A sampling device

Abstract

The present invention provides a sampling structure and a sampling device. The sampling structure includes: a sampling head, wherein one side surface of the sampling head is flat, and a sample storage portion is provided on one side surface of the sampling head. The sample storage portion is transparent, and the area on the side surface of the sampling head other than the sample storage portion is non-transparent; and a rod body, wherein the sampling head is provided at one end of the rod body. According to the sampling structure of the present invention, the sample storage portion is transparent, and the area on the side surface of the sampling head 10 other than the sample storage portion is non-transparent, which facilitates light to pass through the sample storage portion to detect the sample, avoids the influence of light transmission from the area other than the sample storage portion on the test results, increases the light contrast between the sample storage portion and the area other than the sample storage portion, and improves the test results. In addition, the sample storage portion can store samples, and after the one side surface of the sampling head is scraped flat with a scraper, the thickness of the sample secretion is evenly applied, reducing the squeezing of the sample and improving the accuracy of the test results.

Description

Technical Field

[0001] The present invention relates to the field of detection sampling, and in particular to a sampling device. Background Art

[0002] The female vaginal microbiome is a component of the human microbiome, comprised of the vaginal microbiome, endocrine regulatory system, vaginal anatomy, and local immune system. The vaginal microbiome clinical evaluation system assesses the vaginal microbiome from both a morphological and functional perspective. This includes information on the predominance, diversity, and density of the vaginal microbiome, pathogens (such as Trichomonas and fungi), Lactobacillus grading, white blood cell count, epithelial cells, and functional indicators (such as pH, sialidase, leukocyte esterase, glucuronidase, and acetylglucosaminidase). This vaginal microbiome clinical evaluation system enables accurate diagnosis of various gynecological infections, providing important laboratory diagnostic evidence and guiding effective clinical treatment.

[0003] Morphology is the most important evaluation metric in the vaginal microecological evaluation system. Currently, the common clinical procedure involves scraping secretions from the upper third of the vaginal wall with a dry cotton swab. The smear is then evenly smeared onto a clean glass slide, stained with Gram stain, and observed under an upright optical microscope. Clinical practice requires that the smear have an appropriate thickness, uniform bacterial spread, no cell stacking, uniform staining, and a clean background.

[0004] However, there is currently no standardized SOP for secretion sampling and smearing methods and procedures in clinical gynecological microecological examinations. Operator proficiency significantly impacts the quality of the final slides, primarily due to uneven secretion smear thickness, random smearing locations, uneven bacterial distribution, and the easy crushing of Trichomonas vaginosis, all of which can easily lead to inaccurate test results. Existing sampling structures also affect test results due to light transmission outside the sample storage area, which can affect test accuracy. Summary of the Invention

[0005] In view of this, the present invention provides a sampling structure and a sampling device to solve the problem that the light transmission in the area outside the sample storage area can easily affect the test results, resulting in reduced accuracy of the test results.

[0006] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0007] The sampling structure according to the first embodiment of the present invention includes:

[0008] A sampling head, one side surface of the sampling head is flat, a sample storage portion is provided on one side surface of the sampling head, the sample storage portion is transparent, and the area on one side surface of the sampling head except the sample storage portion is non-transparent; a rod body, the sampling head is provided at one end of the rod body.

[0009] Wherein, the sample storage portion includes at least one groove, the bottom wall of the groove is transparent, and the bottom wall of the groove is a horizontal plane parallel to one side surface of the sampling head.

[0010] Wherein, the sample storage portion includes a plurality of grooves, and the depths of at least two of the plurality of grooves are different.

[0011] Wherein, the depth of at least one of the grooves changes in a step-like manner or a linear gradient.

[0012] The sampling head and the groove are respectively square, and the groove extends along the length direction of the sampling head.

[0013] Wherein, the sampling head is detachably arranged at one end of the rod body.

[0014] Wherein, a hydrophilic layer is formed on the surface of the sample storage part.

[0015] Wherein, a hydrophilic layer is formed on the surface of the sample storage portion, and a hydrophobic layer is formed on the area other than the sample storage portion on one side surface of the sampling head.

[0016] Wherein, the other end of the rod body is provided with a handle.

[0017] Wherein, a slot extending along the circumference of the rod body is provided at a position adjacent to the sampling head on the rod body.

[0018] Wherein, the sample storage portion includes at least one groove, and a solution groove is provided on one side surface of the sampling head, and the solution groove is spaced apart from the groove.

[0019] The solution tank is arranged at one end of the sampling head away from the rod body, and / or the solution tank is arranged at one or both sides of the edge of the sampling head, and the height of the plane where the notch of the solution tank is located is lower than the height of the plane where the notch of the groove is located.

[0020] The notch of the solution tank is provided with a cover to open or close the solution tank, and the cover is transparent. The sampling device according to the second embodiment of the present invention comprises:

[0021] The sampling structure in the above embodiment;

[0022] A base, wherein the base is provided with a receiving groove with an opening on one side, at least one end of the receiving groove is penetrated, and a scraper is provided at the penetrated end of the receiving groove, and the two ends of the scraper are respectively connected to the edges of the opposite sides of the receiving groove to define an insertion port connected to the receiving groove, and the sampling head of the sampling structure can pass through the insertion port and be placed in the receiving groove.

[0023] Wherein, a side surface of the scraper blade facing the receiving groove is a plane.

[0024] The scraper blade's side surface facing the receiving groove is parallel to the bottom wall of the receiving groove, and the distance between the scraper blade's side surface facing the receiving groove and the bottom wall of the receiving groove is greater than or equal to the thickness of the sampling head.

[0025] Wherein, a slot extending along the circumference of the rod body is provided on the rod body adjacent to the sampling head. When the sampling head is placed in the receiving groove, the slot is located outside the receiving groove and adjacent to the base.

[0026] In which, the sample storage portion includes at least one groove, and a solution groove is provided on one side surface of the sampling head, and the solution groove is spaced apart from the groove; the solution groove is provided on an end of the sampling head away from the rod body, and / or the solution groove is provided on one side or both sides of the edge of the sampling head, and the height of the plane where the notch of the solution groove is located is lower than the height of the plane where the notch of the groove is located; a transparent cover is provided at a position corresponding to the solution groove on the base, and when the sampling head of the sampling structure is placed in the receiving groove, the cover can close the solution groove.

[0027] The beneficial effects of the above technical solution of the present invention are as follows:

[0028] According to the sampling structure of the present invention, the sample storage portion is transparent, and the area on one side surface of the sampling head 10 except the sample storage portion is non-transparent, which facilitates light to pass through the sample storage portion to detect the sample, avoids the influence of light transmission from the area outside the sample storage portion on the detection result, increases the light contrast between the sample storage portion and the area outside the sample storage portion, and improves the detection result; in addition, the sample storage portion can store samples, and after scraping the surface of one side of the sampling head with a scraper, the thickness of the sample secretion is evenly applied, reducing the squeezing of the sample and improving the accuracy of the detection result. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 A schematic structural diagram of a sampling structure according to an embodiment of the present invention;

[0030] Figure 2 A schematic diagram of a partial structure of a sampling structure according to an embodiment of the present invention;

[0031] Figure 3 A schematic structural diagram of a sampling device according to an embodiment of the present invention;

[0032] Figure 4 A schematic structural diagram of a base in a sampling device according to an embodiment of the present invention;

[0033] Figure 5 Another structural schematic diagram of the sampling structure according to an embodiment of the present invention;

[0034] Figure 6 FIG. 4 is another structural schematic diagram of a sampling device according to an embodiment of the present invention.

[0035] Attached photos

[0036] Sampling head 10; groove 11; solution tank 12;

[0037] Rod body 20; handle 21; notch 22;

[0038] Base 30; accommodating groove 31; insertion port 32; scraper 33; cover 34. DETAILED DESCRIPTION

[0039] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the described embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field are within the scope of protection of the present invention.

[0040] The sampling structure according to an embodiment of the present invention will be described in detail below with reference to the accompanying drawings.

[0041] like Figures 1 to 4 As shown, the sampling structure according to an embodiment of the present invention includes a sampling head 10 and a rod body 20 .

[0042] Specifically, one side surface of the sampling head 10 is flat, and a sample storage portion is provided on one side surface of the sampling head 10 . The sample storage portion is transparent, and the area on one side surface of the sampling head 10 except the sample storage portion is non-transparent. The sampling head 10 is provided at one end of the rod body 20 .

[0043] That is, the sampling structure is mainly composed of a sampling head 10 and a rod body 20, wherein one side surface of the sampling head 10 can be flat, and a sample storage portion is provided on one side surface of the sampling head 10, and the sample storage portion can be horizontal or grooved, such as Figure 2As shown, the sample reservoir can be transparent, and the area outside the sample reservoir on one side of the sampling head 10 can be opaque. This facilitates light transmission through the sample reservoir to detect the sample, preventing the influence of light transmission outside the sample reservoir on the detection results. This increases the light contrast between the sample reservoir and the area outside the sample reservoir, thereby improving the detection results. The sampling head 10 can be provided at one end of the rod body 20, which can be elongated to facilitate sampling.

[0044] In some embodiments, the sample storage portion on one side surface of the sampling head 10 may include at least one groove 11, for example, there may be three grooves 11, the bottom wall of the groove 11 may be transparent to facilitate detection through light, and the bottom wall of the groove 11 may be a horizontal plane parallel to the one side surface of the sampling head 10, that is, the bottom wall of the groove 11 is a horizontal plane, and the horizontal plane is parallel to the one side surface of the sampling head 10. The sampling head 10 is provided at one end of the rod body 20, and the sample is placed in the groove 11, so that after sampling, the scraper can be used to scrape one side surface of the sampling head 10 to make the thickness of the sample in the groove 11 uniform, and the sample can be smeared at a predetermined position, reducing the squeezing of the sample during smearing and improving the accuracy of the test results.

[0045] In some embodiments of the present invention, the sample storage portion on one side surface of the sampling head 10 may include multiple grooves 11, at least two of which have different depths. For example, there are three grooves 11, each with a different depth. After the sample in the grooves 11 is scraped flat, the thickness of the sample is the same as the depth of the grooves 11. The grooves 11 of different depths facilitate smearing of samples with different thickness requirements. Optionally, the depth of at least one groove 11 changes in a stepped or linear gradient, so that changes in sample thickness can be detected in a single groove 11.

[0046] In other embodiments of the present invention, the sampling head 10 and the groove 11 can be square, for example, both can be rectangular, and the groove 11 can extend along the length direction of the sampling head 10. There can be multiple grooves 11, and the multiple grooves 11 can be evenly spaced and distributed along the width direction of the sampling head 10.

[0047] Optionally, the sampling head 10 is detachably mounted on one end of the rod body 20. The sampling head 10 may be provided with a first connection portion, and one end of the rod body 20 may be provided with a second connection portion. The first connection portion and the second connection portion are detachably connected, so that the sampling head 10 and the rod body 20 can be separated for testing after sampling is completed, thereby avoiding the rod body 20 occupying space and being inconvenient for testing.

[0048] In some embodiments, a hydrophilic layer may be formed on the surface of the sample storage portion, which facilitates contact between the sample and the surface, avoids gaps or air between the sample and the surface, avoids the influence of gaps or air on the test results, and improves the accuracy of the test results.

[0049] Optionally, a hydrophilic layer may be formed on the surface of the sample reservoir, and a hydrophobic layer may be formed on one side surface of the sampling head 10 in an area other than the sample reservoir. The hydrophobic layer prevents sample from remaining in areas outside the sample reservoir, facilitating cleaning. For example, the inner sidewalls and bottom wall of the groove 11 may be formed with a hydrophilic layer to facilitate contact between the sample and the inner sidewalls and bottom wall of the groove 11, and to facilitate contact between the sample and the bottom wall, thereby facilitating uniform sample thickness.

[0050] Specifically, the other end of the rod body 20 can be provided with a handle 21, which can be square or round to facilitate sampling. The handle 21 can be provided with an anti-slip structure, which can be a convex or concave structure, or a non-slip material layer.

[0051] According to an embodiment of the present invention, a notch may be provided on the rod body 20 adjacent to the sampling head 10. The notch may extend along the circumference of the rod body 20, and may extend half a circumference along the circumference of the rod body 20, so as to facilitate separation of the sampling head 10 from the rod body 20 and avoid the rod body 20 occupying space during detection.

[0052] In some embodiments, the sample storage portion includes at least one groove 12, such as Figure 5 As shown, a solution tank 12 is provided on one side surface of the sampling head 10. There may be multiple solution tanks 12. The solution tanks 12 may extend along the width direction of the sampling head 10. The solution tanks 12 may be square, rectangular, circular, or other shapes. The solution tanks 12 are spaced apart from the grooves 11. In the process of observing Trichomonas and leukocytic poisoning particles, the sample needs to be observed in a solution. The solution may be physiological saline or a dye solution. The solution tank 12 can disperse the sample in the solution, making it easy to observe the smear sample and the solution-treated sample at the same time, which is simple and convenient. In order to prevent the liquid from flowing out of the solution tank 12, a retaining wall may be provided at the edge of the solution tank 12 to prevent the liquid from flowing out of the solution tank 12.

[0053] In other embodiments, the solution tank 12 may be provided at an end of the sampling head 10 away from the rod body 20, and / or the solution tank 12 may be provided at one or both edges of the sampling head 10, with the plane where the notch of the solution tank 12 is located being lower than the plane where the notch of the groove 11 is located, thereby preventing the liquid in the solution tank 12 from overflowing and entering the groove 11, thereby avoiding affecting the sample in the groove 11. In other words, the solution tank 12 may be provided at the top of the sampling head 10, away from the rod body 20, and / or the solution tank 12 may be provided at one or both edges of the sampling head 10, with the length direction of the solution tank 12 being parallel to the length direction of the groove 11, with the plane where the notch of the solution tank 12 is located being lower than the plane where the notch of the groove 11 is located, thereby preventing the liquid in the solution tank 12 from overflowing and entering the groove 11.

[0054] In an embodiment of the present invention, a cover is provided at the notch of the solution tank 12 to open or close the solution tank 12. The cover is transparent to prevent the liquid in the solution tank 12 from overflowing into the groove 11, and to prevent external impurities from entering the sample in the solution tank 12, thereby preventing the sample in the solution tank 12 from being affected. An embodiment of the present invention also provides a sampling device.

[0055] like Figure 3 and Figure 4 As shown, the sampling device according to an embodiment of the present invention includes the sampling structure and base of the above-mentioned embodiment, wherein a receiving groove 31 with an opening on one side is provided on the base 30, and at least one end of the receiving groove 31 is penetrated. A scraper 33 is provided at the penetrated end of the receiving groove 31. The two ends of the scraper 33 are respectively connected to the edges of the receiving groove 31 on opposite sides to define an insertion port 32 communicating with the receiving groove 31. The sampling head 10 of the sampling structure can be placed in the receiving groove 31 through the insertion port 32. The cooperation between the sampling structure and the base facilitates the scraping of the sample by the scraper to make the sample uniform. In addition, the sample storage portion is transparent, and the area on one side of the surface of the sampling head 10 other than the sample storage portion is non-transparent, which facilitates light to pass through the sample storage portion to detect the sample, thereby avoiding the influence of light transmission from the area outside the sample storage portion on the detection result, increasing the light contrast between the sample storage portion and the area outside the sample storage portion, and improving the detection result.

[0056] That is to say, in a specific embodiment, a receiving groove 31 with an open side can be provided on the base 30. There can be multiple receiving grooves 31, and the multiple receiving grooves 31 can be spaced apart along the length direction of the base 30. The receiving groove 31 can be square, and at least one end of the receiving groove 31 is penetrated. A scraper 33 can be provided at the penetrated end of the receiving groove 31. For example, one end of the receiving groove 31 is penetrated, and the other end is not penetrated. The scraper 33 can be provided on both side edges of the penetrated end of the receiving groove 31, and the two ends of the scraper 33 can be respectively connected to the edges of the opposite sides of the receiving groove 31 to define an insertion port 32 connected to the receiving groove 31. The sampling head 10 of the sampling structure can be placed in the receiving groove 31 through the insertion port 32. The side surface of the scraper 33 facing the receiving groove 31 is flat, and the side surface of the scraper 33 facing the receiving groove 31 can be parallel to the side surface of the sampling head 10, so that the scraper 33 can scrape the sample in the groove 11 on the sampling head 10 flat, so that the sample is evenly smeared. The side of the base 30 on which the receiving groove 31 is provided can be a plane. When the sampling head 10 is placed in the receiving groove 31 through the insertion port 32, the side surface of the sampling head 10 and the side surface of the base 30 on which the receiving groove 31 is provided can be parallel. The side surface of the sampling head 10 and the side surface of the base 30 on which the receiving groove 31 is provided can be in the same horizontal plane. The side surface of the sampling head 10 can also be higher or lower than the side surface of the base 30 on which the receiving groove 31 is provided, so that the sample can be applied more evenly.

[0057] Specifically, the side surface of the scraper 33 facing the receiving groove 31 can be parallel to the bottom wall of the receiving groove 31, and the distance between the side surface of the scraper 33 facing the receiving groove 31 and the bottom wall of the receiving groove 31 can be greater than or equal to the thickness of the sampling head 10. The specific distance can be selected according to the thickness of the sampling head 10, the depth of the groove 11 and the desired smear thickness of the sample.

[0058] In some embodiments of the present invention, a notch 22 extending along the circumference of the rod body 20 may be provided on the rod body 20 adjacent to the sampling head 10. When the sampling head 10 is placed in the receiving groove 31, the notch 22 is located outside the receiving groove 31 and adjacent to the base 30. The rod body 20 and the sampling head 10 are easily separated when passing through the notch 22. After the sampling is completed, the sampling head 10 can be placed in the receiving groove 31. During the process of inserting the sampling head 10 into the receiving groove 31, the sample has been evenly spread in the groove 11. In order to avoid the inconvenience of detection caused by the rod body 20 being too long, the rod body 20 can be broken or shortened through the notch 22, which is simple and easy.

[0059] In an embodiment of the present invention, the sample storage portion includes at least one groove 12, such as Figure 5 As shown, a solution tank 12 is provided on one side of the sampling head 10 in the sampling structure. The solution tank 12 is spaced apart from the groove 11. The solution tank 12 can be provided at the top of the sampling head 10 or at one or both sides of the edge of the sampling head 10. The length direction of the solution tank 12 can be parallel to the length direction of the groove 11. Figure 6 As shown, a transparent cover sheet 34 is provided on the base 30 at a position corresponding to the solution tank 12. When the sampling head 10 of the sampling structure is placed in the receiving tank 12, the cover sheet 34 can seal the solution tank 12. For example, when the solution tank 12 is provided at the top of the sampling head 10, the cover sheet 34 can be located at the top of the receiving tank 31. When the solution tank 12 is provided at one or both sides of the sampling head 10, the cover sheet 34 can be located at one or both sides of the receiving tank 31 at a position corresponding to the solution tank 12. This facilitates the cover sheet 34 to seal the solution tank 12 when the sampling head 10 of the sampling structure is placed in the receiving tank 12, preventing the liquid in the solution tank 12 from flowing out and preventing external impurities from entering the sample in the solution tank 12, thereby preventing the sample in the solution tank 12 from being affected.

[0060] Furthermore, the solution tank 12 is provided at one end of the sampling head 10 away from the rod body 20, or the solution tank 12 is provided at one side or both sides of the edge of the sampling head 10. The height of the plane where the notch of the solution tank 12 is located is lower than the height of the plane where the notch of the groove 11 is located. A transparent cover 34 is provided at a position corresponding to the solution tank 12 on the base 30 to facilitate observation of the liquid sample. When the sampling head 10 of the sampling structure is placed in the receiving groove 12, the cover 34 can seal the solution tank 12 to prevent the liquid in the solution tank 12 from flowing out and prevent external impurities from entering the sample in the solution tank 12. During actual application of the sampling device of the embodiment of the present invention, sampling can be first performed through the sampling head 10, so that the sample is stored in the groove 11 and the amount of sample is as much as possible outside the groove 11, and the sampling head 10 is inserted into the receiving groove 31. During the process of inserting the sampling head 10 into the receiving groove 31, the sample has been evenly spread in the groove 11, and the thickness of the sample is uniform. In order to avoid the inconvenience of detection caused by the rod body 20 being too long, at this time, the rod body 20 can be broken or shortened through the notch 22, and then the base 30 with the sample is placed under the detection instrument for detection.

[0061] Unless otherwise defined, the technical or scientific terms used in the present invention shall have the ordinary meaning understood by persons having ordinary skills in the field to which the present invention belongs. The words "first", "second" and similar words used in the present invention do not indicate any order, quantity or importance, but are only used to distinguish different components. Words such as "connect" or "connected" are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "Up", "down", "left", "right" and the like are only used to indicate relative positional relationships. When the absolute position of the object being described changes, the relative positional relationship also changes accordingly.

[0062] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A sampling device, characterized in that: including a sampling structure and a base; The sampling structure comprises: A sampling head, wherein one side surface of the sampling head is flat, a sample storage portion is provided on the one side surface of the sampling head, the sample storage portion is transparent, and an area on the one side surface of the sampling head other than the sample storage portion is non-transparent; A rod body, wherein the sampling head is arranged at one end of the rod body; The sample storage portion includes at least one groove, the bottom wall of which is a horizontal plane parallel to a side surface of the sampling head, and the depth of at least one of the grooves changes in a stepped or linear manner; a solution groove is provided on one side surface of the sampling head, the solution groove is spaced apart from the groove, and the solution groove extends along the width direction of the sampling head; The base is provided with a receiving groove with an opening on one side, and at least one end of the receiving groove is penetrated. A scraper is provided at the penetrated end of the receiving groove, and the two ends of the scraper are respectively connected to the edges of the opposite sides of the receiving groove to define an insertion port connected to the receiving groove. The sampling head of the sampling structure can pass through the insertion port and be placed in the receiving groove; the scraper is used to scrape the sample in the groove on the sampling head so that the sample is evenly spread.

2. The sampling device according to claim 1, characterized in that The bottom wall of the groove is transparent.

3. The sampling device according to claim 2, characterized in that The sample storage portion includes a plurality of grooves, and at least two of the grooves have different depths.

4. The sampling device according to claim 1, characterized in that The sampling head is detachably arranged at one end of the rod body.

5. The sampling device according to claim 1, characterized in that A hydrophilic layer is formed on the surface of the sample storage part.

6. The sampling device according to claim 1, characterized in that A hydrophilic layer is formed on the surface of the sample storage portion, and a hydrophobic layer is formed on a side surface of the sampling head except for the sample storage portion.

7. The sampling device according to claim 1, characterized in that A slot extending along the circumference of the rod body is provided on the rod body at a position adjacent to the sampling head.

8. The sampling device according to claim 7, characterized in that The solution tank is arranged at one end of the sampling head away from the rod body, and / or the solution tank is arranged at one or both sides of the edge of the sampling head, and the height of the plane where the notch of the solution tank is located is lower than the height of the plane where the notch of the groove is located.

9. The sampling device according to claim 7, characterized in that: A cover is provided at the notch of the solution tank to open or close the solution tank, and the cover is transparent.

10. The sampling device according to claim 1, characterized in that A surface of the scraper blade facing the receiving groove is a plane.

11. The sampling device according to claim 10, characterized in that A side surface of the scraper facing the receiving groove is parallel to the bottom wall of the receiving groove, and a distance between the side surface of the scraper facing the receiving groove and the bottom wall of the receiving groove is greater than or equal to the thickness of the sampling head.

12. The sampling device according to claim 1, characterized in that A slot extending along the circumference of the rod body is provided on the rod body adjacent to the sampling head. When the sampling head is placed in the receiving groove, the slot is located outside the receiving groove and adjacent to the base.

13. The sampling device according to claim 7 or 8, characterized in that: A transparent cover is provided on the base at a position corresponding to the solution tank. When the sampling head of the sampling structure is placed in the receiving tank, the cover can close the solution tank.

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