A radionuclide ion distribution system

Abstract

The present invention discloses a radioactive nuclide ion distribution system, including a stock liquid device, a multi-way valve, a waste liquid collection device, a dilution water device, an injection pump, a two-way valve, and a gas device. The multi-way valve is provided with a nuclide ion receiving port connected to the nuclide ion output end of the stock liquid device, a waste liquid discharge port connected to the waste liquid collection device, a dilution water receiving port connected to the dilution water device, an injection port connected to the two-way valve, and a plurality of nuclide ion sub-packaging ports. The injection pump is connected to the two-way valve, and the two-way valve is connected to the gas device. The present invention can dilute the nuclide ion stock solution in any proportion as needed to be sub-packaged for use in different synthesizers, thereby greatly saving resources. By setting the waste liquid collection device and the dilution water device, the multi-way valve and all pipelines can be cleaned to avoid residual nuclide ions therein causing inaccurate sub-packaging next time.

Description

Technical Field

[0001] The invention belongs to the technical field of medical experimental equipment, in particular to a radionuclide ion distribution system. Background Art

[0002] Radioactive labeled drugs obtained by labeling with radioactive nuclides are the most commonly used PET radiopharmaceuticals (also known as imaging agents) and have been widely used in PET imaging studies of tumors, cardiovascular diseases, and neuropsychiatric diseases, which has led to an increasing demand for radioactive nuclide ions and quantitative labeling. Radioactive nuclides such as 18F, 11C, and 13N are generally manufactured by cyclotrons, and then these radioactive nuclides are labeled on different chemical substrates through chemical synthesis modules (also known as synthesizers) to synthesize various radioactive drugs for clinical use. Since positron radioactive drugs have the characteristics of high radioactivity and short half-life, they are all fully automatically synthesized using trace reagents through chemical synthesis modules.

[0003] For example, 18F radionuclide, cyclotron 18 O(p,n) 18 F nuclear reaction, application of small volume [ 18 O]H 2 O target, and bombard the target with a certain proton beam continuously. - Transferred to the automated chemical synthesis module, 18F-F - It is adsorbed onto the QMA column and waits to be poured into the reaction tube for subsequent synthesis reaction. The automated synthesis module uses different target water volumes (H 2 18 O) is fixed, about 2-5 mL, while the radioactive nuclide 18F-F transmitted by the automated synthesis module - All of them have not been processed, and only one reaction can be carried out after each target transfer, making each 18F-F - Only one imaging agent can be synthesized, which results in great waste.

[0004] At present, most hospitals use new generation synthesis modules for the use of fluoride ions, which have the characteristics of high system integration, stable synthesis process, short production time, and significantly higher yield than earlier products. Therefore, most accelerator centers have the problem that the actual demand for nuclides is less than the maximum output of the equipment, or the accelerator needs to be turned on twice to synthesize two imaging agents on different synthesis modules. Both of these situations have caused a waste of resources. The biggest reason is that the accelerator transfers target water (H 2 18 O) are all transmitted at once, and it is impossible to separate the excess nuclides or distribute the target water to different synthesis modules for use.

[0005] Chinese patent document CN203568823U discloses an automated fluoride ion dispensing device, comprising a collecting bottle, a first control valve, a second control valve, a quantitative injection pump and a collecting and dispensing valve connected in sequence, wherein the collecting and dispensing valve is provided with a plurality of independently activatable passages along the axial direction, and the passages are respectively connected to corresponding dispensing bottles to realize the metered dispensing of fluoride ion solution.

[0006] However, the fluorine ion dispensing device disclosed in the above-mentioned Chinese patent document is provided with a plurality of control valves, which is complex in structure and inconvenient to control. In addition, the liquid remaining in the dispensing valve of the existing radionuclide ion dispensing device cannot be discharged after a dispensing operation, thereby affecting the accuracy of measurement. Summary of the invention

[0007] In view of the shortcomings of the prior art, the present invention aims to provide a radionuclide ion distribution system to solve the problems of complex structure and residual liquid affecting the measurement accuracy mentioned in the above background technology.

[0008] In order to solve the above technical problems, the technical solution provided by the present invention is:

[0009] A radioactive nuclide ion distribution system comprises a stock liquid device, a multi-way valve, a waste liquid collection device, a dilution water device, an injection pump, a two-way valve, and a gas device. The multi-way valve is provided with a nuclide ion receiving port connected to the nuclide ion output end of the stock liquid device, a waste liquid discharge port connected to the waste liquid collection device, a dilution water receiving port connected to the dilution water device, an injection port connected to the two-way valve, and a plurality of nuclide ion dispensing ports. The injection pump is connected to the two-way valve, and the two-way valve is connected to the gas device.

[0010] Adopting the above technical scheme, the nuclide ion receiving port, the dilution water receiving port and the injection port on the multi-way valve are opened, and the injection pump extracts the radioactive nuclide ion stock solution from the stock solution device through the two-way valve and the multi-way valve, extracts the dilution water from the dilution water device and extracts a certain amount of boosting air, then closes the nuclide ion receiving port, the dilution water receiving port and the injection port, opens any nuclide ion sub-packaging port, pushes the stock solution, dilution water and boosting air in the injection pump into the corresponding sub-packaging channel, and then opens the normally closed port of the two-way valve, so that the compressed gas in the gas device escapes and pushes the diluted stock solution, and transports the diluted stock solution to the synthesizer. After all the sub-packaging work is completed, the dilution water receiving port and the injection port can be opened at any time, so that the injection pump can extract dilution water to clean the multi-way valve and all the pipes connected to the multi-way valve in turn. The cleaning process is recommended to be carried out after the sub-packaging is completed. If cleaning is performed before sub-packaging, the stock solution device needs to be replaced after the cleaning is completed to prevent the cleaning waste liquid from entering the stock solution device. Preferably, the stock liquid device, the waste liquid collection device, and the dilution water device are preferably sealed containers to avoid contamination, such as vials with rubber stoppers.

[0011] Furthermore, the capacity of the stock liquid device is 10-30 ml, and the capacity of the waste liquid collection device is 1000 ml.

[0012] Furthermore, the nuclide ion dispensing port is connected to a synthesizer.

[0013] Furthermore, the number of the synthesizers is greater than or equal to three. That is, the transmission of at least three synthesizers is supported, that is, the multi-way valve is at least a six-way valve. The synthesizer is used to further synthesize the separated radionuclide ions into medicines.

[0014] Furthermore, the synthesizer is placed in a hot chamber, and an opening and closing safety interlocking device is provided between the hot chambers.

[0015] Furthermore, the opening and closing safety interlocking device is an alarm bell or a warning light. That is, after each dispensing, only one synthesizer is in operation, and the other synthesizers will be opened and the warning lights will light up or the alarm bells will sound.

[0016] Furthermore, a dosage calibrator is provided on the injection pump.

[0017] Furthermore, the maximum measurement value of the dose calibrator is 20 Ci, that is, the dose calibrator can measure a maximum of 20 Ci of radioactive nuclide ions.

[0018] Furthermore, a proportional regulating valve is provided between the two-way valve and the gas device to adjust the transmission gas pressure.

[0019] Furthermore, the nuclide ion input end of the stock solution device is connected to the cyclotron.

[0020] Furthermore, the valve cores of the multi-way valve and the two-way valve are both made of sapphire, which is corrosion-resistant and wear-resistant.

[0021] Furthermore, the power requirement of the radionuclide ion distribution system is a voltage of 110-220V, a power of 300W, and the system gas requirement is a gas pressure of at least 70Psi.

[0022] Furthermore, an activity meter and a liquid level sensor are provided in the raw liquid device, and the activity meter is used to measure the activity of the radioactive nuclide ions, and the liquid level sensor is used to measure the liquid height.

[0023] Furthermore, the gas device contains one of compressed air, nitrogen and argon, wherein nitrogen or argon is preferred, and the compressed air is filtered clean air.

[0024] Furthermore, it also includes a controller, the output ends of the controller are electrically connected to the nuclide ion receiving port, the waste liquid discharge port, the dilution water receiving port, the injection port and several nuclide ion filling ports on the multi-way valve, the injection pump, the two-way valve, the gas device, the raw liquid device, the waste liquid collection device, and the dilution water device, and the input ends of the controller are electrically connected to the activity meter, the liquid level sensor, the safety interlock device, the dose calibrator, and the proportional control valve.

[0025] The present invention has the following beneficial effects:

[0026] 1. The present invention can dilute the stock solution in any proportion according to the needs through the arrangement of the stock solution device and the dilution water device so as to be packaged for use in different synthesizers, thereby greatly saving resources and improving the utilization efficiency of nuclide ions.

[0027] 2. The present invention can clean the multi-way valve and all pipelines through the arrangement of the waste liquid collection device and the dilution water device, avoiding the cumbersome and error-prone operation of manual cleaning, ensuring the cleanliness and hygiene of the transmission pipeline, and avoiding the residual nuclide ions causing inaccurate packaging next time. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 This is a schematic diagram of the principle of a radionuclide ion distribution system in Example 1;

[0029] Figure 2 This is a schematic diagram of the connection of a radionuclide ion distribution system controller in Example 2;

[0030] Figure 3 This is a schematic diagram of the structure of a radionuclide ion distribution system in Example 3;

[0031] Figure 4This is a schematic diagram of the internal structure of Example 3.

[0032] In the figure: 1. stock solution device; 2. multi-way valve; 201. nuclide ion receiving port; 202. waste liquid discharge port; 203. dilution water receiving port; 204. injection port; 205. nuclide ion dispensing port; 3. waste liquid collection device; 4. dilution water device; 5. injection pump; 6. two-way valve; 7. gas device; 8. synthesizer; 9. cyclotron; 10. hot chamber; 11. safety interlock device; 12. dose calibrator; 13. ratio adjustment Valve; 14. Slot-type photoelectric switch infrared sensor; 15. Controller; 16. Activity meter; 17. Liquid level sensor; 18. Box; 19. Top plate; 20. Syringe bracket; 21. Upper pressure plate; 22. Pressure plate; 23. Stepper motor mounting plate; 24. Placement plate; 25. Hook; 26. Conduit; 27. Through slot; 28. Screw; 29. ​​Stepper motor; 30. Screw mounting block; 31. Guide rail; 32. Slider; 33. Sensor mounting adjustment plate. DETAILED DESCRIPTION

[0033] The present invention is described in detail below with reference to the accompanying drawings and embodiments.

[0034] Example 1

[0035] A radionuclide ion distribution system, such as Figure 1 As shown, it includes a stock liquid device 1, a multi-way valve 2, a waste liquid collection device 3, a dilution water device 4, an injection pump 5, a two-way valve 6, and a gas device 7. The multi-way valve 2 is provided with a nuclide ion receiving port 201 connected to the nuclide ion output end of the stock liquid device 1, a waste liquid discharge port 202 connected to the waste liquid collection device 3, a dilution water receiving port 203 connected to the dilution water device 4, an injection port 204 connected to the two-way valve 6, and three nuclide ion dispensing ports 205. The injection pump 5 is connected to the two-way valve 6, and the two-way valve 6 is connected to the gas device 7 through a proportional regulating valve 13. The gas device 7 contains compressed argon. The nuclide ion dispensing port 205 is connected to the synthesizer 8. There are three synthesizers 8, and the multi-way valve 2 is a six-way valve. The synthesizer 8 is placed in a hot chamber 10, and an opening and closing safety interlocking device 11 is provided between the hot chambers 10. The opening and closing safety interlocking device 11 is an alarm bell or a warning light. The injection pump 5 is provided with a dose calibrator 12, and the maximum measurement value of the dose calibrator 12 is 20 Ci. The nuclide ion input end of the stock solution device 1 is connected to the cyclotron 9. The valve cores of the multi-way valve 2 and the two-way valve 6 are both made of sapphire.

[0036] When working, the nuclide ion receiving port 201, the dilution water receiving port 203 and the injection port 204 on the multi-way valve 2 are opened, and the injection pump 5 extracts the stock liquid from the stock liquid device 1, the dilution water from the dilution water device 4 and a certain amount of boosting air through the two-way valve 6 and the multi-way valve 2 in sequence, and then closes the nuclide ion receiving port 201, the dilution water receiving port 203 and the injection port 204, opens any nuclide ion dispensing port 205, pushes the stock liquid, dilution water and boosting air in the injection pump 5 into the corresponding dispensing channel, and then opens the normally closed port of the two-way valve 6, so that the compressed argon gas in the gas device 7 is released through the proportional regulating valve 13 to push the dilution stock liquid for transmission, and the dilution stock liquid is sent to the synthesizer 8. The use of boosting air can ensure that there is no liquid residue in the injection pump 5 after pushing the dilution liquid, and the dispensing dosage is accurately controlled. The boosting air can be obtained from the waste liquid discharge port 202 connected to the waste liquid collection device 3. After all subpackaging is completed and the synthesizer 8 has finished working and has transferred the finished drug to the subpackaging hot chamber, the dilution water receiving port 203 and the injection port 204 are opened, so that the injection pump 5 can extract dilution water to clean the multi-way valve 2 and all pipelines connected to the multi-way valve 2, and finally the dilution water receiving port 203 is closed, and the waste liquid discharge port 202 is opened, so that the injection pump 5 can push the cleaning waste liquid to the waste liquid collection device 3. It is recommended that the cleaning process be performed after the subpackaging is completed. If cleaning is performed before subpackaging, the stock liquid device 1 needs to be replaced after the cleaning is completed.

[0037] Example 2

[0038] A radioactive nuclide ion distribution system, which differs from Example 1 in that an activity meter 16 and a liquid level sensor 17 are provided in a stock liquid device 1, a multi-way valve 2 is an eight-way valve, and the multi-way valve 2 has four nuclide ion dispensing ports 205, which are respectively connected to a synthesizer 8. A two-way valve 6 is directly connected to a gas device 7, and compressed nitrogen is contained in the gas device 7. A controller 15 is also included, such as Figure 2 As shown, the output ends of the controller 15 are electrically connected to the nuclide ion receiving port 201, the waste liquid discharge port 202, the dilution water receiving port 203, the injection port 204 and the four nuclide ion filling ports 205, the injection pump 5, the two-way valve 6, the gas device 7, the raw liquid device 1, the waste liquid collection device 3, and the dilution water device 4 on the multi-way valve 2, and the input ends of the controller 15 are electrically connected to the activity meter 16, the liquid level sensor 17, the safety interlocking device 11, and the dose calibrator 12.

[0039] The activity meter 16, the liquid level sensor 17, the safety interlock device 11, and the dosage calibrator 12 can respectively transmit the signals they obtain to the controller 15. The controller 15 transmits instructions to each port on the multi-way valve 2, the injection pump 5, the two-way valve 6, the gas device 7, the raw liquid device 1, the waste liquid collection device 3, and the dilution water device 4 according to the received signals to perform corresponding dilution, packaging or cleaning work.

[0040] Example 3

[0041] A radionuclide ion distribution system, the schematic diagram of the device structure is as follows Figure 3 , 4As shown, it includes a box body 18, a multi-way valve 2, a two-way valve 6, a top plate 19, a placement plate 24, and a hook 25 are installed on the outside of the box body 18, and a control box is installed inside the box body 18. The control box is installed on the panel opposite to the top plate 19. A screw mounting block 30, a guide rail 31, and a sensor mounting adjustment plate 33 are installed. A syringe bracket 20 is installed on the top plate 19, and the middle part of the syringe pump 5 is installed on the syringe bracket 20 through the upper pressing plate 21 and bolts. The upper end of the syringe pump 5 is installed on the stepper motor mounting plate 23 through the pressing plate 22 and bolts. The other end of the stepper motor mounting plate 23 passes through the through slot 27 on the box body 18 and is installed on the slider 32. The slider 32 is slidably connected to the guide rail 31. A stepper motor 29 and a screw 28 are installed below the stepper motor mounting plate 23. The two ends of the screw 28 are installed on the screw mounting block 30. A slot-type photoelectric switch infrared sensor 9 is installed between the screw mounting block 30 and the sensor mounting adjustment plate 33. The stock liquid device 1 and the waste liquid collection device 3 are placed on the placement plate 24, and the dilution water device 4 is hung on the hook 25. The stock liquid device 1, the waste liquid collection device 3, the dilution water device 4, the injection pump 5, the two-way valve 6, the multi-way valve 2 and the synthesizer 8 are connected through the conduit 26. The two-way valve 6 is also connected to the gas device 7 (not shown in the figure) through the conduit 26. Among them, the stock liquid device 1 is a syringe bottle with a rubber stopper, with a capacity of 10 to 30 ml; the waste liquid collection device 3 is a syringe bottle with a rubber stopper, with a capacity of 1000 ml, and the number of synthesizers 8 is 3 (not fully shown in the figure); the dilution water device 4 is a dilution water bag. The power requirements of the system are voltage 110 to 220 V, power 300 W, and the system gas requirements are gas pressure of at least 70 Psi. Preferably, both ends of the catheter 26 for infusion are connected with Luer connectors, and the other end of the Luer connector is connected to the port of the syringe bottle or the multi-way valve 2 or the port of the two-way valve 6 or the port of the dilution water device 4. The use of the Luer connector makes the catheter 26 threaded, which is convenient for the replacement of the catheter 26. The catheter 26 for infusion connected to the syringe bottle is connected with a needle, and the needle passes through the rubber stopper and extends into the syringe bottle to extract liquid. The syringe bottle is also connected with a catheter 26 for exhaust, one end of the catheter 26 for exhaust passes through the rubber stopper and extends into the syringe bottle, and the other end is connected to the atmosphere through a filter. The setting of the catheter 26 for exhaust makes the air pressure in the syringe bottle consistent with the atmospheric pressure, which is convenient for the injection pump 5 to extract or release liquid, and also convenient for avoiding atmospheric contamination of the liquid (the Luer connector, needle, catheter 26 for exhaust, and filter are all existing and will not be elaborated. Figure 3 are not shown in the figure).

[0042] The stepper motor 29 rotates, driving the screw rod 28 to rotate, and then the stepper motor mounting plate 23 drives the injection pump 5 to move up and down under the longitudinal limitation of the slider 32 and the guide rail 31 to perform extraction work, that is, the acquisition of the original liquid, gas and dilution water and the packaging of the dilution liquid. The setting of the slot-type photoelectric switch infrared sensor 9 can accurately obtain and control the moving distance of the stepper motor 29, that is, the moving distance of the stepper motor mounting plate 23, and thus can accurately control the extraction and discharge volume of the injection pump 5.

[0043] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the embodiments of the present invention rather than to limit them. Although the embodiments of the present invention have been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the embodiments of the present invention can still be modified or replaced by equivalents, and these modifications or equivalent replacements cannot cause the modified technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A radioactive nuclide ion distribution system, comprising a stock solution device (1), a multi-way valve (2), a waste liquid collection device (3), a dilution water device (4), an injection pump (5), a two-way valve (6), and a gas device (7), wherein the multi-way valve (2) is provided with a nuclide ion receiving port (201) connected to a nuclide ion output end of the stock solution device (1), a waste liquid discharge port (202) connected to the waste liquid collection device (3), a dilution water receiving port (203) connected to the dilution water device (4), an injection port (204) connected to the two-way valve (6), and a plurality of nuclide ion dispensing ports (205). 05), the injection pump (5) is connected to the two-way valve (6), the two-way valve (6) is connected to the gas device (7), the nuclide ion dispensing port (205) is connected to the synthesizer (8), the number of the synthesizers (8) is greater than or equal to three, the synthesizers (8) are placed in the hot chamber (10), and a start-and-stop safety interlocking device (11) is provided between the hot chambers (10). The nuclide ion receiving port (201), the dilution water receiving port (203) and the injection port (204) on the multi-way valve (2) are opened, and the injection pump (5) extracts the stock solution from the stock solution device (1) through the two-way valve (6) and the multi-way valve (2) in sequence. , after extracting dilution water and a certain amount of boosting air from the dilution water device (4), close the nuclide ion receiving port (201), the dilution water receiving port (203) and the injection port (204), open any nuclide ion dispensing port (205), push the stock solution, dilution water and boosting air in the injection pump (5) into the corresponding dispensing channel, then open the normally closed port of the two-way valve (6), so that the compressed argon gas in the gas device (7) is released through the proportional control valve (13) to push the dilution stock solution for transmission, and send the dilution stock solution into the synthesizer (8). The use of boosting air can make the injection pump (5) push the dilution solution and push the argon gas in the gas device (7) to the synthesizer (8). There is no liquid residue, and the filling dosage is accurately controlled. The boosting air can be obtained from the waste liquid discharge port (202) connected to the waste liquid collection device (3). After all the filling is completed and the synthesizer (8) has finished working and the finished drug is transferred to the filling hot chamber, the dilution water receiving port (203) and the injection port (204) are opened, so that the injection pump (5) can extract dilution water to clean the multi-way valve (2) and all pipelines connected to the multi-way valve (2). Finally, the dilution water receiving port (203) is closed, and the waste liquid discharge port (202) is opened, so that the injection pump (5) can push the cleaning waste liquid into the waste liquid collection device (3).

2. A radionuclide ion distribution system according to claim 1, characterized in that: The opening and closing safety interlocking device (11) is an alarm bell or a warning light.

3. A radionuclide ion distribution system according to claim 1, characterized in that: The injection pump (5) is provided with a dosage calibrator (12).

4. A radionuclide ion distribution system according to claim 3, characterized in that: The maximum measurement value of the dose calibrator (12) is 20Ci.

5. A radionuclide ion distribution system according to claim 1, characterized in that: A proportional regulating valve (13) is provided between the two-way valve (6) and the gas device (7).

6. A radionuclide ion distribution system according to claim 1, characterized in that: The nuclide ion input end of the stock solution device (1) is connected to the cyclotron (9).

7. A radionuclide ion distribution system according to claim 1, characterized in that: The valve cores of the multi-way valve (2) and the two-way valve (6) are both made of sapphire.

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