Mass spectrometer data acquisition device and mass spectrometer equipment

Abstract

The present application relates to a mass spectrometer data acquisition device and a mass spectrometer device, the device includes an analog collector, a digital collector and a data analysis device, one end of the analog collector is connected to the electron multiplier of the mass spectrometer, receives an electrical signal from the electron multiplier, and the other end is connected to the data analysis device, one end of the digital collector is connected to the electron multiplier of the mass spectrometer, receives an electrical signal from the electron multiplier, and the other end is connected to the data analysis device. The electrical signal from the electron multiplier is collected by the analog collector and the digital collector, and then sent to the signal analysis device for analysis to obtain a mass spectrum. The analog collector has strong pressure resistance and can detect high-concentration signals. The digital collector has high sensitivity and can detect low-concentration signals. The use of both can expand the acquisition signal range and sensitivity, enhance resolution, improve the accuracy and comprehensiveness of signal acquisition, and reduce costs, thereby improving the reliability of data acquisition.

Description

Technical Field

[0001] The present application relates to the technical field of mass spectrometers, and in particular to a mass spectrometer data acquisition device and a mass spectrometer equipment. Background Art

[0002] A mass spectrometer, also known as a mass spectrometer, is an instrument that separates and detects the composition of substances based on the mass difference of atoms, molecules or molecular fragments of substances, based on the principle that charged particles can be deflected in an electromagnetic field. The detection of a mass spectrometer mainly uses an electron multiplier. The ions from the quadrupole hit the high-energy dynode to generate electrons, which are then passed through the electron multiplier to generate electrical signals. The electrical signals from the multiplier are sent to a computer for storage. After being processed by a computer, these signals can be used to obtain chromatograms, mass spectra and other information.

[0003] The traditional method of collecting ion signals uses an analog collector, which can restore ion signals by recording information such as signal energy, pulse width, and waveform shape. However, this method has a narrow collection width and weak sensitivity, resulting in inaccurate and incomplete signal collection. The traditional signal collection method has low reliability. Summary of the invention

[0004] Based on this, it is necessary to provide a mass spectrometer data acquisition device and a mass spectrometer equipment to address the problem of low reliability of traditional signal acquisition methods.

[0005] A mass spectrometer data acquisition device comprises an analog collector, a digital collector and a data analysis device, wherein one end of the analog collector is connected to the electron multiplier of the mass spectrometer to receive an electrical signal from the electron multiplier, and the other end is connected to the data analysis device; one end of the digital collector is connected to the electron multiplier of the mass spectrometer to receive an electrical signal from the electron multiplier, and the other end is connected to the data analysis device.

[0006] A mass spectrometer device comprises an electron multiplier and the mass spectrometer data acquisition device as described above.

[0007] The mass spectrometer data acquisition device and mass spectrometer equipment include an analog collector, a digital collector and a data analysis device. One end of the analog collector is connected to the electron multiplier of the mass spectrometer to receive the electrical signal from the electron multiplier, and the other end is connected to the data analysis device. One end of the digital collector is connected to the electron multiplier of the mass spectrometer to receive the electrical signal from the electron multiplier, and the other end is connected to the data analysis device. The electrical signal from the electron multiplier is collected by the analog collector and the digital collector, and then sent to the signal analysis device for analysis to obtain a mass spectrum. The analog collector has strong pressure resistance and can detect high-concentration signals. The digital collector has high sensitivity and can detect low-concentration signals. The simultaneous use of the two can expand the acquisition signal range and sensitivity, enhance resolution, improve the accuracy and comprehensiveness of signal acquisition, and reduce costs, thereby improving the reliability of data acquisition.

[0008] In one embodiment, the mass spectrometer data acquisition device further includes a protection device, and the protection device is connected to the electron multiplier.

[0009] In one embodiment, the protection device includes a detector, a protection switch and an electronic adsorbent, the detector is connected to the electron multiplier, the detector is connected to the electronic adsorbent through the protection switch, and the distance between the electronic adsorbent and the digital collector is smaller than the distance between the electronic adsorbent and the analog collector.

[0010] In one embodiment, the electron adsorbing member includes two metal sheets spaced apart from each other.

[0011] In one embodiment, the data analysis device is a FPGA chip.

[0012] In one embodiment, the data analysis device includes a dual-channel acquisition and transmission interface, a data processing module and a data storage module, the analog collector and the digital collector are both connected to the dual-channel acquisition and transmission interface, the dual-channel acquisition and transmission interface is connected to the data processing module, and the data processing module is connected to the data storage module.

[0013] In one of the embodiments, the data analysis device further includes a data upload module, and the data upload module is connected to the data storage module.

[0014] In one embodiment, the data processing module includes an analog data processing module, a digital data processing module, a signal fitting module and a signal superposition module. The analog data processing module and the digital data processing module are both connected to the dual-channel acquisition and transmission interface, and are both connected to the signal fitting module. The signal fitting module is connected to the signal superposition module, and the signal superposition module is connected to the data storage module.

[0015] In one embodiment, the mass spectrometer data acquisition device further includes a host computer, and the host computer is connected to the data analysis device. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 is a structural block diagram of a mass spectrometer data acquisition device in one embodiment;

[0017] Figure 2 is a structural block diagram of a mass spectrometer data acquisition device in another embodiment;

[0018] Figure 3 is a schematic structural diagram of a mass spectrometer data acquisition device in one embodiment;

[0019] Figure 4 FIG. 4 is a flowchart of a mass spectrometer data acquisition device in one embodiment. DETAILED DESCRIPTION

[0020] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is described more comprehensively below through embodiments and in conjunction with the accompanying drawings. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0021] In one embodiment, see Figure 1 , a mass spectrometer data acquisition device is provided, including an analog collector 112, a digital collector 114 and a data analysis device 120, one end of the analog collector 112 is connected to the electron multiplier 210 of the mass spectrometer to receive the electrical signal from the electron multiplier 210, and the other end is connected to the data analysis device 120, one end of the digital collector 114 is connected to the electron multiplier 210 of the mass spectrometer to receive the electrical signal from the electron multiplier 210, and the other end is connected to the data analysis device 120. The electrical signal from the electron multiplier 210 is collected by the analog collector 112 and the digital collector 114, and then sent to the signal analysis device for analysis to obtain a mass spectrum, the analog collector 112 has strong pressure resistance and can detect high-concentration signals, the digital collector 114 has high sensitivity and can detect low-concentration signals, and the simultaneous use of the two can expand the acquisition signal range and sensitivity, enhance resolution, improve the accuracy and comprehensiveness of signal acquisition, and reduce costs, and improve the reliability of data acquisition.

[0022] Specifically, in general, the mass spectrometer includes an ion source 230, a dynode 220 and an electron multiplier 210. The ion source 230 hits the high-energy dynode to generate electrons, and the electrons generate electrical signals through the electron multiplier 210. The ion source 230 is a mixed gas of ions to be tested after being screened by a quadrupole. The dynode 220 is a device for generating electrons by ion collision. It is a specific metal collision object. The amount of electrons generated by ions of different masses colliding with the dynode 220 is different. The electron multiplier 210 performs multi-stage amplification on the electrons generated by the collision of the ion body to form an electron beam, which is output as a current at the output end of the multiplier. The electron multiplier 210 amplifies the electron signal into an electron beam, forming a current signal or a voltage signal, collectively referred to as an electrical signal. The strength of the electrical signal can be directly mapped to the number of ions, that is, the concentration of the ions. The electron multiplier 210 includes multiple stages of electron amplifiers. The specific number of electron amplifiers is determined according to the required amplification factor. The higher the amplification factor, the greater the current intensity formed. However, it generally does not exceed 20 stages of amplification to avoid damaging the receiving device.

[0023] When the mass spectrometer data acquisition device proposed in the present application is applied to a mass spectrometer, the mass spectrometer data acquisition device is connected to the electron multiplier 210 of the mass spectrometer, specifically, the analog collector 112 and the digital collector 114 in the mass spectrometer data acquisition device are connected to the electron multiplier 210. The analog collector 112 is also called ADC (Analog-to-digital converter), which is a type of device used to convert a continuous signal in analog form into a discrete signal in digital form. The digital collector 114 is also called TDC (time-to-digital converter), which is a commonly used time interval measurement circuit that generates a pulse signal after an electron impact. The analog collector 112 has a strong impact resistance and mainly collects high-concentration ion electrical signals. The digital collector 114 generates a pulse signal after an electron impact, has high sensitivity, is easily saturated, and mainly collects low-concentration ion electrical signals. The concentrations of the ion electrical signals collected by the analog collector 112 and the digital collector 114 are not unique. In this embodiment, the analog collector 112 is used to collect ion concentrations between 10 6 -10 9 The signal in the cps range is directly output as an intensity value. The digital collector 114 is used to collect ion concentrations in the range of 0-10 7 The signal within the cps range is output in the form of a square wave pulse. It is understood that in other embodiments, the analog collector 112 and the digital collector 114 can also collect ion electrical signals of other concentrations, which can be selected according to actual needs. The data analysis device 120 is mainly used to synchronously collect the signals transmitted by the analog collector 112 and the digital collector 114, analyze the collected signals, and record the signals of different ions to obtain a mass spectrum.

[0024] In one embodiment, see Figure 2 The mass spectrometer data acquisition device also includes a protection device 130, and the protection device 130 is connected to the electron multiplier 210. The protection device 130 is connected to the electron multiplier 210, and can monitor the electrical signal output by the electron multiplier 210, and realize corresponding functions according to the situation of the electrical signal, thereby playing the role of protecting the device. The specific functions of the protection device 130 vary according to the structure of the protection device 130, and any function that can play a protective role is acceptable as long as a person skilled in the art believes that it can play a protective role.

[0025] In one embodiment, the protection device 130 includes a detector, a protection switch 132 and an electronic adsorbent. The detector is connected to the electron multiplier 210. The detector is connected to the electronic adsorbent through the protection switch 132. The distance between the electronic adsorbent and the digital collector 114 is smaller than the distance between the electronic adsorbent and the analog collector 112.

[0026] Specifically, the detector is connected to the electron multiplier 210, and can detect the concentration of the ion electrical signal output by the electron multiplier 210, and compare the detected ion concentration with the set threshold value. When the detected ion concentration is greater than the set threshold value, a closing instruction is issued to the protection switch 132. After receiving the closing instruction, the protection switch 132 is closed, so that the voltage is attached to the electronic adsorbent, and a magnetic field is generated on the electronic adsorbent, which changes the trajectory of the electron beam and finally adsorbs it to the electronic adsorbent. Since the distance between the electronic adsorbent and the digital collector 114 is less than the distance between the electronic adsorbent and the analog collector 112, the electronic adsorbent is close to the digital collector 114, so that the electron beam cannot reach the digital collector 114, thereby protecting the digital collector 114. Further, after the protection switch 132 is closed, a higher voltage, such as a voltage of 230V, can be connected, and the high voltage is loaded on the electronic adsorbent, thereby forming a strong magnetic field on the electronic adsorbent, which has a stronger adsorption ability for ion electrical signals and a better protection effect on the digital collector 114. The threshold value is not unique and can be determined according to the ion concentration that the digital collector 114 can withstand. In this embodiment, the threshold value is set to 10 7 cps (counts per second), cps is the signal value corresponding to the concentration in the mass spectrum. The digital collector 114 can normally collect concentrations between 10 7 It is understood that in other embodiments, the threshold value may be set to other values, and the protection device 130 may be of other structures, as long as those skilled in the art consider it achievable.

[0027] In one embodiment, the electronic adsorbent includes two metal sheets that are relatively spaced apart. The structure of the electronic adsorbent is not unique. In this embodiment, the electronic adsorbent includes two metal sheets that are relatively spaced apart, and there is a distance between the two metal sheets. The metal sheet has good conductivity. When a voltage is loaded on the metal sheet, a magnetic field is formed to adsorb electrons. Furthermore, the two metal sheets can be arranged in parallel, and the size and spacing of the metal sheets can be adjusted according to actual needs, as long as the technicians in this field believe that it can be achieved.

[0028] In one embodiment, the data analysis device 120 is an FPGA chip. The data analysis device 120 is mainly used to synchronously collect signals transmitted by the analog collector 112 and the digital collector 114, and analyze the collected signals, and record the signals of different ions to obtain a mass spectrum. The type of data analysis device 120 is not unique. In this embodiment, the data analysis device 120 is an FPGA (Field Programmable Gate Array) chip, which can implement multiple functions on one chip, making the subsequent design more flexible. It can be understood that in other embodiments, the data analysis device 120 can also be other types of devices, as long as those skilled in the art believe that it can be implemented.

[0029] In one embodiment, see Figure 2 The data analysis device 120 includes a dual-channel acquisition and transmission interface 122, a data processing module 124 and a data storage module 126. The analog collector 112 and the digital collector 114 are both connected to the dual-channel acquisition and transmission interface 122, the dual-channel acquisition and transmission interface 122 is connected to the data processing module 124, and the data processing module 124 is connected to the data storage module 126.

[0030] Specifically, the analog collector 112 and the digital collector 114 are both connected to the dual-channel acquisition transmission interface 122, and the dual-channel acquisition transmission interface 122 can synchronously acquire the signals sent by the analog collector 112 and the data collector, so as to facilitate the subsequent devices to process the signals. The type of the dual-channel acquisition transmission interface 122 is not unique. In the present embodiment, the dual-channel acquisition transmission interface 122 is a differential SPI interface (Serial Peripheral Interface), and the differential SPI interface supports full-duplex communication. As the dual-channel acquisition transmission interface 122, the communication is simple and the data transmission rate is fast. It can be understood that in other embodiments, the dual-channel acquisition transmission interface 122 can also be of other types, as long as it can be implemented by those skilled in the art.

[0031] After the dual-channel acquisition transmission interface 122 acquires the signals transmitted by the analog acquisition device 112 and the digital acquisition device 114, the acquired signals are sent to the data processing module 124 for processing, and the data processing module 124 sends the processed signals to the data storage module 126 for storage, and the stored data can be directly called when needed, which is convenient to use. The specific process of the data processing module 124 processing the data is not unique, and can be adjusted according to the situation of the acquired signal and the processing purpose, as long as it can be implemented by those skilled in the art.

[0032] In one embodiment, see Figure 2 The data analysis device 120 also includes a data upload module 128, which is connected to the data storage module 126. The data upload module 128 is connected to the data storage module 126, and the data storage module 126 can send its own stored data to the data upload module 128. The data upload module 128 can be connected to the host computer 300 or other devices to transmit the data to the host computer 300 or other devices, and the host computer 300 and other devices can further process the device. Specifically, the data storage module 126 can actively send the stored data to the data upload module 128 in real time or at a preset time interval, and the data upload module 128 can also actively upload the received data to the host computer 300 and other devices in real time or at a preset time interval, so as to realize automatic processing and automatic uploading of data. Alternatively, the data storage module 126 and / or the data upload module 128 may also send the received data to the next device connected thereto in sequence after receiving the upload instruction. The upload instruction received by the data upload module 128 may be sent by a device such as the host computer 300, and the upload instruction received by the data storage module 126 may be sent by the data upload module 128. Furthermore, the data upload module 128 may also upload the data to a device such as the host computer 300 according to a preset data transmission protocol to improve the quality of data transmission. Among them, the preset data transmission protocol may be provided by the host computer 300 for the data upload module 128 to transmit data.

[0033] In one embodiment, see Figure 3 The data processing module 124 includes an analog data processing module 1242, a digital data processing module 1244, a signal fitting module 1246 and a signal superposition module 1248. The analog data processing module 1242 and the digital data processing module 1244 are both connected to the dual-channel acquisition and transmission interface 122, and are both connected to the signal fitting module 1246. The signal fitting module 1246 is connected to the signal superposition module 1248, and the signal superposition module 1248 is connected to the data storage module 126.

[0034] The functions of the analog data processing module 1242 and the digital data processing module 1244 are not unique. In this embodiment, the analog data processing module 1242 performs bit width matching and synchronization matching on the data transmitted from the analog collector 112, and the digital data processing module 1244 counts the pulses transmitted from the data collector, and performs bit width matching and synchronization matching at the same time. When the signal fitting module 1246 is working, there are three situations of the signal to be fitted: only ADC signal, only TDC count, and both ADC signal and TDC count. The signal fitting module 1246 fits the signals of the three situations into frame signal data. The signal superposition module 1248 superimposes multiple frame signals in time sequence to improve the resolution and avoid errors in a certain acquisition signal.

[0035] Specifically, different analog data processing modules 1242 and digital data processing modules 1244 have different bit widths for collecting data. In this embodiment, a 16-bit bit width, i.e., 2 bytes, is used. This bit width can also be notified to the host computer 300 to avoid data confusion. Due to the need for superposition, the bit width is expanded from 2 bytes to 4 bytes, and the host computer 300 sequentially uses each 4 bytes as a collected data. Synchronous matching means that each collection must start and end at the same time, so that the ADC and TDC signals collected each time can be matched, and there will be no confusion. Fitting into a frame signal means that each group of collected signals is judged by the start and end indications to determine whether the number of points collected is consistent with the number of points required for a frame of data. If they are consistent, it is considered that this collection is correct and stored as a frame signal, otherwise it is considered that an error is discarded and reported. After each collection, the data obtained is stored, and the data collected next time is accumulated in a frame format, and the previous storage is overwritten after accumulation. Multiple accumulations can avoid spectrum errors caused by a single acquisition error and can distinguish useful signals from interference or noise signals more clearly. This is because useful signals are strong and have large values, while useless signals are weak and have small values. After accumulation, the difference between useful signals and useless signals can be more obvious.

[0036] Correspondingly, when the data processing module 124 includes an analog data processing module 1242, a digital data processing module 1244, a signal fitting module 1246 and a signal superposition module 1248, the data storage module 126 stores the completed frame signal and waits for uploading. After receiving the upload instruction, the data upload module 128 reads the frame data from the data storage module 126 in sequence, combines it in the format of the transmission protocol, and sends it out. The host computer 300 obtains the frame data, can send a valid upload instruction, and provides the corresponding transmission protocol to the FPGA for the FPGA to transmit data.

[0037] In one embodiment, see Figure 2 The mass spectrometer data acquisition device also includes a host computer 300 , and the host computer 300 is connected to the data analysis device 120 .

[0038] Specifically, the host computer 300 obtains data from the data upload module 128, and can further process the data, or set a transmission protocol to the data analysis device 120 for the data analysis device 120 to transmit data. When the data processing module 124 includes an analog data processing module 1242, a digital data processing module 1244, a signal fitting module 1246, and a signal superposition module 1248, the data obtained by the host computer 300 is frame data. It can be understood that in other embodiments, the host computer 300 may also have other functions, such as displaying the obtained mass spectrum, or sending the obtained mass spectrum to a remote terminal for display, so that the operator can obtain the mass spectrum results in time and improve the reliability of the mass spectrometer data acquisition device.

[0039] The mass spectrometer data acquisition device comprises an analog collector 112, a digital collector 114 and a data analysis device 120. One end of the analog collector 112 is connected to the electron multiplier 210 of the mass spectrometer to receive the electrical signal from the electron multiplier 210, and the other end is connected to the data analysis device 120. One end of the digital collector 114 is connected to the electron multiplier 210 of the mass spectrometer to receive the electrical signal from the electron multiplier 210, and the other end is connected to the data analysis device 120. The electrical signal from the electron multiplier 210 is collected by the analog collector 112 and the digital collector 114, and then sent to the signal analysis device for analysis to obtain a mass spectrum. The analog collector 112 has strong pressure resistance and can detect high-concentration signals. The digital collector 114 has high sensitivity and can detect low-concentration signals. The simultaneous use of the two can expand the range and sensitivity of the collected signals, enhance the resolution, improve the accuracy and comprehensiveness of signal collection, reduce costs, and improve the reliability of data collection.

[0040] In one embodiment, see Figure 3 , a mass spectrometer device is provided, including an electron multiplier 210 and a mass spectrometer data acquisition device as described above.

[0041] The mass spectrometer data acquisition device is connected to the electron multiplier 210 of the mass spectrometer, specifically, the analog collector 112 and the digital collector 114 in the mass spectrometer data acquisition device are connected to the electron multiplier 210, the analog collector 112 is used to convert the continuous signal in analog form into a discrete signal in digital form, and the digital collector 114 is a commonly used time interval measurement circuit, which generates a pulse signal after an electron impact. The analog collector 112 has a strong impact resistance and mainly collects high-concentration ion electrical signals. The digital collector 114 generates a pulse signal after an electron impact, has high sensitivity, is easily saturated, and mainly collects low-concentration ion electrical signals. The concentrations of the ion electrical signals collected by the analog collector 112 and the digital collector 114 are not unique. In this embodiment, the analog collector 112 is used to collect ion concentrations between 106 -10 9 The signal in the cps range is directly output as an intensity value. The digital collector 114 is used to collect ion concentrations in the range of 0-10 7 The signal within the cps range is output in the form of a square wave pulse. It is understood that in other embodiments, the analog collector 112 and the digital collector 114 can also collect ion electrical signals of other concentrations, which can be selected according to actual needs. The data analysis device 120 is mainly used to synchronously collect the signals transmitted by the analog collector 112 and the digital collector 114, analyze the collected signals, and record the signals of different ions to obtain a mass spectrum.

[0042] See also Figure 3 The mass spectrometer also includes an ion source 230 and a dynode 220. The ion source 230 hits the high-energy dynode to generate electrons, and the electrons generate electrical signals through the electron multiplier 210. The ion source 230 is a mixed gas of ions to be tested after being screened by a quadrupole. The dynode 220 is a device for generating electrons by ion collision. It is a specific metal collision object. The amount of electrons generated by ions of different masses colliding with the dynode 220 is different. The electron multiplier 210 performs multi-stage amplification on the electrons generated by the collision of the ion body to form an electron beam, which is output as a current at the output end of the multiplier. The electron multiplier 210 amplifies the electron signal into an electron beam, forming a current signal or a voltage signal, collectively referred to as an electrical signal. The strength of the electrical signal can be directly mapped to the number of ions, that is, the concentration of the ions. The electron multiplier 210 includes a multi-stage electron amplifier. The specific number of the electron amplifier is determined by the magnification multiple required. The higher the magnification multiple, the greater the current intensity formed, but generally does not exceed 20 levels of amplification to avoid damaging the receiving device.

[0043] In order to better understand the above embodiment, a detailed explanation is given below in conjunction with a specific embodiment. In one embodiment, the mass spectrometer device includes an ion source 230, a dynode 220, an electron multiplier 210 and a mass spectrometer data acquisition device, the mass spectrometer data acquisition device includes an analog collector 112, a digital collector 114, a data analysis device 120, a protection device 130 and a host computer 300, and the dual-mode receiver includes an analog collector 112, a digital collector 114 and a protection device 130. Among them, the protection device 130 includes a detector, a protection switch 132 and an electronic adsorbent, and the electronic adsorbent is two metal sheets arranged relatively spaced apart. The ion source 230 hits the high-energy dynode to generate electrons, and the electrons generate electrical signals through the electron multiplier 210. The electrical signals are received by the dual-mode receiver and converted into digital signals, which are collected by the FPGA. The signals of different ions are recorded to obtain the mass spectrum. The ADC and TDC in the dual-mode receiver can complement each other to detect proton signals of different concentrations. The ADC has low sensitivity and strong pressure resistance, which is suitable for detecting high-concentration signals. The TDC has high sensitivity and weak pressure resistance, which is suitable for detecting low-concentration signals. A voltage switch is used to protect the TDC in high-concentration signals to extend its service life. The FPGA is used for high-speed acquisition and transmission to achieve synchronous acquisition of the ADC and TDC.

[0044] The ion source 230 is a mixed gas of ions to be tested after being screened by a quadrupole. The dynode 220 is a device for generating electrons by ion collision. Ions of different masses collide with the dynode 220 to generate different amounts of electrons. The electron multiplier 210 is composed of a multi-stage electron amplifier, which amplifies the electron signal into an electron beam, forming a current signal or a voltage signal, collectively referred to as an electrical signal. The strength of the electrical signal can be directly mapped to the number of ions, that is, the concentration of the ions. The specific number of electron amplifiers is determined by the magnification multiple required. The higher the magnification multiple, the greater the current intensity formed. Generally, no more than 20 levels of amplification are used to avoid damaging the receiving device.

[0045] The dual-mode receiver includes an analog receiving mode, a digital receiving mode and a protection device 130. The analog receiving mode uses ADC as the main acquisition channel, which has strong impact resistance and mainly collects high-concentration ion electrical signals, hereinafter referred to as the analog collector 112. The digital receiving mode uses TDC as the main acquisition channel, which is characterized by high sensitivity and easy saturation. It mainly collects low-concentration ion electrical signals, hereinafter referred to as the digital collector 114. The TDC acquisition channel generates a pulse signal after being impacted by electrons. When the ion concentration reaches the set threshold value, the protection switch 132 is turned on and high voltage is used to absorb electrons, so that the electron beam cannot reach the digital acquisition channel, thereby protecting the TDC collector. The protection switch 132 needs to set a threshold value. When the ion concentration exceeds the threshold, the detector sends a protection instruction to turn on the switch, and the concentration is set to 10 7, is set according to the range that TDC can withstand. There are two protective metal sheets near the TDC receiver. During normal acquisition, the protection switch 132 is closed. When the electron beam formed by high-concentration ions comes over, the detector will detect that its value exceeds the threshold and turn on the protection switch 132. After the protection fast switch is turned on, high voltage will be attached to the metal sheet, forming a strong magnetic field, changing the trajectory of the electron beam and finally adsorbing it to the metal sheet. The high voltage here is 230V.

[0046] The data analysis device 120 is an FPGA chip, which includes a dual-channel acquisition transmission interface 122, a data processing module 124, a data storage module 126, and a data upload module 128. The dual-channel acquisition transmission interface 122 is connected to the analog collector 112 and the digital collector 114 respectively, and synchronously collects the signals transmitted by the analog collector 112 and the digital collector 114. The analog collector 112 directly transmits digital signals, and the digital collector 114 transmits pulses. A counter is used inside the FPGA to count the number of ion collisions. The data processing module 124 fits the analog acquisition signal and the digital acquisition signal into the same group of signals, and the fitted signal is superimposed frame by frame according to the requirements to enhance the resolution. The data storage module 126 stores the processed frame signal. After receiving the upload instruction, the data upload module 128 uploads the stored frame signal to the required device, which can be the host computer 300 or other devices.

[0047] Furthermore, the ion source 230 is a screened ion body to be tested. The dynode 220 is a specific metal collision object. Different ions collide with the metal surface and generate electrons of different magnitudes. The electron multiplier 210 performs multi-stage amplification on the electrons generated by the collision of the ions to form an electron beam, which is output as a current at the output end of the multiplier. The analog collector 112 is used to collect ion concentrations in the range of 10 6 -10 9 The signal in the cps range is directly output as an intensity value. The digital collector 114 is used to collect ion concentrations in the range of 0-10 7 The signal in the cps range is output in the form of square wave pulses. The protection switch 132 is turned on when the concentration reaches 10 7cps, a high-voltage signal is generated to absorb high-concentration electrons to protect the TDC collector. The dual-channel acquisition transmission interface 122 uses a differential spi interface for transmission and performs synchronous acquisition on the FPGA side. The ADC data module performs bit width matching and synchronization matching on the data transmitted from the ADC channel inside the FPGA. The TDC pulse counting module counts the TDC pulses and performs bit width matching and synchronization matching at the same time. The signal fitting module 1246 has three situations: only ADC signal, only TDC count, and both ADC signal and TDC count. The module fits the signals of the three situations into frame signal data. The signal superposition module 1248 superimposes multiple frame signals in time sequence to improve resolution and avoid errors in a certain acquisition signal. The data storage module 126 stores the completed frame signal and waits for upload. The data upload module 128 receives the upload instruction, reads the frame data from the storage module in sequence, and sends it out according to the format combination of the transmission protocol. The host computer 300 / other devices need to obtain frame data, can send valid upload instructions, and provide corresponding transmission protocols to FPGA for FPGA to transmit data.

[0048] Different analog data processing modules 1242 and digital data processing modules 1244 have different bit widths for collecting data. In this embodiment, a 16-bit bit width, i.e., 2 bytes, is used. This bit width can also be notified to the host computer 300 to avoid data confusion. Due to the need for superposition, the bit width is expanded from 2 bytes to 4 bytes, and the host computer 300 sequentially uses each 4 bytes as a collected data. Synchronous matching means that each collection must start and end at the same time, so that the ADC and TDC signals collected each time can be matched, and there will be no confusion. Fitting into a frame signal means that each group of collected signals is judged by the start and end indications to determine whether the number of points collected is consistent with the number of points required for a frame of data. If they are consistent, it is considered that this collection is correct and stored as a frame signal, otherwise it is considered to be an error and discarded and reported. After each collection, the data obtained is stored, and the data collected next time is accumulated in a frame format, and the previous storage is overwritten after accumulation. Multiple accumulations can avoid spectrum errors caused by a single acquisition error and can distinguish useful signals from interference or noise signals more clearly. This is because useful signals are strong and have large values, while useless signals are weak and have small values. After accumulation, the difference between useful signals and useless signals can be more obvious.

[0049] like Figure 4 As shown, it is a workflow diagram of the mass spectrometer data acquisition device, and the process includes the following steps:

[0050] Step 201, the ion source 230 begins to enter the system;

[0051] Step 202, generating electrons on the dynode 220 through collision;

[0052] Step 203, electrons are input into the electron multiplier 210, and a current signal is output;

[0053] Step 204, the dual-mode receiver receives ion signals of different concentrations respectively;

[0054] Step 205, FPGA synchronously receives dual-mode signals;

[0055] Step 206, FPGA performs signal fitting;

[0056] Step 207, FPGA caches the fitting signal and waits for the next signal to be superimposed;

[0057] Step 208, FPGA stores the superimposed signal and waits for an upload instruction;

[0058] Step 209, after receiving the upload instruction, the FPGA proceeds to step 210 to upload the data. If no upload instruction is received, the FPGA proceeds to step 208 and continues to wait for the upload instruction.

[0059] The mass spectrometer device includes an analog collector 112, a digital collector 114 and a data analysis device 120. One end of the analog collector 112 is connected to the electron multiplier 210 of the mass spectrometer to receive the electrical signal from the electron multiplier 210, and the other end is connected to the data analysis device 120. One end of the digital collector 114 is connected to the electron multiplier 210 of the mass spectrometer to receive the electrical signal from the electron multiplier 210, and the other end is connected to the data analysis device 120. The electrical signal from the electron multiplier 210 is collected by the analog collector 112 and the digital collector 114, and then sent to the signal analysis device for analysis to obtain a mass spectrum. The analog collector 112 has strong pressure resistance and can detect high-concentration signals. The digital collector 114 has high sensitivity and can detect low-concentration signals. The simultaneous use of the two can expand the range and sensitivity of the collected signals, enhance the resolution, improve the accuracy and comprehensiveness of signal collection, reduce costs, and improve the reliability of data collection.

[0060] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0061] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A mass spectrometer data acquisition device, characterized in that: The invention comprises an analog collector, a digital collector and a data analysis device, wherein one end of the analog collector is connected to the electron multiplier of the mass spectrometer to receive the electrical signal from the electron multiplier, and the other end is connected to the data analysis device; one end of the digital collector is connected to the electron multiplier of the mass spectrometer to receive the electrical signal from the electron multiplier, and the other end is connected to the data analysis device; the data analysis device is used to synchronously collect the electrical signals transmitted by the analog collector and the digital collector, and analyze the collected electrical signals; wherein the analog collector is used to collect the electrical signals of the ion concentration between 10 6 -10 9 The signal in the cps range is directly output as an intensity value; the digital collector is used to collect ion concentrations in the range of 0-10 7 Signals in the cps range are output in the form of square wave pulses; The mass spectrometer data acquisition device also includes a protection device, which is connected to the electron multiplier; the protection device includes a detector, a protection switch and an electronic adsorbent, the detector is connected to the electron multiplier, the detector is connected to the electronic adsorbent through the protection switch, the distance between the electronic adsorbent and the digital collector is smaller than the distance between the electronic adsorbent and the analog collector; the electronic adsorbent includes two metal sheets arranged relatively spaced apart; Among them, the data analysis device includes a dual-channel acquisition and transmission interface, a data processing module and a data storage module, the analog collector and the digital collector are both connected to the dual-channel acquisition and transmission interface, the dual-channel acquisition and transmission interface is connected to the data processing module, and the data processing module is connected to the data storage module; the data processing module includes an analog data processing module, a digital data processing module, a signal fitting module and a signal superposition module, the analog data processing module and the digital data processing module are both connected to the dual-channel acquisition and transmission interface, and are both connected to the signal fitting module, the signal fitting module is connected to the signal superposition module, and the signal superposition module is connected to the data storage module.

2. The mass spectrometer data acquisition device according to claim 1, characterized in that: The data analysis device is a FPGA chip.

3. The mass spectrometer data acquisition device according to claim 1, characterized in that: The data analysis device further comprises a data uploading module, and the data uploading module is connected to the data storage module.

4. The mass spectrometer data acquisition device according to claim 1, characterized in that: It also includes a host computer, which is connected to the data analysis device.

5. A mass spectrometer device, characterized in that: It comprises an electron multiplier and a mass spectrometer data acquisition device as described in any one of claims 1 to 4.

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