Medical devices for endoscopic dispensing of medications and related methods of use

Abstract

A medical system includes a propellant source containing a propellant fluid, a container containing a material, and a shaft having a plurality of lumens, each of the plurality of lumens having a first opening at a proximal end of the shaft and a second opening at a distal end of the shaft. The plurality of lumens are fluidly coupled to one or more of the propellant source and at least one of the plurality of containers, with a first lumen surrounding at least one other lumen, being coaxial therewith, or being juxtaposed therewith.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims the benefit of priority to U.S. Provisional Application No. 62 / 936,765, filed on November 18, 2019, which is incorporated herein by reference in its entirety. Technical Field

[0003] The present invention generally relates to endoscopic medical devices and related methods of use. More particularly, in some embodiments, the present invention relates to endoscopic medical tools and methods related to accessing a target site and dispensing fluids and / or medicaments to the target site. Background Art

[0004] A medical tool for dispensing fluids and / or therapeutic agents to a target tissue, for example, to create a protective layer using an adhesive to minimize bleeding, can include a catheter having a dispensing tip. Disadvantages of endoscopic systems using such tools include, for example, clogging of the dispensing tip with the adhesive, which typically cures rapidly once mixed. This clogging prevents further dispensing of the adhesive material. The dispensing tip or the entire endoscopic device may need to be replaced, requiring the device to be removable from the patient. This increases surgical time and may cause the user to lose track of the treatment site when reinserting the endoscopic device into the patient. The present invention can address one or more of these or other problems in the art. However, the scope of the invention is defined by the appended claims, rather than by its ability to address a particular problem. Summary of the Invention

[0005] A medical system includes a propellant source configured to contain a propellant fluid; a plurality of containers each configured to contain a material; and a shaft having a plurality of lumens, each of the plurality of lumens having a first opening at a proximal end of the shaft and a second opening at a distal end of the shaft. The plurality of lumens are fluidly coupled to one or more of the propellant source and at least one of the plurality of containers, and a first lumen of the plurality of lumens surrounds, is coaxial with, or is juxtaposed with at least one other lumen of the plurality of lumens.

[0006] A propellant source may be fluidly coupled to each of the plurality of containers and to the first chamber.

[0007] The shaft may include a tip at a distal-most end of the shaft, the tip including structure for mixing contents within the shaft.

[0008] The tip may include a distal opening; a passage connecting at least one of the plurality of lumens of the shaft to the distal opening; and an auger rotatably disposed in the passage and configured to move material with the passage toward the distal opening.

[0009] The material in a first container in the plurality of containers may be a first medicament, and the material in a second container in the plurality of containers may be a second medicament different from the first medicament.

[0010] The propellant fluid may be a gas configured to mix with the first medicament in the first container and with the second medicament in the second container, and the gas may transport each of the first and second medicaments through a respective lumen of the plurality of lumens.

[0011] The first and second medicaments can be configured to contact each other to form a mixture at or near the distal opening of the shaft, and at least one of the adhesion, viscosity, and therapeutic property of the mixture can be greater than the adhesion, viscosity, and therapeutic property of each of the first and second medicaments, respectively.

[0012] The gas from the first chamber may be configured to form an atomized mixture.

[0013] At least one of the plurality of containers may be a syringe. The syringe may include a barrel having an inlet at a proximal end of the barrel, an outlet at a distal end of the barrel, and a chamber between the inlet and the outlet; and a piston configured to be inserted into the inlet and moved relative to the barrel, wherein material in the chamber may be configured to be discharged from the outlet by moving the piston toward the outlet.

[0014] Each lumen of the plurality of lumens may be fluidly isolated from other lumens of the plurality of lumens from the first opening of each lumen to the second opening of each lumen.

[0015] The propellant source may be fluidly coupled directly to the first lumen, wherein an inlet of each of the plurality of containers may be fluidly coupled to the propellant source, and an outlet of each of the plurality of containers may be fluidly coupled to a respective lumen of the plurality of lumens at the proximal end of the shaft.

[0016] The plurality of cavities fluidly coupled to the plurality of containers may share a common wall, and wherein the first cavity surrounds the plurality of cavities fluidly coupled to the plurality of containers.

[0017] An actuator may be coupled to the outlet of the propellant source, the first chamber, and each of the plurality of containers, wherein the actuator may be configured to control the release of the propellant fluid from the propellant source.

[0018] The actuator may be configured to individually control release of the propellant fluid to the first chamber and each of the first and second containers of the plurality of containers, and wherein the propellant fluid may be configured to atomize a mixture of the first and second materials at the distal end of the shaft.

[0019] The propellant source may be directly fluidically coupled to an inlet of a first container of the plurality of containers, and the first container may be configured to contain a liquid. The propellant source may be directly fluidically coupled to an inlet of a second container of the plurality of containers, and the second container may be configured to contain a powder. The propellant fluid may be configured to transfer the liquid through a first lumen and the powder through a second lumen, the second lumen may be fluidically isolated from the first lumen, the fluid and the powder may be configured to contact each other to form a mixture at or near the distal opening of the shaft, and wherein at least one of the adhesion, viscosity, and therapeutic property may be greater than the adhesion, viscosity, and therapeutic property of each of the fluid and the powder, respectively.

[0020] A medical system includes a propellant source configured to contain a propellant fluid; a plurality of containers each configured to contain a material; and a shaft having a plurality of lumens, each of the plurality of lumens having a first opening at a proximal end of the shaft and a second opening at a distal end of the shaft. The plurality of lumens are fluidly coupled to one or more of the propellant source and at least one of the plurality of containers, and a first lumen of the plurality of lumens surrounds, is coaxial with, or is juxtaposed with at least one other lumen of the plurality of lumens.

[0021] A propellant source may be fluidly coupled to each of the plurality of containers and to the first chamber.

[0022] The shaft may include a tip at a distal-most end of the shaft, the tip including structure for mixing contents within the shaft.

[0023] The tip may include a distal opening; a passage connecting at least one of the plurality of lumens of the shaft to the distal opening; and an auger rotatably disposed in the passage and configured to move material with the passage toward the distal opening.

[0024] The material in a first container in the plurality of containers may be a first medicament, and the material in a second container in the plurality of containers may be a second medicament different from the first medicament.

[0025] The propellant fluid may be a gas configured to mix with the first medicament in the first container and with the second medicament in the second container, and the gas may transport each of the first and second medicaments through a respective lumen of the plurality of lumens.

[0026] The first and second medicaments can be configured to contact each other to form a mixture at or near the distal opening of the shaft, and at least one of the adhesion, viscosity, and therapeutic property of the mixture can be greater than the adhesion, viscosity, and therapeutic property of each of the first and second medicaments, respectively.

[0027] The gas from the first chamber may be configured to form an atomized mixture.

[0028] At least one of the plurality of containers may be a syringe. The syringe may include a barrel having an inlet at a proximal end of the barrel, an outlet at a distal end of the barrel, and a chamber between the inlet and the outlet; and a piston configured to be inserted into the inlet and moved relative to the barrel, wherein material in the chamber may be configured to be discharged from the outlet by moving the piston toward the outlet.

[0029] Each lumen of the plurality of lumens may be fluidly isolated from other lumens of the plurality of lumens from the first opening of each lumen to the second opening of each lumen.

[0030] The propellant source may be fluidly coupled directly to the first lumen, wherein an inlet of each of the plurality of containers may be fluidly coupled to the propellant source, and an outlet of each of the plurality of containers may be fluidly coupled to a respective lumen of the plurality of lumens at the proximal end of the shaft.

[0031] The plurality of cavities fluidly coupled to the plurality of containers may share a common wall, and wherein the first cavity surrounds the plurality of cavities fluidly coupled to the plurality of containers.

[0032] An actuator may be coupled to the outlet of the propellant source, the first chamber, and each of the plurality of containers, wherein the actuator may be configured to control the release of the propellant fluid from the propellant source.

[0033] The actuator may be configured to individually control release of the propellant fluid to the first chamber and each of the first and second containers of the plurality of containers, and wherein the propellant fluid may be configured to atomize a mixture of the first and second materials at the distal end of the shaft.

[0034] The propellant source may be directly fluidically coupled to an inlet of a first container of the plurality of containers, and the first container may be configured to contain a liquid. The propellant source may be directly fluidically coupled to an inlet of a second container of the plurality of containers, and the second container may be configured to contain a powder. The propellant fluid may be configured to transfer the liquid through a first lumen and the powder through a second lumen, the second lumen may be fluidically isolated from the first lumen, the fluid and the powder may be configured to contact each other to form a mixture at or near the distal opening of the shaft, and wherein at least one of the adhesion, viscosity, and therapeutic property may be greater than the adhesion, viscosity, and therapeutic property of each of the fluid and the powder, respectively.

[0035] A medical system includes a propellant source containing a propellant gas; a first container fluidly coupled to the propellant source and containing a powdered medicament; a second container fluidly coupled to the propellant source and containing a fluid; and a shaft having a first lumen fluidly coupled to the first container, a second lumen fluidly coupled to the second container, and a third lumen fluidly coupled to the propellant source, wherein the propellant gas propels the powdered medicament through the first lumen and propels the fluid through the second lumen such that the fluid mixes with the powdered medicament distally of distal openings of the first and second lumens.

[0036] A first material can be flowed through a first lumen of the shaft via a propellant fluid, a second material different from the first material can be flowed through a second lumen of the shaft via a propellant fluid, wherein the first lumen can be coaxial with, alongside, or surrounding the second lumen, and the mixture of the first and second materials can be applied to tissue adjacent to the distal-most end of the shaft.

[0037] The shaft may be inserted into a natural orifice of the body, the shaft may be advanced to a target site of the gastrointestinal (GI) tract of the body, and the mixture may be applied to tissue at the target site.

[0038] The mixture can be configured to adhere to tissue of the GI tract, and the material can include a therapeutic agent.

[0039] The propellant gas may flow through a third lumen of the shaft, thereby surrounding the first and second lumens, wherein applying the mixture may include atomizing the mixture with the propellant gas at or near a distal-most end of the shaft. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate various exemplary embodiments and, together with the description, serve to explain the principles of the disclosed embodiments.

[0041] Figure 1 is a schematic diagram of a medical system according to one embodiment;

[0042] Figure 2 According to one embodiment, the Figure 1 cross-section of medical devices in the healthcare system;

[0043] Figure 3 According to one embodiment Figure 1 catheter tips for use with medical systems;

[0044] Figure 4 is a schematic diagram of another example of a medical system according to one embodiment;

[0045] Figure 5 is a schematic diagram of another example of a medical system according to one embodiment;

[0046] Figure 6 is a schematic diagram of another example of a medical system according to one embodiment; and

[0047] Figure 7 is according to one embodiment along line 7-7 Figure 6 Cross section of a medical system with a medical device. DETAILED DESCRIPTION

[0048] The present invention is described with reference to exemplary medical systems and medical tools for accessing a target site and dispensing one or more medicaments, for example, a plurality of fluids (once mixed, forming an adhesive gel or liquid and / or a regenerative agent). Such medicaments or fluids can minimize delayed bleeding in a patient's body. However, it should be noted that reference to any particular surgery and / or any particular medicament is provided only for convenience and is not intended to limit the present invention. Those of ordinary skill in the art will recognize that the concepts upon which the disclosed devices and application methods are based can be used in any suitable surgery, medicine or other aspects. The present invention can be understood with reference to the following description and accompanying drawings, in which identical elements are indicated by identical reference numerals.

[0049] For ease of description, portions of the disclosed device and / or its components will be referred to as proximal and distal portions. It should be noted that the term "proximal" is intended to refer to the portion that is closer to the user of the device, and the term "distal" is used herein to refer to the portion that is further away from the user. Similarly, extending "distally" indicates that the component extends in a distal direction, and extending "proximally" indicates that the component extends in a proximal direction. Furthermore, as used herein, the terms "approximately," "about," and "substantially" indicate a range of values ​​within + / - 10% of a stated or implied value. Additionally, terms indicating the geometry of a component / surface refer to both precise and approximate shapes.

[0050] refer to Figure 1 , shows a medical system 10 according to one embodiment. The medical system 10 includes a propellant fluid containing device 20, a first container 30 and a second container 40 for containing first and second medicaments, respectively, and a conduit 50 (e.g., a shaft). These components can be directly connected or can be connected by tubes, hoses, valves, etc., as will be described herein.

[0051] Containment device 20 is configured to contain a propellant fluid, such as a gas, for example, carbon dioxide, or any other gas or fluid known in the art, for dispensing a material, such as a drug powder or reagent, to a target location within a patient's body. Although illustrated as a polygonal container, containment device 20 can be any shape, such as a sphere, or any other shape known in the art for containing a gas. For example, containment device 20 can be a carbon dioxide canister or cylinder typically found in a medical setting, such as a hospital, and can be connected to various components of medical system 10 via one or more conduits, as will be described herein. Containment device 20 can include one or more outer walls defining one or more inner chambers (not shown) configured to contain the propellant fluid. The walls of containment device 20 can be formed from any material suitable for containing a propellant fluid, such as, but not limited to, a metal alloy, a ceramic, or other materials known in the art. The propellant fluid contained within the inner chambers of containment device 20 can be under pressure. Thus, the walls can be formed from a material and / or thickness suitable for containing the propellant fluid under pressure, for example, from about 5 pounds per square inch (PSI) to about 40 PSI, but not limited thereto. For example, the gas that can be contained in containment device 20 includes CO2 or other similar gases used to propel materials from the medical device into the body. It should be understood that these gases are examples and are not limited to the types of gases contained in containment device 20.

[0052] Continue to refer Figure 1 , the containment device 20 is fluidly connected to the conduit 50 via the first conduit 22, to the first container 30 via the second conduit 24, and to the second container 40 via the third conduit 26. Although not shown, the containment device 20 may include one or more actuators and valves for controlling the release of the propellant fluid to each of the first conduit 22, the second conduit 24, and the third conduit 26. Alternatively or additionally, an actuator (such as Figure 5The actuating device described herein can be used to control the release of the propellant fluid from the containment device 20. As will be understood by one of ordinary skill in the art, varying the amount of propellant fluid released from the containment device 20 to each of the first and second containers 30, 40 can change the mix ratio of the fluids, solids, or medicaments contained in the first and second containers 30, 40, and / or can change the rate at which the resulting mixture is discharged from the conduit 50, as will be explained in greater detail herein. Additionally or alternatively, one or more pressure regulators can be associated with the containment device 20, the first, second, and third conduits 22, 24, 26, or one or more of the first and second containers 30, 40. The pressure regulators can maintain an appropriate pressure of the propellant gas through the medical system 10. It should be understood that the first, second, and third conduits 22, 24, 26 and other conduits described herein can be any material known for transporting materials used in medical environments. Depending on the desired application, these conduits can be rigid or flexible.

[0053] like Figure 1 As further shown in FIG, a first container 30 and a second container 40 are located downstream of the containment device 20. The first container 30 and the second container 40 can have similar or different characteristics, such as shape, size, etc. The first container 30 and the second container 40 can each contain one or more medicaments in the form of a fluid or solid (including particles), which, once mixed together, are activated to have additional properties, such as adhesion to treat a target site. The first container 30 and the second container 40 can be formed of any material known in the art for containing therapeutic agents or other fluids or solids to be delivered to the human body. For example, the material used to form the first and second containers 30, 40 can be chemically inert to the one or more medicaments contained therein. In addition, the first container 30 and the second container 40 can be designed to withstand the pressure of the propellant gas transmitted from the containment device 20 to each of the first container 30 and the second container 40. Additionally, one or more of the first container 30 and the second container 40 can have fins or other protrusions within the container to help mix the propellant gas and the one or more medicaments to produce a uniform mixture at the downstream outlet of each of the first container 30 and the second container 40. Although in Figure 1 Only two containers are shown in FIG. 1 , but it should be understood that any number of containers may be included in the medical system 10 as appropriate based on the medication, solvent, or other fluid being transferred by the catheter 50 or a fixed quantity.

[0054] like Figure 1As further shown, the downstream outlets of the first container 30 and the second container 40 are connected to the conduit 50 via the fourth conduit 32 and the fifth conduit 42, respectively. The fourth conduit 32 and the fifth conduit 42 each transport a mixture of the contents of the respective container and the propellant fluid from the containing device 20. As will be described herein, each mixture enters a separate chamber at the proximal end 50a of the conduit 50. As explained herein, a regulator can be used to change the pressure of the propellant fluid and / or the mixture of the propellant fluid and any of the agents described herein. For example, one or more regulators can be operably associated with the downstream outlets of one or more of the first container 30 or the second container 40 and / or one or more of the fourth conduit 32 and the fifth conduit 42.

[0055] As will be appreciated, each of the containment device 20, the first container 30, and the second container 40 can be a separate element, such as a containment canister found in a hospital or other medical environment. Alternatively, one or more of the containers can be attached to or contained within the housing and in conjunction with, for example, an actuation device, such as Figure 5 In this manner, the medical system 10 can be handheld or portable.

[0056] refer to Figure 2 , showing the Figure 1 The cross section of the catheter 50 is taken along line 2-2. The catheter 50 may be a shaft (e.g., a flexible sheath, a catheter, a tube, etc.) and includes a second lumen 54 and a third lumen 56, each fluidically separated from the other. The first lumen 52, which is fluidically separated from the second and third lumens 54, 56, is defined by the outermost walls of the second and third lumens 54, 56 and the outermost wall of the catheter 50, and surrounds the second and third lumens 54, 56. Figure 2 As shown, the second and third lumens 54, 56 share a common wall 50c, resulting in a semicircular cross-section for each of the lumens 54 and 56, but it should be understood that the present invention is not limited to this example. For example, the second and third lumens 54, 56 can be independent tubes disposed within the catheter 50, having a space separating these independent tubes, and the space can be fluidically coupled to the first lumen 52. For example, the second and third lumens 54, 56 can be discrete tubes having a circular or other cross-sectional shape. Although not shown, the second lumen 54 and / or the third lumen 56 can be attached to the outer wall of the catheter 50 by one or more protrusions, adhesives, or other means to maintain the appropriate spacing between the second and third lumens 54, 56 and their position relative to the outer wall of the catheter 50. In addition, any one of the first, second, and third lumens 52, 54, 56 can extend to the distal end 50b of the catheter 50. Alternatively, one or more of the first, second, or third lumens 52, 54, 56 can terminate proximally to the distal end 50b of the catheter 50.

[0057] As will be explained in greater detail herein, the propellant fluid from the first lumen 52 may be mixed or otherwise contacted at the distal-most end 50b of the catheter 50 with the reagent and propellant fluids from the second and third lumens 54, 56, respectively (see FIG. Figure 1 ). Once this occurs, the chemical properties of the mixture may change to produce, for example, an adhesive mixture. Additionally or alternatively, after the fluids, reagents, etc. exit at the distal-most end 50b, the combined mixture may activate an agent, such as an antimicrobial agent or other agent, or the agent may have already been activated in one or both of the mixtures originating from the first and second containers 30, 40. After exiting the distal-most end 50b, the additional physical properties of the mixture resulting from the contact / mixing may be different from the physical properties of the reagents or other fluids or mixtures exiting from the first and second containers 30, 40. For example, the resulting mixture may be more viscous, may be an adhesive, may be a gel, and / or may activate a therapeutic agent.

[0058] The method of operating the medical system 10 will now be explained. A catheter 50 is inserted into the patient's body and advanced to the target site. The catheter 50 can be inserted directly into the patient's body without using a guide device, or the catheter 50 can be advanced along an endoscope, guidewire, or other similar device that has previously been advanced to the target site. The catheter 50 can be inserted through a natural orifice, such as the mouth, anus, or through a surgical incision in the body. Once the distal tip of the catheter (e.g., distal tip 50b) is positioned at the target site, the user can activate one or more actuators typically associated with the containment device 20 and / or the medical system 10 to release propellant gas from the device 20 into one or more of the first conduit 22, the second conduit 24, and the third conduit 26. The one or more actuators allow the user to control the amount of propellant fluid flowing in each of the first, second, and third conduits 22, 24, and 26, and thereby control the dispersion rate of the reagent or other fluid or solid in the first and second containers 30, 40. The propellant gas enters the first and second containers 30, 40 and mixes with the reagent, fluid, or solid therein. According to one example, a first mixture of a first agent and a propellant gas travels from the first container 30 to the second chamber 54 via the fourth conduit 32. Similarly, a second mixture of a second agent and a propellant gas can travel from the second container 40 to the third chamber 56 via the fifth conduit 42.

[0059] The first mixture and the second mixture then exit the second chamber 54 and the third chamber 56, respectively, at the distal end 50b of the catheter 50. The first mixture and the second mixture mix with the propellant fluid from the first chamber 52 and, in some embodiments, can be atomized by it. According to one example, mixing the first and second mixtures after leaving the distal end 50b can cause the resulting mixture to be activated or cross-linked, for example, to create a gel or liquid adhesive that can adhere to the target site and / or can activate one or more therapeutic agents in the resulting mixture. When the mixture is dispersed from the distal end 50b of the catheter 50, the catheter 50 can be moved relative to the target site to deposit the resulting mixture at the target site. In this way, the first mixture and the second mixture do not contact each other within the catheter 50, thereby preventing the mixture from becoming an adhesive within the catheter 50 and preventing the adhesive from solidifying within the catheter 50 and completely or partially blocking the outlet of the catheter 50 at the distal end 50b.

[0060] It should be understood that if the catheter 50 is pre-loaded with medicaments, fluids, or solids that are otherwise present in the first and second containers 30, 40, the first and second containers 30, 40 can be removed from the system 10. For example, the second and third lumens 54, 56 can be pre-loaded with different medicaments. According to one example, the containment device 20 can be directly connected to the catheter 50 without the use of any intermediate containers. In this example, the containment device 20 can provide propellant gas directly to the first, second, and third lumens 52, 54, 56, thereby forcing the first and second medicaments to flow downward along the respective second and third lumens 54, 56, and, for example, aerosolizing the mixture of the first and second medicaments at the distal end of the catheter 50 using the propellant gas from the first lumen 52. This can reduce the size of the medical system 10 and allow for greater portability, and can provide more uniform and / or complete distribution of the medicaments at the target site. Alternatively or additionally, if the user determines that additional first and second medicaments need to be dispensed to the target site, the first and second containers 30, 40 can be attached to the respective second and third lumens 54, 56. According to one example, each component of the system 10 can be screw-fitted, snap-fitted, etc. to the other components to enable quick, efficient, and safe addition or removal of components. In this manner, the containment device 20 can be disconnected from the second and third chambers 54, 56, and the first and second containers 30, 40 can be inserted between the containment device 20 and the respective second and third chambers 54, 56.

[0061] exist Figure 3, a catheter tip 60 according to one embodiment is shown. The catheter tip 60 may include an auger 62 for moving and / or mixing one or more of the first mixture and the second mixture toward an outlet 67 (or multiple outlets) located at the distal end 66. The catheter tip 60 may include a tapered portion 64 that tapers toward the distal end 66. The catheter tip 60 may be integrally formed with the catheter 50 or may be attached to the distal end 50b of the catheter 50 by, for example, an adhesive, a snap connection, etc. The catheter tip 60 may be permanently fixed to the catheter 50 or may be removably attached to the catheter 50. The catheter tip 60 may dispense a mixture of medicaments with or without atomizing the medicament. For example, the auger 62 may move the combined first mixture and the second mixture from each of the second cavity 54 and the third cavity 56 located at the distal end 50b of the catheter 50 toward the distal end 66, and may dispense the combined mixture to a target site without atomizing the combined mixture. Alternatively, the combined mixture may be moved toward the distal-most end 66 of the catheter tip 60 and the propellant gas from the first lumen 52 may atomize and propel the combined mixture from the catheter 50 (via the catheter tip 60 ) toward the target site.

[0062] like Figure 3 As shown, the auger 62 may include a single helical thread, wherein the diameter and / or pitch of the thread decreases at the tapered portion 64 of the catheter tip 60, which can increase the accuracy of the distribution of the drug from the catheter tip 60 to the target site. The auger 62 is not limited to a single thread, nor is the auger 62 limited to a thread size and / or pitch. Alternatively, the auger 62 may include a protrusion or threaded surface that causes the drug therein to mix during dispersion. The auger 62 may be driven by any known means, including but not limited to electric or pneumatic drive.

[0063] refer to Figure 4 , shows a medical system 110 according to another example. The device 20, the first conduit 22 and the catheter 50 have Figure 1The medical system 10 of the present invention has similar features to those of the devices in the medical system 10. According to one example, the first syringe 130 contains a first fluid, medication, or other material in a first chamber 130a, and the second syringe 140 contains a second fluid, medication, or other material in a second chamber 140a. The first and second syringes 130, 140 can be any known syringes used in medical systems, including pistons for forcing material from the respective first and second chambers 130a, 140a out of the distal-most ends of the syringe bodies or barrels. The first and second chambers 130a, 140a of the respective first and second syringes 130, 140 can be filled with material, such as medication, therapeutic agent, etc., by removing the pistons, adding material, and reinserting the pistons. Alternatively or additionally, the first and second syringes 130, 140 can be filled through the distal-most ends of the first and second syringes 130, 140 by pulling the pistons proximally to create a vacuum in the first and second chambers 130a, 140a.

[0064] Actuation of the first syringe 130, for example, by forcing the plunger into the body / barrel, causes the first medicament in the first chamber 130a to flow through the second conduit 132 to the second lumen 54. Similarly, actuation of the second syringe 140 causes the second medicament in the second chamber 140a to flow through the third conduit 142 to the third lumen 56. The first and second syringes 130, 140 can be activated individually or simultaneously. Furthermore, the first and second syringes 130, 140 can be actuated by a user, for example, by pushing the proximal ends of the plungers of the first and second syringes 130, 140 by hand or finger. Alternatively or additionally, the first and second syringes 130, 140 can be pneumatically actuated or use mechanical or electrical means to depress the piston of each of the first and second syringes 130, 140. For example, the piston of each of the first and second syringes 130, 140 can be connected to a device having a motor, such as an electric motor, which can actuate the piston of each of the first and second syringes 130, 140 individually or simultaneously. The device may also include a processor and a memory having a program stored thereon that may control the motor to actuate the first and second syringes 130 , 140 .

[0065] The first and second medicaments of the medical system 110 can be dispersed from the distal end 50b of the catheter 50 by, for example, atomizing the mixture of the first and second medicaments using a propellant gas. For example, as discussed above, the first lumen 52 can be arranged around the second and third lumens 54, 56 and can receive the propellant gas from the containment device 20 via the first conduit 22. The propellant gas can force the combined mixture of the first and second medicaments from the distal end 50b of the catheter 50 to flow. Alternatively, Figure 3 The mixing catheter tip 60 can be used to dispense the combined mixture of the first and second medicaments, as described herein.

[0066] refer to Figure 5 , shows another example of a medical system 210. The medical system 210 includes Figure 1 Similar features of the medical system 10. Figure 5 As shown, the containment device 20 is attached to an actuation mechanism 270 via a first conduit 22. The actuation mechanism 270 can be a console, a trigger mechanism, or the like, having a function for fluidly coupling the containment device 20 to components downstream of the actuation mechanism 270, such as one or more actuation components of the first and second containers 30, 40. The actuation mechanism 270 is connected to the first chamber 52 via a second conduit 272, to the first container 30 via a third conduit 274, and to the second container 40 via a fourth conduit 276. The actuation mechanism 270 can include valves, discrete fluid pathways, and / or other actuation devices for controlling the release of fluid to each of the second conduit 272, the third conduit 274, and the fourth conduit 276. The actuation mechanism 270 allows a user to control the amount of propellant fluid released into each of the first chamber 52, the first container 30, and the second container 40. Controlling the propellant fluid allows the user to control the amount of the first and second medicaments released from the distal-most end 50b of the catheter 50, as well as the rate at which the propellant gas is released from the first chamber 52 at the distal-most end 50b. The actuation mechanism 270 may additionally include a processor and a memory having one or more programs stored thereon that may automatically actuate the actuation mechanism 270 to disperse the propellant fluid from the containment device 20 .

[0067] exist Figure 6 , a medical system 310 according to another embodiment is shown. The medical system 310 includes a containment device 20 fluidly coupled to a first container 330 and a second container 340 via first and second conduits 322, 324, respectively. The first container 330 may include a fluid, such as, but not limited to, saline. The second container 340 may include one or more medicaments, such as a powdered medicament or a mixture of powdered medicaments, which can be activated upon contact with a fluid, such as saline or any other medically suitable fluid, stored in the first container 330.

[0068] The first container 330 is fluidly connected to the proximal-most end 350a of the catheter 350 via a third conduit 332. The second container 340 is similarly fluidly connected to the proximal-most end 350a of the catheter 350 via a fourth conduit 342. Both the first and second lumens 352, 354 extend from the proximal-most end 350a of the catheter 350 to the distal-most end 350b, but one or both of the first and second lumens 352, 354 may terminate proximal to the distal-most end 350b. It should be understood that this arrangement is not limited, and the first container 330 may be fluidly coupled to the second lumen 354, while the second lumen 354 may be fluidly coupled to the first lumen 352.

[0069] refer to Figure 7 , showing the Figure 6 FIG3 shows a cross-section of catheter 350 taken along line 7-7. A first lumen 352 is coaxially arranged with a second lumen 354, and is defined by the outermost wall of the second lumen 354 and the outermost wall of catheter 350. As discussed herein, a mixture of fluid and propellant gas from first container 330 can be transported along first lumen 352, and one or more medicaments from second container 340 can be transported along second lumen 354 by the propellant gas. Alternatively, one or more medicaments from second container 340 can be transported along first lumen 352, and the propellant gas and fluid mixture can be transported along second lumen 354. In both configurations, the propellant gas and fluid mixture can aerosolize the one or more medicaments at distal-most end 350b of catheter 350. This interaction can promote mixing of the powdered medicaments, resulting in crosslinking or activation of the one or more medicaments and their propulsion toward the treatment site. This also minimizes cloud formation during application of the powdered medicaments to the target site. Although only one cavity for transferring powdered medicament is shown, i.e. second cavity 354, the present invention is not limited and multiple containers and / or cavities may be used. Additionally, the powdered medicament may be pushed down the cavity of the catheter in any manner described herein.

[0070] Although various medical systems have been described, it should be understood that the specific arrangement of the components in these medical systems is not limiting. Furthermore, the size and shape of the catheter or shaft of the medical system, or the method of dispensing the medical system, are not limiting. As described in the examples herein, agents, such as fluids or powders, are dispensed from the distal end of the catheter, where the agents interact with each other or with another substance to alter one or more of their physical properties. In this manner, therapeutic agents, such as adhesives for limiting bleeding, can be applied endoscopically without obstructing the lumen, passageways, inlets, or outlets of the medical system.

[0071] It will be apparent to those skilled in the art that various modifications and variations can be made to the disclosed device without departing from the scope of the present invention. For example, the container, including the propellant containing device, the shaft and the cavity and / or the configuration of the medicament therein can be modified to provide the desired medical treatment. Other embodiments of the present invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. It is intended that the description and examples be considered merely exemplary, with the true scope and spirit of the invention being indicated by the following claims.

Claims

1. A medical system comprising: a propellant source configured to contain a propellant fluid; a plurality of containers, each of the plurality of containers being configured to contain a material; as well as A shaft, the shaft comprising: a plurality of lumens, each of the plurality of lumens having a first opening at a proximal end of the shaft and a second opening at a distal end of the shaft, wherein the plurality of lumens are fluidly coupled to one or more of the propellant source and at least one of the plurality of containers, and a tip located at a distal-most end of the shaft, the tip comprising: distal opening; a passageway connecting at least one of the plurality of lumens of the shaft to the distal opening; and an auger extending to the distal opening, wherein the auger is rotatably disposed in the passageway and is configured to move material within the passageway toward the distal opening; A first cavity among the plurality of cavities surrounds at least one other cavity among the plurality of cavities, is coaxial therewith, or is arranged side by side therewith. 2 . The medical system of claim 1 , wherein the propellant source is fluidly coupled to each of the plurality of containers and to the first chamber.

3. The medical system of claim 1 or 2, wherein the auger of the tip is configured to mix the contents within the shaft.

4. The medical system of claim 1 or 2, wherein the material in a first container of the plurality of containers is a first medicament, and wherein the material in a second container in the plurality of containers is a second medicament different from the first medicament.

5. The medical system of claim 4, wherein the propellant fluid is a gas configured to mix with the first medicament in the first container and with the second medicament in the second container, and wherein the gas is configured to transport each of the first medicament and the second medicament through a corresponding lumen of the plurality of lumens.

6. The medical system of claim 4, wherein the first medicament and the second medicament are configured to contact each other to form a mixture at or near the distal opening of the shaft, and wherein at least one of the adhesion, viscosity, and therapeutic property of the mixture is greater than the adhesion, viscosity, and therapeutic property of each of the first agent and the second agent, respectively.

7. The medical system of claim 6, wherein the gas from the first chamber is configured to atomize the mixture.

8. The medical system of claim 1 or 2, wherein at least one of the plurality of containers is a syringe, wherein the syringe comprises: a barrel having an inlet at a proximal end of the barrel, an outlet at a distal end of the barrel, and a chamber between the inlet and the outlet; as well as a piston configured to be inserted into the inlet and to move relative to the cylinder, The material in the chamber is configured to be discharged from the outlet by moving the piston toward the outlet.

9. The medical system of claim 1 or 2, wherein each lumen of the plurality of lumens is fluidly isolated from other lumens of the plurality of lumens from the first opening of each lumen to the second opening of each lumen.

10. The medical system of claim 1 , wherein the propellant source is fluidly coupled directly to the first lumen, wherein an inlet of each of the plurality of containers is fluidly coupled to the propellant source, and an outlet of each of the plurality of containers is fluidly coupled to a corresponding lumen of the plurality of lumens at the proximal end of the shaft. 11 . The medical system of claim 10 , wherein the plurality of lumens fluidly coupled to the plurality of containers share a common wall, and wherein the first lumen surrounds the plurality of lumens fluidly coupled to the plurality of containers.

12. The medical system of claim 1 , further comprising an actuator coupled to an outlet of the propellant source, the first chamber, and each of the plurality of containers, wherein the actuator is configured to control the release of the propellant fluid from the propellant source.

13. The medical system of claim 12, wherein the actuator is configured to individually control the release of the propellant fluid to the first chamber and each of the first and second containers of the plurality of containers, and wherein the propellant fluid is configured to aerosolize a mixture of the first and second materials at the distal end of the shaft.

14. The medical system according to claim 1, wherein the propellant source is fluidly coupled directly to an inlet of a first container of the plurality of containers, the first container being configured to contain a liquid, wherein the propellant source is directly fluidly coupled to an inlet of a second container of the plurality of containers, the second container being configured to contain a powder, wherein the propellant fluid is configured to transport the liquid through the first cavity and the powder through a second cavity, the second cavity being fluidly separate from the first cavity, wherein the fluid and the powder are configured to contact each other to form a mixture within the passageway, and wherein at least one of adhesion, viscosity, and therapeutic properties is greater than the adhesion, viscosity, and therapeutic properties of each of the fluid and the powder, respectively.

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