Application flow path for water treatment or detection

Abstract

The application relates to the field of liquid treatment, and discloses an application flow path for water treatment or detection, which comprises at least one common pipeline, a plurality of devices for quantitatively treating liquid are connected in parallel on the common pipeline, at least one device for quantitatively treating liquid comprises: a container for containing liquid to be extracted; a through-flow pipeline which extends from the inside of the container to a branching point, a peristaltic pump is arranged in series on the through-flow pipeline; a second branch which communicates with the through-flow pipeline and extends from the branching point to a second port, a peristaltic pump is arranged in series on the second branch, and the second port is communicated to the common pipeline; and a first branch which communicates with the through-flow pipeline and extends from the branching point to a first port which is communicated to the atmosphere.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of liquid treatment, analysis or detection, and in particular, to an application flow path for water treatment or detection. BACKGROUND

[0002] Currently, in many technical fields, the treatment and / or analysis of liquids is involved. For example, in the medical field, the food field, laboratory analysis, agriculture, forestry, animal husbandry, fishery and other fields, the analysis of samples requires quantitative treatment of the sample to be tested and reagents. For another example, in the field of environmental protection, water quality detection requires intercepting a small amount of sample and detecting and analyzing the small sample. The accuracy of the amount of liquid to be tested has a direct and important impact on the detection result. If the sample cannot be accurately intercepted or the volume of the liquid is not accurately known, it will result in a large error in the detection result.

[0003] Traditionally, many analysis instruments or liquid treatment devices can accurately add a small volume of liquid (such as 0.05 milliliters to 2 milliliters), but the object to be detected is usually a relatively clear and clean liquid after pretreatment such as flocculation, precipitation and filtration in a laboratory state, and the cost of liquid pretreatment device and manual operation is usually high.

[0004] This traditional solution is difficult to meet the actual working condition requirements of the current industry, because it is difficult to ensure the cleanliness of the liquid to be tested in some actual working conditions. On the other hand, once the liquid to be tested is pretreated, the clean liquid is obviously different from the actual liquid in the first field (such as COD, total phosphorus, total nitrogen, etc. in water quality detection), which may affect the accuracy of the measurement, and the suspended solids or impurities in the liquid may also block the pretreatment pipeline. For another example, in the field of online monitoring in harsh conditions, such as online detection of electroplating treatment liquid, wet smelting mineral solution, environmental pollution wastewater, etc., the traditional technical solution cannot realize accurate quantitative detection of the harsh liquid to be tested in such working conditions. In particular, there is a lack of a micro-liquid (such as 0.05-2 milliliters) quantitative technology with relatively low cost and relatively long time maintenance or even maintenance-free.

[0005] Furthermore, a typical quantitative metering flow path widely used in analytical instruments and liquid handling is the "sequential injection" metering technology. This flow path technology has good stability, but in the past decade, with the emergence of stringent new demands for low cost, high precision, and the ability to handle both micro-volume (e.g., 0.05-2 ml) and conventional volume (e.g., 2-10 ml) metering, as well as rapid measurement and detection, several inherent drawbacks of the traditional sequential injection metering technology have become increasingly apparent. For example, firstly, the cost of the flow path components in such traditional devices is high due to the need for multi-channel switching valves (or valve assemblies) and metering detection devices; secondly, in this type of traditional device, the inlet and outlet of the liquid need to be carried out sequentially via a transfer mechanism, thus the operation steps are relatively complex. The process is complex and time-consuming, resulting in relatively low overall work efficiency. Furthermore, a more serious drawback is that if certain operating conditions require continuous water sample and several different reagents, the flow path in traditional solutions can only measure these samples and reagents sequentially. Moreover, sometimes the pipeline needs thorough cleaning before introducing the next reagent, leading to excessively long overall analysis time and severely impacting work efficiency. Finally, in the flow path of traditional devices, the long transit pipeline makes it easy for liquid to adhere to the walls or remain inside the conduits and devices, resulting in low measurement accuracy when performing micro-volume processing.

[0006] In view of this, how to overcome at least some of the technical defects mentioned above in traditional solutions has become an urgent technical problem that needs to be solved in this field. Summary of the Invention

[0007] To achieve the above objectives, this application provides an application flow path for water treatment or detection, the application flow path comprising:

[0008] At least one common pipeline, on which multiple devices for metering liquid are connected in parallel, wherein at least one device for metering liquid includes:

[0009] A container used to hold the liquid to be extracted;

[0010] A flow passage extends from the inside of the container outward to the bifurcation point, and a peristaltic pump is connected in series in the flow passage.

[0011] A second branch, which connects to the flow path and extends from the bifurcation point to a second port, is equipped with a peristaltic pump connected in series in the second branch, and all second ports are connected to the common pipeline; and

[0012] The first branch is connected to the flow path and extends from the bifurcation point to the first port leading to the atmosphere.

[0013] Preferably, the first branch and / or the second branch is / are a fine channel having an inner diameter of 0.05 mm to 5 mm, preferably 0.1 mm to 3 mm, more preferably 0.2 mm to 2 mm.

[0014] Preferably, at least a portion of the common channel is a fine channel.

[0015] Preferably, the through channel is also a fine channel; or the through channel is a fine channel within a predetermined length range extending from the branching point towards the container, the predetermined length range being at least 0.01 mm.

[0016] Preferably, the application flow path comprises a reactor / dish, and the common channels are all connected to the reactor / dish.

[0017] Preferably, the opening of the common channel is located at the bottom, middle or upper portion of the reactor / dish; and / or the common channel drops liquid into the reactor / dish through an opening above the top of the reactor / dish; and / or the liquid in the container is distilled water, cleaning liquid, water sample to be tested, standard solution or reagent.

[0018] Preferably, the common channel comprises one common channel, and the opening of the one common channel is located at the bottom of the reactor / dish.

[0019] Preferably, the application flow path for water treatment or detection comprises at least one outer branch, and each of the common channels is connected to the atmosphere through an outer branch provided with a peristaltic pump in series, for pumping in and / or pumping out air, and / or discharging liquid.

[0020] Preferably, the outer branch comprises a first outer branch connected to the common channel to the atmosphere, wherein preferably the first outer branch is connected to the portion of the common channel between the end portion away from the reactor / dish and the node of each second branch connected to the container containing reagent, or wherein preferably the first outer branch is connected to the portion of the common channel between the end portion away from the reactor / dish and the node of the second branch connected to the container containing distilled water, preferably the first outer branch is connected to the end portion of the common channel away from the reactor / dish.

[0021] Preferably, the application flow path comprises a liquid detector provided in the portion of the common channel between the reactor / dish and the node of the through channel and the common channel closest to the reactor / dish.

[0022] Preferably, the outer branch includes a second outer branch provided with a peristaltic pump in series and having an air / washing water / waste liquid discharge port open to the atmosphere, and the second outer branch is connected to the portion of the common pipeline between the reactor / well and the node of the through pipeline and the common pipeline closest to the reactor / well.

[0023] Preferably, the common pipeline further includes another common pipeline, and the plurality of liquid quantification treatment devices are respectively and in parallel connected to the one common pipeline and the other common pipeline, and the other common pipeline is connected to and / or extends into the interior of the reactor / well or above the opening of the reactor / well, and the opening of the common pipeline is arranged adjacent to the bottom opening of the reactor / well.

[0024] Preferably, the other common pipeline is connected to the atmosphere through a third outer branch provided with a peristaltic pump in series.

[0025] Preferably, the containers of part of the plurality of liquid quantification treatment devices are arranged in parallel and each has a common first branch and a second branch through a respective peristaltic pump, and the second port of the second branch is connected to the one common pipeline.

[0026] Preferably, the containers of part of the plurality of liquid quantification treatment devices are arranged in parallel and each has a common first branch and a second branch through a respective stop valve in series with a peristaltic pump, and the second port of the second branch is connected to the one common pipeline.

[0027] Preferably, the application flow path includes a plurality of containers connected to the common pipeline through a selection valve.

[0028] Preferably, the first port of the first branch of part of the plurality of liquid quantification treatment devices is open to the container of the device, and the container contains a reagent.

[0029] Preferably, the reactor / well is provided with a detector for detecting the liquid level or liquid capacity in the interior of the reactor / well, and the detector is a dielectric sensor, a pressure sensor or an optical sensor.

[0030] Through the technical solution of the present application, the working characteristics of the peristaltic pump and / or the stop valve can be utilized, and at least part of the following beneficial technical effects can be achieved.

[0031] For example, by using a combination of peristaltic pump and / or stop valve, the liquid to be metered into the liquid can be easily filled in the selected constant volume pipeline by overflow, and the liquid can be accurately measured by simple control of the peristaltic pump and stop valve. In addition, the air bubbles that may be generated at the beginning of the liquid can be eliminated by the overflow method, so that high-precision liquid can be realized under micro-liquid volume. In addition to accurately measuring the volume of the liquid to be measured, the technical solution of the present application can also realize high-precision measurement and rapid liquid feeding of the liquid, and can also deliver the liquid with high-precision volume to the subsequent processing container or process.

[0032] For example, the flow path topology in the technical solution of the present application is very simple, the types of flow path devices required are less, and the devices are simple and easy to mass produce, some flow paths even only require one device (peristaltic pump) in addition to the conduit, so the cost is greatly reduced, the assembly is very simple during production and manufacturing, and the daily maintenance and repair is also very convenient during use.

[0033] In addition, in the technical solution of the present application, most of the devices used are currently widely used and produced in the industrial field (small and micro peristaltic pumps and stop valves), and a cheap fine channel is preferably used as a constant volume pipe. Such devices are not only cheap, but also stable and reliable in performance. Therefore, compared with the traditional scheme, the cost can be greatly reduced and good reliability can be obtained.

[0034] In addition, in the technical solution of the present application, as described above, high-precision constant volume measurement can be realized by using the flow path scheme design, and higher-precision liquid feeding operation can be realized by using the peristaltic pump (since the peristaltic pump pipe is preferably directly connected to the fine channel, compared with the stop valve, the peristaltic pump can more easily eliminate the dead volume interference problem of residual liquid).

[0035] In addition, in the present application, not only can various flow path schemes be easily expanded and modularly combined, but also a "concurrent micro-equivalent rapid liquid feeding technology" similar to "magazine loading" can be realized in some combined flow path schemes: in the traditional sequential liquid feeding mode (such as "sequential injection" liquid feeding technology), the constant volume measuring device and the peristaltic pump can usually only have one, so the water sample or reagent must be driven by the peristaltic pump to enter the constant volume measuring device in turn, and finally pushed or sucked into the specified container or pipeline; in the preferred embodiment of the present application, the "concurrent micro-equivalent rapid liquid feeding technology" (such as the application of flow path Figures 21-24 、 Figures 33-42 etc.), the water sample and various reagents can be pre-constant in the respective branches, and then driven by the pumps on the branches at the same time or in turn, or driven by the pumps in the main pipeline in turn, and injected into the reactor / pan, which greatly saves the total time for completing all reagent metering and subsequent cleaning.

[0036] In addition, the "sequential injection" liquid feeding technique requires that the water sample or reagent be first pumped into the quantitative tube for temporary volume adjustment, and then the water sample or reagent in the quantitative tube is pumped into the pre-determined container (such as a cuvette) for detection. After the detection is completed, the waste liquid needs to be discharged in a reverse process. Such operation not only takes time, but also increases the risk of residual liquid in the flow path. In the preferred embodiment of the present application, the flow path does not need to be provided with a liquid storage unit, and the flow path scheme in each combined flow path can independently allow the to-be-detected liquid (such as a water sample) and the reagent to directly enter the cuvette leading to the reaction container, so that the liquid feeding and volume metering can be completed at the same time, and the liquid discharging is also simpler, which only needs to continuously and rapidly discharge the liquid to the waste liquid outlet. Moreover, due to the improvement of the metering accuracy, the volume of the liquid fed by the present application is greatly reduced, and the flow path stroke is greatly shortened. Therefore, compared with the traditional method, the liquid feeding time is greatly shortened, and the work efficiency is improved; and since the core components such as the plunger pump and the metering quantitative tube are reduced, the cost is greatly reduced, and the size of the device is also reduced, thereby realizing miniaturization and portability.

[0037] Other features and advantages of the present application will be described in detail in the following specific embodiments. BRIEF DESCRIPTION OF DRAWINGS

[0038] The accompanying drawings are included to provide a further understanding of the present application, and constitute a part of the specification, and together with the following specific embodiments, serve to explain the present application, but do not constitute a limitation on the present application. In the drawings:

[0039] Figures 1A-1E and Figures 2-10 are respectively schematic diagrams of various basic flow path schemes of the device for quantitatively processing liquid according to the present application.

[0040] Figures 11A-11C and Figure 12 are respectively schematic diagrams of various basic flow path schemes of the device for quantitatively processing liquid according to the present application.

[0041] Figures 17-43 are respectively schematic diagrams of various reaction flow paths of the device for quantitatively processing liquid according to the present application.

[0042] Figure 44 is a schematic diagram for expressing the technical advantages of the fine channel in use in the technical scheme of the present application. DETAILED DESCRIPTION

[0043] In the technical solution of the present application, the basic flow path of the device for quantitatively processing liquid, the combination of the basic flow path, and various application flow paths are described. It can be understood that in actual engineering applications, various modes of liquid flow control can be realized by combining the flow path solution of the technical solution of the present application under the control of various elements in a computer system (such as an industrial computer, a single-chip microcomputer, etc.). The selection of the control unit and the program design can be selected according to the actual working conditions.

[0044] As described above, the technical solution of the present application can be applied to various technical fields related to liquid processing and / or analysis, such as the medical field, the food field, laboratory analysis, but is particularly suitable for water quality detection and analysis in the environmental protection field. For example, the technical solution of the present application is particularly suitable for a water quality analyzer.

[0045] The specific embodiments of the present application are described in detail below with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are only used to illustrate and explain the present application, and are not used to limit the present application.

[0046] I. Definitions

[0047] 1. Fine channel or fine tube

[0048] In the preferred technical solution of the present application, a part of the flow path is designed as a fine channel. For example, the first branch and / or the second branch are fine channels, and the inner diameter of the fine channel is 0.05mm to 5mm, preferably 0.1mm to 3mm, and more preferably 0.2mm to 2mm. Preferably, at least a part of the common pipeline is a fine channel. Preferably, the through-flow pipeline is also a fine channel; or the through-flow pipeline is a fine channel within a predetermined length range from the branch point b1, c1, r2, …, r2n to the container Pb, Pc, Pd, Pr1, …, Prn, and the predetermined length range is at least 0.01mm.

[0049] In addition, the flow path generally has a uniform inner diameter; but within the range of precision allowed or the position of the setting element (such as a peristaltic pump or a stop valve, etc.), different inner diameters can also be designed.

[0050] The material of the fine channel includes but is not limited to various rubbers, plastics or metals, etc. The fine channel can be a fine tube, and commonly used tubes include silicone rubber tubes, fluororubber tubes, polytetrafluoroethylene tubes, etc.

[0051] It should be noted that in this paper, for the sake of convenience, the "channel" is referred to as "pipeline" or "conduit".

[0052] In the preferred technical solution of the present application, the fine channel design is adopted based on the following reasons.

[0053] As mentioned above, by using the fine channel (combined with simple control of peristaltic pump and / or stop valve), not only high-precision constant volume under micro-liquid volume can be realized, but also high-precision micro-liquid feeding (such as 0.1-2 milliliters) can be realized. For example, if a fine channel with an inner diameter of 0.5 mm and a length of 500 mm is selected for constant volume, the technical solution of the present application can easily realize constant volume measurement of about 100 microliters (0.1 milliliter) of sewage, with a precision of ±2 microliters, and then the high-precision constant volume liquid can be delivered without residue. In addition, since the fine channel is used, the liquid sample with smaller volume can be processed and detected subsequently, which greatly reduces the cost of reagents consumed.

[0054] More importantly, in the field of online monitoring under harsh conditions, the use of the above fine channel (the optimal selection of the inner diameter is 0.5-1.6 mm) has three outstanding advantages. First, the fine channel is relatively easy to plug and repair, and the cost of regular replacement is very low, which is particularly important for online monitoring instruments under harsh conditions. Second, for liquids that have been coarsely filtered, such a pipe diameter can basically avoid pipe blockage caused by suspended solids or impurities in the liquid, ensuring the stability of the flow path. Third, when the conduit is fine enough, its inner diameter will be smaller than the height of the liquid droplet formed inside the conduit due to surface tension and wetting. At this time, the liquid will naturally converge and close the fine channel, and under the drive of the pump, the above liquid can be slowly sent into the target container, thereby avoiding or reducing the amount of liquid that affects the precision in the pipeline. If the hole diameter of the conduit is designed to be too large, the liquid will be difficult to be removed by the external blowing gas because the maximum radial size of the liquid droplet of the residual liquid in the pipe wall is difficult to reach the height of the pipe diameter, so even if the gas is blown in, it is difficult to more thoroughly remove the residual liquid on the pipe wall due to the existence of the gap, as shown in Figure 44 In the technical solution of the present application, by selecting the above inner diameter size range of the fine channel, the maximum radial size of the liquid droplet formed by the residual liquid on the pipe wall can reach or exceed the height of the pipe diameter (as shown in Figure 44 Therefore, the residual liquid on the pipe wall can be more thoroughly removed by the blowing fluid (such as liquid or gas), and the defect that the impurities in the liquid to be measured in the field of online monitoring under harsh conditions are easy to block the pipe can be avoided.

[0055] It can be understood that, although the use of thin channels is emphasized in the preferred embodiments of the present application, this does not mean that other non-thin channel devices that can be combined into various complex channel combinations in the present application are excluded, for example, the combination use of pipes with larger inner diameters, without affecting the purpose of achieving the present application, thin channels or thin flow channels can not be used, but at least in part, pipes with larger inner diameters are used, such as coarse constant volume pipes (see Figures 29-32 ) when a constant volume of a conventional volume of more than 2 milliliters is required, and coarse pipes connected to the liquid outlet for discharging waste liquid. In this way, not only is the wiring flexible and low in cost, but also maintenance is convenient during later use. In addition, although the thin channels are introduced above by taking the conduit as an example, it can be understood that, under the premise of meeting the above inner diameter size range, the thin channels in the present application are not limited to this form of conduit, but can also be other forms, such as organic multi-way board, microfluidic chip groove, etc.

[0056] 2. Peristaltic pump

[0057] In the technical solutions of the present application, the peristaltic pump is a general definition of a device or device combination with the function of a peristaltic pump. Without special instructions, it refers to a device or device combination that can drive liquid in both forward and reverse directions (sometimes only in one direction), and can cut off and close the pipe when stationary. The above general peristaltic pump includes but is not limited to the following specific devices or device combinations: a narrow-sense peristaltic pump; a series combination of a shut-off valve and a pump (sometimes only in one direction) or a pump group (for example, a combination of several diaphragm pumps, centrifugal pumps, etc.) that can drive fluid in both forward and reverse directions, etc.

[0058] 3. Shut-off valve

[0059] In the technical solutions of the present application, the shut-off valve is a general definition of a device or device combination with the function of being able to cut off and close a certain pipe, including but not limited to the following specific devices: a diaphragm type two-way shut-off valve; a pinch type two-way shut-off valve (referred to as a pinch valve); a narrow-sense peristaltic pump (equivalent to closed when stationary, and equivalent to open when rotating); a rotary switching type two-way or multi-way valve, etc.

[0060] 4. N-to-1 multi-channel valve (where N is a natural number greater than or equal to 2)

[0061] In the technical solutions of the present application, the N-to-1 multi-channel valve is a general definition of a device or device combination, which has one common port and N distribution ports. Through a control signal, the common port can be uniquely connected to one of the N distribution ports or all of them can be disconnected. The above general N-to-1 multi-channel valve includes but is not limited to the following specific devices or device combinations: a valve group in which N shut-off valves are connected to the same common port; a multi-channel rotary switching valve (see Figure 35) ; other valve groups composed of multiple stop valves and multiple multi-channel switching valves, etc.

[0062] II. Basic flow path scheme

[0063] As shown in Figures 1A-1E and Figures 2-10 , the present application provides a device (basic flow path scheme) for quantitatively processing liquid, which comprises:

[0064] a container P for containing liquid to be extracted; and

[0065] a through-flow line 10 extending from the inside of the container P to a branching point a;

[0066] a first branch 11 communicating with the through-flow line 10 and extending from the branching point a to a first port K1; and

[0067] a second branch 12 communicating with the through-flow line 10 and extending from the branching point a to a second port K2;

[0068] wherein a peristaltic pump B1 is arranged in series in at least one of the through-flow line 10, the first branch 11 and the second branch 12, and a stop valve F1, F2 or another peristaltic pump B2 is arranged in series in at least one other of the through-flow line 10, the first branch 11 and the second branch 12, so as to be able to intercept a predetermined segment volume of liquid between the branching point a and the first port K1 or the second port K2.

[0069] Preferably, the first branch 11 and / or the second branch 12 is a fine channel (especially when the first branch 11 is used to quantitatively intercept a predetermined volume of liquid, preferably a fine channel; when the second branch is used to quantitatively intercept a predetermined volume of liquid, preferably a fine channel), the pore size of the fine channel being 0.05mm to 5mm, preferably 0.1mm to 3mm, and more preferably 0.5mm to 2mm; further preferably, the through-flow line 10 is also a fine channel; or the through-flow line 10 is a fine channel within a predetermined length range extending from the branching point a towards the container P, the predetermined length range being at least 0.01mm. By designing the through-flow line 10 as a fine channel within a predetermined length range extending from the branching point b1 towards the container P, better reliability and accuracy can be achieved when the first branch 11 and the second branch 12 are used to accurately intercept a predetermined segment volume of liquid, especially avoiding the situation that at least part of the liquid flows into the through-flow line 10 or even backflows into the container P when the liquid flows through the branching point a.

[0070] The container P is used to contain the liquid to be treated or analyzed. The container P can be made of various suitable materials, such as glass or plastic. The capacity of the container P can be designed according to the specific working conditions, and the maximum capacity of the container P is usually 100-2000 ml. In addition, the container P can be open, i.e. communicating with the atmosphere, or closed, i.e. not directly communicating with the atmosphere. These two forms will be described in detail in the following embodiments.

[0071] One end of the throughflow line 10 is located in the container P and extends outward to the branching point a. From the branching point a, the throughflow line 10 branches into a first branch 11 and a second branch 12. The first branch 11 has a first port K1, and the second branch 12 has a second port K2.

[0072] It should be noted that the "first" and "second" and the like (such as the first branch and the second branch here) in this application are only used to distinguish different similar or similar technical features, and do not constitute a substantial limitation on the technical solution. For example, in different working conditions, a first feature can be exchanged with a second feature, or even first, second, third, etc. can be used to distinguish similar or similar but different technical features or elements, components, parts, etc.

[0073] In order to accurately obtain the liquid sample to be treated or detected, a peristaltic pump B1 is arranged in series in at least one of the throughflow line 10, the first branch 11 and the second branch 12, and a stop valve F1, F2 or another peristaltic pump B2 is arranged in series in at least one of the throughflow line 10, the first branch 11 and the second branch 12, so as to intercept a predetermined volume of liquid between the branching point a and the first port K1 or the second port K2. Specifically, in the throughflow line 10, the first branch 11 and the second branch 12, a peristaltic pump is arranged in series in at least one of them, and a stop valve or another peristaltic pump is arranged on at least one of them. Among them, the peristaltic pump serves as a power source for pumping or pushing liquid. When the peristaltic pump is rotating, it can extract the liquid in the container P, and also can pump out the liquid after accurate determination; at the same time, when the peristaltic pump stops rotating, it can also be used for the function of stopping. Therefore, the cooperation of the peristaltic pump and the stop valve can accurately intercept a predetermined volume of liquid sample between the branching point a and the first port K1 or the second port K2, so as to obtain an accurate liquid sample. In the following, the interception process will be described in detail.

[0074] Based on the technical scheme of the innovative concept of the present application, there are many preferred embodiments, mainly in the various arrangement and combination modes between the through-flow pipeline 10, the first branch 11 and the second branch 12 and the peristaltic pump and the stop valve. Specifically, one of the peristaltic pump, the stop valve and the no-element setting (through pipeline) can be selected in the three of the through-flow pipeline 10, the first branch 11 and the second branch 12, so there are 3*3*3 = 27 combination modes in total, and the combination mode in which the three of the through-flow pipeline 10, the first branch 11 and the second branch 12 are all stop valves or all no-element settings (because the mode in which the three are all stop valves or all no-element settings is not applicable) needs to be excluded, so there are 25 combination modes in total. These combination modes are all within the scope of the present application.

[0075] In the following, the structural composition, connection relationship, operation process and technical advantages of each preferred embodiment will be described with reference to the exemplary illustrations in the drawings.

[0076] Figures 1A-1E and Figures 2-10 The various embodiments of a single device are mainly described. For convenience of description, the present application stipulates the naming and definition of various types of basic flow paths, which are divided into two parts and connected by a “-” sign. For example, “1A-basic type” represents the basic flow path shown in Figure 1A “2-basic type” represents the basic flow path shown in Figure 2 and so on. In addition, since there are five variations of the basic type of Figures 1A-1E , all of which have the same principle or are relatively similar, we use “1-basic type” to represent the five basic flow paths shown in Figures 1A-1E , and generally take “1A-basic type” as an example for explanation.

[0077] Next, the structural composition and connection relationship of each type of basic flow path will be described. For the sake of brevity, the present application only schematically draws part of the basic flow paths in the description of the basic type.

[0078] As shown in Figures 1A-1E and Figures 2-6 , the basic flow path can have various connection forms.

[0079] For example, as shown in Figure 1A and Figure 1B , the first peristaltic pump B1 is arranged in series in the first branch 11, the first stop valve F1 is arranged in series in the through-flow pipeline 10, and the second stop valve F2 or the second peristaltic pump B2 is arranged in series in the second branch 12.

[0080] For example, as shown in Figure 1C and Figure 1DAs shown, the first peristaltic pump B1 is connected in series in the first branch 11, the third peristaltic pump B3 is connected in series in the flow passage 10, and the second peristaltic pump B2 or the second shut-off valve F2 is connected in series in the second branch 12.

[0081] For example Figure 1E As shown, the third peristaltic pump B3 is connected in series in the flow passage 10, the first shut-off valve F1 is connected in series in the first branch 11, and the second peristaltic pump B2 (not shown) or the second shut-off valve F2 is connected in series in the second branch 12.

[0082] For example Figure 2 and Figure 3 As shown, the first peristaltic pump B1 is connected in series in the first branch 11, the flow passage 10 is a flow pipe, and the second shut-off valve F2 or the second peristaltic pump B2 is connected in series in the second branch 12.

[0083] For example Figures 4-6 As shown, the first branch 11 is a through pipe, the second branch 12 is connected in series with the second peristaltic pump B2 or the second shut-off valve F2, and the flow through pipe 10 is connected in series with the first peristaltic pump B1.

[0084] The following is about Figures 1A-1E as well as Figures 2-10 The basic flow path shown is described in more detail below.

[0085] Embodiment One

[0086] like Figures 1A-1E As shown, the structure and connection relationship of the device for quantitative liquid processing are as follows.

[0087] Container P is used to contain the liquid to be extracted, and container P is open to the atmosphere. A flow path 10 extends outward from the inside of container P (preferably upward) and extends to a branch point a. At this branch point a, the flow path 10 splits into a first branch 11 and a second branch 12. The first branch 11 extends from the branch point a to a first port K1, and the second branch 12 extends from the branch point a to a second port K2.

[0088] In each flow path 10, the first branch 11, and the second branch 12, a peristaltic pump or a shut-off valve is connected in series, and at least one of the flow paths 10, the first branch 11, and the second branch 12 has a peristaltic pump connected in series. Below are descriptions of several different "1-basic type" flow paths:

[0089] like Figure 1AThe “1A-basic type” basic flow path shown has a first shut-off valve F1 connected in series in the flow path 10, a first peristaltic pump B1 connected in series in the first branch 11, and a second shut-off valve F2 connected in series in the second branch 12.

[0090] Figure 1A The working process of the illustrated embodiment is as follows.

[0091] First, open the first shut-off valve F1 while keeping the second shut-off valve F2 closed. Then, rotate the first peristaltic pump B1 clockwise (based on the orientation shown in the figure, but not as a limitation of this application). At this time, the liquid in container P enters the flow passage 10 under the pumping of the first peristaltic pump B1, passes through the first shut-off valve F1 and the first peristaltic pump B1, and then overflows through the first port K1.

[0092] Then, the first shut-off valve F1 closes, and the second shut-off valve F2 opens, causing the first peristaltic pump B1 to rotate counterclockwise. At this time, air enters through the first port K1, allowing a section of liquid with a constant volume between the bifurcation point a and the first port K1 to be removed from the first port K2. Alternatively, if the first peristaltic pump B1 is rotated clockwise, air enters through the second port K2, allowing a section of liquid with a constant volume between the bifurcation point a and the first port K1 to be removed from the first port K1.

[0093] like Figure 1B The "1B-basic" basic flow path shown is related to... Figure 1A The main difference in the "1A-basic type" basic flow path shown is that the second shut-off valve F2 is replaced by the second peristaltic pump B2. Therefore, when the second peristaltic pump B2 is stationary, it can act as a shut-off valve. Using the liquid inlet operation procedure of the "1A-basic type" flow path, liquid can be metered and brought to volume in the first or second branch pipe. When it is necessary to remove the liquid with a constant volume in the section of pipe between the bifurcation point a and the first port K1 or the second port K2, the first peristaltic pump B1 and the second peristaltic pump B2 can be driven in the same direction but at different speeds to remove the liquid from the first port K1 or the second port K2. In this scheme, the components on the first branch 11 and the second branch 12 are preferably designed to be interchangeable, but different peristaltic pumps are also possible.

[0094] like Figure 1C The "1C-basic type" basic flow path shown is related to... Figure 1AThe main difference in the "1A-basic type" flow path shown is that the first shut-off valve F1 is replaced by the third peristaltic pump B3. Therefore, when the third peristaltic pump B3 is stationary, it can act as a shut-off valve. Using the "1A-basic type" flow path, the liquid can be metered and brought to volume in the first or second branch pipe. When it is necessary to remove the liquid from the section of pipe between the bifurcation point a and the first port K1 or the second port K2, the first peristaltic pump B1 and the third peristaltic pump B3 can be driven in the same direction but at different speeds to remove the liquid from the first port K1 or the second port K2.

[0095] like Figure 1D The "1D-basic" basic flow path shown is related to... Figure 1A The main difference in the "1A-basic type" basic flow path shown is that the first shut-off valve F1 and the second shut-off valve F2 are replaced by the third peristaltic pump B3 and the second peristaltic pump B2, respectively. Therefore, when the second peristaltic pump B2 or the third peristaltic pump B3 is stationary, it can act as a shut-off valve. Using the liquid inlet operation procedure of the "1A-basic type" flow path, liquid can be metered and brought to volume in the first or second branch pipe. When it is necessary to remove the liquid from the section of pipe between the bifurcation point a and the first port K1 or the second port K2, the first peristaltic pump B1 and the second peristaltic pump B2 can be driven in the same direction but at different speeds to remove the liquid from the first port K1 or the second port K2.

[0096] like Figure 1E The “1e-basic type” basic flow path shown has a third peristaltic pump B3 connected in series in the flow path 10, a first shut-off valve F1 connected in series in the first branch 11, and a second shut-off valve F2 connected in series in the second branch 12.

[0097] Figure 1E The working process of the illustrated embodiment is as follows.

[0098] First, open the first shut-off valve F1 while keeping the second shut-off valve F2 closed. Then, rotate the third peristaltic pump B3 counterclockwise (based on the orientation shown in the figure, but not as a limitation of this application). At this time, the liquid in container P is drawn into the flow passage 10 by the third peristaltic pump B3, passes through the third peristaltic pump B3 and the first shut-off valve F1, and then overflows through the first port K1.

[0099] Then, the first shut-off valve F1 opens, the first peristaltic pump B1 remains stationary, and the second shut-off valve F2 opens. At this time, air enters from the first port K1, and the constant-volume liquid in the section of pipe between the bifurcation point a and the first port K1 is removed from the second port K2 under the influence of gravity. Similarly, due to the preferred narrow-channel design, when the third peristaltic pump B3 remains stationary and the second shut-off valve F2 is closed, the constant-volume liquid in the section of pipe between the bifurcation point a and the first port K1 will not flow downwards on its own; instead, it will flow out under gravity only after the second shut-off valve F2 is opened.

[0100] As described above, since the peristaltic pump has two rotational directions, it can be used to both pump liquid from the container P and discharge the liquid from the corresponding port. The characteristics of the various basic flow paths shown in Figure 1 are: in the three branches—the flow path, the first branch, and the second branch—each branch must have at least one peristaltic pump or shut-off valve connected in series, and there must be at least one peristaltic pump connected in series on one branch.

[0101] according to Figures 1A-1E The illustrated embodiment enables the extraction of a predetermined volume of liquid sample with high efficiency and relatively high accuracy in determining the volume of the obtained liquid sample. Furthermore, since the inner diameter of the narrow channel is preferably small, the volume of the liquid sample extracted is also relatively small. The size of the liquid volume to be extracted can be determined by adjusting the lengths of the first branch 11 and the second branch 12; this method is also applicable in other embodiments described below.

[0102] Embodiment Two

[0103] like Figure 2 As shown, the basic flow path structure and connection relationship of the device for quantitative liquid processing are as follows.

[0104] Container P is used to contain the liquid to be extracted, and container P is open to the atmosphere. A flow path 10 extends outward from the inside of container P (preferably upward) and extends to a branch point a. At this branch point a, the flow path 10 splits into a first branch 11 and a second branch 12. The first branch 11 extends from the branch point a to a first port K1, and the second branch 12 extends from the branch point a to a second port K2.

[0105] like Figure 2 As shown, no components are connected in series in the flow path 10, a first peristaltic pump B1 is connected in series in the first branch 11, and a second shut-off valve F2 is connected in series in the second branch 12.

[0106] Figure 2 The working process of the illustrated embodiment is as follows.

[0107] First, keep the second stop valve F2 closed, then make the first peristaltic pump B1 clockwise rotation (in the orientation shown in the figure as the basis, but not as a limitation of the application). At this time, the liquid in the container P under the first peristaltic pump B1 extraction into the flow line 10, through the first peristaltic pump B1, and then through the first port K1 overflow drain.

[0108] Then, the first peristaltic pump B1 remains stationary (equivalent to the stop state), open the second stop valve F2. At this time, the air from the second port K2 into the liquid between the bifurcation point a and the container P under the action of gravity back to the container P, and the volume of the tube between the bifurcation point a and the first port k1 liquid constant volume due to the peristaltic pump B1 stop and liquid surface tension and inextensible.

[0109] Subsequently, the first peristaltic pump B1 clockwise rotation, then due to the second port K2 air into the resistance is much smaller than the container P in the conduit when the liquid to overcome the gravity, so the air from the second port K2 into the liquid between the bifurcation point a and the first port k1 volume constant volume of the tube from the first port K1 port to be taken out.

[0110] Through the above description can be known, using the preferred case of the inner diameter of the channel characteristics, combined with gravity, the inextensible and surface tension of the liquid physical effects, can be achieved at a lower cost to the technical solution of the application.

[0111] Embodiment Three

[0112] As shown in the preferred embodiment three, and Figure 3 The main difference between the embodiment two shown in Figure 2 The second stop valve F2 is replaced by the second peristaltic pump B2. Thus, when the second peristaltic pump B2 stationary, can play a stop effect. When the need to take out the liquid between the bifurcation point a and the first port k1 volume constant volume of the tube, can make the first peristaltic pump B1 and the second peristaltic pump B2 in the same direction but different speed, so that the liquid from the first port K1 or the second port K2 to take out.

[0113] Embodiment Four

[0114] As shown in Figure 4 The structure and connection of the device for quantitative treatment of liquid is as follows.

[0115] The container P is used for containing the liquid to be extracted, and the container P is an open container. The throughflow pipe 10 extends from the inside of the container P to the outside of the container P (preferably upward), and extends to the bifurcation point a. At the bifurcation point a, the throughflow pipe 10 is bifurcated into the first branch 11 extending from the bifurcation point a to the first port K1 and the second branch 12 extending from the bifurcation point a to the second port K2.

[0116] As shown in the drawings, the first peristaltic pump B1 is arranged in series in the throughflow pipe 10, no device is arranged in series in the first branch 11, and the second peristaltic pump B2 is arranged in series in the second branch 12. Figure 4

[0117] The working process of the embodiment shown is described as follows. Figure 4 First, the second peristaltic pump B2 is kept stationary, and then the first peristaltic pump B1 is rotated counterclockwise (based on the orientation shown in the drawings, but not as a limitation of the present application). At this time, the liquid in the container P enters the throughflow pipe 10 under the extraction of the first peristaltic pump B1, passes through the first peristaltic pump B1 and the intersection point a, and then overflows through the first port K1.

[0118] Then, the first peristaltic pump B1 is kept stationary (equivalent to the cut-off state), and the second peristaltic pump B2 is rotated counterclockwise. At this time, air enters from the first port K1, so that the volume-determined liquid in the pipe between the bifurcation point a and the first port K1 is taken out from the second port K2. Alternatively, the second peristaltic pump B2 is rotated clockwise, so that air enters from the second port K2, so that the volume-determined liquid in the pipe between the bifurcation point a and the first port K1 is taken out from the first port K1.

[0119] As described above, the stationary cut-off working condition and the bidirectional rotation working condition of the two peristaltic pumps can be used to cut off the predetermined liquid sample from the first port K1 or the second port K2 as needed.

[0120]

[0121] Embodiments Five and Six As shown in the drawings, the structure and connection relationship of the device for quantitatively processing liquid are as follows.

[0122] Figure 5 Figure 6

[0123] The container P is used for containing the liquid to be extracted, and the container P is an open container.

[0124] The throughflow pipe 10 extends from the inside of the container P to the outside of the container P (preferably upward), and extends to the bifurcation point a.

[0125] ​​​At the bifurcation point a, the throughflow conduit 10 is divided into a first branch 11 and a second branch 12, the first branch 11 extending from the bifurcation point a to the first port K1, and the second branch 12 extending from the bifurcation point a to the second port K2. The first branch 11 is a conduit extending obliquely from the bifurcation point a to the first port K1, obliquely upward or obliquely downward. The oblique angle of the oblique conduit relative to the horizontal plane can be selected according to the specific application conditions, such as between 30 degrees and 90 degrees, or preferably about 45 degrees.

[0126] As shown in Figure 5 and Figure 6 , a first peristaltic pump B1 is arranged in series in the throughflow conduit 10, no components are arranged in series in the first branch 11, and a second stop valve F2 is arranged in series in the second branch 12.

[0127] Figure 5 and Figure 6 , the working process of the embodiment shown is described as follows.

[0128] First, keep the second stop valve F2 closed. Then rotate the first peristaltic pump B1 counterclockwise (based on the orientation shown in the figure, but not as a limitation of the present application). At this time, the liquid in the container P enters the throughflow conduit 10 under the extraction of the first peristaltic pump B1, passes through the first peristaltic pump B1 and the bifurcation point a, and then overflows through the first port K1.

[0129] Then, in the working condition shown in Figure 5 , the first peristaltic pump B1 is kept stationary, and the second stop valve F2 is opened. At this time, air enters from the second port K2, and the volume-constant liquid in the section of the pipe between the bifurcation point a and the first port K1 flows out from the first port K1 under the action of gravity. In this case, due to the preferred design of a thin channel, when the first peristaltic pump B1 is kept stationary and the second stop valve F2 is closed, the volume-constant liquid in the section of the pipe between the bifurcation point a and the first port K1 does not flow downward by itself, but flows out by itself under the action of gravity when the second stop valve F2 is opened.

[0130] And in the working condition shown in Figure 6 , the first peristaltic pump B1 is kept stationary, and the second stop valve F2 is opened. At this time, air enters from the first port K1, and the volume-constant liquid in the section of the pipe between the bifurcation point a and the first port K1 flows out from the second port K2 under the action of gravity. Similarly, due to the preferred design of a thin channel, when the first peristaltic pump B1 is kept stationary and the second stop valve F2 is closed, the volume-constant liquid in the section of the pipe between the bifurcation point a and the first port K1 does not flow downward by itself, but flows out by itself under the action of gravity when the second stop valve F2 is opened.

[0131] As described above, by simply utilizing the static shut-off function of the peristaltic pump and the inclined design of the branch, coupled with the use of a narrow channel design in the preferred case, it is possible to conveniently intercept and collect liquid samples of accurate volume using gravity.

[0132] The above embodiments do not exhaust all possible combinations of the technical solutions of this application. For example, in different embodiments, when no flow path device is provided, the branch and flow passage can be formed as a through pipe. In some of the above embodiments, the flow passage 10 can be designed as a through pipe; while in other embodiments, the first branch 11 and / or the second branch can be designed as a through pipe. The working process of embodiments not shown in the accompanying drawings of this application can be naturally referred to in the detailed description of the structure and working process of the above various embodiments.

[0133] In all the above embodiments, container P is a container open to the atmosphere. However, in certain operating conditions where the requirements for highly corrosive reagents, volatile reagents, or water samples are more stringent, container P is designed as a closed container that is not directly open to the atmosphere, such as... Figures 7-10 As shown. This type of closed container can be obtained by first injecting liquid into the container and then sealing it. The closed container is connected to a pressurization device for increasing the gas pressure inside the container, and the flow passage 10 extends outward from the inside of the container P. The following will be combined with... Figures 7-10 This will be described in detail.

[0134] Embodiment Seven

[0135] like Figure 7 As shown, the structure and connection relationship of the device for quantitative liquid processing are as follows.

[0136] Container P is used to hold the liquid to be extracted, and container P is a closed container that is not directly connected to the atmosphere.

[0137] The flow path 10 extends outward from the container P (preferably upward) and extends to a branch point a. At the branch point a, the flow path 10 splits into a first branch 11 and a second branch 12. The first branch 11 extends from the branch point a to a first port K1, and the second branch 12 extends from the branch point a to a second port K2.

[0138] like Figure 7 As shown, a first shut-off valve F1 is connected in series in the flow path 10, a second shut-off valve F2 is connected in series in the first branch 11, and a third peristaltic pump B3 is connected in series in the second branch 12.

[0139] Figure 7 The working process of the illustrated embodiment is as follows.

[0140] First, the first stop valve F1 is opened, and the second stop valve F2 is closed. The third peristaltic pump B3 is rotated clockwise, so that air enters the container P from the second port K2 through the first stop valve F1, and the container P is pressurized. Therefore, the third peristaltic pump B3 functions as a pressurizing device at this time.

[0141] Then, the first stop valve F1 is closed, and the third peristaltic pump B3 is kept stationary (stopped). The first stop valve F1 and the second stop valve F2 are opened, and at this time, the liquid in the container P enters the throughflow line 10 under the action of the internal pressure, and then passes through the first stop valve F1 and the second stop valve F2 to overflow through the first port K1.

[0142] Subsequently, the first stop valve F1 is closed, and the third peristaltic pump B3 is rotated clockwise, so that air enters the second port K2, and pushes the liquid in the volume of the pipe between the bifurcation point a and the first port K1 out of the first port K1. Alternatively, the third peristaltic pump B3 is rotated counterclockwise, so that air enters the first port K1, and pushes the liquid in the volume of the pipe between the bifurcation point a and the first port K1 out of the second port K2.

[0143] Embodiment Eight

[0144] As shown in Figure 8 , the structure and connection relationship of the device for quantitatively processing liquid are as follows.

[0145] The container P is used to contain the liquid to be extracted, and the container P is a closed container not directly communicated with the atmosphere. The pressurizing device is a heater 30 arranged in the container, which is used to heat the air in the container.

[0146] The throughflow line 10 extends from the inside of the container P to the outside of the container P (preferably upward), and extends to the bifurcation point a. At the bifurcation point a, the throughflow line 10 is divided into a first branch 11 and a second branch 12, the first branch 11 extends from the bifurcation point a to the first port K1, and the second branch 12 extends from the bifurcation point a to the second port K2.

[0147] As shown in Figure 8 , the first stop valve F1 is arranged in series in the throughflow line 10, no components are arranged in series in the first branch 11, and the third peristaltic pump B3 is arranged in series in the second branch 12.

[0148] Figure 8 The working process of the embodiment shown in

[0149] First, the first shut-off valve F1 opens, and the third peristaltic pump B3 stops. The heater 30 heats and pressurizes the air inside container P. At this time, the liquid inside container P will enter the flow pipe 10 under the action of internal pressure, and then overflow through the first port K1 after passing through the first shut-off valve F1 and the bifurcation point a.

[0150] Then, the first shut-off valve F1 is closed, and the third peristaltic pump B3 is rotated clockwise. Air then enters from the second port K2, pushing out the liquid at the first port K1, which has a constant volume, from the section of pipe between the bifurcation point a and the first port K1. Alternatively, the third peristaltic pump B3 is rotated counterclockwise, and air then enters from the first port K1, pushing out the liquid at the second port K2, which has a constant volume, from the section of pipe between the bifurcation point a and the first port K1.

[0151] In this embodiment, a cooler is preferably provided. After a predetermined volume of liquid sample is collected, the air inside the container P can be cooled so that the liquid between the bifurcation point a and the port 101 of the flow pipe 10 flows back into the container P, thereby facilitating the next liquid collection operation.

[0152] Embodiments Nine and Ten

[0153] See Figure 9 and Figure 10 The implementation method shown is 9 and Figure 8 The main difference in Embodiment 8 shown is the pressurization device.

[0154] In implementation method ten, such as Figure 10 As shown, the pressurization device includes a fourth peristaltic pump B4, through which the liquid container P is directly connected to the external atmosphere. In embodiment nine, as... Figure 9 As shown, the fourth peristaltic pump B4 can be connected to another auxiliary container P2 (containing the same liquid) that is open to the atmosphere, so as to pressurize the liquid in the auxiliary container P2 into the container P.

[0155] For other procedures of extracting predetermined sections of liquid samples, please refer to Implementation Method 8.

[0156] The above embodiments do not exhaust all possible combinations of the technical solutions of this application. For example, a peristaltic pump may also be connected in series in the flow path 10, and a peristaltic pump or a shut-off valve may be connected in series in the second branch or the first branch. The peristaltic pump works in conjunction with the shut-off valve and the pressurizing device to allow a predetermined volume of liquid sample between the bifurcation point a and the first port K1 to flow out of the first port K1 or the second port K2.

[0157] The above describes the implementation methods of closed containers. Each of the above implementation methods can be selected and applied according to the specific working conditions.

[0158] In addition, as shown in the figure, in a preferred case, the first branch 11 is provided with a liquid detector S at a position adjacent to the first port K1, and the liquid between the bifurcation point a and the first port K1 is the liquid between the bifurcation point a and the liquid detector S. The liquid detector S can be various sensors suitable for determining the presence of liquid, to determine whether there is liquid or the liquid reaches the position where the liquid detector S is located.

[0159] By providing the liquid detector S, the volume capacity can be determined without having to make the liquid flow out of the first port K1. That is, in the embodiment provided with the liquid detector S, a more flexible volume end of the liquid sample from the bifurcation point a to the vicinity of the liquid detector S can be intercepted. At the same time, since there is no overflow of liquid, waste can be prevented. Further preferably, the liquid between the bifurcation point a and the liquid detector S is the liquid from the bifurcation point a to a predetermined offset point based on the liquid detector S, and the distance of the predetermined offset point can be controlled by the algorithm of the flow path liquid inlet (for example, related to the flow rate of the liquid, or whether the liquid contains air bubbles, or the length and volume of the air bubbles), so as to realize error compensation for various uncertain factors (air bubbles, liquid flow rate, pulsating liquid error of peristaltic pump liquid inlet, etc.) when the liquid is introduced, to obtain a more accurate liquid sample of a predetermined volume. It can be understood that in the technical solution of the present application, a liquid detector S can also be provided at a position adjacent to the second port K2 of the second branch 12. It can be understood that the technical features of the liquid detector S can be applied to various basic flow paths in the present application, and are not limited to the embodiments illustrated in the drawings of the present application.

[0160] Preferably, an extension section (not shown) extending downward is provided at the first port K1, preferably vertically downward, to ensure that when the liquid overflows at the outlet, the interference of uncertain factors on the volume quantitative interception is avoided, further improving the accuracy of the constant volume.

[0161] Figures 1A-1E and Figures 2-10 The various embodiments of the basic flow path have been described. According to further preferred embodiments, a single basic flow path can be appropriately arranged and combined to be suitable for working occasions of accommodating multiple containers P of the same or different liquids. The combination device scheme formed by the combination of a single basic flow path will be described in detail below.

[0162] In addition, it can be understood that the above basic flow path has the main advantage over the conventional technology in that the flow path scheme using the fine channel in combination with the peristaltic pump and / or the stop valve can achieve high-precision constant volume and push out, and has high work efficiency, very low cost and flexible combination (series, serial or parallel, parallel).

[0163] III. Combined Flow Path Schemes

[0164] As described above, each basic flow path includes five elements, i.e., the first port K1, the second port K2, the first branch 11, the second branch 12 and the bifurcation point a. According to different working conditions and liquid inlet requirements, the above various types of basic flow paths can be combined in different ways to obtain different combined flow path schemes.

[0165] For convenience of description, the application defines the naming and definition of various access modes of the basic flow paths to the main flow branches. The name is divided into three parts, connected by a "-" sign in the middle, such as "1-K1-B" type. The specific naming and definition are as follows:

[0166] The first part of the name indicates the basic flow path used, such as using the basic flow path of Figures 1A-1E , the first part of the name is "1", such as using the basic flow path of Figure 2 , the first part of the name is "2", and so on. It should be noted that since the basic flow path of FIG. 1 has five variants, but the principle is the same, we use the "1A-basic type" flow path as an example. In the combined flow path, we generally use "1" to name it uniformly, unless otherwise specified.

[0167] The second part of the name identifies the access point of the basic flow path to the main flow branch, such as the first port K1, the second part of the name is "K1"; such as the second port K2, the second part of the name is "K2"; such as the bifurcation point a, the second part of the name is "a". And so on.

[0168] The third part of the name identifies the way in which the basic flow path is combined and accessed to the main flow branch. Different combination ways are defined as follows:

[0169] Type A indicates that each type of basic flow path is independently and in parallel connected to the main flow branch, and is identified as "A", such as shown in Figure 11A and Figure 11B , Figure 11C only one basic flow path is exemplarily shown, but it can be understood that multiple basic flow paths can be connected in parallel;

[0170] P type indicates that each type of combined flow path is independent and parallel to the main flow branch, but a peristaltic pump B needs to be configured on the main flow branch to better drive fluid metering and liquid inlet. The combined flow path is marked as "P", as shown in Figure 12 ;

[0171] B type indicates that the first branch 11 of the same type or different type of basic flow path is combined and shared, and then accessed to the main flow branch through the first port K1 or the second port K2. The combined flow path is marked as "B", as shown in Figures 13A-13D ;

[0172] C type indicates that the second branch 12 of the same type or different type of basic flow path is combined and shared, and then accessed to the main flow branch through the first port K1 or the second port K2. The combined flow path is marked as "C", as shown in Figures 14A-14C ;

[0173] BC type indicates that the first branch 11 of the same type or different type of basic flow path is combined and shared, and the second branch 12 is also combined and shared, and then accessed to the main flow branch through the first port K1 or the second port K2. The combined flow path is marked as "BC", as shown in Figures 15A-15D ;

[0174] H type indicates that the intersection a of each type of basic flow path is combined and shared, and directly accessed to the main flow branch with a peristaltic pump or a stop valve in series; or, one or several first branches or second branches in the basic flow path are directly used as the main flow branch. The combined flow path is marked as "H", as shown in FIG. 16.

[0175] It should be noted that the naming of A, B, C, BC, P, H, etc. is only used to distinguish different forms of flow path schemes, and does not constitute a limitation on the protection scope of the present application. The naming method of the above flow path schemes is also applicable to the flow path schemes shown in other figures of the present application.

[0176] It should be noted that in all types of combined flow paths, the intersection a can be a point or a section of the flow path in physical existence. At the same time, in order to more conveniently and simply display the topology structure of the combined flow path accessing to the main flow branch, the trunk and branch of each figure is divided into three rows for display. It should be noted that these trunks and branches can also be formed by a continuous main flow branch according to needs.

[0177] Next, the structure and connection relationship of each type of combined flow path will be described. For the sake of simplicity, only one or two basic flow paths are schematically shown in the present application, and it should be noted that more basic flow paths can be designed in application. In addition, in the combined flow path scheme, the trunk can be one or more. These variations are within the protection scope of the present application.

[0178] 3.1A Type Combined Flow Path:

[0179] The definition of the A-type combined flow path is that each basic flow path is independent of each other, and is connected to a certain upper dry flow branch through the first port K1 or the second port K2, thereby forming a combined flow path in which liquid can be parallelly fed (or can be used for liquid discharge). One port of the dry flow branch is closed, and the other port is used as a common outlet for feeding liquid of each basic flow path, as shown in Figures 11A-11C

[0180] Figures 11A-11C The partial combined forms using the basic flow paths shown in FIGS. 1 to Figure 6 are listed in Table 1.

[0181] For example, "1-K1-A type" means that the basic flow path in FIG. 1 is connected to the dry flow branch through the first port K1, "1-K2-A type" means that the basic flow path in FIG. 1 is connected to the dry flow branch through the second port K2, "2-K1-A type" means that the basic flow path in FIG. 2 is connected to the dry flow branch through the first port K1, and so on. Figure 2

[0182] For example, as shown in Figures 11A-11C , the first port K1 of the basic flow path shown in Figures 1A-1E , the second port K2 of the basic flow path shown in Figures 1A-1E , and the first port K1 of the basic flow path shown in Figure 2 may be independently connected to the same dry flow branch, respectively; or the first port K1 (or the second port K2) of the basic flow path shown in Figure 3 , the first port K1 of the basic flow path shown in Figure 4 , and the second port K2 of the basic flow path shown in Figure 4 may be connected to the same dry flow branch; or the second port K2 of the basic flow path shown in Figure 6 and the first port or the second port (not shown) of the other basic flow path may be connected to the same dry flow branch. The above basic flow paths can be independently fed according to the aforementioned metering feeding steps.

[0183] Meanwhile, the liquid detector S is installed on the branch pipe connected to the dry flow branch in "1-K1-A type", "2-K1-A type", "3-K1-A type", "3-K2-A type", "4-K1-A type", and "6-K2-A type", which is used for metering positioning or detecting whether the liquid reaches the detection position, so as to ensure that the liquid does not enter the dry flow branch according to the working condition during metering.

[0184] It can be understood that the combined flow path schemes shown in Figures 11A-11C are only Figures 1A-1E and​​Figures 2-6 The scope of protection of the present application covers all the possible combinations of the basic flow path arrangements shown. For example, N basic flow paths can be connected to the same trunk flow path, N being a natural number greater than or equal to 1, and each basic flow path can select its own first port K1 or second port K2 to connect to the same trunk flow path. It can also be understood that the basic flow paths are not limited to the schemes shown in Figures 1 to Figure 6 The basic flow path schemes shown can also be selected Figures 7-10 The basic flow path schemes shown can also be selected

[0185] It can be understood that, as mentioned above, although the preferred mode of the present application emphasizes the use of thin channels, this does not mean that other non-thin channel devices that can be combined into various complex channel combinations in the present application are excluded. Without affecting the purpose of achieving the present application, non-thin channels can also be used, at least in part, to use larger diameter pipelines, such as Figure 11C As shown, when a regular volume of more than, for example, 2 milliliters needs to be fixed, the first branch 11 of the "6-K2-A type" can use a coarse fixed volume tube to increase the liquid inlet or outlet speed, thereby improving the overall processing or detection speed of the device.

[0186] The beneficial effect of the A-type combined flow path is that the water samples or reagents connected by each basic flow path can be simultaneously and concurrently in liquid metering, which can greatly improve the overall processing efficiency or detection speed of the device.

[0187] 3.2P Type Combined Flow Path

[0188] Preferably, in order to more conveniently realize the flow of liquid, at least one peristaltic pump B can be provided on the trunk flow path of the A-type combined flow path, as shown. This type of combined flow path is named "P-type combined flow path" by the present application Figure 12

[0189] Figure 12 Two combined flow paths of "5-K2-P type" and "6-K2-P type" are listed. Due to the peristaltic pump B on the trunk flow path, the fluid in the basic flow path can not only flow by gravity or other pump driving, but also better control the movement of the liquid by using the peristaltic pump B on the trunk flow path. It can be understood that Figure 12 This is only an exemplary representation, and other basic flow paths with different numbers can also be selected, and each basic flow path can select its own first port K1 or second port K2 to connect to the same trunk flow path. At this time, the peristaltic pump B in the P-type trunk flow path needs to work with the peristaltic pump and the stop valve in each basic flow path to better transport the liquid in the flow path according to the set requirements.

[0190] 3.3B Type Combined Flow Path: ​

[0191] The definition of a Type B combined flow path is as follows: The first branches 11 of the same basic flow paths are merged and shared, and then connected to a higher-level main branch through either the shared first port K1 or a separate second port K2 (K2'), thus forming a combined flow path that can be used for parallel liquid inflow (and also for liquid outflow). One port of this main branch is closed, and the other port serves as a common outlet for the liquid transported by each Type B combined flow path, such as... Figures 13A-13D As shown.

[0192] Figures 13A-13D The list of uses Figures 1A-1E and Figures 2-6 The various basic flow paths shown are combined and combined according to the above rules, and then connected in parallel to the same main branch through the first port K1 or the second port K2.

[0193] For example, "1-K1-B type" means Figures 1A-1E The basic flow path in the middle has its first branch 11 merged and shared, and then connected to the main branch through the first port K1; "1-K2-B type" refers to Figures 1A-1E The basic flow path in the middle has its first branch 11 merged and shared, and then connected to the main branch through the second port K2; "4-K1-B type" means Figure 4 The basic flow path in the middle has its first branch 11 merged and shared, and then connected to the main branch through the first port K1; "4-K2-B type" refers to Figure 4 The basic flow path in the middle has its first branch 11 merged and shared, and then connected to the main branch through the second port K2; "6-K2-B type" refers to Figure 6 The basic flow path in the middle is shared by its first branch 11, and then connected to the main branch through the second port K2; and so on.

[0194] Each of the above basic flow paths can be fed liquid according to its aforementioned metering and feeding principle and steps. However, when one of the flow paths is working, except for the devices on the first branch 11 that works together, the devices on the other basic flow paths should be in a stationary state (peristaltic pump stationary, shut-off valve closed). This will not be elaborated further here.

[0195] In a preferred embodiment, each type B combined flow path may be equipped with a liquid detector S on the branch pipe connected to the main flow branch for metering positioning or to detect whether the liquid has reached the detection position, so as to ensure that the liquid does not enter the main flow branch during metering according to the working conditions (in some cases, the main flow branch can also be regarded as the extension of the first branch or the second branch (applicable to all embodiments of this application)).

[0196] Understandably, in Figures 13A-13DThe combination flow path scheme shown in the figure is only an embodiment of the basic flow path shown in the figure combined in the form of B-type combination flow path. It can be understood that the application is not limited thereto, and the protection scope of the application covers all permutations and combinations of various basic flow paths. For example, the basic flow paths used to realize the combination flow path are not limited to Figures 1A-1E and Figures 2-6 the basic flow path scheme shown in the figure. The basic flow path scheme shown in Figures 7-10 may also be selected. The basic flow path scheme not shown in the figure may also be selected.

[0197] Compared with the A-type and P-type combination flow paths, the B-type combination flow path has the beneficial effect of reducing the number of peristaltic pumps or stop valves, and accordingly saving cost and improving stability.

[0198] 3.4C Type Combined Flow Path:

[0199] The definition of the C-type combination flow path is that the second branch 12 of the same type of basic flow path is merged and shared, and then accessed to a certain upper dry flow branch through a separately independent first port K1 (K1') or a shared second port K2, thereby forming a combination flow path that can be separately accessed (also can be used for liquid discharge). One port of the dry flow branch is closed, and the other port is used as a common outlet for transporting liquid of each C-type combination flow path, as shown in Figures 14A-14C .

[0200] Figures 14A-14C The combination forms of each basic flow path shown in Figures 1A-1E and Figures 2-6 combined according to the above rules and then connected in parallel to the same dry flow branch through the first port K1 or the second port K2 are listed in the table.

[0201] For example, "1-K1-C type" means that the basic flow path in FIG. 1 is merged and shared at the second branch 12, and then accessed to the dry flow branch through the first port K1; "1-K2-C type" means that the basic flow path in Figure 1A is merged and shared at the second branch 12, and then accessed to the dry flow branch through the second port K2; "4-K2-C type" means that the basic flow path in Figure 4 is merged and shared at the second branch 12, and then accessed to the dry flow branch through the first port K2; and so on.

[0202] Each of the above basic flow paths can be accessed according to the aforementioned metering liquid access principle and steps. However, when one of the through-flow pipes is working, in addition to the devices on the first branch 11 that work together, the devices on the other basic flow paths should be in a static state (peristaltic pump is static, stop valve is closed). This will not be repeated here.

[0203] Meanwhile, each C-type combined flow path can be provided with a liquid detector S on a branch pipe communicating with the dry flow branch, for metering positioning, or detecting whether the liquid reaches the detection position, to ensure that the liquid does not enter the dry flow branch during metering according to the working condition.

[0204] It can be understood that the combined flow path scheme shown in Figures 14A-14C is only a part of the most practical and feasible combined flow path formed by combining the basic flow paths shown in Figures 1A-1E and Figures 2-6 in all permutations and combinations. For example, the basic flow paths used to realize the combined flow path are not limited to the basic flow path schemes shown in Figures 1A-1E and Figures 2-6 , but can also select the basic flow path scheme shown in Figures 7-10 , and can also select the basic flow path scheme not shown in the figure.

[0205] It should be noted that the "1-K1-C type" combined flow path has two or more access points: K1 and K1', which can be different positions of the same dry flow branch (as shown in Figures 14A-14C ), or can be distributed to different dry flow branches (not shown).

[0206] Compared with the A-type and P-type combined flow paths, the C-type combined flow path has the beneficial effect of reducing the number of peristaltic pumps or stop valves, thereby saving costs and improving stability.

[0207] 3.5BC Type Combined Flow Path:

[0208] The definition of the BC-type combined flow path is that the first branch 11 and the second branch 12 of the same type of basic flow path are respectively merged and shared, and then access a higher level dry flow branch through the merged and shared first port K1 or the merged and shared second port K2, thereby forming a combined flow path that can respectively input liquid (also can be used for liquid discharge). One port of the dry flow branch is closed, and the other port is used as a common outlet for transporting liquid for each BC-type combined flow path, as shown in Figures 15A-15D .

[0209] Figures 15A-15D The combined forms of using each basic flow path shown in Figures 1A-1E and Figures 2-6 to combine and merge according to the above rules, and then connecting in parallel to the same dry flow branch through the first port K1 or the second port K2 are listed in

[0210] For example, "1-K1-BC type" means that Figures 1A-1EOne of the basic flow paths, its first branch 11 and second branch 12 are merged and shared, and then connected to the main branch through the first port K1; "1-K2-BC type" refers to the basic flow path in Figure 1, where its first branch 11 and second branch 12 are merged and shared, and then connected to the main branch through the second port K2; "4-K1-BC type" means Figure 4 In the basic flow path, the first branch 11 and the second branch 12 are merged and shared, and then connected to the main branch through the first port K1; "4-K2-BC type" refers to Figure 4 In the basic flow path, the first branch 11 and the second branch 12 are merged and shared, and then connected to the main branch through the second port K2; "6-K2-BC type" refers to Figure 6 The basic flow path in the middle, its first branch 11 and second branch 12 are merged and shared, and then connected to the main branch through the second port K2; and so on.

[0211] in, Figures 15A-15C The combined flow path shown is a combination of two different types of variants of the "1-basic type". The devices connected in series in the flow pipeline are a peristaltic pump and a shut-off valve, and their shut-off effect is the same.

[0212] Each of the above-mentioned basic flow paths can be fed liquid according to its aforementioned metering and feeding principle and steps. However, when one of the flow paths is working, except for the devices on the first branch 11 that works together, the devices on the other basic flow paths should be in a stationary state (peristaltic pump stationary, shut-off valve closed). This will not be elaborated further here.

[0213] Meanwhile, each BC-type combined flow path can be equipped with a liquid detector S on the branch pipe connected to the main flow branch for metering positioning or to detect whether the liquid has reached the detection position, ensuring that the liquid will not enter the main flow branch according to the working conditions during metering.

[0214] Understandably, in Figures 15A-15D The combined flow path scheme shown is only one Figures 1A-1E and Figures 2-6 The implementation shown is based on a combination of BC-type combined flow paths, and the scope of protection of this application covers all its permutations and combinations. It is also understood that, for example, the basic flow paths used to implement the combined flow paths are not limited to... Figures 1A-1E and Figures 2-6 The basic flow path scheme shown can also be selected Figures 7-10 The basic flow path scheme shown can also be selected if it is not shown in the diagram.

[0215] Compared with the A-type, P-type, B-type and C-type combined flow paths, the BC-type combined flow path has the beneficial effect of more effectively reducing the number of peristaltic pumps or stop valves, and accordingly saving cost and improving stability.

[0216] 3.5H Type Combined Flow Path:

[0217] The H-type combined flow path is defined as follows: the intersection point a of each type of basic flow path is merged and shared, and is directly connected to a dry flow branch, which has a peristaltic pump or a stop valve connected in series; or, one or several first branches or second branches in the basic flow path are directly used as dry flow branches. In the H-type combined flow path, a peristaltic pump or a stop valve is connected in series on the through flow branch, the first branch 11 and the second branch 12 of all the basic flow paths, and at least one peristaltic pump must be present. Among all the first branches 11 and the second branches 12 described above, part of the first branches 11 or the second branches 12 are used as constant-volume metering conduits, and the other first branches 11 or second branches 12 or the aforementioned dry flow branches can be used as liquid outlets, as shown in FIG. 16. Through the above combination rules, multiple combined flow paths that can flexibly combine liquid (and can also be used for liquid discharge) can be formed.

[0218] Figure 16A Two H-type combined flow paths are shown, both of which use the basic flow path of FIG. 1 and share the intersection point a, and the difference lies in that the left flow path has a peristaltic pump connected in series on the dry flow branch, and the right flow path has a stop valve connected in series on the dry flow branch.

[0219] Figure 16B A more complex H-type combined flow path is shown, in which each branch above the three through flow branches can be used as a constant-volume metering conduit or a liquid output outlet.

[0220] Each of the above basic flow paths can be filled according to the aforementioned metering liquid principle and steps, except that when one through flow conduit is working, the devices on the first branch 11 or the second branch that work together should be in a static state (peristaltic pump is static, stop valve is closed). This will not be repeated here.

[0221] Compared with the A-type, P-type, B-type, C-type and BC-type combined flow paths, the greatest advantage of the H-type combined flow path is flexibility in combination, and the least number of devices can be used to meter the liquid according to different specifications and then deliver it to different ports (for example, multiple reactors / dishes) for subsequent processing.

[0222] The above describes in detail various combination schemes of the basic flow path of the present application. In operation, the liquid in each container can be intercepted in predetermined volume segments, which can be performed simultaneously or selectively on one or several containers. The liquid is finally pushed out from the selected ports in sequence or simultaneously. Therefore, the above various combination schemes of the basic flow path can separately and individually intercept the liquid in multiple different containers in high precision, simultaneously or in a predetermined order, and deliver the high-precision intercepted liquid. Moreover, due to the combination of the basic flow path, the use of components can be greatly reduced, thereby reducing the overall cost.

[0223] In addition, as described above, Figures 11A-11C and Figures 12-16A and Figure 16B Various types of combination flow path schemes based on the basic flow path are exemplarily shown, and the basic flow path used to realize the combination flow path is not limited to Figures 1A-1E and Figures 2-6 The basic flow path scheme shown in Figures 7-10 The basic flow path scheme shown in

[0224] In addition, it should be noted that the above various liquid inlets and / or liquid outlets in the various combination flow paths can be realized according to various types of liquid inlets and / or liquid outlets of the basic flow path, and therefore these variations are within the scope of the present application.

[0225] IV. Application Flow Path Schemes

[0226] In the application flow path scheme, a (reaction) vessel 100 is included, which is used for reaction processing and / or detection analysis and has a top opening at the top and / or a bottom opening at the bottom. Alternatively, no openings can be provided, and the basic flow path and / or the combination flow path can be allowed to enter the reaction vessel 100 through the top, middle and / or bottom.

[0227] To inject a predetermined liquid sample (with an accurate volume) into vessel 100 for reaction processing and / or analysis, the aforementioned basic flow path scheme and / or combined flow path scheme can be connected to vessel 100. Depending on the application conditions, the connection can be made at the bottom opening, or at both the bottom and top openings, or at the bottom opening and the middle of vessel 100. In other words, the bottom, top, or middle of vessel 100 can all serve as connection points. Preferably, a peristaltic pump or shut-off valve is connected to the bottom opening of vessel 100 to maintain the reaction liquid within vessel 100 or to drain the liquid after the reaction is complete.

[0228] like Figure 17 As shown, the apparatus (application flow path) for quantitative liquid processing has a vessel 100 for reaction processing and / or detection analysis, and has a top opening at the top. This top opening is simultaneously connected to various basic flow paths or various combined flow paths (or suitable combinations thereof). Each container of the various basic flow paths or various combined flow paths can be used to hold different liquids, such as distilled water, water samples to be tested, standard liquids, shielding agents, color developers, cleaning solutions, etc. A peristaltic pump or shut-off valve is connected to the bottom of the reactor / vessel 100, preferably a peristaltic pump that can be driven in both directions (for downward liquid discharge and upward agitation of the liquid, respectively).

[0229] like Figure 18 As shown, the device for quantitative liquid processing (application flow path) has a vessel 100 for reaction processing and / or detection analysis, and has a top opening at the top and a bottom opening at the bottom. The top and bottom openings simultaneously connect to various basic flow paths or various combined flow paths (or suitable combinations thereof). Each container of the various basic flow paths or various combined flow paths can be used to hold different liquids, such as distilled water, water samples to be tested, standard liquids, shielding agents, colorimetric agents, cleaning solutions, etc.

[0230] like Figure 19 and Figure 20As shown, the application flow path of the device for quantitative liquid treatment has a vessel 100 for reaction treatment and / or detection analysis, and has a top opening at the top and a bottom opening at the bottom. The bottom opening is connected to various basic flow paths or various combined flow paths (or suitable combinations thereof). Alternatively, the reactor / vessel 100 is not provided with an opening, and the at least one combined flow path is connected to the reactor / vessel at the top and bottom of the reactor / vessel. Each container of the various basic flow paths or various combined flow paths can be used to contain different liquids, such as distilled water, water sample to be detected, standard liquid, shielding agent, color developing agent, cleaning liquid, etc. When the bottom opening is connected to a basic flow path or a combined flow path, a waste liquid container (not shown) can be used to contain waste liquid, and a cleaning liquid can also be contained, so that the cleaning liquid can be introduced into the vessel 100 to facilitate the cleaning operation of the vessel 100.

[0231] As shown in FIG. 1, Figure 20 Preferably, a basic reaction flow path is formed around one reactor / vessel 100. Multiple basic reaction flow paths can be connected at the bottom to share one or more liquid discharge outlets, so that multiple reactors / vessels 100 can work simultaneously to greatly improve work efficiency. Figure 23 As shown in FIG. 1,

[0232] Under the guidance of the connection mode of the above basic flow path or combined flow path to the reactor / vessel 100, various application flow path combination schemes of the device for quantitative liquid treatment can be formed.

[0233] As shown in FIG. 1, Figures 21-23 are exemplary embodiments of connecting the basic flow path or combined flow path scheme to the top opening of the reactor / vessel 100. In this embodiment, different types of liquids (such as water sample, shielding agent, color developing agent, etc.) can be introduced into the vessel 100 from above relatively independently, so as to avoid cross contamination of the water sample and reagents.

[0234] Figure 21 The left side of the flow path uses a "1-K1-BC" type combined flow path to meter the distilled water and water sample, which enters from the top of the reactor / vessel 100. At the same time, the right side uses a "4-K1-B" type combined flow path to enter from the top of the reactor / vessel 100, and the bottom of the reactor / vessel 100 is connected to a peristaltic pump or a stop valve, preferably a forward and reverse driveable peristaltic pump (which can be used for downward liquid discharge and upward liquid blowing and stirring, respectively). The advantage of this design is that the principle is simple, the structure is simple, the metering accuracy is high, the liquid metering of the water sample and reagents can be performed simultaneously, the time is saved, and the water sample and reagents do not interfere with each other when entering, and there is no cross contamination.

[0235] Figure 22 The flow path is in Figure 21 The flow path is replaced with a "4-K1-BC" combined flow path on the basis of Figure 24 The bottom of the reactor / dish 100 is connected to a peristaltic pump or a stop valve. At the same time, two flow lines are connected at node b, respectively for discharging waste liquid and metering clean liquid. The design also has a liquid detector Sb in series with the pipeline at the bottom of the reactor / dish 100, which can realize the dilution operation of the liquid in cooperation with the peristaltic pump below.

[0236] The specific operation process is as follows: first, the water sample is introduced into the reactor / dish 100, then the liquid is discharged by the peristaltic pump Bb1 until the last liquid just passes through the liquid detector Sb, at which time the liquid discharge is stopped, and the peristaltic pump Bb1 or the peristaltic pump Bb2 is reversed to return the intercepted fixed volume of liquid into the reactor / dish 100, then the peristaltic pump Bbn starts to introduce distilled water, the volume of the introduced liquid can be determined by the liquid detector Sb in cooperation with the liquid introduction time of the peristaltic pump Bbn, finally the peristaltic pump Bb1 or the peristaltic pump Bb2 is reversed to blow all the dilution liquid above the node b into the reactor / dish 100, completing the dilution of the original water sample. Compared with Figure 21 , the design has the advantages of simple structure, convenient operation and low cost. Figure 22 A flow path topology and dilution method for diluting water samples based on the flow path construction idea of the present application are described.

[0237] Figure 23 The left side of the flow path adopts a "1A-basic type" basic flow path to meter the liquid into the reactor / dish 100 from the top of the reactor / dish 100, and the right side uses two "4-basic type" basic flow paths to introduce liquid from the top of the reactor / dish 100, and the bottom of the reactor / dish 100 is connected to a peristaltic pump or a stop valve, preferably a peristaltic pump that can be driven in both directions (which can be used to discharge liquid downward and blow gas upward to stir the liquid, respectively). Compared with Figure 21 Compared with the flow path, the design has the advantages of complete separation of the two reagents on the right side and elimination of any possibility of cross contamination.

[0238] As Figures 24-27As shown, all configurations connect the basic or combined flow path to the bottom opening of the reactor / vessel 100. In this embodiment, different types of liquids (such as water samples, shielding agents, color developers, etc.) can be introduced into the vessel 100 relatively independently from below, and waste liquid can be received and cleaned. The advantages of this design are: devices with the same function, such as peristaltic pumps, shut-off valves, and liquid detectors, on different combined branches can be used together. For example, pumps for draining or blowing, distilled water pumps for cleaning, liquid detectors for detecting liquids, etc., can simplify the flow path and save costs. In addition, the method of entering and draining liquids from the bottom of the reactor / vessel 100 is also very beneficial for cleaning each pipeline, resulting in high cleaning efficiency, saving cleaning water, and reducing the number of air vents and exhaust ports.

[0239] like Figure 24 The flow path shown is to Figure 22 The “4-K1-BC” type combined flow path with liquid inlet on the left side of the top of the flow path reactor / vessel 100 and the “4-K1-B” type combined flow path with liquid inlet on the right side are moved to the bottom of the reactor / vessel 100 for liquid inlet.

[0240] Figure 25 This paper presents a flow path that allows for a simpler liquid inlet function without reducing the amount of water sample and reagents. The flow path consists of a "4-K1-BC type" combined flow path connected to the reactor / vessel. Points b to a form a shared first branch, used as the output port for water samples or reagents. The branch connected to the series peristaltic pump Bd at point d is a shared second branch, used for draining liquid or pumping air into the main flow path to push the metered liquid into the reactor / vessel 100. The multiple branches containing peristaltic pumps Bc, Brn, Br1, and Bb form flow passages. Different metering principles and liquid inlet procedures of this combined flow path are discussed below. Figure 4 Basic flow path and Figure 15B The BC-type combined flow path has been explained in the introduction.

[0241] In all application flow paths of this application, the constant volume during liquid inlet can be achieved by controlling the speed and time of each inlet peristaltic pump, or by controlling the positioning of the liquid section head at a certain position near the liquid detector S. Figure 25 ), for example in Figure 25 , Figure 26 In the process, the liquid detector S between node a and node b can be used to accurately determine the volume of the liquid, or to provide an early warning judgment as to whether the liquid has passed through the point when the instrument is running.

[0242] exist Figure 26In order to more accurately complete the liquid metering and constant volume, the liquid from point f to point a and above can also be emptied into the waste liquid tank through the waste liquid branch by using the series peristaltic pump Bf connected at point f. At this time, the right end position of the liquid accurate constant volume is positioned by the position of the physical node f. Figure 26 The connection structure is shown.

[0243] In order to more flexibly utilize the physical space volume between the nodes on the dry flow branch to perform the constant volume operation on the liquid to be intercepted, the designer can add some air or liquid connected branches on the dry flow branch, so as to high-precision intercept different micro-liquid volume. Figure 27 An example is shown, in which the designer adds a new branch connected with air or used for flushing water discharge between the reagent branch and the distilled water branch at point e, so as to avoid the cross contamination between the reagent and the water sample (standard solution and distilled water) as much as possible.

[0244] In order to completely avoid the cross contamination between the reagent and the water sample (standard solution and distilled water), while the water sample and the reagent can be simultaneously and concurrently fed. Figure 28 An example of moving the outlets of all reagents to the top of the reactor / dish 100 for liquid feeding is shown.

[0245] Next, the basic principles and processes of the flow path metering, liquid feeding, stirring, liquid discharging and dilution are described by taking Figure 27 as an example. It should be noted that Figures 25-28 the corresponding principles and processes of other flow paths are similar, and therefore the working processes of the similar application flow paths are not described in detail.

[0246] Figure 27 The metering process of high-precision liquid feeding is as follows: if water sample needs to be fed, the peristaltic pump Bb is first rotated counterclockwise, the water sample passes through the liquid detector S, stops after a certain volume is flushed, then the peristaltic pump Bb is static, the peristaltic pump Bf is clockwise rotated for a while, and the excess liquid outside point f is sucked into the waste liquid discharge port. Thus, the high-precision liquid feeding of a micro-liquid volume (such as 0.05-2 milliliters) is completed. Of course, the colorimetric detector G in the reactor / dish 100 can also be used to complete the constant volume metering (when the liquid level reaches the horizontal line of the optical axis of point G, the device detects the signal, thereby completing the positioning metering). Then, the peristaltic pumps Bb and Bf are static, and the peristaltic pumps Bg or Be are counterclockwise rotated, so as to send the liquid between points b and f into the reactor / dish 100. The other liquids and reagents in the flow path can be metered and fed in this way. By selecting different water section head (referred to as "water head") cutoff points and air blowing pushing points, the designer can obtain different volumes of micro-liquid feeding. According to the operation, the determined volume of different liquids in different containers can be pushed into the dish 100 in a predetermined order, and then the reaction and / or analysis can be performed in the dish 100.

[0247] The peristaltic pump Bg or Be or Bf rotates counterclockwise, and can blow air into the reactor / dish 100 to stir the liquid. The three pumps can also be used as the outlet for liquid discharge.

[0248] Figure 27 The flow path realizes the dilution operation of the liquid in the reactor / dish 100 as follows: first, the peristaltic pump Bg or Be is started to discharge liquid, and before the water tail passes point f, the peristaltic pump is stopped, then the peristaltic pump Bf is rotated clockwise to discharge the excess liquid to be diluted outside point f, then the peristaltic pump Bg or Be is rotated counterclockwise again to send the intercepted liquid into the reactor / dish 100; finally, the aforementioned metering liquid feeding mode is used, and the micro-liquid or large-volume liquid feeding mode is used to feed distilled water into the reactor / dish 100, and after air blowing and stirring, the mixture is uniformly mixed.

[0249] In Figures 22-28 the combined flow path at the bottom or top of the reactor / dish 100, at least one peristaltic pump is in communication with the atmosphere, and preferably, the peristaltic pump in communication with the atmosphere is farthest from the dish 100 on the common pipeline. Therefore, the peristaltic pump can realize accurate feeding of all reagent containers or reagent dishes on the common pipeline into the reactor / dish 100.

[0250] Preferably, as shown in Figures 22-28 , a liquid detector S is arranged at a position adjacent to the bottom opening of the common pipeline, so that a liquid sample of a volume determined between each branch point and the liquid detector S can be intercepted, thereby obtaining a liquid sample of a more accurate volume. The position of the liquid detector S can be at any position between the intersection point b and the bottom a of the reactor / dish 100. The advantages of the liquid detector S can be seen in the detailed description above.

[0251] In addition, in all application flow paths, the arrangement order of each container P relative to the dish 100 can be selectively designed according to the working procedure. For example, since air is needed to push various reaction liquids, the peristaltic pump in direct communication with the atmosphere needs to be farthest from the dish 100 compared with the peristaltic pump in series in the pipeline of other containers.

[0252] From the above description, it is obvious that in the embodiment shown in Figures 25-28 , the combination of the basic flow path has achieved a high degree of dynamic integration. As shown in Figure 26 , the reaction flow path further comprises a waste liquid container Pf, which is a container in communication with the atmosphere and has a waste liquid pipeline extending from the inside of the waste liquid container Pf to the outside of the waste liquid container Pf, and a peristaltic pump Bf is arranged in series in the waste liquid pipeline, and preferably, the peristaltic pump in the waste liquid pipeline is connected to the portion between the point b and the bottom opening a (in Figure 26At the bifurcation point f), the liquid detector (S) is located near the bifurcation point f. For example... Figure 26 As shown, the leftmost peristaltic pump is directly connected to the atmosphere, allowing air to be introduced into the common pipeline. Meanwhile, the waste liquid container Pf and its peristaltic pump Bf are dedicated to receiving waste liquid, thus avoiding interference with the introduction of air; moreover, because the waste liquid container Pf is close to the vessel 100, it allows for localized drainage, improving efficiency and preventing waste liquid contamination. The characteristics of the waste liquid container Pf can also be applied to other suitable application flow paths.

[0253] exist Figure 27 Figure 27 In the illustrated embodiment, an air / rinsing water outlet container is also added for dilution. The dilution method in the flow path of this application is flexible; besides the aforementioned dilution scheme, different operations can also be used to achieve the dilution function. Specifically, for the liquid to be diluted in container 100, firstly, with other peristaltic pumps stationary, the peristaltic pump of the air / rinsing water outlet container is rotated to draw the liquid to be diluted into the air / rinsing water outlet container. At this time, the liquid to be diluted fills the space between the air / rinsing water outlet and the bottom opening a. Then, the other peristaltic pumps are turned off, and only the peristaltic pump of the waste liquid container is rotated, thereby discharging the liquid to be diluted between the intersection f and the bottom opening a into the waste liquid. At this time, the liquid to be diluted fills the space between the air / rinsing water outlet and f. Then, the other peristaltic pumps are turned off, and only the leftmost peristaltic pump is operated, using air to push the liquid to be diluted between the intersection e and f into container 100. Distilled water is then drawn into container 100, thereby completing the dilution process of the liquid to be diluted.

[0254] FIG. 29 Shown in FIGS. 26-28 Based on the previous design, a "4-K2-BC type" combined flow path was adopted to replace the original separate inlet branches for water sample, standard solution, and distilled water. Since the first branch from c1 to Kc is shared, the inlet volumes of water sample, standard solution, and distilled water are consistent, and cross-contamination with reagents is less likely. If a larger volume of liquid needs to be measured, the c1-Kc conduit for volume determination can be replaced with a branch consisting of a thicker tube connected in series in the middle. The thicker tube must open upwards and its outlet must be higher than the bifurcation point c1 to ensure that liquid does not flow out of the outlet of the thicker tube.

[0255] FIG. 30 It is FIG. 29The combined flow path for the water sample, standard solution, and distilled water inlet has been moved to the end of the main flow path (the far left end relative to reactor / plate 100). This configuration allows the Kc port to be used directly as an air port and a drain outlet for flushing water, while placing the water sample, standard solution, and distilled water at the far left end facilitates the metering of larger volumes of water sample, standard solution, and distilled water. The adjustment of the position of this similar basic or combined flow path on the main flow path can take many forms, not limited to the specific form shown in the figure; all these variations are within the scope of this application.

[0256] FIG. 31 and FIG. 32 They are respectively to FIG. 29 and FIG. 30 The "4-K2-BC type" combined flow path of the main branch has been replaced with another flow path, and the new flow path type of the main branch is "1-K1-P type". Its liquid inlet method and process can be found in the foregoing description of this application.

[0257] FIGS. 25-32 The characteristic of the application flow path is that the first branch 11 and / or the second branch 12 that are matched with each inlet and outlet liquid port are combined and shared, so that the number of devices (peristaltic pump, shut-off valve or liquid detector) used in the application flow path is reduced as much as possible, thereby simplifying the flow path and reducing costs.

[0258] exist FIGS. 25-32 In the application flow path, because a common volumetric branch tube is used, all reagents can only be made to volume sequentially in the common volumetric branch tube before being sent to reactor / plate 100. To accelerate the metering and liquid injection speed, this application also proposes several concurrent metering application flow paths that enable rapid analysis.

[0259] The following is combined with FIGS. 33-35 The application flow provided in this application is described in detail.

[0260] like FIGS. 33-35 The embodiment shown in this application, the flow path for water treatment or detection, includes:

[0261] At least one common pipeline GL1, GL2, on which multiple devices for metering liquid are connected in parallel, wherein at least one device for metering liquid includes:

[0262] Containers Pb, Pc, Pd, Pr1, ..., Prn, which are used to hold the liquid to be extracted;

[0263] A flow passage 10 extends from the inside of the container outward to the bifurcation points b1, c1, r2, ..., r2n. The flow passage 10 is connected in series with peristaltic pumps Bb2, Bc2, Bd2, Br2, ..., Br2n.

[0264] a second branch 12, which is in communication with the through-flow conduit 10 and extends from the branching points b1, c1, r2,..., r2n to second ports b, c, d, r1,..., rn, the second branch 12 is provided in series with a peristaltic pump Bb1, Bc1, Bd1, Br1,..., Brn, and the second ports are all in communication with the common conduit GL1, GL2; and

[0265] a first branch 11, which is in communication with the through-flow conduit 10 and extends from the branching points b1, c1, d1, r2,..., r2n to first ports Kb, Kc, Kd, which are open to the atmosphere.

[0266] Preferably, the first branch and / or the second branch are all fine channels, which have an inner diameter of 0.05mm to 5mm, preferably 0.1mm to 3mm, and more preferably 0.2mm to 2mm. Preferably, at least a part of the common conduit is a fine channel. Preferably, the through-flow conduit is also a fine channel; or the through-flow conduit is a fine channel within a predetermined length range from the branching points b1, c1, r2,..., r2n to the containers Pb, Pc, Pd, Pr1,..., Prn, and the predetermined length range is at least 0.01mm.

[0267] As shown in the application flow path, FIGS. 33-35 different types of combined flow paths can be selected, including but not limited to: 4-K2-BC type and / or 4-K2-A type, so as to integrate or share at least one common conduit GL1, GL2. Preferably, the application flow path includes a reactor / dish 100, and the common conduits are all in communication with the reactor / dish 100. The opening of the common conduit is located at the bottom, middle or upper part of the reactor / dish 100. As a variant, the common conduit drips liquid into the reactor / dish 100 through the opening above the top of the reactor / dish 100, as shown in FIG. 34 The liquid in the container is distilled water, cleaning liquid, water sample to be tested, standard solution or reagent. The reactor / dish 100 is provided with a detector G for detecting the liquid level or liquid capacity inside the reactor / dish 100, and the detector G is a dielectric sensor, pressure sensor or optical sensor.

[0268] As shown in FIG. 33 , FIG. 35 According to one embodiment, the common conduit includes one common conduit GL1, and the opening of the common conduit GL1 is located at the bottom of the reactor / dish 100.

[0269] However, the present application is not limited thereto, and according to another embodiment as shown in FIG. 34In the embodiment shown, the common line also comprises a further common line GL2, to which the plurality of devices for dosing the liquid are connected in parallel, respectively, one common line GL1 and the further common line GL2, which is connected to and / or opens into the interior of the reactor / dish 100 or above the opening thereof, the opening of the common line GL1 being located adjacent to the bottom opening of the reactor / dish 100.

[0270] Preferably, as shown in FIG. 33 , FIG. 34 , FIG. 35 indicated, the application flow path for water treatment or detection comprises at least one outer branch WZ1, WZ2, each of the common lines GL1, GL2 being connected to the atmosphere via an outer branch provided with a peristaltic pump Bq in series, for pumping in and / or pumping out air and / or for discharging liquid. For example, the outer branch can comprise a first outer branch WZ1, which connects the common line GL1 to the atmosphere.

[0271] The first outer branch WZ1 can be connected to the common line GL1 at a suitable point, preferably the first outer branch WZ1 being connected to the common line GL1 in a portion thereof located between the end thereof remote from the reactor / dish 100 and the node of the respective second branch communicating with the container containing the reagent. For example, in the portion between the node rn and r1 in FIG. 33 . Alternatively, preferably, the first outer branch WZ1 is connected to the common line GL1 in a portion thereof located between the end thereof remote from the reactor / dish 100 and the node b of the second branch communicating with the container containing the distilled water, for example between b and c as shown in FIG. 33 . Most preferably, as shown in FIG. 33 , the first outer branch WZ1 is connected to the common line GL1, GL2 at the end thereof remote from the reactor / dish 100, so as to serve the discharge of liquid from the respective combined flow path or the delivery of liquid into the reactor / dish 100.

[0272] Preferably, as shown in FIG. 33 and FIG. 34 , the outer branch also comprises a second outer branch WZ2, provided with a peristaltic pump Bf in series and having an air / washing water / waste liquid discharge opening to the atmosphere, for pumping liquid into the reactor / dish 100 or for discharging waste liquid from the reactor / dish 100 or for discharging washing water. The second outer branch WZ2 can be connected to the common branch at a suitable point, preferably the second outer branch WZ2 being connected to the common line GL1 in a portion thereof located between the reactor / dish 100 and the node of the common line GL1 closest to the reactor / dish 100 (for example the node b in FIG. 33 .

[0273] In the embodiment where another common line GL2 is provided, as shown in FIG. 34 , the other common line GL2 is connected to the atmosphere through a third outer branch WZ3 provided with a peristaltic pump Bq in series, so as to realize liquid discharge or inward gas transfer.

[0274] In addition, in order to accurately intercept a predetermined volume of liquid, preferably, the application flow path includes a liquid detector S provided in the common line GL1 between the reactor / dish 100 and the node (such as the node b in FIG. 34 ) between the through line and the common line GL1 closest to the reactor / dish 100.

[0275] Various different types of combined flow paths can be included in the application flow path in FIGS. 33-35 . For example, in FIG. 33 , the respective containers P3, P4, …, Pn of part of the plurality of devices for quantitatively processing liquid are arranged in parallel and each has a common first branch and a second branch through a respective peristaltic pump B3, B4, …, Bn, and the second port of the second branch is connected to the one common line GL1. That is, a "4-K2-BC" type combined flow path is used here.

[0276] For example, in FIG. 35 , the respective containers P3, P4, …, Pn of part of the plurality of devices for quantitatively processing liquid are arranged in parallel and each has a common first branch and a second branch through a respective stop valve F3, F4, …, Fn, and the second port c of the second branch is connected to the one common line GL1. A modified version of the "4-K2-BC" type and a "4-K2-A" type combined flow path are used here. In the manner shown in FIG. 35 , there is also a variant where the application flow path includes a plurality of containers P3, P4, …, Pn connected to the common line GL1 through a selector valve, without using a combined flow path.

[0277] In addition, in the preferred case, as shown in FIG. 35 , the first port of the first branch of part of the plurality of devices for quantitatively processing liquid leads to the container of the device, which contains reagents, thereby achieving the effect of saving reagents.

[0278] The main flow path of the application flow path shown in FIG. 33 above is a "4-K1-BC" type combined flow path, and the application flow path is in FIG. 29Based on this, the flow paths for reagents 1 to n were replaced with a "4-basic type" flow path. The common flow path GL1 from point b to point rn is equivalent to intersection point a in the "4-K1-BC type" combined flow path; the common flow path GL1 from point b to point c is equivalent to the first branch 11 in the "4-K1-BC type" combined flow path; the first external branch WZ1, connected in series with a peristaltic pump Bq, is equivalent to the second branch 12 in the "4-K1-BC type" combined flow path, used for draining liquid or pumping air into the main flow path to push the metered liquid into the reactor / vessel 100. The greatest advantage of this type of flow path is that it allows for concurrent metering and volume determination of water samples and various reagents, followed by rapid sequential liquid injection according to process requirements. Similarly, it allows for simultaneous cleaning of each branch, thus significantly reducing the instrument's total cycle detection time.

[0279] It should be noted that the outlet of the first branch 11 of each of the above-mentioned reagent "4-basic type" flow paths still returns to the reagent bottle container P. This has the advantage that the reagent pumped out by the peristaltic pump returns to the reagent bottle, saving reagent and eliminating the influence of air bubbles that might have been present in the pipes (such as narrow channels). By increasing the rotation time of the peristaltic pump, the stability and high precision of the entire liquid inlet system are ensured. This structural feature and its beneficial effects are applicable to all flow paths submitted in this application.

[0280] The above FIG. 34 This demonstrates another practical application flow path, in which the water sample, standard solution, and distilled water are metered and brought to volume in parallel on their respective first branches via a "4-basic type" flow path, and then connected to the next higher-level main flow path, ultimately connecting to the bottom of reactor / vessel 100. The reagents are connected to the top opening of reactor / vessel 100 in the same manner. The advantage of this flow path is that each liquid is metered and fed in independently, resulting in rapid inflow, especially during dilution, as distilled water for dilution is already prepared. To further reduce the number of components, the peristaltic pumps for the "air / rinse water drain" on the upper and lower main branches of this application flow path can be omitted; air or rinse water can be discharged directly from ports such as Kb / Kc / Kd.

[0281] FIG. 35 This illustrates an application flow path that utilizes a shut-off valve assembly (F3, F4, ..., Fn within the dashed boxes) and a peristaltic pump Bc2, functionally replacing... FIG. 33 The valve assembly connects to multiple branch lines of the peristaltic pump at the lower end of point C1. This shut-off valve assembly can also be replaced by an N-to-1 multi-channel switching valve.

[0282] FIG. 36 It shows a kind of FIG. 33This system expands the application flow path to include multiple detection indicators. In this flow path, reagents for four different detection indicators (COD, ammonia nitrogen, total phosphorus, and total nitrogen) are connected to the main flow path below the reactor / vessel via different nodes h, g, t, and r. The reactor / vessel 100 is shared by all four indicators. The inlet channels for water sample, standard solution, and distilled water connect to the main flow path below the reactor / vessel from point C. The drain and air pumping are driven by peristaltic pumps Bf and Bq, which are also shared. This application flow path can be easily expanded to achieve time-sharing sequential detection of four indicators at low cost by simply adding a few more peristaltic pumps and their controllers.

[0283] FIG. 37 The flow path will FIG. 36 The distilled water branch in the flow path is separated into a "4-basic" flow path structure. During the dilution operation, it can be used to pre-measure and adjust the volume of distilled water for the diluent, which can reduce the preparation time for the dilution operation.

[0284] FIG. 38 and FIG. 39 This is another practical application flow path type. FIG. 38 In the reactor / vessel, the main body connected to the bottom is a "5-K2-P type" (or "6-K2-P type") combined flow path. At each intersection (b, c, d, e, r, rn), a "5-basic type" flow path (or "6-basic type") is connected. There is an "air / rinsing water / waste liquid drain" on the left and right sides of the flow path to achieve rapid liquid inlet and outlet and complete dilution. It should be noted that the peristaltic pump B at the bottom of the reactor / vessel 100 can also be located on the top-connected pipeline.

[0285] FIG. 39 It was applied FIG. 37 The combined approach will FIG. 37 All “4-basic” flow paths and “4-K2-A” type combined flow paths are replaced by “5-basic” (or “6-basic”) flow paths and “5-K2-P” (or “6-K2-P”) combined flow paths, respectively.

[0286] In order to achieve the goal of measuring more indicators (requiring more reagents) or realizing more functions with as few devices as possible, for example, in the analyzers for total phosphorus and total nitrogen, one reagent is the same, and the customer wants an instrument with two functions that can measure both total phosphorus and total nitrogen at the same time. FIGS. 40-42 This provides several flow paths to solve the above problems.

[0287] FIG. 40 Is FIG. 36Based on the above, another reactor / vessel was added in parallel next to the original reactor / vessel 100 via intersection point c. Each of the two reactors / vessels has a shut-off valve Fc / Fw connected in series on its bottom piping. By controlling the opening and closing of shut-off valves Fc and Fw, the reagents for each indicator connected below the main flow path can be controlled to enter the two different reactors / vessels respectively, thus achieving simultaneous detection of two indicators.

[0288] FIG. 41 Is FIG. 39 Based on the above, another reactor / vessel was added in parallel next to the original reactor / vessel 100 via intersection point c. A peristaltic pump Bc / Bw is connected in series on the bottom piping of each of the two reactors / vessels. By controlling the operation of the peristaltic pumps Bc / Bw, the reagents for each indicator connected below the main flow path can be controlled to enter the two different reactors / vessels respectively, thus achieving simultaneous detection of two indicators. Alternatively, the peristaltic pumps can be connected in series on the sealed piping at the top of the reactor / vessel.

[0289] FIG. 42 This demonstrates a practical application flow path based on the H-type combined flow path. This flow path can simultaneously detect two indicators, total phosphorus and total nitrogen, using only a few peristaltic pumps, shut-off valves, liquid detectors, and two reactors / plates. Moreover, the reagent port and the ports for water sample, standard solution, and distilled water used for both indicators can be shared.

[0290] Taking water sample measurement as an example, the specific liquid inlet and outlet process is as follows: Before operation, all shut-off valves and peristaltic pumps on all branches are closed or stationary. First, shut-off valve Fe is opened, and peristaltic pump Be1 rotates counterclockwise, allowing the water sample to overflow and be brought to volume in the e-Ke section. Then, peristaltic pump Be1 is closed, and peristaltic pump Bk rotates counterclockwise, drawing the water sample from the e-Ke section into the reactor / vessel on the left. The same method is then used to send the water sample into the reactor / vessel on the right. Next, using a similar method, various reagents are sequentially brought to volume in pipelines (e.g., narrow channels) r-Kr1 or rn-Krn, and then drawn into the left and right reactors / vessels to begin the reaction and detection. After detection, rotating Bx, Bf, Bk, and B1 clockwise (usually the flow rates of Bx and Bf are greater than those of Bk and B1) will drain the liquid.

[0291] like FIGS. 21-42 These are schematic diagrams of the reaction flow paths according to preferred embodiments of this application. The working process can be selected and applied by combining basic flow path and combined flow path schemes. As shown in the accompanying drawings, the arrows in the figures can be used to provide corresponding explanations or to indicate substitutions for adjacent diagrams. Zigzag lines can represent longer pipes. Additionally, some ports can return to container P to conserve liquid during overflow and avoid contaminating the external environment.

[0292] In addition, it should be explained that, in the description of the working processes of the basic flow paths, the combined flow paths and the application flow paths, the liquid inlet processes and the liquid outlet processes of the various basic flow paths are described in detail, and the liquid inlet processes and the liquid outlet processes of certain embodiments of the various combined flow paths and the application flow paths are described in detail by way of example, but it can be understood by those skilled in the art that, on the basis of the liquid inlet and outlet processes of the basic flow paths, the possible embodiments of the simultaneous performance and / or sequential performance of the liquid inlet and outlet processes of the various basic flow paths can be fully utilized in the combined flow paths and the application flow paths and various modified combined embodiments thereof, and are within the scope of the present application, and are not limited to the embodiments explicitly disclosed in the present application and the accompanying drawings.

[0293] The preferred embodiments of the present application are described in detail above in combination with the accompanying drawings, but the present application is not limited to the specific details of the above-described embodiments, and various simple modifications can be made to the technical solutions of the present application within the scope of the technical concept of the present application, and these simple modifications all belong to the protection scope of the present application (for example FIG. 43 It should be explained that, in the above-described specific embodiments, various specific technical features can be combined in any appropriate manner without contradiction. In order to avoid unnecessary repetition, the various possible combination manners are not described again in the present application. In addition, the various different embodiments of the present application can also be combined in any manner, as long as it does not deviate from the idea of the present application, and it should also be considered as disclosed in the present application.

Claims

1. An application flow path for water treatment or detection, characterized by, The application flow path comprises: at least one common pipeline (GL1, GL2) to which a plurality of devices for quantitatively processing liquid are connected in parallel, wherein at least one device for quantitatively processing liquid comprises: a container (Pb, Pc, Pd, Pr1,..., Prn) for containing liquid to be extracted, the container (P) being a container open to the atmosphere; a through-flow pipeline (10) extending from the inside of the container to a branching point (b1, c1, r2,..., r2n) and provided in series with a peristaltic pump (Bb2, Bc2, Bd2, Br2,..., Br2n); a second branch (12) communicating with the through-flow pipeline (10) and extending from the branching point (b1, c1, r2,..., r2n) to a second port (b, c, d, r1,..., rn) and provided in series with a peristaltic pump (Bb1, Bc1, Bd1, Br1,..., Brn), the second port being communicated to the common pipeline (GL1, GL2); and a first branch (11) communicating with the through-flow pipeline (10) and extending from the branching point (b1, c1, d1, r2,..., r2n) to a first port (Kb, Kc, Kd) open to the atmosphere, the first branch (11) and the second branch (12) being used to intercept a predetermined volume of liquid; the first branch and / or the second branch are each a fine channel with an inner diameter of 0.05 mm to 5 mm; at least a part of the common pipeline is a fine channel; the through-flow pipeline is also a fine channel; or the through-flow pipeline is a fine channel within a predetermined length range from the branching point (b1, c1, r2,..., r2n) to the container (Pb, Pc, Pd, Pr1,..., Prn), the predetermined length range being at least 0.01 mm.

2. The flow path for water treatment or detection according to claim 1, wherein wherein, the inner diameter of the fine channel of the first branch and / or the second branch is 0.1 mm to 3 mm, or 0.2 mm to 2 mm.

3. The flow path for water treatment or detection according to claim 1, wherein The application flow path comprises a reactor / dish (100), and the common pipelines are each communicated to the reactor / dish (100).

4. The flow path for water treatment or detection according to claim 3, wherein the opening of the common pipeline is located at the bottom, middle or upper part of the reactor / dish (100); and / or the common pipeline drops liquid into the reactor / dish through above the top opening of the reactor / dish (100); and / or the liquid in the container is distilled water, cleaning liquid, water sample to be tested, standard solution or reagent.

5. The flow path for water treatment or detection according to claim 3, wherein The common pipeline comprises one common pipeline (GL1) with an opening located at the bottom of the reactor / dish (100).

6. The flow path for water treatment or detection according to claim 1, wherein The application flow path for water treatment or detection comprises at least one outer branch (WZ1, WZ2), and each common pipeline (GL1, GL2) is communicated to the atmosphere through an outer branch provided in series with a peristaltic pump (Bq) for pumping in and / or pumping out air and / or discharging liquid.

7. The flow path for water treatment or detection according to claim 6, wherein The outer branch comprises a first outer branch (WZ1) which is connected to the common pipe (GL1) to the atmosphere, The first outer branch (WZ1) is connected to the portion of the common pipe (GL1) between the end portion away from the reactor / well (100) and the node of the respective second branch which communicates with the container containing the reagent, The first outer branch (WZ1) is connected to the portion of the common pipe (GL1) between the end portion away from the reactor / well (100) and the node of the second branch which communicates with the container containing distilled water, The first outer branch (WZ1) is connected to the end portion of the common pipe (GL1, GL2) away from the reactor / well (100).

8. The flow path for water treatment or detection according to claim 5, wherein The application flow path comprises a liquid detector (S) which is arranged in the portion of the common pipe (GL1) between the reactor / well (100) and the node of the through-flow pipe closest to the reactor / well (100) and the common pipe (GL1).

9. The flow path for water treatment or detection according to claim 7, wherein The outer branch comprises a second outer branch (WZ2) which is provided in series with a peristaltic pump (Bf) and has an air / washing water / waste liquid discharge opening to the atmosphere, The second outer branch (WZ2) is connected to the portion of the common pipe (GL1) between the reactor / well (100) and the node of the through-flow pipe closest to the reactor / well (100) and the common pipe (GL1).

10. The flow path for water treatment or detection according to claim 5, wherein The common pipe further comprises another common pipe (GL2), and the plurality of devices for quantitatively processing liquid are respectively and in parallel connected to the one common pipe (GL1) and the other common pipe (GL2), the other common pipe (GL2) being connected to and / or extending into the interior of the reactor / well (100) or above the opening of the reactor / well (100), and the opening of the common pipe (GL1) is arranged adjacent to the bottom opening of the reactor / well (100).

11. The flow path for water treatment or detection according to claim 10, wherein The other common pipe (GL2) is connected to the atmosphere through a third outer branch (WZ3) provided in series with a peristaltic pump (Bq).

12. The flow path for water treatment or detection according to claim 5, characterized by, The respective containers (P3, P4, …, Pn) of some of the plurality of devices for quantitatively processing liquid are arranged in parallel and each has a common first branch and a second branch through a respective peristaltic pump (B3, B4, …, Bn), and the second port of the second branch is connected to the one common pipe (GL1).

13. The flow path for water treatment or detection according to claim 5, characterized by, The respective containers (P3, P4, …, Pn) of some of the plurality of devices for quantitatively processing liquid are arranged in parallel and each has a common first branch and a second branch through a respective shut-off valve (F3, F4, …, Fn) in series with a peristaltic pump (Bc2), and the second port (c) of the second branch is connected to the one common pipe (GL1).

14. The flow path for water treatment or detection according to claim 5, characterized by, The application flow path comprises a plurality of containers (P3, P4, …, Pn) which are selectively connected to the common pipe (GL1) through a selection valve.

15. The flow path for water treatment or detection according to claim 1, wherein The first port of the first branch of the portion of the plurality of devices for quantitatively processing a liquid opens into a container of the device, the container containing a reagent.

16. The flow path for water treatment or detection according to claim 3, wherein, The reactor / dish (100) is provided with a detector (G) for detecting the liquid level or the liquid volume inside the reactor / dish (100), the detector (G) being a dielectric sensor, a pressure sensor or an optical sensor.

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