Implant

Abstract

An implant, comprising a tubular stent structure (1) and a skirt (2), the stent structure (1) being provided with barbed structures (4), the stent structure (1) being radially contractible or radially expandable, the stent structure (1) comprising a circumferentially distributed mesh structure, the skirt (2) being disposed on the surface of the stent structure (1), the mesh structure comprising a first mesh unit (11) and a second mesh unit (12), the area of the first mesh unit (11) being larger than the area of the second mesh unit (12), the size of the second mesh unit (12) being substantially the same as the size of the barbed structures (4), the barbed structures (4) being receivable into the second mesh unit (12). This implant can prevent the barbed structures (4) and the skirt (2) from being entangled and interfering with each other when the stent structure (1) is compressed and expanded during loading and release.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and particularly relates to an implant. Background Art

[0002] The heart is a very important organ of the human body, providing power for the blood circulation of the human body. The heart is divided into left and right parts, each part containing a ventricle and an atrium. The ventricles are separated from each other and the atria are separated from each other by the interventricular septum and the interatrial septum. There are valves between the atria, ventricles and arteries to prevent blood reflux. Among them, the valve between the left atrium and the left ventricle is the mitral valve, the valve between the right atrium and the right ventricle is the tricuspid valve, the valve between the left ventricle and the large artery is the aortic valve, and the valve between the right ventricle and the pulmonary artery is the pulmonary valve.

[0003] The above-mentioned valves open and close correspondingly with the contraction and relaxation of the heart. Therefore, the heart valves must be able to withstand the extrusion of blood and the surrounding valve ring and the scouring of blood for a long time. If the valve cannot be fully closed or opened insufficiently due to disease or other reasons, it will lead to blood reflux and insufficient blood flow supply. For example: valve stenosis leads to poor blood circulation or insufficiency of closure, which will cause insufficient blood supply to the heart, thus greatly increasing the burden on the heart and leading to heart failure. For such heart valve diseases, the traditional treatment method is to open the chest and stop the heart. Under the support of hypothermic cardiopulmonary bypass, the heart is opened for surgical repair of the valve or replacement of the artificial valve. After the operation, the heart is restarted to complete the subsequent operations. Surgical valve replacement has large trauma and long recovery time for patients. Therefore, elderly patients are often contraindicated for surgery due to advanced age, weak constitution, severe lesions or combined with other diseases.

[0004] Minimally invasive surgical techniques are constantly evolving. Among them, artificial heart valves can be introduced into the patient's body through a catheter, that is, the heart valve is placed through a minimally invasive interventional surgery without thoracotomy, so the trauma is small and the postoperative recovery is fast. For those patients with heart valve stenosis who cannot have their lives extended or their pain relieved by current conventional treatment methods, a new solution is provided. However, since this technology has emerged for a relatively short time, there are still many problems at present. For example, the stent of the existing interventional artificial heart valve is still in the initial stage of research, and the types of stents are few. There are defects such as being not conducive to rapid and accurate release, and being prone to displacement under blood flow pressure and scouring after release, and it is still impossible to achieve an ideal interventional treatment effect. To solve the problem of stent positioning, the method of adding barbs can be adopted. After the valve is released, the barbs can penetrate into the blood vessel tissue wall after the heart valve is implanted into a specific position, so that the valve is not easily displaced in the blood vessel. However, when the stent is compressed and expanded during the loading and release processes, the barbs provided on the stent are prone to interference with the skirt. For example, when the stent is loaded, it needs to be compressed into a shape with a smaller diameter. At this time, the skirt structure shrinks into each grid of the stent as the stent is compressed, and the barbs are easily entangled with the skirt. When the diameter of the stent expands during release, the entanglement of the barbs and the skirt makes it difficult to release the stent and easily leads to surgical failure. Since the barbs and the valve stent tube form a certain angle, during the process of loading and releasing the valve in the delivery sheath, the barb structure is prone to scratching the inner wall of the sheath. When the delivery device is implanted into the human body, if the filaments scraped out of the sheath remain in the human body, it will increase the risk of the surgery. Summary of the Invention

[0005] The object of the present invention is to at least avoid the entanglement of barbs and the skirt during the compression and expansion of the implant during the loading and release processes, which affects the release of the implant. This object is achieved in the following ways:

[0006] An implant, comprising a tubular stent structure and a skirt. The stent structure is provided with a barb structure. The stent structure can be radially contracted or radially expanded. The stent structure includes a circumferentially distributed mesh structure. The skirt is arranged on the surface of the stent structure. The mesh structure includes a first mesh unit and a second mesh unit. The area of the first mesh unit is larger than the area of the second mesh unit. The size of the second mesh unit is approximately the same as the size of the barb structure. The barb structure can be received in the second mesh unit.

[0007] In one embodiment, there is a connection between two adjacent first mesh units, and the second mesh unit is arranged at the connection.

[0008] In one embodiment, the first mesh unit is a hexagonal structure, and one side of one hexagonal structure coincides with one side of another hexagonal structure to form the connection.

[0009] In one embodiment, at least one arc-shaped convex structure is provided in the axial direction of the support structure on the first mesh unit, and the arc-shaped convex structure protrudes in a direction away from the first mesh unit.

[0010] In one embodiment, the barbed structure includes a connection end, a first position, and a free end. The connection end is connected to the connection part, the free end can extend out of the second mesh unit, and the first position is located between the connection end and the free end. Wherein, the angle formed by the straight line constituted by the connection end and the first position and the central axis of the support structure is greater than the angle formed by the straight line constituted by the connection end and the free end and the central axis of the support structure.

[0011] In one embodiment, the barbed structure includes a first section and a second section connected to each other. The first section is between the connection end and the first position, the second section is between the first position and the free end, and the free end is a tip structure.

[0012] In one embodiment, the first section is a straight bar structure, and the first surface of the second section facing the outside of the support structure is set as an arc structure.

[0013] In one embodiment, the first section is a straight bar structure or an arc-shaped structure, and the second section is an arc-shaped structure.

[0014] In one embodiment, the barbed structure and the support structure are formed separately and then connected together, or the barbed structure and the support structure are integrally formed by cutting a pipe.

[0015] In one embodiment, the implant is a heart valve, and the heart valve further includes a valve structure. The valve structure includes a plurality of valve leaflets. The plurality of valve leaflets are mutually attached. Each valve leaflet includes a valve angle, and the valve angle passes through the second mesh unit from the inside to the outside of the support structure.

[0016] By providing the second mesh unit capable of accommodating the barbed structure, the area of the second mesh unit is small, and the size of the second mesh unit is substantially the same as the size of the barbed structure, just accommodating the barbed structure. The skirt located in the second mesh unit has a small area and a small degree of shrinkage, so it is not easy to be entangled with the barbed structure, and it is possible to avoid the mutual interference between the barbed structure and the skirt when the support structure compresses and expands during loading and releasing.

[0017] An implant, comprising a tubular support structure and a barbed structure provided on the support structure. The support structure includes a mesh structure distributed circumferentially. The barbed structure can be received into the mesh structure, and the barbed structure includes an elastic element.

[0018] One end of the elastic element is connected to the mesh structure to form a connection end;

[0019] The elastic element is arranged to protrude outward from the support structure to form a first position, and then bend towards the support structure from the first position;

[0020] A window structure is arranged on the elastic element, a barbed structure connected to the window structure is arranged in the window structure, the barbed structure has a free end, the free end extends out of the window structure in a direction away from the support structure, and the angle formed by the straight line constituted by the connection end and the first position and the central axis of the support structure is greater than the angle formed by the straight line constituted by the connection end and the free end and the central axis of the support structure.

[0021] In one embodiment, the connection end is connected to the distal end of the mesh structure, and the barbed structure is connected to the proximal end of the window structure; or, the connection end is connected to the proximal end of the mesh structure, and the barbed structure is connected to the distal end of the window structure.

[0022] In one embodiment, the mesh structure includes a first mesh unit and a second mesh unit, the area of the first mesh unit is larger than the area of the second mesh unit, the size of the second mesh unit is substantially the same as the size of the barbed structure, and the barbed structure can be received in the second mesh unit.

[0023] In one embodiment, there is a connection part between two adjacent first mesh units, and the second mesh unit is arranged at the connection part.

[0024] In one embodiment, the first mesh unit is a hexagonal structure, and one side of one hexagonal structure coincides with one side of another hexagonal structure to form the connection part.

[0025] In one embodiment, the support structure can be radially contracted or radially expanded. As the support structure is radially contracted or radially expanded, the first mesh unit is compressed or expanded circumferentially along the support structure. Among them, at least one arc-shaped convex structure is arranged on the first mesh unit in the axial direction of the support structure, and the arc-shaped convex structure protrudes in a direction away from the first mesh unit.

[0026] In one embodiment, the free end is a tip structure.

[0027] In one embodiment, the barbed structure and the support structure are respectively formed and then connected into one body.

[0028] In one embodiment, the barbed structure and the support structure are integrally formed by cutting a pipe.

[0029] In one embodiment, the implant is a heart valve, and the heart valve further includes a valve structure. The valve structure includes a plurality of valve leaflets. The plurality of valve leaflets are attached to each other. Each valve leaflet includes a valve corner. The valve corner passes through the second mesh unit from the inside to the outside direction of the stent structure and is then sutured to the skirt.

[0030] The above implant can be received into the mesh structure by providing a barbed structure. The barbed structure includes an elastic structure. The elastic structure has a connecting end, a first position, and a window structure. A barbed structure is provided in the window structure. The barbed structure has a free end. The free end extends out of the window structure in a direction away from the stent structure. The angle formed by the straight line connecting the connecting end and the first position and the central axis of the stent structure is greater than the angle formed by the straight line connecting the connecting end and the free end and the central axis of the stent structure. This can ensure that when the connecting end of the elastic structure is pressed by the sheath tube to be flush with the mesh structure, the free end of the barbed structure does not protrude. When the sheath tube releases the implant, only when the sheath tube is released until the connecting end of the barbed structure extends out of the mesh structure, the free end of the barbed structure will be released. Thereby, it is avoided that during the process of loading, releasing or withdrawing, the free end of the barbed structure is likely to scrape out filamentous debris along the inner wall of the sheath tube, and this debris is likely to bring an immune risk when the transporter is implanted into the human body. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] By reading the following detailed description of the preferred embodiments, various other advantages and benefits will become clear to those of ordinary skill in the art. The drawings are only for the purpose of showing the preferred embodiments and are not considered to be a limitation of the present invention. Moreover, throughout the drawings, the same reference numerals are used to represent the same components. Among them:

[0032] Figure 1 Schematic diagram of a heart valve provided by an embodiment of the present invention.

[0033] Figure 2 is Figure 1 Schematic diagram of the stent structure in

[0034] Figure 3 is Figure 1 Schematic diagram of the valve structure in

[0035] Figure 4 is Figure 2 Enlarged view of A in

[0036] Figure 5 Schematic diagram of the structure of the cooperation between the barbed structure and the second mesh unit in another embodiment.

[0037] Figure 6 is Figure 5 Another perspective view of

[0038] Figure 7 Schematic diagram of the cooperation between the barbed structure and the second mesh unit in another embodiment.

[0039] Figure 8 It is Figure 7 schematic diagram of another perspective of

[0040] Figure 9 It is Figure 7 schematic diagram of yet another perspective of Detailed implementation manners

[0041] The exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. Although the exemplary embodiments of the present invention are shown in the drawings, it should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided so that the present invention can be more thoroughly understood and the scope of the present invention can be completely conveyed to those skilled in the art.

[0042] It should be understood that the terms used herein are for the purpose of describing specific example embodiments only and are not intended to be limiting. Unless the context clearly indicates otherwise, the singular forms "a", "an" and "the" as used herein may also include the plural forms. The terms "comprising", "including", "containing" and "having" are inclusive and thus specify the presence of the stated features, steps, operations, elements and / or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and / or combinations thereof. The method steps, processes, and operations described herein are not to be construed as necessarily requiring them to be performed in the particular order described or illustrated, unless the order of execution is explicitly stated. It should also be understood that additional or alternative steps may be used.

[0043] Although the terms first, second, third, etc. may be used herein to describe multiple elements, components, regions, layers and / or sections, these elements, components, regions, layers and / or sections should not be limited by these terms. These terms may only be used to distinguish one element, component, region, layer or section from another. Unless the context clearly indicates otherwise, terms such as "first", "second" and other numerical terms used herein do not imply an order or sequence. Therefore, the first element, component, region, layer or section discussed below may be referred to as the second element, component, region, layer or section without departing from the teachings of the example embodiments.

[0044] For ease of description, spatial relative relationship terms may be used in the text to describe the relationship of one element or feature shown in the figure with respect to another element or feature. These relative relationship terms are, for example, "inner", "outer", "inner side", "outer side", "below", "beneath", "above", "over", etc. Such spatial relative relationship terms are intended to include different orientations of the device during use or operation other than the orientations depicted in the figure. For example, if the device in the figure is flipped, an element described as "below" or "beneath" other elements or features will then be oriented as "above" or "over" other elements or features. Thus, the exemplary term "below" can include both upward and downward orientations. The device may be otherwise oriented (rotated 90 degrees or in other directions) and the spatial relative relationship descriptors used in the text are accordingly interpreted.

[0045] It should be noted that the terms "distal end" and "proximal end" are used as orientation terms, which are common terms in the field of interventional medical devices. The "distal end" refers to the end away from the operator during the surgical procedure, and the "proximal end" refers to the end close to the operator during the surgical procedure. In the embodiments of the present invention, the implant may be a heart valve, a covered stent, a occluder, etc. After the heart valve is implanted into the human body, blood flows into the heart valve from the blood inflow end, passes through the interior of the heart valve, and flows out from the blood outflow end.

[0046] Referring to Figure 1 , an embodiment of the present invention provides a heart valve 100, which includes a stent structure 1, a skirt 2, and a valve structure 3. Among them, the stent structure 1 is in a tubular structure, and the stent structure 1 includes an inflow end 101 and an outflow end 102; the skirt 2 is processed from a flat or cylindrical polyester cloth, and the skirt 2 is arranged on the inner surface or the outer surface of the expanded stent structure 1 by sewing; the valve structure 3 is arranged on the inner surface of the stent structure and is sewn on the skirt 2, and the valve structure 3 includes at least two leaflets 31.

[0047] In Figure 2 , the stent structure 1 includes a circumferentially distributed mesh structure, and the mesh structure includes a first mesh unit 11 and a second mesh unit 12. The area of the first mesh unit 11 is larger than the area of the second mesh unit 12. There is a connection between two adjacent first mesh units 11, and the second mesh unit 12 is arranged at the connection. A barb structure 4 is arranged in the second mesh unit 12. The size of the second mesh unit 12 is substantially the same as the size of the barb structure 4, and the barb structure 4 can be received in the second mesh unit 12.

[0048] The so-called "substantially the same" here means that after the barb structure 4 is received in the second mesh unit 12, there is a certain gap between the barb structure 4 and the second mesh unit 12.

[0049] In this embodiment, the first mesh unit 11 and the second mesh unit 12 are circumferentially distributed at the outflow end 102 of the stent structure 1. In other embodiments, the first mesh unit 11 and the second mesh unit 12 can be arbitrarily distributed at any position of the stent structure 1. Among them, the first mesh unit 11 is a hexagonal structure, and one side of a hexagonal structure coincides with one side of the other hexagonal structure to form a connection part, and the second mesh unit 12 is arranged at this connection part, and the second mesh unit 12 is a rectangular structure. In other embodiments, the shapes of the first mesh unit 11 and the second mesh unit 12 are not limited. For example, the first mesh unit 11 can also be an octagonal structure, and the second mesh unit 12 can also be an oval, square, triangle, etc., as long as the barb structure 4 can be received in the second mesh unit 12. In other embodiments, two adjacent first mesh units 12 are connected by a connecting piece, and the two adjacent first mesh units 12 are independent of each other and do not coincide, and the second mesh unit 12 is arranged on the connecting piece.

[0050] If the second mesh unit 12 is not provided and the barb structure 4 is directly arranged on the first mesh unit 11, the first mesh unit 11 provides an appropriate radial force for the stent structure 1, and the area of the first mesh unit 11 cannot be too small, otherwise the radial force of the stent structure 1 will be too large and it is not easy to be compressed and received in the sheath. And the area of the first mesh unit 11 is large, and the skirt part located in the first mesh unit 11 will be wrinkled together when the stent structure 1 contracts, and it is easy to be wound together with the barb structure 4 arranged on the first mesh unit 11. When the diameter of the stent structure 1 expands during release, the barb structure 4 is wound with the skirt 2, resulting in difficult release of the stent structure 1 and easy failure of the operation. However, in this embodiment, the second mesh unit 12 capable of receiving the barb structure 4 is provided. The area of the second mesh unit 12 is small, and the size of the second mesh unit 12 is roughly the same as the size of the barb structure 4, just enough to accommodate the barb structure 4. Since the area of the skirt located in the second mesh unit 12 is small, the degree of wrinkling is small, so it is not easy to be wound together with the barb structure 4, and it can avoid the mutual interference between the barb structure 4 and the skirt 2 when the stent structure 1 is compressed and expanded during loading and release.

[0051] See Figure 3 , the valve structure 3 includes three valve leaflets 31, each valve leaflet 31 includes valve angles 311 / 312, suture edges 313 and opening edges 314, and the opening edges 314 of the three valve leaflets 31 are mutually attached to form an attachment surface 315. Combine Figure 1 and Figure 3, the suture edge 313 is sutured to the inner wall of the skirt 2; the flap corners 311 / 312 pass through the second mesh unit 12 from the inside to the outside of the stent structure 1 and are then circumferentially sutured to the outer wall of the skirt 2; the fitting surface 315 of the opening edge 314 faces the outflow end 102, so that blood can only flow in from the inflow end 101 and flow out from the outflow end 102, and cannot flow back. It should be noted that, in this embodiment, the second mesh unit 12 can be used to set the barbed structure 4 or to fix the flap corners 311 / 312.

[0052] Among them, at least one arc-shaped convex structure 111 is arranged on the first mesh unit 11 along the axial direction of the stent structure 1, and the arc-shaped convex structure 111 protrudes away from the first mesh unit 11. When the stent structure 1 is radially compressed, due to the existence of the arc-shaped convex structure 111, the first mesh unit 11 is not completely closed and there are gaps, and these gaps can provide more accommodation space for the leaflets 31 near the arc-shaped convex structure 111, thereby reducing the creases of the leaflets 31 when the stent structure 1 is compressed.

[0053] In this embodiment, the mesh structure further includes a third mesh structure 13, and the third mesh structure 13 can be a polygonal structure, such as a rhombus or a hexagon. The third mesh structure 13 is spliced together with the first mesh structure 11 and the second mesh unit 12 and is distributed circumferentially along the stent structure 1, and the splicing form is not limited.

[0054] See Figure 4 , the barbed structure 4 includes a connection end 41, a first position 42 and a free end 43. The connection end 41 is connected to the second mesh unit 12, the free end 43 can extend out of the second mesh unit 12, and the first position 42 is located between the connection end 41 and the free end 43. Among them, the angle formed by the straight line formed by the connection end 41 and the first position 42 and the central axis of the stent structure 1 is greater than the angle formed by the straight line formed by the connection end 41 and the free end 43 and the central axis of the stent structure 1. It should be noted that the angle formed by the straight line formed by the connection end 41 and the first position 42 and the central axis of the stent structure 1 is greater than the angle formed by the straight line formed by the connection end 41 and the free end 43 and the central axis of the stent structure 1, which specifically means that the straight line where the connection end 41 and the first position 42 are located is at a higher position relative to the free end 43. In this way, it can be ensured that when the connection end 41 of the barbed structure 4 is pressed into the second mesh unit 12 and flush with the stent rod by the sheath tube, the free end 43 will not be exposed. When the stent structure 1 is released from the sheath tube, only when it is released to the connection end 41 of the barbed structure 4, the free end 43 will be released. In this way, it can be avoided that during the loading, releasing or withdrawing process, the free end of the barbed structure is prone to scrape out filamentous debris along the inner wall of the sheath tube, and this debris remains in the blood vessel when the transporter is implanted into the human body and enters the human internal circulation, which is prone to bring immune risks.

[0055] In this embodiment, the barb structure 4 further includes a first section 44 and a second section 45 that are connected to each other. Between the connection end 41 and the first position 42 is the first section 44, and between the first position 42 and the free end 43 is the second section 45. The free end 43 is a tip structure, which facilitates the valve to pierce into the blood vessel wall during the positioning process. In other embodiments, the tip structure may not be provided because the barb structure 4 itself is small and easily penetrates into the tissue. Among them, the first section 44 is a straight bar structure, and the first surface 46 of the second section 45 facing the outside of the stent structure is set as an arc structure, which further avoids damaging the inner wall of the sheath tube.

[0056] See Figure 5 and Figure 6 , in another embodiment, the barb structure 4 is integrally in an "S" shape. The first section 44 is an arc-shaped structure, and the second section 45 is also an arc-shaped structure. The free end 43 extends outward from the stent structure 1, and the free end 43 is a tip structure. Among them, the angle formed by the straight line formed by the connection end 41 and the first position 42 and the central axis of the stent structure 1 is greater than the angle formed by the straight line formed by the connection end 41 and the free end 43 and the central axis of the stent structure 1.

[0057] In this embodiment, the stent structure 1 is made of nitinol material. The barb structure 4 and the stent structure 1 are formed separately and then connected together. For example, they can be connected by welding, or the barb structure 4 and the stent structure 1 are integrally formed by cutting a pipe. Among them, the arc-shaped part of the barb structure 4 can be bent by clamping with tweezers and cooperating with hot blowing, and the arc structure on the barb structure 4 can be made by grinding.

[0058] In another embodiment, see Figures 7 - 8 , the barb structure 4 includes an elastic element 47, and the elastic element 47 can be received into the mesh structure. Specifically, the elastic element 47 can be arranged in the first mesh unit 1 or the second mesh unit 12, or any mesh structure on the stent structure 1.

[0059] In this embodiment, one end of the elastic element 47 is connected to the second mesh unit 12 to form the connection end 41; the elastic element 47 is arranged to protrude outward from the stent structure 1 to form the first position 42, and then bends from the first position 42 towards the stent structure 1; a window structure 48 is arranged on the elastic element 47, and a thorn-like structure 431 is arranged in the window structure 48. The thorn-like structure 431 has a free end 43, and the free end 43 extends out of the window structure 48 in a direction away from the stent structure 1. The same as the above embodiment, the angle formed by the straight line formed by the connection end 41 and the first position 42 and the central axis of the stent structure 1 is greater than the angle formed by the straight line formed by the connection end 41 and the free end 43 and the central axis of the stent structure 1.

[0060] In this embodiment, the elastic element 47 is in the opposite direction to the bending direction of the free end 43 of the spiky structure 431. During the release and loading processes of the stent structure 1, only the elastic element 47 is compressed and expanded, and the bending angle of the spiky structure 431 remains unchanged, so that a better piercing direction can be maintained. In this embodiment, the stent structure can be a radially contractible or radially expandable structure, or a radially non-contractible or radially non-expandable structure.

[0061] In addition, the connection end 41 is connected to the distal end (close to the blood outflow end) of the second mesh unit 12, and the spiky structure 431 is connected to the proximal end (close to the blood inflow end) of the window structure 48, or the connection end 41 is connected to the proximal end (close to the blood inflow end) of the second mesh unit 12, and the spiky structure 431 is connected to the distal end (close to the blood outflow end) of the window structure 48. In this embodiment, the window structure 48 is rectangular. In other embodiments, the window structure 48 can be of any shape, such as triangular, circular, oval or polygonal, as long as the free end 43 extends out of the window structure 47. In this embodiment, other features are the same as those in other embodiments and will not be described in detail here.

[0062] As described above, only the preferred specific embodiments of the present invention are provided, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed by the present invention should be covered by the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. An implant, comprising a tubular stent structure and barbed structures disposed on the stent structure, the stent structure including a circumferentially distributed mesh structure, the barbed structures being receivable into the mesh structure, characterized in that, The barb structure includes an elastic element, One end of the elastic element is connected to the mesh structure to form a connection end; The elastic element is arranged to protrude outward from the support structure to form a first position, and then bend from the first position towards the support structure; A window structure is provided on the elastic element, and a barb structure connected to the window structure is provided in the window structure. The barb structure has a free end, and the free end extends out of the window structure in a direction away from the support structure. The angle formed by the straight line connecting the connection end and the first position and the central axis of the support structure is greater than the angle formed by the straight line connecting the connection end and the free end and the central axis of the support structure.

2. The implant according to claim 1, wherein, The connection end is connected to the distal end of the mesh structure, and the barb structure is connected to the proximal end of the window structure; or, the connection end is connected to the proximal end of the mesh structure, and the barb structure is connected to the distal end of the window structure.

3. The implant according to claim 1, characterized in that, The mesh structure includes a first mesh unit and a second mesh unit. The area of the first mesh unit is larger than the area of the second mesh unit. The size of the second mesh unit is substantially the same as the size of the barb structure, and the barb structure can be received in the second mesh unit.

4. The implant according to claim 3, characterized in that, There is a connection part between two adjacent first mesh units, and the second mesh unit is arranged at the connection part.

5. The implant according to claim 4, wherein The first mesh unit is a hexagonal structure, and one side of one hexagonal structure coincides with one side of another hexagonal structure to form the connection part.

6. The implant according to claim 3, wherein, The support structure can radially contract or radially expand. Along with the radial contraction or radial expansion of the support structure, the first mesh unit is circumferentially compressed or circumferentially expanded along the circumference of the support structure. Among them, at least one arc-shaped convex structure is arranged on the first mesh unit in the axial direction of the support structure, and the arc-shaped convex structure protrudes in a direction away from the first mesh unit.

7. The implant according to claim 1, characterized in that, The free end is a tip structure.

8. The implant according to claim 1, characterized in that, The barb structure and the support structure are formed separately and then connected into one body.

9. The implant according to claim 1, characterized in that, The barb structure and the support structure are integrally formed by cutting a pipe.

10. The implant according to claim 3, wherein, The implant is a heart valve, and the heart valve further includes a valve structure. The valve structure includes a plurality of valve leaflets. The plurality of valve leaflets are mutually attached. Each valve leaflet includes a valve angle, and the valve angle passes through the second mesh unit from the inside to the outside of the support structure.

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