sample analyser
By rationally arranging the crossbeams and reaction components of the sample analyzer, and utilizing the gas storage tank group and gas pump to establish pressure, the problem of limited internal space in the blood cell analyzer was solved, enabling rapid sampling and distribution, and improving testing speed and safety.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2018-06-28
- Publication Date
- 2026-04-14
AI Technical Summary
The limited internal space of blood cell analyzers increases the difficulty of structural layout, resulting in low testing speed and poor safety and reliability.
The sample analyzer is designed with a reasonable layout, including the arrangement of the beam, sampling components and reaction components. It uses gas storage tank group and gas pump to establish positive and negative pressure, and combines liquid valve group and quantitative pump group to realize the rapid collection and distribution of biological samples.
It improves the testing speed and safety and reliability of the sample analyzer, reduces costs, and reduces the risk of bubble formation.
Smart Images

Figure CN114295815B_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of medical device technology, and in particular to a sample analyzer. Background Technology
[0002] With the increasing demand for diverse analytical functions in hematology analyzers, the number of components required has grown, making the internal space of these analyzers increasingly limited and increasing the complexity of their structural layout. An unreasonable layout can easily lead to low testing speed and poor reliability. Summary of the Invention
[0003] The technical problem to be solved by the present invention is to provide a sample analyzer with a reasonable structural layout.
[0004] To achieve the above objectives, the embodiments of the present invention adopt the following technical solutions:
[0005] A sample analyzer is provided, comprising:
[0006] The housing includes a first side plate and a second side plate disposed opposite to each other, and a third side plate and a fourth side plate connected opposite to each other between the first side plate and the second side plate;
[0007] A first partition is connected between the first side plate and the second side plate, and a first space is formed between the first partition and the fourth side plate;
[0008] A crossbeam is installed on the first partition plate. The crossbeam includes a first end and a second end opposite to each other. The first end is located in the first space, and the second end passes through the first side plate to extend out of the first space.
[0009] The reaction assembly is housed in the first space and located below the crossbeam; and
[0010] A sampling assembly includes a sampler mounted on the crossbeam and movable between a first end and a second end.
[0011] The sample analyzer further includes a second partition, which is connected between the first side plate and the second side plate, and a second space is formed between the second partition and the third side plate.
[0012] Preferably, the first space is larger than the second space.
[0013] The sampling assembly further includes a first liquid valve group, a hydraulic sensor, and a first syringe installed on the second partition. The first liquid valve group is located in the second space, and the first syringe and the hydraulic sensor are located in the second space and below the first liquid valve group.
[0014] The sample analyzer further includes a driving component, which is used to drive the flow path in the sample analyzer and is located in the first space.
[0015] The drive assembly includes a gas storage tank group and an air pump located in the first space. The air pump is connected to the gas storage tank group and is used to establish positive and negative pressure for the gas storage tank group.
[0016] The sample analyzer further includes a pressure detection plate. The distance between the gas storage tank group and the first side plate is greater than the distance between the gas storage tank group and the second side plate. The pressure detection plate is located between the gas storage tank group and the second side plate and is used to detect the pressure of the gas storage tank group.
[0017] The gas storage tank group includes a first gas storage tank and a second gas storage tank. The air pump establishes a first positive pressure in the first gas storage tank and a first negative pressure in the second gas storage tank.
[0018] The gas storage tank group further includes a third gas storage tank and a fourth gas storage tank. The third gas storage tank is connected to the first gas storage tank so that the first positive pressure establishes a second positive pressure in the third gas storage tank. The fourth gas storage tank is connected to the first gas storage tank or the third gas storage tank so that the first positive pressure or the second positive pressure establishes a third positive pressure in the fourth gas storage tank. The third positive pressure is different from the second positive pressure.
[0019] The sample analyzer further includes a fifth gas storage tank, which is located in the first space and below the gas pump. The fifth gas storage tank is connected to the second gas storage tank so that the first negative pressure establishes a second negative pressure in the fifth gas storage tank.
[0020] The sample analyzer also includes a pressure-building pipeline. The first end of the pressure-building pipeline is connected to the outlet of the air pump, and the second end of the pressure-building pipeline is connected to the air storage tank group. When the pipeline extends from the first end to the second end, it first runs downward and then upward.
[0021] The gas storage tank group is equipped with a float, which is used to trigger an alarm when liquid enters the gas storage tank group.
[0022] The sample analyzer also includes a first valve group, which is used to control the pressure build-up action in the gas storage tank group. The first valve group is located in the first space.
[0023] The sample analyzer further includes a liquid storage tank group and a second liquid valve group. The liquid storage tank group is located in the first space and below the gas storage tank group. The second liquid valve group is used to control the filling and adding of liquid to the liquid storage tank group. The second liquid valve group is located between the first partition and the liquid storage tank group.
[0024] The liquid storage tank group includes a first liquid storage tank, a second liquid storage tank, a third syringe, and a first metering pump group. The third syringe is used to fill the first liquid storage tank with liquid. The third syringe is located between the first partition and the first liquid storage tank. The first metering pump group is connected between the second liquid storage tank and the reaction component.
[0025] The liquid storage tank group further includes a second metering pump, which is connected between the first metering pump group and the second liquid storage tank, and is used to provide backup liquid for the reaction components.
[0026] The sample analyzer also includes a hinged plate, which is rotatably connected to the second side plate and located between the first partition and the fourth side plate. The hinged plate is used to install the liquid storage tank assembly.
[0027] The sample analyzer also includes a reagent pool group for storing reagents used in biological sample processing. The reagent pool group is installed on the second partition and located in the second space.
[0028] The reagent pool group includes multiple reagent pools, a first switching valve, a second switching valve, a first pipeline, and a second pipeline. The first switching valve is used to connect to a positive pressure source, and the first pipeline is connected between the multiple reagent pools and the first switching valve. The second switching valve is used to connect to a negative pressure source, and the second pipeline is connected between the multiple reagent pools and the second switching valve.
[0029] The reagent pool group further includes multiple first branches and multiple second branches. The multiple first branches are connected one-to-one between the multiple reagent pools and the first pipeline, and each first branch is equipped with a one-way valve. The multiple second branches are connected one-to-one between the multiple reagent pools and the second pipeline, and each second branch is equipped with a one-way valve.
[0030] The sample analyzer further includes a third liquid valve group and a second quantitative pump group, which are connected between the reagent pool group and the reaction assembly. The third liquid valve group is located in the second space and below the reagent pool group.
[0031] The sample analyzer further includes multiple third pipelines connected between the third liquid valve group and the reaction component. Each third pipeline includes a first part, a connecting part, and a second part connected in sequence. The first part is connected to the third liquid valve group, and the second part is connected to the reaction component. The reaction component is located below the third liquid valve group. A first height difference is formed between the two ends of the first part, and a second height difference is formed between the two ends of the second part. The connecting part is used to prevent air bubbles from entering the first part from the second part.
[0032] The volume of the first part is smaller than the volume of the metering pump in the second metering pump set.
[0033] The sample analyzer further includes a second valve group, which is connected to the liquid storage tank group and the reagent tank group. The second valve group is located in the second space and between the reagent tank group and the first side plate.
[0034] The sample analyzer further includes a reagent connector and a fourth liquid valve assembly. The reagent connector is fixed to the second side plate and is used to input reagents into the reagent pool assembly. The fourth liquid valve assembly is connected between the reagent connector and the reagent pool assembly.
[0035] The sample analyzer also includes an optical coupler detection component, which is connected between the reagent connector and the fourth liquid valve assembly, and is located below the fourth liquid valve assembly.
[0036] The reaction assembly includes a first reaction chamber, a second reaction chamber, a third reaction chamber, and a fourth reaction chamber. The first reaction chamber is used to form a first test solution for detecting hemoglobin count, the second reaction chamber is used to form a second test solution for detecting white blood cell count, the third reaction chamber is used to form a third test solution for detecting white blood cell differential, and the fourth reaction chamber is used to form a fourth test solution for detecting red blood cell count.
[0037] Specifically, in the direction from the second end to the first end of the crossbeam, the first reaction tank, the second reaction tank, the third reaction tank, and the fourth reaction tank are arranged in sequence.
[0038] The reaction assembly further includes a fifth reaction chamber, which is used to form a fifth test solution for detecting reticulocyte counts. The fifth reaction chamber is located between the third reaction chamber and the fourth reaction chamber.
[0039] The second test solution is also used to detect nucleated red blood cell differential and basophil differential.
[0040] The sample analyzer further includes a first liquid valve and a third metering pump. The first liquid valve is connected between the first reaction tank and the third metering pump. Both the first liquid valve and the third metering pump are located in the first space and below the liquid surface of the first reaction tank.
[0041] The sample analyzer further includes a flow chamber and a second syringe. The flow chamber is located in the first space and above the crossbeam, and the second syringe is located inside the outer casing and below the flow chamber.
[0042] The sample analyzer further includes a third partition, which is disposed in the first space and connected between the first partition and the third side plate, and the flow chamber is disposed above the third partition; the sample analyzer also includes an air pump disposed in the first space, which is disposed below the third partition.
[0043] The reaction assembly includes a second reaction chamber, a third reaction chamber, and a fifth reaction chamber. The second reaction chamber is used to form a second test solution for detecting white blood cell count, the third reaction chamber is used to form a third test solution for detecting white blood cell differential, and the fifth reaction chamber is used to form a fifth test solution for detecting reticulocyte count.
[0044] The sample analyzer further includes a fourth pipeline, the flow chamber is connected to the first access point of the fourth pipeline, the second reaction cell is connected to the second access point of the fourth pipeline, the third reaction cell is connected to the third access point of the fourth pipeline, and the fifth reaction cell is connected to the fourth access point of the fourth pipeline. The first access point, the second access point, the third access point, and the fourth access point are arranged sequentially on the fourth pipeline.
[0045] The sample analyzer further includes a pressure cut-off valve group and a third gas valve group for controlling the pressure cut-off valve group. The pressure cut-off valve group is connected between the flow chamber and the reaction assembly, and the third gas valve group is located in the first space and below the reaction assembly.
[0046] The sample analyzer further includes a waste liquid treatment component, which is installed on the second partition and located in the second space. The waste liquid treatment component includes a first waste liquid tank and a second waste liquid tank, a liquid pump and a fifth liquid valve group arranged at intervals. The first waste liquid tank and the liquid pump are located below the fifth liquid valve group, and the second waste liquid tank is located between the fifth liquid valve group and the second side plate.
[0047] The waste liquid treatment assembly further includes a connecting pipe, a second liquid valve, a liquid level sensor, and a delay controller. The connecting pipe connects the second waste liquid tank and the first waste liquid tank. The second liquid valve is located on the connecting pipe. The liquid level sensor is located in the second waste liquid tank and is used to detect the liquid level height in the second waste liquid tank. The delay controller is coupled to the liquid level sensor and the second liquid valve. The delay controller is used to shut off the second liquid valve after a preset time when the liquid level height drops to a preset value, so that part of the connecting pipe contains liquid and part contains gas. Alternatively, the waste liquid treatment assembly further includes a connecting pipe, a second liquid valve, and an optocoupler detection sensor. The connecting pipe connects the second waste liquid tank and the first waste liquid tank. The second liquid valve is located on the connecting pipe. The optocoupler detection sensor is located on the connecting pipe. When the optocoupler detection sensor detects gas in the connecting pipe, the second liquid valve stops working, so that part of the connecting pipe contains liquid and part contains gas. The cover plate is located on the side of the first side plate away from the second side plate, and the cover plate fastens to the first side plate to form a third space, and the dye assembly is located in the third space.
[0048] The dye assembly includes a dye bag assembly, a third metering pump assembly, and a sixth liquid valve assembly, with the third metering pump assembly and the sixth liquid valve assembly located above the dye bag assembly.
[0049] The sample analyzer further includes a cover plate and a preheating assembly. The cover plate is located on the side of the first side plate away from the second side plate. The cover plate fastens to the first side plate to form a third space. The preheating assembly is installed on the first side plate and located within the third space.
[0050] A fourth space is formed between the first partition and the second partition, and the fourth space is used to arrange the circuit wiring of the sample analyzer.
[0051] Preferably, the sample analyzer further includes a fourth partition, the periphery of which is connected to the first side plate, the second side plate, the third side plate and the fourth side plate and is located above the fourth space, the fourth partition being used to support circuit boards and components;
[0052] The fourth partition includes a fixed part and a movable part rotatably connected to the fixed part, the movable part being used to cover or open part of the fourth space.
[0053] Compared with the prior art, the present invention has the following beneficial effects:
[0054] The sample analyzer described in this embodiment of the invention features a sampler that can move between the first and second ends of the crossbeam. The reaction assembly is located below the crossbeam. Therefore, the sampler can collect biological samples from outside the housing and then quickly move along the direction from the second end to the first end to above the reaction assembly, distributing the biological samples to the reaction assembly. This results in a fast sampling and distribution speed. In short, the sample analyzer improves its testing speed through the rational layout of the crossbeam, the sampler, and the reaction assembly, demonstrating a reasonable structural layout. Attached Figure Description
[0055] To more clearly illustrate the technical solution of the present invention, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.
[0056] Figure 1 This is a schematic diagram of the structure of a sample analyzer provided in an embodiment of the present invention.
[0057] Figure 2 yes Figure 1 The diagram shows a schematic block diagram of some components of the sample analyzer.
[0058] Figure 3 yes Figure 1 A partial exploded view of the sample analyzer shown.
[0059] Figure 4 yes Figure 1 The diagram shows a partial structural schematic of the sample analyzer.
[0060] Figure 5 yes Figure 1 The diagram shows another part of the sample analyzer.
[0061] Figure 6 yes Figure 5 A schematic diagram of the structure shown from another perspective.
[0062] Figure 7 yes Figure 1 A schematic diagram of another part of the structure of the sample analyzer shown.
[0063] Figure 8 yes Figure 1 This is a schematic diagram of another part of the sample analyzer.
[0064] Figure 9 yes Figure 1 The diagram shows a further part of the structure of the sample analyzer.
[0065] Figure 10 yes Figure 1 The diagram shows the partial structural connections of the sample analyzer. Figure 1 .
[0066] Figure 11 yes Figure 1 The diagram shows the partial structural connections of the sample analyzer. Figure 2 .
[0067] Figure 12 yes Figure 1 The diagram shows the partial structural connections of the sample analyzer. Figure 3 .
[0068] Figure 13A yes Figure 1 The diagram shows a connection method between the third liquid valve group and the reaction assembly of the sample analyzer shown.
[0069] Figure 13B yes Figure 1 The diagram shows another connection method between the third liquid valve group of the sample analyzer and the reaction assembly.
[0070] Figure 13C yes Figure 1 The diagram shows another connection method between the third liquid valve group of the sample analyzer and the reaction assembly.
[0071] Figure 13D yes Figure 1 The diagram shows another connection method between the third liquid valve group of the sample analyzer and the reaction assembly.
[0072] Figure 13E yes Figure 1 The diagram shows another connection method between the third liquid valve group of the sample analyzer and the reaction assembly.
[0073] Figure 14 yes Figure 1 The diagram shows the partial structural connections of the sample analyzer. Figure 4 .
[0074] Figure 15 yes Figure 1 The diagram shows the partial structural connections of the sample analyzer. Figure 5 .
[0075] Figure 16 yes Figure 1 The diagram shows the partial structural connections of the sample analyzer. Figure 6 . Detailed Implementation
[0076] The embodiments of this application will now be described with reference to the accompanying drawings.
[0077] Please refer to the following: Figures 1 to 8 This invention provides a sample analyzer 100. The sample analyzer 100 can be used to analyze biological samples, such as blood. The sample analyzer 100 further includes a drive component 1, a sampling component 2, a reaction component 3, a detection component 4, a waste liquid treatment component 5, and a controller 6. The drive component 1 drives various flow paths (including gas and liquid paths) in the sample analyzer 100. The sampling component 2 collects and dispenses biological samples. The reaction component 3 processes the biological samples to form a test solution. The detection component 4 detects the test solution to generate detection information. The waste liquid treatment component 5 collects and discharges waste liquid from the sample analyzer 100. The controller 6 controls the workflow of the sample analyzer 100 and processes the detection information to generate analysis results.
[0078] The sample analyzer 100 further includes a housing 71, a first partition 721, and a crossbeam 73. The housing 71 includes a first side plate 711 and a second side plate 712 disposed opposite to each other, and a third side plate 713 and a fourth side plate 714 connected opposite to each other between the first side plate 711 and the second side plate 712. The first partition 721 connects between the first side plate 711 and the second side plate 712. A first space 741 is formed between the first partition 721 and the fourth side plate 714. The crossbeam 73 is mounted on the first partition 721. The crossbeam 73 includes an opposite first end 731 and a second end 732, the first end 731 being located within the first space 741, and the second end 732 extending through the first side plate 711 and out of the first space 741. The crossbeam 73 extends from the first end 731 to the second end 732, that is, from the interior of the housing 71 to the exterior of the housing 71. The reaction assembly 3 is housed in the first space 741 and located below the crossbeam 73. The sampling assembly 2 includes a sampler 21 (e.g., a sampling needle) which is mounted on the crossbeam 73 and is movable between the first end 731 and the second end 732.
[0079] In this embodiment, since the sampler 21 can move between the first end 731 and the second end 732 of the crossbeam 73, and the reaction assembly 3 is located below the crossbeam 73, the sampler 21 can collect biological samples from outside the housing, and then quickly move along the second end 732 towards the first end 731 to above the reaction assembly 3 to distribute the biological samples to the reaction assembly 3. The sampling and distribution speed of the sampler 21 is relatively fast. In short, the sample analyzer 100 improves its testing speed by rationally arranging the positions of the crossbeam 73, the sampler 21, and the reaction assembly 3, and the structural layout of the sample analyzer 100 is reasonable.
[0080] Optionally, the outer casing 71 further includes a top plate 715 and a bottom plate 716 disposed opposite to each other. The first side plate 711, the second side plate 712, the third side plate 713, and the fourth side plate 714 are connected end-to-end between the top plate 715 and the bottom plate 716. The outer casing 71 encloses a relatively enclosed space for arranging most of the structure of the sample analyzer 100. Any two oppositely disposed plates of the outer casing 71 can be arranged approximately parallel, and any two connected plates of the outer casing 71 can be arranged approximately perpendicular. The first partition plate 721 is disposed opposite to the fourth side plate 714.
[0081] Optionally, the sample analyzer 100 further includes a second partition 722. The second partition 722 is connected between the first side plate 711 and the second side plate 712, and a second space 742 is formed between the second partition 722 and the third side plate 713. In this case, the first space 741 and the second space 742 are spaced apart.
[0082] The first space 741 is larger than the second space 742. The components of the sample analyzer 100 can be flexibly arranged within the first space 741 and the second space 742 according to their own volume and their interconnections. For example, larger components can be arranged within the first space 741.
[0083] Please refer to the following: Figures 1 to 9As an optional embodiment, the sampling assembly 2 further includes a first liquid valve group 81, a hydraulic sensor 22, and a first syringe 23 installed on the second partition 722. The first liquid valve group 81 is located in the second space 742, and the first syringe 23 and the hydraulic sensor 22 are located within the second space 742 and below the first liquid valve group 81. The location of the first syringe 23 below the first liquid valve group 81 helps to avoid the generation of air bubbles and facilitates the removal of air bubbles. The hydraulic sensor 22 can be located above the first syringe 23 and below the first liquid valve group 81. The first liquid valve group 81 includes at least two liquid valves. The first liquid valve group 81 is used to coordinate the sampling and dispensing actions of the sampling assembly 2.
[0084] Optionally, the sampling assembly 2 further includes a first metering pump 91, which is located within the second space 742 and below the first liquid valve assembly 81. Positioning the first metering pump 91 below the first liquid valve assembly 81 helps prevent the generation of air bubbles and facilitates their removal. The first metering pump 91 is connected to the sampler 21 and to a diluent reagent container, which can hold a certain amount of diluent. After the sampler 21 draws in a biological sample that has already been diluted once, the diluent in the first metering pump 91 can perform a secondary dilution of the biological sample in the sampler 21. The diluent in the first metering pump 91 can also be used to flush the tubing of the sampling assembly 2. Those skilled in the art will understand that if secondary dilution of the biological sample is not required, the first metering pump 91 is unnecessary.
[0085] Please refer to the following: Figures 1 to 11 As an optional embodiment, the drive component 1 is located within the first space 741. Placing the relatively large drive component 1 within the relatively large first space 741 improves the space utilization of the first space 741 and makes the internal structure of the sample analyzer more rationally arranged.
[0086] The drive assembly 1 of the sample analyzer 100 includes a gas storage tank assembly 11 and an air pump 12 disposed in the first space 741. The air pump 12 is connected to the gas storage tank assembly 11 and is used to establish positive and negative pressure for the gas storage tank assembly 11. The air pump 12 is located below the gas storage tank assembly 11. The gas storage tank assembly 11 and the air pump 12 are part of the drive assembly 1.
[0087] In use, the air pump 12 establishes positive and negative pressures within the air storage tank group 11. The positive and negative pressures are used to: drive the sampling component 2 to collect biological samples; and / or drive the reaction component 3 to process the biological samples to form a test solution; and / or drive the detection component 4 to detect the test solution to form detection information.
[0088] In this embodiment, the sample analyzer 100 uses a small-volume air pump 12 and a gas storage tank assembly 11 as its main power source, reducing the cost of the sample analyzer 100. The sample analyzer 100 features a highly centralized layout of gas and liquid paths, while striving for gas-liquid separation and minimizing the generation of bubbles in components with strict bubble control requirements. Since the gas storage tank assembly 11 is relatively large, it is located in the first space 741 to make more efficient use of the internal space of the sample analyzer 100.
[0089] Optionally, the gas storage tank group 11 is located above the first space 741, that is, the gas storage tank group 11 is located at the top, so as to isolate it as much as possible from the liquid and electrical circuits in the sample analyzer 100, thereby making the sample analyzer 100 safer and more reliable.
[0090] Optionally, the sample analyzer 100 further includes a pressure detection plate 13. The distance between the gas storage tank assembly 11 and the first side plate 711 is greater than the distance between the gas storage tank assembly 11 and the second side plate 712. The pressure detection plate 13 is disposed between the gas storage tank assembly 11 and the second side plate 712, and is used to detect the pressure of the gas storage tank assembly 11. A pressure sensor is provided on the pressure detection plate 13. In this case, the distance between the pressure detection plate 13 and the gas storage tank assembly 11 is very small, and the connecting pipe between them is very short, thereby enabling the pressure detection plate 13 to reflect the pressure changes of the gas tank in real time.
[0091] Optionally, the gas storage tank assembly 11 includes a first gas storage tank 111 and a second gas storage tank 112. The air pump 12 establishes a first positive pressure in the first gas storage tank 111 and a first negative pressure in the second gas storage tank 112. The first positive pressure and the first negative pressure can be used to drive various flow paths (including gas paths and liquid paths) in the sample analyzer 100. Optionally, the air pump 12 is positioned as close as possible to the first gas storage tank 111 and the second gas storage tank 112 to shorten the pipeline between the air pump 12 and the first gas storage tank 111 and the second gas storage tank 112, thereby reducing flow resistance. The first positive pressure can be 120 kPa, and the first negative pressure can be -40 kPa.
[0092] Optionally, the gas storage tank group 11 further includes a third gas storage tank 113 and a fourth gas storage tank 114. The third gas storage tank 113 is connected to the first gas storage tank 111, so that the first positive pressure establishes a second positive pressure within the third gas storage tank 113. The fourth gas storage tank 114 is connected to the first gas storage tank 111, so that the first positive pressure establishes a third positive pressure within the fourth gas storage tank 114, the third positive pressure being different from the second positive pressure. Both the second positive pressure and the third positive pressure are less than the first positive pressure. The second positive pressure and the third positive pressure can be used to drive different flow paths. The pressure build-up processes of the second positive pressure and the third positive pressure can be performed simultaneously or separately. The second positive pressure can be 90 kPa, and the third positive pressure can be 50 kPa. Those skilled in the art will understand that the fourth gas storage tank 114 can also be connected to the third gas storage tank 113, so that the second positive pressure establishes a third positive pressure within the fourth gas storage tank 114.
[0093] Optionally, the sample analyzer 100 further includes a fifth gas storage tank 115. The fifth gas storage tank 115 is located within the first space 741 and below the air pump 12. The fifth gas storage tank 115 is connected to the second gas storage tank 112, allowing the first negative pressure to establish a second negative pressure within the fifth gas storage tank 115. The second negative pressure can be -30 kPa. Since the fifth gas storage tank 115 urgently needs to utilize the second negative pressure as a power source (e.g., for red blood cell detection) and also needs to collect waste liquid (e.g., waste liquid generated from red blood cell detection), the fifth gas storage tank 115 is positioned below the air pump 12. In this case, the fifth gas storage tank 115 is also located below the gas storage tank group 11, thereby achieving gas-liquid isolation.
[0094] Optionally, the sample analyzer 100 further includes a pressure-building pipeline 116. The first end 1161 of the pressure-building pipeline 116 is connected to the outlet of the air pump 12, and the second end 1162 of the pressure-building pipeline 116 is connected to the air storage tank group 11. When the pipeline extends from the first end 1161 to the second end 1162, it runs downwards first and then upwards. Since the compressed air in the air pump 12 may contain condensate, running the pipeline downwards first and then upwards when extending from the first end 1161 to the second end 1162 prevents condensate from flowing back into the air pump 12 when it is not operating, thereby preventing the air pump 12 from malfunctioning. Neither the first air storage tank 111 nor the second air storage tank 112 contains liquid.
[0095] Optionally, the gas storage tank assembly 11 is equipped with a float 117, which is used to trigger an alarm when liquid enters the gas storage tank assembly 11. For example, the first gas storage tank 111, the second gas storage tank 112, and the third gas storage tank 113 are all equipped with the float 117. If liquid enters the first gas storage tank 111, the second gas storage tank 112, and the third gas storage tank 113, the float 117 will float and trigger an alarm, thereby preventing liquid from entering the air pump 12. In other embodiments, the float 117 may also be provided in the fourth gas storage tank 114.
[0096] Optionally, the sample analyzer 100 further includes a first valve assembly 101, which controls the pressure build-up within the gas storage tank assembly 11. The first valve assembly 101 is located within the first space 741. The first valve assembly 101 can be positioned below and as close as possible to the gas storage tank assembly 11, thereby shortening the pipe length and reducing flow resistance and flow loss. The first valve assembly 101 includes at least two valves.
[0097] Please refer to the following: Figures 1 to 10 As an optional embodiment, the sample analyzer 100 further includes a liquid storage tank assembly 20 and a second liquid valve assembly 82. The liquid storage tank assembly 20 is disposed in the first space 741 and located below the gas storage tank assembly 11. The second liquid valve assembly 82 is used to control the filling and adding of liquid to the liquid storage tank assembly 20, and is located between the first partition 721 and the liquid storage tank assembly 20. The second liquid valve assembly 82 can be installed on the first partition 721. The second liquid valve assembly 82 includes at least two liquid valves.
[0098] Optionally, the liquid storage tank group 20 includes a first liquid storage tank 201 and a second liquid storage tank 202, and the sample analyzer 100 further includes a third syringe 203 and a first quantitative pump group 92. The first liquid storage tank 201 stores sheath fluid for optical sheath fluid measurement, and the sheath fluid may be a diluent. The second liquid storage tank 202 stores diluent for other measurements or cleaning. The third syringe 203 is used to fill the first liquid storage tank 201 with liquid. The third syringe 203 is located between the first partition 721 and the first liquid storage tank 201. The third syringe 203 can replenish the first liquid storage tank 201 with liquid while the first liquid storage tank 201 is supplying liquid to other components. The first liquid storage tank 201 is connected to the third gas storage tank 113. The third gas storage tank 113 is connected to the first liquid storage tank 201 to drive the sheath fluid in the first liquid storage tank 201 to flow out (to the flow chamber 41) through the second positive pressure. The first metering pump assembly 92 is connected between the second storage tank 202 and the reaction component 3. The first metering pump assembly 92 can be used to meterly supply the diluent in the second storage tank 202 to the reaction component 3. The first metering pump assembly 92 includes at least two metering pumps.
[0099] Optionally, the storage tank assembly 20 further includes a second metering pump 93. The second metering pump 93 is connected between the first metering pump assembly 92 and the second storage tank 202, and is used to provide backup liquid for the reaction component 3. When the diluent in the second storage tank 202 is sufficient, the second storage tank 202 provides liquid to the reaction component 3; when the diluent in the second storage tank 202 is insufficient, the second metering pump 93 provides backup liquid to the reaction component 3. The second metering pump 93 is located within the first space 741. The second metering pump 93 is located between the two metering pumps of the first metering pump assembly 92.
[0100] Optionally, the sample analyzer 100 further includes a hinged plate 75. The hinged plate 75 is rotatably connected to the second side plate 712 and located between the first partition plate 721 and the fourth side plate 714. The hinged plate 75 is used to mount the liquid storage tank assembly 20. The fifth gas storage tank 115 may also be mounted on the hinged plate 75. The rotatable configuration of the hinged plate 75 allows for more flexible component arrangement within the sample analyzer 100.
[0101] Please refer to the following: Figures 1 to 13DAs an optional embodiment, the sample analyzer 100 further includes a reagent pool group 30 for storing reagents involved in biological sample processing (e.g., dilution, reaction). The reagent pool group 30 is installed in the second partition 722 and located within the second space 742. To facilitate the flow of reagents from the reagent pool group 30 into the reaction assembly 3, the reagent pool group 30 can be positioned above the reaction assembly 3.
[0102] Optionally, the reagent pool group 30 includes multiple reagent pools 301. The sample analyzer 100 further includes a first switching valve 302, a second switching valve 303, a first conduit 304, and a second conduit 305. The first switching valve 302 is used to connect to a positive pressure source (e.g., the fourth gas storage tank 114 that forms the third positive pressure). The first conduit 304 connects the multiple reagent pools 301 to the first switching valve 302. The second switching valve 303 is used to connect to a negative pressure source (e.g., a fifth gas storage tank 115 that forms the second negative pressure). The second conduit 305 connects the multiple reagent pools 301 to the second switching valve 303. In use, the second switch valve 303 is turned on, connecting the plurality of reagent pools 301 to a negative pressure source, and the reagents in the external reagent tank enter the plurality of reagent pools 301 under the action of differential pressure; then the second switch valve 303 is turned off, and the first switch valve 302 is turned on, connecting the plurality of reagent pools 301 to a positive pressure source, and the reagents in the plurality of reagent pools 301 flow into the reaction component 3 to participate in the biological sample processing process under the action of differential pressure.
[0103] In this embodiment, since the multiple liquid storage tank groups 20 share the first switching valve 302 and the second switching valve 303, the cost of the sample analyzer 100 is reduced. Simultaneously, connecting the first switching valve 302 to a positive pressure source and the second switching valve 303 to a negative pressure source reduces the risk of cross-contamination of the sample analyzer 100. Furthermore, to reduce the amount of foam backflow into the second switching valve 303, an isolation chamber 310 can be added between the second switching valve 303 and the second pipeline 305; the isolation chamber 310 acts as a buffer.
[0104] Optionally, the reagent pool group 30 further includes multiple first branches 306 and multiple second branches 307. The multiple first branches 306 are connected one-to-one between the multiple reagent pools 301 and the first pipeline 304, and each first branch 306 is equipped with a one-way valve 308. The multiple second branches 307 are connected one-to-one between the multiple reagent pools 301 and the second pipeline 305, and each second branch 307 is equipped with a one-way valve 308. In this embodiment, since each first branch 306 and each second branch 307 is equipped with a one-way valve 308, the risk of cross-contamination of the sample analyzer 100 can be reduced.
[0105] Optionally, the sample analyzer 100 further includes a third liquid valve assembly 83 and a second metering pump assembly 94. The third liquid valve assembly 83 and the second metering pump assembly 94 are connected between the reagent pool assembly 30 and the reaction assembly 3. The third liquid valve assembly 83 is located in the second space 742 and below the reagent pool assembly 30. The third liquid valve assembly 83 includes at least two liquid valves. The third liquid valve assembly 83 coordinates the process of adding liquid from the reagent pool assembly 30 to the reaction assembly 3. The second metering pump assembly 94 includes at least two metering pumps. The second metering pump assembly 94 quantitatively inputs the reagent from the reagent pool assembly 30 into the reaction assembly 3. The second metering pump 93 may be located in the second space 742 and below the third liquid valve assembly 83.
[0106] Optionally, the sample analyzer 100 further includes multiple third pipelines 831 connected between the third liquid valve assembly 83 and the reaction component 3. Each third pipeline 831 includes a first portion 8311, a connecting portion 8312, and a second portion 8313 connected in sequence. The first portion 8311 is connected to the third liquid valve assembly 83. The second portion 8313 is connected to the reaction component 3, which is located below the third liquid valve assembly 83. A first height difference is formed between the two ends of the first portion 8311, and a second height difference is formed between the two ends of the second portion 8313. The connecting portion 8312 is used to prevent air bubbles from entering the first portion 8311 from the second portion 8313. The volume of the first portion 8311 may be smaller than the volume of the metering pump in the second metering pump assembly 94.
[0107] In this embodiment, since the height difference between the third liquid valve assembly 83 and the reaction component 3 is divided into a first height difference and a second height difference, and the values of the first height difference and the second height difference are both small, the risk of bubble accumulation in the first part 8311 and the second part 8313 can be reduced. Furthermore, the connecting part 8312 can prevent bubbles from entering the first part 8311 from the second part 8313, further reducing the risk of bubble accumulation in the first part 8311. Therefore, the problem of bubble accumulation caused by a single large height difference between the third liquid valve assembly 83 and the reaction component 3 can be avoided, and the bubbles in the third pipeline 831 can be removed as cleanly as possible.
[0108] Optional, such as Figures 13A to 13D As shown, the connection portion 8312 can be a horizontal pipeline, an inclined pipeline, a coiled pipeline, or a one-way valve. The connection portion 8312 is an inclined pipeline (e.g., Figure 13B As shown, the height of the end of the connecting portion 8312 that connects to the first portion 8311 is lower than the height of the end of the connecting portion 8312 that connects to the first portion 8311.
[0109] Optional, such as Figure 13E As shown, the connection part 8312 can also be a two-way valve. When the two-way valve is energized and opened, the third liquid valve group 83 adds liquid to the reaction component 3. When the liquid addition ends, the two-way valve is de-energized and closed, and a small number of bubbles in the liquid pass through the valve and accumulate in the second part 8313. The next time the third liquid valve group 83 adds liquid to the reaction component 3, the bubbles in the second part 8313 are discharged into the reaction component 3. This cycle continues, preventing a large number of bubbles from accumulating in the third pipeline 831.
[0110] Optionally, the first reagent pool, which is furthest from the first switching valve 302 among the plurality of reagent pools 301, stores diluent. Since the diluent has minimal impact on reagents (e.g., hemolysin) in other reagent pools, even if a small amount of diluent flows back into other reagent pools 301, the impact on the measurement is minimal. Furthermore, since some lower-spec models do not have a first reagent pool for storing diluent, placing the first reagent pool at the end facilitates its closure.
[0111] Optionally, the sample analyzer 100 further includes a second valve assembly 102. The second valve assembly 102 connects the liquid reservoir assembly 20 and the reagent reservoir assembly 30, and is located in the second space 742 between the reagent reservoir assembly 30 and the first side plate 711. The second valve assembly 102 includes at least two valves. The second valve assembly 102 can be used to coordinate the flow path operation of the liquid reservoir assembly 20 and the reagent reservoir assembly 30. The second valve assembly 102 can also be used to coordinate the operation of the first metering pump assembly 92 and the second metering pump assembly 94. The second valve assembly 102 can be positioned at a higher location in the second space 742 to meet gas-liquid isolation requirements. The first switching valve 302 and the second switching valve 303 can also be located within the second valve assembly 102.
[0112] Optionally, the sample analyzer 100 further includes a reagent connector 309 and a fourth liquid valve assembly 84. The reagent connector 309 is fixed to the second side plate 712 to facilitate tubing connection and is used to input reagents into the reagent pool assembly 30. The fourth liquid valve assembly 84 is connected between the reagent connector 309 and the reagent pool assembly 30. The fourth liquid valve assembly 84 includes at least two liquid valves. The fourth liquid valve assembly 84 is used to coordinate the injection of reagents into the reagent pool assembly 30.
[0113] Optionally, the sample analyzer 100 further includes an optical coupler detection component 3010. The optical coupler detection component 3010 is connected between the reagent connector 309 and the fourth liquid valve assembly 84, and is located below the fourth liquid valve assembly 84. The optical coupler detection component 3010 is used to detect the presence of air bubbles in the tubing used for reagent transmission.
[0114] Please refer to the following: Figures 1 to 8 As an optional embodiment, the reaction assembly 3 includes a first reaction chamber 31, a second reaction chamber 32, a third reaction chamber 33, and a fourth reaction chamber 34. The first reaction chamber 31 is used to form a first test solution for detecting hemoglobin (HGB) count. The second reaction chamber 32 is used to form a second test solution for detecting white blood cell count. The third reaction chamber 33 is used to form a third test solution for detecting white blood cell (WBC) differential count. The fourth reaction chamber 34 is used to form a fourth test solution for detecting red blood cell (RBC) count.
[0115] Optionally, the detection component 4 further includes a first detector and a second detector. The first detector is disposed in the first reaction cell 31 and is used to detect the first test liquid by photoelectric colorimetry. The second detector is disposed in the fourth reaction cell 34 and is used to detect the fourth test liquid by electrical impedance method.
[0116] Optionally, in the direction from the second end 732 of the crossbeam 73 towards the first end 731, the first reaction cell 31, the second reaction cell 32, the third reaction cell 33, and the fourth reaction cell 34 are arranged sequentially. The second test solution can also be used to detect nucleated red blood cell differential and basophil differential. Since the second test solution is measured the most times, and the second reaction cell 32 preferentially dispenses the biological sample before the third reaction cell 33, the second reaction cell 32 is positioned closer to the second end 732 than the third reaction cell 33.
[0117] Optionally, the reaction assembly 3 further includes a fifth reaction chamber 35, which is used to form a fifth test solution for detecting reticulocyte (Ret) counts. The fifth reaction chamber 35 is located between the third reaction chamber 33 and the fourth reaction chamber 34. Since the fifth reaction chamber 35 is used less frequently, or even not at all, it is positioned closer to the first end 731 than the second reaction chamber 32 and the third reaction chamber 33.
[0118] Optionally, the sample analyzer 100 further includes a first liquid valve 85 and a third metering pump 95. The first liquid valve 85 is connected between the first reaction cell 31 and the third metering pump 95. Both the first liquid valve 85 and the third metering pump 95 are located within the first space 741 and below the liquid surface of the first reaction cell 31. Since the first liquid valve 85 and the third metering pump 95 are located below the liquid surface of the first reaction cell 31, the tubing connecting the first liquid valve 85 and the third metering pump 95 and used to add reagents to the first reaction cell 31 is always under positive pressure, preventing the generation of air bubbles due to tubing permeability. Simultaneously, the first liquid valve 85 and the third metering pump 95 are both located close to the first reaction cell 31, which shortens the length of the tubing, ensuring that the liquid in the tubing is completely renewed after each measurement, thus preventing the accumulation of air bubbles in the tubing.
[0119] Please refer to the following: Figures 1 to 14As an optional embodiment, the sample analyzer 100 further includes a flow chamber 41 and a second syringe 42. The flow chamber 41 and the second syringe 42 are part of the detection assembly 4. The detection assembly 4 also includes a third detector located at the outlet of the flow chamber 41 to detect the test liquid (e.g., the second test liquid and / or the third test liquid and / or the fifth test liquid) using optical detection. The flow chamber 41 is located in the first space 741 and above the crossbeam 73, and the second syringe 42 is located inside the housing 71 and below the flow chamber 41. The second syringe 42 can be used to push the test liquid preparation section into the flow chamber 41 for detection. The location of the second syringe 42 below the flow chamber 41 helps prevent the generation of air bubbles.
[0120] Optionally, the sample analyzer 100 further includes a seventh liquid valve assembly 86. The seventh liquid valve assembly 86 is connected between the flow chamber 41 and the first reservoir 201 for storing sheath fluid. The seventh liquid valve assembly 86 is positioned beside the flow chamber 41 (e.g., below the flow chamber 41) to facilitate connection and make full use of space. The seventh liquid valve assembly 86 includes at least two liquid valves.
[0121] Optionally, the flow chamber 41 is located in the upper region of the first space 741. For example, the flow chamber 41 may be located between the gas storage tank assembly 11 and the first side plate 711.
[0122] Optionally, the sample analyzer 100 further includes a third partition 723. The third partition 723 is disposed in the first space 741 and connects the first partition 721 and the third side plate 713. The flow chamber 41 is disposed above the third partition 723, and the air pump 12 is disposed below the third partition 723. In this case, the flow chamber 41 and the air pump 12 are respectively disposed on the upper and lower sides of the third partition 723, which can reduce interference between them. The third partition 723 is disposed opposite to the top plate 715.
[0123] refer to Figure 14In one embodiment, the reaction assembly 3 includes a second reaction chamber 32, a third reaction chamber 33, and a fifth reaction chamber 35. The second reaction chamber 32 is used to form a second test solution for detecting white blood cell count, the third reaction chamber 33 is used to form a third test solution for detecting white blood cell differential, and the fifth reaction chamber 35 is used to form a fifth test solution for detecting reticulocyte count. The sample analyzer 100 also includes a fourth conduit 411, the flow chamber 41 is connected to a first access point 4111 of the fourth conduit 411, the second reaction chamber 32 is connected to a second access point 4112 of the fourth conduit 411, the third reaction chamber 33 is connected to a third access point 4113 of the fourth conduit 411, and the fifth reaction chamber 35 is connected to a fourth access point 4114 of the fourth conduit 411. The first access point 4111, the second access point 4112, the third access point 4113, and the fourth access point 4114 are arranged sequentially on the fourth conduit 411. Because the second reaction chamber 32 contains a large number of test solutions and the biological samples are distributed earlier, the distance between the second access point 4112 and the first access point 4111 is the smallest. Because the fifth reaction chamber 35 is used infrequently, or even not at all, the distance between the fourth access point 4114 and the first access point 4111 is the largest.
[0124] Optionally, the sample analyzer 100 further includes a pressure-cutoff valve assembly 50 and a third gas valve assembly 87 for controlling the pressure-cutoff valve assembly 50. The pressure-cutoff valve assembly 50 is connected between the flow chamber 41 and the reaction assembly 3. The pressure-cutoff valve assembly 50 is pneumatically driven (e.g., driven by the first positive pressure within the first gas storage tank 111), which reduces the risk of contamination of the test liquid flowing from the reaction assembly 3 to the flow chamber 41. The pressure-cutoff valve assembly 50 is positioned close to the flow chamber 41 to shorten the length of the pipeline connecting the pressure-cutoff valve assembly 50 and the flow chamber 41, reducing the amount of test liquid prepared. The third gas valve assembly 87 is located in the first space 741 and below the reaction assembly 3. Positioning the third gas valve assembly 87 close to the pressure-cutoff valve assembly 50 shortens the length of the gas pipe connecting the third gas valve assembly 87 and the pressure-cutoff valve assembly 50, thereby reducing flow resistance and gas consumption.
[0125] Please refer to the following: Figures 1 to 15In one optional embodiment, the waste liquid treatment component 5 of the sample analyzer 100 is installed on the second partition 722 and located within the second space 742. The waste liquid treatment component 5 includes a first waste liquid tank 51 and a second waste liquid tank 52 spaced apart, a pump 53, and a fifth valve assembly 88. The first waste liquid tank 51 and the pump 53 are located below the fifth valve assembly 88, and the second waste liquid tank 52 is located between the fifth valve assembly 88 and the second side plate 712. A negative pressure environment is formed within the first waste liquid tank 51 for collecting most of the waste liquid from the sample analyzer 100. The second waste liquid tank 52 is connected to the atmosphere for collecting waste liquid discharged under positive pressure (e.g., waste liquid flowing out from the outlet of the flow chamber 41). The second waste liquid tank 52 is connected to the first waste liquid tank 51, the first waste liquid tank 51 is connected to the second waste liquid tank 52, and the pump 53 is connected to the first waste liquid tank 51. Waste liquid in the second waste liquid tank 52 enters the first waste liquid tank 51 and is then discharged outside the machine by the liquid pump 53. The volume of the first waste liquid tank 51 may be larger than the volume of the second waste liquid tank 52. The fifth liquid valve group 88 includes at least two liquid valves for coordinating the collection and discharge of waste liquid by the waste liquid treatment component 5.
[0126] Optional, such as Figure 16 As shown, in another embodiment, the second waste liquid tank 52 can also solve the foam overflow problem without the liquid level sensor 54 and the delay control unit 61. An optocoupler detection sensor 62 can be installed on the connecting pipe 55 between the second waste liquid tank 52 and the first waste liquid tank 51. When the second waste liquid tank 52 is discharging liquid into the first waste liquid tank 51, the optocoupler detection sensor 62 starts to detect. When it detects that the signal in the optocoupler changes from liquid to bubbles, it controls the second liquid valve 89 to stop discharging. At this time, part of the connecting pipe 55 is foam and part is liquid. Part of the foam in the second waste liquid tank is discharged, avoiding the continuous accumulation of foam in the second waste liquid tank 52.
[0127] Optionally, the waste liquid treatment assembly 5 further includes a connecting pipe 55, a second liquid valve 89, a liquid level sensor 54, and a delay controller 61. The connecting pipe 55 connects the second waste liquid tank 52 and the first waste liquid tank 51. The second liquid valve 89 is disposed on the connecting pipe 55. The liquid level sensor 54 is disposed in the second waste liquid tank 52 and is used to detect the liquid level height of the waste liquid in the second waste liquid tank 52. The delay controller 61 is coupled to the liquid level sensor 54 and the second liquid valve 89. The delay controller 61 is used to shut off the second liquid valve 89 after a preset time when the liquid level height drops to a preset value, so that part of the connecting pipe 55 contains liquid and part contains gas. The second liquid valve 89 may be one of the liquid valves in the fifth liquid valve group 88. The second liquid valve 89 may also be a pressure-driven shut-off valve to avoid clogging of the second liquid valve 89 due to excessive impurities in the waste liquid, which could cause the second liquid valve 89 to malfunction. The delay controller 61 may be formed in the controller 6. The connecting pipe 55 (e.g., a hose) between the first waste liquid tank 51 and the second waste liquid tank 52 is relatively long. The preset value is equal to or close to zero.
[0128] In this embodiment, when the first waste liquid tank 51 needs to extract waste liquid from the second waste liquid tank 52, the second liquid valve 89 connects the first waste liquid tank 51 and the second waste liquid tank 52. Under the action of pressure difference, the waste liquid in the second waste liquid tank 52 is extracted into the first waste liquid tank 51. When the liquid level drops to the preset value, the delay control unit controls the second liquid valve 89 to disconnect the second waste liquid tank 52 from the first waste liquid tank 51 after a preset delay, so that the waste liquid in the second waste liquid tank 52 has been drained. However, about half of the liquid in the connecting pipe 55 is not drained (to prevent the first waste liquid tank 51 from being connected to the atmosphere or a positive pressure source through the second waste liquid tank 52), and the other half is foam. This means that each time the first waste liquid tank 51 extracts waste liquid from the second waste liquid tank 52, a portion of the foam in the second waste liquid tank 52 is drained (at least the portion that enters the above-mentioned pipe), thereby avoiding the continuous accumulation of foam in the second waste liquid tank 52 and solving the problem of foam overflow in the second waste liquid tank 52.
[0129] Optionally, the waste liquid treatment assembly 5 further includes another liquid pump for discharging the waste liquid generated from the cleaning swabs into the first waste liquid pool 51.
[0130] Please refer to the following: Figures 1 to 15As an optional embodiment, the sample analyzer 100 further includes a cover plate 76. The cover plate 76 is located on the side of the first side plate 711 away from the second side plate 712, and the cover plate 76 fastens to the first side plate 711 to form a third space 743. The cover plate 76 is rotatably connected to or snap-fitted to the first side plate 711.
[0131] Optionally, the sample analyzer 100 further includes a dye assembly 60, which is located within the third space 743. The dye in the dye assembly 60 can be used in the biological sample processing. Since only a small amount of dye is needed for each measurement and the dye is consumed slowly, there is no need to install a storage tank for storing dye within the sample analyzer 100. By placing the dye assembly 60 in the third space 743, the dye bag in the dye assembly 60 can be quickly and conveniently replaced by rotating or removing the cover plate 76.
[0132] The dye assembly 60 includes a dye bag assembly 601, a third metering pump assembly 96, and a sixth liquid valve assembly 89, with the third metering pump assembly 96 and the sixth liquid valve assembly 89 located above the dye bag assembly 601. The dye bag assembly 601 includes at least two dye bags. The third metering pump assembly 96 includes at least two metering pumps. The sixth liquid valve assembly 89 includes at least one liquid valve. The third metering pump assembly 96 and the sixth liquid valve assembly 89 coordinate the dispensing action of the dye bag assembly 601.
[0133] Optionally, the sample analyzer 100 further includes a preheating assembly 70. The preheating assembly 70 is mounted on the first side plate 711 and located within the third space 743.
[0134] Please refer to the following: Figures 1 to 9 As an optional embodiment, the sample analyzer 100 further includes a sample introduction platform 80. The sample introduction platform 80 is located on the side of the first side plate 711 away from the second side plate 712 and below the crossbeam 73. The sample introduction platform 80 is used to place and transfer test tubes containing biological samples.
[0135] Please refer to the following: Figures 1 to 15 As an optional embodiment, a fourth space 744 is formed between the first partition 721 and the second partition 722. The fourth space 744 is used to arrange the circuit wiring of the sample analyzer 100. Components in the sample analyzer 100 that require electrical drive (such as metering pumps, gas valves, liquid valves, etc.) can be installed on the first partition 721 and the second partition 722.
[0136] Optionally, the sample analyzer 100 further includes a fourth partition 724. The periphery of the fourth partition 724 is connected to the first side plate 711, the second side plate 712, the third side plate 713, and the fourth side plate 714, and is located above the fourth space 744. The fourth partition 724 is used to support circuit boards and components. The fourth partition 724 is disposed opposite to the top plate 715 and between the top plate 715 and the bottom plate 716. The controller 6 may be disposed on the fourth partition 724.
[0137] The fourth partition 724 includes a fixed portion 7241 and a movable portion 7242 rotatably connected to the fixed portion 7241. The movable portion 7242 is used to cover or partially open the fourth space 744. By rotating the movable portion 7242, the fourth space 744 can be quickly partially opened, thereby facilitating the maintenance of wiring and / or components within the fourth space 744.
[0138] The sample analyzer of this embodiment includes components such as a sampling component, a reaction component, a detection component, a waste liquid treatment component, and a drive component, as well as electrical, gas, and liquid pipelines between the components. The liquid circuit is driven by gas, with the power source coming from an air pump located inside the analyzer. Multiple gas storage tanks at different pressures constitute the main power source for the entire analyzer's liquid circuit, ensuring performance requirements while reducing costs. The positional relationship of the components and the design of the electrical, gas, and liquid pipelines between the components in this embodiment of the sample analyzer have a reasonable structural layout, maximizing space utilization. While meeting the design requirements of multi-parameter and high-speed sample analyzers, it is small in size and low in cost.
[0139] The embodiments of the present invention have been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only for the purpose of helping to understand the method and core ideas of the present invention. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the ideas of the present invention. Therefore, the content of this specification should not be construed as a limitation of the present invention.
Claims
1. A sample analyzer, characterized in that, include: Housing and wastewater treatment components installed within the housing; The waste liquid treatment assembly includes a first waste liquid tank, a second waste liquid tank, and a liquid pump; A negative pressure environment is formed in the first waste liquid tank for collecting waste liquid through negative pressure. The second waste liquid tank is connected to the atmosphere and is used to collect waste liquid discharged by positive pressure. The first waste liquid tank is connected downstream of the second waste liquid tank, and the first waste liquid tank is also used to extract waste liquid from the second waste liquid tank; The liquid pump is connected to the outlet of the first waste liquid tank and is used to discharge the waste liquid in the first waste liquid tank; The housing includes a first side plate and a second side plate disposed opposite to each other, and a third side plate and a fourth side plate connected opposite to each other between the first side plate and the second side plate; The sample analyzer also includes a second partition, which is connected between the first side plate and the second side plate, and a second space is formed between the second partition and the third side plate; The waste liquid treatment assembly is installed on the second partition and located within the second space; The sample analyzer also includes: A first partition is connected between the first side plate and the second side plate, and a first space is formed between the first partition and the fourth side plate; A crossbeam is installed on the first partition plate. The crossbeam includes a first end and a second end opposite to each other. The first end is located in the first space, and the second end passes through the first side plate to extend out of the first space. The reaction assembly is housed in the first space and located below the crossbeam; and A sampling assembly includes a sampler mounted on the crossbeam and movable between a first end and a second end.
2. The sample analyzer as described in claim 1, characterized in that, The volume of the first waste liquid tank is larger than the volume of the second waste liquid tank.
3. The sample analyzer as described in claim 1, characterized in that, The waste liquid treatment assembly further includes a connecting pipe, a valve, a level sensor, and a delay controller. The connecting pipe connects the second waste liquid tank and the first waste liquid tank. The valve is located on the connecting pipe. The level sensor is located in the second waste liquid tank and is used to detect the liquid level height in the second waste liquid tank. The delay controller is coupled to the level sensor and the valve. The delay controller is used to shut off the valve after a preset time when the liquid level height drops to a preset value, so that part of the connecting pipe contains liquid and part contains gas.
4. The sample analyzer as described in claim 3, characterized in that, The preset value is equal to zero.
5. The sample analyzer as described in claim 1, characterized in that, The waste liquid treatment assembly also includes a connecting pipe, a valve, and an optocoupler detection sensor. The connecting pipe is connected between the second waste liquid tank and the first waste liquid tank. The valve is installed on the connecting pipe. The optocoupler detection sensor is installed on the connecting pipe. When the optocoupler detection sensor detects gas in the connecting pipe, the valve stops working so that part of the connecting pipe contains liquid and part contains gas.
6. The sample analyzer as described in any one of claims 3 to 5, characterized in that, The valve is a liquid valve or a pressure shut-off valve.
7. The sample analyzer as described in any one of claims 1 to 5, characterized in that, The sample analyzer also includes an air pump, a second air tank, and a fifth air tank installed in the housing. The air pump establishes a first negative pressure in the second air tank, and the fifth air tank is connected to the second air tank so that the first negative pressure establishes a second negative pressure in the fifth air tank. The fifth air tank uses the second negative pressure as a power source to collect waste liquid.
8. The sample analyzer as described in any one of claims 1 to 5, characterized in that, The sample analyzer also includes a flow chamber installed inside the housing, the outlet of which is connected to the second waste liquid tank.
9. The sample analyzer as described in claim 1, characterized in that, The waste liquid treatment assembly also includes a fifth liquid valve group, which includes at least two liquid valves for coordinating the collection and discharge of waste liquid by the waste liquid treatment assembly. The first waste liquid tank and the liquid pump are located below the fifth liquid valve group, and the second waste liquid tank is located between the fifth liquid valve group and the second side plate.
10. The sample analyzer as described in claim 1, characterized in that, The sample analyzer includes a gas storage tank group and a gas pump located in the first space. The gas pump is connected to the gas storage tank group and is used to establish positive and negative pressure for the gas storage tank group.
11. The sample analyzer as described in claim 10, characterized in that, The gas storage tank group includes a second gas storage tank, and the air pump establishes a first negative pressure in the second gas storage tank; The sample analyzer also includes a fifth gas storage tank, which is located in the first space and connected to the second gas storage tank, so that the first negative pressure establishes a second negative pressure in the fifth gas storage tank.
12. The sample analyzer as described in claim 11, characterized in that, The fifth gas storage tank uses the second negative pressure as a power source to collect waste liquid, and the fifth gas storage tank is located below the air pump.
13. The sample analyzer as described in claim 1, characterized in that, The reaction assembly includes a first reaction chamber, a second reaction chamber, a third reaction chamber, and a fourth reaction chamber. The first reaction chamber is used to form a first test solution for detecting hemoglobin count, the second reaction chamber is used to form a second test solution for detecting white blood cell count, the third reaction chamber is used to form a third test solution for detecting white blood cell differential, and the fourth reaction chamber is used to form a fourth test solution for detecting red blood cell count.
14. The sample analyzer as described in claim 13, characterized in that, In the direction from the second end of the crossbeam to the first end, the first reaction tank, the second reaction tank, the third reaction tank, and the fourth reaction tank are arranged in sequence.
15. The sample analyzer as described in claim 1, characterized in that, The sample analyzer also includes a flow chamber and a second syringe. The flow chamber is located in the first space and above the crossbeam, and the second syringe is located inside the housing and below the flow chamber.
16. The sample analyzer as described in claim 15, characterized in that, The sample analyzer further includes a third partition, which is disposed in the first space and connected between the first partition and the third side plate, and the flow chamber is disposed above the third partition; the sample analyzer also includes an air pump disposed in the first space, which is disposed below the third partition.
17. The sample analyzer as described in claim 15, characterized in that, The reaction assembly includes a second reaction chamber, a third reaction chamber, and a fifth reaction chamber. The second reaction chamber is used to form a second test solution for detecting white blood cell count, the third reaction chamber is used to form a third test solution for detecting white blood cell differential, and the fifth reaction chamber is used to form a fifth test solution for detecting reticulocyte count. The sample analyzer further includes a fourth pipeline, the flow chamber is connected to the first access point of the fourth pipeline, the second reaction cell is connected to the second access point of the fourth pipeline, the third reaction cell is connected to the third access point of the fourth pipeline, and the fifth reaction cell is connected to the fourth access point of the fourth pipeline. The first access point, the second access point, the third access point, and the fourth access point are arranged sequentially on the fourth pipeline.
18. The sample analyzer as described in claim 15, characterized in that, The sample analyzer also includes a pressure cut-off valve group and a third gas valve group for controlling the pressure cut-off valve group. The pressure cut-off valve group is connected between the flow chamber and the reaction assembly, and the third gas valve group is located in the first space and below the reaction assembly.
Citation Information
Patent Citations
Particle analyzer of sheath-flow impedance method
CN101173887A
Waste liquid collecting device, waste liquid discharge system and discharge method
CN102370561A
Flow chamber component, flow chamber blockage removing method and sample analyzer
CN102564919A
Three-classification full-automatic blood cell analysis meter
CN201780303U
Blood analyser alarm
CN2814356Y