A disinfectant containing ethanol

Abstract

The present invention relates to an ethanol disinfectant. It comprises (wt%) ethanol, surfactant: 0.03-0.05%, C12-22 alkyl alcohol: 1.5-3%, polyethylene glycol: 3-10%, water: 20-30%, propellant: 7-10%, wherein the concentration of ethanol is 60-72% (v / v). The disinfectant does not contain a gel component.

Description

Technical Field

[0001] The present invention relates to an ethanol-containing disinfection product, which comprises ethanol, a surfactant, a C12-22 alkyl alcohol, polyethylene glycol, water, and a propellant, but does not contain a gel component, and specifically relates to the technical field of disinfection. Background Art

[0002] Ethanol is a raw material widely used in the industrial field, and is also widely used as a disinfectant in the health field and daily life. Ethanol is non-toxic, non-irritating, and non-corrosive to metals; it can kill bacteria and their reproductive bodies, tuberculosis bacteria, and most fungi and viruses.

[0003] Currently, most alcohol disinfectants on the market are ethanol sprays, which are easy to spill when used. In addition, due to the high concentration of ethanol being volatile, it stays on the hands for a very short time, affecting the bactericidal and / or antiviral effects. In addition, alcohol will absorb moisture from the area where it is used, such as the skin. Frequent use can cause the skin to become dry or even cracked.

[0004] GB 26373-2010 "Hygienic Standards for Ethanol Disinfectants" stipulates that the ethanol content should be 70%~80% (V / V). The National Health Commission Supervision Letter (2020) No. 99 "Notice of the General Office of the National Health Commission on the Emergency Listing of Some Disinfectants during the Prevention and Control of Pneumonia Infected by the New Coronavirus" stipulates that the concentration of alcohol active ingredients in alcohol hand disinfectants is >60% (V / V).

[0005] US5167950 discloses a high-concentration alcohol antibacterial mousse, wherein the composition characteristics are (1) the intermediate content is 85% to 98%, and the hydrocarbon propellant is 2% to 15%; (2) the mass fraction of ethanol and isopropanol is 52% to 75%; and the mass fraction of water-dispersible polymer gel is 0.1% to 1.5%; (3) an amphoteric system, the mass fraction is 1.0% to 15%, and it is composed of the following components: (a) at least one alcohol with 16 to 22 carbon atoms, the mass fraction is 0.5% to 5%; (b) at least one non-ionic surfactant, the mass fraction is 0.5% to 10%, and the molecular formula is RO (CH2CH2O) x H, R refers to a hydrocarbon group with 16 to 22 carbon atoms, and X is 1 to 21; the HLB value of the mixture of (a) and (b) is 4.5 to 8.0, (4) the rest is composed of water, the mass fraction of which is at least 20% of the intermediate, and (5) the propellant is a saturated fatty alkane containing 2 to 6 carbon atoms. The invention adds isopropyl alcohol, which has certain safety issues for the human body, and the addition of a large amount of surfactant is not environmentally friendly.

[0006] Therefore, in the face of more and more challenges to public health and higher demands for public health prevention products, it is very necessary to seek ethanol-containing disinfection products that are safe and effective while causing the least possible harm to the human body. Summary of the invention

[0007] The present invention aims to solve the above problems and provide an ethanol-containing disinfectant that can effectively kill bacteria and / or viruses attached to the epidermis or skin of objects or mammals. The disinfectant contains 60-72% ethanol by volume and can effectively prevent possible damage to the parts of mammals caused by the ethanol-containing disinfectant, such as dry skin or wrinkles caused by applying a certain concentration of ethanol to the animal's skin. The ethanol-containing disinfectant of the present invention contains C 12-22 Alkyl alcohol, no gel ingredients.

[0008] Ethanol concentration (V / V) = [(mass of anhydrous ethanol / density of anhydrous ethanol) / (total mass of intermediates / density of intermediates)]*100%.

[0009] HLB refers to the hydrophilic-hydrophobic balance.

[0010] In the present invention, unless otherwise specified in terms of volume ratio, the percentages of other components are all weight ratios.

[0011] The first aspect of the present invention provides a method comprising 60-72% by volume of ethanol, water, C 12-22 A disinfectant composition comprising an alkyl alcohol, a surfactant, a polyethylene glycol and a propellant, and containing no gel component.

[0012] The present invention further provides a method comprising 60-72% by volume of ethanol, water, C 12-22 A disinfectant composition comprising an alkyl alcohol, a surfactant, polyethylene glycol and a propellant, and containing no gel component, wherein the surfactant can be selected from polysorbate 60 and polysorbate 80.

[0013] The present invention further provides a method comprising 60-72% by volume of ethanol, water, C 12-22 A disinfectant composition of an alkyl alcohol, a surfactant, polyethylene glycol and a propellant, wherein the surfactant is preferably polysorbate 60 with an HLB of 14.9.

[0014] According to the present invention, the disinfectant of the present invention is preferably in the form of a foam such as a mousse.

[0015] To this end, the present invention further provides a method comprising 60-72% by volume of ethanol, water, C 12-22 The invention discloses a disinfecting mousse composition containing no gel, comprising an alkyl alcohol, a surfactant, polyethylene glycol and a propellant, wherein the molecular weight of the polyethylene glycol is 4000-20000, and polyethylene glycol 6000 is preferred.

[0016] The present invention provides a method comprising 60-72% by volume of ethanol, water, C 12-22A disinfectant composition comprising an alkyl alcohol, a surfactant, polyethylene glycol and a propellant, and does not contain a gel, wherein the molecular weight of the polyethylene glycol is more preferably 6,000.

[0017] The present invention provides a method comprising 60-72% by volume of ethanol, water, C 12-22 A disinfecting mousse composition comprising an alkyl alcohol, a surfactant, polyethylene glycol 6000 and a propellant, wherein the amount of polyethylene glycol 6000 is 3% to 10%, more preferably 6% to 7%.

[0018] According to the present invention, C 12-22 The alkyl alcohol can be selected from a mixture of one or more of lauryl alcohol, tetradecanol, hexadecanol, octadecanol, and behenyl alcohol, preferably a mixture of octadecanol and behenyl alcohol, wherein the ratio of octadecanol to behenyl alcohol is 1.3 to 2.5:1, and more preferably the ratio of octadecanol to behenyl alcohol is about 2:1.

[0019] The present invention further provides a method for preparing an ethanol disinfectant composition, comprising the following steps:

[0020] (a) Dissolve a surfactant such as polysorbate 60 in a small amount of anhydrous ethanol.

[0021] (b) Heat the remaining anhydrous ethanol to 50°C and add polyethylene glycol, C 12-22 Alkyl alcohol and the solution in step a, stir until completely dissolved.

[0022] (c) Add water to the above solution and stir well.

[0023] (d) Filling, sealing and adding propellant.

[0024] (e) A disinfectant having an ethanol concentration of 60-72% (v / v) is obtained.

[0025] The disinfectant of the present invention has the following characteristics: first, the effective concentration of ethanol is high, and the maximum ethanol concentration can reach 72% (intermediate), which can effectively kill various microorganisms such as bacteria or viruses; second, when the disinfectant exists in the form of mousse, the sprayed foam has good formability, which solves the problem that ethanol is easy to spray and drip during use and cannot be effectively applied to the application surface such as skin, so as to achieve the purpose of effectively killing microorganisms; third, while killing microorganisms, a protective film is formed on the application site such as the skin surface, ensuring the protection of the application site such as the skin during use, such as the skin will not dry out due to water loss. Specific embodiments

[0026] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments.

[0027] Example 1

[0028]

[0029] (a) Dissolve polysorbate 60 in 150 g of anhydrous ethanol.

[0030] (b) Heat the remaining anhydrous ethanol to 50° C., add polyethylene glycol octadecyl alcohol, behenyl alcohol, polyethylene glycol 6000 and the solution in step a, and stir until completely dissolved.

[0031] (c) Add water to the above solution and stir well.

[0032] (d) Filling, sealing and adding propellant.

[0033] (e) Properties: When the foam is sprayed onto the skin, it is fine and complete, has good holding power, and can maintain this state for at least 1 minute.

[0034] Example 2

[0035]

[0036] (a) Dissolve polysorbate 60 in 150 g of anhydrous ethanol.

[0037] (b) Heat the remaining anhydrous ethanol to 50° C., add polyethylene glycol octadecyl alcohol, behenyl alcohol, polyethylene glycol 6000 and the solution in step a, and stir until completely dissolved.

[0038] (c) Add water to the above solution and stir well.

[0039] (d) Filling, sealing and adding propellant.

[0040] (e) Properties: When the foam is sprayed onto the skin, it is fine and complete, has good holding power, and can maintain this state for at least 3 minutes.

[0041] Example 3

[0042] Comparison of the killing effect of homemade Example 1 and medical ethanol disinfectant on Staphylococcus aureus

[0043]

[0044] The disinfectant obtained in Example 1 and the medical ethanol disinfectant can achieve the same killing effect on Staphylococcus aureus

[0045] Example 4

[0046] After using the disinfectant obtained in Example 1 and the medical ethanol disinfectant solution for 3 consecutive times, the skin moisture score was tested with an intelligent multifunctional skin detector. The number of test participants was n=7.

[0047]

[0048] The skin moisture score after using the disinfectant obtained in Example 1 was significantly higher than that after using the medical ethanol disinfectant (P<0.05). The use of the homemade ethanol disinfectant (foam type) had a certain moisturizing effect on the hand skin, while the use of the medical ethanol disinfectant would cause the skin to lose moisture and cause dry skin.

[0049] Example 5

[0050] The evaporation time of the disinfectant obtained in comparative example 1 and the medical ethanol disinfectant on the hands is n=7.

[0051]

[0052] The disinfectant obtained in Example 1 has a longer evaporation time on the hands, which can extend the sterilization time.

Claims

1. An aerosol foam disinfectant containing ethanol, characterized in that It contains 60-72% v / v of ethanol, 0.03% to 0.05% m / v of polysorbate 60, 1.5% to 3% m / v of a mixture of octadecyl alcohol and behenyl alcohol, 3% to 10% m / v of polyethylene glycol 6000, 20% to 30% m / v of water, and 7% to 10% m / v of tetrafluoroethane.

2. The ethanol-containing aerosol foam disinfectant according to claim 1, wherein the ethanol concentration v / v is 70%.

3. The ethanol-containing aerosol foam disinfectant according to claim 1, wherein the ratio of octadecyl alcohol to docosanol is 1.3 to 2.5:

1.

4. The ethanol-containing aerosol foam disinfectant according to claim 3, wherein the ratio of octadecyl alcohol to docosanol is 2:

1.

5. The ethanol-containing aerosol foam disinfectant according to claim 1, characterized in that Contains ethanol 70% v / v, polysorbate 60: 0.046% m / v, octadecyl alcohol: 1.7% m / v, behenyl alcohol: 0.83% m / v, polyethylene glycol 6000: 9.2% m / v, water: 23% m / v, tetrafluoroethane: 8.2% m / v.

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