Laser adjustment component for mass spectrometry detection

Abstract

The present invention relates to the field of mass spectrometry detection technology, and in particular to a laser adjustment component for mass spectrometry detection, the structure of which includes: a fixed seat, a support block, a Z-axis positive and negative motion adjustment device, a horizontal motion adjustment device, a Z-axis tilting motion adjustment device, a slide, a laser connecting column, a cover plate, an adjustment frame, and an optical fiber connector, and the support block is installed on the fixed seat. The component of the present invention is simple and easy to adjust, and the component is compact and does not take up too much space. The positive and negative motion of the X, Y, and Z axes of the laser and the Z-axis tilting at a certain angle are achieved through the Z-axis positive and negative motion adjustment device, the horizontal motion adjustment device, and the Z-axis tilting motion adjustment device, which has the function of being suitable for the adjustment requirements of the laser focusing and emission angle, thereby realizing multi-dimensional adjustment of the laser, which is more conducive to the laser decomposition ion source, and the focusing position accuracy and displacement accuracy can also be effectively guaranteed, thereby facilitating the actual debugging of the laser focusing and emission angle by personnel, and improving the excitation and dissociation effect of the sample.

Description

Technical Field

[0001] The present invention relates to the technical field of mass spectrometry detection, and in particular to a laser adjustment component for mass spectrometry detection. Background Art

[0002] Laser mass spectrometry, a new type of soft ionization biomass spectrometry developed in recent years, consists of two main components: a matrix-assisted laser desorption ionization source and a time-of-flight mass analyzer. The basic principle is to disperse the sample in matrix molecules to form crystals. When the crystals are irradiated with laser light, the matrix absorbs energy from the laser, causing charge transfer between the matrix and the sample, and the sample is desorbed and ionized. The ionized sample, under the influence of the electric field, travels in a vacuum and is detected based on the difference in its flight time before reaching the detector.

[0003] Most current laser mass spectrometers use only four screws for laser position adjustment. This approach allows for limited adjustment in a limited number of laser directions, making multi-dimensional adjustment difficult. This is detrimental to laser desorption ionization sources, and the focus position and displacement accuracy cannot be effectively guaranteed. This often results in significant offset of the laser spot from the sample being measured, making it difficult to adjust the spot size appropriately. This forces repeated trial and error to achieve a relatively good focus position. Summary of the Invention

[0004] Other features and advantages of the present invention will be described in the following description, and in part will become apparent from the description, or will be understood by practicing the present invention. The purposes and other advantages of the present invention can be realized and obtained through the structures particularly pointed out in the description, claims, and other drawings of the description.

[0005] The purpose of the present invention is to overcome the above-mentioned shortcomings and provide a laser adjustment component for mass spectrometry detection.

[0006] To achieve the above-mentioned purpose, the technical solution of the present invention is: a laser adjustment component for mass spectrometry detection, whose structure includes: a fixed seat, a support block, a Z-axis positive and negative motion adjustment device, a horizontal motion adjustment device, a Z-axis tilt motion adjustment device, a slide, a laser connecting column, a cover plate, an adjustment frame, and an optical fiber connector. The support block is installed on the fixed seat, the Z-axis positive and negative motion adjustment device is threadedly connected to the support block, the horizontal motion adjustment device is connected to the cover plate, the adjustment frame is connected to the cover plate through the Z-axis tilt motion adjustment device, the adjustment frame is installed on the upper end of the support block, the slide is arranged between the optical fiber connector and the cover plate, the optical fiber connector is fitted into the horizontal motion adjustment device, the laser connecting column is connected to the optical fiber connector, and the horizontal motion adjustment device is supported on the adjustment frame through the Z-axis tilt motion adjustment device.

[0007] Preferably, the horizontal movement adjustment device includes a first stud, a second stud, a first compression spring, an intermediate seat, and an installation cavity. Four equally divided blocks are provided on the intermediate seat. The first stud and the second stud are installed on adjacent equally divided blocks on the intermediate seat. The first stud and the second stud are respectively screwed into the installation cavity through the equally divided blocks to support the optical fiber connector. The optical fiber connector is provided with a first compression spring on the opposite side of the first stud and the second stud. The first compression spring extends into the installation cavity through the equally divided blocks to support the optical fiber connector.

[0008] As a preference, the optical fiber connector is fitted into the mounting cavity, and the intermediate seat is mounted at the lower end of the cover.

[0009] Preferably, the first stud and the second stud are respectively threadedly connected to the equally divided blocks.

[0010] Preferably, the lower end of the intermediate seat is connected to the Z-axis tilt motion adjustment device.

[0011] Preferably, the Z-axis tilt motion adjustment device includes a screw, a second compression spring, a third compression spring, and a threaded groove. The screw passes through the cover and is screwed into the adjustment frame. The adjustment frame is provided with a threaded groove for moving the screw. The second compression spring is sleeved on the screw and connected between the cover and the adjustment frame. The upper end of the third compression spring passes through the adjustment frame and is connected to the middle seat, and the lower end is connected to the Z-axis positive and negative motion adjustment device.

[0012] Preferably, there are four screws in total and they are equally distributed on the cover plate, and the middle seat is supported above the middle part of the adjustment frame by a third compression spring.

[0013] Preferably, the Z-axis positive and negative motion adjustment device includes a threaded cover sleeve, an extension block, a slot, a compression spring sleeve, a fourth compression spring, and a spacer. There are two support blocks in total and both are threadedly connected to the threaded cover sleeve. The extension block is installed on the compression spring sleeve. The extension block is arranged at the lower end of the threaded cover sleeve. The fixed seat is provided with a slot for moving the extension block and the compression spring sleeve. The fourth compression spring is inserted into the compression spring sleeve and pressed against the spacer. A spacer is provided in the compression spring sleeve for separating the fourth compression spring from the third compression spring.

[0014] Preferably, two extension blocks are provided and are connected to the compression spring sleeve in a symmetrical manner.

[0015] Preferably, the upper end of the compression spring sleeve is connected to the adjustment frame.

[0016] By adopting the above technical solution, the beneficial effects of the present invention are as follows: the components of the present invention are simple and easy to adjust, and the components are compact and do not take up too much space. The positive and negative movements of the X, Y, and Z axes of the laser and the Z-axis tilting movement adjustment device are achieved through the Z-axis positive and negative movement adjustment device, the horizontal movement adjustment device, and the Z-axis tilting movement adjustment device, which has the function of being suitable for the adjustment requirements of the laser focus and emission angle, thereby realizing multi-dimensional adjustment of the laser, which is more conducive to the laser decomposition ion source, and the focus position accuracy and displacement accuracy can also be effectively guaranteed, thereby facilitating the actual debugging of the laser focus and emission angle by personnel, and also improving the excitation and dissociation effect of the sample.

[0017] It is to be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the disclosure.

[0018] Undoubtedly, these and other objects of the present invention will become more apparent after the following detailed description of the preferred embodiment is described with reference to the various figures and drawings.

[0019] In order to make the above-mentioned beneficial effects and other purposes, features and advantages of the present invention more obvious and easy to understand, one or several preferred embodiments are given below and described in detail with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention but do not constitute a limitation of the present invention.

[0021] In the drawings, like components are given like reference numerals, and the drawings are schematic and not necessarily drawn to scale.

[0022] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only one or several embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on such drawings without paying any creative work.

[0023] Figure 1 This is a schematic structural diagram of a laser adjustment component for mass spectrometry detection according to the present invention;

[0024] Figure 2 This is a schematic diagram of the structure of a laser adjustment assembly for mass spectrometry detection according to the present invention when viewed from above;

[0025] Figure 3 This is a schematic diagram of the exploded structure of the horizontal motion regulating device of the present invention;

[0026] Figure 4Schematic diagram of the structure of the horizontal motion regulating device of the present invention;

[0027] Figure 5 Schematic diagram of the structure of the Z-axis tilt motion adjustment device of the present invention;

[0028] Figure 6 Schematic diagram of the cross-sectional structure of the Z-axis tilt motion adjustment device of the present invention;

[0029] Figure 7 This is a schematic diagram of the exploded structure of the Z-axis positive and negative motion adjustment device of the present invention;

[0030] Figure 8 Schematic diagram of the exploded bottom view of the structure of the Z-axis positive and negative motion adjustment device of the present invention;

[0031] Figure 9 It is a structural schematic diagram of the compression spring sleeve of the present invention;

[0032] Figure 10 It is a schematic diagram of the cross-sectional structure of the compression spring sleeve of the present invention.

[0033] Explanation of the main figure marks: fixed seat-1, support block-2, Z-axis positive and negative motion adjustment device-3, horizontal motion adjustment device-4, Z-axis tilt motion adjustment device-5, slide-6, laser connecting column-7, cover plate-8, adjustment frame-9, optical fiber connector-10, threaded cover sleeve-301, extension block-302, slot-303, compression spring sleeve-304, fourth compression spring-305, spacer-306, first stud-401, second stud-402, first compression spring-403, intermediate seat-404, mounting cavity-405, screw-501, second compression spring-502, third compression spring-503, threaded groove-504. DETAILED DESCRIPTION

[0034] The following describes the embodiments of the present invention in detail with reference to the accompanying drawings and examples, so that the present invention can fully understand how to apply technical means to solve technical problems and achieve technical effects, and thus implement the invention accordingly. It should be noted that, as long as no conflict exists, the various embodiments of the present invention and the various features of the embodiments can be combined with each other, and the resulting technical solutions are all within the scope of protection of the present invention.

[0035] Meanwhile, in the following description, many specific details are set forth for the purpose of explanation to provide a thorough understanding of the embodiments of the present invention. However, it will be apparent to those skilled in the art that the present invention may be implemented without the specific details or the particular manner described herein.

[0036] See also Figure 1-3The present invention provides a laser adjustment component for mass spectrometry detection, which structure includes: a fixed base 1, a support block 2, a Z-axis positive and negative motion adjustment device 3, a horizontal motion adjustment device 4, a Z-axis tilt motion adjustment device 5, a slide 6, a laser connecting column 7, a cover plate 8, an adjustment frame 9, and an optical fiber connector 10. The support block 2 is installed on the fixed base 1, the Z-axis positive and negative motion adjustment device 3 is threadedly connected to the support block 2, the horizontal motion adjustment device 4 is connected to the cover plate 8, the adjustment frame 9 is connected to the cover plate 8 through the Z-axis tilt motion adjustment device 5, the adjustment frame 9 is installed on the upper end of the support block 2, the slide 6 is arranged between the optical fiber connector 10 and the cover plate 8, the optical fiber connector 10 is fitted into the horizontal motion adjustment device 4, the laser connecting column 7 is connected to the optical fiber connector 10, and the horizontal motion adjustment device 4 is supported on the adjustment frame 9 through the Z-axis tilt motion adjustment device 5. The laser's fiber optic connector is connected to the laser connection column 7, which is then connected to the laser. The Z-axis positive and negative motion adjustment device 3 controls the adjustment frame 9 to perform lifting and adjustment movements, allowing the Z-axis tilting motion adjustment device 5 to lift and lower the horizontal motion adjustment device 4, resulting in the fiber optic connector 10 and the laser connection column 7 being able to lift and lower the laser. The horizontal motion adjustment device 4 pushes the fiber optic connector 10 forward, backward, left, and right as needed, allowing the laser connection column 7 to perform positive and negative movements along the X and Y axes. By rotating the Z-axis tilting motion adjustment device 5, the horizontal motion adjustment device 4 is squeezed, causing the horizontal motion adjustment device 4 to tilt the fiber optic connector 10, driving the laser to form different tilt angles. This assembly can achieve positive and negative movements along the X, Y, and Z axes, as well as a certain angle of Z-axis tilt, and is suitable for adjusting the laser focus and emission angle.

[0037] See also Figure 3 and Figure 4The horizontal motion adjustment device 4 includes a first stud 401, a second stud 402, a first compression spring 403, an intermediate seat 404, and an installation cavity 405. Four equally divided blocks are provided on the intermediate seat 404. The first stud 401 and the second stud 402 are installed on the adjacent equally divided blocks on the intermediate seat 404. The first stud 401 and the second stud 402 are respectively screwed into the installation cavity 405 through the equally divided blocks to support the optical fiber connector 10. The optical fiber connector 10 is provided with a first compression spring 403 on the opposite side of the first stud 401 and the second stud 402. The first compression spring 403 extends into the installation cavity 405 through the equally divided blocks to support the optical fiber connector 10. The optical fiber connector 10 is fitted into the installation cavity 405. The intermediate seat 404 is installed at the lower end of the cover plate 8. The first stud 401 and the second stud 402 are respectively threadedly connected to the equally divided blocks. The lower end of the intermediate seat 404 is connected to the Z-axis tilt motion adjustment device 5. By rotating the first stud 401 or the second stud 402, the optical fiber connector 10 will be pushed under the action of the intermediate seat 404, squeezing the first compression spring 403 to obtain a reaction force, thereby adjusting the forward and reverse rotation of each stud to realize the positive and negative movement of the optical fiber connector 10 on the X axis and Y axis in the installation cavity 405, thereby facilitating the adjustment of the focus of the laser X axis and Y axis.

[0038] See also Figure 5 and Figure 6 The Z-axis tilt motion adjustment device 5 includes a screw 501, a second compression spring 502, a third compression spring 503, and a threaded groove 504. The screw 501 passes through the cover 8 and is screwed into the adjustment frame 9. The adjustment frame 9 is provided with a threaded groove 504 for moving the screw 501. The second compression spring 502 is sleeved on the screw 501 and connected between the cover 8 and the adjustment frame 9. The upper end of the third compression spring 503 passes through the adjustment frame 9 and is connected to the middle seat 404, and the lower end is connected to the Z-axis positive and negative motion adjustment device 3. There are four screws 501 in total and they are equally divided on the cover 8. The middle seat 404 is supported above the middle part of the adjustment frame 9 by the third compression spring 503. The four screws 501 are rotated as required, and the screws 501 move up and down under the action of the thread groove 504, and the second compression spring 502 is deformed, thereby squeezing the cover plate 8 to tilt downward or upward, and the third compression spring 503 is also deformed, thereby causing the middle seat 404 to tilt downward or upward, and the optical fiber connector 10 follows to form different inclination angles. By making the locking heights of the four screws 501 different (that is, the compression heights of the four second compression springs (502) are different), the emission angle of the laser can be adjusted.

[0039] Please refer to 7-10. The Z-axis positive and negative motion adjustment device 3 includes a threaded cover sleeve 301, an extension block 302, a slot 303, a compression spring sleeve 304, a fourth compression spring 305, and a spacer 306. There are two support blocks 2 and both are threadedly connected to the threaded cover sleeve 301. The extension block 302 is installed on the compression spring sleeve 304. The extension block 302 is set at the lower end of the threaded cover sleeve 301. The fixed seat 1 is provided with a slot 303 for moving the extension block 302 and the compression spring sleeve 304. The fourth compression spring 305 is inserted into the compression spring sleeve 304 and is pressed against the spacer 306. The compression spring sleeve 304 is provided with a spacer 306 for separating the fourth compression spring 305 from the third compression spring 503. There are two extension blocks 302 and are connected to the compression spring sleeve 304 in a symmetrical manner. The upper end of the compression spring sleeve 304 is connected to the adjustment frame 9. By rotating the threaded cover sleeve 301, the threaded cover sleeve 301 moves up and down under the action of the support block 2. During the movement, the extension block 302 will be squeezed or released. The fourth compression spring 305 is deformed with the pressure of the threaded cover sleeve 301, so that the compression spring sleeve 304 moves up and down (positive and negative movement of the Z axis), thereby moving the adjustment frame 9 and the intermediate seat 404 up and down, thereby facilitating the adjustment of the focus of the laser Z axis.

[0040] During use, the laser's optical fiber connector is connected to the laser connection column 7, and then connected to the laser. When the laser focus and emission angle need to be adjusted, by rotating the first stud 401 or the second stud 402, the optical fiber connector 10 will be pushed under the action of the intermediate seat 404, squeezing the first compression spring 403 to obtain a reaction force, thereby adjusting the forward and reverse rotation of each stud to achieve positive and negative movement of the optical fiber connector 10 in the installation cavity 405 along the X and Y axes, thereby facilitating the adjustment of the laser's X and Y axis focus. By rotating the threaded cover 301, the threaded cover 301 moves up and down under the action of the support block 2, squeezing or releasing the extension block 302 during movement. The fourth compression spring 305 deforms with the pressure of the threaded cover 301, causing the compression spring cover 304 to move up and down (positive and negative movement along the Z axis), thereby moving the adjustment frame 9 and the intermediate seat 404 up and down, thereby facilitating the adjustment of the laser's Z axis focus. By rotating the four screws 501 as needed, the screws 501 move up and down under the action of the thread groove 504, causing the second compression spring 502 to deform, squeezing the cover plate 8 and causing it to tilt downward or upward. The third compression spring 503 also deforms, causing the intermediate seat 404 to tilt downward or upward, and the optical fiber connector 10 to follow suit, forming different inclination angles. By varying the locking heights of the four screws 501 (i.e., the compression heights of the four second compression springs 502), the laser emission angle can be adjusted. This assembly can achieve positive and negative movement in the X, Y, and Z axes, as well as a certain angle of Z-axis tilt, which is suitable for adjusting the laser focus and emission angle.

[0041] It should be understood that the embodiments disclosed herein are not limited to the specific processing steps or materials disclosed herein, but should extend to equivalent substitutions of such features understood by those skilled in the relevant art. It should also be understood that the terminology used herein is for the purpose of describing specific embodiments only and is not intended to be limiting.

[0042] The "embodiment" mentioned in the specification means that a particular feature or characteristic described in conjunction with the embodiment is included in at least one embodiment of the present invention. Therefore, the phrase or "embodiment" appearing in various places throughout the specification does not necessarily refer to the same embodiment.

[0043] Furthermore, the described features or characteristics may be combined in any other suitable manner into one or more embodiments. In the above description, some specific details, such as thickness, quantity, etc., are provided to provide a comprehensive understanding of the embodiments of the present invention. However, those skilled in the relevant art will appreciate that the present invention may be implemented without one or more of the above specific details or may be implemented using other methods, components, materials, etc.

Claims

1. A laser adjustment component for mass spectrometry detection, characterized in that: Its structure includes: a fixed seat (1), a support block (2), a Z-axis positive and negative motion adjustment device (3), a horizontal motion adjustment device (4), a Z-axis tilt motion adjustment device (5), a slide (6), a laser connecting column (7), a cover plate (8), an adjustment frame (9), and an optical fiber connector (10), wherein the support block (2) is installed on the fixed seat (1), the Z-axis positive and negative motion adjustment device (3) is threadedly connected to the support block (2), the horizontal motion adjustment device (4) is connected to the cover plate (8), the adjustment frame (9) is connected to the cover plate (8) through the Z-axis tilt motion adjustment device (5), the adjustment frame (9) is installed on the upper end of the support block (2), the slide (6) is arranged between the optical fiber connector (10) and the cover plate (8), the optical fiber connector (10) is fitted into the horizontal motion adjustment device (4), the laser connecting column (7) is connected to the optical fiber connector (10), and the horizontal motion adjustment device (4) is supported on the adjustment frame (9) through the Z-axis tilt motion adjustment device (5); The horizontal motion adjustment device (4) includes a first stud (401), a second stud (402), a first compression spring (403), an intermediate seat (404), and an installation cavity (405). The intermediate seat (404) is provided with four equal blocks. The first stud (401) and the second stud (402) are installed on adjacent equal blocks on the intermediate seat (404). The first stud (401) and the second stud (402) are respectively screwed into the installation cavity (405) through the equal blocks to support the optical fiber connector (10). The optical fiber connector (10 ) is provided with a first compression spring (403) on the opposite side of the first stud (401) and the second stud (402), the first compression spring (403) extends into the installation cavity (405) through the equal-division block to support the optical fiber connector (10), the optical fiber connector (10) is fitted into the installation cavity (405), the middle seat (404) is installed at the lower end of the cover plate (8), the first stud (401) and the second stud (402) are respectively threadedly connected to the equal-division block, and the lower end of the middle seat (404) is connected to the Z-axis tilt motion adjustment device (5); The Z-axis tilt motion adjustment device (5) comprises a screw (501), a second compression spring (502), a third compression spring (503), and a threaded groove (504); the screw (501) passes through the cover plate (8) and is screwed into the adjustment frame (9); the adjustment frame (9) is provided with a threaded groove (504) for moving the screw (501); the second compression spring (502) is sleeved on the screw (501) and connected between the cover plate (8) and the adjustment frame (9); the upper end of the third compression spring (503) passes through the adjustment frame (9) and is connected to the middle seat (404); and the lower end is connected to the Z-axis positive and negative motion adjustment device (3); The Z-axis positive and negative motion adjustment device (3) comprises a threaded cover sleeve (301), an extension block (302), a slot (303), a compression spring sleeve (304), a fourth compression spring (305), and a spacer (306). Two support blocks (2) are provided and both are threadedly connected to the threaded cover sleeve (301). The extension block (302) is mounted on the compression spring sleeve (304). The extension block (302) is arranged at the lower end of the threaded cover sleeve (301). The fixed seat (1) is provided with a slot (303) for moving the extension block (302) and the compression spring sleeve (304). The fourth compression spring (305) is inserted into the compression spring sleeve (304) and pressed against the spacer (306). The compression spring sleeve (304) is provided with a spacer (306) for separating the fourth compression spring (305) and the third compression spring (503).

2. The laser adjustment assembly for mass spectrometry detection according to claim 1, characterized in that: There are four screws (501) in total and they are equally distributed on the cover plate (8). The middle seat (404) is supported above the middle of the adjustment frame (9) by a third compression spring (503).

3. The laser adjustment assembly for mass spectrometry detection according to claim 1, characterized in that: There are two extension blocks (302) in total and they are connected to the compression spring sleeve (304) in a symmetrical manner.

4. The laser adjustment assembly for mass spectrometry detection according to claim 1, characterized in that: The upper end of the compression spring sleeve (304) is connected to the adjustment frame (9).

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