Light-driven nanomotor group for tumor photothermal therapy

A motor, nanotechnology, applied in the field of materials

CN114259575AActive Publication Date: 2022-04-01SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2022-04-01

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Abstract

The invention discloses a light-driven nano motor group for photothermal therapy of tumors. The nano motor is a test-tube-shaped gold-copper nano particle, and one end of a hollow gold tube is sealed by a copper rod. The nanomotor shows autonomous propulsive force, the speed of which can increase with the irradiation intensity of near-infrared light. Under near-infrared irradiation, the nano motors are caused to gather into groups at the center of near-infrared irradiation. By adjusting the irradiation time and the power density of the near-infrared light, the size and the response time of the nano-motor cluster can be easily controlled, and by changing the position of the near-infrared irradiation point, the mass center of the cluster can be guided to move, so that the accurate control of the cluster movement is realized. The nano-motor clusters show a good photo-thermal treatment effect under external near-infrared irradiation, and when the nano-motor clusters are used for photo-thermal therapy, a photo-thermal treatment platform is provided, and efficient tumor cell eradication can be achieved.
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Description

technical field

[0001] The invention belongs to the technical field of materials, and in particular relates to a light-driven nanomotor group for photothermal therapy of tumors. Background technique

[0002] Inspired by self-migrating organisms in nature, synthetic micro-nanomotors are designed to convert chemical fuel or external energy into self-propulsion. These miniaturized mobile devices show great potential in the field of biomedicine, including active cargo delivery, biotherapy, biosensing, and even precision surgery, such as a microrobot ("neutrobot") that can actively deliver cargo to malignant glue in the body. Glioma.

[0003] Among these motors, light-driven motor systems have attracted increasing attention due to their high programmability in the optical domain. Chen et al. reported a TiO 2 - Au nanowire motors that can be precisely controlled by ultraviolet light fields and modulate single neuron activity. TiO 2 Precise manipulation of micromotors under li...

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Embodiment Construction

[0060] The conception and technical effects of the present invention will be clearly and completely described below in conjunction with the embodiments, so as to fully understand the purpose, features and effects of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, rather than all of them. Based on the embodiments of the present invention, other embodiments obtained by those skilled in the art without creative efforts belong to The protection scope of the present invention.

[0061] Wherein the preparation of the Au-Cu motor in the present invention and the schematic flow diagram of using cells for tumor cell therapy after adding the motor are shown in figure 1 .

[0062] Materials and methods

[0063] 1. Synthesis of nanomotors

[0064] A test tube-shaped Au-Cu nanomotor is fabricated as follows:

[0065] The polycarbonate film (aperture 400nm) was pretreated, and gold was deposited on one side (thickne...