A sample analysis device and a sample analysis method

Abstract

A sample analysis device and a sample analysis method, comprising one or more reagent dispensing components (60), the number of the reagent dispensing components (60) being equal to the number of processing units (50); each reagent dispensing component (60) comprising: a plurality of reagent needles (61), a guide component (62) for guiding the plurality of reagent needles (61) to perform linear motion, and a second drive component (63) for driving the plurality of reagent needles (61) to perform linear motion along the guide component (62); the guide component (62) being arranged along a direction determined by a reagent aspirating position and a reagent adding intermediate transfer position of a processing unit (50) corresponding to the reagent dispensing component (60), so that the reagent needle (61) aspirates the reagent from the reagent aspirating position and discharges the reagent into a reaction cup at the reagent adding intermediate transfer position of the processing unit (50) corresponding to the reagent dispensing component (60).

Description

Technical Field

[0001] The invention relates to a sample analysis device and a sample analysis method. Background Art

[0002] Sample analysis devices, such as biochemical analyzers, immunoassay analyzers, coagulation analyzers and cell analyzers, are instruments used to analyze and measure samples. Generally, reagents are added to the samples, and the characteristics, chemical composition and concentration of the samples after the reaction with the reagents are measured in a certain way.

[0003] Improving the test speed of the sample analysis device is a goal pursued by technicians; miniaturization of the sample analysis device is also one of the goals pursued by technicians; in order to improve the test speed of the sample analysis device, one idea is to add related components, such as multiple sample needles, etc., but adding related components will increase the volume of the instrument, which is contrary to the goal of miniaturization of the instrument pursued by technicians. Therefore, how to solve or balance the contradiction between speed-up and miniaturization of the sample analysis device is the goal of the present invention. Summary of the invention

[0004] The present invention mainly provides a sample analysis device and a sample analysis method, which are described in detail below.

[0005] According to a first aspect, a sample analysis device comprises:

[0006] chassis;

[0007] A reaction cup loading component, used for supplying and carrying empty reaction cups;

[0008] The sample introduction component is used to dispatch the sample rack carrying the sample to the sample suction position;

[0009] The sample dispensing component is used to absorb the sample from the sample suction position and discharge it into the reaction cup located at the sample adding position;

[0010] A reagent carrying component, the reagent carrying component is arranged in a disc-shaped structure, and has a plurality of positions for a first reagent container for carrying a first reagent, and a plurality of positions for a second reagent container for carrying a second reagent; the reagent carrying component includes a first driving component for driving the rotation thereof, the first driving component drives the reagent carrying component to rotate and drives the first reagent container to rotate, so as to rotate the first reagent container to a first reagent suction position; the first driving component drives the reagent carrying component to rotate and drives the second reagent container to rotate, so as to rotate the second reagent container to a second reagent suction position;

[0011] A reaction component, used for carrying a reaction cup and incubating the sample in the reaction cup, wherein the reaction component is provided with at least one incubation transfer position for placing the reaction cup;

[0012] A measuring component, used for carrying a reaction cup and detecting a sample in the reaction cup, wherein the measuring component is provided with at least one measuring transfer position for placing the reaction cup;

[0013] The first reagent dispensing component includes: a first crossbeam and a first group of reagent needles, wherein the first group of reagent needles includes at least a plurality of first reagent needles; the plurality of first reagent needles are arranged on the first crossbeam and move linearly along the long axis direction of the first crossbeam to absorb the first reagent from the first reagent aspiration position and discharge it into the reaction cup located at the incubation transfer position;

[0014] The second reagent dispensing component includes: a second crossbeam and a second group of reagent needles, the second group of reagent needles includes at least a plurality of second reagent needles; the plurality of second reagent needles are arranged on the second crossbeam and move linearly along the long axis direction of the second crossbeam to absorb the second reagent from the second reagent aspiration position and discharge it into the reaction cup located at the measurement transfer position;

[0015] The scheduling component is used to schedule the reaction cups; the scheduling component schedules the reaction cups with the first reagent added at the incubation transfer position to the reaction component, and schedules the reaction cups with the second reagent added at the measurement transfer position to the measurement component.

[0016] According to the second aspect, an embodiment provides a sample analysis device, comprising:

[0017] A reaction cup loading component, used for supplying and carrying empty reaction cups;

[0018] The sample introduction component is used to dispatch the sample rack carrying the sample to the sample suction position;

[0019] The sample dispensing component is used to absorb the sample from the sample suction position and discharge it into the reaction cup located at the sample adding position;

[0020] A reagent carrying component, which carries a reagent container and is capable of rotating and rotating the reagent container to a reagent suction position;

[0021] One or more processing units; the processing units are used to receive a cuvette carrying a sample and process the sample in the cuvette; each processing unit is configured with a corresponding reagent transfer position;

[0022] One or more reagent dispensing components, the number of which is equal to the number of processing units, and one reagent dispensing component corresponds to one processing unit; each reagent dispensing component comprises: a plurality of reagent needles, a guide assembly for guiding the plurality of reagent needles to make linear motion, and a second driving assembly for driving the plurality of reagent needles to make linear motion along the guide assembly; the guide assembly is arranged along a direction determined by a reagent aspirating position and a reagent adding intermediate transfer position of the processing unit corresponding to the reagent dispensing component, so that the reagent needle absorbs the reagent from the reagent aspirating position and discharges it into a reaction cup at the reagent adding intermediate transfer position of the processing unit corresponding to the reagent dispensing component; and

[0023] The scheduling component is used to schedule the reaction cups that have completed the sample loading and are located in the sample loading position to each processing unit according to the detection process.

[0024] According to a third aspect, an embodiment provides a sample analysis method, comprising the following steps:

[0025] A reaction cup loading step, controlling the reaction cup loading component to supply and carry the empty reaction cup;

[0026] A sample feeding step, controlling the sample feeding component to dispatch the sample rack carrying the sample to the sample suction position;

[0027] The sample dispensing step controls the sample dispensing component to absorb the sample from the sample aspiration position and dispense it into the reaction cup;

[0028] The first reagent dispensing step comprises controlling the driving component to drive the reagent carrying component to rotate so that the reagent container carrying the first reagent is located at the first reagent aspirating position; controlling at least one of the two reagent needles on the first reagent dispensing component to aspirate the first reagent in the reagent container through the first reagent aspirating position, and to make a linear motion between the first reagent aspirating position and the reagent adding intermediate transfer position of the reaction component, so as to dispense the first reagent into the reaction cup at the reagent adding intermediate transfer position of the reaction component;

[0029] Incubation step, controlling the scheduling component to schedule the reaction cup after the first reagent is dispensed to the reaction component for incubation, and scheduling the reaction cup after the incubation to the reagent adding transfer position of the measurement component;

[0030] The second reagent dispensing step comprises controlling the reagent carrying component to rotate so that the reagent container carrying the second reagent is located at the second reagent aspirating position; controlling at least one of the two reagent needles on the second reagent dispensing component to aspirate the second reagent in the reagent container through the second reagent aspirating position, and to make a linear motion between the second reagent aspirating position and the reagent adding intermediate transfer position of the measuring component, so as to dispense the second reagent into the reaction cup at the reagent adding intermediate transfer position of the measuring component;

[0031] In the determination and recovery step, the control scheduling component dispatches the reaction cup after the second reagent is dispensed to the determination component for project detection, and dispatches the reaction cup after the detection to the waste recovery device. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 is a schematic structural diagram of a sample analysis device according to an embodiment;

[0033] Figure 2 is a schematic structural diagram of a sample analysis device according to another embodiment;

[0034] Figure 3 is a schematic structural diagram of a sample analysis device according to another embodiment;

[0035] FIG. 4 (a) and FIG. 4 (b) are schematic structural diagrams of reagent carrying components of two embodiments;

[0036] Figure 5 A schematic structural diagram of a reagent carrying component in another embodiment;

[0037] Figure 6 It is a structural schematic diagram of a sample analysis device according to another embodiment;

[0038] Figure 7 A schematic diagram of the structure of a reagent dispensing component according to an embodiment;

[0039] Figure 8 A schematic diagram of the structure of a reagent dispensing component in another embodiment;

[0040] Fig. 9 A schematic structural diagram of a reagent dispensing component in yet another embodiment;

[0041] Fig.10 A schematic diagram of the structure of a reagent dispensing component according to another embodiment;

[0042] Fig.11 It is a structural schematic diagram of a sample analysis device according to another embodiment;

[0043] FIG12(a) is a schematic diagram of the structure of a transfer component according to an embodiment, FIG12(b) is a schematic diagram of the structure of a first transfer component according to an embodiment, FIG12(c) is a schematic diagram of the structure of a second transfer component according to an embodiment, and FIG12(d) is a schematic diagram of the structure of a third transfer component according to an embodiment;

[0044] Fig.13 A schematic diagram of the structure of a cup gripper according to an embodiment;

[0045] Fig.14 It is a structural schematic diagram of a sample analysis device according to yet another embodiment;

[0046] Fig.15 is a schematic structural diagram of a sample analysis device according to yet another embodiment;

[0047] Fig.16 A schematic diagram of the structure of a cleaning component according to an embodiment;

[0048] Fig.17 A schematic diagram of a sample analysis method according to an embodiment of the present invention;

[0049] Fig.18 A timing action diagram of two reagent needles in the same group in one embodiment;

[0050] Fig.19 A timing action diagram of two reagent needles in the same group in yet another embodiment;

[0051] Fig. 20 A timing action diagram of two reagent needles in the same group in another embodiment;

[0052] Fig.21 A timing action diagram of two reagent needles in the same group in yet another embodiment;

[0053] Fig. 22 A method of a sample analysis device according to an embodiment of the present invention is provided. DETAILED DESCRIPTION

[0054] The present invention is further described in detail below by specific embodiments in conjunction with the accompanying drawings. Wherein similar elements in different embodiments adopt associated similar element numbers. In the following embodiments, many detailed descriptions are for making the present invention better understood. However, those skilled in the art can easily recognize that some features can be omitted in different situations, or can be replaced by other elements, materials, methods. In some cases, some operations related to the present invention are not shown or described in the specification, this is to avoid the core part of the present invention being overwhelmed by too much description, and for those skilled in the art, it is not necessary to describe these related operations in detail, and they can fully understand the related operations according to the description in the specification and the general technical knowledge in the art.

[0055] In addition, the features, operations or characteristics described in the specification can be combined in any appropriate manner to form various implementations. At the same time, the steps or actions in the method description can also be interchanged or adjusted in a manner that is obvious to those skilled in the art. Therefore, the various sequences in the specification and the drawings are only for the purpose of clearly describing a certain embodiment and are not meant to be a required sequence, unless otherwise specified that a certain sequence must be followed.

[0056] The serial numbers assigned to the components herein, such as "first", "second", etc., are only used to distinguish the objects described and do not have any order or technical meaning. The "connection" and "coupling" mentioned in the present invention include direct and indirect connections (couplings) unless otherwise specified.

[0057] The structures of sample analysis devices according to some embodiments of the present invention are described below.

[0058] The sample analysis device is an instrument used to analyze and measure samples. Let's take the coagulation analyzer as an example to illustrate the test process of the sample analysis device. The test process of the coagulation analyzer is generally as follows: add the sample and reagent to the reaction cup to prepare a reaction solution, mix and incubate the reaction solution, and then place the reaction cup in the measurement component. The measurement component can irradiate the reaction solution in the reaction cup with multi-wavelength light, and analyze it through coagulation method, immunoturbidimetry or chromogenic substrate method to obtain the coagulation reaction curve of the reaction solution over time, so as to further calculate the coagulation time or other coagulation-related performance parameters of the reaction solution. Since the coagulation analyzer is used to obtain the coagulation reaction curve of the reaction solution over time, in order to obtain the correct measurement results, the time boundary conditions such as the addition time and incubation time of the sample and reagent need to be strictly set and controlled in the test process.

[0059] Please refer to Figure 1 , is a schematic diagram of the structure of a sample analysis device in some embodiments of the present invention. The sample analysis device in some embodiments of the present invention may include a housing 1, a cuvette loading component 10, a sample component 20, a sample dispensing component 30, a reagent carrying component 40, one or more reagent dispensing components 60, one or more processing units 50 and a scheduling component 70. It should be noted that, Figure 1 The example shown in FIG. 1 is a sample analyzer having two reagent dispensing components 60 and two processing units 50, but those skilled in the art will appreciate that this is only for illustration and does not limit the number of reagent dispensing components 60 and processing units 50 to only two. The following is a detailed description of each component in the sample analyzer.

[0060] The housing 1 is an instrument housing of the sample analysis device, for example, it may have a substantially rectangular or cube-shaped box shape, and its function may be to store some components of the sample analysis device. For example, in some embodiments, the housing 1 includes a first side 1a along a first direction and a second side 1b along a second direction.

[0061] The first direction and the second direction involved in this document, in some embodiments, these two directions, namely the first direction and the second direction, may be perpendicular to each other, for example, the first direction is the Y direction in the figure, and the second direction is the X direction in the figure.

[0062] The cuvette loading component 10 is used to supply and carry empty cuvettes. During operation, the sample analysis device needs to continuously use empty cuvettes to complete test items one by one. The sample analysis device prepares, incubates and measures the reaction solution by adding samples and reagents to the empty cuvettes, thereby obtaining the test results of the items. The cuvette loading component 10 can load the empty cuvettes to a predetermined position, and the sample dispensing mechanism draws the sample from the sample component 20 and discharges it into the empty cuvette at the predetermined position.

[0063] The sample component 20 is used to supply a sample rack carrying samples to be tested. In some embodiments, the sample component 20 can be disposed in the housing 1. The sample component 20 can be implemented in a variety of ways.

[0064] In one implementation of the sample component 20 , the sample component 20 may be a sample injection component 21 , and the sample injection component 21 is used to dispatch a sample rack carrying a sample to a sample suction position. Figure 2 As an example, the injection component 21 may include a loading area 21a, an injection channel 21b and an unloading area 21c, wherein the injection channel 21b may be provided with a sample suction position 21d. In the figure, the X direction and the Y direction are perpendicular, the X1 direction and the X2 direction are opposite directions, and the Y1 direction and the Y2 direction are also opposite directions. The user can place the sample rack carrying the sample to be tested in the loading area 21a, and the loading area 21a moves the sample rack in the Y1 direction in the figure to enter the injection channel 21b. The sample rack can move along the X1 direction in the injection channel 21b and pass through the sample suction position. The sample on the sample rack can be sucked by the sample dispensing component 30 when passing through the sample suction position. The sample rack then enters the unloading area 21c from the injection channel 21b along the Y2 direction, and the user can take out the sample rack from the unloading area 21c. The sampling component 21 is more suitable for large-scale sample testing occasions, and the sampling component 21 can be set independently from the sample analysis device. When the sample analysis device needs to be connected to a test system in the form of an assembly line, the sampling component 21 can be directly removed.

[0065] In another implementation of the sample component 20 , the sample component 20 may be a sample placement area 22 , and the sample placement area 22 is used to place a sample rack carrying samples to be tested. Figure 3 is an example. The sample placement area 22 may have multiple channels 22a, each channel 22a may hold a sample rack, and the user may push the sample rack into the channel 22a along the Y1 direction in the figure; the sample dispensing component 30 may absorb the samples on the sample racks in each channel 22a in turn; after all the samples on the sample racks are absorbed, the user may pull the sample rack out of the channel 22a along the Y2 direction in the figure. The sample placement area 22 does not require the sample rack to be arranged, so it occupies a small volume, which is conducive to reducing the size of the sample analysis device, and is very beneficial to the miniaturization design of the sample analysis device.

[0066] The sample dispensing component 30 is used to draw the sample from the sample suction position and discharge it into the reaction cup located at the sample loading position. In some embodiments, the sample dispensing component 30 can be arranged in the housing 1. In some embodiments, the sample dispensing mechanism 30 may include a sample needle, and the sample needle is driven by a two-dimensional or three-dimensional driving mechanism to move in a two-dimensional or three-dimensional direction. In some embodiments, the sample needle may be one or more. In order to simplify the motion trajectory and reduce the volume and size of the sample analysis device, the sample suction position and the predetermined position where the reaction cup loading component 10 loads the empty reaction cup can be designed to be on a straight line, for example, on a straight line along the first direction, so that the sample needle only needs to reciprocate between the sample suction position and the above-mentioned predetermined position in the first direction, which not only increases the movement speed of the sample needle, but also helps to reduce the size of the sample analysis device, which is very beneficial for the miniaturized design of the sample analysis device.

[0067] The reagent carrying component 40 is used to carry reagents. For example, the reagent carrying component 40 can have multiple positions for carrying reagent containers, and the reagent containers are used to carry reagents. Generally, the reagent carrying component 40 can provide functions such as refrigeration for the carried reagents, thereby ensuring the activity of the reagents. In some embodiments, the reagent carrying component 40 can be arranged in the housing 1. In some embodiments, the reagent carrying component 40 is arranged in a disc-shaped structure, which has multiple positions for carrying reagent containers. The reagent carrying component 40 can rotate and drive the reagent container it carries to transport, thereby rotating the reagent container to the reagent suction position for the reagent dispensing component 60 to absorb the reagent-for example, the reagent carrying component 40 includes a first drive component for driving its rotation, and the first drive component drives the reagent carrying component 40 to rotate, which is used to rotate the reagent container to the reagent suction position. The reagent carrying component 40 arranged in a disc-shaped structure is specifically described below.

[0068] Please refer to Figure 4 (a). In some specific embodiments, the reagent carrying component 40 is arranged in a disc-shaped structure, which has a plurality of positions for placing reagent cups 41. The reagent cups 41 each include one or more cavities for holding reagents required for project testing, and one reagent is placed in one cavity; the reagent carrying component 40 includes a first driving component for driving it to rotate, and the first driving component drives the reagent carrying component 40 to rotate, and is used to rotate the cavity of the reagent cup 41 containing the reagent required for the project to the corresponding reagent suction position. In one example, the reagent cup 41 includes at least a first cavity 41a for carrying a first reagent and a second cavity 41b for carrying a second reagent. For example, the reagent cup 41 includes at least a first cavity 41a for carrying a mixed reagent R1 and a second cavity 41b for carrying a trigger reagent R2; the reagent carrying component 40 includes a first reagent aspiration position and a second reagent aspiration position different from the first reagent aspiration position, and the first driving component drives the reagent carrying component 40 to rotate and drives the reagent cup 41 to rotate, so as to rotate the first cavity 41a of the reagent cup 41 to the first reagent aspiration position; the first driving component drives the reagent carrying component 40 to rotate and drives the reagent cup 41 to rotate, so as to rotate the second cavity 41b to the second reagent aspiration position.

[0069] Please refer to FIG. 4 (b). In some specific embodiments, the reagent carrying component 40 is provided in a disc-shaped structure, which has a plurality of positions for carrying a first reagent container 42 of the first reagent, and a plurality of positions for carrying a second reagent container 43 of the second reagent. The reagent carrying component 40 includes a first driving component for driving its rotation, the first driving component drives the reagent carrying component 40 to rotate and drives the first reagent container 42 to rotate, so as to rotate the first reagent container 42 to the first reagent suction position; the first driving component drives the reagent carrying component 40 to rotate and drives the second reagent container 43 to rotate, so as to rotate the second reagent container 43 to the second reagent suction position. In one example, the reagent carrying component 40 may include multiple circles of tracks that can rotate independently. For example, the reagent carrying component 40 may include two circles of tracks-an inner circle and an outer circle track, and a plurality of positions of the first reagent container 42 may be set on the outer circle track, and correspondingly, a plurality of positions of the second reagent container 43 may be set on the inner circle track, and the inner circle and outer circle tracks are driven to rotate independently by the first driving component.

[0070] Two types of reagent carrying components 40 are described above. For example, FIG. 4 (a) is an example of placing a reagent cup 41, and FIG. 4 (b) is an example of realizing the reagent carrying component 40 by multiple circles of independently rotatable tracks. Those skilled in the art can understand that the two methods can also be combined to realize the reagent carrying component 40 by multiple circles of independently rotatable tracks, and at least one circle of tracks or each circle of tracks has multiple positions for placing the reagent cup 41, for example Figure 5This is an example. The reagent carrying component 40 may include two circles of tracks - an inner circle and an outer circle. Multiple positions for placing reagent cups 41 can be set on the outer circle track. Correspondingly, multiple positions for placing reagent cups 41 can also be set on the inner circle track. The inner circle and outer circle tracks are driven to rotate independently by the first driving component.

[0071] The above is some description of the reagent carrying component 40. During the working cycle, the reagent carrying component 40 can rotate and dispatch the corresponding reagents required for the test items to the corresponding reagent suction positions of the reagent dispensing component 60 by rotating, for example, dispatching the first reagent to the first reagent suction position and dispatching the second reagent to the second reagent suction position.

[0072] The processing unit 50 is used to receive a reaction cup carrying a sample and process the sample in the reaction cup. The sample here refers to a reaction solution composed of a sample and a reagent. There can be one or more processing units 50.

[0073] Please refer to Figure 6 In some embodiments, the processing unit 50 has at least one reaction component 51 for incubating the sample, and the reaction component 51 is used to carry a reaction cup and incubate the sample in the reaction cup. In some embodiments, the reaction component 51 is rectangular and has multiple reaction cup placement positions. Generally, the reaction component 51 can heat the reaction liquid or sample in the reaction cup on each reaction cup placement position to incubate the sample, for example, heating the sample in the reaction cup and maintaining it at 37±0.5°C. The specific heating time and the heated temperature can be determined by the heating parameters corresponding to different test items. In some embodiments, the length direction of the reaction component 51 is set along the first direction, for example, along the Y direction in the figure.

[0074] In some embodiments, the processing unit 50 has at least one measuring component 52 for measuring the sample, and the measuring component 52 is used to carry the reaction cup and detect the sample in the reaction cup; in some embodiments, the measuring component 52 is rectangular and has multiple reaction cup placement positions. Generally, the measuring component 52 can be configured with a detection unit (not shown in the figure) for each reaction cup placement position, and each detection unit is used to detect the sample in the reaction cup at the corresponding reaction cup placement position. In some embodiments, the length direction of the measuring component 52 is set along a second direction different from the first direction, for example, it is set along the X direction in the figure.

[0075] In some embodiments, the reaction component 51 and the determination component 52 are disposed adjacently around the reagent carrying component 40. In some specific embodiments, the reaction component 51 and the determination component 52 are disposed along the first side 1a and the second side 1b, respectively, and surround the reagent carrying component 40 adjacently.

[0076] The rectangular reaction component 51 and the measuring component 52 are respectively arranged along the first side 1a and the second side 1b, and surround the reagent carrying component 40 in an adjacent manner, which can save space and reduce the size of the sample analysis device. It is also beneficial for the reagent carrying component 40 to interact with the reaction component 51 and the measuring component 52 through the reagent dispensing component 60.

[0077] In some embodiments, the sample component 20, such as the injection component 21, the reaction cup loading component 10, the reaction component 51 and the determination component 52 are arranged around the reagent carrying component 40. The present application is centered on the reagent carrying component 40, and the scheduling track of the entire detection process of the reaction cup is designed around the reagent carrying component 40, which is novel in design and saves space.

[0078] Each processing unit 50 can be configured with a corresponding reagent adding transfer position, for example, the reaction component 51 is configured with at least one incubation transfer position 51a for placing a reaction cup, and the number of incubation transfer positions 51a can be one or more; when the position of the incubation transfer position 51a for placing the reaction cup is set to 1, the incubation transfer position 51a can be set in a position-adjustable manner so that the reaction cup placed on the incubation transfer position 51a can correspond to each reagent needle in the first reagent dispensing component (the first reagent dispensing component corresponds to the reaction component and adds reagent to the reaction cup in the reaction component) to receive the reagent dispensed by each reagent needle. In some embodiments, the incubation transfer position 51a is arranged between the reagent carrying component 40 and the reaction component 51. The determination component 52 is configured with at least one determination transfer position 52a for placing a reaction cup, and the number of determination transfer positions 52a can be one or more; in some embodiments, the determination transfer position 52a is arranged between the reagent carrying component 40 and the determination component 52. When the position for placing the reaction cup at the measurement transfer position 52a is set to one, the measurement transfer position 52a can be set in a positionally adjustable manner so that the reaction cup placed on the measurement transfer position 52a can correspond to the positions of each reagent needle in the second reagent dispensing component (the second reagent dispensing component corresponds to the measurement component and adds reagent to the reaction cup in the measurement component) to receive the reagent dispensed by each reagent needle.

[0079] Figure 6 What is shown is that the number of incubation transfer positions 51a is one, and each incubation transfer position 51a has two reaction cup placement positions, such as the first position and the second position for placing the reaction cup; the number of measurement transfer positions 52a is one, and each measurement transfer position 52a has two reaction cup placement positions, such as the third position and the fourth position for placing the reaction cup.

[0080] The reagent dispensing component 60 is used to absorb the reagent from the reagent suction position and discharge it into the reaction cup of the reagent adding position. For example, the reagent dispensing component 60 can absorb the first reagent from the first reagent suction position mentioned in this article and discharge it into the reaction cup; the reagent dispensing component 60 can absorb the second reagent from the second reagent position mentioned in this article and discharge it into the reaction cup. In some embodiments, the reagent dispensing component 60 can be arranged in the housing 1.

[0081] The reagent dispensing component 60 can be implemented by a reagent needle. Therefore, in some embodiments, the reagent dispensing component 60 includes a reagent needle, which is used to absorb the reagent from the reagent carrying component 40 and discharge it into the reaction cup.

[0082] From the perspective of the number of reagent needles, in some embodiments, the reagent dispensing component 60 may have multiple reagent needles, and each reagent needle is arranged in a manner that can move independently of each other. Specifically, the reagent needles can be configured as follows: each processing unit 50 is configured with a group of reagent needles; the reagent needles are used to absorb reagents from the reagent carrying component 40 and discharge them into the reaction cup of the corresponding processing unit 50, and each group of reagent needles includes at least two reagent needles. For example, a group of reagent needles can be configured for the reaction component 51, and a group of reagent needles can be configured for the measurement component 52. In some specific embodiments, a first group of reagent needles can be configured for the reaction component 51, and the first group of reagent needles are arranged in a manner of linear motion between the reagent aspiration position and the incubation transfer position 51a, and the first group of reagent needles are used to aspirate reagents from the reagent aspiration position and discharge them into a reaction cup located at the incubation transfer position 51a, and the first group of reagent needles include at least one reagent needle; similarly, a second group of reagent needles can be configured for the measurement component 52, and the second group of reagent needles are arranged in a manner of linear motion between the reagent aspiration position and the measurement transfer position 52a, and the second group of reagent needles are used to aspirate reagents from the reagent aspiration position and discharge them into a reaction cup located at the measurement transfer position 52a, and the second group of reagent needles include at least one reagent needle.

[0083] From the perspective of the number of reagent dispensing components 60, in some embodiments, the number of reagent dispensing components 60 is equal to the number of processing units 50, and one reagent dispensing component 60 corresponds to one processing unit 50. Figures 1 to 3 These are all examples of this. Specifically, there may be two reagent dispensing components 60, the reaction component 51 corresponds to one of the reagent dispensing components 60, and the determination component 52 corresponds to the other reagent dispensing component 60. A reagent dispensing component 60 is configured for each processing unit 50, and the actions of the reagent adding process of the detection item are decomposed, that is, each reagent dispensing component 60 only needs to add the corresponding reagent to the reaction cup of the corresponding processing unit 50, which makes the adding of the corresponding reagent of the detection item completed by division of labor, which is conducive to improving efficiency.

[0084] Next, the specific structure of the reagent dispensing unit 60 will be described.

[0085] Please refer to Figure 7 Each reagent dispensing component 60 includes a plurality of reagent needles 61 and a guide assembly 62 for guiding the plurality of reagent needles 61 to make linear motion, and a second drive assembly 63 for driving the plurality of reagent needles 61 to make linear motion along the guide assembly 62. The guide assembly 62 is arranged along the direction determined by the reagent suction position and the reagent adding intermediate transfer position of the processing unit 50 corresponding to the reagent dispensing component 60, so that the reagent needle 61 absorbs the reagent from the reagent suction position and discharges it into the reaction cup at the reagent adding intermediate transfer position of the processing unit 50 corresponding to the reagent dispensing component 60. For example Figure 7 The reagent dispensing component 60 on the left side of the middle has a guide assembly 62 arranged along the direction determined by the reagent suction position and the incubation transfer position 51a of the reaction component 51, so that the reagent needle 61 of the reagent dispensing component 60 sucks the reagent from the reagent suction position and discharges it into the reaction cup located at the incubation transfer position 51a; Figure 7 The reagent dispensing component 60 on the right side of the middle has a guide component 62 arranged along the direction determined by the reagent aspiration position and the assay transfer position 52a of the assay component 52, so that the reagent needle 61 of the reagent dispensing component 60 draws the reagent from the reagent aspiration position and discharges it into the reaction cup located at the assay transfer position 52a. In some embodiments, the number of second drive components 53 of each reagent dispensing component 60 is equal to the number of reagent needles 61, and the independent driving force output ends of the multiple second drive components 53 act on the multiple reagent needles 61 accordingly, so as to independently drive the multiple reagent needles 61 to perform linear motion along the guide component 52 between the reagent aspiration position and the reagent addition transfer position. For example Figure 7 The example shown in FIG. 6 is an example in which each reagent dispensing component 60 includes two reagent needles 61 , and each reagent needle 61 is independently driven by its own second driving assembly 63 .

[0086] There are many ways to implement the guide component 52, and a few are listed below.

[0087] Figure 8It is a schematic diagram of the side of the reagent dispensing component 60. In some embodiments, the guide assembly 62 of each reagent dispensing component 60 includes: a crossbeam 62a, and a plurality of guide members 62b arranged in parallel and along the length direction of the crossbeam 62a; the crossbeam 62a is arranged along the direction determined by the reagent suction position and the reagent adding transfer position of the processing unit 50 corresponding to the reagent dispensing component 60; the number of guide members 62b is equal to the number of reagent needles 61 of the reagent dispensing component 60, and the plurality of reagent needles 61 are respectively slidably connected to the plurality of guide members 62b, so that the reagent needle 61 moves linearly along the guide members 62b between the reagent suction position and the reagent adding transfer position. In some embodiments, each reagent dispensing component 60 has two reagent needles 61; each reagent dispensing component 60 has two guide members 62b, and both guide members 62b are linear guides; the two linear guides are respectively arranged on both sides of the crossbeam 62a along the long axis direction of the crossbeam 62a—— Figure 8 What is shown is a schematic diagram of one side of the beam 62a, and the structure on the other side reveals a reagent needle 61; the two reagent needles 61 are respectively arranged on the linear guides on both sides of the beam 62a, and are slidably connected to the linear guides; the reagent needle 61 moves linearly between the reagent aspiration position and the reagent addition transfer position along the linear guides on which it is located.

[0088] This is an implementation method of realizing a reagent dispensing component by respectively setting a reagent needle on both sides of a beam. In other embodiments, a reagent dispensing component can also be realized by two parallel beams, each of which is only provided with a reagent needle, as described in detail below.

[0089] Please refer to Fig. 9 and Fig.10 In some embodiments, the guide assembly 62 of each reagent dispensing component 60 includes: a plurality of parallelly arranged beams 62a, and a plurality of guide members 62b respectively arranged on the plurality of the above-mentioned beams 62a and arranged along the length direction of the above-mentioned beams 62a; the plurality of the above-mentioned beams 62a are arranged along the direction determined by the reagent aspiration position and the reagent adding transfer position of the processing unit 50 corresponding to the reagent dispensing component 60; the number of guide members 62b is equal to the number of reagent needles 61 of the reagent dispensing component 60, and the plurality of reagent needles 61 are respectively slidably connected to the plurality of guide members 62b, so that the reagent needle 61 makes a linear motion along the guide member 62b between the reagent aspiration position and the reagent adding transfer position. In some embodiments, the multiple guide members 62b of each reagent dispensing component 60 are linear guides, and the multiple linear guides are respectively arranged along the long axis direction of the multiple beams 62a; the multiple reagent needles 61 are respectively arranged on the linear guides of the multiple beams 62a and are slidably connected to the linear guides; the reagent needles 61 perform linear motion between the reagent aspiration position and the reagent addition transfer position along the linear guides on which they are located.

[0090] In some embodiments, the crossbeam 52 a of the guide assembly 52 in each reagent dispensing component 60 is fixedly disposed above the reagent suction position and the reagent adding transfer position of the processing unit 50 corresponding to the reagent dispensing component 60 .

[0091] The reagent dispensing component 60 realizes the linear motion of multiple needles through the crossbeam structure. The movement trajectory of the reagent needle 61 does not take up too much space and minimizes the layout interference with other components, making the structure of the sample analysis device more compact, which is very beneficial to the miniaturized design of the sample analysis device.

[0092] In some embodiments, the linear motion trajectories of the reagent needles 61 of different reagent dispensing components 60 do not intersect with each other, so that the movements of the reagent needles 61 of different reagent dispensing components 60 will not be interfered with each other, which is beneficial to improving the test speed.

[0093] In some embodiments, there is at least one processing unit 50, and its reagent transfer position includes the same number of reaction cup placement positions as the reagent needles 61 of the reagent dispensing component 60 corresponding to the processing unit 50. Figure 6 In the example, the reagent adding transfer position of the reaction component 51 is the incubation transfer position 51a in the figure, and the incubation transfer position 51a can hold two reaction cups; the number of reagent needles 61 of the reagent dispensing component 60 corresponding to the reaction component 51 is two. Figure 6 In the figure, the reagent adding intermediate transfer position of the measuring part 52 is the measuring intermediate transfer position 52a in the figure, and the measuring intermediate transfer position 52a can place two reaction cups; the number of reagent needles 61 of the reagent dispensing part 60 corresponding to the measuring part 52 is two. In some embodiments, the number of the reagent suction positions is the same as the number of the reagent needles. For example Figure 6 There are two reagent dispensing parts 60, each of which has two reagent needles 61, so the number of reagent suction positions is four. The number of reagent needles is the same as the number of reagent adding positions, so that each reagent needle can clearly divide the work and add reagent to the reaction cup on its own reagent adding position, which is conducive to improving the test speed.

[0094] In some embodiments, the reagent needles 61 in the same reagent dispensing component 60 are used to absorb the same type of reagent. For example, the reagent needles 61 of the reagent dispensing component 60 corresponding to the reaction component 51 are all used to absorb the first reagent, and the reagent needles 61 of the reagent dispensing component 60 corresponding to the determination component 52 are all used to absorb the second reagent. Different reagent dispensing components 60 are used to absorb different reagents, which makes the division of labor of each reagent dispensing component 60 clear, which is conducive to improving the test speed.

[0095] In some embodiments, each reagent needle 61 of the reagent dispensing component 60 is provided with a heating component (not shown in the figure) for heating the reagent sucked by the reagent needle. Since each reagent dispensing component 60 includes multiple reagent needles 61, let's take two reagent needles as an example, and each reagent needle 61 is further provided with a heating component. Since there are two reagent needles 61, each reagent needle 61 has sufficient time, for example, doubled time, to heat the sucked reagent while maintaining the original speed, so that when the reagent reaches the corresponding processing unit 50, the temperature of the reagent is already close to the predetermined temperature, that is, the reagent has been fully preheated.

[0096] The above is some description of the reagent dispensing component 60. The following may take the case where the number of processing units 50 is two, specifically the reaction component 51 and the determination component 52 as an example to explain the matching relationship and corresponding structure between the reagent dispensing component 60 and the processing unit 50.

[0097] In some embodiments, the reagent dispensing component 60 corresponding to the reaction component 51 is a first reagent dispensing component, and the reagent dispensing component 60 corresponding to the measurement component 52 is a second reagent dispensing component, which is described in detail below.

[0098] In some embodiments, the first reagent dispensing component 60 includes a first crossbeam 6a and a first group of reagent needles, and the first group of reagent needles includes at least a plurality of first reagent needles 6b, for example, two; the plurality of first reagent needles 61 are arranged on the first crossbeam 62a, and move linearly along the long axis direction of the first crossbeam 62a to absorb the first reagent from the first reagent aspirating position and discharge it into the reaction cup located at the incubation transfer position 51a. In some embodiments, the first crossbeam 62a is arranged along the direction determined by the first reagent aspirating position and the incubation transfer position 51a, and the first crossbeam 62a is fixedly arranged at the upper position corresponding to the first reagent aspirating position and the incubation transfer position 51a.

[0099] In some embodiments, the first crossbeam 62a of the first reagent dispensing component 60 is set as one, and the above-mentioned multiple first reagent needles 61 are arranged in parallel on this first crossbeam 62a, and move linearly along the long axis direction of the first crossbeam 62a. Taking the first group of reagent needles with two first reagent needles 61 as an example, a linear guide is respectively arranged on both sides of the first crossbeam 62a along its long axis direction, and the two first reagent needles 61 are respectively arranged on the linear guides on both sides of the first crossbeam 62a, and the first reagent needle 61 moves linearly between the first reagent suction position and the incubation transfer position 51a along the linear guides. This is an implementation method of realizing the first reagent dispensing component by arranging a first reagent needle on both sides of a first crossbeam.

[0100] In some embodiments, the number of first beams 62a of the first reagent dispensing component 60 is equal to the number of the first reagent needles 61 of the first group of reagent needles, and each of the first beams 62a is provided with a first reagent needle 61, and the first beams 62a are arranged parallel to each other. In some specific embodiments, a plurality of first beams 62a are provided with a linear guide along their long axis, and the plurality of first reagent needles 61 are respectively arranged on the linear guides of the plurality of first beams 62a, so that the first reagent needles 61 can move linearly between the first reagent suction position and the incubation transfer position 51a. This is an implementation method of the first reagent dispensing component by providing a plurality of, for example, two parallel first beams, with only one first reagent needle on each first beam.

[0101] In some embodiments, the first reagent dispensing component 60 also includes a plurality of driving mechanisms that independently drive the plurality of first reagent needles to perform linear motion, such as second driving components, the number of the plurality of second driving components is equal to the number of the plurality of first reagent needles, and the independent driving force output ends of the plurality of second driving components act on the plurality of first reagent needles respectively to drive the plurality of first reagent needles to perform linear motion along the long axis direction of the first beam between the first reagent aspiration position and the incubation transfer position 51a.

[0102] Take the incubation transfer position 51a in the above text as an example, which includes the first position and the second position for placing the reaction cup. Then, in the example where the first reagent dispensing component 60 has two first reagent needles 61, one of the first reagent needles 61 moves linearly along the first cross beam 62a between the first reagent aspiration position and the first position, and the other first reagent needle 61 moves linearly along the first cross beam 62a between the first reagent aspiration position and the second position.

[0103] In some embodiments, the first reagent dispensing component 60 also includes a first Z-direction drive assembly 64 for driving the first reagent needles 61 in the first group of reagent needles to move in the vertical direction, and the number of the first Z-direction drive assemblies 64 is the same as the number of the first reagent needles 61 in the first group of reagent needles; the first Z-direction drive assembly 64 includes: a first Z-direction guide 64a for guiding the first reagent needle 61 to move in the vertical direction, and a first Z-direction drive 64b for driving the first reagent needle to move along the first Z-direction guide; the first reagent needle 61 forms a sliding connection with the first crossbeam 62a through the first Z-direction guide 64a and the first Z-direction drive 64b, so that the first reagent needle 61 can move in the vertical direction relative to the first crossbeam 62a under the drive of the first Z-direction drive 64b. It can be understood by those skilled in the art that when the reagent needle performs reciprocating linear motion, it needs to move in the vertical direction when reaching each position to complete operations such as absorbing and discharging reagents.

[0104] In some embodiments, the first reagent needle 61 may also be provided with a heating component (not shown in the figure) for heating the reagent sucked therein.

[0105] The above is some description about the first reagent dispensing part 60, and the second reagent dispensing part 60 will be described below.

[0106] The second reagent dispensing component 60 includes a second crossbeam 62a and a second group of reagent needles, and the second group of reagent needles includes at least a plurality of second reagent needles 61, for example, two; the plurality of second reagent needles 61 are arranged on the second crossbeam 62a, and move linearly along the long axis direction of the second crossbeam 62a to absorb the second reagent from the second reagent aspirating position and discharge it into the reaction cup located at the measurement transfer position 52a. In some embodiments, the second crossbeam 62a is arranged along the direction determined by the second reagent aspirating position and the measurement transfer position 52a, and the second crossbeam 62a is fixedly arranged at the upper position corresponding to the second reagent aspirating position and the measurement transfer position 52a.

[0107] In some embodiments, the second crossbeam 62a of the second reagent dispensing component 60 is provided as one, and the above-mentioned multiple second reagent needles 61 are arranged in parallel on this second crossbeam 62a, and move linearly along the long axis direction of the second crossbeam 62a. Taking the second group of reagent needles having two first reagent needles 61 as an example, a linear guide is respectively arranged on both sides of the second crossbeam 62a along its long axis direction, and the two second reagent needles 61 are respectively arranged on the linear guides on both sides of the second crossbeam 62a, and the second reagent needle 61 moves linearly between the second reagent suction position and the measurement transfer position 52a along the linear guides where it is located. This is an implementation method of realizing the second reagent dispensing component by arranging a second reagent needle on both sides of a second crossbeam.

[0108] In some embodiments, the number of second beams 62a of the second reagent dispensing component 60 is equal to the number of the second reagent needles 61 of the second group of reagent needles, and each of the second beams 62a is provided with a second reagent needle 61, and the second beams 62a are arranged parallel to each other. In some specific embodiments, the plurality of second beams 62a are provided with a linear guide along their long axis direction, and the plurality of second reagent needles 61 are respectively arranged on the linear guides of the plurality of second beams 62a, so that the second reagent needles 61 can move linearly between the second reagent suction position and the measurement transfer position 52a. This is an implementation method of the second reagent dispensing component by means of a plurality of, for example, two parallel second beams, each of which is provided with only one second reagent needle.

[0109] In some embodiments, the second reagent dispensing component 60 further includes a plurality of drive mechanisms that are different from the second drive assembly and independently drive the plurality of second reagent needles to perform linear motion, such as third drive assemblies, the number of the third drive assemblies is equal to the number of the plurality of second reagent needles, and the plurality of third drive assemblies have independent driving force output ends that act on the plurality of second reagent needles, respectively, to drive the plurality of second reagent needles to perform linear motion between the second reagent position and the measurement transfer position along the long axis direction of the second crossbeam. The second drive assembly and the third drive assembly may have the same structure.

[0110] Take the example that the transfer position 52a in the above determination includes the third position and the fourth position for placing the reaction cup. Then, in the example where the second reagent dispensing component 60 has two second reagent needles 61, one of the second reagent needles 61 moves linearly along the second cross beam 62a between the second reagent aspiration position and the third position, and the other second reagent needle 61 moves linearly along the second cross beam 62a between the second reagent aspiration position and the fourth position.

[0111] In some embodiments, the second reagent dispensing component 60 also includes a second Z-direction drive assembly 64 for driving the second reagent needles 61 in the second group of reagent needles to move in the vertical direction, and the number of the second Z-direction drive assemblies 64 is the same as the number of the second reagent needles 61 in the second group of reagent needles; the second Z-direction drive assemblies 64 include: a second Z-direction guide 64a for guiding the second reagent needle 61 to move in the vertical direction, and a second Z-direction drive 64b for driving the second reagent needle 61 to move along the second Z-direction guide 64a; the second reagent needle 61 forms a sliding connection with the second beam 62a through the second Z-direction guide 64a and the second Z-direction drive 64b, so that the second reagent needle 61 can move in the vertical direction relative to the second beam 62a under the drive of the second Z-direction drive 64b.

[0112] In some embodiments, the second reagent needle 61 may also be provided with a heating component (not shown in the figure) for heating the reagent absorbed by it.

[0113] In some embodiments, the linear motion trajectory of the multiple first reagent needles 61 of the first reagent dispensing component 60 between the first reagent aspiration position and the incubation transfer position 51a is the first motion trajectory; the linear motion trajectory of the multiple second reagent needles 61 of the second reagent dispensing component 60 between the second reagent aspiration position and the measurement transfer position 52a is the second motion trajectory; wherein the first motion trajectory does not intersect with the second motion trajectory.

[0114] The structures of the first reagent dispensing component 60 and the second reagent dispensing component 60 can be the same, but they are set in different directions. The first reagent dispensing component 60 is set in the direction of the reaction component 51 for cooperating with the reaction component 51, and the second reagent dispensing component 60 is set in the direction of the measuring component 52 for cooperating with the measuring component 52.

[0115] The above is some description of the reagent dispensing component 60. The reagent dispensing component 60 uses a crossbeam structure to make the reagent needle 61 continuously reciprocate between the reagent suction position of the reagent carrying component 40 and the reagent adding position of the corresponding processing unit to complete the suction and discharge of the corresponding reagent.

[0116] The movements of different reagent dispensing components 60 are independent and do not interfere with each other, thus playing a significant role in miniaturizing the space of the instrument and improving the test speed.

[0117] The scheduling component 70 is used to schedule the cuvettes. For example, the scheduling component 70 schedules the cuvettes that have been loaded with samples and are located in the sample loading position to the processing units 50 according to the detection process. For example, the scheduling component 70 schedules the cuvettes that have been loaded with reagents, such as the first reagent, at the incubation transfer position 51a to the reaction component 51, and schedules the cuvettes that have been loaded with reagents, such as the second reagent, at the measurement transfer position 52a to the measurement component 52. The specific structure of the scheduling component 70 is described below.

[0118] Please refer to Fig.11In some embodiments, the scheduling component 70 includes a first transport component 71, a second transport component 73, and a third transport component 75. In order to cooperate with the three transport components 71, 73, and 75, in some embodiments, the sample analysis device is also provided with a first cache transfer position 77 and a second cache transfer position 78. In some embodiments, the first cache transfer position 77 can adopt a fixed cache position design, with only one reaction cup placement position, that is, only one reaction cup can be placed, which is conducive to reducing the volume and size of the sample analysis device; similarly, the first cache transfer position 78 can adopt a fixed cache position design, with only one reaction cup placement position, that is, only one reaction cup can be placed, which is conducive to reducing the volume and size of the sample analysis device. Of course, in some embodiments, the first cache transfer position 77 and the second cache transfer position 78 can also be designed to have multiple reaction cup placement positions when adopting a fixed cache position design, so that there are more reaction cup placement positions in scheduling. Even in some embodiments, the first cache transfer position 77 can be designed as a movable or rotatable cache position. For example, the first cache transfer position 77 can include a cuvette placement position that can be driven to move or rotate. In this way, when the first transfer component 71 transfers the cuvette to the first cache transfer position 77, the first cache transfer position 77 can also be controlled to move or rotate to a predetermined position to receive the cuvette transferred by the first transfer component 71. In addition, when the second transfer component 73 needs to transfer the cuvette on the first cache transfer position 77, the first cache transfer position 77 can also be controlled to move or rotate to a predetermined position to enable the second transfer component 73 to grab the cuvette on the first cache transfer position 77 more quickly. The transfer position 78 may include a reaction cup placement position that can be driven to move or rotate, so that in the process of the second transfer component 73 transferring the reaction cup to the second cache transfer position 78, the second cache transfer position 78 can also be controlled to move or rotate to a predetermined position to receive the reaction cup transferred by the second transfer component 73. In addition, when the third transfer component 73 needs to transfer the reaction cup on the second cache transfer position 78, the second cache transfer position 78 can also be controlled to move or rotate to a predetermined position so that the third transfer component 75 can grab the reaction cup on the second cache transfer position 78 more quickly; through such a design, the entire transfer process of the reaction cup can be made faster and less time-consuming, thereby improving the efficiency and testing speed of the sample analysis device.

[0119] There are many specific implementation methods of the first transfer component 71, the second transfer component 73 and the third transfer component 75, such as a rail-type transfer component, which transfers the reaction cup by placing the reaction cup on the rail; another example is a turntable-type transfer component, which places the reaction cup on a turntable-type structure and transfers the reaction cup carried by the turntable to the corresponding position through the transfer of the turntable itself; for example, the first transfer component 71, the second transfer component 73 and the third transfer component 75 are implemented by driving a cup grabbing hand through a two-dimensional or three-dimensional driving mechanism, the reaction cup is grabbed by the cup grabbing hand, and then the cup grabbing hand is driven to move by a two-dimensional or three-dimensional driving mechanism, so as to realize the transfer of the reaction cup to the corresponding position. The following is an explanation of the method of implementing the transfer component by using a cup grabbing hand.

[0120] Referring to FIG. 12 (a), the first transport component 71, the second transport component 73, and the third transport component 75 all include a cup gripper 79 and a driving component for driving the cup gripper 79. In some embodiments, the cup gripper 79 is used to grip the reaction cup, for example Fig.13 It is a structural diagram of the cup gripper 79. The opening and closing of the cup gripper 79 can be realized by a driving mechanism and a spring. The opening of the cup gripper 79 can be driven to open by its driving mechanism. When the driving mechanism is not driven, the cup gripper 79 automatically closes and clamps the clamped object such as a reaction cup through its spring. In some examples, a circle of protrusions adapted to the gripper gripper can be set on the reaction cup.

[0121] The various transfer components and their functions are described below.

[0122] The first transport component 71 is used to transport the reaction cup after sample loading to the first buffer transfer position 77. In some embodiments, the first transport component 71 moves linearly along a first direction, such as the Y direction in the figure, to transport the reaction cup after sample loading to the first buffer transfer position 77. Since the first transport component 71 moves the reaction cup in a linear motion, the volume of the sample analysis device occupied during the reaction cup transportation process is relatively reduced, which is conducive to the miniaturization design of the sample analysis device.

[0123] Please refer to Fig.14In some embodiments, the sample analysis device may further be provided with a sample adding position 10a, a pre-dilution position 10b, a first cup throwing position 10c and a second cup throwing position 10d. In some embodiments, the first transport component 71 may move along a first direction, such as the Y direction in the figure, between the sample adding position 10a, the pre-dilution position 10b, the first cup throwing position 10c and the first cache transfer position 77. The sample adding position 10a may be a predetermined position where the reaction cup loading component 10 mentioned above loads an empty reaction cup. Generally, the sample dispensing component 30 sucks the sample from the sample suction position and discharges it into the reaction cup located at the sample adding position 10a to complete the sample addition. In some cases, the sample needs to be pre-diluted. Therefore, in this case, the first transport component 71 first transports the empty reaction cup on the sample adding position 10a to the pre-dilution position 10b, and the sample dispensing component 30 absorbs the sample from the sample suction position and discharges it into the reaction cup at the pre-dilution position 10b, and then dilutes the sample in the reaction cup at the pre-dilution position 10b; in this process, the reaction cup loading component 10 loads a new empty reaction cup onto the sample adding position 10a, and then the sample dispensing component 30 absorbs the pre-diluted sample from the reaction cup on the pre-dilution position 10b and discharges it into the sample adding position 10a, thereby completing the sample addition; the first transport component 71 then performs a cup throwing process on the reaction cup on the pre-dilution position 10b, for example, transports it to the first cup throwing position 10c for cup throwing.

[0124] As described above, in some embodiments, the first transfer component 71 only needs to move along the first direction, so the driving component of the first transfer component 71 can be a two-dimensional driving component, which is used to drive the cup grabbing hand 79 of the first transfer component 71 to move along the first direction and the vertical direction, wherein the first direction can be the Y direction in the figure, and the vertical direction is the direction perpendicular to the paper in the figure. Please refer to Figure 12 (b). In some embodiments, the first transfer component 71 includes a first direction guide 71a, a first direction driving component 71b, a vertical direction guide 71c and a vertical direction driving component 71d; a cup grabbing hand 79 of the first transfer component 71 is slidably provided on the vertical direction guide 71c, and the cup grabbing hand 79 can move in the vertical direction along the vertical direction guide 71c by driving the vertical direction guide 71c; a vertical direction guide 71c is slidably provided on the first direction guide 71a, and the vertical direction driving component 71b can move in the first direction along the first direction guide 71a, thereby driving the cup grabbing hand 79 of the first transfer component 71 to move in the first direction. Through such a structure, the cup grabbing hand 79 of the first transfer component 71 can move in two dimensions, namely, the first direction and the vertical direction. In some specific embodiments, the first direction guide 71a may include a first guide rail; the first direction driving component 71b may include a first stepper motor, a first driven wheel and a first synchronous belt, the first synchronous belt is sleeved between the first stepper motor and the first driven wheel, and the vertical direction guide 71c may be fixedly connected to the first synchronous belt; similarly, the vertical direction guide 71c may include a vertical guide rail; the vertical direction driving component 71d may include a lifting stepper motor and a vertical screw rod, and a mounting plate may be threadedly sleeved on the vertical screw rod for mounting the cup gripper 79 of the first transport component 71. In some embodiments, the first transport component 71 may also include a first bracket 71f for mounting the above-mentioned first direction guide 71a.

[0125] In some embodiments, the cup grabbing hand 79 of the first transport component 71 grabs the reaction cup on the sample loading position 10a, for example, along the second direction, for example, the X direction in the figure. In this way, the first transport component 71 will not affect the sample dispensing component 30 from discharging the sample into the reaction cup when grabbing the reaction cup. As a result, the sample dispensing component 30 can complete the loading of the sample into the reaction cup while the first transport component 71 grabs the reaction cup, thereby saving time and improving the measurement speed and efficiency.

[0126] The above is some description of the first transfer component 71.

[0127] The second transport component 73 is used to transport the cuvette in the first cache transfer position 77 to the reaction component 51, and to transport the cuvette in the reaction component 51 after the sample incubation is completed to the second cache transfer position 78. In some embodiments, the second transport component 73 transports the cuvette in the first cache transfer position 77 to the reaction component 51, and transports the cuvette in the reaction component 51 after the sample incubation is completed to the second cache transfer position 78 by linear motion along a first direction, such as the direction in the figure, and a second direction, such as the X direction in the figure. Since the second transport component 73 moves the cuvette in a linear motion, the volume of the sample analysis device occupied during the transportation of the cuvette is relatively reduced, which is conducive to the miniaturization design of the sample analysis device.

[0128] During the specific transportation process, the second transportation component 73 can first transport the reaction cup of the first cache transfer position 77 to the incubation transfer position 51a, the reagent dispensing component 60 absorbs the reagent and discharges it into the reaction cup located at the incubation transfer position 51a, and the second transportation component 73 then transports the reaction cup of the incubation transfer position 51a to the reaction component 51.

[0129] In some embodiments, the second transfer component 73 can move along a first direction (e.g., the Y direction in the figure), a second direction (e.g., the X direction in the figure), and a vertical direction (e.g., a direction perpendicular to the drawing), so the driving component of the second transfer component 73 can be a three-dimensional driving component, which is used to drive the cup grabbing hand 79 of the second transfer component 73 to move along the first direction, the second direction, and the vertical direction. Referring to FIG. 12 (c), in some embodiments, the second transfer component 73 includes a first direction guide 73a, a first direction driving component 73b, a second direction guide 73c, a second direction driving component 73d, a vertical direction guide 73e and a vertical direction driving component 73f; a cup grabbing hand 79 of the second transfer component 73 is slidably provided on the vertical direction guide 73e, and the cup grabbing hand 79 can move in the vertical direction along the vertical direction guide 73e through the driving of the vertical direction guide 73f; a vertical direction guide 73e is slidably provided on the second direction guide 73c, and the vertical direction driving component 73d can move in the second direction along the second direction guide 73c, thereby driving The cup grabbing hand 79 of the second transfer component 73 also moves in the second direction; a second direction guide 73c is slidably arranged on the first direction guide 73a, and driven by the first direction driving component 73b, the second direction guide 73c can move in the first direction along the first direction guide 73a, thereby driving the second direction guide 73c to move in the first direction, thereby driving the vertical direction guide 73e on the second direction guide 73c to move in the first direction, thereby driving the cup grabbing hand 79 of the second transfer component 73 on the vertical direction guide 73e to move in the first direction; through such a structure, the cup grabbing hand 79 of the second transfer component 73 can be moved in three directions, namely the first direction, the second direction and the vertical direction. In some specific embodiments, the first direction guide 73a may include a first guide rail; the first direction driving component 73b may include a first stepper motor, a first driven wheel and a first synchronous belt, the first synchronous belt is sleeved between the first stepper motor and the first driven wheel, and the second direction guide 73c may be fixedly connected to the first synchronous belt; similarly, the second direction guide 73c may include a second guide rail; the second direction driving component 73d may include a second stepper motor, a second driven wheel and a second synchronous belt, the second synchronous belt is sleeved between the second stepper motor and the second driven wheel, and the vertical direction guide 73e may be fixedly connected to the second synchronous belt; similarly, the vertical direction guide 73e may include a vertical guide rail; the vertical direction driving component 73f may include a lifting stepper motor and a vertical screw rod, and a mounting plate may be threadedly sleeved on the vertical screw rod for mounting the cup grabber 79 of the second transport component 73. In some embodiments, the second transport component 73 may also include a second bracket 73g for mounting the above-mentioned first direction guide 73a.

[0130] In some embodiments, the cup gripper 79 of the second transport component 73 grabs the reaction cup along the second direction, such as the X direction in the figure, so that the second transport component 71 will not affect the reagent dispensing component 60, such as the first reagent dispensing component, adding reagent to the reaction cup when grabbing the reaction cup, so that the reagent dispensing component 60 can complete the addition of reagent to the reaction cup while the second transport component 73 grabs the reaction cup, saving time and improving the measurement speed and efficiency. In some embodiments, the direction in which the second transport component 73 grabs the reaction cup is greater than 90 degrees from the direction of the linear motion of the first group of reagent needles. In this case, the action of the second transport component 73 grabbing the reaction cup and the action of the first group of reagent needles adding reagents are less likely to conflict, and the two can perform corresponding actions independently and in parallel in a very reasonable manner.

[0131] In some embodiments, the second transport component 73 also mixes the sample in the reaction cup during the process of transporting the reaction cup from the incubation transfer position 51a to the reaction component 51. For example, after the second transport component 73 transports the reaction cup with sample addition from the first buffer transfer position 77 and places it in the incubation transfer position 51a, the reagent dispensing component 60 then adds reagents, such as the first reagent, to the reaction cup on the incubation transfer position 51a, and the second transport component 73 picks up the reaction cup with reagent addition, mixes it, and then transports it to the reaction component 51; specifically, the second transport component 73 can drive the cup grabbing hand 79 to shake quickly through the driving component 71b to achieve mixing of the sample in the reaction cup grabbed by the cup grabbing hand 79. The second transport component 73 also has a mixing function, so that the sample analysis device does not need to be provided with an independent mixing mechanism, making the structure of the sample analysis device more compact and reducing costs; in addition, the second transport component 73 mixes when grabbing the reaction cup for transportation, which also saves time, and there is no need to specially dispatch the reaction cup to the corresponding mixing mechanism for mixing.

[0132] The above is some description of the second transport component 73. The second transport component 73 can and realizes the transport of reaction cups between the first cache transfer position 77, the incubation transfer position 51a, the reaction component 51 and the second cache transfer position 78 by linear motion along the first direction and the second direction.

[0133] The third transport component 75 is used to transport the cuvette in the second buffer transfer position 78 to the measuring component 52. In some embodiments, the third transport component 75 transports the cuvette in the second buffer transfer position 78 to the measuring component 52 by linear motion along a first direction, such as the direction in the figure, and a second direction, such as the X direction in the figure. Since the third transport component 75 moves the cuvette in a linear motion, the volume of the sample analysis device occupied during the cuvette transportation process is relatively reduced, which is conducive to the miniaturization design of the sample analysis device.

[0134] During the specific transportation process, the third transport component 75 may first transport the cuvette in the second buffer transfer position 78 to the measurement transfer position 52a, the reagent dispensing component 60 absorbs the reagent and discharges it into the cuvette located in the measurement transfer position 52a, and the third transport component 75 then transports the cuvette in the measurement transfer position 75a to the measurement component 52. In some embodiments, when the third transport component 75 transports the cuvette from the second buffer transfer position 78 to the measurement transfer position 52a, the third transport component 75 may not place the cuvette in the measurement transfer position 52a, but still grasp the cuvette. In this case, the reagent dispensing component 60 absorbs the reagent and discharges it into the cuvette, which reduces the time it takes for the cuvette to finally enter the measurement component 52 from the second buffer transfer position 78, thereby improving the test speed.

[0135] In some embodiments, the third transfer component 75 can move along a first direction (e.g., the Y direction in the figure), a second direction (e.g., the X direction in the figure), and a vertical direction (e.g., a direction perpendicular to the drawing), so the driving component of the third transfer component 75 can be a three-dimensional driving component, which is used to drive the cup grabbing hand 79 of the third transfer component 75 to move along the first direction, the second direction, and the vertical direction. Referring to FIG. 12 (d), in some embodiments, the third transfer component 75 includes a first direction guide 75a, a first direction driving component 75b, a second direction guide 75c, a second direction driving component 75d, a vertical direction guide 75e and a vertical direction driving component 75f; a cup grabbing hand 79 of the third transfer component 75 is slidably provided on the vertical direction guide 75e, and the cup grabbing hand 79 can move in the vertical direction along the vertical direction guide 75e through the driving of the vertical direction guide 75f; a vertical direction guide 75e is slidably provided on the second direction guide 75c, and the vertical direction driving component 75d can move in the second direction along the second direction guide 75c, thereby driving The cup grabbing hand 79 of the third transfer component 75 also moves in the second direction; a second direction guide 75c is slidably arranged on the first direction guide 75a, and driven by the first direction driving component 75b, the second direction guide 75c can move in the first direction along the first direction guide 75a, thereby driving the second direction guide 75c to move in the first direction, thereby driving the vertical direction guide 75e on the second direction guide 75c to move in the first direction, thereby driving the cup grabbing hand 79 of the third transfer component 75 on the vertical direction guide 75e to move in the first direction; through such a structure, the cup grabbing hand 79 of the third transfer component 75 can be moved in three directions, namely the first direction, the second direction and the vertical direction. In some specific embodiments, the first direction guide 75a may include a first guide rail; the first direction driving component 75b may include a first stepper motor, a first driven wheel and a first synchronous belt, the first synchronous belt is sleeved between the first stepper motor and the first driven wheel, and the second direction guide 75c may be fixedly connected to the first synchronous belt; similarly, the second direction guide 75c may include a second guide rail; the second direction driving component 75d may include a second stepper motor, a second driven wheel and a second synchronous belt, the second synchronous belt is sleeved between the second stepper motor and the second driven wheel, and the vertical direction guide 75e may be fixedly connected to the second synchronous belt; similarly, the vertical direction guide 75e may include a vertical guide rail; the vertical direction driving component 75f may include a lifting stepper motor and a vertical screw rod, and a mounting plate may be threadedly sleeved on the vertical screw rod for mounting the cup grabber 79 of the third transport component 75. In some embodiments, the third transport component 75 may also include a second bracket 75g for mounting the above-mentioned first direction guide 75a.

[0136] In some embodiments, the cup gripper 79 of the third transport component 75 grabs the reaction cup along a first direction, such as the Y direction in the figure, so that when the third transport component 75 grabs the reaction cup - even if the third transport component 75 grabs the reaction cup during the entire reagent adding process, it will not affect the reagent dispensing component 60, such as the second reagent dispensing component, adding reagent to the reaction cup, so that the reagent dispensing component 60 can complete the reagent addition to the reaction cup while the third transport component 75 grabs the reaction cup, saving time and improving the measurement speed and efficiency. In some embodiments, the direction in which the third transport component 75 grabs the reaction cup is greater than 90 degrees from the direction of the linear motion of the second group of reagent needles. In this case, the action of the third transport component 75 grabbing the reaction cup and the action of the second group of reagent needles adding reagents are less likely to conflict, and the two can perform corresponding actions independently and in parallel in a very reasonable manner.

[0137] In some embodiments, the third transport component 75 mixes the sample in the reaction cup during the process of transporting the reaction cup from the measurement transfer position 52a to the measurement component 52. For example, when the third transport component 75 transports the reaction cup from the second buffer transfer position 78 to the measurement transfer position 52a - in some embodiments, the third transport component 75 may not put down the reaction cup when transporting the reaction cup to the measurement transfer position 52a, but still grasps the reaction cup; the reagent dispensing component 60 then adds reagents such as the second reagent to the reaction cup at the measurement transfer position 52a, and the third transport component 75 mixes the sample in the grabbed reaction cup and then transports it to the measurement component 52; specifically, the third transport component 75 can drive the cup gripping hand 79 to shake quickly through the driving component 71b to achieve mixing of the sample in the reaction cup gripped by the cup gripping hand 79. The third transport component 75 also has a mixing function, so that the sample analysis device does not need to be equipped with an independent mixing mechanism, making the sample analysis device more compact and reducing costs. In addition, the third transport component 75 mixes the reaction cup on the original transport path, such as at the transfer position 52a during measurement, which saves time and eliminates the need to specifically dispatch the reaction cup to the corresponding mixing mechanism for mixing.

[0138] In some examples, after dispatching the reaction cup to the measuring component 52, the third transport component 75 can also grab the reaction cup that has been measured in the measuring component 52, and then transport it to the second cup throwing position 10d for cup throwing processing. In some embodiments, the second cup throwing position 10d can be set near the second cache transfer position 78, or between the measuring component 52 and the second cache transfer position 78. In this way, when the third transport component 75 transfers the reaction cup on the second cache transfer position 78 from the measuring component 52 to the second cache transfer position 78, it can also throw the reaction cup on the measuring component 52 that has been measured, thereby saving time and improving test efficiency.

[0139] The above is some description of the third transport component 75. The third transport component 75 can realize the transport of the reaction cup between the second buffer transfer position 78, the measurement transfer position 52a, the measurement component 52 and even the second cup throwing position 10d by linear movement along the first direction and the second direction.

[0140] The above is the description of the scheduling component 70 of some embodiments of the present invention. The present application uses three transfer components, namely the first transfer component 71, the second transfer component 73 and the third transfer component 75 to complete the rapid transfer of the reaction cup. The scheduling path of the reaction cup is simple and direct, which is conducive to speeding up the sample analysis device; and cooperates with two cache transfer positions, namely the first cache transfer position 77 and the second cache transfer position 78 to complete the transition between the three transfer components, and the structure is also simple and compact.

[0141] The above is the sample analysis device disclosed in some embodiments of the present invention. It can be understood that the sample analysis device disclosed in the present invention can also include some other structures, such as a cleaning component 80 and / or a processor 90, etc. Fig.15 and Fig.16 Let’s explain it in detail.

[0142] The cleaning component 80 is used to clean the reagent needle, for example, the first reagent needle and the second reagent needle. Specifically, the cleaning component 80 may include a plurality of cleaning pools 81, and the number of cleaning pools 81 may be the same as the number of reagent needles. For example, when the sample analysis device includes a first reagent dispensing component and a second reagent dispensing component, and each reagent dispensing component includes two reagent needles, the number of cleaning pools may be four. A cleaning pool may be provided on the trajectory of the linear motion of each reagent needle for cleaning the reagent needle. Please refer to Fig.16, cleaning component 80 is used to clean the reagent needle, specifically, it can be to clean the inner wall and outer wall of the reagent needle by cleaning liquid. Cleaning component 80 includes the cleaning pool in the figure, pipeline and the switch valve arranged on the pipeline, etc. The end of the reagent needle can be connected to a pipeline, and the pipeline is opened and closed by the switch valve SV01. When the switch valve SV01 is opened, the cleaning liquid can reach the end of the reagent needle through the pipeline, flow through the inner wall of the reagent needle, and flow out from the front end of the reagent needle, and complete the cleaning of the inner wall of the reagent needle by the cleaning liquid. The cleaning chamber is also connected to a pipeline, and the pipeline is opened and closed by the switch valve SV02. When the switch valve SV02 is opened, the cleaning liquid can reach the cleaning chamber through the pipeline, and spray from the inner wall of the cleaning chamber to the outer wall of the reagent needle, and complete the cleaning of the outer wall of the reagent needle by the cleaning liquid. The lower end of the cleaning chamber is connected to a waste liquid suction valve SV03 by a pipeline. When the waste liquid suction valve SV03 is opened, the waste liquid after cleaning flows out through the lower end of the cleaning chamber. During specific cleaning, the reagent needle comes to the top of the cleaning chamber, and then moves downward to extend part of the reagent needle (at least the part of the needle body that contacts the reagent liquid surface when sucking the reagent) into the cleaning chamber, so that the cleaning liquid sprayed in the cleaning chamber can clean the part of the needle body that contacts the liquid surface, completing the cleaning of the reagent needle. Each cleaning pool 81 can share the same set of liquid circuits to provide cleaning liquid for cleaning the reagent needle.

[0143] Some specific working processes of the sample analysis device are described below.

[0144] The sample analysis device in some embodiments may work as follows.

[0145] The reaction cup loading part 10 supplies and carries empty reaction cups. For example, the reaction cup loading part 10 can load the empty reaction cup to a predetermined position, which can be used as a sample adding position. The sample part 20, such as the sample injection part 21, dispatches the sample rack carrying the sample to the sample suction position. The sample dispensing part 30 draws the sample from the sample suction position and dispenses it into the reaction cup, for example, the sample dispensing part draws the sample from the sample suction position and then discharges it into the reaction cup located at the sample adding position to complete the sample addition.

[0146] The driving component of the reagent carrying component 60 drives the reagent carrying component 60 to rotate so that the reagent container carrying the first reagent is located at the first reagent suction position. At least one of the two reagent needles 61 on the first reagent dispensing component 60 absorbs the first reagent in the reagent container through the first reagent suction position, and makes a linear motion between the first reagent suction position and the reagent adding transfer position of the reaction component 51 to dispense the first reagent into the reaction cup at the reagent adding transfer position of the reaction component 51. The reagent adding transfer position of the reaction component 51 can be the incubation transfer position 51a mentioned in this article. In some embodiments, the two first reagent needles 61 of the first reagent dispensing component 60 independently make a linear motion between the first reagent suction position and the reagent adding transfer position of the reaction component 51. In this way, the two first reagent needles 61 of the first reagent dispensing component 60 can separately and independently - for example, alternately complete the operation of adding the first reagent to the reaction cup on the reagent adding transfer position of the reaction component 51, thereby improving the test speed and efficiency. In some specific embodiments, each first reagent needle 61 in the first reagent dispensing component 60 performs multiple preset actions in sequence to complete the operation of adding the first reagent, and among the multiple preset actions between the two first reagent needles 61, at least one corresponding preset action does not overlap in timing. In this way, the two reagent needles 61 of the first reagent dispensing component 60 can avoid occupying as few public resources as possible, so that the number of components providing corresponding public resources can be reduced, so that the sample analysis device can be more compact; and arranging the action timing of the two first reagent needles 61 in this way also avoids mutual influence between them as much as possible, which is very beneficial to speeding up the sample analysis device.

[0147] The scheduling component 70 schedules the reaction cup after the first reagent is dispensed to the reaction component 51 for incubation, and schedules the reaction cup after the incubation to the reagent transfer position of the measurement component 52. The reagent transfer position of the measurement component 52 can be the measurement transfer position 52a mentioned herein.

[0148] The reagent carrying part 40 rotates so that the reagent container carrying the second reagent is located at the second reagent suction position. At least one of the two reagent needles on the second reagent dispensing part 60 absorbs the second reagent in the reagent container through the second reagent suction position, and makes a linear motion between the second reagent suction position and the reagent adding transfer position of the measuring part to dispense the second reagent to the reaction cup at the reagent adding transfer position of the measuring part 52. In some embodiments, the two second reagent needles 61 of the second reagent dispensing part 60 move linearly between the second reagent suction position and the reagent adding transfer position of the measuring part 52 independently of each other. In this way, the two second reagent needles 61 of the second reagent dispensing part 60 can respectively and independently - for example, alternately complete the operation of adding the second reagent to the reaction cup at the reagent adding transfer position of the measuring part 52, thereby improving the test speed and efficiency. In some specific embodiments, each second reagent needle 61 in the second reagent dispensing part 60 performs a plurality of preset actions in sequence to complete the operation of adding the second reagent, and among the plurality of preset actions between the two second reagent needles 61, at least one corresponding preset action does not overlap in timing. In this way, the two reagent needles 61 of the second reagent dispensing component 60 can avoid occupying public resources as little as possible, so that the number of components providing corresponding public resources can be reduced, and the sample analysis device can be more compact; and arranging the action timing of the two second reagent needles in this way also avoids mutual influence between them as much as possible, which is very beneficial to speeding up the sample analysis device.

[0149] The scheduling component 70 schedules the reaction cup after the second reagent is dispensed to the measuring component 52 for item detection, and schedules the reaction cup after the detection to the waste recovery device, such as the second cup disposal position mentioned in this article.

[0150] Some embodiments of the present invention also disclose a sample analysis method. Fig.17 In some embodiments, the sample analysis method comprises the following steps:

[0151] Step 100, i.e., the cuvette loading step, controls the cuvette loading component to supply and carry the empty cuvette. For example, the cuvette loading component can load the empty cuvette to a predetermined position, and the predetermined position can be used as a sample loading position.

[0152] Step 110, ie, the sample feeding step, controls the sample component, such as the sample feeding component, to dispatch the sample rack carrying the sample to the sample suction position.

[0153] Step 120, i.e., the sample dispensing step, controls the sample dispensing component to absorb the sample from the sample aspirating position and dispense it into the reaction cup. For example, the sample dispensing component absorbs the sample from the sample aspirating position and then discharges it into the reaction cup located at the sample adding position to complete the sample adding.

[0154] Through the above steps 100 to 120, the sample addition is completed.

[0155] Step 130, i.e., the first reagent dispensing step, controls the driving component of the reagent carrying component to drive the reagent carrying component to rotate, so that the reagent container carrying the first reagent is located at the first reagent aspirating position; controls at least one of the two reagent needles on the first reagent dispensing component to absorb the first reagent in the reagent container through the first reagent aspirating position, and makes a linear motion between the first reagent aspirating position and the reagent adding intermediate transfer position of the reaction component, so as to dispense the first reagent into the reaction cup at the reagent adding intermediate transfer position of the reaction component. In step 130, the reagent adding intermediate transfer position of the reaction component can be the incubation intermediate transfer position mentioned herein.

[0156] In some embodiments, step 130 controls the two first reagent needles of the first reagent dispensing component to independently move linearly between the first reagent suction position and the reagent adding transfer position of the reaction component. In this way, the two first reagent needles of the first reagent dispensing component can independently and separately, for example, alternately complete the operation of adding the first reagent to the reaction cup on the reagent adding transfer position of the reaction component, thereby improving the test speed and efficiency. In some specific embodiments, step 130 controls each first reagent needle in the first reagent dispensing component to perform multiple preset actions in sequence to complete the operation of adding the first reagent, and among the multiple preset actions between the two first reagent needles, at least one corresponding preset action does not overlap in timing. In this way, the two reagent needles of the first reagent dispensing component can avoid occupying public resources as little as possible, so that the number of components providing corresponding public resources can be reduced, so that the sample analysis device can be more compact; and arranging the action timing of the two first reagent needles in this way also avoids mutual influence between them as much as possible, which is very beneficial to the speed-up of the sample analysis device. It should be noted that the multiple preset actions are different according to different test requirements. In one embodiment, the multiple preset actions include the following four: reagent aspiration action, heating action, reagent discharge action and cleaning action. Between two first reagent needles, at least one of the four actions does not overlap in timing.

[0157] Step 130 completes the process of adding the first reagent into the reaction cup containing the sample.

[0158] Step 140, i.e., the incubation step, controls the scheduling component to schedule the reaction cup after the first reagent is dispensed to the reaction component for incubation, and schedules the reaction cup after the incubation to the reagent transfer position of the measurement component. In step 140, the reagent transfer position of the measurement component can be the measurement transfer position mentioned herein.

[0159] Step 150, i.e., the second reagent dispensing step, controls the reagent carrying component to rotate so that the reagent container carrying the second reagent is located at the second reagent aspirating position; controls at least one of the two reagent needles on the second reagent dispensing component to absorb the second reagent in the reagent container through the second reagent aspirating position, and makes a linear motion between the second reagent aspirating position and the reagent adding transfer position of the measuring component, so as to dispense the second reagent into the reaction cup at the reagent adding transfer position of the measuring component.

[0160] In some embodiments, step 150 controls the two second reagent needles of the second reagent dispensing component to independently move linearly between the second reagent suction position and the reagent adding transfer position of the measuring component. In this way, the two second reagent needles of the second reagent dispensing component can independently and separately - for example, alternately complete the operation of adding the second reagent to the reaction cup on the reagent adding transfer position of the measuring component, thereby improving the test speed and efficiency. In some specific embodiments, step 150 controls each second reagent needle in the second reagent dispensing component to perform multiple preset actions in sequence to complete the operation of adding the second reagent, and among the multiple preset actions between the two second reagent needles, at least one corresponding preset action does not overlap in timing. In this way, the two reagent needles of the second reagent dispensing component can avoid occupying public resources as little as possible, so that the number of components providing corresponding public resources can be reduced, so that the sample analysis device can be more compact; and arranging the action timing of the two second reagent needles in this way also avoids mutual influence between them as much as possible, which is very beneficial for speeding up the sample analysis device. It should be noted that the multiple preset actions are different according to different test requirements. In one embodiment, the multiple preset actions include the following four: reagent aspiration action, heating action, reagent discharge action and cleaning action. Between two second reagent needles, at least one of the four actions does not overlap in timing.

[0161] Step 150 completes the process of adding the second reagent into the reaction cup carrying the incubated reagent.

[0162] Step 160, i.e., the measurement and recovery step, controls the scheduling component to schedule the reaction cup that has completed the second reagent injection to the measurement component for project detection, and schedules the reaction cup after the detection to the waste recovery device - the waste recovery device can have, for example, the second cup throwing position mentioned in this article.

[0163] The above is an overall working process of the sample analysis device.

[0164] The workflow arrangement of the reagent dispensing component 60 imposes important constraints on the speed of completing the test. Each reagent needle needs to complete the actions of aspirating, heating, discharging and cleaning. The reagent carrying component 40 is used to ensure the activity of the reagent, and the temperature is generally low, for example, below 16°C. After the reagent is taken out of the reagent carrying component 40, it needs to be heated to about 37°C in the reagent needle in a short time to ensure that the reaction process is sufficient. Under normal circumstances, the heating time of the reagent needle heating component for the reagent absorbed by the reagent needle takes 4 to 10 seconds. During the detection process of different test items, the reagent needle needs to absorb different types of reagents. For example, in the detection of the four routine coagulation items (PT / APTT / TT / FIB), different second reagents, that is, trigger reagents, need to be taken from the reagent carrying component 40 in turn and added to the reaction cup for reaction. Therefore, the same reagent needle needs to be cleaned normally or strongly when absorbing reagents for different items. In order to ensure the cleaning effect and avoid the carryover contamination between reagents affecting the accuracy of the test results, the cleaning time generally takes 2 to 8 seconds. The aspiration and discharging actions generally take 1.5 to 3 seconds (including the horizontal movement time). Therefore, for a sample analysis device, for example, with a single working cycle of 8 seconds, it is difficult to complete all the above-mentioned actions such as sample suction, heating, sample discharge and cleaning within one working cycle, and the overall detection speed is nearly reduced.

[0165] In some embodiments of the present invention, designs are made on how to perform the reagent adding operation in the sample analysis device, that is, how to arrange the action sequence of each reagent needle, which is described in detail below.

[0166] In some embodiments, the processor 90 is used to control each reagent needle in the same group to perform multiple preset actions in sequence, such as reagent suction action, reagent heating action in the reagent needle, reagent discharge action and reagent needle cleaning action to complete the reagent addition operation, and at least one corresponding preset action among the multiple preset actions between two reagent needles in the same group does not overlap in timing. For example, the first group of reagent needles in the first reagent dispensing component 60 includes two first reagent needles, and at least one corresponding preset action between the two first reagent needles does not overlap in timing. For another example, the second group of reagent needles in the second reagent dispensing component 60 includes two second reagent needles, and at least one corresponding preset action between the two second reagent needles does not overlap in timing. In some embodiments, a ping-pong mode can be set for the sample analysis device. When this mode is enabled, the processor 90 executes the ping-pong mode so that at least one corresponding action between two reagent needles in each group of reagent needles does not overlap in timing. For example, among the reagent aspirating action, reagent heating action, reagent discharge action, and reagent needle cleaning action of two reagent needles in the same group of reagent needles, at least one corresponding action does not overlap in timing; this at least one corresponding action includes a reagent aspirating action and / or a reagent needle cleaning action. In some other embodiments, for all reagent needles (including the first reagent needle and the second reagent needle) that perform reagent dispensing in the sample analysis device, the processor will control each reagent to perform the dispensing in turn. many Preset Actions To complete the reagent adding operation, and at least one corresponding preset action among the multiple preset actions between the two reagent needles does not overlap in timing. For example, the first reagent needle includes the first reagent needle a1 and the first reagent needle a2, and the second reagent needle includes the second reagent needle b1 and the second reagent needle b2. When the processor controls the first reagent needle a1, the first reagent needle a2, the second reagent needle b1 and the second reagent needle b2 to complete multiple preset actions respectively, at least one corresponding preset action does not overlap in timing. The processor arranges the timing of all reagent needles in the sample analysis device to avoid the actions between the reagent needles interfering with each other and occupying resources, thereby more effectively utilizing shared resources and improving the sample testing efficiency of the sample analysis device.

[0167] In some embodiments of the present invention, the above-mentioned multiple preset actions may include a first type of preset actions and a second type of preset actions. The first type of preset actions are actions in which each reagent needle needs to interact with the same component. Usually, the first type of preset actions may be some actions in which the reagent needle needs to occupy common resources, such as the reagent suction action - this requires occupying the common component of the reagent carrying component 40, such as the reagent needle cleaning action - this requires occupying the pipeline that provides cleaning liquid for each cleaning pool 81; therefore, the first type of preset actions at least include reagent suction actions and reagent needle cleaning actions. The second type of preset actions are actions in which each reagent does not need to interact with the same component. Usually, the second type of preset actions may be some actions in which the reagent needle does not need to occupy common resources, such as reagent heating actions - each reagent needle heats the sucked reagent through its own heating component; therefore, the second type of preset actions at least include reagent heating actions in the reagent needle. In some embodiments, the first type of preset actions corresponding to each pair of reagent needles in the same group do not overlap in timing, for example, the reagent suction actions between each pair of reagent needles in the same group do not overlap in timing, and the reagent needle cleaning actions do not overlap in timing, for example Fig.18 is an example.

[0168] In some embodiments, each corresponding preset action in the plurality of preset actions between two reagent needles in the same group does not overlap in timing. Fig.19 For example, the first group of reagent needles in the first reagent dispensing component 60 includes two first reagent needles, the reagent suction action between the two first reagent needles does not overlap in timing, the reagent heating action in the reagent needle does not overlap in timing, the reagent discharge action does not overlap in timing, and the reagent needle cleaning action and reagent suction action do not overlap in timing; for another example, the second group of reagent needles in the second reagent dispensing component 60 includes two second reagent needles, the reagent suction action between the two second reagent needles does not overlap in timing, the reagent heating action in the reagent needle does not overlap in timing, the reagent discharge action does not overlap in timing, and the reagent needle cleaning action and reagent suction action do not overlap in timing.

[0169] In some embodiments, the time interval between the output results of two adjacent and identical test items when the sample analysis device completes a fixed test volume is defined as a cycle, and the number of reagent needles set in each reagent dispensing component is equal to the number of cycles occupied by a reagent needle to complete the multiple preset actions. For example, the number of cycles occupied by a reagent needle to complete the above-mentioned multiple preset actions (such as reagent suction action, reagent heating action in the reagent needle, reagent discharge action and reagent needle cleaning action) is two, then two reagent needles are set for the reagent dispensing component, or the number of reagent needles in the same group is two. From another perspective, in some embodiments, the processor 90 controls each reagent needle of the reagent dispensing component to complete the multiple preset actions (such as reagent suction action, reagent heating action in the reagent needle, reagent discharge action and reagent needle cleaning action) within a preset time, and the preset time is equal to N times the cycle, and N is equal to the number of reagent needles of the reagent dispensing component. For example, the number of reagent needles in each reagent dispensing component 60 is two, then N is equal to two, and each reagent needle needs to complete the multiple preset actions (such as reagent suction action, reagent heating action in the reagent needle, reagent discharge action and reagent needle cleaning action) within two cycles. By setting the number of reagent needles of the reagent dispensing component and the cycle for completing the multiple preset actions in this way, the sample analysis device can eventually be made equivalent in terms of test speed to each reagent needle completing the multiple preset actions (such as reagent suction action, reagent heating action in the reagent needle, reagent discharge action and reagent needle cleaning action) within one cycle, ensuring that the speed at which the sample analysis device outputs the test results is constant. Here, a preset time is mentioned. In some embodiments, when the time taken by the reagent needle to perform multiple preset actions is less than the preset time, in order to further ensure that the speed at which the sample analysis device outputs the test results is constant, the reagent needle will wait so that the waiting time plus the time taken to complete the multiple preset actions is equal to the preset time. In order to be able to explain more clearly, the preset time includes action time and waiting time, wherein the action time is used to perform the above-mentioned preset actions (such as reagent suction action, reagent heating action in the reagent needle, reagent discharge action and reagent needle cleaning action), and the action time is less than or equal to the preset time. In some embodiments, the waiting time is divided into one or more time periods and is inserted between the plurality of preset actions and / or after the last preset action in terms of timing—for example, it is inserted between the reagent aspirating action, the reagent heating action in the reagent needle, the reagent discharging action and the reagent needle cleaning action in terms of timing and / or after the reagent needle cleaning action; for example Fig. 20is an example. In some embodiments, the waiting time is divided into one or more time periods, and at least one period is used as additional action time in the timing sequence to execute the preset action. In this way, the preset action can have extra time to continue to execute. Under the constraint of the preset time, the execution time of the preset action is extended, which can make the reagent needle have a more stable performance. For example, the execution time of the reagent suction action and the reagent discharge action is extended, which can make the reagent needle more stable to absorb and discharge the reagent, and it is not easy to cause abnormal situations such as empty suction or collision with the reaction cup. For another example, the execution time of the reagent heating action in the reagent needle is extended, which can make the reagent in the reagent be fully preheated; for another example, the execution time of the reagent needle cleaning action is extended, which can make the reagent needle be cleaned more fully, and it is not easy to cause cross contamination of the next test item, thereby improving the accuracy of the test results. Therefore, in some embodiments, the sample analysis device may include a full heating mode. When the full heating mode is enabled, the processor 90 executes the full heating mode so that the waiting time is divided into one or more time periods, and at least one of the time periods is used as an additional action time for performing the reagent heating action in the reagent needle. Fig.21 is an example.

[0170] It needs to be said that some Figures 18 to 21 In order to facilitate drawing, the heating action in the figure refers to the reagent heating action in the reagent needle in this article, and the cleaning action refers to the reagent needle cleaning action in this article; Figures 18 to 21 The two reagent needles drawn in the figure refer to two reagent needles in the same group, such as two first reagent needles in the first group of reagent needles, or two second reagent needles in the second group of reagent needles.

[0171] The present invention designs the action sequence of the reagent needle, introduces a reagent dispensing component with, for example, two reagent needles arranged in parallel, and the dual reagent needles that run independently in a straight line complete the entire workflow of reagent aspiration, preheating, reagent discharge and cleaning through ping-pong scheduling, and extends the cycle, providing double resources and ensuring speed improvement, thereby achieving the goal of not slowing down the testing of multiple detection items.

[0172] The following will further describe how the cuvette is dispatched by the dispatching component 70. In some embodiments, the present invention transports the cuvette by three transport components and two buffer transfer positions.

[0173] Some embodiments of the present invention also disclose a method of a sample analysis device, please refer to Fig. 22 , the method may include the following steps:

[0174] Step 200, control the first transport component to transport the cuvette with sample loading to the transfer position in the first buffer. In some embodiments, step 200 controls the first transport component to move linearly along the first direction to transport the cuvette with sample loading to the transfer position in the first buffer.

[0175] Step 210, control the second transport component to transport the cuvette transferred in the first buffer to the incubation position. The incubation position here can be the cuvette placement position in the reaction component 51. In some embodiments, step 210 controls the second transport component to transport the cuvette transferred in the first buffer to the incubation position by linear motion along the first direction and linear motion along the second direction.

[0176] Step 220, controlling the second transport component to transport the reaction cup in which the sample incubation in the incubation position has been completed to the transfer position in the second buffer.

[0177] In some embodiments, step 220 controls the second transport component to transport the cuvette in the incubation position where the sample is incubated to the second buffer transfer position by linear motion along the first direction and the second direction. In some specific embodiments, step 220 controls the second transport component to first transport the cuvette in the first buffer transfer position to the incubation transfer position for adding reagents, and then transport the cuvette in the incubation transfer position where the reagents are added to the incubation position to the incubation position.

[0178] In some specific embodiments, in step 220, the second transport component is controlled to mix the sample in the reaction cup during the process of transporting the reaction cup from the incubation transfer position to the incubation position. When the second transport component transports the reaction cup, the second transport component is also controlled to mix the sample in the reaction cup, which saves time and does not need to specially dispatch the reaction cup to the corresponding mixing mechanism for mixing.

[0179] Step 230, controlling the third transport component to transport the cuvette in the second buffer to the measurement position.

[0180] In some embodiments, step 230 controls the third transport component to transport the cuvette at the second buffer transfer position to the measurement position by linear motion along the first direction and the second direction. In some specific embodiments, step 230 controls the second transport component to first transport the cuvette at the second buffer transfer position to the measurement transfer position for adding reagents, and then transport the cuvette at the measurement transfer position after adding reagents to the measurement position.

[0181] In some specific embodiments, in step 230, the third transport component is controlled to mix the sample in the reaction cup during the process of transferring the reaction cup from the second buffer to the measurement position. When the third transport component transports the reaction cup, the third transport component is also controlled to mix the sample in the reaction cup, which saves time and does not need to specially dispatch the reaction cup to the corresponding mixing mechanism for mixing.

[0182] The rapid transportation of the reaction cup is achieved by the linear movement of the three transport components. With the two buffer transfer positions, the scheduling path of the reaction cup is simple and direct, which is conducive to speeding up the sample analysis device.

[0183] Finally, let's take the sample analysis device including the first reagent dispensing component 60 with two first reagent needles 61, the second reagent dispensing component 60 with two second reagent needles 61, the reaction component 51 and the determination component 52 as an example to illustrate the present invention in combination with a specific test item.

[0184] The reaction component 51 has a certain number of reaction cup placement positions, and can heat the sample in the reaction cup located at the reaction cup placement position to incubate the sample. Depending on the test items, some test items will require the addition of a first reagent, such as a mixed reagent. For example, when testing the APTT measurement item based on the coagulation method, the first reagent dispensing component 60 draws the first reagent, such as a mixed reagent, from the reagent carrying component 40, and discharges the drawn first reagent into the reaction cup located at the incubation transfer position 51a of the reaction component 51, thereby completing the mixing of the first reagent and the sample. After completing the addition of the mixed reagent, the second transport component 73 can mix the reaction liquid in the reaction cup, and then place the reaction cup into the reaction component 51, and the reaction component 51 incubates the reaction liquid or the sample in the reaction cup.

[0185] The reagent carrying part 40 is to ensure the activity of the reagent, so the working temperature is usually low, for example, usually below 16°C. In order to ensure that the coagulation reaction process is sufficient and obtain accurate test results, the first reagent needs to be heated to about 37°C before being added to the reaction cup and mixed with the sample. In order to improve the test speed of the sample analysis device, it is necessary to complete the heating of the first reagent in a short time, so the two first reagent needles 61 of the first reagent dispensing part 60 have heating parts for completing the reagent heating function. Under normal circumstances, the heating time of the reagent takes 4 to 10 seconds. For a high-speed sample analysis device, a single working cycle is, for example, 8 seconds. In this case, the heating time of the reagent will take up a long time, which has a great impact on improving the test speed of the sample analysis device. Therefore, in some embodiments of the present invention, the first reagent dispensing part 60 has two first reagent needles 61, and the two first reagent needles 61 respectively draw the first reagent, such as a mixed reagent, from the reagent carrying part 40, move to the incubation transfer position 51a through the linear guide fixed on the linear beam, and add the first reagent, such as a mixed reagent, to the reaction cup in turn. The two first reagent needles 61 are arranged in parallel and move independently. Due to the two independent first reagent needles 61, the working cycle time of the first reagent dispensing component 60 is doubled and can be extended to 16 seconds, which can fully ensure that the heating component of the reagent needle has sufficient heating time for the first reagent, so that the reagent temperature can be stably reached at 37°C.

[0186] After the sample in the reaction cup is heated and incubated in the reaction component 51 for a fixed time, the reaction cup is transferred to the measurement component 52 through the cooperation of the second transfer component 73 and the third transfer component 75. In some embodiments, the reaction cup can pass through the measurement transfer position 52a on the way for adding a second reagent such as a trigger reagent.

[0187] The third transport component 75 transports the reaction cup to the measurement transfer position 52a, and the second reagent dispensing component 60 draws the second reagent, such as the trigger reagent, from the reagent carrying component 40, moves to the top of the reaction cup grabbed by the third transport component 75, and adds the second reagent, such as the trigger reagent, to the reaction cup, so as to complete the mixing of the second reagent and the sample. After the addition of the trigger reagent is completed, the third transport component 75 can mix the reaction liquid in the reaction cup, and then place the reaction cup in the measurement component 52 to perform coagulation signal analysis and detection to obtain the test results.

[0188] Similar to the first reagent dispensing component 60, in order to ensure that the second reagent, such as the trigger reagent, has sufficient heating time, the second reagent dispensing component 60 also has two reagent needles, such as two second reagent needles; these two second reagent needles respectively draw the second reagent, such as the trigger reagent, from the reagent carrying component 40, move to the determination transfer position 52a through the linear guide fixed on the linear beam, and add the second reagent, such as the trigger reagent, to the reaction cup in turn. The two second reagent needles 61 are arranged in parallel and move independently. Due to the two independent second reagent needles 61, the working cycle time of the second reagent dispensing component 60 is doubled and can be extended to 16 seconds, which can fully ensure that the heating component of the reagent needle has sufficient heating time for the second reagent, so that the reagent temperature can be stably reached 37°C.

[0189] The cuvette in the measuring part 52 is irradiated with multi-wavelength light, and the transmitted light or scattered light is received by, for example, a light detector in the measuring part 52, and a detection signal corresponding to the amount of received light is output, and the detection signal can be sent to, for example, the processor 90 for data analysis, processing, and generation of corresponding display content. Sample analysis devices such as fully automatic coagulation analyzers can use different methods such as coagulation method, immunoturbidimetry, and chromogenic substrate method to perform sample analysis. According to different detection methods, the measuring part 52 irradiates light of different wavelengths to the cuvette, and the wavelength range can be, for example, between 405nm and 800nm.

[0190] The reaction cup that has completed the test can be transferred to the waste recovery device by the third transfer component 75 - the waste recovery device can have, for example, the second cup disposal position mentioned in this article. The third transfer component 75 discards the reaction cup into the second cup disposal position to complete the waste disposal of the reaction cup.

[0191] This document is described with reference to various exemplary embodiments. However, those skilled in the art will recognize that changes and modifications may be made to the exemplary embodiments without departing from the scope of this document. For example, various operating steps and components for performing the operating steps may be implemented in different ways (e.g., one or more steps may be deleted, modified, or combined into other steps) depending on the specific application or considering any number of cost functions associated with the operation of the system.

[0192] In the above embodiments, it can be implemented in whole or in part by software, hardware, firmware or any combination thereof. In addition, as understood by those skilled in the art, the principles of this article can be reflected in a computer program product on a computer-readable storage medium, which is pre-installed with a computer-readable program code. Any tangible, non-temporary computer-readable storage medium can be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD to ROM, DVD, Blu Ray disks, etc.), flash memory and / or the like. These computer program instructions can be loaded onto a general-purpose computer, a special-purpose computer, or other programmable data processing device to form a machine, so that these instructions executed on a computer or other programmable data processing device can generate a device that implements a specified function. These computer program instructions can also be stored in a computer-readable memory, which can instruct a computer or other programmable data processing device to operate in a specific manner, so that the instructions stored in the computer-readable memory can form a manufactured product, including an implementation device that implements a specified function. Computer program instructions can also be loaded onto a computer or other programmable data processing device, so that a series of operating steps are performed on the computer or other programmable device to generate a computer-implemented process, so that the instructions executed on the computer or other programmable device can provide steps for implementing a specified function.

Claims

1. A sample analysis device, characterized in that: include: chassis; A reaction cup loading component, used for supplying and carrying empty reaction cups; The sample introduction component is used to dispatch the sample rack carrying the sample to the sample suction position; The sample dispensing component is used to absorb the sample from the sample suction position and discharge it into the reaction cup located at the sample adding position; A reagent carrying component, the reagent carrying component is arranged in a disc-shaped structure, and has a plurality of positions for a first reagent container for carrying a first reagent, and a plurality of positions for a second reagent container for carrying a second reagent; the reagent carrying component includes a first driving component for driving the rotation thereof, the first driving component drives the reagent carrying component to rotate and drives the first reagent container to rotate, so as to rotate the first reagent container to a first reagent suction position; the first driving component drives the reagent carrying component to rotate and drives the second reagent container to rotate, so as to rotate the second reagent container to a second reagent suction position; A reaction component, used for carrying a reaction cup and incubating the sample in the reaction cup, wherein the reaction component is provided with at least one incubation transfer position for placing the reaction cup; A measuring component, used for carrying a reaction cup and detecting a sample in the reaction cup, wherein the measuring component is provided with at least one measuring transfer position for placing the reaction cup; The first reagent dispensing component includes: a first crossbeam and a first group of reagent needles, wherein the first crossbeam is provided as one, and the first group of reagent needles includes two first reagent needles; the two first reagent needles are provided on the first crossbeam and move linearly along the long axis direction of the first crossbeam to absorb the first reagent from the first reagent aspiration position and discharge it into the reaction cup located at the incubation transfer position; The second reagent dispensing component includes: a second crossbeam and a second group of reagent needles, wherein the second crossbeam is provided as one, and the second group of reagent needles includes two second reagent needles; the two second reagent needles are provided on the second crossbeam and move linearly along the long axis direction of the second crossbeam to absorb the second reagent from the second reagent aspiration position and discharge it into the reaction cup located at the measurement transfer position; The scheduling component is used to schedule the reaction cups; the scheduling component schedules the reaction cup with the first reagent added at the incubation transfer position to the reaction cup placement position of the reaction component, and schedules the reaction cup with the second reagent added at the measurement transfer position to the reaction cup placement position of the measurement component.

2. The sample analysis device according to claim 1, wherein: The first crossbeam is arranged along the direction determined by the first reagent aspiration position and the incubation transfer position, and the first crossbeam is fixedly arranged at an upper position corresponding to the first reagent aspiration position and the incubation transfer position; The second crossbeam is arranged along the direction determined by the second reagent aspiration position and the transfer position during measurement, and the second crossbeam is fixedly arranged at an upper position corresponding to the second reagent aspiration position and the transfer position during measurement.

3. The sample analysis device according to claim 2, wherein: A linear guide is provided on both sides of the first crossbeam along the long axis direction thereof, and two first reagent needles are respectively provided on the linear guides on both sides of the first crossbeam, and the first reagent needles move linearly between the first reagent aspiration position and the incubation transfer position along the linear guides on which they are located; The second crossbeam is provided with a linear guide rail on both sides along its long axis direction, and the two second reagent needles are respectively arranged on the linear guide rails on both sides of the second crossbeam. The second reagent needles move linearly between the second reagent aspiration position and the measurement transfer position along the linear guide rails.

4. The sample analysis device according to any one of claims 1 to 3, characterized in that: The first reagent dispensing component further includes two second drive components that independently drive the two first reagent needles to perform linear motion, and the two second drive components' respective independent driving force output ends act on the two first reagent needles respectively, so as to drive the two first reagent needles to perform linear motion between the first reagent aspiration position and the incubation transfer position along the long axis direction of the first crossbeam; The second reagent dispensing component also includes two third driving components that are different from the second driving components and independently drive the two second reagent needles to perform linear motion, and the two independent driving force output ends of the two third driving components act on the two second reagent needles respectively to drive the two second reagent needles to perform linear motion along the long axis direction of the second beam between the second reagent aspiration position and the measurement transfer position.

5. The sample analysis device according to any one of claims 1 to 3, characterized in that: The sample injection part, reaction cup loading part, reaction part and determination part are arranged around the reagent carrying part.

6. The sample analysis device according to any one of claims 1 to 3, characterized in that: The reaction component and the assay component are disposed adjacent to each other around the reagent carrying component.

7. The sample analysis device according to any one of claims 1 to 3, characterized in that: The transfer position during incubation is arranged between the reagent carrying component and the reaction component; the transfer position during measurement is arranged between the reagent carrying component and the measurement component.

8. The sample analysis device according to claim 5, wherein: The reaction component is rectangular in shape and has a plurality of reaction cup placement positions; the determination component is rectangular in shape and has a plurality of reaction cup placement positions.

9. The sample analysis device according to claim 8, wherein: The length direction of the reaction component is arranged along a first direction, and the length direction of the measurement component is arranged along a second direction different from the first direction.

10. The sample analysis device according to claim 9, wherein: The trajectory of the linear motion of the two first reagent needles of the first reagent dispensing component between the first reagent aspiration position and the incubation transfer position is the first motion trajectory; The trajectory of the linear motion of the two second reagent needles of the second reagent dispensing component between the second reagent aspirating position and the measurement transfer position is the second motion trajectory; The first motion trajectory does not intersect with the second motion trajectory.

11. The sample analysis device according to claim 10, wherein: The incubation transfer position includes a first position and a second position for placing a reaction cup, one of the first reagent needles moves linearly along the first crossbeam between the first reagent suction position and the first position, and the other first reagent needle moves linearly along the first crossbeam between the first reagent suction position and the second position; The transfer position in the assay includes a third position and a fourth position for placing a reaction cup, one of the second reagent needles moves linearly along the second beam between the second reagent aspiration position and the third position, and the other second reagent needle moves linearly along the second beam between the second reagent aspiration position and the fourth position.

12. The sample analysis device according to claim 11, wherein: The first reagent needle and / or the second reagent needle is provided with a heating component for heating the sucked reagent.

13. The sample analysis device according to claim 12, wherein: The first reagent dispensing component further includes a first Z-direction driving assembly for driving the first reagent needles in the first group of reagent needles to move in the vertical direction, and the number of the first Z-direction driving assemblies is the same as the number of the first reagent needles in the first group of reagent needles; The first Z-direction drive assembly includes: a first Z-direction guide for guiding the first reagent needle to move in the vertical direction, and a first Z-direction drive for driving the first reagent needle to move along the first Z-direction guide; the first reagent needle is slidably connected to the first crossbeam through the first Z-direction guide and the first Z-direction drive, so that the first reagent needle can move in the vertical direction relative to the first crossbeam under the drive of the first Z-direction drive; The second reagent dispensing component also includes a second Z-direction driving assembly for driving the second reagent needles in the second group of reagent needles to move in the vertical direction respectively, and the number of the second Z-direction driving assemblies is the same as the number of the second reagent needles in the second group of reagent needles; the second Z-direction driving assemblies include: a second Z-direction guide for guiding the second reagent needle to move in the vertical direction, and a second Z-direction driving member for driving the second reagent needle to move along the second Z-direction guide member; the second reagent needle forms a sliding connection with the second beam through the second Z-direction guide member and the second Z-direction driving member, so that the second reagent needle can move in the vertical direction relative to the second beam under the drive of the second Z-direction driving member.

14. A sample analysis device, characterized in that: include: A reaction cup loading component, used for supplying and carrying empty reaction cups; The sample introduction component is used to dispatch the sample rack carrying the sample to the sample suction position; The sample dispensing component is used to absorb the sample from the sample suction position and discharge it into the reaction cup located at the sample adding position; A reagent carrying component, used for carrying a reagent container and capable of rotating and rotating the reagent container to a reagent suction position; One or more processing units; the processing units are used to receive a cuvette carrying a sample and process the sample in the cuvette; each processing unit is configured with a corresponding reagent adding transfer position; One or more reagent dispensing components, the number of the reagent dispensing components is equal to the number of the processing units, and one reagent dispensing component corresponds to one processing unit; each reagent dispensing component comprises: two reagent needles, a guide assembly for guiding the two reagent needles to make linear motion, and a second driving assembly for driving the two reagent needles to make linear motion along the guide assembly, wherein the guide assembly of each reagent dispensing component comprises: a crossbeam, and two guide members arranged in parallel and along the length direction of the crossbeam, the crossbeam is arranged along the direction determined by the reagent aspiration position and the reagent adding transfer position of the processing unit corresponding to the reagent dispensing component, and the guide member is a linear guide rail; the guide assembly is arranged along the direction determined by the reagent aspiration position and the reagent adding transfer position of the processing unit corresponding to the reagent dispensing component, so that the reagent needle absorbs the reagent from the reagent aspiration position and discharges it into the reaction cup at the reagent adding transfer position of the processing unit corresponding to the reagent dispensing component; and The scheduling component is used to schedule the reaction cups that have completed the sample loading and are located in the sample loading position to each processing unit according to the detection process.

15. The sample analysis device according to claim 14, wherein: The crossbeam of the guide assembly in each reagent dispensing component is fixedly arranged above the reagent suction position and the reagent adding transfer position of the processing unit of the corresponding reagent dispensing component.

16. The sample analysis device according to claim 14, wherein: Two linear guides are respectively arranged on both sides of the beam along the long axis direction of the beam, and the two reagent needles are respectively arranged on the linear guides on both sides of the beam and are slidably connected with the linear guides; the reagent needles move linearly between the reagent aspiration position and the reagent addition transfer position along the linear guides on which they are located.

17. The sample analysis device according to any one of claims 14 to 16, characterized in that: The number of second drive components in each reagent dispensing part is equal to the number of reagent needles, and the independent driving force output ends of the multiple second drive components act on the multiple reagent needles accordingly, so as to independently drive the multiple reagent needles to move linearly along the guide component between the reagent suction position and the reagent addition transfer position.

18. The sample analysis device according to claim 17, wherein: The linear motion trajectories of reagent needles of different reagent dispensing components do not intersect with each other.

19. The sample analysis device according to any one of claims 14 to 16, characterized in that: The reagent needles in the same reagent dispensing unit are used to draw the same type of reagents.

20. The sample analysis device according to any one of claims 14 to 16, characterized in that: The reagent adding transfer position of at least one of the processing units includes reaction cup placement positions having the same number of reagent needles as that of the reagent dispensing component corresponding to the processing unit.

21. The sample analysis device according to any one of claims 14 to 16, characterized in that: Each reagent needle is provided with a heating component for heating the reagent sucked in the reagent needle.

22. The sample analysis device according to any one of claims 14 to 16, characterized in that: At least one of the processing units is a reaction component for incubating the sample.

23. The sample analysis device according to any one of claims 14 to 16, characterized in that: At least one of the processing units is a measuring component for measuring a sample.

24. The sample analysis device according to any one of claims 14 to 16, characterized in that: The number of the reagent aspiration positions is the same as the number of the reagent needles.

25. A sample analysis method, characterized in that: The following steps are involved: A reaction cup loading step, controlling the reaction cup loading component to supply and carry the empty reaction cup; A sample feeding step, controlling the sample feeding component to dispatch the sample rack carrying the sample to the sample suction position; The sample dispensing step controls the sample dispensing component to absorb the sample from the sample aspiration position and dispense it into the reaction cup; The first reagent dispensing step is to control the driving component to drive the reagent carrying component to rotate so that the reagent container carrying the first reagent is located at the first reagent aspirating position; control the two reagent needles provided on the first crossbeam on the first reagent dispensing component to absorb the first reagent in the reagent container through the first reagent aspirating position, and make a linear motion between the first reagent aspirating position and the reagent adding transfer position of the reaction component, so as to dispense the first reagent into the reaction cup at the reagent adding transfer position of the reaction component; Incubation step, controlling the scheduling component to schedule the reaction cup after the first reagent is dispensed to the reaction component for incubation, and scheduling the reaction cup after the incubation to the reagent adding transfer position of the measurement component; The second reagent dispensing step comprises controlling the reagent carrying component to rotate so that the reagent container carrying the second reagent is located at the second reagent aspirating position; controlling the two reagent needles on the second crossbeam on the second reagent dispensing component to aspirate the second reagent in the reagent container through the second reagent aspirating position, and to make a linear motion between the second reagent aspirating position and the reagent adding intermediate transfer position of the measuring component, so as to dispense the second reagent into the reaction cup at the reagent adding intermediate transfer position of the measuring component; In the determination and recovery step, the control scheduling component dispatches the reaction cup after the second reagent is dispensed to the determination component for project detection, and dispatches the reaction cup after the detection to the waste recovery device.

26. The method of claim 25, wherein: The first reagent dispensing step further comprises: The two first reagent needles of the first reagent dispensing component are controlled to independently move linearly between the first reagent aspirating position and the reagent adding transfer position of the reaction component.

27. The method according to claim 25 or 26, characterized in that The second reagent dispensing step further includes: The two second reagent needles of the second reagent dispensing component are controlled to independently move linearly between the second reagent aspirating position and the reagent adding transfer position of the measuring component.

28. The method of claim 27, wherein: The first reagent dispensing step further comprises: Each first reagent needle in the first reagent dispensing component is controlled to perform multiple preset actions in sequence to complete the first reagent adding operation, and among the multiple preset actions between two first reagent needles, at least one corresponding preset action does not overlap in time sequence.

29. The method of claim 28, wherein: The second reagent dispensing step further includes: Each second reagent needle in the second reagent dispensing component is controlled to perform multiple preset actions in sequence to complete the second reagent adding operation, and among the multiple preset actions between two second reagent needles, at least one corresponding preset action does not overlap in time sequence.

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