Blood analysis device, system and method

Abstract

A method and apparatus for non-invasive blood analysis are provided. A blood analysis apparatus (10, 30) includes a housing (24) for receiving a human or animal body part or a blood container. The housing (24, 32) includes at least one wave transmitter (18) for transmitting a transmission wave toward target blood; and at least one wave sensor (26) for sensing a response wave after the transmission wave interacts with the target blood. The at least one wave sensor is configured to output at least one sensing signal, thereby allowing a spectrum of the transmission wave to be constructed.

Description

Technical Field

[0001] The present invention relates generally to blood analysis devices and, more particularly, to systems and methods for analyzing properties of blood. Background Art

[0002] The basic metabolic panel (BMP) is a blood test that includes a panel of, for example, seven or eight biochemical tests and is one of the most common laboratory tests ordered by health care providers. A version with seven tests is often referred to by medical professionals in the United States as "CHEM-7" or "SMA-7 (Sequential Multiple Analysis-7)." The seven sections of the CHEM-7 test for sodium (Na+), potassium (K+), chloride (Cl-), bicarbonate (HCO3-) or CO2, blood urea nitrogen (BUN), creatinine, and glucose.

[0003] Centrifuges are also used to separate blood components for blood analysis. For example, a hematocrit centrifuge is used to measure the volume percentage of red blood cells in whole blood.

[0004] Blood is often drawn from a patient's vein and sent to an outside laboratory for analysis. This existing process can take more time than desired in many cases.

[0005] Therefore, it is desirable to provide a blood analysis device, system, and method that is fast and convenient. In addition, it is desirable to provide a non-invasive option for blood analysis. Moreover, other desirable features and characteristics of the present invention will become apparent from the following detailed description of the invention and the appended claims, taken in conjunction with the accompanying drawings and this background of the invention. Summary of the Invention

[0006] In one aspect, a blood analysis device is provided, comprising a housing for receiving a human or animal body part or a blood container. The housing includes at least one wave transmitter for transmitting a transmission wave into a target blood, and at least one wave sensor for sensing a response wave after the transmission wave interacts with the target blood. The at least one wave sensor is configured to output at least one sensing signal, thereby allowing a spectrum of the transmitted wave to be constructed.

[0007] For example, the spectrum may include multiple narrowband frequency response components, a wideband response, or a high spectral response.

[0008] In another aspect, a blood analysis system includes a housing for receiving a human or animal body part or a blood container. The housing includes at least one magnetic resonance imaging (MRI) device for imaging the subject's blood, and an analyzer configured to receive the imaging from the MRI device and determine at least one blood characteristic of the subject's blood based on the imaging.

[0009] The blood analysis device disclosed herein is capable of performing blood tests without using traditional centrifugal filtration and separator methods to separate the different elements of a patient's blood to enable analysis of their plasma. The blood analysis device is capable of performing remote sensing blood analysis of a patient's plasma using imaging technologies such as ultrasound, magnetic resonance imaging (MRI), and hyperspectral imaging, which eliminates the need to physically tamper with the donor's blood.

[0010] Blood analysis devices can achieve higher analytical accuracy for donor blood because they can examine plasma in its natural state without centrifugal filtration. In ultrasound imaging embodiments, pressure waves are generated / emitted by at least one transducer / transmitter, which interact with target blood (e.g., plasma). Components of the target blood have unique frequency signatures that can be determined to analyze different targets of plasma and blood cells.

[0011] Ultrasonic pressure waves and other imaging techniques can also detect many abnormalities in blood and blood cell structure. By using imaging techniques and assigning frequency signatures to different target blood components, critical blood information can be gathered. In this way, highly time-efficient blood analysis results can be obtained.

[0012] In one embodiment, a combination of hyperspectral imaging and ultrasound imaging is used in blood analysis.

[0013] In an embodiment, the housing comprises a cuff for receiving a limb of a human or animal user.

[0014] In an embodiment, the housing comprises a receptacle for receiving and holding the container.In an embodiment, the housing comprises a gel forming the receptacle.

[0015] In an embodiment, the transmitted wave is an ultrasonic wave. In an embodiment, the ultrasonic wave is a broadband wave or a multi-spectral wave. In an embodiment, the broadband or multi-spectral ultrasonic imaging detection is performed by at least one wave sensor.

[0016] In an embodiment, the transmitted wave is an electromagnetic wave. In an embodiment, the electromagnetic wave is a broadband or multi-spectrum electromagnetic wave. In an embodiment, the broadband, multi-spectrum or high-spectrum electromagnetic imaging detection is performed by at least one wave sensor.

[0017] In an embodiment, the at least one wave sensor comprises a hyperspectral imaging sensor.

[0018] In an embodiment, the at least one wave launcher comprises a plurality of wave launchers and the at least one wave sensor comprises a plurality of wave sensors, such that at least two pairs of wave launchers and wave sensors are oppositely arranged around the housing.

[0019] In an embodiment, the at least one wave transmitter comprises at least one ultrasonic wave transmitter and at least one electromagnetic wave transmitter, and the at least one wave sensor comprises at least one ultrasonic wave sensor and at least one hyperspectral imaging sensor.

[0020] In an embodiment, the at least one wave sensor is configured to output spectral imaging of the target blood.

[0021] In another aspect, a blood analysis system is provided, comprising a blood analysis device as described herein and at least one blood analyzer configured for receiving at least one sensing signal and performing spectral analysis thereon and for determining at least one blood characteristic based on the spectral analysis.

[0022] In an embodiment, the at least one blood characteristic comprises at least one of: HDL - high density lipoprotein level, LDL - low density lipoprotein level, ratio of HDL to LDL, CRP - C-reactive protein level for body inflammation, CBC complete blood count, TSH - thyroid stimulating hormone level, INR - international normalized ratio, LFT - liver function test, U+E - urea and electrolytes, CMP - comprehensive metabolic panel, WBC - white blood cell count, RBC - red blood cell count, HBC - hemoglobin level of hemoglobin molecules, HCT - hematocrit level, PLT - platelet level, sodium, potassium, chloride, bicarbonate, blood urea nitrogen (BUN), magnesium, creatinine, glucose, and / or calcium, blood cell characteristics, blood cell wall thickness, blood cell quality, blood cell number, blood cell age, blood cell damage, blood minerals, immune cells, cancer cells, viruses, bacteria, blood pressure, triglyceride levels, carbon dioxide and / or oxygen levels, and blood flow rate.

[0023] In an embodiment, the at least one blood analyzer comprises at least one computer processor and computer processor instructions for performing the spectral analysis.

[0024] In an embodiment, at least one blood analyzer is included in the housing, provided remotely (eg, cloud-based), or a combination thereof.

[0025] In an embodiment, the at least one blood analyzer is configured to compare a spectral reading of the at least one sensed signal with at least one reference spectral signature corresponding to the at least one blood characteristic.

[0026] In another aspect, a blood analysis method includes providing a blood analysis device. The device includes a housing for receiving a human or animal body part or a blood container. The housing includes at least one wave transmitter and at least one wave sensor. The at least one transmitter transmits a transmission wave to a target blood. The at least one wave sensor senses a response wave generated after the transmission wave interacts with the target blood. The at least one wave sensor outputs at least one spectrum sensing signal. At least one blood analyzer receives the at least one spectrum sensing signal, performs spectrum analysis on the signal, and determines at least one blood characteristic based on the spectrum analysis.

[0027] In embodiments, the housing comprises a cuff for receiving a limb of a human or animal user, or wherein the housing comprises a receptacle for receiving and holding the container.

[0028] In an embodiment, the at least one wave sensor comprises at least one of a hyperspectral imaging sensor and an ultrasonic sensor.

[0029] In an embodiment, the spectrum analysis includes comparing the spectrum components of the at least one spectrum sensing signal with at least one reference spectrum feature corresponding to the at least one blood characteristic. For example, the spectrum analysis includes comparing normalized intensity values ​​at different frequency points in the at least one spectrum sensing signal with reference values ​​corresponding to the at least one reference spectrum feature.

[0030] In another aspect, a blood analysis method includes providing a blood analysis device. The device includes a housing for receiving a human or animal body part or a blood container. The housing includes an imaging device for imaging the target blood, such as an MRI. At least one blood analyzer receives the image from the imaging device, performs an image analysis on the image, and determines at least one blood characteristic based on the image analysis.

[0031] In yet another aspect, a blood analysis device is provided, comprising: at least one wave transmitter for transmitting a transmission wave toward target blood; and at least one wave sensor for sensing a response wave after the transmission wave interacts with the target blood. The at least one wave sensor is configured to output at least one sensing signal, thereby allowing a spectrum of the transmission wave to be constructed.

[0032] In another aspect, a blood analysis method includes providing a blood analysis device. The device includes a housing for receiving a human or animal body part or a blood container. The housing includes at least one wave transmitter and at least one wave sensor. The at least one transmitter transmits a transmission wave to a target blood. The at least one wave sensor senses a response wave generated after the transmission wave interacts with the target blood. The at least one wave sensor outputs at least one spectrum sensing signal. At least one blood analyzer receives the at least one spectrum sensing signal, performs spectrum analysis on the signal, and determines at least one blood characteristic based on the spectrum analysis.

[0033] In another aspect, a blood analysis system is disclosed, comprising:

[0034] at least one wave transmitter for transmitting a transmission wave toward target blood;

[0035] at least one wave sensor for sensing the response wave after the transmitted wave has interacted with the target blood. The at least one wave sensor is configured to output at least one sensing signal allowing the spectrum of the transmitted wave to be constructed, and

[0036] At least one blood analyzer is configured to receive the at least one sensing signal and perform spectral analysis thereon and determine at least one blood characteristic based on the spectral analysis.

[0037] In another aspect, a method of blood analysis is disclosed, the method comprising the steps of:

[0038] providing at least one wave transmitter and at least one wave sensor;

[0039] The at least one wave transmitter transmits a transmission wave toward the target blood;

[0040] The at least one wave sensor senses the response wave after the transmitted wave interacts with the target blood. The at least one wave sensor outputs at least one spectrum sensing signal;

[0041] At least one blood analyzer receives the at least one spectrum sensing signal; performs spectrum analysis on the at least one spectrum sensing signal; and determines at least one blood characteristic based on the spectrum analysis.

[0042] Preferably, the method comprises the steps of providing a blood analysis device having a housing operatively associated with the at least one wave transmitter, the housing being adapted to receive (i) a human or animal body part, or (ii) a blood container. BRIEF DESCRIPTION OF THE DRAWINGS

[0043] Hereinafter, the present invention will be described with reference to the following drawings, wherein like reference numerals denote like elements, and

[0044] Figure 1(a) to Figure 1(g) are different views of a first blood analysis device according to different embodiments;

[0045] Figure 2(a) to Figure 2(d) are different views of a second blood analysis device according to different embodiments;

[0046] FIG3( a ) is a flow chart of a blood analysis method according to various embodiments; and

[0047] FIG3( b ) is a flow chart of another method of blood analysis according to various embodiments. DETAILED DESCRIPTION

[0048] The following detailed description is merely exemplary in nature and is not intended to limit the invention or the application and uses of the invention. Furthermore, there is no intention to be bound by any theory presented in the preceding background or the following detailed description.

[0049] 1 and 2 , the present disclosure provides a blood analysis device 10 , 30 , comprising one or more imaging / sensing devices 18 , 26 for imaging blood contained in a vial 28 or other container or in vivo. In the embodiment according to FIG. 1 , the blood analysis device 10 is operable to stand on a table or other surface and receive a vial 28 of blood for imaging. In another embodiment according to FIG. 2 , the blood analysis device 30 forms a cuff and is operable to be wrapped around a limb (e.g., a patient's arm) for imaging blood in vivo. In these embodiments, blood is imaged, and the image is analyzed by an internal and / or external processing unit 22 , including an imaging analyzer, to determine blood characteristics. In some embodiments, ultrasound, MRI, and / or hyperspectral imaging is utilized. Imaging, as used herein, is broadly defined to refer to one or more sensing elements (e.g., a grid of pixels) for detecting ultrasonic, electromagnetic, or other waves and determining their intensity or other measurements. The sensed measurements can be collected and compared to reference values ​​that form a signature representing the blood characteristics. Thus, imaging may provide one or more measured features for comparison with a reference feature.

[0050] Steering Figure 1(a) to Figure 1(g), shows an embodiment of a first blood analysis device 10. The blood analysis device 10 includes a housing 24, which, in the exemplary embodiment, is barrel-shaped. The housing 24 has a bottom configured to stand on a horizontal surface, such as a table or desk. The housing 24 includes a plurality of imaging / sensing devices 18. Specifically, the imaging / sensing devices 18 include an ultrasonic transducer / emitter and an ultrasonic sensor. In the exemplary embodiment, three pairs of opposing imaging / sensing devices 18 are included. However, fewer or more imaging / sensing devices 18 may be included. The imaging / sensing devices 18 are distributed circumferentially around the housing 24 and secured thereto. The housing 24 also includes different types of imaging / sensing devices 26, which, in the exemplary embodiment, are high-spectrum imaging devices. By providing a combination of different types of imaging / sensing devices 18, 26, more information about the target blood can be used for subsequent analysis and blood characterization. Although a combination of ultrasonic and high-spectrum imaging / sensing devices 18, 26 is disclosed in this embodiment, other imaging / sensing media that allow for determination of blood properties are contemplated, such as a miniature MRI device. In one embodiment, the interior space defined by the housing 24 is filled with solid silicone gel to reduce ultrasonic pressure wave impedance.

[0051] In an embodiment, the hyperspectral imaging / sensing device 26 includes multiple LED lights to facilitate hyperspectral imaging. The high-spectrum electromagnetic waves are captured by the hyperspectral camera for subsequent analysis. In an embodiment, the processing unit 22 is configured to activate one ultrasound imaging / sensing device (transducer / emitter 18) to emit ultrasound pressure waves and, after the emitted waves have interacted with the target blood in the vial 28, use multiple other ultrasound imaging / sensing devices (sensors 18) to sense the emitted waves. In this way, the loss of ultrasound imaging information is minimized.

[0052] exist Figure 1(a) to Figure 1(g)In some embodiments, the imaging / sensing devices 18, 26 are arranged on a frame 20 that supports the imaging devices and also allows imaging / sensing data to be transmitted therein to a processing unit 22. In some embodiments, the processing unit 22 is configured to receive and externally transmit the captured imaging / sensing data for external analysis. In other embodiments, the processing unit 22 is configured to analyze the captured imaging / sensing data to determine blood characteristics. In some embodiments, the processing unit 22 includes a microprocessor or other computer processor device and a memory on which instructions for controlling the operation of the imaging / sensing devices 18, 26 are stored. Specifically, the processing unit 22 is configured to activate the imaging / sensing devices 18, 26 to capture imaging / sensing data and transmit the captured (and optionally pre-processed) imaging / sensing data for blood analysis processing at an external blood analyzer, or to analyze onboard imaging / sensing data to determine blood characteristics. In some embodiments, blood analysis of the imaging / sensing data includes comparing the imaging / sensing data with a database of blood imaging / sensing characteristics to determine the blood characteristics. In embodiments utilizing ultrasound and / or hyperspectral imaging / sensing, spectral components of the imaging / sensing data are compared to spectral imaging / sensing data stored in a reference database to characterize the blood.

[0053] Figure 1(a) to Figure 1(g) The blood analysis device 10 of the exemplary embodiment includes a cover 12 that allows the housing 24 to be closed during activation of the imaging / sensing devices 18, 26. In the exemplary embodiment shown, the first cover 12a and the second cover 12b are opened and closed by sliding on the top of the housing 24. The specific mechanism shown is the sliding fit of the housing 24 and the brackets 14, 15 of the cover 12, and the sliding fit of the protrusions and guides 16, 17 between the housing 24 and the cover 12. Other cooperative structures are envisioned for allowing the first cover 12a and the second cover 12b to slide away and toward each other when opening and closing. In addition, alternative opening and closing structures, such as hinges, etc., can be provided to allow vertical opening and closing. In the exemplary embodiment of Figure 1, the cover 12 is opened and closed by manual operation. However, an electrified (e.g., motor-operated) cover 12 is possible.

[0054] The blood analysis device 10 may comprise a (rechargeable) battery for powering the imaging / sensing devices 18, 26. Alternatively, a power cord socket for the power supply may be included.

[0055] refer to Figure 2(a) to Figure 2(d), shows an embodiment of a second blood analysis device 30. The blood analysis device 30 includes a cuff-shaped housing 32 for wrapping around a subject's limb, such as an upper arm. The housing 32 includes a first housing portion 48a and a second housing portion 48b, which are connected at a hinge 42 to allow the housing 32 to open to receive the upper arm and close around the upper arm. The housing 32 includes a latch 34 to retain the housing 32 in a closed configuration. The latch 34 includes a first arm 36 and a second arm 44 connected at the ends of the respective housing portions 48a and 48b. The second arm 44 includes a plate 39 connected thereto, and the plate 39 has a plurality of ribs 40 that, when engaged by the first arm 36, define different degrees of closure for the housing 32. A release tab 41 is included on the exterior of the plate 39 to facilitate releasing the latch 34 to open the housing 32. Thus, the latch 34 has different latching positions (provided by the rib 40 in one embodiment) so that the housing 32 can accommodate upper arms of different sizes.

[0056] In an embodiment, the housing 32 holds a plurality of imaging / sensing devices 38, 46. In some embodiments, different types of imaging / sensing devices 38, 46 are included in the housing 32. In one exemplary embodiment, one or more ultrasound devices 38 are included, and one or more high-frequency imaging / sensing devices 46 are included. MRI imaging and other suitable imaging / sensing media may be used. The imaging / sensing devices 38, 46 are directed toward the interior of the cuff-shaped housing to image / sens blood flowing within a subject's vein.

[0057] Despite Figure 2(a) to Figure 2(d) Although not shown, the processing unit 32 is included in the housing 32 for controlling the activation of the imaging / sensing devices 38, 46 and for controlling the capture of imaging / sensing data. The processing unit is configured to process the imaging / sensing data to determine blood characteristics or transmit the captured imaging / sensing data (optionally after pre-processing) to an external processor for analysis to determine blood characteristics. In addition, the blood analysis device 30 includes a battery (e.g., a rechargeable battery) for powering the imaging / sensing devices 38, 46 and the processing unit.

[0058] FIG3 is a flow chart of one exemplary operation of the blood analysis devices 10 , 30 described herein.

[0059] Steps 100 and 102 relate to the blood analysis device 10 of FIG. 1 . In step 100 , a barcode on a vial or test tube 28 is scanned by a barcode scanner (not shown), which may be internal to the blood analysis device 10 or a peripheral device. Other ways of uniquely identifying the vial 28 are contemplated, such as a QR code and an alphanumeric serial code. In step 102 , the vial 28 containing the target blood is inserted into a receptacle defined by the silicone gel included within the housing 24 . Thus, the lid 12 slides open horizontally relative to the housing 24 . For the blood analysis device 30 of FIG. 2 , steps 100 and 102 are replaced by placing the housing 32 around the subject's arm or leg and engaging the latch 34 at a latch position corresponding to a close fit of the housing 32 with the subject's body part. The remaining steps of the flowchart of FIG. 3 are common to both blood analysis devices 10 and 30 .

[0060] Step 104 includes activating the imaging / sensing devices 18, 26, 38, 46. In some embodiments, activating the imaging / sensing devices 18, 26, 38, 46 includes emitting ultrasound waves from one or more ultrasound imaging / sensing devices 18, 38 in sub-step 104a. Additionally or alternatively, activating the imaging / sensing devices 18, 26, 38, 46 includes emitting electromagnetic radiation from the hyperspectral imaging devices 26, 46 in sub-step 104b. In step 106, imaging / sensing data of the target blood is captured using the sensors 18, 26, 38, 46. In some embodiments, capturing imaging / sensing data includes step 106b, which uses the hyperspectral imaging cameras / sensors 26, 46 to capture hyperspectral data that has interacted with the blood. Additionally or alternatively, in step 106b, the ultrasound sensors / cameras 18, 38 are used to detect ultrasound pressure waves that have interacted with the target blood. In step 108 , the plurality of imaging / sensing devices 18 , 26 , 38 , 46 are sequentially activated, and imaging data is captured from one or more of the imaging sensing devices 18 , 26 , 38 , 46 .

[0061] In step 110, the imaging data that has been captured in the previous steps is processed. In one embodiment, step 110 includes transmitting the captured imaging / sensing data to an external processor or performing processing using the processing unit 22. The transmission of the imaging / sensing data can use WiFi, Bluetooth, Zigbee, or any other data transmission scheme. Processing is performed on the captured imaging / sensing data. In one example, spectrally focused (e.g., narrowband focused) imaging / sensing data is identified that corresponds to a known feature of a blood property. One or more spectral filters can be used to spectrally focus the captured imaging data. In an embodiment, the processing step 110 generates a plurality of spectrally focused imaging / sensing data components corresponding to the known features of the blood property. For example, step 110 includes providing normalized intensity values ​​at different frequency points in the measurement data for comparison with reference values ​​corresponding to features of a specific blood property in step 112 (described below).

[0062] In step 112, the spectrally focused imaging data is compared with reference signature data obtained from a reference database 111 (which may be periodically updated from a cloud 113). That is, a reference imaging / sensing signature (e.g., a narrowband signature) comprising data points at a plurality of specific frequencies is compared with the imaging / sensing data from step 110 having data points at corresponding specific frequencies to determine matching data indicative of blood characteristics. In this manner, blood characteristics as described herein are determined in step 116.

[0063] In step 118, the blood analysis results from step 116 are stored and reported. In one example, a cloud-based results database is accessed to retrieve the blood analysis, for example using a unique code (e.g., as obtained from a barcode) associated with the patient or vial 28. In an embodiment, the blood analysis report is printed on physical media or displayed on a screen.

[0064] FIG3( b) shows another exemplary embodiment of blood analysis using an MRI method. MRI data capture may be used in addition to or alternatively to the ultrasound or high-frequency spectrum sensing methods described above with respect to FIG3( a). The method is substantially the same as the method described with respect to FIG3( a). As such, the process will not be further described except for steps 104', 106', 110', and 112'. In these steps, MRI data capture (step 106') is used for target blood in a vial or in a patient's limb. Different aspects of the MRI data (e.g., measurements at different frequency combinations) are grouped into measurement features for comparison with reference features in steps 110' and 112' to determine the value of the corresponding blood property. Thus, the blood analysis value is determined in step 116' and reported in step 118'.

[0065] In a non-illustrated embodiment, a blood analysis device is disclosed for use in a doctor's waiting room and adapted to perform diagnostics on patients in the waiting room. The blood analysis device can be placed on a receiving table or mounted to a wall, for example. The blood analysis device includes at least one wave transmitter for transmitting a transmission wave toward a patient (target blood); and at least one wave sensor, in this case a hyperspectral imaging sensor, for sensing a response wave after the transmission wave interacts with the patient in the waiting room. The at least one wave sensor is configured to output at least one sensing signal, thereby allowing the construction of a spectrum of the transmission wave. In this embodiment, the patient's blood is imaged, and the image is analyzed by a processing unit including an imaging analyzer to determine blood characteristics. In this embodiment, hyperspectral imaging is used to detect the waves and determine their intensity or other measured values. These sensed measured values ​​are collected and compared with reference values ​​that form characteristics representative of the blood characteristics. Thus, the imaging can provide one or more measured characteristics for comparison with the reference characteristics, enabling the detection of diseases while the patient is waiting in the waiting room. It should be understood that the use of the blood analysis device is not necessarily limited to doctor's waiting rooms but can also be used in public spaces and for detecting diseases in animals.

[0066] Although at least one exemplary aspect has been presented in the foregoing detailed description of the present invention, it will be appreciated that there are a large number of variations. It will also be appreciated that one or more exemplary aspects are merely examples and are not intended to limit the scope, applicability, or configuration of the present invention in any way. On the contrary, the foregoing detailed description will provide a convenient roadmap for those skilled in the art to implement the exemplary aspects of the present invention. It will be appreciated that various changes may be made to the functions and arrangements of the elements described in the exemplary aspects without departing from the scope of the present invention as set forth in the appended claims.

Claims

1. A blood analysis device comprising: a housing operatively associated with a plurality of imaging / sensing devices, the plurality of imaging / sensing devices being respectively configured with at least one wave transmitter and at least one wave sensor; Wherein, the housing is adapted to: a cuff operable to be wrapped around a limb of a human or animal body part, or a barrel-shaped receiver for receiving and holding a blood container; The at least one wave transmitter transmits a transmission wave toward the limb of the human or animal body part or the target blood in the container, and the at least one wave sensor sensing a response wave after the transmission wave interacts with the target blood, the at least one wave sensor being configured to output at least one sensing signal allowing construction of a spectrum of the response wave; as well as a processing unit comprising a spectrum analyzer configured to determine blood characteristic data and compare with reference values ​​to determine blood characteristics for external analysis, wherein the processing unit is configured to wirelessly receive and externally transmit the blood characteristics, and The cuff comprises: a first housing portion and a second housing portion, the first housing portion and the second housing portion being connected at a hinge to allow the housing to open to receive the limb of the human or animal body part and to close around the limb; a latch that retains the housing in the closed configuration, the latch comprising first and second arms connected at ends of respective first and second housing portions; the second arm comprising a plate having a plurality of ribs defining varying degrees of closure of the housing when engaged by the first arm; and A release tab is included on the exterior of the plate to facilitate releasing the latch to open the housing.

2. The blood analyzer according to claim 1, wherein The receiver is filled with solid silicone gel to reduce ultrasound pressure wave impedance.

3. The blood analyzer according to claim 1, wherein The transmitted wave is an ultrasonic wave.

4. The blood analyzer according to claim 3, wherein: The ultrasonic waves are broadband waves or multi-spectrum waves.

5. The blood analyzer according to claim 1, wherein The transmitted waves are electromagnetic waves.

6. The blood analyzer according to claim 5, wherein: The electromagnetic wave is a broadband wave or a multi-spectrum electromagnetic wave.

7. The blood analyzer according to claim 1, wherein The at least one wave sensor comprises a hyperspectral imaging sensor.

8. The blood analyzer according to claim 1, wherein The at least one wave launcher includes a plurality of wave launchers, and the at least one wave sensor includes a plurality of wave sensors, such that at least two pairs of wave launchers and wave sensors are oppositely arranged around the housing.

9. The blood analyzer according to claim 1, wherein The at least one wave transmitter includes at least one ultrasonic wave transmitter and at least one electromagnetic wave transmitter, and the at least one wave sensor includes at least one ultrasonic wave sensor and at least one hyperspectral imaging sensor.

10. The blood analyzer according to claim 1, wherein The at least one wave sensor is configured to output a spectrum image of the target blood.

11. A blood analysis system comprising: A blood analysis apparatus according to any preceding claim, said blood analysis apparatus having at least one blood analyser comprising at least one computer processor and computer processor instructions for performing said spectral analysis; as well as The at least one blood analyzer is configured to receive the at least one sensing signal and perform spectral analysis thereon and determine at least one blood characteristic based on the spectral analysis; wherein the at least one blood analyzer is configured to compare a spectral reading of the at least one sensing signal with at least one reference spectral signature corresponding to the at least one blood characteristic, wherein the computer processor is configured to wirelessly receive and externally transmit the spectrum reading of the at least one sensing signal; and Therein, the spectrum reading of the at least one sensing signal is compared with reference signature data obtained from a reference database that is regularly updated from the cloud.

12. The blood analysis system according to claim 11, wherein: The at least one blood characteristic comprises at least one of the following: HDL-high-density lipoprotein levels; LDL-low-density lipoprotein levels; The ratio of HDL to LDL; CRP - C-reactive protein level for inflammation in the body; CBC-complete blood count; TSH-thyroid stimulating hormone level; INR-International Normalized Ratio; LFT-liver function test; U+E-urea and electrolytes; CMP-comprehensive metabolic profile; WBC-white blood cell count; RBC-red blood cell count; HBC - hemoglobin levels of hemoglobin molecules; HCT-hematocrit level; PLT-platelet level; sodium, potassium, chloride, bicarbonate, blood urea nitrogen (BUN), magnesium, creatinine, glucose, and / or calcium; blood cell characteristics; blood cell wall thickness; Blood cell quality; blood cell count; Blood cell age; Blood cell damage Blood minerals; Immune cells ·cancer cell; ·Virus; ·bacteria; ·blood pressure; triglyceride levels; Carbon dioxide and / or oxygen levels; and Blood flow velocity.

13. The blood analysis system according to claim 11, wherein: The at least one blood analyzer is included in the housing or remotely included, or a combination thereof.

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