequency magnetic ring transformer 50 is respectively connected to the first gating device 40, the secondary side of each radio frequency magnetic ring transformer 50 is respectively connected to the second gating device 60, the second gating device 60 is connected to the radio frequency transmission quadrupole 70, the radio frequency transmission quadrupole 70 is connected to the feedback regulating device 80, the feedback regulating device 80 is connected to the control device 10, the feedback regulating device 80 is connected to the amplifying device 30, the amplifying device 30, the first gating device 40, the secondary side taps (not shown) of each radio frequency magnetic ring transformer 50 and the second gating device 60 are respectively connected to the control device 10.

[0028] Specifically, the sine wave generator 20 is also a DDS sine wave signal generator. Under the action of the control device 10, the sine wave generator 20 can generate sine wave signals of different frequency magnitudes. In one embodiment, according to the working requirements of the time-of-flight mass spectrometer using the RF transmission quadrupole 70, the sine wave generator 20 can specifically generate sine wave signals of three different frequency bands: high frequency band, medium frequency band and low frequency band. At the same time, in the RF transmission quadrupole power supply circuit of this embodiment, a plurality of RF magnetic ring transformers 50 with different frequency bands are provided. Under the action of the control device 10 and the first gating device 40, the primary access circuit of the RF magnetic ring transformer 50 corresponding to the required frequency band can be selected. At the same time, under the action of the control device 10 and the second gating device 60, the secondary access circuit of the RF magnetic ring transformer 50 corresponding to the required frequency band can be enabled. Thus, one of the RF transmission quadrupole power supply circuits is selected to access the circuit to work to meet the needs of ions in different mass ranges, thereby realizing ion transmission from a low mass number within 20 to a high mass number above 4500.

[0029] At the same time, the scheme of this embodiment adopts an amplitude closed-loop feedback control loop in hardware. The output waveform of the RF transmission quadrupole 70 can be collected in real time through the feedback adjustment device 80 for feedback adjustment. When the amplitude of the RF high voltage applied to the RF transmission quadrupole fluctuates, it will be compensated by feedback, so that the amplitude of the RF high voltage applied to the RF transmission quadrupole is guaranteed to be continuous and stable without interference, and the amplitude stability is within 0.1%, forming a stable and constant RF electric field. The secondary taps of each RF magnetic toroidal transformer 50 are respectively connected to the control device 10, so that the control device 10 can generate a DC bias voltage and add it to the middle tap end of the secondary side of the RF magnetic toroidal transformer 50 coil, thereby providing a DC bias reference voltage for the RF AC high voltage generated by the secondary side coil of the RF magnetic toroidal transformer 50.

[0030] It should be noted that the specific types of the first gating device 40 and the second gating device 60 are not unique, and the purpose is to enable different radio frequency toroidal transformers 50 to be connected to the circuit under the control of the control device 10. For example, in one embodiment, the first gating device 40 and the second gating device 60 can both be implemented by relays, wherein the first gating device 40 can be specifically a power relay, and the second gating device 60 can be specifically a high-voltage relay.

[0031] See also Figure 2 In one embodiment, the amplifier device 30 includes a variable gain amplifier programmable modulator 31, a common-phase multi-stage amplifier circuit 32 and an inverting multi-stage amplifier circuit 33. The variable gain amplifier programmable modulator 31 is connected to the sine wave generating device 20 and the feedback regulating device 80. The common-phase multi-stage amplifier circuit 32 and the inverting multi-stage amplifier circuit 33 are respectively connected to the variable gain amplifier programmable modulator 31. The common-phase multi-stage amplifier circuit 32 and the inverting multi-stage amplifier circuit 33 are respectively connected to the first selection device 40. The common-phase multi-stage amplifier circuit 32 and the inverting multi-stage amplifier circuit 33 are respectively connected to the control device 10.

[0032] Specifically, the variable gain amplifier programmable amplitude modulator 31 can perform amplitude modulation, which is connected to the sine wave generator 20 and the feedback adjustment device 80, and can receive the sine carrier signal of the sine wave generator 20 and the feedback signal fed back by the feedback adjustment device 80 for modulation. The modulated amplitude modulated wave is divided into two paths, and the phase difference of the two sine wave signals is 180°. One path is amplified by the same phase multi-stage amplifier circuit 32, and the other path is amplified by the anti-phase multi-stage amplifier circuit 33. After that, the controller controls the first gating device 40 to perform the gating function, selects a corresponding RF magnetic toroidal transformer 50 from the multiple RF magnetic toroidal transformers 50 to access the circuit, so that the two amplified sine wave signals with a phase difference of 180° are respectively input from the two ends of the primary side coil of the RF magnetic toroidal transformer 50, pass through the two ends of the secondary coil (that is, the secondary winding) of the RF magnetic toroidal transformer 50 and the second gating device 60, and finally loaded to the RF transmission quadrupole 70.

[0033] It can be understood that in order to ensure that the RF transmission quadrupole 70 can generate a RF high voltage electric field, the two sinusoidal wave signals output after passing through the second selection device 60 are respectively loaded on any two adjacent rods (the first group of adjacent rods) of the RF transmission quadrupole 70, and the two groups of adjacent rods of the RF transmission quadrupole 70 are connected and turned on, and the two sinusoidal wave signals can be output respectively through another group of adjacent rods. The solution of this embodiment adopts a multi-stage power amplifier circuit architecture for ions of different frequency bands and different mass ranges, and has a very high RF high voltage amplitude driving capability.

[0034] It should be noted that the specific structures of the in-phase multi-stage amplifier circuit 32 and the inverting multi-stage amplifier circuit 33 are not unique. In one embodiment, please refer to Figure 2 The in-phase multi-stage amplifier circuit 32 includes a in-phase amplifier 321, a first-stage power amplifier 322 and a second-stage power amplifier 323, the in-phase amplifier 321 is connected to the variable gain amplifier programmable modulator 31, the in-phase amplifier 321 is connected to the first-stage power amplifier 322, the first-stage power amplifier 322 is connected to the second-stage power amplifier 323, the second-stage power amplifier 323 is connected to the first selection device 40, the in-phase amplifier 321, the first-stage power amplifier 322 and the second-stage power amplifier 323 are respectively connected to the control device 10; and / or, the inverting multi-stage amplifier circuit 33 includes an inverting amplifier 331, a first-stage amplifier 332 and a second-stage amplifier 333, the inverting amplifier 331 is connected to the variable gain amplifier programmable modulator 31, the inverting amplifier 331 is connected to the first-stage amplifier 332, the first-stage amplifier 332 is connected to the second-stage amplifier 333, the second-stage amplifier 333 is connected to the first selection device 40, and the inverting amplifier 331, the first-stage amplifier 332 and the second-stage amplifier 333 are respectively connected to the control device 10.

[0035] Specifically, the scheme of this embodiment is that the two sinusoidal wave signals output by the variable gain amplifier programmable modulator 31, one of which is amplified by the in-phase amplifier 321, the first stage power amplifier 322, and the second stage power amplifier 323 to output the in-phase power amplified sinusoidal wave, and the other is amplified by the inverting amplifier 331, the first stage amplifier 332, and the second stage amplifier 333 to output the inverted power amplified sinusoidal wave, and the two sinusoidal waves have a phase difference of 180°. After being selected by the power relay (i.e., the first selection device 40), they are loaded to the two ends of the primary side coil of the corresponding conductive RF magnetic toroidal transformer 50, and after the turns ratio of the RF magnetic toroidal transformer 50 is increased, the two ends of the secondary side coil of the RF magnetic toroidal transformer 50 output two RF high-voltage sinusoidal waves with a phase difference of 180°, and after being selected by the high-voltage relay (i.e., the second selection device 60), they are added to the two adjacent rods of the RF transmission quadrupole to form a RF high-voltage electric field, and the two groups of pairs of rods of the RF transmission quadrupole are connected and turned on, and the other group of adjacent rods output two RF high-voltage sinusoidal waves.

[0036] The specific structures of the first stage power amplifier 322, the second stage power amplifier 323, the first stage amplifier 332 and the second stage amplifier 333 are not unique. In one embodiment, please refer to Figure 3The first-stage power amplifier 322 includes a first amplifier K1, a first resistor R1, a second resistor R2 and a third resistor R3, the second-stage power amplifier 323 includes a first switch tube Q1 and a second switch tube Q2, the first-stage amplifier 332 includes a second amplifier K2, a fourth resistor R4, a fifth resistor R5 and a sixth resistor R6, and the second-stage amplifier 333 includes a third switch tube Q3 and a fourth switch tube Q4; one end of the first resistor R1 is connected to the positive input end of the first amplifier K1, the other end of the first resistor R1 is connected to the in-phase amplifier 321, the reverse input end of the first amplifier K1 is connected to one end of the second resistor R2 and one end of the third resistor R3, the other end of the second resistor R2 is grounded, and the other end of the third resistor R3 is connected to the output end of the first amplifier K1, the control end of the first switch tube Q1 and the control end of the second switch tube Q2 , a first end of the first switch tube Q1 is connected to a power supply, a second end of the first switch tube Q1 is connected to a first end of the second switch tube Q2 and a first selection device 40 (not shown), and a second end of the second switch tube Q2 is connected to a power supply; one end of the fourth resistor R4 is connected to a positive input end of the second amplifier K2, the other end of the fourth resistor R4 is connected to an inverting amplifier 331, a negative input end of the second amplifier K2 is connected to one end of a fifth resistor R5 and one end of a sixth resistor R6, the other end of the fifth resistor R5 is grounded, the other end of the sixth resistor R6 is connected to an output end of the second amplifier K2, a control end of the third switch tube Q3 and a control end of the fourth switch tube Q4, a first end of the third switch tube Q3 is connected to a power supply, a second end of the third switch tube Q3 is connected to a first end of the fourth switch tube Q4 and the first selection device 40, and a second end of the fourth switch tube Q4 is connected to a power supply.

[0037] Specifically, the sine wave in-phase signal VIN1 output by the in-phase amplifier 321 and the sine wave inverted signal VIN2 output by the inverted amplifier 331 are respectively amplified by the first stage high-speed power amplifier (i.e., the first amplifier K1 and the second amplifier K2) in the same proportion, and enter the dual-power common-collector triode complementary push-pull power amplifier circuit in the second stage power amplifier 323 and the second stage amplifier 333 respectively, and output the in-phase and inverted two-way sine wave power signals with good current driving and voltage driving capabilities, and are added to the two ends of the primary side of the corresponding RF magnetic ring transformer 50 after being selected. The RF magnetic ring used can have extremely low loss and boost magnification at the resonance point of the RF frequency band. After the first-stage power amplifier, the second-stage power amplifier and the dedicated RF magnetic ring transformer 50, the secondary side of the RF magnetic ring transformer 50 coil can output a high-amplitude RF high voltage, which well meets the RF high voltage requirements of ions with different mass numbers in different frequency bands.

[0038] It should be noted that, in one embodiment, the RF magnetic toroidal transformer 50 uses a transformer coil made of a special material to ensure the working reliability of the RF magnetic toroidal transformer 50 , and specifically, the material may be a carbonyl iron powder core material.

[0039] See also Figure 2 In one embodiment, the control device 10 includes a main controller 11, a power supply and current monitor 12, a gating controller 13 and a medium and low voltage generator 14. The main controller 11 is connected to a sine wave generating device 20, a feedback regulating device 80 is connected to the main controller 11, the power supply and current monitor 12, the gating controller 13 and the medium and low voltage generator 14 are respectively connected to the main controller 11, the power supply and current monitor 12 is connected to an amplifying device 30, the gating controller 13 is connected to a first gating device 40 and a second gating device 60, and the medium and low voltage generator 14 is connected to the secondary side taps of each radio frequency magnetic ring transformer 50.

[0040] Specifically, the control device 10 includes a main controller 11 for realizing the main control function, a power supply and current monitor 12 for monitoring the power supply and current of the amplifier 30, a gate controller 13 for controlling the first gate device 40 and the second gate device 60 to operate in the corresponding channel, and a medium and low voltage generator 14 for providing a DC bias voltage to the tap of the secondary coil of each radio frequency magnetic ring transformer 50. When the radio frequency transmission quadrupole power supply circuit is turned on and operated, the main controller 11 sends a control instruction to the gate controller 13, so that the gate controller 13 controls the first gate device 40 and the second gate device 60 to also operate in the corresponding channel, so that the corresponding radio frequency magnetic ring transformer 50 is connected to the circuit; at the same time, the medium and low voltage generator 14 is controlled to provide a DC bias current to the secondary coil of the radio frequency magnetic ring transformer 50, and finally a high voltage electric field is generated at the radio frequency transmission quadrupole 70, and the current flowing through the amplifier 30 can be collected by the power supply and current monitor 12, so as to quickly and accurately scan the resonance frequency of the radio frequency transmission quadrupole power supply circuit with the minimum power consumption.

[0041] See also Figure 2 In one embodiment, the feedback adjustment device 80 includes a detection circuit 81, an amplitude monitor 84, a digital-to-analog controller 82 and a proportional-integral regulator 83. The detection circuit 81 is connected to the RF transmission quadrupole 70, the detection circuit 81 is connected to the proportional-integral regulator 83 and the amplitude monitor 84, the amplitude monitor 84 and the digital-to-analog controller 82 are respectively connected to the control device 10, the digital-to-analog controller 82 is connected to the proportional-integral regulator 83, and the proportional-integral regulator 83 is connected to the amplification device 30.

[0042] Specifically, after the two-way RF high-voltage sine wave output by the RF transmission quadrupole 70 is collected and analyzed by the detection circuit 81, the output feedback signal is added to the proportional integral regulator 83 (PI regulator), and together with the control signal generated by the main controller 11 through DA control (that is, the digital-to-analog controller 82), the error is compared and amplified through PI regulation to form a hardware closed-loop negative feedback, and finally the signal output by the PI regulator is fed back to the amplifier 30, and the amplitude of the RF high-voltage sine wave is compensated and controlled in real time to ensure the stability and constancy of the amplitude. At the same time, the feedback signal output by the detection circuit 81 is also returned to the main controller 11 through the amplitude monitor 84 for real-time amplitude monitoring, thereby forming a complete hardware closed-loop feedback control loop.

[0043] When the above-mentioned RF transmission quadrupole power supply circuit starts working, the control device 10 first controls the sine wave generating device 20 to generate a corresponding sine wave signal. The sine wave signal and the signal fed back by the feedback regulating device 80 are amplified by the amplifying device 30, and finally the corresponding RF magnetic ring transformer 50 connected under the control device 10 and the first gating device 40 and the second gating device 60 is loaded to the RF transmission quadrupole 70, thereby generating a RF high voltage electric field at the RF transmission quadrupole 70. The above scheme is provided with a plurality of different RF magnetic ring transformers 50. When ions of different mass ranges and different mass numbers are transmitted, different RF magnetic ring transformers 50 can be correspondingly selected through the first selection device 40 and the second selection device 60. Therefore, ion transmission of a very wide mass range from low mass number ions to high mass number ions can be achieved, and a RF high-voltage electric field with flexible matching of different frequency bands can be generated, thereby achieving good wide mass range ion transmission efficiency and instrument sensitivity. At the same time, a closed-loop control architecture is realized through the feedback adjustment device 80, so that the RF transmission quadrupole power supply circuit has extremely high adaptability and stability, thereby greatly improving the application range of the mass spectrometer.

[0044] See also Figure 4 , a control method for the radio frequency transmission quadrupole power supply circuit as described above, comprising step S100, step S200 and step S300.

[0045] Step S100, obtaining a frequency setting value; Step S200, controlling a first selection device and a second selection device to select a corresponding radio frequency magnetic ring transformer according to the frequency setting value; Step S300, obtaining a resonant frequency at which the radio frequency transmission quadrupole power supply circuit has minimum power consumption by adjusting a sine wave generating device and a feedback regulating device.

[0046] Specifically, the specific structure of the RF transmission quadrupole power supply circuit is as shown in the above-mentioned embodiments and drawings. When the RF transmission quadrupole power supply circuit provided by the present application is turned on, it adopts a frequency scanning program algorithm with fine steps in a wide frequency range. In different frequency bands, for RF transmission quadrupoles with different equivalent capacitances, and the inductor coil on the secondary side of the matching RF magnetic ring transformer 50, the resonant frequency with minimum power consumption can be quickly and accurately scanned with one key. First, the control device 10 obtains a frequency setting value, which can be directly input by the user into the control device 10, or sent by a host computer or user terminal connected to the control device 10.

[0047] Afterwards, the control device 10 controls the first selection device 40 and the second selection device 60 to select different RF magnetic ring transformers 50 according to the size of the received set frequency, and continuously adjusts the input of the amplifying device 30 to finally scan and obtain the resonant frequency with minimum power consumption, so that the RF transmission quadrupole power supply circuit has good adaptability.

[0048] The scanning method to obtain the resonant frequency is not the only one. Figure 5 In one embodiment, step S300 includes step S310 and step S320.

[0049] Step S310, adjust the sine wave generating device and the feedback regulating device, and collect the current value of the amplifying device in real time; Step S320, when the minimum current value of the amplifying device is obtained, read the current frequency of the sine wave generating device, which is the resonant frequency when the RF transmission quadrupole power supply circuit has the minimum power consumption.

[0050] Specifically, when the control device 10 adjusts the sine wave generating device 20 and the feedback regulating device 80, the corresponding signal loaded to the amplifying device 30 will also change. At this time, the control device 10 analyzes the current signal collected and sent by the receiving power supply and the current monitor 12. When the minimum current signal is obtained, the frequency corresponding to the minimum current signal can be used as the resonant frequency.

[0051] See also Figure 6 In one embodiment, the RF magnetic toroidal transformer 50 includes a low-frequency band RF magnetic toroidal transformer 50, a mid-frequency band RF magnetic toroidal transformer 50, and a high-frequency band RF magnetic toroidal transformer 50, and step S200 includes step S210, step S220, step S230, step S240, step S250, and step S260.

[0052] Step S210, compare and analyze the frequency setting value with the preset first frequency band range; Step S220, when the frequency setting value is within the preset first frequency band range, control the first gating device and the second gating device to gate the low-frequency RF magnetic toroidal transformer; Step S230, when the frequency setting value is not within the preset first frequency band range, compare and analyze the frequency setting value with the preset second frequency band range; the minimum threshold of the preset second frequency band range is equal to the maximum threshold of the preset first frequency band range; Step S240, when the frequency setting value is within the preset second frequency band range, control the first gating device and the second gating device to gate the mid-frequency RF magnetic toroidal transformer; Step S250, when the frequency setting value is not within the preset second frequency band range, compare and analyze the frequency setting value with the preset third frequency band range; the minimum threshold of the preset third frequency band range is equal to the maximum threshold of the preset second frequency band range; Step S260, when the frequency setting value is within the preset third frequency band range, control the first gating device and the second gating device to gate the high-frequency RF magnetic toroidal transformer.

[0053] For details, please refer to Figure 7 , the RF transmission quadrupole power supply circuit is powered on to initialize the system. The control device 10 first reads the Freg set frequency value (i.e., the above-mentioned frequency set value) sent by the host computer, and starts to determine whether the set frequency value is within the preset first frequency band, that is, whether it is between the FS1 and FE1 frequencies. If the judgment result is yes, the gating channel 1 is turned on, the power relay (first gating device 40) and the high-voltage relay (second gating device 60) select the first path, and the low-frequency RF magnetic ring transformer 50 is turned on. After that, the output of the digital-to-analog controller 82 (DAC) in the feedback adjustment device 80 and the output of the DDS frequency (i.e., the sine wave generating device 20) can be adjusted by continuously and finely stepping, and the current signal is collected through the power supply of the control device 10 and the current monitor 12, and the minimum current value of the amplifying device 30 is cyclically searched. When the minimum current value is finally found, the current actual frequency value Freg is read. Determine whether the frequency value is within the preset first frequency band. If so, it means that a matching resonant frequency within the preset first frequency band has been found and the frequency scan ends. If not, it means that there is an error in the connection of the RF transmission quadrupole load and the program ends.

[0054] If the set frequency value is not within the preset first frequency range as a result of the judgment, then determine whether the set frequency value is within the preset second frequency range, that is, whether it is between FS2 and FE2 frequencies. If so, open the selection channel 2, the power relay and the high-voltage relay select the second path, the intermediate frequency band RF magnetic ring transformer 50 is turned on, and the output of the analog-to-digital controller 82 is adjusted and the DDS frequency output is adjusted by continuously and finely stepping, and the current signal is collected through the power supply of the control device 10 and the current monitor 12, and the minimum current value of the amplification device 30 is cyclically searched. When the minimum current value is finally found, the current actual frequency value Freg is read. Determine whether the frequency value is within the preset second frequency range. If so, it means that the matching resonant frequency within the preset second frequency range has been found, and the frequency scan is ended; if not, it means that there is an error in the connection of the RF transmission quadrupole load, and the program ends.

[0055] If the set frequency value is still not within the preset second frequency band, then determine whether the set frequency is within the preset third frequency band, that is, whether it is between FS3 and FE3 frequencies. If so, turn on the selection channel 3, the power relay and the high-voltage relay select the third path, the high-frequency band RF magnetic ring transformer 50 is turned on, and the DAC output and the DDS frequency output are adjusted by continuous fine stepping. The power supply of the control device 10 and the current monitor 12 are used to collect current signals, and the minimum current value of the amplification device 30 is cyclically searched. When the minimum current value is finally found, the current actual frequency value Freg is read. Determine whether the frequency value is within the preset third frequency band. If so, it means that the matching resonant frequency within the preset third frequency band has been found, and the frequency scan is ended; if not, it means that there is an error in the connection of the RF transmission quadrupole load, and the program ends, so that a fast and accurate resonant frequency scan is achieved at the moment of power-on.

[0056] It should be noted that the relationship between the preset first frequency range, the preset second frequency range and the preset third frequency range is FS1<FE1=FS2<FE2=FS3<FE3. In one embodiment, when the power supply of the control device 10 and the current signal acquisition of the current monitor 12 are used to cyclically search for the minimum current value of the amplifying device 30, the cyclic search may be performed for one minute, and the lowest current value within this minute is used as the minimum current value of the amplifying device 30, so as to achieve fast and accurate resonant frequency scanning.

[0057] The control method of the above-mentioned RF transmission quadrupole power supply circuit adopts a frequency scanning program algorithm with fine steps in a wide frequency range, and realizes flexible switching and gating of RF high voltage in three frequency bands of high, medium and low, and automatic, fast and accurate scanning of the resonant frequency for transmission quadrupoles with different capacitance characteristics.

[0058] A radio frequency transmission quadrupole power supply device comprises the radio frequency transmission quadrupole power supply circuit mentioned above, wherein the control device 10 is used to scan and obtain the resonance frequency with minimum power consumption according to the above control method.

[0059] Specifically, the specific structure of the RF transmission quadrupole power supply circuit is shown in the above-mentioned embodiments and drawings, and the sine wave generating device 20 is also a DDS sine wave signal generator. Under the action of the control device 10, the sine wave generating device 20 can generate sine wave signals of different frequency magnitudes. In one embodiment, according to the working requirements of the time-of-flight mass spectrometer using the RF transmission quadrupole 70, the sine wave generating device 20 can specifically generate sine wave signals of three different frequency bands: high frequency band, medium frequency band and low frequency band. At the same time, in the RF transmission quadrupole power supply circuit of this embodiment, a plurality of RF magnetic ring transformers 50 with different frequency bands are provided. Under the action of the control device 10 and the first gating device 40, the primary side access circuit of the RF magnetic ring transformer 50 corresponding to the required frequency band can be selected, and at the same time, under the action of the control device 10 and the second gating device 60, the secondary side access circuit of the RF magnetic ring transformer 50 corresponding to the required frequency band can be enabled. Thus, one of the RF transmission quadrupole power supply circuits is selected to access the circuit to work, so as to meet the needs of ions in different mass ranges, thereby realizing ion transmission from a low mass number within 20 to a high mass number above 4500.

[0060] At the same time, the scheme of this embodiment adopts an amplitude closed-loop feedback control loop in hardware. The output waveform of the RF transmission quadrupole 70 can be collected in real time through the feedback adjustment device 80 for feedback adjustment. When the amplitude of the RF high voltage applied to the RF transmission quadrupole fluctuates, it will be compensated by feedback, so that the amplitude of the RF high voltage applied to the RF transmission quadrupole is guaranteed to be continuous and stable without interference, and the amplitude stability is within 0.1%, forming a stable and constant RF electric field. The secondary taps of each RF magnetic toroidal transformer 50 are respectively connected to the control device 10, so that the control device 10 can generate a DC bias voltage and add it to the middle tap end of the secondary side of the RF magnetic toroidal transformer 50 coil, thereby providing a DC bias reference voltage for the RF AC high voltage generated by the secondary side coil of the RF magnetic toroidal transformer 50.

[0061] When the RF transmission quadrupole power supply circuit is turned on, a frequency scanning program algorithm with fine steps in a wide frequency range is adopted. In different frequency bands, for RF transmission quadrupoles with different equivalent capacitances and the inductor coil on the secondary side of the matching RF magnetic ring transformer 50, the resonant frequency with minimum power consumption can be quickly and accurately scanned with one key. First, the control device 10 obtains a frequency setting value, which can be directly input into the control device 10 by the user, or sent by a host computer or user terminal connected to the control device 10.

[0062] Afterwards, the control device 10 controls the first selection device 40 and the second selection device 60 to select different RF magnetic ring transformers 50 according to the size of the received set frequency, and continuously adjusts the input of the amplifying device 30 to finally scan and obtain the resonant frequency with minimum power consumption, so that the RF transmission quadrupole power supply circuit has good adaptability.

[0063] In one embodiment, the RF transmission quadrupole power supply device also includes a chassis, the control device 10, the sine wave generating device 20 and the feedback adjustment device 80 are integrated on the same main control board, the amplifying device 30, the first gating device 40, the second gating device 60 and multiple RF magnetic ring transformers 50 are integrated on the same power amplifier board, and the main control board and the power amplifier board are pluggable in the chassis.

[0064] Specifically, in this embodiment, there are multiple power amplifier boards. For ease of understanding, please refer to Figure 8 In a more detailed embodiment, the number of power amplifier boards is two for illustration, namely, the first power amplifier board 500 and the second power amplifier board 600. The two power amplifier boards are two boards with exactly the same structure and function, wherein the windings of the radio frequency magnetic ring transformer 50 are somewhat different, and different high-voltage electric fields are generated for different radio frequency transmission quadrupoles. The main control board 400, the first power amplifier board 500 and the second power amplifier board 600 can be quickly inserted and removed from the chassis 700. Among them, the main control board 400 communicates with the outside and provides control signals to the first power amplifier board 500 and the second power amplifier board 600. The first power amplifier board 500 provides a radio frequency high-voltage electric field to the first group of radio frequency transmission quadrupoles, and the second power amplifier board 600 provides a radio frequency high-voltage electric field to the second group of radio frequency transmission quadrupoles. According to different radio frequency transmission quadrupole requirements, the first power amplifier board 500 and the second power amplifier board 600 can achieve rapid customized design and arbitrary plug-in and pull-out replacement, and can be more conveniently maintained.

[0065] The above-mentioned RF transmission quadrupole power supply equipment adopts a plug-in module integrated mechanical structure, so that each functional module can be quickly customized, designed, maintained and replaced according to different RF transmission quadrupole requirements, and has strong operational convenience.

[0066] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0067] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be construed as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent application shall be subject to the attached claims.

Claims

1. A radio frequency transmission quadrupole power supply circuit, characterized in that: include: A control device, a sine wave generating device, an amplifying device, a first gating device, a second gating device, a plurality of radio frequency magnetic ring transformers, a radio frequency transmission quadrupole and a feedback regulating device, The control device is connected to the sine wave generating device, the sine wave generating device is connected to the amplifying device, the amplifying device is connected to the first gating device, the primary side of each RF magnetic toroidal transformer is respectively connected to the first gating device, the secondary side of each RF magnetic toroidal transformer is respectively connected to the second gating device, the second gating device is connected to the RF transmission quadrupole, the RF transmission quadrupole is connected to the feedback adjustment device, the feedback adjustment device is connected to the control device, the feedback adjustment device is connected to the amplifying device, the amplifying device, the first gating device, the secondary side taps of each RF magnetic toroidal transformer and the second gating device are respectively connected to the control device.

2. The radio frequency transmission quadrupole power supply circuit according to claim 1, characterized in that: The amplifying device includes a variable gain amplifier program-controlled amplitude modulator, a common-phase multi-stage amplifier circuit and an inverting multi-stage amplifier circuit. The variable gain amplifier program-controlled amplitude modulator is connected to the sine wave generating device and the feedback regulating device. The common-phase multi-stage amplifier circuit and the inverting multi-stage amplifier circuit are respectively connected to the variable gain amplifier program-controlled amplitude modulator. The common-phase multi-stage amplifier circuit and the inverting multi-stage amplifier circuit are respectively connected to the first selection device. The common-phase multi-stage amplifier circuit and the inverting multi-stage amplifier circuit are respectively connected to the control device.

3. The radio frequency transmission quadrupole power supply circuit according to claim 2, characterized in that: The in-phase multi-stage amplifier circuit comprises an in-phase amplifier, a first-stage power amplifier and a second-stage power amplifier, the in-phase amplifier is connected to a variable gain amplifier programmable modulator, the in-phase amplifier is connected to the first-stage power amplifier, the first-stage power amplifier is connected to the second-stage power amplifier, the second-stage power amplifier is connected to the first gating device, and the in-phase amplifier, the first-stage power amplifier and the second-stage power amplifier are respectively connected to the control device; and / or, The inverting multi-stage amplifier circuit includes an inverting amplifier, a first-stage amplifier and a second-stage amplifier. The inverting amplifier is connected to a variable gain amplifier programmable modulator. The inverting amplifier is connected to the first-stage amplifier. The first-stage amplifier is connected to the second-stage amplifier. The second-stage amplifier is connected to the first selection device. The inverting amplifier, the first-stage amplifier and the second-stage amplifier are respectively connected to the control device.

4. The radio frequency transmission quadrupole power supply circuit according to any one of claims 1 to 3, characterized in that: The control device includes a main controller, a power supply and current monitor, a gating controller and a medium and low voltage generator. The main controller is connected to the sine wave generating device, the feedback regulating device is connected to the main controller, the power supply and current monitor, the gating controller and the medium and low voltage generator are respectively connected to the main controller, the power supply and current monitor are connected to the amplifying device, the gating controller is connected to the first gating device and the second gating device, and the medium and low voltage generator is connected to the secondary side taps of each of the radio frequency magnetic ring transformers.

5. The radio frequency transmission quadrupole power supply circuit according to claim 4, characterized in that: The feedback adjustment device includes a detection circuit, an amplitude monitor, a digital-to-analog controller and a proportional-integral regulator. The detection circuit is connected to the radio frequency transmission quadrupole, the detection circuit is connected to the proportional-integral regulator and the amplitude monitor, the amplitude monitor and the digital-to-analog controller are respectively connected to the control device, the digital-to-analog controller is connected to the proportional-integral regulator, and the proportional-integral regulator is connected to the amplification device.

6. A control method for a radio frequency transmission quadrupole power supply circuit according to any one of claims 1 to 5, characterized in that: include: Get the frequency setting value; Control the first gating device and the second gating device to gating the corresponding radio frequency magnetic toroidal transformer according to the frequency setting value; By adjusting the sine wave generating device and the feedback regulating device, the resonant frequency of the radio frequency transmission quadrupole power supply circuit at minimum power consumption is obtained.

7. The control method according to claim 6, characterized in that: The radio frequency magnetic toroidal transformer includes a low frequency band radio frequency magnetic toroidal transformer, a medium frequency band radio frequency magnetic toroidal transformer and a high frequency band radio frequency magnetic toroidal transformer, and the step of controlling the first gating device and the second gating device to gating the corresponding radio frequency magnetic toroidal transformer according to the frequency setting value includes: Compare and analyze the frequency setting value with the preset first frequency range; When the frequency setting value is within the preset first frequency range, controlling the first gating device and the second gating device to gating the low-frequency radio frequency magnetic toroidal transformer; When the frequency setting value is not within the preset first frequency range, a comparison is performed between the frequency setting value and a preset second frequency range, and the minimum threshold of the preset second frequency range is equal to the maximum threshold of the preset first frequency range; When the frequency setting value is within the preset second frequency band, controlling the first gating device and the second gating device to gating the intermediate frequency band radio frequency magnetic toroidal transformer; When the frequency setting value is not within the preset second frequency range, a comparison is performed between the frequency setting value and a preset third frequency range, and the minimum threshold of the preset third frequency range is equal to the maximum threshold of the preset second frequency range; When the frequency setting value is within the preset third frequency band, the first gating device and the second gating device are controlled to gating the high frequency band radio frequency magnetic toroidal transformer.

8. The control method according to claim 6, characterized in that: The step of obtaining the resonant frequency of the radio frequency transmission quadrupole power supply circuit at minimum power consumption by adjusting the sine wave generating device and the feedback regulating device comprises: Adjusting the sine wave generating device and the feedback regulating device, and collecting the current value of the amplifying device in real time; When the minimum current value of the amplifying device is obtained, the current frequency of the sine wave generating device is read, which is the resonant frequency when the radio frequency transmission quadrupole power supply circuit has the minimum power consumption.

9. A radio frequency transmission quadrupole power supply device, characterized in that: It comprises the radio frequency transmission quadrupole power supply circuit according to any one of claims 1 to 5, and the control device is used to scan and obtain the resonant frequency with minimum power consumption according to the control method according to any one of claims 6 to 8.

10. The radio frequency transmission quadrupole power supply device according to claim 9, characterized in that: It also includes a chassis, wherein the control device, the sine wave generating device and the feedback regulating device are integrated on the same main control board, the amplifying device, the first gating device, the second gating device and a plurality of radio frequency magnetic ring transformers are integrated on the same power amplifier board, and the main control board and the power amplifier board are pluggable in the chassis.

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