Liquid handling device

Abstract

The application discloses a liquid processing device, which comprises a sample processing unit and a pipetting unit. The sample processing unit is provided with a sample placement part, a reagent placement part and a reaction well, and the sample placement part, the reagent placement part and the reaction well are arranged along a first direction. The sample processing unit can move in the first direction. The pipetting unit is arranged above the sample processing unit. When the sample processing unit passes below the pipetting unit, the pipetting unit can transfer the liquid in the sample placement part and the reagent placement part to the reaction well. The liquid processing device of the application arranges the sample placement part, the reagent placement part and the reaction well in the same direction of the sample processing unit, and makes the sample processing unit move only in the direction, so that cross contamination caused by cross movement of the liquid in multiple directions can be avoided, the structure of the liquid processing device is simplified, the volume is reduced, and the production cost is effectively reduced.

Description

Technical Field

[0001] The present invention relates to the field of biomedical equipment, and in particular to a liquid processing device. Background Art

[0002] At present, most of the liquid handling devices on the market are fully automatic high-throughput plate processing platforms produced by foreign companies. Fully automatic high-throughput plate processing platforms are large in size and have complex systems. Such products are mostly suitable for laboratories with large demands. When the fully automatic high-throughput plate processing platform is in operation, the reaction plates of samples and reagents to be processed located at different workstations are transported and transferred to the corresponding reaction containers for reaction through the robotic arm handling gripper. In this process, multiple robotic arms are required to move in multiple directions to transfer the reaction plates to different workstations, which leads to a complex equipment structure, the need to reserve a large space, and high manufacturing costs. In addition, since the samples will move in multiple directions during the transfer, they are prone to cross-contamination. Summary of the Invention

[0003] The technical problem to be solved by the present invention is to provide a liquid processing device in order to overcome the defects of the liquid processing device in the prior art, such as complex structure, large space occupation, and easy cross contamination of samples during transfer.

[0004] The present invention solves the above technical problems through the following technical solutions:

[0005] A liquid processing device, comprising a sample processing unit and a pipetting unit, wherein the sample processing unit has a sample placement portion, a reagent placement portion, and a reaction well, wherein the sample placement portion, the reagent placement portion, and the reaction well are arranged along a first direction, and the sample processing unit is movable in the first direction;

[0006] The pipetting unit is disposed above the sample processing unit. When the sample processing unit passes below the pipetting unit, the pipetting unit can transfer liquids in the sample placement portion and the reagent placement portion to the reaction well.

[0007] In this solution, the above-mentioned structural form is adopted. By arranging the sample placement part, the reagent placement part and the reaction hole in the same direction of the sample processing unit, and making the sample processing unit move only in this direction, not only can the cross-contamination caused by the cross movement of the liquid in multiple directions be avoided, but also the structure of the liquid processing device is simplified, the volume is reduced, and the production cost is effectively reduced.

[0008] Preferably, the pipetting unit includes a lifting mechanism and a liquid suction mechanism, wherein the liquid suction mechanism is fixed on the lifting mechanism and can move in a vertical direction along with the lifting mechanism, and the liquid suction mechanism is used to transfer the position of the liquid on the sample processing unit.

[0009] In this solution, the above-mentioned structural form is adopted, and the transfer of various liquids on the sample processing unit is performed through the pipetting unit.

[0010] Preferably, the liquid suction mechanism includes a liquid suction component and a driving member, the liquid suction component includes a cylinder body with an inner cavity and a piston rod, the cylinder body is provided with a liquid suction head mounted on one end thereof opposite to the piston rod, and the liquid suction head is communicated with the inner cavity of the cylinder body;

[0011] The driving member is used to drive the piston rod to move within the cylinder body, so that the liquid suction component can suck in or discharge liquid.

[0012] In this solution, the above-mentioned structural form is adopted, and the piston rod is used to move in the inner cavity of the cylinder body to generate negative pressure or positive pressure in the cylinder body, so that the liquid suction component can suck in or discharge liquid.

[0013] Preferably, the liquid processing device includes an operating table having at least one first guide rail arranged along the first direction, and the sample processing unit is arranged on the first guide rail and can move on the first guide rail.

[0014] In this solution, the above-mentioned structural form is adopted, and the sample processing unit is arranged on the first guide rail, so that the sample processing unit can move stably along the first direction.

[0015] Preferably, the operating table further has a second guide rail arranged along a second direction, the second guide rail is cross-arranged above the first guide rail, and the pipetting unit is arranged on the second guide rail and can move along the second direction.

[0016] In this solution, the above-mentioned structural form is adopted, so that the pipetting unit can be movably arranged on the second guide rail, so that one pipetting unit can perform pipetting operations on multiple sample processing units.

[0017] Preferably, the operating table has a table top, a bracket is provided on the table top, the first guide rail is provided on the table top, and the second guide rail is provided on the bracket.

[0018] Preferably, the pipetting unit includes a first pipetting unit and a second pipetting unit, the first pipetting unit is fixed above the first guide rail, and the second pipetting unit is movable on the second guide rail.

[0019] In this solution, the above-mentioned structural form is adopted to perform pipetting operations on different liquids on the sample processing unit through two groups of pipetting units, thereby improving work efficiency and effectively avoiding contamination.

[0020] Preferably, the liquid processing device also includes a tip recovery trough, the operating table has a third guide rail arranged along the third direction, the third guide rail is cross-arranged below the second guide rail, and the tip recovery trough is arranged on the third guide rail and can move along the third direction.

[0021] In this solution, the above-mentioned structural form is adopted to facilitate the recovery of the liquid suction tip replaced on the pipetting unit.

[0022] Preferably, the liquid processing device also includes a tip placement assembly, the operating table has a fourth guide rail arranged along a fourth direction, the fourth guide rail is cross-arranged below the second guide rail, and the tip placement assembly is arranged on the fourth guide rail and can move along the fourth direction.

[0023] In this solution, the above-mentioned structural form is adopted to facilitate the automatic replacement of the liquid pipette tip by the pipetting unit.

[0024] Preferably, the sample processing unit includes a movable platform and a guide slide assembly, wherein the guide slide assembly is arranged on the lower bottom surface of the movable platform, and the guide slide assembly cooperates with the first guide rail.

[0025] Preferably, the sample placement portion is provided on a side surface of the movable platform, and the side surface is perpendicular to the first direction;

[0026] The reagent placement portion and the reaction well are provided on the upper end surface of the moving stage.

[0027] In this solution, the above-mentioned structural form is adopted, which not only facilitates the setting of the placement part, the transfer of liquid in the reagent placement part and the reaction hole by the pipetting unit, but also facilitates the external scanning unit to collect information about the sample on the sample placement part and information about the sample products on the upper end surface of the movable table.

[0028] Preferably, the liquid processing device also includes a control mechanism, which is used to control the sample processing unit to move in the first direction, and the control mechanism is also used to control the pipetting unit to transfer the liquid in the sample placement part and the reagent placement part to the reaction well. The control mechanism is also used to control the pipetting unit to transfer the sample product in the reaction well after the liquid processing in the reaction well is completed.

[0029] In this solution, the above-mentioned structural form is adopted to realize the automatic operation of the liquid processing device through the control mechanism, thereby improving work efficiency.

[0030] Preferably, the liquid processing device further comprises a code scanning unit, which is movable in a direction perpendicular to the first direction, and is used for identifying information of the liquid in the sample processing unit and transmitting the information to the control mechanism.

[0031] On the basis of conforming to the common sense in this field, the above-mentioned preferred conditions can be arbitrarily combined to obtain the preferred embodiments of the present invention.

[0032] The positive progressive effect of the present invention is that the liquid processing device of the present invention arranges the sample placement part, the reagent placement part and the reaction hole in the same direction of the sample processing unit, and makes the sample processing unit move only in this direction, which not only avoids cross-contamination caused by the cross movement of liquid in multiple directions, but also simplifies the structure of the liquid processing device, reduces the volume, and effectively reduces the production cost. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 Schematic diagram of the structure of a liquid treatment device in a preferred embodiment of the present invention.

[0034] Figure 2 This is a structural schematic diagram of the liquid treatment device from another perspective in a preferred embodiment of the present invention.

[0035] Figure 3 This is a front view of a liquid processing device in a preferred embodiment of the present invention.

[0036] Figure 4 1 is a top view of a liquid processing device in a preferred embodiment of the present invention.

[0037] Figure 5 for Figure 4 Schematic diagram of the AA section.

[0038] Figure 6 FIG. 1 is a structural diagram of a sample processing unit in a preferred embodiment of the present invention.

[0039] Figure 7 This is a front view of a sample processing unit in a preferred embodiment of the present invention.

[0040] Figure 8 FIG. 1 is a top view of a sample processing device in a preferred embodiment of the present invention.

[0041] Figure 9 for Figure 8 Schematic diagram of the cross section at AA in the middle.

[0042] Figure 10 for Figure 8 Schematic diagram of the cross section at BB in the middle.

[0043] Figure 11 Schematic diagram of the structure of the reaction unit in a preferred embodiment of the present invention.

[0044] Figure 12 Schematic diagram of the structure of the reaction unit in a preferred embodiment of the present invention.

[0045] Figure 13 FIG. 1 is a schematic diagram of the bottom structure of the sample processing unit in a preferred embodiment of the present invention.

[0046] Figure 14 Schematic diagram of the structure of the pipetting unit in a preferred embodiment of the present invention.

[0047] Figure 15 2 is a structural diagram of the pipetting unit from another perspective in a preferred embodiment of the present invention.

[0048] Figure 16 It is a front view of the pipetting unit in a preferred embodiment of the present invention.

[0049] Figure 17 2 is a cross-sectional view of a pipetting unit in a preferred embodiment of the present invention.

[0050] Figure 18 Schematic diagram of the structure of the liquid aspiration mechanism of the pipetting unit in a preferred embodiment of the present invention.

[0051] Figure 19 Schematic diagram of the structure of the lifting mechanism of the pipetting unit in a preferred embodiment of the present invention.

[0052] Description of reference numerals:

[0053] Operation table 1

[0054] First guide rail 101

[0055] First drive motor 1011

[0056] First driving belt 1012

[0057] Bracket 102

[0058] Second guide rail 1021

[0059] Second drive motor 1022

[0060] Second driving belt 1023

[0061] The third guide rail 103

[0062] Fifth guide rail 104

[0063] The third driving motor 1041

[0064] The third driving belt 1042

[0065] Sample processing unit 100

[0066] Mounting frame 110

[0067] Elastic clip 1101

[0068] Drive connection portion 1102

[0069] Guide slide assembly 1103

[0070] Reaction unit 120

[0071] Handheld unit 1201

[0072] Reaction unit 121

[0073] Reagent placement tank 1211

[0074] Reaction well 1212

[0075] Upper accommodating chamber 1212A

[0076] Lower accommodating chamber 1212B

[0077] Tip placement slot 1213

[0078] Amplification unit 122

[0079] Amplification placement hole 1221

[0080] Amplification tank assembly 1222

[0081] Waste liquid tank 1223

[0082] Sample placement section 130

[0083] Placement cavity 131

[0084] Gap 132

[0085] Magnetic component 140

[0086] Drive motor 1401

[0087] Gear 1402

[0088] Rack 1403

[0089] Permanent magnet 1404

[0090] Guide column 1405

[0091] Guide slide 1406

[0092] Temperature control unit 150

[0093] Liquid Tips 10

[0094] First pipetting unit 200

[0095] Separation piece 201

[0096] Guide rod 202

[0097] First guide seat 203

[0098] drive plate 204

[0099] spring 205

[0100] second guide seat 206

[0101] first mounting seat 210

[0102] suction head 211

[0103] cylinder body 212

[0104] piston rod 213

[0105] connecting pressure plate 214

[0106] first screw rod 215

[0107] first stepping motor 216

[0108] fixed seat 217

[0109] fixed plate 218

[0110] first sliding block 219

[0111] second mounting seat 220

[0112] second stepping motor 221

[0113] coupling 222

[0114] bearing seat 223

[0115] second sliding block 224

[0116] second screw rod 225

[0117] nut 226

[0118] nut fixed seat 227

[0119] first photoelectric device 231

[0120] first photoelectric partition plate 232

[0121] second photoelectric device 233

[0122] second photoelectric partition plate 234

[0123] second pipetting unit 300

[0124] suction head recycling groove 400

[0125] suction head placing assembly 500

[0126] control mechanism 600

[0127] The first code scanning unit 700 DETAILED DESCRIPTION

[0128] The application will be further described by way of examples without limiting the application to the following examples.

[0129] As Figure 1-5 shown, a liquid processing device of the present embodiment has an operation table 1, which includes a table top and a bracket 102 arranged above the table top, the table top of the operation table 1 has four first guide rails 101 arranged in a first direction, and the bracket 102 has second guide rails 1021 arranged in a second direction, which are arranged vertically above the first guide rails 101.

[0130] In other embodiments, the second guide rails 1021 and the first guide rails 101 can also be arranged at other angles.

[0131] Each of the first guide rails 101 is provided with a sample processing unit 100, and the sample processing unit 100 is movable along the first guide rails 101 in the first direction. The sample processing unit 100 has a sample placement portion 130, a reagent placement portion, and reaction wells 1212 arranged in the first direction, and the sample processing unit 100 is movable in the first direction.

[0132] The structure of the sample processing unit 100 of the present embodiment is shown in Figure 6-10 The sample processing unit 100 includes a moving table, which is composed of a mounting frame 110 and a reaction portion assembly 120. The upper surface of the mounting frame 110 has a mounting groove (not shown in the figure), and the reaction portion assembly 120 is placed in the mounting groove. The bottom of the reaction portion assembly 120 has a ring of protrusions extending to the periphery, and the reaction portion assembly 120 is clamped in the mounting groove on the mounting frame 110 by the protrusions.

[0133] Of course, in other embodiments, the mounting frame 110 and the reaction portion assembly 120 of the moving table can be an integrated structure.

[0134] As Figure 6-10As shown in FIG, in this embodiment, an elastic clamp 1101 is provided on one side of the mounting slot on the mounting frame 110. When the reaction unit assembly 120 is placed in the mounting slot, the elastic clamp 1101 abuts against the side of the reaction unit assembly 120 to prevent the reaction unit assembly 120 from loosening when the sample processing unit 100 moves. Preferably, the elastic clamp 1101 is provided on the side of the reaction unit assembly 120 in the direction of movement of the sample processing unit 100. Accordingly, a handle 1201 is provided on the side of the reaction unit assembly 120 opposite the elastic clamp 1101. The handle 1201 facilitates installation of the reaction unit assembly 120 in the mounting slot or removal of the reaction unit assembly 120 from the mounting slot. Specifically, during installation, the operator first holds the handheld part 1201 and places the other end of the reaction part assembly 120 into the installation slot, and presses the elastic clip 1101 with the reaction part assembly 120. After the reaction part assembly 120 is completely installed on the installation slot, the handheld part 1201 is released, and the elastic clip 1101 will press the reaction part assembly 120 under the action of its own elastic force; when removing, the operator first pinches the handheld part 1201 to push the reaction part assembly 120 toward one side of the elastic clip 1101, and then lifts one end of the handheld part 1201 to remove the reaction part assembly 120.

[0135] The movable platform includes a sample placement portion 130, a reagent placement portion, and reaction wells 1212. The sample placement portion 130, the reagent placement portion, and the reaction wells 1212 are disposed on the movable platform and arranged along a first direction. By disposing the sample placement portion 130, the reagent placement portion, and the reaction wells 1212 on the same movable platform and arranging them in the same direction, the sample processing unit 100 can transfer objects within the sample placement portion 130 and the reagent placement portion to the reaction wells 1212 by simply moving in a single direction. This not only simplifies the operation steps of the automated equipment but also prevents cross-contamination between samples.

[0136] like Figure 9-10 As shown, the upper accommodating chamber 1212A of reaction well 1212 is cylindrical, while the lower accommodating chamber 1212B of reaction well 1212 is tapered inward from top to bottom, with an arc-shaped transition between the upper and lower accommodating chambers 1212A and 1212B. This structure prevents splashing when adding liquid or magnetic beads to reaction well 1212.

[0137] like Figure 6-12As shown, in this embodiment, the reagent placement portion and the reaction hole 1212 are arranged on the reaction portion 121 of the reaction portion assembly 120, and the reagent placement portion has a plurality of reagent placement slots 1211, and the reagent placement slots 1211 are used to store reagents and magnetic beads for the reaction. The openings of the reagent placement slots 1211 and the reaction hole 1212 are both located on the upper surface of the reaction portion assembly 120, which is convenient for taking out the reagents and magnetic beads in the reagent placement slots 1211, and at the same time, it is convenient to add reagents, magnetic beads or samples to the reaction hole 1212, and to take out the liquid in the reaction hole 1212.

[0138] The sample placement section 130 is disposed on the mounting frame 110. The sample placement section 130 is positioned on a side surface of the mounting frame 110, perpendicular to the first direction. The sample placement section 130 includes a placement cavity 131, with the opening of the placement cavity 131 facing upward. A notch 132 is defined in the sidewall of the placement cavity 131, communicating with the placement cavity 131 and oriented in the first direction. The placement of the sample placement section 130 on the side surface of the mounting frame 110 facilitates the placement of sample tubes on the sample placement section 130 and facilitates the scanning device on the front side of the sample processing unit to scan the information on the sample tubes.

[0139] In other embodiments, the sample placement portion 130 may also be provided on the reaction portion assembly 120 , but the notch 132 on the side wall of the placement cavity 131 must face the first direction so that the information on the sample tube in the placement cavity 131 can be scanned by the barcode scanning device.

[0140] Of course, in other embodiments, the sample placement portion 130 may also be made of a transparent material, so that there is no need to open the notch 132 on the side wall of the placement cavity 131 .

[0141] In this embodiment, the sample processing unit 100 further includes a magnetic component 140, which can be raised and lowered below the reaction hole 1212; the magnetic component 140 is used to attract the magnetic beads in the reaction hole 1212 to the bottom of the reaction hole 1212 after the liquid reaction in the reaction hole 1212 is completed.

[0142] The magnetic attraction assembly 140 includes a permanent magnet 1404 and a lifting assembly. The permanent magnet 1404 is mounted on the lifting assembly, which is used to move the permanent magnet 1404 up and down so that the permanent magnet 1404 approaches or moves away from the reaction well 1212. During the reaction of the sample in the reaction well 1212, the lifting assembly moves the permanent magnet 1404 away from the reaction well 1212 to avoid affecting the magnetic beads in the reaction well 1212. After the reaction of the sample in the reaction well 1212 is completed, the lifting assembly moves the permanent magnet 1404 closer to the reaction well 1212 to attract the magnetic beads, facilitating the removal of the reaction solution in the reaction well 1212.

[0143] Specifically, if Figure 6-10As shown, the magnetic attraction assembly 140 includes a drive motor 1401, a gear 1402, a rack 1403, a permanent magnet 1404, a guide post 1405, and a guide slider 1406. The gear 1402 is fixed to the output shaft of the drive motor 1401, and the guide slider 1406 is slidably provided on the guide post 1405. A rack 1403 is fixed to one side of the guide slider 1406, and a permanent magnet 1404 is fixed to the upper end of the guide slider 1406. The rack 1403 is engaged with the gear 1402. The guide slider 1406 can move up and down on the guide post 1405 as the drive motor 1401 rotates forward and reverse, thereby driving the permanent magnet 1404 to move up and down, so that it approaches or moves away from the reaction hole 1212.

[0144] Of course, in other embodiments, the vertical movement of the permanent magnet 1404 can also be achieved through other mechanical mechanisms, for example, through a pneumatic or hydraulic telescopic rod, etc. Other structural types are not described here in detail.

[0145] In this embodiment, the sample processing unit 100 further includes a temperature control unit 150 for controlling the temperature of the liquid within the reaction well 1212. The temperature control unit 150 can be located within the reaction well 1212, outside the reaction well 1212, or integrated around the inner wall of the reaction well 1212. The temperature control unit 150 maintains the liquid within the reaction well 1212 at a suitable reaction temperature, thereby increasing reaction efficiency and facilitating an increase in the amount of desired reaction products.

[0146] like Figure 6-12 As shown, the amplification part 122 of the reaction part assembly 120 has a plurality of amplification placement holes 1221 arranged along the first direction, and an amplification tank assembly 1222 is placed on the amplification placement holes 1221. The amplification tank assembly 1222 includes a plurality of amplification tanks. The openings of the amplification tanks are provided on the upper surface of the reaction part assembly 120. The openings of the amplification tanks are sealed with a sealing film with an information barcode. The amplification tanks are used to place the reaction products obtained in the reaction holes 1212 so as to amplify the obtained reaction products. Figure 12 As shown, the reaction part assembly 120 of this embodiment is composed of a reaction part 121 and an amplification part 122 connected by a snap assembly, so that the amplification part 122 can be removed separately and sent into an amplification device for amplification processing.

[0147] The amplification section 122 is also arranged along the first direction of the sample processing unit 100, so that the required reaction products can be transferred to the amplification tank for amplification after the liquid reaction in the reaction hole 1212 is completed, so that the sample processing unit 100 always moves in only one direction, further simplifying the operation of the automated equipment.

[0148] like Figure 5 、 11As shown in Figure 12 , the sample processing unit 100 further includes a tip placement slot 1213. The opening of the tip placement slot 1213 is located on the upper surface of the reaction section 121 and is aligned with the reaction wells 1212 along a first direction. The provision of the tip placement slot 1213 facilitates tip replacement during movement of the sample processing unit 100, allowing different liquid tips to be replaced by simply moving the sample processing unit 100 in one direction.

[0149] like Figure 8-9 and Figure 11-12 As shown, the sample processing unit 100 further includes a waste liquid tank 1223, which is disposed on the amplification section 122. The opening of the waste liquid tank 1223 is located on the upper surface of the amplification section 122 and is aligned with the reaction wells 1212 along a first direction. The waste liquid tank 1223 is used to store reaction waste liquid generated in the reaction wells 1212. This allows the sample processing unit 100 to transfer waste liquid from the reaction wells to the waste liquid tank by moving in only one direction, simplifying the structure and operation of the automated equipment.

[0150] Of course, in other embodiments, the waste liquid tank 1223 may also be disposed on the reaction portion 121 of the reaction portion assembly 120 , or on the mounting frame 110 .

[0151] like Figure 13 As shown, the sample processing unit 100 includes a guide slide assembly 1103, which is arranged on both sides of the lower bottom surface of the mounting frame 110, and is used to slide in conjunction with the first guide rail 101. Figure 5 As shown, the first driving motor 1011 controls the movement of the first driving belt 1012. The first driving belt 1012 has a snap-fit ​​portion 1102 at the middle position of the lower bottom surface of the mounting bracket 110 for fixing. Therefore, the sample processing unit 100 moves on the first guide rail 101 under the drive of the first driving motor 1011.

[0152] Of course, in other embodiments, the number of the first guide rail 101 may be one or other numbers, and the number of the corresponding sample processing units 100 may also be one or other numbers.

[0153] like Figure 1-4 As shown, the pipetting unit is mounted on the second guide rail 1021 and is movable in the second direction. This allows one pipetting unit to perform pipetting operations on four sample processing units 100 mounted on the first guide rail 101. As the sample processing units 100 pass beneath the pipetting unit, the pipetting unit transfers samples from the sample tubes on the sample placement portion 130 and reagents and magnetic beads from the reagent placement slots 1211 to the reaction wells 1212.

[0154] The liquid processing device arranges the sample placement portion 130, the reagent placement portion, and the reaction well 1212 in the same direction of the sample processing unit 100, and allows the sample processing unit 100 to move only in that direction. This not only avoids cross-contamination caused by cross-movement of liquids in multiple directions, but also simplifies the structure of the liquid processing device, reduces its volume, and effectively reduces production costs.

[0155] In this embodiment, there are two groups of pipetting units, namely a first pipetting unit 200 and a second pipetting unit 300. The first pipetting unit 200 is fixed above the first guide rail 101, and the second pipetting unit 300 is movable on the second guide rail 1021. There are four first pipetting units 200, each corresponding to the four sample processing units 100, and there is only one second pipetting unit 300. The second pipetting unit 300 transfers liquid from the four sample processing units 100 by moving on the second guide rail 1021.

[0156] The second pipetting unit 300 is driven by the driving mechanism to move on the second guide rail 1021. Figure 1 As shown, the driving mechanism includes a second driving motor 1022 and a second driving belt 1023. The second driving belt 1023 has a snap-fit ​​position fixed to the snap-fit ​​portion on the second pipetting unit 300. Therefore, the second pipetting unit 300 moves on the second guide rail 1021 under the drive of the second driving motor 1022.

[0157] In other embodiments, there may be multiple second pipetting units 300; or, there may be only one first pipetting unit 200, which transfers liquids from different sample processing units 100 by moving on the guide rail. Of course, in other embodiments, the number of first pipetting units 200 is not limited to one or the number corresponding to the number of sample processing units, and may be other numbers.

[0158] The two sets of pipetting units are used to perform pipetting operations on different liquids on the sample processing unit, thereby improving work efficiency and effectively avoiding contamination.

[0159] The first pipetting unit 200 and the second pipetting unit 300 may use an existing pipette gun or a pipetting assembly with the following structure. In this embodiment, the first pipetting unit 200 uses a pipetting assembly with the following structure, and the second pipetting unit 300 uses an existing pipette gun.

[0160] like Figure 14-19The structure of the pipetting assembly of this embodiment is shown. The pipetting assembly includes a liquid suction mechanism, which has a liquid suction head 211. The liquid suction head 211 is detachably mounted with a liquid suction head 10, wherein the liquid suction head 211 has a plug connector, and the liquid suction head 10 has a corresponding plug hole. The liquid suction head 10 and the liquid suction head 211 can be plugged and fixed under the action of an external force, and can be separated under the action of an external force. The pipetting assembly also includes a suction head detachment mechanism, which is used to detach the liquid suction head 10 from the suction head 211. The pipetting assembly can automatically detach the liquid suction head 10 from the suction head 211 through the suction head detachment mechanism, avoiding the use of manual means to detach the liquid suction head 10, and can fully realize the automated operation of the pipetting assembly, thereby increasing the working efficiency of the pipetting assembly.

[0161] See Figure 14-17 In this embodiment, the liquid suction mechanism and the suction head separation mechanism are both mounted on the mounting surface of the first mounting seat 210. Figure 17 As shown, the liquid aspiration mechanism includes a liquid aspiration assembly, which includes a cylinder 212 having an inner cavity and a piston rod 213. A liquid aspiration head 211 is mounted on one end of the cylinder 212 opposite the piston rod 213. The liquid aspiration head 211 is in communication with the inner cavity of the cylinder 212. The movement of the piston rod 213 creates a negative or positive pressure within the cylinder 212, thereby aspirating or discharging liquid through the liquid aspiration head 10 on the liquid aspiration head 211.

[0162] In this embodiment, the movement of the piston rod 213 is controlled by a first stepper motor 216 and a first screw 215. The first screw 215 is connected to the piston rod 213. The first stepper motor 216 is used to drive the first screw 215 to move the piston rod 213, thereby causing the liquid pipette tip 10 on the pipette head 211 to aspirate or discharge liquid. Controlling the movement of the piston rod 213 by the first stepper motor 216 not only provides precise control but also facilitates automated operation.

[0163] Of course, in other embodiments, the piston rod 213 may also be controlled to move by other driving mechanisms, such as a pneumatic or hydraulic telescopic mechanism or other types of motors.

[0164] To improve work efficiency, multiple groups of liquids can be sucked simultaneously. The liquid suction mechanism is provided with multiple liquid suction components. In this embodiment, there are four liquid suction components. The piston rods 213 of the four liquid suction components are connected to the first screw 215 via the same connecting plate 214. The up and down movement of the first screw 215 will simultaneously drive the four piston rods 213 to move, allowing the four liquid suction components to suck or discharge liquid simultaneously. By fixing the piston rods 213 of multiple liquid suction components to the same connecting plate 214, multiple liquid suction components can be controlled by only one stepper motor, saving costs. It can also synchronize the operation of multiple liquid suction components, avoiding errors in the same group of liquid suction components during pipetting, and increasing the accuracy of the test results.

[0165] In other embodiments, the number of liquid-absorbing components can be set according to needs, and can be one or more.

[0166] like Figure 14-16 As shown, in this embodiment, to ensure the stability of the liquid suction mechanism during operation, the two ends of the cylinder 212 of the liquid suction assembly are fixed to the first mounting base 210 via a fixing base 217 and a fixing plate 218. Of course, in other embodiments, the liquid suction assembly can also be fixed by only one fixing device.

[0167] In this embodiment, if Figure 14-16 As shown, the tip detachment mechanism includes a detachment member 201, which is disposed on a side of the liquid suction head 211 away from the liquid suction head 10. The detachment member 201 is movable relative to the liquid suction head 211, so that the liquid suction head 10 is subjected to a force from the detachment member 201, causing the liquid suction head 10 to move in a direction away from the liquid suction head 211. The relative movement of the detachment member 201 and the liquid suction head 211 causes the detachment member 201 to exert a force on the liquid suction head 10 on the liquid suction head 211, thereby detaching the liquid suction head 10 from the liquid suction head 211.

[0168] Among them, the separation piece 201 is a strip plate, on which are opened four through holes corresponding to the liquid suction head 211 of the liquid suction assembly. The inner diameter of the through hole is larger than the outer diameter of the liquid suction head 211 and smaller than the outer diameter of the end of the connection end between the liquid suction head 10 and the liquid suction head 211.

[0169] In this embodiment, the tip detachment mechanism further includes a first driving member, which is used to drive the detachment member 201 to switch between a first position and a second position, wherein the liquid suction head 211 is in a fixed position relative to the first mounting base 210; in the first position, the detachment member 201 does not hinder the connection between the liquid suction head 10 and the liquid suction head 211; in the second position, the detachment member 201 can detach the liquid suction head 10 from the liquid suction head 211.

[0170] By controlling the movement of the detachment member 201, the detachment member 201 is switched between the first position and the second position, and when the detachment member 201 is in the first position, the detachment member 201 does not hinder the connection between the liquid suction head 10 and the liquid suction head 211, that is, at this time the liquid suction head 10 can be installed on the liquid suction head 211 without hindrance; when in the second position, the detachment member 201 can detach the liquid suction head 10 from the liquid suction head 211, that is, at this time the detachment member 201 can detach the liquid suction head 10 on the liquid suction head 211, and the external liquid suction head 10 cannot be installed on the liquid suction head 211.

[0171] Of course, in other embodiments, the separation member 201 may be in a fixed position relative to the first mounting seat 210, and the liquid suction head 211 may switch between the first position and the second position relative to the separation member 201; in the first position, the separation member 201 does not hinder the connection between the liquid suction head 10 and the liquid suction head 211; in the second position, the separation member 201 can separate the liquid suction head 10 from the liquid suction head 211.

[0172] The tip detachment mechanism also includes a guide seat and a guide rod 202. The guide seat is positioned between the first drive member and the detachment member 201. The guide rod 202 extends through the guide seat and is movable within the guide seat. One end of the guide rod 202 is connected to the detachment member 201, and the other end is connected to the first drive member. In addition to providing power to the detachment member 201, the guide rod 202 also serves as a guide, allowing the detachment member 201 to accurately detach the liquid tip 10.

[0173] In this embodiment, the guide seat of the guide rod 202 on the same side includes a first guide seat 203 and a second guide seat 206, which are respectively located at the ends of the fixed plate 218 and the fixed seat 217. The first guide seat 203 and the fixed plate 218 are independently arranged, and the second guide seat 206 and the fixed seat 217 are integrally formed.

[0174] In other embodiments, there are two guide seats on the same side guide rod 202, which are located at the upper and lower ends of the guide rod 202 respectively, and are independently arranged or integrally formed with the fixing seat 217 and the fixing plate 218; or, there is only one guide seat on the same side guide rod 202, which is located in the middle of the guide rod 202.

[0175] Specifically, see Figure 14-16 In this embodiment, the first driving member is a driving plate 204 disposed below the connecting pressure plate 214. The driving plate 204 is a strip-shaped plate structure, with its ends fixedly connected to the ends of the detaching member 201 via guide rods 202. Driven downward by the first stepper motor 216, the connecting pressure plate 214 presses against the driving plate 204. The downward movement of the driving plate 204 causes the guide rods 202 to drive the detaching member 201 toward the liquid suction head 10. Because the inner diameter of the through-hole in the detaching member 201 is smaller than the outer diameter of the connecting end of the liquid suction head 10, the liquid suction head 10 can be detached from the liquid suction head 211. In this embodiment, the connecting pressure plate 214 drives the driving plate 204 to control the movement of the detaching member 201, eliminating the need for an additional driving mechanism to drive the detaching member 201. This simplifies the structure and reduces costs.

[0176] Of course, in other embodiments, the disengagement member 201 may also be controlled to move by other types of driving mechanisms, for example, it may be directly driven by a pneumatic or hydraulic telescopic mechanism, or it may be driven by a motor, which will not be described in detail here.

[0177] When the connecting plate 214 is in its initial position, it does not drive the piston rod 213 or the liquid aspiration and discharge of the liquid pipetting head 211, and the disengagement member 201 is in its first position, where it does not obstruct the connection between the liquid aspiration head 10 and the liquid pipetting head 211. Since the first stepper motor 216 directly or indirectly controls not only the aspiration and discharge of the liquid pipetting head 211 but also the movement of the disengagement member 201, the first stepper motor 216, via the first screw 215, controls the connecting plate 214 to move in the following four directions relative to its initial position.

[0178] After the liquid suction head 10 is detached, the first stepper motor 216 drives the connecting pressure plate 214 to move toward the direction of returning to the initial position. At this time, the piston rod 213 can discharge the absorbed liquid. This is the second movement stroke; when the liquid suction head 211 needs to be detached, the first stepper motor 216 drives the connecting pressure plate 214 to move from the initial position to the side close to the liquid suction head 211. The connecting pressure plate 214 will press the driving plate 204, and then the driving plate 204 can drive the separation member 201 to move, so that the separation member 201 separates the liquid suction head 10. This is the third movement stroke; after the liquid suction head 10 is detached, the first stepper motor 216 will drive the connecting pressure plate 214 to return to the initial position. This is the fourth movement stroke.

[0179] In this embodiment, the drive plate 204 and the connecting plate 214 are separately provided. After the connecting plate 214 transitions from the third travel range to the fourth travel range, the connecting plate 214 stops applying force to the drive member, allowing the disengagement member 201 to return to the first position where it does not obstruct the connection between the liquid tip 10 and the pipetting head 211, facilitating the installation of a new liquid tip 10 for the next pipetting operation.

[0180] In this embodiment, a reset unit is provided to enable the detaching member 201 to return from the second position to the first position when no external force is applied to the detaching member 201. Figure 14-16 In this embodiment, the reset unit is a spring 205, which is sleeved on the guide rod 202. One end of the spring 205 is fixed to the first guide seat 203, and the other end of the spring 205 is connected to the drive plate 204. The retraction force of the spring 205 resets the drive plate 204, thereby returning the disengaging member 201 to the first position. This has the advantages of simple structure and low cost.

[0181] In other embodiments, one end of the spring 205 may be fixed to the second guide seat 206 and the other end of the spring 205 may be connected to the separation member 201 .

[0182] Alternatively, in other embodiments, when the disengaging piece 201 is driven by a pneumatic or hydraulic telescopic mechanism, or an electric motor, the reset unit can also be provided together with the same.

[0183] In other embodiments, the driving plate 204 can be fixedly connected with the connecting pressure plate 214, in which case, the connecting pressure plate 214 can drive the disengaging piece 201 to reset, and a separate reset unit is not required. However, it should be noted that the maximum stroke range of the connecting pressure plate 214 when driving the piston rod 213 to suck liquid cannot be greater than the movable stroke of the disengaging piece 201 on the liquid suction head 211, otherwise the disengaging piece 201 will touch the fixed seat 217 and cause damage to the pipetting assembly, or other unpredictable conditions will occur.

[0184] Alternatively, in other embodiments, when the disengaging piece 201 is in a fixed position relative to the first mounting seat 210, and the liquid suction head 211 is switched between the first position and the second position relative to the disengaging piece 201, the reset unit is used to return the liquid suction head 211 from the second position to the first position, and the setting mode of the reset unit will not be described here.

[0185] As shown in Figure 14-17 and Figure 19 , in the present embodiment, the pipetting assembly further comprises a lifting mechanism for controlling the up-and-down movement of the liquid suction mechanism. One side of the first mounting seat 210 relative to the mounting surface is fixed on the lifting mechanism, so that the first mounting seat 210 moves in the vertical direction with the lifting mechanism. By controlling the lifting of the first mounting seat 210 through the lifting mechanism, not only can the liquid suction head 10 be inserted and installed by the downward movement of the liquid suction mechanism, but also the liquid suction head 10 can be controlled to move up and down, which is convenient for sucking and discharging liquid.

[0186] Specifically, please refer to Figure 18-19 , wherein the lifting mechanism comprises a second stepper motor 221, a second screw rod 225, a nut 226, and a second mounting seat 220. The second mounting seat 220 is installed with the second stepper motor 221 and a bearing seat 223. The nut 226 is fixed on one side of the first mounting seat 210 relative to the mounting surface through a nut fixing seat 227. The lower end of the second screw rod 225 penetrates the nut 226, and the upper end of the second screw rod 225 penetrates the bearing in the bearing seat 223 and is fixedly connected with the output shaft of the second stepper motor 221 through a shaft coupling 222. The second stepper motor 221 drives the second screw rod 225 to rotate to make the nut 226 drive the first mounting seat 210 to move along the axial direction of the second screw rod 225.

[0187] A first slider 219 and a second slider 224 are respectively provided on the first mounting seat 210 and the second mounting seat 220 . The first slider 219 and the second slider 224 can slide in coordination to ensure the stability of the first mounting seat 210 when it moves up and down driven by the lifting mechanism.

[0188] In this embodiment, in order to avoid program setting errors causing the piston rod 213 to move upward excessively and damage the pipetting components, a limit mechanism is also provided to limit the maximum movement stroke of the piston rod 213 during aspiration. Figure 14 and Figure 16 As shown, a first photoelectric device 231 is provided on the first mounting seat 210, and a first photoelectric partition 232 is provided on the movable pressure plate. When the first photoelectric partition 232 cuts off the signal of the first photoelectric device 231, the first stepper motor 216 stops working.

[0189] In other embodiments, in order to avoid the connection pressure plate 214 moving downward to press against the separation member 201, causing the lower end of the piston rod 213 to move excessively and damage the pipetting assembly, a photoelectric component can also be set to control the maximum movement stroke of the connection pressure plate 214 to drive the separation member 201 to move.

[0190] In this embodiment, in order to prevent the lifting mechanism from controlling the first mounting seat 210 to move upward excessively due to program setting errors, a limit mechanism is provided to limit the maximum movement stroke of the first mounting seat 210 during the lifting process. Figure 15 As shown, a second photoelectric device 233 is provided on the second mounting seat 220, and a second photoelectric partition 234 is provided on the first mounting seat 210. When the second photoelectric partition 234 cuts off the signal of the second photoelectric device 233, the second stepper motor 221 stops working and the second screw 225 no longer drives the first mounting seat 210 to rise.

[0191] The liquid handling device of this embodiment further includes a tip recovery tank 400. The operating table 1 has a third guide rail 103 arranged along the third direction. The third guide rail 103 is vertically arranged below the second guide rail 1021. The tip recovery tank 400 is arranged on the third guide rail 103 and can move along the third direction. The tip recovery tank 400 is provided to facilitate the recovery of the liquid tips 10 replaced on the pipetting unit. Figure 1-4 As shown, in this embodiment, the third guide rail 103 and the first guide rail 101 are arranged parallel to each other on the table surface of the operating table 1, that is, the third direction is parallel to the first direction.

[0192] In other embodiments, the third guide rail 103 and the second guide rail 1021 may also intersect at other angles. The third guide rail 103 may also be non-parallel to the first guide rail 101, but the third guide rail 103 does not cross or contact the first guide rail 101 to prevent the liquid processing unit from colliding with the tip recovery trough during operation.

[0193] In other embodiments, the third guide rail 103 may not be provided on the table top of the operating table 1 , but may be provided at a certain height lower than or higher than the table top of the operating table 1 , which will not be described in detail here.

[0194] like Figure 1-4 As shown, the liquid handling device further includes a tip placement assembly 500. The operating table 1 has a fourth guide rail disposed along a fourth direction, intersecting below the second guide rail 1021. The tip placement assembly 500 is disposed on the fourth guide rail and is movable along the fourth direction. The tip placement assembly 500 facilitates automatic replacement of liquid tips 10 by the second pipetting unit 300. In this embodiment, the fourth guide rail shares a common rail with the third guide rail 103.

[0195] In other embodiments, the fourth guide rail can also be set separately, and its setting direction and position can be the same as or different from the third guide rail 103. The setting of the fourth guide rail cannot interfere with the movement of objects on the first guide rail 101, the second guide rail 1021 and the third guide rail 103.

[0196] The driving method for the movement of the tip recovery trough 400 on the third guide rail 103 and the tip placement assembly 500 on the fourth guide rail is the same as the driving method for the movement of the sample processing unit 100 on the first guide rail 101. Of course, in other embodiments, other existing driving methods can also be used, which will not be detailed here.

[0197] like Figure 1-2 and Figure 4 As shown, the liquid handling device further includes a control mechanism 600, which is used to control the sample processing unit 100 to move in a first direction. The control mechanism 600 is also used to control the pipetting unit to transfer liquid in the sample placement portion 130 and the reagent placement portion to the reaction well 1212. The control mechanism 600 is also used to control the pipetting unit to transfer the sample product in the reaction well 1212 after the liquid in the reaction well 1212 is processed. The control mechanism 600 realizes the automated operation of the liquid handling device, thereby improving work efficiency.

[0198] The liquid processing device of this embodiment further includes a first code scanning unit 700 and a second code scanning unit (not shown in the figure). Figure 1-4 As shown, a fifth guide rail 104 is provided on the front side of the operating table 1, and the fifth guide rail 104 is perpendicular to the first guide rail 101. The first code scanning unit 700 can be moved on the fifth guide rail 104 in a direction perpendicular to the first direction under the drive of the driving mechanism. The first code scanning unit 700 is used to identify the information of the sample in the sample tube on the front side of the sample processing unit 100 and transmit it to the control mechanism.

[0199] The first code scanning unit 700 is driven by the driving mechanism to move on the fifth guide rail 104. Figure 1 As shown, the driving mechanism includes a third driving motor 1041 and a third driving belt 1042. The third driving belt 1042 has a snap-fit ​​position fixed to the snap-fit ​​portion on the first code scanning unit 700. Therefore, the first code scanning unit 700 moves on the fifth guide rail 104 under the drive of the third driving motor 1041.

[0200] The second barcode scanning unit of this embodiment is provided on the second pipetting unit 300 and moves along with the second pipetting unit 300. When the sample processing unit 100 passes under the second barcode scanning unit, the second barcode scanning unit can identify the information of the sealing film of the opening of the amplification tank and transmit it to the control mechanism.

[0201] In other embodiments, the second code scanning unit may be fixed on the bracket 102 above the first guide rail 101 .

[0202] When the liquid processing device is working, the first code scanning unit 700 first moves to the front of the sample processing unit 100 to scan and collect sample information; the control mechanism controls the amplification tank of the sample processing unit 100 to move to the working position of the first pipetting unit 200, and punctures the sealing film on the amplification tank through the tip of the liquid suction head 10; then the sample placement part 130 of the sample processing unit 100 is moved to the working position of the second pipetting unit 300, and the second pipetting unit 300 transfers the sample in the sample tube of the sample placement part 130 to the reaction hole 1212 through the liquid suction head 10; then the reagent placement part of the sample processing unit 100 is moved to the working position of the first pipetting unit 200, and the first pipetting unit 20 The reagents, magnetic beads, etc. in the reagent placement tank 1211 are transferred to the reaction well 1212 via a liquid pipette tip. After the reaction is completed, the control mechanism controls the drive motor 1401 of the magnetic attraction assembly 140 to move the permanent magnet 1404 to the bottom of the reaction well 1212. The permanent magnet 1402 attracts and gathers the magnetic beads in the reaction well 1212. The waste liquid in the reaction well 1212 is then transferred to the waste liquid tank 1223 via the liquid pipette tip 10 of the second pipetting unit 300. The second pipetting unit 300 then uses the liquid pipette tip 10 to transfer the liquid required for the final nucleic acid extraction in the reaction well 1212 to the PCR tube in the amplification placement well 1221. This completes an effective nucleic acid extraction process.

[0203] To prevent cross-contamination of liquids, each transfer of liquid between the first and second pipetting units 200 and 300 requires a new liquid tip 10. In this embodiment, the liquid tips 10 for the first pipetting unit 200 are retrieved from the tip placement slot 1213 on the sample processing unit 100 and returned to the original tip placement slot 1213 after use. The liquid tips 10 for the second pipetting unit 300 are retrieved from the tip placement assembly 500 on the operating table 1. Because the second pipetting unit 300 requires frequent replacement of liquid tips 10, a tip recovery slot 400 is provided for storing used liquid tips 10.

[0204] Each sample processing unit 100 of the liquid processing device of this embodiment can simultaneously extract nucleic acids from four samples. Since the liquid processing device has four sample processing units 100, a maximum of 16 samples can be extracted at a time. This not only effectively eliminates cross-contamination between samples, but also ensures extraction results and improves efficiency. The liquid processing device is compact, easy to install, and has low manufacturing costs. It is also well-suited for large-scale application in small and medium-sized experiments and has excellent market application prospects.

[0205] Although specific embodiments of the present invention have been described above, those skilled in the art will appreciate that these are merely illustrative and that the scope of the present invention is defined by the appended claims. Those skilled in the art may make various changes or modifications to these embodiments without departing from the principles and essence of the present invention, and such changes and modifications are intended to fall within the scope of the present invention.

Claims

1. A liquid processing device, characterized in that: The liquid processing device includes an operating table, a sample processing unit, and a pipetting unit. The operating table has at least one first guide rail arranged along a first direction, and the sample processing unit is arranged on the first guide rail; the sample processing unit includes a movable table and a guide slide assembly. The movable table has a sample placement portion, a reagent placement portion, and a reaction well. The sample placement portion, the reagent placement portion, and the reaction well are arranged on the same movable table and arranged in an array along the first direction. The guide slide assembly is arranged on the lower bottom surface of the movable table. The guide slide assembly cooperates with the first guide rail, and the sample processing unit can move in the first direction. The pipetting unit is disposed above the sample processing unit, and when the sample processing unit passes below the pipetting unit, the pipetting unit can transfer the liquid in the sample placement portion and the reagent placement portion to the reaction well; The upper accommodating chamber of the reaction hole is a cylindrical structure, and the lower accommodating chamber of the reaction hole is an inwardly tightened structure from top to bottom, and the upper accommodating chamber and the lower accommodating chamber are transitioned by an arc surface; The pipetting unit includes a first pipetting unit and a second pipetting unit, and the first pipetting unit and the second pipetting unit perform pipetting operations on different liquids on the sample processing unit.

2. The liquid processing device according to claim 1, wherein The pipetting unit includes a lifting mechanism and a liquid suction mechanism. The liquid suction mechanism is fixed on the lifting mechanism and can move in a vertical direction with the lifting mechanism. The liquid suction mechanism is used to transfer the position of the liquid on the sample processing unit.

3. The liquid processing device according to claim 2, wherein: The liquid suction mechanism includes a liquid suction component and a driving member, wherein the liquid suction component includes a cylinder body with an inner cavity and a piston rod, and a liquid suction head is installed at one end of the cylinder body relative to the piston rod, and the liquid suction head is connected to the inner cavity of the cylinder body; The driving member is used to drive the piston rod to move within the cylinder body, so that the liquid suction component can suck in or discharge liquid.

4. The liquid processing device according to claim 1, wherein The operating table further has a second guide rail arranged along a second direction. The second guide rail is cross-arranged above the first guide rail. The pipetting unit is arranged on the second guide rail and can move along the second direction.

5. The liquid processing device according to claim 4, wherein: The operating table has a table top, a bracket is arranged on the table top, the first guide rail is arranged on the table top, and the second guide rail is arranged on the bracket.

6. The liquid processing device according to claim 4, wherein: The first pipetting unit is fixed above the first guide rail, and the second pipetting unit is movable on the second guide rail.

7. The liquid processing device according to claim 4, wherein: The liquid processing device also includes a suction head recovery trough. The operating table has a third guide rail arranged along a third direction. The third guide rail is cross-arranged below the second guide rail. The suction head recovery trough is arranged on the third guide rail and can move along the third direction.

8. The liquid processing device according to claim 4, wherein: The liquid processing device also includes a suction head placement assembly. The operating table has a fourth guide rail arranged along a fourth direction. The fourth guide rail is cross-arranged below the second guide rail. The suction head placement assembly is arranged on the fourth guide rail and can move along the fourth direction.

9. The liquid processing device according to claim 1, wherein The sample placement portion is provided on a side surface of the movable platform, and the side surface is perpendicular to the first direction; The reagent placement portion and the reaction well are provided on the upper end surface of the moving stage.

10. The liquid processing device according to claim 1, wherein The liquid processing device also includes a control mechanism, which is used to control the sample processing unit to move in the first direction. The control mechanism is also used to control the pipetting unit to transfer the liquid in the sample placement part and the reagent placement part to the reaction well. The control mechanism is also used to control the pipetting unit to transfer the sample product in the reaction well after the liquid processing in the reaction well is completed.

11. The liquid processing device according to claim 10, wherein: The liquid processing device further includes a code scanning unit, which is movable in a direction perpendicular to the first direction and configured to identify information about the liquid in the sample processing unit and transmit the information to the control mechanism.

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