Sample analyzer and liquid supply method thereof

Abstract

A sample analyzer and a liquid supply method thereof, the sample analyzer comprising a liquid supply assembly, a driving assembly, a sampling assembly, a reaction assembly, a detection assembly, a waste liquid treatment assembly and a controller; wherein the liquid supply assembly comprises a first liquid storage pool, a second liquid storage pool and a liquid using assembly, the first liquid storage pool is in communication with the liquid using assembly to supply liquid to the liquid using assembly, the second liquid storage pool is in communication with the liquid using assembly, and when the liquid in the first liquid storage pool is insufficient, the second liquid storage pool supplies liquid to the liquid using assembly. By arranging the first liquid storage pool and the second liquid storage pool, the first liquid storage pool supplies liquid to the liquid using assembly, and when the liquid in the first liquid storage pool is insufficient, the second liquid storage pool supplies liquid to the liquid using assembly, thereby realizing continuous liquid supply.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a sample analyzer and its liquid supply method. Background Technology

[0002] In existing sample analyzers, when the liquid in the reservoir is depleted and needs replenishment, the common method is to switch the reservoir pressure to negative pressure. Using the pressure difference between the reagent tank and the reservoir, liquid from the reagent tank is poured into the reservoir. After filling, the reservoir switches back to positive pressure to supply liquid externally. However, during the filling process, the negative pressure within the reservoir prevents further liquid supply, forcing the tubing in the sample analyzer that requires the aforementioned liquid to stop operating, thus reducing the analyzer's efficiency. Summary of the Invention

[0003] In view of the above, the purpose of this invention is to provide a sample analyzer capable of continuous liquid supply and a liquid supply method thereof.

[0004] To achieve the objectives of this invention, the following technical solution is provided:

[0005] In a first aspect, the present invention provides a sample analyzer, comprising a liquid supply component, a driving component, a sampling component, a reaction component, a detection component, a waste liquid treatment component, and a controller; the liquid supply component is used for supplying liquid; the driving component is used for driving the flow path in the sample analyzer; the sampling component is used for collecting and dispensing biological samples; the reaction component is used for processing the biological samples to form a test solution; the detection component is used for detecting the test solution to form detection information; the waste liquid treatment component is used for collecting and discharging waste liquid in the sample analyzer; and the controller is used for controlling the workflow of the sample analyzer and processing the detection information to form analysis results.

[0006] The liquid supply assembly includes a first liquid storage tank, a second liquid storage tank, and a liquid application assembly. The first liquid storage tank is connected to the liquid application assembly to supply liquid to the liquid application assembly. The second liquid storage tank is connected to the liquid application assembly. When the liquid in the first liquid storage tank is insufficient, the second liquid storage tank supplies liquid to the liquid application assembly.

[0007] The second liquid storage tank and the liquid application component are provided with a first switching component, which is used to connect or disconnect the second liquid storage tank and the liquid application component.

[0008] The first switching component is also disposed between the first liquid storage tank and the liquid application component, and the first switching component is used to connect or disconnect the first liquid storage tank or the second liquid storage tank from the liquid application component.

[0009] The first switching component includes a third valve and a fourth valve. The third valve is disposed between the first liquid storage tank and the liquid application component, and the fourth valve is disposed between the second liquid storage tank and the liquid application component. Both the third valve and the fourth valve are used to connect or disconnect the liquid.

[0010] The third valve and / or the fourth valve are one-way valves, which allow liquid from the first or second liquid storage tank to flow into the liquid-using component, while preventing reverse flow.

[0011] The liquid supply assembly further includes a reagent tank and a fourth switching component. The reagent tank is connected to the first liquid storage tank through the fourth switching component, and the fourth switching component is used to connect or disconnect the reagent tank from the first liquid storage tank.

[0012] The reagent tank is also connected to the second liquid storage tank via the fourth switching component.

[0013] The fourth switching component includes a first valve and a second valve. The first valve is disposed between the first liquid storage tank and the reagent tank, and the second valve is disposed between the second liquid storage tank and the reagent tank. Both the first valve and the second valve are used to connect or disconnect.

[0014] The first valve and the second valve are one-way valves, which allow the liquid in the reagent tank to flow into the first storage tank or the second storage tank, while preventing reverse flow.

[0015] A fifth switching component is provided between the fourth switching component and the reagent container. The fifth switching component is used to connect or disconnect the reagent container from the fourth switching component to prevent liquid leakage from the fourth switching component from flowing into the reagent container.

[0016] The liquid supply assembly further includes a first positive pressure source and a first negative pressure source connected to the first liquid storage tank; when the first liquid storage tank supplies liquid to the liquid application assembly, the first positive pressure source pressurizes the first liquid storage tank; when the liquid in the first liquid storage tank is insufficient and filling is required, the first negative pressure source depressurizes the liquid storage tank.

[0017] The liquid supply assembly further includes a second positive pressure source and a closed end connected to the second liquid storage tank. When the first liquid storage tank is filled with liquid, the second positive pressure source pressurizes the second liquid storage tank so that the second liquid storage tank supplies liquid to the liquid use assembly. When the first liquid storage tank supplies liquid to the second liquid storage tank and the second liquid storage tank supplies liquid to the liquid use assembly, the second liquid storage tank is connected to the closed end.

[0018] The liquid supply assembly further includes a third switching component, which is disposed between the second positive pressure source and the closed end and the second liquid storage tank. The third switching component is used to connect or disconnect the second liquid storage tank from the second positive pressure source or the closed end.

[0019] The liquid supply assembly further includes a seventh switching element and a second negative pressure source or atmospheric end. The seventh switching element is connected to the third switching element. The second positive pressure source, the closed end, and the second negative pressure source or atmospheric end are connected to the second liquid storage tank through the seventh switching element and the third switching element. When the first liquid storage tank fills the second liquid storage tank with liquid, the second negative pressure source reduces the pressure of the second liquid storage tank, or the atmospheric end connects the second liquid storage tank to the atmosphere.

[0020] A sixth switching element is provided between the first liquid storage tank and the second liquid storage tank. The sixth switching element connects the first liquid storage tank and the second liquid storage tank, and the first liquid storage tank is connected to the liquid application component through the second liquid storage tank. When the first liquid storage tank supplies liquid to the second liquid storage tank and supplies liquid to the liquid application component through the second liquid storage tank, the sixth switching element connects the first liquid storage tank and the second liquid storage tank. When the first liquid storage tank fills the second liquid storage tank, the sixth switching element connects the second liquid storage tank, and the first switching element disconnects the second liquid storage tank from the liquid application component. When the first liquid storage tank is filling and the second liquid storage tank supplies liquid to the liquid application component, the sixth switching element disconnects the first liquid storage tank from the second liquid storage tank.

[0021] The volume of the first liquid storage tank is larger than that of the second liquid storage tank.

[0022] Secondly, embodiments of the present invention also provide a liquid supply method for a sample analyzer, comprising:

[0023] The first liquid storage tank supplies liquid to the liquid-using components;

[0024] When the liquid in the first storage tank is insufficient, the second storage tank is used to supply liquid to the liquid-using component.

[0025] The step of filling the first storage tank with liquid when the liquid in the first storage tank is insufficient includes:

[0026] The first liquid storage tank is connected to the reagent container, and the first negative pressure source reduces the pressure of the first liquid storage tank so that the liquid in the reagent container flows into the first liquid storage tank under the action of pressure difference.

[0027] The step of "supplying liquid to the liquid-using components from the second liquid storage tank" includes:

[0028] The first switching element connects the second liquid storage tank and the liquid application component, and the second positive pressure source pressurizes the second liquid storage tank so that the liquid in the second liquid storage tank flows into the liquid application component.

[0029] When the first liquid storage tank is filling with liquid and the second liquid storage tank is supplying liquid to the liquid application component, the first switching component disconnects the first liquid storage tank from the liquid application component, and the first switching component connects the second liquid storage tank to the liquid application component.

[0030] When the first liquid storage tank is filling with liquid and the second liquid storage tank is supplying liquid to the liquid-using component, the sixth switching component disconnects the connection between the first liquid storage tank and the second liquid storage tank.

[0031] The step of "the first liquid storage tank supplying liquid to the liquid-using component" includes:

[0032] The first switching element connects the first liquid storage tank and the liquid application component, the first switching element disconnects the second liquid storage tank and the liquid application component, and the first positive pressure source pressurizes the first liquid storage tank.

[0033] When the liquid in the second storage tank is insufficient, the liquid supply method further includes:

[0034] The sixth switching element connects the first liquid storage tank and the second liquid storage tank, the first switching element disconnects the second liquid storage tank from the liquid application component, the first positive pressure source pressurizes the first liquid storage tank, and the second negative pressure source depressurizes the second liquid storage tank, so that the first liquid storage tank fills the second liquid storage tank with liquid.

[0035] When the first and second liquid storage tanks are sufficiently filled, the liquid supply method further includes:

[0036] The sixth switching element connects the first liquid storage tank and the second liquid storage tank. The first liquid storage tank supplies liquid to the second liquid storage tank, while the second liquid storage tank supplies liquid to the liquid-using component. The liquid level in the second liquid storage tank does not decrease.

[0037] The liquid supply method further includes:

[0038] The first positive pressure source pressurizes the first liquid storage tank, and the closed end seals the second liquid storage tank, so that the pressure inside the second liquid storage tank is constant.

[0039] The liquid supply method further includes:

[0040] The sixth switching element connects the first liquid storage tank and the second liquid storage tank. The first positive pressure source pressurizes the first liquid storage tank, the atmospheric end connects the second liquid storage tank to the atmosphere, and the first switching element disconnects the second liquid storage tank from the liquid application component.

[0041] The present invention provides a sample analyzer that, by setting up a first liquid storage tank and a second liquid storage tank, supplies liquid to the liquid-using components. When the liquid in the first liquid storage tank is insufficient, the second liquid storage tank is used to supply liquid to the liquid-using components, thereby achieving continuous liquid supply. Attached Figure Description

[0042] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0043] Figure 1 This is a schematic diagram of the liquid supply component of a sample analyzer provided in an embodiment of the present invention.

[0044] Figure 2 This is a schematic diagram of the liquid supply component of another sample analyzer provided in an embodiment of the present invention.

[0045] Figure 3 This is a schematic diagram of the liquid supply component of another sample analyzer provided in an embodiment of the present invention.

[0046] Figure 4 This is a schematic diagram of the liquid supply component of another sample analyzer provided in an embodiment of the present invention.

[0047] Figure 5 This is a schematic diagram of the liquid supply component of another sample analyzer provided in an embodiment of the present invention.

[0048] Figure 6 This is a schematic diagram of the liquid supply component of another sample analyzer provided in an embodiment of the present invention.

[0049] Figure 7 This is a schematic diagram of the liquid supply component of another sample analyzer provided in an embodiment of the present invention.

[0050] Figure 8 This is a schematic diagram of the liquid supply component of another sample analyzer provided in an embodiment of the present invention. Detailed Implementation

[0051] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0052] This invention provides a sample analyzer. The sample analyzer can be used to analyze biological samples, such as blood and urine.

[0053] The sample analyzer includes a liquid supply assembly, a drive assembly, a sampling assembly, a reaction assembly, a detection assembly, a waste liquid treatment assembly, and a controller. The liquid supply assembly supplies liquid to the sample analyzer. The drive assembly drives the various flow paths (including gas and liquid paths) within the sample analyzer. The drive assembly includes multiple gas tanks and a gas pump, which establishes positive and negative pressures within the multiple gas tanks for actuation. The sampling assembly collects and dispenses biological samples. The sampling assembly includes a sampling needle. The reaction assembly processes the biological samples to form the analyte. The reaction assembly includes multiple reaction cells or flow chambers. The detection assembly detects the analyte to generate detection information. The detection assembly includes a flow chamber. The waste liquid treatment assembly collects and discharges waste liquid from the sample analyzer. The controller controls the workflow of the sample analyzer and processes the detection information to generate analytical results.

[0054] Please refer to Figure 1 and Figure 5 This invention provides a sample analyzer, whose liquid supply component includes a first liquid storage tank 1, a second liquid storage tank 2, and a liquid application component 3. The first liquid storage tank 1 is connected to the liquid application component 3 to supply liquid to the liquid application component 3. The second liquid storage tank 2 is connected to the liquid application component 3. When the liquid in the first liquid storage tank 1 is insufficient, the second liquid storage tank 2 supplies liquid to the liquid application component 3.

[0055] In this embodiment, by setting up a first liquid storage tank 1 and a second liquid storage tank 2, the first liquid storage tank 1 supplies liquid to the liquid-using component 3. When the liquid in the first liquid storage tank 1 is insufficient, the second liquid storage tank 2 is used to supply liquid to the liquid-using component 3, so as to achieve continuous liquid supply.

[0056] It should be understood that in this embodiment, the first liquid storage tank 1 and the liquid application component 3 can be directly connected, such as... Figure 1 As shown, it can also be indirectly connected, such as... Figure 5 As shown, the first liquid storage tank 1 is connected to the liquid-using component through the second liquid storage tank 2.

[0057] In one embodiment, please refer to Figure 1 The first liquid storage tank 1 and the second liquid storage tank 2 are connected in parallel. When the liquid in the first liquid storage tank 1 is insufficient and filling is required, the second liquid storage tank 2 is used to supply liquid to the liquid-using component 3. When the liquid in the second liquid storage tank 2 is insufficient and filling is required, the first liquid storage tank 1 is used to supply liquid to the liquid-using component 3, so that the liquid-using component 3 can always have a liquid supply and achieve continuous liquid supply.

[0058] Optionally, the first liquid storage tank 1 and the second liquid storage tank 2 have the same shape and structure, and the same volume, which facilitates manufacturing and spare parts.

[0059] Optionally, the liquid application component 3 can be a reaction component or a detection component. For example, the liquid application component 1 can be a reaction tank or a flow chamber. The first liquid storage tank 1 and the second liquid storage tank 2 can be used to store the diluent.

[0060] Optionally, a first liquid level sensor is installed in the first liquid storage tank 1 to detect the liquid level height in the first liquid storage tank 1. A second liquid level sensor is installed in the second liquid storage tank 2 to detect the liquid level height in the second liquid storage tank 2. The first liquid level sensor and the second liquid level sensor can be float sensors.

[0061] In one embodiment, a first switching element 41 is provided between the first liquid storage tank 1 and the second liquid storage tank 2 and the liquid application component 3. The first liquid storage tank 1 is connected to the liquid application component 3 via the first switching element 41, and the second liquid storage tank 2 is also connected to the liquid application component 3 via the first switching element 41. The first switching element 41 is used to switch the connection state between the first liquid storage tank 1 or the second liquid storage tank 2 and the liquid application component 3. In other words, the first switching element 41 is used to connect or disconnect the first liquid storage tank 1 and the liquid application component 3. The first switching element 41 is also used to connect or disconnect the second liquid storage tank 2 and the liquid application component 3, and the first liquid storage tank 1 and the second liquid storage tank 2 are not connected or disconnected simultaneously, but rather alternately. That is, when the first switching element 41 connects the first liquid storage tank 1 and the liquid application component 3, it disconnects the second liquid storage tank 2 and the liquid application component 3; when the first switching element 41 connects the second liquid storage tank 2 and the liquid application component 3, it disconnects the first liquid storage tank 1 and the liquid application component 3.

[0062] In this embodiment, when the first switching element 41 connects the first liquid storage tank 1 and the liquid application component 3, the first liquid storage tank 1 is used to supply liquid to the liquid application component 3. At this time, the first switching element 41 disconnects the connection between the second liquid storage tank 2 and the liquid application component 3, and the second liquid storage tank 2 can be filled. When the first switching element 41 connects the second liquid storage tank 2 and the liquid application component 3, the second liquid storage tank 2 is used to supply liquid to the liquid application component 3. At this time, the first switching element 41 disconnects the connection between the first liquid storage tank 1 and the liquid application component 3, and the first liquid storage tank 1 can be filled. The first switching element 41 can be a single two-position three-way solenoid valve or two shut-off valves.

[0063] In one embodiment, a first liquid storage tank 1 is connected to a first positive pressure source 12 and a first negative pressure source 13, and a second liquid storage tank 2 is connected to a second positive pressure source 22 and a second negative pressure source 23. The first positive pressure source 12 pressurizes the first liquid storage tank 1, causing the liquid in the first liquid storage tank 1 to flow to the liquid application component 3 under pressure. The first negative pressure source 13 depressurizes the first liquid storage tank 1, making the pressure inside the first liquid storage tank 1 lower than the external pressure (e.g., atmospheric pressure), thus giving the first liquid storage tank 1 suction for filling it with liquid. Similarly, the second positive pressure source 22 supplies liquid from the second liquid storage tank 2 to the liquid application component 3, and the second negative pressure source 23 fills the second liquid storage tank 2 with liquid.

[0064] Optionally, a second switching component 11 is provided between the first positive pressure source 12 and the first negative pressure source 13 and the first liquid storage tank 1. The second switching component 11 is used to switch the connection state between the first liquid storage tank 1 and the first positive pressure source 12 or the first negative pressure source 13.

[0065] Specifically, when the second switching element 11 connects the first positive pressure source 12 to the first liquid storage tank 1, it disconnects the first negative pressure source 13 from the first liquid storage tank 1; when the second switching element 11 connects the first negative pressure source 13 to the first liquid storage tank 1, it disconnects the first positive pressure source 12 from the first liquid storage tank 1. The second switching element 11 can be a single two-position three-way solenoid valve or two shut-off valves.

[0066] Optionally, a third switching element 21 is provided between the second positive pressure source 22 and the second negative pressure source 23 and the second liquid storage tank 2. The third switching element 21 is used to switch the connection state between the second liquid storage tank 2 and the second positive pressure source 22 or the second negative pressure source 23.

[0067] Specifically, when the third switching element 21 connects the second positive pressure source 22 to the second liquid storage tank 2, it disconnects the second negative pressure source 23 from the second liquid storage tank 2; when the third switching element 21 connects the second negative pressure source 23 to the second liquid storage tank 2, it disconnects the second positive pressure source 22 from the second liquid storage tank 2. The third switching element 21 can be a single two-position three-way solenoid valve or two shut-off valves.

[0068] In one embodiment, the liquid supply assembly further includes a reagent tank 5, which is connected to a first liquid storage tank 1 and a second liquid storage tank 2. When the first liquid storage tank 1 is connected to a first negative pressure source 13, or the second liquid storage tank 2 is connected to a second negative pressure source 23, the reagent tank 5 fills the first liquid storage tank 1 or the second liquid storage tank 2 with liquid, that is, the liquid in the reagent tank 5 enters the first liquid storage tank 1 or the second liquid storage tank 2 under the action of pressure difference.

[0069] Optionally, a fourth switching element 42 is provided between the first liquid storage tank 1 and the second liquid storage tank 2 and the reagent tank 5. The fourth switching element 42 is used to switch the connection state between the reagent tank 5 and the first liquid storage tank 1 or the second liquid storage tank 2.

[0070] Specifically, when the fourth switching element 42 connects the first liquid storage tank 1 and the reagent tank 5, it disconnects the second liquid storage tank 2 and the reagent tank 5; when the fourth switching element 42 connects the second liquid storage tank 2 and the reagent tank 5, it disconnects the first liquid storage tank 1 and the reagent tank 5.

[0071] In this embodiment, the fourth switching component 42 includes a first valve 421 and a second valve 422. The first valve 421 is disposed between the first liquid storage tank 1 and the reagent tank 5 for connecting or disconnecting; the second valve 422 is disposed between the second liquid storage tank 2 and the reagent tank 5 for connecting or disconnecting. The first valve 421 and the second valve 422 can be shut-off valves.

[0072] Preferably, a first tee connector 423 is provided between the first valve 421, the second valve 422 and the reagent tank 5, such that the first valve 421 is located between the first liquid storage tank 1 and the first tee connector 423, and the second valve 422 is located between the second liquid storage tank 2 and the first tee connector 423. The first tee connector 423 is used to distribute the liquid from the reagent tank 5 to the first valve 421 and the second valve 422.

[0073] In one embodiment, please refer to Figure 2 The first switching component 41 includes a third valve 411 and a fourth valve 412. The third valve 411 is disposed between the first liquid storage tank 1 and the liquid-using component 3 for connecting or disconnecting; the fourth valve 412 is disposed between the second liquid storage tank 2 and the liquid-using component 3 for connecting or disconnecting.

[0074] Specifically, when the third valve 411 connects the first liquid storage tank 1 and the liquid application component 3, the fourth valve 412 disconnects the second liquid storage tank 2 and the liquid application component 3; when the fourth valve 412 connects the second liquid storage tank 2 and the liquid application component 3, the third valve 411 disconnects the first liquid storage tank 1 and the liquid application component 3.

[0075] In this embodiment, the third valve 411 and the fourth valve 412 are one-way valves, which allow the liquid from the first liquid storage tank 1 or the second liquid storage tank 2 to flow into the liquid-using component 3, but prevent it from flowing in the opposite direction, thus avoiding the liquid from the liquid-using component 3 from contaminating the first liquid storage tank 1 or the second liquid storage tank 2.

[0076] Preferably, a second tee connector 413 is provided between the third valve 411, the fourth valve 412 and the liquid-using assembly 3. The second tee connector 413 is used to connect the liquid from the third valve 411 or the fourth valve 412 to the liquid-using assembly 3.

[0077] In one embodiment, please continue to refer to Figure 2The first valve 421 and / or the second valve 422 of the fourth switching element 42 are one-way valves. The first valve 421 allows the liquid from the reagent tank 5 to flow into the first storage tank 1, but does not allow it to flow in the reverse direction; the second valve 422 allows the liquid from the reagent tank 5 to flow into the second storage tank 2, but does not allow it to flow in the reverse direction. Using one-way valves can reduce costs.

[0078] In this embodiment, a first tee connector 423 can also be provided between the first valve 421 and the second valve 422 and the reagent tank 5, so that the first valve 421 is located between the first liquid storage tank 1 and the first tee connector 423, and the second valve 422 is located between the second liquid storage tank 2 and the first tee connector 423. The first tee connector 423 is used to distribute the liquid from the reagent tank 5 to the first valve 421 and the second valve 422.

[0079] In one embodiment, please refer to Figure 3 A fifth switching element 51 is provided between the first valve 421 and the second valve 422 and the reagent container 5. The fifth switching element 51 is used to connect or disconnect the connection between the first valve 421 and the second valve 422 and the reagent container 5.

[0080] Preferably, the fifth switching element 51 is disposed between the first three-way connector 423 and the reagent container 5. When the first valve 421 and / or the second valve 422 are one-way valves, to prevent possible backflow of liquid from the first valve 421 and / or the second valve 422, the fifth switching element 51 can be switched to a state that disconnects the first valve 421 and the second valve 422 from the reagent container 5, so that the liquid in the first liquid storage tank 1 and / or the second liquid storage tank 2 will not flow back into the reagent container 5 and cause contamination. The fifth switching element 51 is preferably a two-way solenoid valve.

[0081] In one embodiment, please refer to Figure 4 The fourth switching element 42 is a single two-position three-way valve. The first liquid storage tank 1, the second liquid storage tank 2 and the reagent tank 5 are all connected to the fourth switching element 42. The fourth switching element 42 is used to connect or disconnect the reagent tank 5 from the first liquid storage tank 1 and / or the second liquid storage tank 2.

[0082] In this embodiment, a fifth switching element 51 is provided between the fourth switching element 42 and the reagent tank 5. The fifth switching element 51 is a one-way valve that allows the liquid in the reagent tank 5 to flow to the fourth switching element 42, but does not allow it to flow in the opposite direction.

[0083] In one embodiment, please refer to Figure 5 The first liquid storage tank 1 and the second liquid storage tank 2 are connected, and the second liquid storage tank 2 is connected to the liquid supply assembly 3. The liquid in the first liquid storage tank 1 flows into the second liquid storage tank 2, and then into the liquid supply assembly 3, so as to achieve continuous liquid supply.

[0084] Preferably, the volume of the first liquid storage tank 1 is larger than that of the second liquid storage tank 2, which can save space.

[0085] Preferably, a first switching element 41 is also provided between the second liquid storage tank 2 and the liquid supply component 3. The first switching element 41 is used to connect or disconnect the second liquid storage tank 2 and the liquid supply component 3. When the liquid in the second liquid storage tank 2 is insufficient, the first switching element 41 is set to disconnect the second liquid storage tank 2 from the liquid supply component 3, and the second liquid storage tank 2 is filled with the first liquid storage tank 1; when the liquid in the second liquid storage tank 2 is sufficient, the first switching element 41 is opened again to continue the liquid supply.

[0086] Preferably, a sixth switching element 43 is provided between the first liquid storage tank 1 and the second liquid storage tank 2. The sixth switching element 43 is used to connect or disconnect the first liquid storage tank 1 and the second liquid storage tank 2. When the liquid in both the first liquid storage tank 1 and the second liquid storage tank 2 is sufficient, the sixth switching element 43 connects the first liquid storage tank 1 and the second liquid storage tank 2, and the first switching element 41 connects the second liquid storage tank 2 and the liquid supply component 3. The liquid in the first liquid storage tank 1 flows into the second liquid storage tank 2, and the liquid in the second liquid storage tank 2 flows into the liquid supply component 3 to maintain continuous liquid supply and ensure that the liquid in the second liquid storage tank 2 remains sufficient. When the liquid in the first liquid storage tank 1 becomes insufficient after a period of liquid supply, the sixth switching element 43 disconnects the first liquid storage tank 1 and the second liquid storage tank 2, and the first liquid storage tank 1 is refilled. At the same time, the first switching element 41 continues to connect the second liquid storage tank 2 and the liquid supply component 3, and the second liquid storage tank 2 supplies liquid to the liquid supply component 3. When the liquid in the second storage tank 2 is insufficient, the first switching element 41 disconnects the second storage tank 2 from the liquid-using component 3, and the sixth switching element 43 connects the first storage tank 1 and the second storage tank 2, allowing the first storage tank 1 to fill the second storage tank 2. Since the first storage tank 1 is being filled while the second storage tank 2 is being supplied with liquid independently, after the second storage tank 2 has been supplying liquid for a period of time, the first storage tank 1 is filled to a sufficient level and can then be used to fill the second storage tank 2. When the first storage tank 1 is filling the second storage tank 2, the working interval of the liquid-using component 3 can be selected, thus not affecting the liquid usage of the liquid-using component 3.

[0087] In one embodiment, the first liquid storage tank 1 is connected to a first positive pressure source 12 and a first negative pressure source 13. The first positive pressure source 12 is used to pressurize the first liquid storage tank 1, and the first negative pressure source 13 is used to depressurize the first liquid storage tank 1. When the first liquid storage tank 1 supplies liquid to or fills the second liquid storage tank 2, the first positive pressure source 12 pressurizes the first liquid storage tank 1; when the first liquid storage tank 1 is filled, the first negative pressure source 13 depressurizes the first liquid storage tank 1.

[0088] Preferably, a second switching element 11 may be provided between the first positive pressure source 12 and the first negative pressure source 13 and the first liquid storage tank 1. The second switching element 11 is used to switch the connection state between the first liquid storage tank 1 and the first positive pressure source 12 or the first negative pressure source 13, that is, to connect or disconnect.

[0089] In one embodiment, the second liquid storage tank 2 is connected to a second positive pressure source 22 and a second negative pressure source 23. The second positive pressure source 22 is used to pressurize the second liquid storage tank 2, and the second negative pressure source 23 is used to depressurize the second liquid storage tank 2. When the first liquid storage tank 1 is filled and the second liquid storage tank 2 is used for liquid supply, the second positive pressure source 22 pressurizes the second liquid storage tank 2; when the second liquid storage tank 2 is filled, the first positive pressure source 12 is used to pressurize the first liquid storage tank 1, and the second negative pressure source 23 depressurizes the second liquid storage tank 2. This can accelerate the filling of liquid from the first liquid storage tank 1 into the second liquid storage tank 2, and after it is quickly filled, it can be used for liquid supply, achieving the purpose of liquid supply at short intervals.

[0090] Preferably, a third switching element 21 may be provided between the second positive pressure source 22 and the second negative pressure source 23 and the second liquid storage tank 2. The third switching element 21 is used to switch the connection state between the second liquid storage tank 2 and the second positive pressure source 22 or the second negative pressure source 23, that is, to connect or disconnect.

[0091] In this embodiment, the second liquid storage tank 2 is also connected to a closed end 25, which keeps the pressure inside the second liquid storage tank 2 constant. When the first liquid storage tank 1 supplies liquid to the second liquid storage tank 2, and the second liquid storage tank 2 supplies liquid to the liquid-using component 3, the second liquid storage tank 2 is connected to the closed end 25 to maintain the pressure inside the second liquid storage tank 2, thereby keeping the liquid level in the second liquid storage tank 2 at a certain height without decreasing.

[0092] Preferably, a seventh switching element 24 is provided between the closed end 25 and the third switching element 21 and the second liquid storage tank 2. The seventh switching element 24 is used to switch the connection state between the second liquid storage tank 2 and the closed end 25 or the second positive pressure source 22 / second negative pressure source 23.

[0093] Specifically, when the first liquid storage tank 1 supplies liquid to the second liquid storage tank 2, and the second liquid storage tank 2 supplies liquid to the liquid-using component 3, the seventh switching element 24 switches to connect the second liquid storage tank 2 with the closed end 25; when the first liquid storage tank 1 is filled and the second liquid storage tank 2 supplies liquid to the liquid-using component 3, the seventh switching element 24 switches to connect the second liquid storage tank 2 with the third switching element 21, and the third switching element 21 switches to connect with the second positive pressure source 22, so that the second positive pressure source 22 pressurizes the second liquid storage tank 2; when the first liquid storage tank 1 is filled to the second liquid storage tank 2, the seventh switching element 24 switches to connect the second liquid storage tank 2 with the third switching element 21, and the third switching element 21 switches to connect with the second negative pressure source 23, so that the second negative pressure source 23 depressurizes the second liquid storage tank 2. The seventh switching element 24 can be a single two-position three-way valve or two solenoid valves.

[0094] It should be understood that the second positive pressure source 22, the second negative pressure source 23 / atmospheric end 26, and the closed end 25 are connected to the second liquid storage tank 2 via the seventh switching element 24 and the third switching element 21. The connection positions of the second positive pressure source 22, the second negative pressure source 23 / atmospheric end 26, and the closed end 25 on the seventh switching element 24 and the third switching element 21 can be freely arranged, for example... Figure 5 As shown, the third switching element 21 is connected to the closed end 25, and the seventh switching element 24 is connected to the second positive pressure source 22 and the second negative pressure source 23; For example... Figure 7 As shown, the third switching element 21 is connected to the second positive pressure source 22, and the seventh switching element 24 is connected to the closed end 25 and the atmospheric end 26.

[0095] In one embodiment, the first liquid storage tank 1 is also connected to a reagent tank 5, which is used to supply liquid to the first liquid storage tank 1 when the first liquid storage tank 1 is in the filling state.

[0096] Preferably, a fourth switching element 42 is provided between the first liquid storage tank 1 and the reagent tank 5. The fourth switching element 42 is used to connect or disconnect the fourth switching element 42 from the reagent tank 5. In this embodiment, the fourth switching element 42 is a shut-off valve.

[0097] In one embodiment, please refer to Figure 6 The sixth switching element 43 is a one-way valve. In addition to connecting or disconnecting the first liquid storage tank 1 and the second liquid storage tank 2, the sixth switching element 43 also allows the liquid in the first liquid storage tank 1 to flow into the second liquid storage tank 2, but does not allow it to flow in the opposite direction.

[0098] In one embodiment, the fourth switching element 42 is also a one-way valve. In addition to connecting or disconnecting the first liquid storage tank 1 and the reagent tank 5, the fourth switching element 42 also allows the liquid in the reagent tank 1 to flow into the first liquid storage tank 1, but does not allow it to flow in the reverse direction.

[0099] In one embodiment, please refer to Figure 7 The third switching element 21 is disposed between the second positive pressure source 22 and the seventh switching element 24 and the second liquid storage tank 2. Specifically, the third switching element 21 is used to connect or disconnect the second liquid storage tank 2 from the second positive pressure source 22, and also to connect or disconnect the second liquid storage tank 2 from the seventh switching element 24. The seventh switching element 24 is disposed between the closed end 25 and the atmospheric end 26 and the third switching element 21. Specifically, the seventh switching element 24 is used to connect or disconnect the closed end 25 from the third switching element 21, and also to connect or disconnect the atmospheric end 26 from the third switching element 21. Both the third switching element 21 and the seventh switching element 24 are two-position three-way valves.

[0100] In this embodiment, when the first liquid storage tank 1 supplies liquid to the second liquid storage tank 2, and the second liquid storage tank 2 supplies liquid to the liquid-using component 3, the third switching element 21 is connected to the seventh switching element 24, and the seventh switching element 24 is connected to the closed end 25 to maintain a constant pressure within the second liquid storage tank 2. When the first liquid storage tank 1 is being filled, and the second liquid storage tank 2 is supplying liquid to the liquid-using component 3, the third switching element 21 is connected to the positive pressure source 22 to pressurize the second liquid storage tank 2. When the first liquid storage tank 1 is being filled to the second liquid storage tank 2, the third switching element 21 is connected to the seventh switching element 24, and the seventh switching element 24 is connected to the atmospheric end 26, so that the pressure within the second liquid storage tank 2 is atmospheric pressure. Filling can also be achieved with atmospheric pressure, although the speed is slightly slower, compared to a negative pressure.

[0101] In one embodiment, please refer to Figure 8 The third switching element 21 is located between the second positive pressure source 22 and the seventh switching element 24 and the second liquid storage tank 2. Specifically, the third switching element 21 is used to connect or disconnect the second positive pressure source 22 and the second liquid storage tank 2, and also to connect or disconnect the seventh switching element 24 and the second liquid storage tank 2. The seventh switching element 24 is located between the atmospheric end 26 and the third switching element 21, and is used to connect or disconnect the atmospheric end 26 and the third switching element 21. The third switching element 21 is a two-position three-way valve. The seventh switching element 24 is a two-way valve, with one port connected to the atmospheric end 26 and the other port closed. When the seventh switching element 24 needs to connect to the closed end 25 (see...), it is used to... Figure 7 When the seventh switching element 24 is connected to the closed interface, it achieves the same effect as connecting the closed end 25.

[0102] Understandably, in this embodiment of the invention, the filling and supply actions of the first liquid storage tank 1 and the second liquid storage tank 2 are achieved through precise control of their internal liquid consumption, the status of their internal liquid level sensors, and the filling time. The basic principles are: A. The amount of liquid consumed by each functional sequence in the first liquid storage tank 1 and the second liquid storage tank 2 (i.e., the amount of liquid supplied to the first liquid storage tank 1 and the second liquid storage tank 2) should be less than the total amount in the first liquid storage tank 1 and the second liquid storage tank 2 when they are full. For example, if the total amount is 140 mL, the consumption is 120 mL. B. If each functional sequence consumes liquid from the first liquid storage tank 1 or the second liquid storage tank 2, it must be filled back up before the end of the sequence. C. In each functional sequence, the timing of the infusion is as follows: the first reservoir 1 and the second reservoir 2 are supplied and infused separately. Since there are two reservoirs, the second reservoir 2 can be supplied while the first reservoir 1 is being infused, or the second reservoir 2 can be supplied while the first reservoir 1 is being supplied. Alternatively, the first reservoir 1 can supply liquid to the second reservoir 2, thereby significantly reducing the time spent on instrument measurement and maintenance and improving the flexibility of the timing sequence arrangement.

[0103] Please refer to Figure 1 and Figure 5 This invention also provides a liquid supply method for a sample analyzer, which can be used with the sample analyzer provided in the above embodiments. The liquid supply method can be used with the sample analyzer provided in the above embodiments.

[0104] The liquid supply method includes:

[0105] The first liquid storage tank 1 supplies liquid to the liquid-using component 3;

[0106] When the liquid in the first liquid storage tank 1 is insufficient, the second liquid storage tank 2 is used to supply liquid to the liquid-using component 3.

[0107] In this embodiment, the first liquid storage tank 1 is used to supply liquid to the liquid-using component 3. When the liquid in the first liquid storage tank 1 is insufficient, the second liquid storage tank 2 is used to supply liquid to the liquid-using component 3 to achieve continuous liquid supply.

[0108] In one embodiment, please refer to Figure 1 When the liquid in the first storage tank 1 is insufficient, the step of filling the first storage tank 1 with liquid includes:

[0109] The first liquid storage tank 1 is connected to the reagent tank 5, and the first negative pressure source 13 reduces the pressure of the first liquid storage tank 1 so that the liquid in the reagent tank 5 flows into the first liquid storage tank 1 under the action of pressure difference.

[0110] For further details, please refer to... Figure 1 or Figure 5 The first liquid storage tank 1 and the reagent tank 5 are connected by the fourth switching component 42. The fourth switching component 42 can also disconnect the first liquid storage tank 1 and the reagent tank 5.

[0111] For further details, please refer to... Figure 1 The fourth switching component 42 can also connect the second liquid storage tank 2 and the reagent tank 5, so that the reagent tank 5 can also fill the second liquid storage tank 2 with liquid.

[0112] In one embodiment, please refer to Figure 1 or Figure 5 The step of "supplying liquid to the liquid-using component 3 from the second liquid storage tank 2" includes:

[0113] The first switching element 41 connects the second liquid storage tank 2 and the liquid application component 3, and the second positive pressure source 22 pressurizes the second liquid storage tank 2 so that the liquid in the second liquid storage tank 2 flows into the liquid application component 3.

[0114] In one embodiment, please refer to Figure 2When the first storage tank 1 is filling with liquid and the second storage tank 2 is supplying liquid to the liquid-using component 3, the third valve 411 of the first switching element 41 disconnects the first storage tank 1 from the liquid-using component 3, and the fourth valve 412 connects the second storage tank 2 to the liquid-using component 3. For further details, please refer to... Figure 2 The first valve 421 of the third switching component 42 connects the first liquid storage tank 1 and the reagent tank 5, and the second valve 422 disconnects the second liquid storage tank 2 and the reagent tank 5.

[0115] In one embodiment, please refer to Figure 5 When the first liquid storage tank 1 is filling with liquid and the second liquid storage tank 2 is supplying liquid to the liquid-using component 3, the sixth switching component 43 disconnects the connection between the first liquid storage tank 1 and the second liquid storage tank 2.

[0116] In one embodiment, please refer to Figure 1 The steps of "supplying liquid to the first liquid storage tank 1 for the liquid-using component 3" include:

[0117] The third valve 411 of the first switching component 41 connects the first liquid storage tank 1 and the liquid application component 3, the fourth valve 412 cuts off the second liquid storage tank 2 and the liquid application component 3, and the first positive pressure source 12 pressurizes the first liquid storage tank 1.

[0118] In one embodiment, please refer to Figure 5 When the liquid in the second storage tank 2 is insufficient, the liquid supply method further includes:

[0119] The sixth switching element 43 connects the first liquid storage tank 1 and the second liquid storage tank 2. The first switching element 41 disconnects the second liquid storage tank 2 from the liquid application component 3. The first positive pressure source 12 pressurizes the first liquid storage tank 1, and the second negative pressure source 23 depressurizes the second liquid storage tank 2, so that the first liquid storage tank 1 injects liquid into the second liquid storage tank 3.

[0120] In one embodiment, please refer to Figure 5 When the liquid in the first storage tank 1 and the second storage tank 2 is sufficient, the liquid supply method further includes:

[0121] The sixth switching component 43 connects the first liquid storage tank 1 and the second liquid storage tank 2. The first liquid storage tank 1 supplies liquid to the second liquid storage tank 2, while the second liquid storage tank 2 supplies liquid to the liquid application component 3, and the liquid level in the second liquid storage tank 2 does not decrease.

[0122] In one embodiment, please refer to Figure 5 The liquid supply method further includes:

[0123] The first positive pressure source 12 pressurizes the first liquid storage tank 1, and the closed end 25 seals the second liquid storage tank 2, so that the pressure inside the second liquid storage tank 2 is constant.

[0124] For further details, please refer to... Figure 5 The steps of "supplying liquid to the liquid-using component 3 from the second liquid storage tank 2" include:

[0125] The first switching element 41 connects the second liquid storage tank 2 and the liquid application component 3, so that when the liquid in the first liquid storage tank 1 enters the second liquid storage tank 2, the second liquid storage tank 2 supplies liquid to the liquid application component 3, and keeps the liquid level in the second liquid storage tank 2 from decreasing.

[0126] In one embodiment, please refer to Figure 7 The liquid supply method further includes:

[0127] The sixth switching component 43 connects the first liquid storage tank 1 and the second liquid storage tank 2. The first positive pressure source 12 pressurizes the first liquid storage tank 1. The atmospheric end 26 connects the second liquid storage tank 2 to the atmosphere. The first switching component 41 disconnects the second liquid storage tank 2 from the liquid application component 3 so that the first liquid storage tank 1 can fill the second liquid storage tank 2 with liquid.

[0128] The above description is merely a preferred embodiment of the present invention and should not be construed as limiting the scope of the invention. Those skilled in the art will understand that all or part of the processes for implementing the above embodiments, and equivalent variations made in accordance with the claims of the present invention, still fall within the scope of the invention.

Claims

1. A sample analyzer, characterized in that, include: The system includes a liquid supply assembly, a drive assembly, a sampling assembly, a reaction assembly, a detection assembly, a waste liquid treatment assembly, and a controller; the liquid supply assembly is used for liquid supply. The driving component is used to drive the flow path in the sample analyzer; the sampling component is used to collect and dispense biological samples; the reaction component is used to process the biological samples to form a test solution; the detection component is used to detect the test solution to form detection information; and the waste liquid treatment component is used to collect and discharge waste liquid from the sample analyzer. The controller is used to control the workflow of the sample analyzer and process the detection information to form analysis results; The liquid supply component includes a first liquid storage tank, a second liquid storage tank, and a liquid application component. Both the first liquid storage tank and the second liquid storage tank have a pool structure for containing liquid. The first liquid storage tank is connected to the second liquid storage tank, and the second liquid storage tank is connected to the liquid application component. When the liquid in the first liquid storage tank is insufficient, the second liquid storage tank supplies liquid to the liquid application component. A first switching element is provided between the second liquid storage tank and the liquid application component. The first switching element is used to connect or disconnect the second liquid storage tank and the liquid application component. A sixth switching component is also provided between the first liquid storage tank and the second liquid storage tank. The sixth switching component is used to connect or disconnect the first liquid storage tank and the second liquid storage tank, wherein the first liquid storage tank is connected to the liquid application component through the second liquid storage tank. When the first liquid storage tank supplies liquid to the second liquid storage tank, and then supplies liquid to the liquid-using component through the second liquid storage tank, the sixth switching element connects the first liquid storage tank and the second liquid storage tank, and the first switching element connects the second liquid storage tank and the liquid-using component. Liquid in the first liquid storage tank flows into the second liquid storage tank under the action of a pressure difference, and liquid in the second liquid storage tank flows into the liquid-using component under the action of a pressure difference. When the first liquid storage tank fills the second liquid storage tank, the sixth switching element connects the second liquid storage tank, and the first switching element disconnects the second liquid storage tank from the liquid-using component. Liquid in the first liquid storage tank flows into the second liquid storage tank under the action of a pressure difference. When the liquid in the first storage tank is insufficient and needs to be replenished, and the second storage tank supplies liquid to the liquid-using component, the sixth switching element disconnects the first storage tank and the second storage tank, and the liquid in the second storage tank flows into the liquid-using component under the action of pressure difference.

2. The sample analyzer as described in claim 1, characterized in that, The liquid supply assembly further includes a first positive pressure source and a first negative pressure source connected to the first liquid storage tank; when the first liquid storage tank supplies or fills the second liquid storage tank, the first positive pressure source pressurizes the first liquid storage tank; when the liquid in the first liquid storage tank is insufficient and filling is performed, the first negative pressure source depressurizes the first liquid storage tank.

3. The sample analyzer as described in claim 2, characterized in that, The liquid supply assembly further includes a second positive pressure source and a closed end connected to the second liquid storage tank. When the first liquid storage tank is filled with liquid, the second positive pressure source pressurizes the second liquid storage tank so that the second liquid storage tank supplies liquid to the liquid use assembly. When the first liquid storage tank supplies liquid to the second liquid storage tank and the second liquid storage tank supplies liquid to the liquid use assembly, the second liquid storage tank is connected to the closed end.

4. The sample analyzer as described in claim 3, characterized in that, The liquid supply assembly further includes a third switching component, which is disposed between the second positive pressure source and the second liquid storage tank. The third switching component is used to connect or disconnect the connection between the second liquid storage tank and the second positive pressure source.

5. The sample analyzer as described in claim 4, characterized in that, The liquid supply assembly further includes a seventh switching element and a second negative pressure source or atmospheric end. The seventh switching element is connected to the third switching element. The second positive pressure source, the closed end, and the second negative pressure source or atmospheric end are connected to the second liquid storage tank through the seventh switching element and the third switching element. When the first liquid storage tank fills the second liquid storage tank with liquid, the second negative pressure source reduces the pressure of the second liquid storage tank, or the atmospheric end connects the second liquid storage tank to the atmosphere.

6. The sample analyzer as described in claim 1, characterized in that, The volume of the first liquid storage tank is larger than that of the second liquid storage tank.

7. A liquid supply method for a sample analyzer, characterized in that, include: The first liquid storage tank supplies liquid to the liquid-using components; When the liquid in the first storage tank is insufficient, the second storage tank is used to supply liquid to the liquid-using component; A first switching element is provided between the second liquid storage tank and the liquid application component. The first switching element is used to connect or disconnect the second liquid storage tank and the liquid application component. A sixth switching component is also provided between the first liquid storage tank and the second liquid storage tank. The sixth switching component is used to connect or disconnect the first liquid storage tank and the second liquid storage tank, wherein the first liquid storage tank is connected to the liquid application component through the second liquid storage tank. When the first liquid storage tank supplies liquid to the second liquid storage tank, and then supplies liquid to the liquid-using component through the second liquid storage tank, the sixth switching element connects the first liquid storage tank and the second liquid storage tank, and the first switching element connects the second liquid storage tank and the liquid-using component. Liquid in the first liquid storage tank flows into the second liquid storage tank under the action of a pressure difference, and liquid in the second liquid storage tank flows into the liquid-using component under the action of a pressure difference. When the first liquid storage tank fills the second liquid storage tank, the sixth switching element connects the second liquid storage tank, and the first switching element disconnects the second liquid storage tank from the liquid-using component. Liquid in the first liquid storage tank flows into the second liquid storage tank under the action of a pressure difference. When the liquid in the first storage tank is insufficient and needs to be replenished, and the second storage tank supplies liquid to the liquid-using component, the sixth switching element disconnects the first storage tank and the second storage tank, and the liquid in the second storage tank flows into the liquid-using component under the action of pressure difference.

8. The liquid supply method as described in claim 7, characterized in that, The first liquid storage tank is connected to a first negative pressure source and a reagent tank. When the liquid in the first liquid storage tank is insufficient, a step of filling the first liquid storage tank with liquid is performed, including: The first liquid storage tank is connected to the reagent container, and the first negative pressure source reduces the pressure of the first liquid storage tank so that the liquid in the reagent container flows into the first liquid storage tank under the action of pressure difference.

9. The liquid supply method as described in claim 7, characterized in that, The second liquid storage tank is connected to the second positive pressure source, and the step of "the second liquid storage tank supplying liquid to the liquid-using component" includes: The second positive pressure source pressurizes the second liquid storage tank so that the liquid in the second liquid storage tank flows into the liquid application component.

10. The liquid supply method as described in claim 7, characterized in that, The first liquid storage tank is connected to a first positive pressure source, and the second liquid storage tank is connected to a second negative pressure source. When the liquid in the second liquid storage tank is insufficient, the liquid supply method further includes: The sixth switching element connects the first liquid storage tank and the second liquid storage tank, the first switching element disconnects the second liquid storage tank from the liquid application component, the first positive pressure source pressurizes the first liquid storage tank, and the second negative pressure source depressurizes the second liquid storage tank, so that the first liquid storage tank fills the second liquid storage tank with liquid.

11. The liquid supply method as described in claim 7, characterized in that, When the first and second liquid storage tanks are adequately filled with liquid, the liquid supply method further includes: The sixth switching element connects the first liquid storage tank and the second liquid storage tank. The first liquid storage tank supplies liquid to the second liquid storage tank, while the second liquid storage tank supplies liquid to the liquid-using component. The liquid level in the second liquid storage tank does not decrease.

12. The liquid supply method as described in claim 11, characterized in that, The liquid supply method further includes: When the first liquid storage tank is used to supply liquid to the second liquid storage tank, and the second liquid storage tank supplies liquid to the liquid-using component, the first positive pressure source pressurizes the first liquid storage tank, and the closed end seals the second liquid storage tank, so that the pressure inside the second liquid storage tank is constant.

13. The liquid supply method as described in claim 10, characterized in that, The second liquid storage tank can be switched between being connected to the atmosphere and being connected to a second negative pressure source. The liquid supply method further includes: During the process of filling the first liquid storage tank into the second liquid storage tank, the sixth switching component connects the first liquid storage tank and the second liquid storage tank, the first positive pressure source pressurizes the first liquid storage tank, the atmospheric end connects the second liquid storage tank to the atmosphere, and the first switching component disconnects the second liquid storage tank from the liquid application component.

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