Valve clip control handle, delivery device and valve repair system

Abstract

The present invention relates to a valve clip control handle, a delivery device and a valve repair system. The valve clip control handle includes a housing, an actuating wire and an actuating wire control mechanism. The actuating wire is partially located in the housing, and the distal end of the actuating wire can be threadedly connected to a valve clip coupler through a sheath tube. The actuating wire control mechanism includes a wire pressing assembly, a driving knob and an unloading knob. The wire pressing assembly is slidably disposed in the housing and connected to the actuating wire. The wire pressing assembly is configured to be able to move synchronously with the actuating wire under a first working condition. The driving knob abuts against the proximal end of the wire pressing assembly and is threadedly connected to the housing. The driving knob can push the wire pressing assembly and the actuating wire to move so as to drive the clamping arms to open and close. The unloading knob abuts against the proximal end of the driving knob and is connected to the actuating wire. The unloading knob is configured to be able to move synchronously with the actuating wire under a first working condition and be able to drive the actuating wire to rotate to dissociate from the valve clip coupler under a second working condition. The valve clip control handle proposed by the present invention has a compact structure and is convenient to operate.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and particularly relates to a valve clip control handle, a delivery device and a valve repair system. Background Art

[0002] The heart valve refers to the valve between the atrium and the ventricle or between the ventricle and the artery. Among them, the atrioventricular valve includes the mitral valve and the tricuspid valve. The mitral valve is two valves attached to the periphery of the left atrioventricular orifice, connected to the papillary muscle by chordae tendineae, and has the function of preventing the blood in the left ventricle from flowing back into the left atrium. Mitral regurgitation is due to organic or functional changes in the mitral leaflets and their related structures, resulting in poor anastomosis of the anterior and posterior mitral leaflets. When mitral regurgitation occurs, the blood flow will flow back from the left ventricle to the left atrium, causing a series of pathophysiological changes.

[0003] Surgical valve repair or replacement is considered the standard treatment for such diseases. However, surgery has the disadvantages of large trauma, obvious postoperative pain, slow recovery, and high risk. In recent years, the interventional treatment of heart valve disease has developed rapidly due to its advantages of small trauma, relatively safe, and good curative effect. Among them, the valve repair method developed based on the principle of surgical edge-to-edge suture technology of the valve has been affirmed due to its high safety, simple technical principle, and high feasibility. During this operation, the operator needs to use a delivery device to deliver the valve clip applicator into the patient's body. The valve clip control handle in the delivery device is used to control the valve clip applicator. In the related technology, the structure of the valve clip control handle is complex and the operation steps are cumbersome, which affects the surgical efficiency. Summary of the Invention

[0004] The purpose of the present invention is to at least solve the problem of cumbersome operation steps of the valve clip control handle. This purpose is achieved by the following technical solutions:

[0005] The first aspect of the present invention provides a valve clip control handle for controlling a valve clip applicator. The valve clip applicator includes a plurality of relatively opening and closing clamping arms. The valve clip control handle includes a housing, an actuating wire, and an actuating wire control mechanism. The actuating wire is partially located in the housing, and the distal end of the actuating wire can be threadedly connected to the valve clip applicator through a sheath tube. The actuating wire control mechanism includes a wire pressing assembly, a driving knob, and an unloading knob. The wire pressing assembly is slidably disposed in the housing and connected to the actuating wire. The wire pressing assembly is configured to be able to move synchronously with the actuating wire under a first working condition; the driving knob abuts against the proximal end of the wire pressing assembly and is threadedly connected to the housing. The driving knob can push the wire pressing assembly and the actuating wire to move, so as to drive the clamping arms to open and close; the unloading knob abuts against the proximal end of the driving knob and is connected to the actuating wire. The unloading knob is configured to be able to move synchronously with the actuating wire under the first working condition and be able to drive the actuating wire to rotate to dissociate from the valve clip applicator under a second working condition.

[0006] In the valve clip control handle proposed by the embodiment of the present invention, the wire pressing assembly, the driving knob, and the unloading knob cooperate with each other and can be linked under the first working condition. The operator only needs to rotate the driving knob to control the movement of the actuating wire, and then the clamping arms in the valve clip can be opened and closed; after the wire pressing assembly is adjusted to the second working condition, the operator only needs to rotate the unloading knob to control the rotation of the actuating wire, and then the actuating wire can be dissociated from the valve clip. There is no need to use external tools to control the actuating wire. In this embodiment, the function integration degree of the actuating wire control mechanism is high, making the valve clip control handle not only compact in structure but also convenient to operate, solving the problem of cumbersome operation steps of the valve clip control handle and improving the surgical efficiency.

[0007] In addition, the valve clip control handle proposed by the embodiment of the present invention may also have the following technical features:

[0008] In some embodiments of the present invention, the wire pressing assembly includes a wire pressing column and a limiting block. The actuating wire is arranged in the wire pressing column. The limiting block is detachably connected to the wire pressing column and is at least partially located on the proximal side of the wire pressing column. The limiting block can prevent the wire pressing column from rotating under the condition of being connected to the wire pressing column.

[0009] In some embodiments of the present invention, the wire pressing assembly further includes a hand-tightening screw. The hand-tightening screw is inserted into the limiting block and is detachably connected to the wire pressing column. The end of the hand-tightening screw is exposed outside the housing.

[0010] In some embodiments of the present invention, the actuating wire control mechanism further includes a wire passing tube. The wire passing tube extends distally from inside the wire pressing column and can penetrate into the sheath tube. Part of the actuating wire is arranged in the wire passing tube.

[0011] In some embodiments of the present invention, the wire pressing column is axially provided with a first through hole and at least one first locking hole communicating with the first through hole in the radial direction. The first locking hole is used to install a fastener to lock the actuating wire and / or the wire passing tube located in the first through hole.

[0012] In some embodiments of the present invention, the valve clip control handle further includes a bearing. The driving knob and the unloading knob are respectively matched with the bearing.

[0013] In some embodiments of the present invention, the driving knob includes a threaded rod and a rotating head connected to each other. The bearing is arranged inside the rotating head. The unloading knob is partially inserted into the rotating head and is matched with the bearing.

[0014] In some embodiments of the present invention, the unloading knob is axially provided with a second through hole and radially provided with one or more second locking holes for installing fasteners to lock the actuating wire located in the second through hole.

[0015] A second aspect of the present invention provides a delivery device, which includes a sheath tube, an adjustable bending sheath, a sheath tube bending control handle, and a valve clip control handle according to any one of the above embodiments. The adjustable bending sheath is connected to the sheath tube bending control handle, the sheath tube is movably inserted into the adjustable bending sheath, and the proximal end of the sheath tube is connected to the valve clip control handle.

[0016] The delivery device provided by the embodiments of the present invention has the same advantages as the valve clip control handle provided by any one of the above embodiments, and will not be described in detail herein.

[0017] A third aspect of the present invention provides a valve repair system, which includes a valve clip applicator and a delivery device according to any one of the above embodiments. The sheath tube of the delivery device is detachably connected to the valve clip applicator to deliver the valve clip applicator.

[0018] The valve repair system provided by the embodiments of the present invention has the same advantages as the valve clip control handle and the delivery device provided by any one of the above embodiments, and will not be described in detail herein. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The following briefly introduces the drawings in the embodiments. Those skilled in the art can also obtain other drawings based on these drawings without creative efforts.

[0020] Figure 1 It is a schematic structural diagram of the valve repair system;

[0021] Figure 2 It is a schematic structural diagram of the valve clip applicator in the valve repair system;

[0022] Figure 3 It is a schematic structural diagram of a kind of valve clip control handle;

[0023] Figure 4 It is a schematic internal structure diagram of the valve clip control handle;

[0024] Figure 5 It is for Figure 4 the top view of;

[0025] Figure 6 It is an exploded view of the actuating wire control mechanism in the valve clip control handle;

[0026] Figure 7 It is an exploded view of the pulling wire control mechanism in the valve clip control handle;

[0027] Figure 8 Partial explosion view of the valve clip control handle;

[0028] Figure 9 Schematic diagram showing the opening of the clamping arm and the opening of the capture arm of the valve clip actuator controlled by the valve clip control handle;

[0029] Figure 10 Schematic diagram showing the closing of the clamping arm and the capture of the capture arm of the valve clip actuator controlled by the valve clip control handle;

[0030] Figure 11 Schematic diagram when the valve clip control handle is disengaged from the valve clip actuator. Specific embodiments

[0031] The following will describe in conjunction with the drawings in the embodiments of the present invention. The terms used herein are only for the purpose of describing specific exemplary embodiments and should not be construed as limiting the present invention. For example, the terms "comprising" and "having" not only indicate the presence of the stated features, but also do not exclude the presence of other features; the terms "first" and "second" do not imply order or sequence; the terms "inner", "outer", "above", and "below" are only for facilitating the description of the relationship of one feature shown in the drawings relative to another feature and do not indicate that it must have a specific orientation. It should be noted that in the field of interventional medical devices, the proximal end refers to the end closer to the operator, and the distal end refers to the end farther from the operator; the axial direction refers to the direction parallel to the line connecting the centers of the distal end and the proximal end of the medical device in the natural state. In the description of the present invention, the above definitions are only for convenience of expression and should not be construed as limiting the present invention.

[0032] Please refer to Figures 1 to 5 , an embodiment of the first aspect of the present invention provides a valve clip control handle 100, and an embodiment of the second aspect of the present invention provides a delivery device 1100. The delivery device 1100 can be applied to the valve repair system 1000 proposed in the embodiment of the third aspect of the present invention. As Figure 1 shown, in the valve repair system 1000, the delivery device 1100 is used to deliver the valve clip actuator 1200 into the patient's body, for example, through a minimally invasive access on the body surface and blood vessels to a designated position to achieve the repair treatment of heart valves (including but not limited to mitral valve, tricuspid valve, aortic valve, pulmonary valve). The valve clip control handle 100 in the delivery device 1100 is used to control the operation of the valve clip actuator 1200, such as capture, clamping, etc.

[0033] Exemplarily, please refer to Figure 2, the valve clip applier 1200 includes a sliding member 1203, a plurality of relatively opening and closing clip arms 1201, and a plurality of capture arms 1202. When the sliding member 1203 slides axially, the clip arms 1201 directly connected thereto or indirectly connected through an intermediate structure rotate to open or close, thereby clamping the valve. For example, when the valve clip applier 1200 is applied to mitral valve repair, the number of clip arms 1201 and capture arms 1202 can both be set to two. The two capture arms 1202 are used to capture the valve, and the two clip arms 1201 are used to clamp the captured valve, so as to achieve edge-to-edge repair of the mitral valve. On this basis, the valve clip control handle 100 proposed in this embodiment is connected to the valve clip applier 1200 through a sheath 1130. The valve clip applier 1200 is connected to the distal end of the sheath 1130, and the valve clip control handle 100 is connected to the proximal end of the sheath 1130.

[0034] Please continue to refer to Figure 1 , Figures 2 to 5 , and in combination with reference to Figures 6 to 8 , the valve clip control handle 100 proposed in this embodiment includes a housing 10, an actuating wire 20, an actuating wire control mechanism 30, a pulling wire 40, and a pulling wire control mechanism 50. A sheath channel 11 matching with the sheath 1130 is provided at the distal end of the housing 10; the actuating wire 20 is axially movably arranged in the housing 10, and the distal end of the actuating wire 20 can pass through the sheath 1130 and be threadedly connected to the valve clip applier 1200; the actuating wire control mechanism 30 is connected to the actuating wire 20, and the actuating wire control mechanism 30 is configured to drive the actuating wire 20 to move in one working condition so that the clip arms 1201 open and close, and drive the actuating wire 20 to rotate in another working condition to disengage from the valve clip applier 1200; the pulling wire 40 can pass through the sheath 1130 and be connected to the capture arms 1202; the pulling wire control mechanism 50 is connected to the pulling wire 40, and the pulling wire control mechanism 50 is configured to lock and pull the pulling wire 40 in one working condition so that the capture arms 1202 open and close, and drive the pulling wire 40 to disengage from the valve clip applier 1200 in another working condition.

[0035] In the valve clamp control handle 100 proposed in this embodiment, the actuator wire control mechanism 30 can be adjusted to different working conditions to control the movement or rotation of the actuator wire 20, so as to realize the control of the opening and closing action of the clamp arm 1201 in the valve clamp 1200, and the control of the disengagement action of the actuator wire 20 and the valve clamp 1200, thereby improving the functional integration of the actuator wire control mechanism 30; by setting a pull wire control mechanism 50 to drive the pull wire 40, it is possible to realize the control of the capturing action of the capturing arm 1202 in the valve clamp 1200, and the control of the disengagement action of the pull wire 40 and the valve clamp 1200, thereby improving the functional integration of the pull wire control mechanism 50, thereby making the valve clamp control handle 100 realize the control of the entire working process of the valve clamp 1200 on the basis of a compact structure, facilitating the operation of the operator, solving the problem of complicated operating steps of the valve clamp control handle 100, and improving the surgical efficiency.

[0036] Please continue reading Figure 6 , and refer to Figures 3 to 5 The housing 10 in the valve clip control handle 100 is used to install the actuating wire control mechanism 30, the pulling wire control mechanism 50 and the connecting sheath 1130. The housing 10 can be formed by three-dimensional printing or injection molding. In some embodiments of the present invention, for example Figure 6 As shown, the shell 10 includes a bottom shell 102 and a top cover 101. The bottom shell 102 is snap-fitted with the top cover 101 and connected by fasteners such as screws or bolts. In addition, a sleeve can also be connected to the far end of the shell 10 to improve the reliability of the connection between the bottom shell 102 and the top cover 101.

[0037] Furthermore, if Figure 4 and Figure 6 As shown, the valve clamp control handle 100 also includes a sheath fixing assembly 60, which is disposed in the shell 10 and is located near the distal end of the shell 10. In this embodiment, the proximal end of the sheath 1130 is penetrated into the shell 10 and connected to the sheath fixing assembly 60. The sheath fixing assembly 60 is connected to the shell 10. For example, the sheath fixing assembly 60 can be connected to the shell 10 by a screw, thereby preventing the sheath 1130 from moving, that is, preventing the sheath 1130 from moving or rotating relative to the shell 10, so that the proximal end of the sheath 1130 is fixed in the shell 10 and remains stable.

[0038] Further, the sheath fixing assembly 60 may include two pressure rings 61 arranged opposite to each other, the two pressure rings 61 are buckled and connected to hold the sheath 1130 tightly. For example, the two pressure rings 61 have the same structure, such as Figure 6As shown, the cross-sectional shape of the part where the pressing ring 61 holds the sheath tube 1130 is arc-shaped or semi-circular. Connecting plates are extended on both sides of the pressing ring 61. When the two pressing rings 61 are snap-connected, the connecting plates on the same side of the two pressing rings 61 are aligned and abutted. On this basis, the two connecting plates can be connected by welding, or fasteners such as screws are used to pass through the two connecting plates to connect the two pressing rings 61 and hold the sheath tube 1130.

[0039] On the basis of the above embodiment, as Figure 6 shown, a receiving cavity 12 for installing the sheath tube fixing assembly 60 is provided in the housing 10. The receiving cavity 12 is located at the proximal end of the sheath tube channel 11 and communicates with the sheath tube channel 11. Taking the sheath tube fixing assembly 60 including two pressing rings 61 and the housing 10 including a bottom shell 102 and a top cover 101 as an example, grooves are respectively provided on the bottom shell 102 and the top cover 101. After the two grooves are aligned, the above-mentioned receiving cavity 12 is formed. On the basis of the two pressing rings 61 being connected, they can also be connected to at least one of the bottom shell 102 and the top cover 101 by fasteners such as screws, thereby further improving the connection reliability between the sheath tube fixing assembly 60, the sheath tube 1130, and the housing 10.

[0040] Furthermore, as Figures 4 to 6 shown, a sealing cavity 14 is provided in the housing 10. The sealing cavity 14 is located on the proximal side of the receiving cavity 12 and communicates with the receiving cavity 12, so that the proximal end of the sheath tube 1130 can extend into the sealing cavity 14. In this embodiment, the sealing cavity 14 is formed by surrounding with a sealing ring 80. Exemplarily, corresponding annular grooves are respectively provided on the opposite sides of the bottom shell 102 and the top cover 101. The sealing ring 80 is matched with the two annular grooves, and the sealing ring 80 can be a rubber ring or the like. In addition, one or two exhaust ports 17 are provided on the housing 10. The exhaust ports 17 communicate with the sealing cavity 14, and an exhaust valve (not shown in the figure) is connected to the exhaust ports 17.

[0041] Please continue to refer to Figures 1 to 6 and, in combination with referring to Figure 7 , the distal end of the actuating wire 20 in the valve clip control handle 100 is connected to the valve clip 1200. On the basis of the above embodiment, the actuating wire 20 is connected to the sliding member 1203 of the valve clip 1200, and is used to drive the sliding member 1203 to slide axially, thereby driving the clamping arms 1201 to open and close. As Figure 7As shown, the actuating wire 20 is axially arranged, partially located in the housing 10. The part of the actuating wire 20 near the distal end of the housing 10 extends into the sheath 1130 and extends in the sheath 1130 to be connected to the sliding member 1203 of the valve clip 1200. In this embodiment, the actuating wire 20 is threadedly connected to the sliding member 1203. For example, the distal end of the actuating wire 20 is provided with an external thread section 21, so as to cooperate with the threaded hole in the sliding member 1203. The threaded connection method can ensure the stability when the actuating wire 20 drives the sliding member 1203 to move axially, and is convenient for the operator to dissociate the actuating wire 20 from the valve clip 1200 by rotating the actuating wire 20. It should be noted that in this embodiment, dissociation means the disconnection between the two. Further, the actuating wire 20 can be set as a shape memory alloy wire, such as a nitinol wire.

[0042] Further, according to the above embodiment, as Figure 6 shown, a guiding hole 15 is further provided in the sealing cavity 14. Exemplarily, semi-circular grooves are respectively provided on the opposite sides of the top cover 101 and the bottom shell 102, and the two semi-circular grooves are combined to form the guiding hole 15. In this embodiment, the guiding hole 15 can cooperate with the actuating wire 20 to limit the actuating wire 20 and provide guidance for the actuating wire 20 to prevent the actuating wire 20 from bending in the sealing cavity 14.

[0043] According to the above embodiment, the actuating wire 20 is connected to the actuating wire control mechanism 30, and the operator can control the movement of the actuating wire 20 by operating the actuating wire control mechanism 30. Please refer to Figure 7 , in some embodiments of the present invention, the actuating wire control mechanism 30 includes a wire pressing assembly 31, a driving knob 32 and a unloading knob 33 arranged in sequence from the distal end to the proximal end, and the actuating wire 20 is threaded through the above components. The wire pressing assembly 31 is slidably arranged in the housing 10 and is connected to the actuating wire 20 threaded therein. The wire pressing assembly 31 is used to press the actuating wire 20. The driving knob 32 abuts against the proximal end of the wire pressing assembly 31 and is threadedly connected to the housing 10. The driving knob 32 is used to drive the actuating wire 20 to move. The unloading knob 33 is located on the proximal side of the driving knob 32 and is connected to the actuating wire 20 threaded therein. The unloading knob 33 is used to drive the actuating wire 20 to rotate.

[0044] On the basis of the above embodiment, as Figures 4 to 6 shown, the housing 10 is provided with a first sliding hole 13 inward from the proximal end. The first sliding hole 13 is located on the proximal side of the sealing cavity 14. The wire pressing assembly 31 is at least partially slidably arranged in the first sliding hole 13. Taking the housing 10 including the top cover 101 and the bottom shell 102 as an example, grooves are respectively provided on the opposite sides of the top cover 101 and the bottom shell 102, and the two grooves are buckled to form the first sliding hole 13.

[0045] In this embodiment, the wire pressing assembly 31 includes a wire pressing column 311. The wire pressing column 311 is arranged in the first sliding hole 13 and can rotate and slide in the first sliding hole 13. As Figure 7 shown, a first through hole 3111 is axially arranged in the wire pressing column 311, and the actuating wire 20 is threaded through the first through hole 3111. Further, at least one first locking hole 3112 is radially arranged in the wire pressing column 311. The first locking hole 3112 communicates with the first through hole 3111. The first locking hole 3112 is used for installing fasteners such as bolts or studs. The actuating wire 20 in the first through hole 3111 is locked by the pressing method of the fasteners. Thus, the actuating wire 20 and the wire pressing column 311 are relatively fixed, and the actuating wire 20 can move or rotate synchronously with the wire pressing column 311.

[0046] Taking the fastener being set as a stud as an example, in an alternative embodiment, the first locking hole 3112 is set as a blind hole, which is opened inward from the side wall of the wire pressing column 311 until it penetrates through the first through hole 3111. The inner wall of the blind hole is provided with internal threads, and the stud is matched with the internal threads. The bottom end of the stud abuts against the inner side wall of the first through hole 3111, so as to press the actuating wire 20 threaded in the first through hole 3111. In another alternative embodiment, the first locking hole 3112 is set as a through hole. The first locking hole 3112 is divided into two sections by the first through hole 3111. The hole section matched with the stud is a threaded hole section, and the other section is set as a light hole section. Further, the inner diameter of the light hole section can be larger than that of the threaded hole section. Thus, the bottom of the stud extends into the light hole section, and the actuating wire 20 located at the penetration of the first through hole 3111 and the first locking hole 3112 is pressed into a bent shape, further improving the connection reliability between the actuating wire 20 and the wire pressing column 311.

[0047] In this embodiment, the driving knob 32 is axially provided with a through hole, and the actuating wire 20 is slidably arranged in the through hole. The driving knob 32 includes a threaded rod 321 and a rotating head 322 which are connected. The threaded rod 321 and the rotating head 322 can be set as an integrally formed structure. The driving knob 32 is threadedly connected to the proximal end of the first sliding hole 13. Among them, the rotating head 322 is located outside the housing 10, and the threaded rod 321 is threadedly connected in the first sliding hole 13. When the driving knob 32 rotates relative to the housing 10, the threaded rod 321 moves axially in the first sliding hole 13, so as to push the wire pressing assembly 31 and the actuating wire 20 to move axially, and further drive the clamping arm 1201 of the valve clamp 1200 to open or close.

[0048] Further, the diameter of the threaded rod 321 can be larger than that of the wire pressing post 311. Accordingly, the first sliding hole 13 in the housing 10 is arranged as a stepped hole, wherein the hole section with a larger diameter is located on the proximal side of the hole section with a smaller diameter, and the threaded rod 321 is matched with the hole section with a larger diameter. This setting method makes the lead of the threaded rod 321 larger, so that the driving knob 32 axially moves a longer distance when the number of rotation turns remains unchanged, that is, the driving efficiency of the driving knob 32 is improved, which is convenient for the operator to operate.

[0049] In this embodiment, the unloading knob 33 is located on the proximal side of the driving knob 32, that is, outside the housing 10. According to the above embodiment, the unloading knob 33 is connected to the actuating wire 20 passing through it. Exemplarily, the unloading knob 33 can be arranged in a cylindrical shape for easy screwing by the operator; the unloading knob 33 is provided with a second through hole 331 along the axial direction and one or more second locking holes 332 along the radial direction. The second locking holes 332 are used to install fasteners such as bolts or studs, and the actuating wire 20 located in the second through hole 331 is locked by the pressing method of the fasteners. Thus, the actuating wire 20 is relatively fixed to the unloading knob 33, and the actuating wire 20 can move or rotate synchronously with the wire pressing post 311. Further, the second locking holes 332 can be arranged as blind holes or through holes, and the specific structural form of the second locking holes 332 can refer to the first locking holes 3112 in the above embodiment, which will not be elaborated here.

[0050] It can be understood that in this embodiment, there is no gap left between the proximal end face of the driving knob 32 and the distal end face of the unloading knob 33, so as to ensure that when the driving knob 32 axially moves towards the distal end or the proximal end, it can drive the unloading wire pressing assembly 31 and the unloading knob 33 to move synchronously. On this basis, the valve clip control handle 100 further includes a bearing 70, and the driving knob 32 and the unloading knob 33 are respectively matched with the bearing 70. As Figure 7 shown, taking the driving knob 32 including a connected threaded rod 321 and a rotating head 322 as an example, the radial dimension of the rotating head 322 is larger than that of the unloading knob 33. The bearing 70 can be arranged in the rotating head 322, and the unloading knob 33 is partially inserted into the rotating head 322 and matched with the bearing 70. In this embodiment, by arranging the bearing 70, the rotation of one of the driving knob 32 and the unloading knob 33 is prevented from affecting the other, which not only improves the stability of the axial movement of the actuating wire 20, but also avoids the problem of loosening of the connection between the actuating wire 20 and the unloading knob 33 and the wire pressing assembly 31 caused by excessive torsion.

[0051] Based on the above embodiments, the wire pressing assembly 31 further includes a limiting block 312. The limiting block 312 is detachably connected to the wire pressing column 311. The connection method can be snap connection, plug connection, or connection through a detachable fastener, or a combination of multiple connection methods. In this embodiment, at least part of the limiting block 312 is located on the proximal side of the wire pressing column 311, that is, it is clamped between the wire pressing column 311 and the driving knob 32. It can be understood that the setting of the limiting block 312 can prevent the above two from directly contacting and causing the wire pressing column 311 to rotate with the driving knob 32. Thus, when the wire pressing column 311 and the actuating wire 20 perform a moving action, unnecessary rotational movements can be avoided. Therefore, not only the stability of the axial movement of the actuating wire 20 is improved, but also the problem of loosening of the connection between the actuating wire 20 and structures such as the wire pressing column 311 caused by excessive torsion is avoided.

[0052] Exemplarily, please continue to refer to Figure 7 , a connecting column is provided at the bottom of the limiting block 312. The connecting column is inserted into a connecting hole opened downward from the top of the wire pressing column 311. Further, with a plane perpendicular to the axial direction as the cross-section, the cross-sectional shape of the limiting block 312 is rectangular. The proximal end surface of the limiting block 312 extends beyond the proximal end surface of the wire pressing column 311, and the extending part extends downward to form a clamping portion 3122. The clamping portion 3122 is clamped between the wire pressing column 311 and the driving knob 32. According to the actuating wire 20 passing through the wire pressing column 311 and the driving knob 32, an avoidance groove can be axially provided on the clamping portion 3122 to ensure the smooth passing of the actuating wire 20. Thus, when the driving knob 32 rotates, since the limiting block 312 cannot rotate, the wire pressing column 311 will not rotate either.

[0053] Further, please continue to refer to Figure 7 , in some embodiments of the present invention, the wire pressing assembly 31 further includes a hand-tightening screw 313. The hand-tightening screw 313 is used to connect the limiting block 312 and the wire pressing column 311. Exemplarily, the hand-tightening screw 313 is inserted into the limiting block 312, and the handle screw extends into the wire pressing column 311 and is threadedly connected to the wire pressing column 311. The hand-tightening end of the hand-tightening screw 313 is exposed outside the housing 10, which is convenient for the operator to operate. Thus, the connection between the hand-tightening screw 313 and the wire pressing column 311 can be released by screwing the hand-tightening screw 313, and then the limiting block 312 can be removed. In an alternative embodiment, a threaded hole is provided in the limiting block 312, and the hand-tightening screw 313 is threadedly connected to the limiting block 312. Thus, after the hand-tightening screw 313 is disconnected from the wire pressing column 311, the hand-tightening screw 313 remains threadedly connected to the limiting block 312, and the operator can drive the limiting block 312 to disengage by pulling the hand-tightening screw 313, further improving the operation convenience.

[0054] Further, please refer to Figure 6The top of the housing 10 is provided with a first slide groove 131. Taking the housing 10 including the top cover 101 and the bottom shell 102 as an example, the first slide groove 131 is provided on the top cover 101, and the first slide groove 131 is connected with the first slide hole 13 in the housing 10. On this basis, in combination with reference to Figures 3 to 5 The limit block 312 is partially located in the first slide groove 131, and the width of the limit block 312 is slightly smaller than the width of the first slide groove 131, so that it is convenient to unload the limit block 312 from the first slide groove 131. Furthermore, the hand screw 313 inserted in the limit block 312 is exposed outside the housing 10, so that it is convenient for the operator to screw and remove the limit block 312 by pulling the hand screw 313, further improving the convenience of operation.

[0055] On the basis of the above embodiment, the length of the first slide groove 131 is greater than or equal to the maximum distance of axial movement of the wire pressing assembly 31. When the wire pressing assembly 31 slides axially as a whole, the limit block 312 can slide along the first slide groove 131. On this basis, the top surface of the limit block 312 is higher than the top surface of the housing 10. Further, as Figure 7 As shown, at least one side of the two sides of the limit block 312 is provided with an indicator portion 3121, and the indicator portion 3121 can be a columnar body integrally formed on the limit block 312, or a pointer-shaped component connected to the limit block 312. Accordingly, the shell 10 is provided with a plurality of scale lines 1011 that match the indicator portion 3121. The scale lines 1011 can provide the operator with an indication of the axial movement position of the actuator wire 20 by indicating the state of the clamping arm 1201 in the valve clamp 1200, such as the closed and open angles, etc., thereby facilitating the operator's observation and operation during the operation.

[0056] like Figure 4 and Figure 7 As shown, in some embodiments of the present invention, the actuating wire control mechanism 30 further includes a wire tube 34, which can be specifically configured as a stainless steel tube or a nickel-titanium alloy tube. The wire tube 34 is disposed in the housing 10, extending from the wire pressing column 311 toward the distal end, and its distal end penetrates into the sheath 1130, and the actuating wire 20 is penetrated in the wire tube 34. It can be understood that one end of the actuating wire 20 located in the housing 10 extends into the sheath 1130, and the other end is connected to the actuating wire control mechanism 30. In the process of axial movement with the wire pressing assembly 31, the middle part of the actuating wire 20 is prone to bending, so the wire tube 34 in this embodiment is used to limit the actuating wire 20 to prevent the actuating wire 20 from bending.

[0057] Further, according to the above embodiments, a guiding hole 15 for restricting the actuating wire 20 is provided in the sealing cavity 14 of the housing 10. In this embodiment, on the basis that the actuating wire control mechanism 30 includes a wire passing tube 34, the guiding hole 15 cooperates with the wire passing tube 34, and the wire passing tube 34 can axially slide within the guiding hole 15. Additionally, a through hole for the wire passing tube 34 to pass through is provided on the sealing ring 80 that encloses to form the sealing cavity 14, and a portion of the wire passing tube 34 near the proximal end extends through this through hole to the first sliding hole 13 and is inserted into the wire pressing column 311.

[0058] On the basis of the above embodiments, the portion of the wire passing tube 34 inserted into the wire pressing column 311 extends to pass through at least one first locking hole 3112, and a fastener provided in the first locking hole 3112 is used to lock the wire passing tube 34. Exemplarily, four first locking holes 3112 are provided on the wire pressing column 311, and studs are provided in two first locking holes 3112 near the distal end of the wire pressing column 311. The ends of both studs abut against the outer sidewall of the wire passing tube 34 to lock the wire passing tube 34; the studs provided in the other two first locking holes 3112 abut against the actuating wire 20 extending from the wire passing tube 34 to lock the actuating wire 20. Thus, when the wire pressing column 311 axially slides under the drive of the drive knob 32, the actuating wire 20 and the wire passing tube 34 both axially move synchronously with it, thereby preventing the actuating wire 20 from bending and improving the stability of the actuating wire 20.

[0059] Please refer to Figures 9 to 11 , when the limiting block 312 is connected to the wire pressing column 311, the actuating wire control mechanism 30 is in the first working condition. At this time, the operator can rotate the drive knob 32 clockwise or counterclockwise to make the drive knob 32, the wire pressing column 311, the limiting block 312, the wire passing tube 34, the unloading knob 33, and the actuating wire 20 axially move synchronously. Exemplarily, as Figure 9 shown, when moving towards the distal end, it can drive the clamping arm 1201 of the valve clamp 1200 to open, as Figure 10 shown, when moving towards the proximal end, it can drive the clamping arm 1201 to close. As Figure 11 shown, when the operator turns the hand-tightening screw 313 to remove the limiting block 312, the actuating wire control mechanism 30 is in the second working condition. At this time, the operator can rotate the unloading knob 33 to make the unloading knob 33, the wire pressing column 311, the wire passing tube 34, and the actuating wire 20 rotate synchronously around their own axes, thereby releasing the threaded connection between the actuating wire 20 and the sliding member 1203 in the valve clamp 1200, that is, dissociating the actuating wire 20 from the valve clamp 1200. Therefore, in this embodiment, the actuating wire control mechanism 30 can change the working condition only by removing the limiting block 312, and then control the actuating wire 20 to achieve different actions, improving the operation convenience. Furthermore, when applied to the delivery device 1100 and the valve repair system 1000, the surgical efficiency can be improved.

[0060] Please continue to refer to Figures 1 to 6 and, in combination with reference to Figures 8 to 11 , the pulling wire 40 is threaded through the capture arm 1202. The two wire ends of the pulling wire 40 extend proximally. In this embodiment, the pulling wire 40 can be made of nitinol wire or medical suture. It should be noted that when the valve clip 1200 includes two capture arms 1202, the pulling wire 40 can be provided as one piece. One pulling wire 40 passes through the two capture arms 1202 in sequence, so as to control the actions of the two capture arms 1202 simultaneously. Correspondingly, a pulling wire control mechanism 50 cooperating with the pulling wire 40 is provided in the valve clip control handle 100. The pulling wire 40 can also be provided as two pieces, and each pulling wire 40 is threaded through one capture arm 1202, so as to control the independent actions of the two capture arms 1202 respectively. Correspondingly, two pulling wire control mechanisms 50 are provided in the valve clip control handle 100.

[0061] The following embodiments will be described by taking the case where the pulling wire 40 is provided as two pieces as an example. Please continue to refer to Figure 8 and, in combination with reference to Figure 4 and Figure 5 , the four wire ends of the two pulling wires 40 are respectively inserted into the four channels of the sheath 1130 and penetrate into the housing 10 from the proximal end of the sheath 1130. Then, the two wire ends of one pulling wire 40 extend and are connected to one pulling wire control mechanism 50, and the two wire ends of the other pulling wire 40 extend and are connected to the other pulling wire control mechanism 50. In this embodiment, the two pulling wire control mechanisms 50 can be respectively arranged on both sides of the actuating wire control mechanism 30, which can not only avoid the interference between the two pulling wires 40, but also make full use of the space of the housing 10.

[0062] Please continue to refer to Figure 8 , in combination with reference to Figures 9 to 11, in some embodiments of the present invention, the pulling wire control mechanism 50 includes a control rod 51, a wire locking member 52 and a wire removing member 53. The pulling wire 40 is threaded through the control rod 51. The control rod 51 is at least partially slidably disposed in the housing 10. The control rod 51 can drive the pulling wire 40 to move so as to open and close the capture arm 1202. Taking two capture arms 1202 as an example, in this embodiment, the opening of the capture arm 1202 means that the two capture arms 1202 approach each other relatively and are in a state of waiting for capture. The closing of the capture arm 1202 means that the two capture arms 1202 move away from each other relatively and rotate towards the clamping arm 1201 to capture the valve. The wire locking member 52 is mounted on the control rod 51. The wire locking member 52 locks the pulling wire 40 under the first working condition and releases the pulling wire 40 under the second working condition. The wire removing member 53 is detachably mounted on the control rod 51 or the wire locking member 52 and is connected to the pulling wire 40. The wire removing member 53 can drive the pulling wire 40 to be disengaged from the capture arm 1202 under the second working condition.

[0063] Based on the above embodiment, a second sliding hole 16 is provided in the housing 10, and an orifice is provided on the proximal wall of the housing 10. The control rod 51 is slidably disposed in the second sliding hole 16. Taking the housing 10 including a top cover 101 and a bottom shell 102 as an example, grooves are respectively provided on the opposite sides of the top cover 101 and the bottom shell 102. When the two opposite grooves are engaged, the second sliding hole 16 is formed. The number of the second sliding holes 16 is the same as the number of the pulling wire control mechanisms 50. In this embodiment, two second sliding holes 16 are provided, and the two second sliding holes 16 are respectively located on both sides of the first sliding hole 13.

[0064] Further, a limiting protrusion 5101 is provided on the control rod 51. Correspondingly, as Figure 6 shown, a first limiting groove 162 and a second limiting groove 163 are provided on the housing 10. The first limiting groove 162 and the second limiting groove 163 are arranged along the sliding direction of the control rod 51. When the control rod 51 slides along the second sliding hole 16, the limiting protrusion 5101 can cooperate with the first limiting groove 162 or the second limiting groove 163. It can be understood that the control rod 51 can drive the pulling wire 40 to move, and further drive the capture arm 1202 of the valve clamp 1200 to open or close. In this embodiment, the first limiting groove 162 and the second limiting groove 163 can cooperate with the limiting protrusion 5101 to keep the control rod 51 in a fixed position, and further keep the pulling wire 40 in a state of driving the capture arm 1202 to open or in a state of driving the capture arm 1202 to close and capture. Therefore, such a setting method improves the stability of the pulling wire 40 and is convenient for the operator to operate.

[0065] In an alternative embodiment, the limiting protrusion 5101 can be set as an elastic structure. When the control rod 51 slides in the second sliding hole 16, the limiting protrusion 5101 undergoes elastic deformation. When it slides to the first limiting groove 162 or the second limiting groove 163, the limiting protrusion 5101 resumes deformation and extends into the first limiting groove 162 or the second limiting groove 163 to produce a fit. In another alternative embodiment, please refer to Figure 8 , the limiting protrusion 5101 is set as a bump integrally formed on the control rod 51. Correspondingly, as Figure 6 shown, a second sliding groove 161 communicating with the second sliding hole 16 is provided on the housing 10. When the control rod 51 slides along the second sliding hole 16, the limiting protrusion 5101 slides in the second sliding groove 161 accordingly. The first limiting groove 162 and the second limiting groove 163 are respectively communicated with the second sliding groove 161 and arranged along the length direction of the second sliding groove 161. Thus, when the limiting protrusion 5101 moves to align with the first limiting groove 162, the operator can rotate the control rod 51 to make the limiting protrusion 5101 cooperate with the first limiting groove 162; when the limiting protrusion 5101 moves to align with the second limiting groove 163, the operator can rotate the control rod 51 to make the limiting protrusion 5101 cooperate with the second limiting groove 163.

[0066] Based on the above embodiment, taking the housing 10 including the top cover 101 and the bottom shell 102 as an example, the second sliding groove 161, the first limiting groove 162 and the second limiting groove 163 can all be provided on the top cover 101 and penetrate through the top cover 101 along the thickness direction of the top cover 101 for the convenience of the operator's observation and operation. On this basis, as Figure 6 shown, a transparent cover plate 90 can also be installed on the housing 10. The transparent cover plate 90 is embedded in the second sliding groove 161, the first limiting groove 162 and the second limiting groove 163 to play a dust-proof role. In this embodiment, the part of the control rod 51 located in the first sliding hole 13 is set as a cylinder, so that the control rod 51 can rotate around its own axis in the first sliding hole 13, and then drive the limiting protrusion 5101 to rotate. The limiting protrusion 5101 is provided at the top of the control rod 51. The operator can rotate the control rod 51 by any angle between 10° and 90° to make the limiting protrusion 5101 snap into the first limiting groove 162 or the second limiting groove 163.

[0067] Furthermore, a handle part 512 is also provided on the control rod 51. The handle part 512 can be set as a pull rod, or can be set as a pull ring, or can also be set as other shapes convenient for the operator to hold. The shape of the handle part 512 is not specifically limited in this embodiment. The handle part 512 can be integrally formed on the control rod 51. For example, it can be on the same side of the control rod 51 as the limiting protrusion 5101, so as to facilitate the operator to operate the control rod 51 to slide and rotate by holding the handle part 512 and improve the operation convenience.

[0068] Further, in an alternative embodiment, both the wire-locking member 52 and the wire-removing member 53 are mounted on the control rod 51, and the wire-removing member 53 is connected to the proximal end of the control rod 51; in another alternative embodiment, as Figure 8 shown, the wire-locking member 52 is connected to the proximal end of the control rod 51, and the wire-removing member 53 is connected to the proximal end of the wire-locking member 52. On this basis, the wire-removing member 53 is provided as a wire-removing knob, and the wire-removing knob is threadedly connected to the proximal end of the wire-locking member 52. Exemplarily, the proximal end of the wire-locking member 52 is provided with an external thread, and the wire-removing knob is provided with a threaded hole, so that the wire-removing knob is detachably sleeved on the wire-locking member 52. In this embodiment, the threaded connection method facilitates the disassembly of the wire-removing member 53 and improves the operation convenience.

[0069] Further, as Figure 8 shown, the control rod 51 is axially provided with a wire-passing hole 511 for the pulling wire 40 to pass through, and the wire-passing hole 511 penetrates the control rod 51. The two wire ends of the pulling wire 40 penetrate into the wire-passing hole 511 from the distal end of the control rod 51. Taking the control rod 51, the wire-locking member 52, and the wire-removing member 53 being connected in sequence as an example, after the two wire ends of the pulling wire 40 extend out of the control rod 51, they extend into the wire-locking member 52 and are locked or loosened according to the working condition of the wire-locking member 52.

[0070] In some embodiments of the present invention, the wire-locking member 52 is provided as a two-way valve. The two-way valve includes a valve body and a handle. The handle is located at the top of the valve body. Connecting pipes are respectively extended and provided on both sides of the valve body. The connecting pipe near the distal end is used to connect with the control rod 51, and the connection method can be welding, threaded connection, etc. to ensure the connection reliability; the connecting pipe near the proximal end is used to connect with the wire-removing knob. In this embodiment, when the two-way valve is in the closed state, it can squeeze the pulling wire 40 passing through it, thereby locking it. When the two-way valve is in the open state, it can loosen the pulling wire 40. Such a setting facilitates the operator's operation and can ensure the stability of the pulling wire 40.

[0071] On the basis of the above embodiments, among the two wire ends of the pulling wire 40, the first wire end extends to cooperate with the wire-locking member 52, and the second wire end of the pulling wire 40 extends to connect with the wire-removing knob and can move with the wire-removing knob. That is to say, both wire ends of the pulling wire 40 cooperate with the wire-locking member 52. Taking the wire-locking member 52 being provided as a two-way valve as an example, the first wire end can extend to the proximal connecting pipe of the two-way valve, and the second wire end extends to the wire-removing knob and can be directly connected to the wire-removing knob or can be clamped between the wire-removing knob and the connecting pipe. As Figure 9 and Figure 10As shown, when the two-way valve is closed, both wire ends are locked. At this time, the pulling wire 40 is relatively fixed to the control rod 51 and the wire locking member 52. The operator can axially slide the control rod 51 to axially move the pulling wire 40, thereby driving the capture arm 1202 of the valve clip 1200 to open or close; as Figure 11 shown, when the two-way valve is open, both wire ends are released. At this time, the operator can pull the second wire end to draw out the pulling wire 40 and disconnect the pulling wire 40 from the valve clip 1200.

[0072] In some embodiments of the present invention, the second wire end of the pulling wire 40 is connected to the wire withdrawing knob. Thus, the operator can draw out the pulling wire 40 while unloading the wire withdrawing knob, and the operation is simple. Further, the connection manner between the second wire end of the pulling wire 40 and the wire withdrawing knob can be a fixed connection such as bonding, or, in another alternative embodiment, as Figure 8 shown, the wire withdrawing knob is axially provided with two through holes, and the second wire end of the pulling wire 40 is wound through the two through holes. Exemplarily, an installation post 531 can be provided at the distal end of the wire withdrawing knob, and the two through holes are penetrated through the installation post 531, and the proximal end of the installation post 531 is located inside the wire withdrawing knob, so as to prevent the pulling wire 40 from being exposed. The second wire end of the pulling wire 40 passes through one of the through holes from the direction of the distal end to the proximal end, and then passes through the other through hole from the direction of the proximal end to the distal end, and then returns to the distal side of the wire withdrawing knob. On this basis, a knotting portion 41 is provided at the second wire end, and the radial dimension of the knotting portion 41 is larger than the radial dimension of the through hole, so that the knotting portion 41 is clamped at the distal side of the wire withdrawing knob. Thus, the pulling wire 40 is connected to the wire withdrawing knob, and when the wire locking member 52 is in the second working condition, that is, when the pulling wire 40 is released, when the operator unloads the wire withdrawing knob, the pulling wire 40 can move with the wire withdrawing knob, so as to be disconnected from the valve clip 1200.

[0073] Please refer to Figure 9 and Figure 10 , when the two-way valve is closed, the pulling wire control mechanism 50 is in the first working condition. At this time, the operator can axially slide the control rod 51 to synchronously move the control rod 51, the two-way valve, the wire withdrawing knob and the pulling wire 40. When sliding towards the proximal end, the capture arm 1202 can be driven to open and enter the waiting-to-capture working condition; when sliding towards the distal end, since the capture arm 1202 is usually made of shape memory alloy, while the pulling wire 40 is loosened, the capture arm 1202 will return to the initial state, that is, rotate towards the clamping arm 1201 to close and capture the valve. After the valve is captured, please refer to Figure 11, the operator can open the two-way valve and loosen the pulling wire 40. At this time, the pulling wire control mechanism 50 is in the second working condition. The operator can turn the wire-removing knob to unload it, and then draw out the pulling wire 40, thereby releasing the connection between the pulling wire 40 and the capture arm 1202, that is, dissociating the pulling wire 40 from the valve clip 1200. Therefore, in this embodiment, the pulling wire control mechanism 50 changes the working condition by opening and closing the two-way valve, and then can complete the dissociation only by unloading the wire-removing knob, without having to search for the wire end or cut the pulling wire 40 in order to draw out the pulling wire 40, which improves the operation convenience. Furthermore, when applied to the delivery device 1100 and the valve repair system 1000, the surgical efficiency can be improved.

[0074] Please refer to Figure 1 , an embodiment of the second aspect of the present invention provides a delivery device 1100. The delivery device 1100 can be applied to interventional therapy and is used to deliver implants such as artificial valves, stents, valve clips 1200, etc. In this embodiment, the delivery device 1100 includes a sheath 1130, an adjustable bending sheath 1110, a sheath bending control handle 1120, and a valve clip control handle 100 according to the embodiment of the first aspect. The adjustable bending sheath 1110 is connected to the sheath bending control handle 1120 and bends in a set direction under the control of the sheath bending control handle 1120, so as to reach a specified position through an interventional channel in the patient's body, such as a venous blood vessel, etc. during the operation; the sheath 1130 is movably inserted into the adjustable bending sheath 1110, and the proximal end of the sheath 1130 is connected to the valve clip control handle 100.

[0075] In this embodiment, the adjustable bending sheath 1110 is a hollow sheath whose distal end can be bent or manipulated. The adjustable bending sheath 1110 is straight or approximately straight when not subjected to a bending force. Exemplarily, an adjustable bending tube section is provided at a position near the distal end of the adjustable bending sheath 1110, and the control wire in the sheath bending control handle 1120 is connected to the adjustable bending tube section. Thus, the sheath bending control handle 1120 can bend the distal end of the sheath bending control handle 1120 by pulling the control wire. On this basis, the sheath 1130 is inserted into the adjustable bending sheath 1110 and can bend synchronously with the adjustable bending sheath 1110.

[0076] Please continue to refer to Figure 1 , an embodiment of the third aspect of the present invention provides a valve repair system 1000. The valve repair system 1000 includes a valve clip 1200 and a delivery device 1100 according to the embodiment of the second aspect. The sheath 1130 of the delivery device 1100 is detachably connected to the valve clip 1200 to deliver the valve clip 1200.

[0077] Exemplarily, the delivery device 1100 includes two adjustable bending sheaths 1110, two sheath bending control handles 1120, a sheath 1130, and a valve clip control handle 100. The two adjustable bending sheaths 1110 are respectively a primary sheath 1111 and a secondary sheath 1112. The secondary sheath 1112 is inserted into the primary sheath 1111. The two sheath bending control handles 1120 are respectively engaged with the primary sheath 1111 and the secondary sheath 1112 to control the primary sheath 1111 and the secondary sheath 1112 to bend in a set direction. The sheath 1130 is inserted into the secondary sheath 1112. The distal end of the sheath 1130 extends out of the secondary sheath 1112 and is detachably connected to the valve clip applicator 1200. The proximal end of the sheath 1130 extends out of the secondary sheath 1112 and is connected to the valve clip control handle 100.

[0078] When the valve repair system 1000 proposed in this embodiment is applied to mitral valve repair surgery, the operator operates the sheath bending control handle 1120 to control the primary sheath 1111 to reach the specified position in the patient's body through the established access channel. The secondary sheath 1112 extends out of the primary sheath 1111 and drives the sheath 1130 and the valve clip applicator 1200 to reach near the mitral valve. After adjusting the position, as Figure 9 shown, by rotating the drive knob 32 of the actuating wire control mechanism 30, the actuating wire 20 is driven to move distally, so that the clamping arms 1201 of the valve clip applicator 1200 are opened. By pushing the control rod 51 of the pulling wire control mechanism 50, the pulling wire 40 is driven to move proximally, so that the catching arms 1202 of the valve clip applicator 1200 are opened and stay in a position where the valve can be caught. Then, the control rod 51 is pushed distally to loosen the pulling wire 40, and then the catching arms 1202 recover their deformation and rotate towards the clamping arms 1201 to complete the catching of the valve. By rotating the drive knob 32 in the reverse direction, as Figure 10 shown, the actuating wire 20 is driven to move proximally, so that the clamping arms 1201 are closed to complete the clamping. As Figure 11 shown, the two-way valve in the pulling wire control mechanism 50 is opened, and the wire withdrawal knob is unscrewed to withdraw the pulling wire 40 and dissociate the pulling wire 40 from the valve clip applicator 1200. The hand-tightening screw 313 in the actuating wire control mechanism 30 is turned to unload the limit block 312, and the unloading knob 33 is rotated to dissociate the actuating wire 20 from the valve clip applicator 1200. Finally, the primary sheath 1111, the secondary sheath 1112, and the sheath 1130 are withdrawn. During the use of the valve repair system 1000 proposed in this embodiment, the operator can complete actions such as delivering the valve clip applicator, catching the valve, clamping the valve, dissociating and withdrawing the delivery device without the aid of external tools, with high functional integration and convenient operation.

[0079] The above are only the preferred specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily thought of by those skilled in the art within the technical scope disclosed by the present invention should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. A valve clip control handle for controlling a valve clip applicator, the valve clip applicator comprising a plurality of relatively opening and closing clamping arms, characterized in that, The valve clip control handle includes a housing, an actuating wire, and an actuating wire control mechanism. The actuating wire is partially located in the housing. The distal end of the actuating wire can be threadedly connected to the valve clip through a sheath tube. The actuating wire control mechanism includes: A wire pressing assembly that is slidably disposed in the housing and connected to the actuating wire. The wire pressing assembly is configured to be able to move synchronously with the actuating wire under a first working condition and allow the actuating wire to rotate under a second working condition. The wire pressing assembly includes a wire pressing column and a limiting block. The actuating wire is threaded through the wire pressing column. The limiting block is detachably connected to the wire pressing column and is at least partially located on the proximal side of the wire pressing column. The limiting block can prevent the wire pressing column from rotating when connected to the wire pressing column. A driving knob that abuts against the proximal end of the wire pressing assembly and is threadedly connected to the housing. The driving knob can push the wire pressing assembly and the actuating wire to move to drive the clamping arms to open and close. An unloading knob that abuts against the proximal end of the driving knob and is connected to the actuating wire. The unloading knob is configured to be able to move synchronously with the actuating wire under the first working condition and be able to drive the actuating wire to rotate to disconnect from the valve clip under the second working condition.

2. The valve clip control handle according to claim 1, wherein, The wire pressing assembly further includes a hand-tightening screw that is inserted into the limiting block and is detachably connected to the wire pressing column. The end of the hand-tightening screw protrudes outside the housing.

3. The valve clip control handle according to claim 1, characterized in that The actuating wire control mechanism further includes a wire passing tube that extends distally from inside the wire pressing column and can pass through the sheath tube. The actuating wire is partially threaded through the wire passing tube.

4. The valve clip control handle according to claim 3, wherein The wire pressing column is axially provided with a first through hole and at least one first locking hole communicating with the first through hole in the radial direction. The first locking hole is used to install a fastener to lock the actuating wire and / or the wire passing tube located in the first through hole.

5. The valve clip control handle according to claim 1, wherein The valve clip control handle further includes a bearing, and the driving knob and the unloading knob are respectively matched with the bearing.

6. The valve clip control handle according to claim 5, characterized in that, The driving knob includes a threaded rod and a rotating head connected to each other. The bearing is disposed inside the rotating head. The unloading knob is partially inserted into the rotating head and is matched with the bearing.

7. The valve clip control handle according to claim 1, characterized in that, The unloading knob is axially provided with a second through hole and one or more second locking holes in the radial direction. The second locking holes are used to install fasteners to lock the actuating wire located in the second through hole.

8. A conveying device, characterized in that, The delivery device includes a sheath tube, an adjustable bending sheath, a sheath tube bending control handle, and the valve clip control handle according to any one of claims 1 to 7. The adjustable bending sheath is connected to the sheath tube bending control handle. The sheath tube is movably inserted into the adjustable bending sheath. The proximal end of the sheath tube is connected to the valve clip control handle.

9. A valve repair system, characterized in that, The valve repair system includes a valve clip and the delivery device according to claim 8. The sheath tube of the delivery device is detachably connected to the valve clip to deliver the valve clip.

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