A multi-channel valve bank structure and a semi-automatic sampler and sampling method for a dissolution tester

Abstract

The present application belongs to the field of preparation inspection, and specifically provides a multi-channel valve row structure, a dissolution instrument semi-automatic sampler and a sampling method. The multi-channel valve row structure includes three types of plug-in multi-channel valve row structure, pull-out multi-channel valve row structure and rotary multi-channel valve row structure. The dissolution instrument semi-automatic sampler includes a multi-channel valve row structure, a syringe cylinder fixing block structure, a syringe piston fixing block structure, an upper plate body structure, a rotating structure, a middle plate body structure and a lower plate body structure. The upper plate body structure and the lower plate body structure are fixed through the left plate body and the right plate body of the middle plate body structure. The multi-channel valve row structure is connected with the syringe cylinder fixing block structure and the syringe piston fixing block structure in front and back of the upper plate body. The rotating structure is connected with the syringe piston fixing block structure. The instrument and the testing method thereof can ensure the synchronization and timeliness of sampling and liquid supplementing through the regulation of pipelines and interface conversion. The instrument has simple structure, low cost and convenient operation, and is beneficial to popularization.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of preparation inspection, and particularly relates to a multi-channel valve connection structure, a semi-automatic sampler for a dissolution tester, and a sampling method. BACKGROUND

[0002] In the process of basket and paddle dissolution test of solid, semi-solid and part of liquid dosage forms, fast and accurate sampling and liquid supplementing are important links in the operation process. At present, there are mainly two methods for dissolution sampling and liquid supplementing: one is manual sampling, which requires the operator to take and filter an equal amount of liquid from the same position of the dissolution cup within 30 seconds, which requires high accuracy and speed of the operator; the other is automatic sampling, which uses the automatic sampling device of the dissolution tester to complete the sampling within 30 seconds, which requires high precision of the equipment control system.

[0003] The conventional automatic sampling device of the dissolution tester (such as Chinese patent documents CN201810168110.7 and CN201911395182.6) usually includes a sampling needle and a sample injection needle, a sampling and liquid supplementing pipeline system, an electromagnetic multi-channel valve device, a stepping motor, a piston device, a test tube and a test tube rack, a liquid supplementing cup, a waste liquid tank, etc. Among them, the public channel of the electromagnetic multi-channel valve device is connected with the piston device, and each channel valve is connected with the sampling needle, the dissolution cup, the sample injection needle, the liquid supplementing cup, and the external air through the pipeline system, respectively, and mainly performs sampling, sample injection, liquid supplementing, etc. by adjusting the communication mode; the sample injection needle is installed on a rack, and the position of the rack is adjusted up and down and horizontally by a stepping motor to achieve the purpose of injecting liquid into the test tube and the waste liquid tank; after each liquid supplementing is completed, the air in the pipeline system is sucked to empty the waste liquid. This technology mainly relies on switching the multi-channel valve device to make different branches communicate with the public channel, so that the piston device controlled by the stepping motor communicates with the corresponding pipeline under different conditions, to quickly and accurately complete the operations of automatic sampling, automatic liquid supplementing, automatic pipeline cleaning, automatic pipeline emptying, etc. Typical automatic sampling devices with similar principles include the Tianda Tianfa ADFC1207DP dissolution sampling collection system, the Logan SYSTEM 860DL dissolution sampling system, the Fuxikesi FADT-1202QY automatic sampler, the Hanson Research Vision G2 Autoplus automatic sampler, and the Agilent 850DS dissolution automatic sampling workstation, etc.

[0004] Manual sampling operation is greatly affected by personnel proficiency, time-consuming and laborious, and has large deviation. The operation mode of manually pushing the replenishment medium into the dissolution cup by the syringe is also not very convenient and timely. Generally, 2-3 people are needed to operate the 12-cup dissolution instrument simultaneously, which is difficult to realize synchronous sampling, and is easy to introduce human deviation, which may reduce the repeatability and accuracy of the determination results. The automatic sampling operation uses an instrument with complex structure (each dissolution cup corresponds to a separate automatic sampler), a precise control system, and an expensive market price (usually the price of an automatic sampling device is 2-5 times the price of a matching dissolution instrument). The solution pipeline is too long (the dead volume of the sampling pipeline is large, which may increase the risk of drug residue and cross infection, and reduce the temperature of the replenishment medium), and most of the equipment injects the drug solution into the test tube instead of directly into the sample vial. Based on the above situation, it is necessary to develop a semi-automatic sampler which can not only reduce the labor intensity, ensure convenient operation, perfect function and reliable results, but also reduce the production cost of the equipment and the threshold of market popularization. SUMMARY

[0005] For the above prior art, the main purpose of the present application is to provide a multi-channel valve array structure to overcome the shortcomings of manual sampling labor intensity, inaccurate and non-uniform interval time and sampling volume, and the limitations of expensive automatic sampling equipment, difficult popularization, and difficult human intervention and control during the experiment. The instrument and equipment of the present application not only can greatly reduce the production cost of the instrument and the technical requirements of the personnel, but also are beneficial to flexible control of the experimental process and direct injection of the drug solution into the sample vial.

[0006] To achieve the above purpose, the technical scheme of the present application is as follows:

[0007] The main components of the plug-in multi-channel valve array structure of the present application include a rotating screw fixing block structure, a plug moving block structure and a plug-in multi-channel valve conversion block structure. The rotating screw fixing block structure is used to fix the position of the rotating screw and promote the forward and backward movement of the plug moving block structure. The plug moving block structure is used to convert the communication position of the plug-in multi-channel valve conversion block structure by moving forward, backward, left and right. The plug-in multi-channel valve conversion block structure is used to synchronously control the sampling, liquid supplementing and liquid injection operations through the internal pipeline system. To ensure the accuracy of the straight pipe plug insertion, the diameter of the pipeline opening on the side of the plug-in multi-channel valve conversion block structure receiving the straight pipe plug should be slightly larger than the diameter of the pipeline.

[0008] Unlike the electromagnetic multi-channel valve device of the automatic sampler of the dissolution tester in the prior art, in the plug-in multi-channel valve row structure, the rotating screw fixing block bottom sheet is placed in the groove above the fixed bottom plate, so that it can only move within the moving boundary of the rotating screw fixing block bottom sheet. The upper surface of the rotating screw fixing block bottom sheet has a sheet fixed to the fixed bottom plate. The shape of the sheet can only allow the rotating screw fixing block to move within the moving boundary of the rotating screw fixing block, thereby limiting the movable position of the rotating screw fixing block structure and ensuring smooth left and right movement. Similarly, the plug moving block bottom sheet is placed in the groove above the fixed bottom plate, so that it can only move within the moving boundary of the plug moving block bottom sheet. The upper surface of the plug moving block bottom sheet has a sheet fixed to the fixed bottom plate. The shape of the sheet can only allow the plug moving block to move within the moving boundary of the plug moving block, thereby limiting the movable position of the plug moving block structure and ensuring smooth forward and backward movement. The fixed bottom plate is directly fixed to the upper plate body.

[0009] The rotating screw fixing block structure is preferably a solid plastic or metal rectangular structure. The position of the rotating screw is fixed by the bearing in the rotating screw fixing block bearing cavity, so that the position of the rotating screw relative to the rotating screw fixing block structure is always fixed and can rotate freely. To ensure that the plug moving block structure and the rotating screw fixing block structure can move left and right synchronously in position, the cylindrical synchronization shaft is inserted into the cylindrical synchronization shaft sleeve of the plug moving block structure to drive each other.

[0010] The plug moving block structure is preferably a solid plastic or metal rectangular structure. After the rotating screw in the plug moving block threaded cavity is rotated, the threads in the plug moving block threaded cavity move along the thread pattern of the rotating screw, which causes the plug moving block to move forward and backward, thereby realizing the insertion or removal of the straight pipe plug into the plug-in multi-channel valve conversion block. The plug moving block is connected to the syringe on the syringe cylinder fixing block structure through the plug moving block hose, which can ensure that the position of the syringe is not affected when the plug moving block moves. The plug moving block is connected to the plug-in multi-channel valve conversion block structure through the straight pipe plug, which can ensure that the syringe connected by the straight pipe plug can be connected to the correct plug-in multi-channel valve conversion block channel.

[0011] The plug-in multi-channel valve conversion block structure is directly fixed on the upper plate body, and the straight pipe plug of the plug-in plug moving block structure is connected through the plug-in upper straight channel, the plug-in lower straight channel, the plug-in upper curved channel and the plug-in lower curved channel; the liquid medicine is injected into the sample vial through the plug-in multi-channel valve conversion block lower column head; and the dissolution cup and the liquid supplementing cup are connected through the plug-in multi-channel valve conversion block hose. When the syringe is connected to the plug-in upper straight channel and the plug-in lower straight channel, the dissolution medium is sucked through the plug-in upper straight channel, and the liquid medicine in the dissolution cup is sucked through the plug-in lower straight channel; when the syringe is connected to the plug-in upper curved channel and the plug-in lower curved channel, the dissolution medium is added to the dissolution cup through the plug-in upper curved channel, and the extracted liquid medicine is injected into the sample vial through the plug-in lower curved channel.

[0012] In a preferred scheme, in the plug-in multi-channel valve conversion block structure, the plug-in upper straight channel is directly above the plug-in lower straight channel, the plug-in upper curved channel is directly above the plug-in lower curved channel, and the plug-in multi-channel valve conversion block lower column head is directly connected to the lower side of the plug-in lower curved channel. The channel structure composed of the plug-in upper straight channel and the plug-in lower straight channel and the channel structure composed of the plug-in upper curved channel and the plug-in lower curved channel are arranged in a repeated and adjacent manner. The diameters of the plug-in upper straight channel, the plug-in lower straight channel, the plug-in upper curved channel and the plug-in lower curved channel are approximately equal to the outer diameter of the syringe nipple. The number of the channel structure composed of the plug-in upper straight channel and the plug-in lower straight channel is equal to the number of the channel structure composed of the plug-in upper curved channel and the plug-in lower curved channel, and the specific number is equal to the number of the dissolution cup. The number of the straight pipe plug is equal to the number of the plug moving block hose, and is also equal to the number of the channel structure composed of the plug-in upper straight channel and the plug-in lower straight channel or the number of the channel structure composed of the plug-in upper curved channel and the plug-in lower curved channel.

[0013] In another preferred scheme, in the plug moving block structure, the ports of the plug moving block internal channel on the front and rear walls are connected to the straight pipe plug and the plug moving block hose respectively. The left and right distances between the straight pipe plugs are equal to the left and right distances between the plug moving block hoses, and both are twice the left and right distances between the channel structure composed of the plug-in upper straight channel and the plug-in lower straight channel and the channel structure composed of the plug-in upper curved channel and the plug-in lower curved channel.

[0014] The main components of the pull-out multi-channel valve bank structure of the present application include an outer frame structure and a pull-out central shaft structure. The outer frame structure is used to regulate the flow of liquid medicine and medium by fixing the pull-out central shaft structure and connecting the internal pipeline of the pull-out central shaft structure. The pull-out central shaft structure is used to synchronously control the sampling, liquid supplementing and liquid injecting operations through the internal pipeline system. To ensure the precision of the docking of the pipeline ports in the outer frame structure and the pull-out central shaft structure, the positioning insert block is tightly clamped in the outer frame positioning square hole and the central shaft liquid supplementing positioning square hole / central shaft sampling positioning square hole, and the lower part of the positioning insert block is a semicircular spherical protrusion to facilitate insertion.

[0015] Unlike the electromagnetic multi-channel valve device of the automatic sampler of the dissolution tester in the prior art, in the pull-out multi-channel valve bank structure, the outer frame structure is directly fixed on the upper plate body and tightly clamped with the pull-out central shaft structure. The outer frame structure accommodates and tightly clamps the pull-out central shaft structure through the middle square hole, connects with the pull-out upper straight channel, the pull-out lower straight channel and the pull-out upper curved channel of the pull-out central shaft structure through the outer frame channel, connects with the pull-out lower curved channel through the lower stem of the pull-out multi-channel valve, determines the corresponding positions of the channels of the pull-out central shaft structure and the outer frame channel through the positioning insert block placed in the outer frame positioning square hole and the central shaft liquid supplementing positioning square hole / central shaft sampling positioning square hole, connects with the syringe externally through the outer frame channel, connects with the dissolution cup and the liquid supplementing cup through the outer frame hose, and injects the liquid medicine into the sample vial through the lower stem of the pull-out multi-channel valve.

[0016] The pull-out central shaft structure moves the position of the pull-out central shaft in the outer frame through the pull-out central shaft handle, connects the syringe with the dissolution cup and the liquid supplementing cup through the pull-out upper straight channel, the pull-out lower straight channel, the pull-out upper curved channel and the pull-out lower curved channel via the outer frame channel, sucks the dissolution medium through the pull-out upper straight channel and the liquid medicine in the dissolution cup through the pull-out lower straight channel when the syringe connects with the pull-out upper straight channel and the pull-out lower straight channel, supplements the dissolution medium to the dissolution cup through the pull-out upper curved channel and injects the extracted liquid medicine into the sample vial through the pull-out lower curved channel and the lower stem of the pull-out multi-channel valve when the syringe connects with the pull-out upper curved channel and the pull-out lower curved channel, and the top end of the pull-out central shaft is a semicircular spherical protrusion to enable the pull-out central shaft structure to freely move in the outer frame structure.

[0017] In a preferred scheme, in the above-mentioned pull-type middle shaft structure, the pull-type upper straight channel is located directly above the pull-type lower straight channel, the pull-type upper curved channel is located directly above the pull-type lower curved channel, and the pull-type multi-channel valve lower stem is directly connected to the lower side opening of the pull-type lower curved channel. The channel structure composed of the pull-type upper straight channel and the pull-type lower straight channel is arranged in a repeated and adjacent manner with the channel structure composed of the pull-type upper curved channel and the pull-type lower curved channel. The diameters of the pull-type upper straight channel, the pull-type lower straight channel, the pull-type upper curved channel, and the pull-type lower curved channel are approximately equal to the outer diameter of the syringe nipple. The number of the channel structure composed of the pull-type upper straight channel and the pull-type lower straight channel is equal to the number of the channel structure composed of the pull-type upper curved channel and the pull-type lower curved channel, and the specific number is equal to the number of the dissolution cup. The pull-type middle shaft has a layer of rubber plated on each of the two side walls with pipe openings, so that the pipe interfaces of the outer frame structure and the pull-type middle shaft structure are tightly combined and cannot leak liquid.

[0018] In another preferred scheme, in the above-mentioned outer frame structure, the outer frame channels on the front and rear walls of the outer frame correspond to each other, and the outer frame channels on the rear wall are connected to the outer frame hoses. The number of the outer frame hoses is equal to the number of the channel structure composed of the pull-type upper straight channel and the pull-type lower straight channel or the number of the channel structure composed of the pull-type upper curved channel and the pull-type lower curved channel. The number of the pull-type multi-channel valve lower stem is half of the number of the outer frame hoses. The left-right distance between the outer frame channels on the front and rear walls of the outer frame is twice the left-right distance between the channel structure composed of the pull-type upper straight channel and the pull-type lower straight channel and the channel structure composed of the pull-type upper curved channel and the pull-type lower curved channel.

[0019] The main components of the rotary multi-channel valve block structure of the present application include a rotary multi-channel valve block structure and a multi-channel valve rotary body. The rotary multi-channel valve block structure is used to adjust the flow of liquid and medium by fixing the multi-channel valve rotary body and connecting the internal pipes of the multi-channel valve rotary body. The multi-channel valve rotary body is used to synchronously control the sampling, liquid supplementing, and liquid injection operations through the internal pipe system. To ensure the precision of the pipe port docking of the rotary multi-channel valve block structure and the multi-channel valve rotary body, the rotary body rod fixing groove tightly clamps the rotary body rod to ensure the stability of the position of the rotary body rod.

[0020] Unlike the electromagnetic multi-channel valve device of the automatic sampler of the dissolution tester in the prior art, in the rotary multi-channel valve block structure, the rotary multi-channel valve block structure is directly fixed on the upper plate body and tightly clamps each multi-channel valve rotary body. Among them, the rotary multi-channel valve block structure contains and clamps the multi-channel valve rotary body through the internal cylindrical cavity; through the rotary multi-channel valve block channel and the rotary upper straight channel, the rotary lower straight channel, and the rotary upper curved channel of the multi-channel valve rotary body, through the rotary multi-channel valve rotary body lower cylinder head and the rotary lower curved channel; by pressing the rotary body rod fixing block to make the lower spring compressed, the position is lowered, the rotary body rod of the multi-channel valve rotary body is manually moved left and right in the range defined by the rotary body rod position baffle to above the rotary body rod fixed groove, and the pressing of the rotary body rod fixing block is ended, so that the rotary body rod of the multi-channel valve rotary body falls into the rotary body rod fixed groove, to adjust the position of each channel of the multi-channel valve rotary body corresponding to the rotary multi-channel valve block channel; the rotary multi-channel valve block channel is connected to the syringe outward, the rotary multi-channel valve block hose is connected to the dissolution cup and the liquid supplementing cup, and the liquid is injected into the sampling vial through the rotary multi-channel valve rotary body lower cylinder head.

[0021] Among them, the lower cylindrical cup of the multi-channel valve rotary body is clamped in the cylindrical cavity of the rotary multi-channel valve block structure, the upper cylindrical lower side is connected with the lower cylindrical body and extends out through the gap between the two fixed plates, the upper side is connected with the rotary body rod, and the fixed plate holes of the two fixed plates are fixed in the rotary multi-channel valve block structure through fixed plate screws; the position of the rotary body is moved by manually moving the rotary body rod of the multi-channel valve rotary body by 90° angle; the syringe and the dissolution cup and the liquid supplementing cup are connected through the rotary upper straight channel, the rotary lower straight channel, the rotary upper curved channel, and the rotary lower curved channel via the rotary multi-channel valve block channel; when the syringe connects the rotary upper straight channel and the rotary lower straight channel, the dissolution medium is sucked through the rotary upper straight channel, and the liquid in the dissolution cup is sucked through the rotary lower straight channel; after rotation, when the syringe connects the rotary upper curved channel and the rotary lower curved channel, the dissolution medium is added to the dissolution cup through the rotary upper curved channel, and the extracted liquid is injected into the sampling vial through the rotary multi-channel valve rotary body lower cylinder head via the rotary lower curved channel.

[0022] In a preferred scheme, in the same multi-channel valve rotary body, the rotary upper straight channel is located directly above the rotary lower straight channel, the rotary upper curved channel is located directly above the rotary lower curved channel, the rotary multi-channel valve rotary body lower cylinder penetrates vertically downward through the rotary multi-channel valve block structure bottom hole, the channel structure composed of the rotary upper straight channel and the rotary lower straight channel is arranged vertically and does not intersect with the channel structure composed of the rotary upper curved channel and the rotary lower curved channel. The diameters of the rotary upper straight channel, the rotary lower straight channel, the rotary upper curved channel, and the rotary lower curved channel are approximately equal to the outer diameter of the syringe nipple. The number of channel structures composed of the rotary upper straight channel and the rotary lower straight channel is equal to the number of channel structures composed of the rotary upper curved channel and the rotary lower curved channel, and the specific number is equal to the number of dissolution cups used. The side surface of the lower cylinder of the multi-channel valve rotary body is plated with a layer of rubber to ensure that the multi-channel valve rotary body and the pipe interface inside the rotary multi-channel valve block structure are tightly combined and cannot leak liquid.

[0023] In another preferred scheme, in the rotary multi-channel valve block structure, the rotary multi-channel valve block channel positions on the front and rear walls of the rotary multi-channel valve block correspond to each other, the multi-channel valve block channels on the rear wall are connected to the rotary multi-channel valve block hoses. The number of rotary multi-channel valve block channels on the front wall of the rotary multi-channel valve block is the sum of the number of rotary multi-channel valve block hoses connected to the rear wall and the number of rotary multi-channel valve rotary body lower cylinders.

[0024] The application also provides an instrument for sampling dissolution experiments using the above multi-channel valve block structure, i.e., a dissolution tester semi-automatic sampler for rapid and convenient sampling. The dissolution tester semi-automatic sampler includes a multi-channel valve block structure (one of an insertion type multi-channel valve block structure, a pull-out type multi-channel valve block structure, and a rotary type multi-channel valve block structure), a syringe cylinder fixing block structure, a syringe piston fixing block structure, an upper plate body structure, a rotating structure, a middle plate body structure, and a lower plate body structure. The upper plate body structure and the lower plate body structure are fixed to the left and right sides of the middle plate body structure through the left plate body and the right plate body on the left and right sides of the middle plate body structure, the multi-channel valve block structure is directly fixed to the upper plate body, and the front and rear are connected to the syringe cylinder fixing block structure and the syringe piston fixing block structure fixed to the upper plate body; the rotating structure is clamped on the outer side of the upper plate body structure and is connected to the syringe piston fixing block structure.

[0025] In a preferred scheme, any one of the above multi-channel valve block structure insertion type multi-channel valve block structure, pull-out type multi-channel valve block structure, and rotary type multi-channel valve block structure.

[0026] In a preferred embodiment, the aforementioned syringe cylinder fixing block structure comprises a syringe cylinder fixing block, a cylinder fixing block long column fixing position, a cylinder fixing block long screw hole, a cylinder fixing block short screw hole, a cylinder fixing block syringe piston handle hole, a cylinder fixing block syringe cylinder handle clamping point, a cylinder fixing block short screw, a cylinder fixing block long column, a cylinder fixing block long column long screw hole, a cylinder fixing block long column short screw hole, a cylinder fixing block long column handle, a syringe cylinder hole, a cylinder clamping block plate fixing position, a syringe cylinder clamping block plate, a syringe cylinder clamping block column, a cylinder clamping block long screw hole, a cylinder fixing block long screw, the syringe passes through the syringe cylinder fixing block through the syringe cylinder hole, the syringe cylinder handle is clamped at the cylinder fixing block syringe cylinder handle clamping point, and the syringe piston enters the cylinder fixing block syringe cylinder handle clamping point through the cylinder fixing block long column fixing position, passes out of the syringe cylinder fixing block through the cylinder fixing block syringe piston handle hole, and is fixed to the syringe piston fixing block structure. After the syringe is placed in the designated position, the cylinder fixing block long column handle is inserted into the cylinder fixing block long column fixing position by holding the cylinder fixing block long column handle, and the cylinder fixing block short screw is screwed into the cylinder fixing block long column short screw hole and the cylinder fixing block short screw hole in sequence to fix the cylinder fixing block long column; the other side of the syringe cylinder fixing block places the syringe cylinder clamping block plate with the syringe cylinder clamping block column into the cylinder clamping block plate fixing position, and the cylinder fixing block long screw is screwed into the cylinder fixing block long column long screw hole, the cylinder clamping block long screw hole, and the cylinder fixing block long screw hole in sequence to integrally fix the cylinder fixing block long column and the syringe cylinder clamping block, thereby fixing the position of the syringe. The opposite side of the cylinder fixing block long column handle of the cylinder fixing block long column is a semispherical convex, which is beneficial to the insertion of the cylinder fixing block long column and matches the shape of the semispherical groove at the corresponding position of the cylinder fixing block long column fixing position, and can play a fixing role on this side; the position of the syringe cylinder clamping block column between the upper and lower syringes ensures that the syringes cannot shake up and down during use; the syringe cylinder hole penetrates the syringe cylinder fixing block on the side where the syringe cylinder clamping block is placed, and only penetrates the syringe cylinder fixing block in the range of the cylinder fixing block syringe piston handle hole on the side where the cylinder fixing block long column is placed.

[0027] In a preferred embodiment, the aforementioned injector piston fixing block structure comprises an injector piston fixing block, a piston fixing block long column fixing position, a piston fixing block bottom sliding body, a piston fixing block injector piston handle hole, a piston fixing block injector piston handle clamping point, a piston fixing block threaded cavity, a piston fixing block long column, a piston fixing block long column threaded cavity, a piston fixing block long column screw hole, a piston fixing block long column handle, a piston fixing block screw, a piston fixing block screw hole, an injector piston protruding from an injector cylinder fixing block, entering the piston fixing block injector piston handle clamping point via the piston fixing block long column fixing position, the piston column passing through the piston fixing block injector piston handle hole, and the piston handle remaining in the piston fixing block injector piston handle clamping point. After the injector piston is placed in the designated position of the injector piston fixing block, the piston fixing block long column is inserted into the piston fixing block long column fixing position by holding the piston fixing block long column handle, and the piston fixing block screw is screwed into the piston fixing block long column screw hole and the piston fixing block screw hole in sequence to fix the piston fixing block long column. The main handle of the manual rotation structure or the motor of the motor rotation structure is rotated in sequence to screw into the piston fixing block threaded cavity and the piston fixing block long column threaded cavity to integrally fix the injector piston fixing block and the piston fixing block long column, and to enable the injector piston fixing block structure to move forward and backward. The piston fixing block bottom sliding body is clamped in the piston fixing block bottom sliding body clamping position of the upper plate body structure to fix the direction and stability of the movement of the injector piston fixing block structure. The opposite side of the piston fixing block long column handle of the piston fixing block long column is a semicircular spherical protrusion, which is beneficial to the insertion of the piston fixing block long column into the piston fixing block long column fixing position, and the shape of the semicircular spherical recess corresponding to the position of the piston fixing block long column fixing position matches, which can play a fixing role on this side; the injector piston handle is fixed in the flat cylindrical piston fixing block injector piston handle clamping point composed of the injector piston fixing block and the piston fixing block long column, and the injector piston column can be moved and clamped through the square piston fixing block injector piston handle hole by virtue of the cross-shaped body piece composed of the four square column on the piston column.

[0028] In a preferred embodiment, the aforementioned upper plate body structure comprises an upper plate body, a multi-channel valve door row structure screw hole, a side handle screw fixing block, a side handle stirring screw, a side handle, a cylinder fixing block screw hole, a piston fixing block bottom sliding body clamping position,

[0029] The outer side of the upper plate body is a protruding cuboid for fixing the mobile phone rotating structure or the motor rotating structure. The piston fixing block bottom sliding body stop can exactly stop the piston fixing block bottom sliding body to fix the direction and stability of the syringe piston fixing block structure movement. The cylinder fixing block screw hole is used to fix the syringe cylinder fixing block structure in the upper plate body structure. The multi-channel valve bank structure screw hole is used to fix the plug-in multi-channel valve bank structure, pull-out multi-channel valve bank structure or rotary multi-channel valve bank structure in the upper plate body structure. The side handle screw fixing block is directly fixed on the right side of the upper plate body. The side handle stirring screw is clamped in the side handle screw fixing block through a bearing. The side handle and the side handle stirring screw are integrated to rotate the side handle stirring screw. The side handle stirring screw connects the chain of the plug-in multi-channel valve bank structure to drive the rotation of the plug-in multi-channel valve bank structure, so that the rotation screw fixing block of the side handle stirring screw can move forward and backward.

[0030] In a preferred scheme, the aforementioned rotating structure includes a manual rotating structure and an electric rotating structure. The manual rotating structure includes a main handle screw fixing block, a main handle stirring screw, a main handle, a positioning column, and a positioning hole. The main handle screw fixing block is fixed on the upper plate body. The main handle stirring screw is connected with the syringe piston fixing block structure through the main handle screw fixing block by screwing. The main handle is integrally connected with the main handle stirring screw for rotation control. The positioning column is parallelly inserted into the positioning hole of the main handle screw fixing block through the round hole on the main handle to position the rotation degree of the main handle. Among them, the main handle has four protruding cylinders as hand holding points during rotation. The four protruding cylinders are located on one side of the semicircle to reduce the influence on the operation of the middle plate body structure. The motor rotating structure includes a stepping motor, a controller, a motor stirring screw, a power supply, a motor driver, a timer, and a PCB circuit board. The stepping motor, the controller, the power supply, the motor driver, and the timer are fixed on the upper plate body. They are protected by a circular arc plastic cover fixed on the upper plate body, which only exposes the controller panel. The stepping motor controls the rotation of the motor stirring screw, which is connected with the syringe piston fixing block structure. The instrument socket is connected with the stepping motor through a wire. The power socket is connected with a 220V indoor power supply and a power switch through a wire with a plug. The power switch is connected with the power supply through a PCB circuit board. The power supply provides 24V DC voltage and 10A rated current, and is connected with the stepping motor, the motor driver, the timer, and the controller through the PCB circuit board.

[0031] In a preferred embodiment, the aforementioned middle plate body structure comprises a middle plate body, a flat push plate, a flat push plate handle, a sample vial plate stopper, a side plate moving track, a sample vial plate, a sample vial hole, a left plate body, a right plate body, a gasket, a gasket handle, a gasket drawer, a waste tank, a waste inlet hole, a waste tank valve, and the two sides of the middle plate body are fixedly connected with the left plate body and the right plate body, and are fixedly connected with the upper plate body structure and the lower plate body structure through the left plate body and the right plate body, and each of the left plate body and the right plate body has a side plate moving track for providing a fixed track of the flat push plate and determining the specified position of the flat push plate during operation, the sample vial plate stopper on the flat push plate can exactly place the sample vial plate, the sample vial hole on the sample vial plate can exactly place the sample vial for high performance liquid chromatography, the flat push plate handle is used for pushing and pulling and assisting in lifting the flat push plate, the gasket is used for fixing the height of the flat push plate during use, so that the bottom of the filter head can be exactly located at the mouth of the sample vial, the gasket handle is used for sending and pulling out the gasket, and the gasket drawer is used for temporarily storing the gasket. The waste tank is fixed on the lower side of the middle plate body, receives the primary filtrate that needs to be discarded through the waste inlet hole, and the waste tank valve can save and discharge the waste liquid by opening and closing. The number of sample vial holes is consistent with the number of injectors that can be installed at most; the two ends of the flat push plate are clamped in the side plate moving track through two small square column bodies and can move freely, and the distance between the two small square column bodies on each side is consistent with the distance between the two upward cuboids in the side plate moving track.

[0032] In a preferred embodiment, the aforementioned lower plate body structure comprises a lower plate body, a table surface fixing hole, a side fixing block connecting hole, a table surface fixing screw, a front fixing block, a front fixing hole, a side fixing block, a side fixing hole, and a fixing block screw, and the surface of the lower plate body has 2-6 table surface fixing holes which can be fixed to the experimental table surface through the table surface fixing screw to fix the dissolution instrument semi-automatic sampler; each side of the lower plate body has 2-4 side fixing block connecting holes which can pass through the side fixing hole through the fixing block screw to connect and stabilize the side fixing block, and the inner side of the lower plate body has 4-10 front fixing block connecting holes which can pass through the front fixing hole through the fixing block screw to connect and stabilize 2-5 front fixing blocks.

[0033] In a further preferred embodiment, the total number of injectors that can be fixed on the aforementioned injector cylinder fixing block structure is 4-30, and the preferred number of injectors is 12 which can be used for 6, 8 and 12 dissolution cups; the size of the injector is a standard 2mL, 3mL, 5mL, 10mL, 20mL, 50mL, 100mL injector, and the preferred size of the sampling and liquid supplementing injector is a standard 5mL or 10mL injector; the multi-channel valve connection structure is preferably an insertion type multi-channel valve connection structure with close connection of each channel during operation, less risk of liquid leakage and cross contamination.

[0034] The above-mentioned stepping motor can be selected as a 56BYG250CK type stepping motor, which can be directly purchased in the network or market, and its working principle is well known to those skilled in the art, which will not be described here.

[0035] The above-mentioned dissolution tester automatic sampler with the plug-in multi-channel valve bank structure, the pull-out multi-channel valve bank structure or the rotary multi-channel valve bank structure can be detachably connected with the existing dissolution tester sampling pipeline and dissolution cup, such as the RT612 type of Sharp, the RC12ADK type of Tianda Tianfa, the FADT-800RC / 1200RC type of Fuxikesi, the 708-DS type of Agilent, the Vision G2 Elite8 type of Hanson, the Model 2500 type of Distek, the UDT-818A-12 type of Logan dissolution tester, etc.

[0036] The application also provides a sampling method used with the above-mentioned dissolution tester semi-automatic sampler:

[0037] Before the operation of the three multi-channel valve bank structures corresponding to the dissolution tester semi-automatic sampler begins, the lower plate body structure is stably installed on the experimental table by being directly fixed to the table top or through a fixing block. The syringe is inserted into the syringe cylinder hole, so that the syringe cylinder handle is clamped at the cylinder fixing block syringe cylinder handle clamping point, the cylinder fixing block long column and the syringe cylinder clamping block plate are respectively installed and tightened to fix the position of the syringe. The syringe piston inserted from the cylinder fixing block syringe piston handle hole is inserted into the piston fixing block syringe piston handle clamping point, and the piston fixing block long column is installed and tightened to fix the position of the syringe piston. The pipeline and plug of the plug-in multi-channel valve bank structure and the syringe cylinder fixing block structure are connected, and a disposable needle filter is installed. The flat push plate of the middle plate body structure is kept in a position not covering the waste liquid inlet hole, the waste liquid tank valve is closed, the sample vial is placed in the sample vial hole, and the sample vial plate is placed in the sample vial plate clamping position. The position of the main handle of the manual rotation structure and the positioning column is adjusted or the circuit of the motor rotation structure is checked, the power supply is connected, and the switch is turned on. At the same time, sufficient medium of appropriate temperature and correctly placed liquid supplement pipeline are ensured.

[0038] For the dissolution apparatus semi-automatic sampler equipped with plug-in multi-channel valve bank structure, including the following steps: the needle filter is fixed under the column head of the plug-in multi-channel valve conversion block, the straight pipe plug of the plug moving block is checked in the sampling corresponding channel of the plug-in multi-channel valve conversion block. After the temperature of the medium in the dissolution cup and the medium to be supplemented reaches the requirement, the drug is administered according to the operation procedure of the dissolution apparatus used. 20 seconds before each sampling time, rotate the main handle of the manual rotation structure or start the motor rotation structure sampling program to take sample (the dissolution medium is also sucked into the corresponding syringe), and immediately return the extracted liquid to the dissolution cup to wet the pipeline. Then rotate the main handle of the manual rotation structure or start the motor rotation structure sampling program to take sample again, immediately move the straight pipe plug of the plug moving block to the corresponding channel of the plug-in multi-channel valve conversion block, and rotate the main handle of the manual rotation structure or start the motor rotation structure to supplement the liquid (the liquid is also discharged). Among them, the collected liquid in the supplementing process is first discarded to the waste liquid tank of the middle plate body structure according to the specified volume required by the experiment, after the discarding is completed, immediately push the flat plate inward to the bottom, and use the gasket to lift the flat plate to the specified position. Then the liquid in the syringe is injected into the sample vial (at the same time, the dissolution medium is injected into the dissolution cup), after the collected solution in the sample vial reaches the appropriate volume, the gasket is pulled out, the flat plate is moved outward, the remaining liquid is injected into the waste liquid tank of the middle plate body structure (at the same time, the remaining dissolution medium is injected into the dissolution cup), the sample vial is taken out from the sample vial plate, the cap is screwed on, and a new sample vial is put in. The straight pipe plug of the plug moving block is placed in the sampling corresponding channel of the plug-in multi-channel valve conversion block, and after the position is determined, the sampling operation at the next time point is prepared. Repeat the above operation for each sampling until the sampling experiment is completed.

[0039] After the experiment is completed, the pipeline and syringe are cleaned with purified water (whether to take out the syringe for re-cleaning or replacement is determined according to the situation). Put the gasket into the gasket drawer, if the motor rotation structure is used, turn off the power switch and pull out the power plug.

[0040] For dissolution apparatus semi-automatic sampler equipped with pull-type multi-channel valve connection structure, including the following steps: the needle filter is fixed under the column head of the pull-type multi-channel valve, and the positioning plug of the pull-type central shaft and the channel of the outer frame body is determined at the corresponding position of sampling. After the temperature of the medium in the dissolution cup and the medium to be supplemented reaches the required temperature, the medicine is administered according to the operation program of the dissolution apparatus used. 20 seconds before each sampling time, rotate the main handle of the manual rotation structure or start the motor rotation structure sampling program to sample (the dissolution medium is also sucked into the corresponding syringe), and immediately return the extracted liquid to the dissolution cup to wet the pipeline. Then rotate the main handle of the manual rotation structure or start the motor rotation structure sampling program to sample again, remove the positioning plug, pull the pull-type central shaft through the pull-type central shaft handle, so that the pull-type central shaft and the channel of the outer frame body are at the corresponding position of the liquid supplement, and the positioning plug is placed again. Rotate the main handle of the manual rotation structure or start the motor rotation structure liquid supplement program to supplement liquid (the liquid is also discharged at the same time). Among them, the liquid collected during the liquid supplement process is first discarded to the waste liquid tank of the middle plate structure according to the specified volume required by the experiment, and after the discarding is completed, immediately push the flat plate inward to the bottom, and use the gasket to lift the flat plate to the specified position. Immediately, the liquid in the syringe is injected into the sample vial (at the same time, the dissolution medium is injected into the dissolution cup), and after the solution collected in the sample vial reaches the appropriate volume, the gasket is pulled out, the flat plate is moved outward, the remaining liquid is discharged to the waste liquid tank of the middle plate structure (at the same time, the remaining dissolution medium is discharged into the dissolution cup), the sample vial is taken out from the sample vial plate, the cap is screwed on, and a new sample vial is placed. Remove the positioning plug, push the pull-type central shaft through the pull-type central shaft handle, so that the pull-type central shaft and the channel of the outer frame body are at the corresponding position of sampling, and the positioning plug is placed again. After the position is determined, prepare for the sampling operation at the next time point. Repeat the above operation for each sampling until the sampling experiment is completed.

[0041] After the experiment is completed, the pipeline and syringe are cleaned with purified water (whether to remove the syringe for re-cleaning or replacement is determined according to the situation). Put the gasket into the gasket drawer, if the motor rotation structure is used, turn off the power switch and unplug the power plug.

[0042] For the dissolution apparatus semi-automatic sampler equipped with rotary multi-channel valve bank structure, comprising the following steps: fixing the needle filter under the column head of the rotary multi-channel valve rotary body, checking all the rotary body rods in the corresponding positions of the rotary body rod fixed groove. After the temperature of the medium in the dissolution cup and the medium to be supplemented reaches the required temperature, the drug is administered according to the operation procedure of the dissolution apparatus used. 20 seconds before each sampling time, rotate the main handle of the manual rotation structure or start the motor rotation structure sampling program to sample (the dissolution medium is also sucked into the corresponding syringe), and immediately return the sampled liquid to the dissolution cup to wet the pipeline. Then rotate the main handle of the manual rotation structure or start the motor rotation structure sampling program to sample again, and immediately move the rotary body rod to the corresponding position of the rotary body rod fixed groove for liquid supplement. Rotate the main handle of the manual rotation structure or start the motor rotation structure liquid supplement program to supplement the liquid (the liquid is also discharged at the same time). Among them, the liquid collected during the liquid supplement process is first discarded to the waste liquid groove of the middle plate body structure according to the experimental requirements, and after the discarding is completed, the flat plate is immediately pushed inward to the bottom, and the flat plate is lifted to the specified position with a gasket. Then, the liquid in the syringe is injected into the sample vial (at the same time, the dissolution medium is injected into the dissolution cup), and after the solution collected in the sample vial reaches the appropriate volume, the gasket is pulled out, the flat plate is moved outward, the remaining liquid is injected into the waste liquid groove of the middle plate body structure (at the same time, the remaining dissolution medium is injected into the dissolution cup), the sample vial is taken out from the sample vial plate, the cap is screwed on, and a new sample vial is placed. Move the rotary body rod to the corresponding position of the rotary body rod fixed groove for sampling. After the position is determined, prepare for the sampling operation at the next time point. Repeat the above operation for each sampling until the sampling experiment is completed.

[0043] After the experiment is completed, the pipeline and syringe are cleaned with purified water (whether to remove the syringe for re-cleaning or replacement is determined according to the situation). Put the gasket into the gasket drawer, and if the motor rotation structure is used, turn off the power switch and unplug the power plug.

[0044] Compared with the existing manual sampling method and dissolution apparatus automatic sampling device, the multi-channel valve bank structure used for sampling and the dissolution apparatus semi-automatic sampler of the present application have the following advantages:

[0045] A. Compared with the manual sampling method, only one person is needed to complete the entire experimental operation, and the sampling time interval between dissolution cups can be significantly reduced, which facilitates synchronous sampling and reduces human bias.

[0046] B. Compared with the dissolution apparatus automatic sampling device, the instrument structure and principle are simple, the cost is low, it is easy to popularize, the dead volume of the sampling pipeline is small, and the liquid can be directly injected into the sample vial.

[0047] C. The piston system selects a syringe, which is easy to clean, replace and select specifications.

[0048] The dissolution tester automatic sampling device of the present application can switch the multi-channel valve group, so that different branches are communicated with the common channel, thereby realizing the communication of the power pump with the corresponding pipeline under different conditions, and quickly and accurately completing the automatic sampling, automatic liquid supplementing, automatic pipeline emptying, automatic pipeline cleaning and other operations in the automatic sampling process of the dissolution experiment, meeting the sampling requirements of the pharmacopoeia for the dissolution experiment, achieving accurate, reliable and efficient sampling, and avoiding the pollution of adjacent sampling points to the sample. BRIEF DESCRIPTION OF DRAWINGS

[0049] In order to make the purpose, technical scheme and beneficial effects of the present application more clear, the present application provides the following drawings:

[0050] Figure 1 The plan view of the plug-in multi-channel valve bank structure of the present application

[0051] Figure 2 The fixed block structure schematic diagram of the plug-in multi-channel valve bank structure of the present application

[0052] Figure 3 The front view schematic diagram of the plug-in multi-channel valve bank structure of the present application

[0053] Figure 4 The back view schematic diagram of the plug-in multi-channel valve bank structure of the present application

[0054] Figure 5 The front view schematic diagram of the plug-in multi-channel valve bank structure of the present application

[0055] Figure 6 The back view schematic diagram of the plug-in multi-channel valve bank structure of the present application

[0056] Figure 7 The internal channel structure schematic diagram of the plug-in multi-channel valve bank structure of the present application

[0057] Figure 8 The front view schematic diagram of the outer frame structure of the pull-out multi-channel valve bank structure of the present application

[0058] Figure 9 The back view schematic diagram of the outer frame structure of the pull-out multi-channel valve bank structure of the present application

[0059] Figure 10 The front view schematic diagram of the pull-out multi-channel valve bank structure of the present application

[0060] Figure 11Figure 9 is a back view of the pull-out central shaft structure of the pull-out multi-channel valve bank structure of the present application

[0061] Figure 12 Figure 10 is a schematic view of the internal channel of the pull-out central shaft structure of the pull-out multi-channel valve bank structure of the present application

[0062] Figure 13 Figure 11 is a schematic view of the rotating multi-channel valve block structure of the rotating multi-channel valve bank structure of the present application

[0063] Figure 14 Figure 12 is a front view of the rotating multi-channel valve block structure of the rotating multi-channel valve bank structure of the present application

[0064] Figure 15 Figure 13 is a back view of the rotating multi-channel valve block structure of the rotating multi-channel valve bank structure of the present application

[0065] Figure 16 Figure 14 is a schematic view of the multi-channel valve rotating body and its internal channel structure of the rotating multi-channel valve bank structure of the present application

[0066] Figure 17 Figure 15 is a schematic view of the manual rotating type dissolution tester automatic sampling device of the present application

[0067] Figure 18 Figure 16 is a front view of the syringe cylinder fixing block structure of the dissolution tester automatic sampling device of the present application

[0068] Figure 19 Figure 17 is a back view of the syringe cylinder fixing block structure of the dissolution tester automatic sampling device of the present application

[0069] Figure 20 Figure 18 is a schematic view of the syringe piston fixing block structure of the dissolution tester automatic sampling device of the present application

[0070] Figure 21 Figure 19 is a schematic view of the upper plate body structure of the dissolution tester automatic sampling device of the present application

[0071] Figure 22 Figure 20 is a schematic view of the manual rotating structure of the dissolution tester automatic sampling device of the present application

[0072] Figure 23 Figure 21 is a schematic view of the motor rotating structure of the dissolution tester automatic sampling device of the present application

[0073] Figure 24 Figure 22 is a schematic view of the middle plate body structure of the dissolution tester automatic sampling device of the present application

[0074] Figure 25 Figure 23 is a schematic view of the waste liquid tank structure of the middle plate body structure of the dissolution tester automatic sampling device of the present application

[0075] Figure 26 Structure diagram of the lower plate body of the automatic sampling device of the dissolution tester of the present application

[0076] Figure 27 Structure diagram of the fixed block connected with the lower plate body of the automatic sampling device of the dissolution tester of the present application

[0077] In the figure: 1 plug-in multi-channel valve row structure: 1-1 rotating screw, 1-2 rotating screw fixed block, 1-3 chain, 1-4 columnar synchronous shaft, 1-5 plug moving block, 1-6 columnar synchronous shaft sleeve, 1-7 straight pipe plug, 1-8 fixed bottom plate, 1-9 plug-in multi-channel valve conversion block, 1-10 rotating screw fixed block moving boundary, 1-11 rotating screw fixed block bottom sheet moving boundary, 1-12 plug moving block moving boundary, 1-13 plug moving block bottom sheet moving boundary, 1-14 rotating screw fixed block bottom sheet, 1-15 rotating screw fixed block bearing cavity, 1-16 plug moving block bottom sheet, 1-17 plug moving block threaded cavity, 1-18 plug moving block hose, 1-19 plug-in multi-channel valve conversion block lower column head, 1-20 plug-in multi-channel valve conversion block hose, 1-21 plug-in upper straight channel, 1-22 plug-in lower straight channel, 1-23 plug-in upper curved channel, 1-24 plug-in lower curved channel; 2 pull-out multi-channel valve row structure: 2-1 outer frame, 2-2 positioning plug block, 2-3 outer frame positioning square hole, 2-4 middle square hole, 2-5 outer frame channel, 2-6 pull-out multi-channel valve lower column head, 2-7 outer frame hose, 2-8 pull-out middle shaft, 2-9 middle shaft liquid supplement positioning square hole, 2-10 middle shaft sampling positioning square hole, 2-11 pull-out middle shaft handle, 2-12 pull-out upper straight channel, 2-13 pull-out lower straight channel, 2-14 pull-out upper curved channel, 2-15 pull-out lower curved channel; 3 rotary multi-channel valve row structure: 3-1 multi-channel valve rotary body, 3-2 rotary multi-channel valve block, 3-3 rotary multi-channel valve block channel, 3-4 fixed plate, 3-5 rotary body rod fixed block, 3-6 cylindrical cavity, 3-7 fixed plate hole, 3-8 fixed plate screw, 3-9 rotary body rod position baffle, 3-10 rotary body rod fixed groove, 3-11 rotary upper straight channel, 3-12 rotary lower straight channel, 3-13 rotary upper curved channel, 3-14 rotary lower curved channel, 3-15 rotary body rod, 3-16 rotary multi-channel valve rotary body lower column head, 3-17 rotary multi-channel valve block hose, 3-18 upper cylindrical body, 3-19 lower cylindrical body; 4 syringe cylinder fixed block structure: 4-1 syringe cylinder fixed block, 4-2 cylinder fixed block long column fixed position, 4-3 cylinder fixed block long screw hole, 4-4 cylinder fixed block short screw hole, 4-5 cylinder fixed block syringe piston handle hole, 4-6 cylinder fixed block syringe cylinder handle clamp point, 4-7 cylinder fixed block short screw, 4-8 cylinder fixed block long column, 4-9 cylinder fixed block long column long screw hole, 4-10 cylinder fixed block long column short screw hole, 4-11 cylinder fixed block long column handle, 4-12 syringe cylinder hole, 4-13 cylinder clamp block plate fixed position, 4-14 syringe cylinder clamp block plate, 4-15 syringe cylinder clamp block column, 4-16 cylinder clamp long screw hole, 4-17 cylinder fixed block long screw.5 Syringe piston fixing block structure: 5-1 syringe piston fixing block, 5-2 piston fixing block long column fixing position, 5-3 piston fixing block bottom sliding body, 5-4 piston fixing block syringe piston handle hole, 5-5 piston fixing block syringe piston handle clamping point, 5-6 piston fixing block threaded cavity, 5-7 piston fixing block long column, 5-8 piston fixing block long column threaded cavity, 5-9 piston fixing block long column screw hole, 5-10 piston fixing block long column handle, 5-11 piston fixing block screw, 5-12 piston fixing block screw hole; 6 upper plate body structure: 6-1 upper plate body, 6-2 multi-channel valve group structure screw hole, 6-3 side handle screw fixing block, 6-4 side handle stirring screw, 6-5 side handle, 6-6 cylinder fixing block screw hole, 6-7 piston fixing block bottom sliding body clamping position; 7 manual rotation structure: 7-1 main handle screw fixing block, 7-2 main handle stirring screw, 7-3 main handle, 7-4 positioning column, 7-5 positioning hole; 8 motor rotation structure: 8-1 stepper motor, 8-2 controller, 8-3 motor stirring screw, 8-4 power supply, 8-5 motor driver, 8-6 timer, 8-7 PCB circuit board; 9 middle plate body structure: 9-1 middle plate body, 9-2 flat push plate, 9-3 flat push plate handle, 9-4 sample vial plate clamping position, 9-5 side plate moving track, 9-6 sample vial plate, 9-7 sample vial hole, 9-8 left plate body, 9-9 right plate body, 9-10 gasket, 9-11 gasket handle, 9-12 gasket drawer, 9-13 waste liquid tank, 9-14 waste liquid inlet hole, 9-15 waste liquid tank valve; 10 lower plate body structure: 10-1 lower plate body, 10-2 table fixed hole, 10-3 side fixing block connecting hole, 10-4 table fixed screw, 10-5 front fixing block, 10-6 front fixed hole, 10-7 side fixing block, 10-8 side fixed hole, 10-9 fixing block screw, 10-10 front fixing block connecting hole. DETAILED DESCRIPTION

[0078] The preferred embodiments of the present application will be described in detail below with reference to the accompanying drawings. Unless otherwise specified, the experimental methods in the examples are generally carried out according to conventional conditions or conditions recommended and regulated by similar instruments and pharmacopoeias, guidelines.

[0079] Example 1 A plug-in multi-channel valve group structure

[0080] As Figures 1 to 7As shown, the part provides a plug-in multi-channel valve row structure 1, which is composed of rotating screw fixing block structure, plug-in mobile block structure and plug-in multi-channel valve conversion block structure. Among them, the rotating screw fixing block structure includes rotating screw 1-1, rotating screw fixing block 1-2, chain 1-3, cylindrical synchronous shaft 1-4, rotating screw fixing block bearing cavity 1-15, rotating screw fixing block bottom sheet 1-14, which guarantees the forward and backward movement of plug-in mobile block structure by fixing the position of rotating screw 1-1; The plug-in mobile block structure includes plug-in mobile block 1-5, cylindrical synchronous shaft sleeve 1-6, straight pipe plug 1-7, fixed bottom plate 1-8, plug-in mobile block bottom sheet 1-16, plug-in mobile block threaded cavity 1-17, plug-in mobile block hose 1-18, which is used for conversion of the communication position of plug-in multi-channel valve conversion block structure by moving forward, backward, left and right; The plug-in multi-channel valve conversion block structure includes plug-in multi-channel valve conversion block 1-9, plug-in multi-channel valve conversion block lower column head 1-19, plug-in multi-channel valve conversion block hose 1-20, plug-in upper straight channel 1-21, plug-in lower straight channel 1-22, plug-in upper curved channel 1-23, plug-in lower curved channel 1-24, which is used for synchronous control of sampling, liquid supplementing and injecting through the internal pipeline system. The plug-in multi-channel valve conversion block 1-9 is directly fixed on the upper plate body 6-1, and the rotating screw fixing block 1-2 and the plug-in mobile block 1-5 are respectively embedded in the rotating screw fixing block moving boundary 1-10, the rotating screw fixing block bottom sheet moving boundary 1-11, the plug-in mobile block moving boundary 1-12 and the plug-in mobile block bottom sheet moving boundary 1-13 defined by the fixed bottom plate 1-8 of the upper plate body 6-1 through the rotating screw fixing block bottom sheet 1-14 and the plug-in mobile block bottom sheet 1-16.

[0081] Wherein, the rotating screw 1-1 passes through the rotating screw fixing block bearing cavity 1-15 containing threaded bearing and the plug moving block threaded cavity 1-17 containing threaded structure, adjusts the position of the cuboid solid plastic or metal rotating screw fixing block 1-2 and the plug moving block 1-5, and communicates the side handle stirring screw 6-4 through the chain 1-3 to obtain the moving power of the rotating screw fixing block 1-2 and the plug moving block 1-5. The cylindrical synchronous shaft 1-4 is inserted into the cylindrical synchronous shaft sleeve 1-6 to ensure the synchronous left and right movement of the rotating screw fixing block structure and the plug moving block structure. The straight pipe plug 1-7 can be tightly pushed into the upper straight channel 1-21, the lower straight channel 1-22, the upper curved channel 1-23 and the lower curved channel 1-24 as required to connect the sampling and liquid supplement channels of the plug-in multi-channel valve conversion block 1-9 respectively. The upper straight channel 1-21 is located directly above the lower straight channel 1-22, and the upper curved channel 1-23 is located directly above the lower curved channel 1-24. The plug-in multi-channel valve conversion block lower column head 1-19 is directly connected to the lower side of the lower curved channel 1-24, and the liquid medicine is injected into the sample vial through the needle filter. The plug-in multi-channel valve conversion block hose 1-20 connects the sampling needle and the liquid supplement needle of the dissolution instrument. When the syringe is connected to the upper straight channel 1-21 and the lower straight channel 1-22, the dissolution medium is sucked through the upper straight channel 1-21, and the liquid medicine in the dissolution cup is sucked through the lower straight channel 1-22; when the syringe is connected to the upper curved channel 1-23 and the lower curved channel 1-24, the dissolution medium is added to the dissolution cup through the upper curved channel 1-23, and the extracted liquid medicine is injected into the sample vial through the lower curved channel 1-24. The plug moving block hose 1-18 is connected with the syringe on the syringe cylinder fixing block structure 4 to ensure that the position of the syringe is not affected when the plug moving block 1-5 moves.

[0082] Wherein, the parameters of different components of the plug-in multi-channel valve array structure 1 are preferably as follows: the distance between the straight pipe plugs 1-7 is equal to the distance between the plug moving block hoses 1-18, and both are twice the distance between the channel structures composed of the upper straight channel 1-21 and the lower straight channel 1-22 and the channel structures composed of the upper curved channel 1-23 and the lower curved channel 1-24. The diameters of the upper straight channel 1-21, the lower straight channel 1-22, the upper curved channel 1-23 and the lower curved channel 1-24 are approximately equal to the outer diameter of the syringe nipple. The number of straight pipe plugs 1-7 is equal to the number of plug moving block hoses 1-18, and is equal to the number of channel structures composed of the upper straight channel 1-21 and the lower straight channel 1-22 and the number of channel structures composed of the upper curved channel 1-23 and the lower curved channel 1-24.

[0083] Example 2: A pull-out multi-channel valve array structure

[0084] As Figures 8 to 12 shown, this part provides a pull-out multi-channel valve bank structure 2, which is composed of an outer frame structure and a pull-out central shaft structure. Among them, the outer frame structure includes an outer frame 2-1, a positioning plug 2-2, an outer frame positioning square hole 2-3, a middle square hole 2-4, an outer frame channel 2-5, a pull-out multi-channel valve lower stem 2-6, an outer frame hose 2-7, which is used to adjust the flow of liquid and medium by fixing the pull-out central shaft structure and connecting the internal pipeline of the pull-out central shaft structure; the pull-out central shaft structure includes a pull-out central shaft 2-8, a central shaft liquid supplement positioning square hole 2-9, a central shaft sampling positioning square hole 2-10, a pull-out central shaft handle 2-11, a pull-out upper straight channel 2-12, a pull-out lower straight channel 2-13, a pull-out upper curved channel 2-14, and a pull-out lower curved channel 2-15, which are used to synchronously control the operations of sampling, liquid supplementing, and liquid injection through the internal pipeline system. The outer frame structure is directly fixed on the upper plate body 6-1 and accommodates and clamps the pull-out central shaft structure through the middle square hole 2-4.

[0085] Among them, the pull-out central shaft 2-8 has a layer of rubber plated on the two side walls of the pipeline opening, the position of the pull-out central shaft 2-8 in the outer frame 2-1 is moved by means of the pull-out central shaft handle 2-11, and then the pull-out central shaft 2-8 is clamped into the middle square hole 2-4 of the outer frame 2-1. The top end of the pull-out central shaft 2-8 is a semicircular spherical protrusion, which can be clamped into the same size semicircular spherical groove of the outer frame structure after insertion. The positioning plug 2-2 is clamped into the outer frame positioning square hole 2-3 and the central shaft sampling positioning square hole 2-10 / central shaft liquid supplement positioning square hole 2-9 to realize the conversion and fixation of the sampling and liquid supplementing positions. The pull-out upper straight channel 2-12 is located directly above the pull-out lower straight channel 2-13, the pull-out upper curved channel 2-14 is located directly above the pull-out lower curved channel 2-15, and the pull-out upper straight channel 2-12, the pull-out lower straight channel 2-13, the pull-out upper curved channel 2-14, and the pull-out lower curved channel 2-15 are connected to the outer frame channel 2-5. The outer frame channel 2-5 is connected to the syringe externally and to the sampling needle and the liquid supplementing needle of the dissolution instrument internally through the outer frame hose 2-7. The pull-out multi-channel valve lower stem 2-6 is directly connected to the lower side port of the pull-out lower curved channel 2-15 and injects the liquid into the sample vial through the needle filter.

[0086] In this pull-out multi-channel valve assembly structure 2, the preferred parameters for different components are as follows: the diameters of the pull-out upper straight channel 2-12, pull-out lower straight channel 2-13, pull-out upper curved channel 2-14, and pull-out lower curved channel 2-15 are all approximately the outer diameter of a syringe nipple; the number of outer frame hoses 2-7 is equal to the number of channel structures formed by the pull-out upper straight channel 2-12 and pull-out lower straight channel 2-13, or the number of channel structures formed by the pull-out upper curved channel 2-14 and pull-out lower curved channel 2-15. The number of lower column heads 2-6 of the pull-out multi-channel valve is half the number of outer frame hoses 2-7. The spacing between the outer frame channels 2-5 on the front and rear walls of the outer frame 2-1 is twice the spacing between the channel structures formed by the pull-out upper straight channel 2-12 and pull-out lower straight channel 2-13 and the channel structures formed by the pull-out upper curved channel 2-14 and pull-out lower curved channel 2-15.

[0087] Example 3: A rotary multi-channel valve row structure

[0088] like Figures 13 to 16 As shown, this section provides a rotary multi-channel valve assembly structure 3, which consists of a rotary multi-channel valve block structure and a multi-channel valve rotator 3-1. The rotary multi-channel valve block structure includes a rotary multi-channel valve block 3-2, a rotary multi-channel valve block channel 3-3, a fixing plate 3-4, a rotating rod fixing block 3-5, a cylindrical cavity 3-6, a fixing plate hole 3-7, a fixing plate screw 3-8, a rotating rod position baffle 3-9, a rotating rod fixing groove 3-10, and a rotary multi-channel valve block hose 3-17. These components, along with the internal pipes connecting the rotary multi-channel valve 3-1, are used to regulate the flow of the liquid and medium. The rotary multi-channel valve 3-1 includes an upper cylinder 3-18, a lower cylinder 3-19, a rotary upper straight channel 3-11, a rotary lower straight channel 3-12, a rotary upper curved channel 3-13, a rotary lower curved channel 3-14, a rotating rod 3-15, and a rotary multi-channel valve 3-channel lower column head 3-16. These components, through an internal piping system, are used to synchronously control sampling, replenishment, and injection operations. The rotary multi-channel valve block structure is directly fixed on the upper plate 6-1, and the multi-channel valve rotating body 3-1 is accommodated and clamped by the internal cylindrical cavity 3-6.

[0089] Wherein, the upper cylinder 3-18 of the multi-channel valve rotating body 3-1 is integrally connected with the lower cylinder 3-19 plated with a layer of rubber on the side surface, the rotating body rod 3-15 is fixed on the upper cylinder 3-18, the rotating body rod fixing groove 3-10 above the rotating body rod fixing block 3-5 accommodates the rotating body rod 3-15, the rotating body rod position baffle 3-9 on both sides ensures that the movable angle of the multi-channel valve rotating body 3-1 is 90°, and the lower part is provided with a spring that can smoothly push the rotating body rod 3-15 by pressing. The fixed plate screw 3-8 passes through the fixed plate hole 3-7 to fix the fixed plate 3-4 on the rotary multi-channel valve block 3-2 and cover the multi-channel valve rotating body 3-1. In the same multi-channel valve rotating body 3-1, the rotary upper straight channel 3-11 is located directly above the rotary lower straight channel 3-12, and the rotary upper curved channel 3-13 is located directly above the rotary lower curved channel 3-14. The channel structure composed of the rotary upper straight channel 3-11 and the rotary lower straight channel 3-12 is arranged in a vertical non-intersecting manner with the channel structure composed of the rotary upper curved channel 3-13 and the rotary lower curved channel 3-14. The rotary upper straight channel 3-11, the rotary lower straight channel 3-12, the rotary upper curved channel 3-13, and the rotary lower curved channel 3-14 are connected to the rotary multi-channel valve block channel 3-3, and the rotary multi-channel valve block hose 3-17 is connected to the sampling needle and the liquid supplementing needle of the dissolution tester. The rotary multi-channel valve rotating body lower column head 3-16 is connected to the rotary lower curved channel 3-14 upward, penetrates the rotary multi-channel valve block structure 3 bottom hole downward, and injects the liquid into the sample vial through the needle filter.

[0090] Wherein, the parameters of different components of the rotary multi-channel valve block structure 3 are preferably as follows: the diameters of the rotary upper straight channel 3-11, the rotary lower straight channel 3-12, the rotary upper curved channel 3-13, and the rotary lower curved channel 3-14 are approximately equal to the outer diameter of the syringe nipple. The number of channel structures composed of the rotary upper straight channel 3-11 and the rotary lower straight channel 3-12 is equal to the number of channel structures composed of the rotary upper curved channel 3-13 and the rotary lower curved channel 3-14. The number of rotary multi-channel valve block channels 3-3 on the front wall of the rotary multi-channel valve block 3-2 is equal to the sum of the number of rotary multi-channel valve block hoses 3-17 connected to the rear wall and the number of rotary multi-channel valve rotating body lower column heads 3-16.

[0091] Example 4: A dissolution tester semi-automatic sampler

[0092] As shown in Figures 17 to 27 , this part provides a dissolution tester semi-automatic sampler carrying the multi-channel valve block structure shown in examples 1, 2, and 3. As shown in Figure 17As shown, the dissolution tester semi-automatic sampler includes a syringe cylinder fixed block structure 4, a syringe piston fixed block structure 5, an upper plate body structure 6, a rotating structure, a middle plate body structure 9, a lower plate body structure 10, and the multi-channel valve array structure shown in Embodiment 1, Embodiment 2, and Embodiment 3. Among them, the upper plate body structure 6 and the lower plate body structure 10 are fixed on the upper and lower sides of the middle plate body 9-1 through the left plate body 9-8 and the right plate body 9-9 on both sides of the middle plate body 9. The multi-channel valve array structure is directly fixed on the upper plate body 6-1, and is connected with the syringe cylinder fixed block structure 4 and the syringe piston fixed block structure 5 fixed on the upper plate body 6-1 respectively. The rotating structure is on the outer side of the upper plate body structure 6 and is connected with the syringe piston fixed block structure 5.

[0093] As shown in Figure 18 and Figure 19 , the syringe cylinder fixed block structure 4 is composed of a syringe cylinder fixed block 4-1, a cylinder fixed block long column fixed position 4-2, a cylinder fixed block long screw hole 4-3, a cylinder fixed block short screw hole 4-4, a cylinder fixed block syringe piston handle hole 4-5, a cylinder fixed block syringe cylinder handle clamp point 4-6, a cylinder fixed block short screw 4-7, a cylinder fixed block long column 4-8, a cylinder fixed block long column long screw hole 4-9, a cylinder fixed block long column short screw hole 4-10, a cylinder fixed block long column handle 4-11, a syringe cylinder hole 4-12, a cylinder clamp block plate fixed position 4-13, a syringe cylinder clamp block plate 4-14, a syringe cylinder clamp block column 4-15, a cylinder clamp block long screw hole 4-16, a cylinder fixed block long screw 4-17. The syringe cylinder penetrates the syringe cylinder fixed block 4-1 through the syringe cylinder hole 4-12, the syringe cylinder handle is clamped at the cylinder fixed block syringe cylinder handle clamp point 4-6, and the syringe piston protrudes from the cylinder fixed block syringe piston handle hole 4-5 into the cylinder fixed block syringe cylinder handle clamp point 4-6. After the syringe is put in, the cylinder fixed block long column 4-8 with a semispherical convex on the opposite side is inserted into the cylinder fixed block long column fixed position 4-2 with a semispherical recess by means of the cylinder fixed block long column handle 4-11, and the cylinder fixed block short screw 4-7 is screwed into the cylinder fixed block long column short screw hole 4-10 and the cylinder fixed block short screw hole 4-4 in turn to fix the cylinder fixed block long column 4-8, the other side of the syringe cylinder fixed block 4-1 puts the syringe cylinder clamp block plate 4-14 with the syringe cylinder clamp block column 4-15 into the cylinder clamp block plate fixed position 4-13, and the cylinder fixed block long screw 4-17 is screwed into the cylinder fixed block long column long screw hole 4-9, the cylinder clamp block long screw hole 4-16, and the cylinder fixed block long screw hole 4-3 in turn to integrally fix the cylinder fixed block long column 4-8 and the syringe cylinder clamp block.

[0094] As shown in Figure 20As shown, the injector piston fixed block structure 5 is composed of the injector piston fixed block 5-1, the piston fixed block long column fixed point 5-2, the piston fixed block bottom sliding body 5-3, the piston fixed block injector piston handle hole 5-4, the piston fixed block injector piston handle clamping point 5-5, the piston fixed block threaded cavity 5-6, the piston fixed block long column 5-7, the piston fixed block long column threaded cavity 5-8, the piston fixed block long column screw hole 5-9, the piston fixed block long column handle 5-10, the piston fixed block screw 5-11, and the piston fixed block screw hole 5-12. The injector piston enters the piston fixed block injector piston handle clamping point 5-5 through the piston fixed block long column fixed point 5-2, the piston column body passes through the piston fixed block injector piston handle hole 5-4, and the piston handle is clamped into the piston fixed block injector piston handle clamping point 5-5. After the injector piston enters the injector piston fixed block 5-1, the piston fixed block long column 5-7 with a semicircular spherical protrusion on the opposite side is inserted into the piston fixed block long column fixed point 5-2 with a semicircular spherical groove by means of the piston fixed block long column handle 5-10, and the piston fixed block screw 5-11 is screwed into the piston fixed block long column screw hole 5-9 and the piston fixed block screw hole 5-12 in turn. The manual rotation structure 7 or the motor rotation structure 8 is manually rotated to stir the screw 7-2 or the motor to stir the screw 8-3, which is screwed into the piston fixed block threaded cavity 5-6 and the piston fixed block long column threaded cavity 5-8 in turn to enable the injector piston fixed block structure 5 to move forward and backward. The piston fixed block bottom sliding body 5-3 is clamped in the piston fixed block bottom sliding body clamping point 6-7 of the upper plate body structure 6 to maintain the direction and stability of the movement of the injector piston fixed block structure 5.

[0095] As shown, Figure 21 The upper plate body structure 6 includes the upper plate body 6-1, the multi-channel valve group structure screw hole 6-2, the side handle screw fixed block 6-3, the side handle stirring screw 6-4, the side handle 6-5, the cylinder fixed block screw hole 6-6, and the piston fixed block bottom sliding body clamping point 6-7. The protruding rectangular body on the outside of the upper plate body 6-1 is used to fix the mobile phone rotation structure or the motor rotation structure 8, and the inward piston fixed block bottom sliding body clamping point 6-7 can exactly clamp the piston fixed block bottom sliding body 5-3. The cylinder fixed block screw hole 6-6 provides the position for fixing the injector cylinder fixed block structure 4 on the upper plate body structure 6, and the multi-channel valve group structure screw hole 6-2 provides the position for fixing the plug-in multi-channel valve group structure 1, the pull-out multi-channel valve group structure 2, or the rotary multi-channel valve group structure 3 on the upper plate body structure 6. The side handle screw fixed block 6-3 is fixed on the right side of the upper plate body 6-1, the side handle stirring screw 6-4 integrated with the side handle 6-5 is fixedly connected with the bearing in the side handle screw fixed block 6-3, and the side handle stirring screw 6-4 is also connected with the chain 1-3 of the plug-in multi-channel valve group structure 1 to drive the rotation screw 1-1 of the plug-in multi-channel valve group structure 1.

[0096] AsFigure 22 and Figure 23 As shown in the figure, the rotating structure includes a manual rotating structure 7 and an electric rotating structure. The manual rotating structure 7 is composed of a main handle screw fixing block 7-1, a main handle stirring screw 7-2, a main handle 7-3, a positioning column 7-4, and a positioning hole 7-5. The main handle stirring screw 7-2 is connected with the syringe piston fixing block structure 5 through the thread of the main handle screw fixing block 7-1. The main handle 7-3 with four protruding cylinders is integrally connected with the main handle stirring screw 7-2. The positioning column 7-4 is horizontally clamped into the positioning hole 7-5 on the main handle screw fixing block 7-1 through the round hole on the main handle 7-3 to fix the rotating degree of the main handle 7-3. The motor rotating structure 8 is composed of a stepping motor 8-1, a controller 8-2, a motor stirring screw 8-3, a power supply 8-4, a motor driver 8-5, a timer 8-6, and a PCB circuit board 8-7. The stepping motor 8-1, the controller 8-2, the power supply 8-4, the motor driver 8-5, and the timer 8-6 are respectively fixed on the upper plate body 6-1. The stepping motor 8-1 is connected with the motor stirring screw 8-3, and the motor stirring screw 8-3 is connected with the syringe piston fixing block structure 5. The instrument socket is connected with the stepping motor 8-1 through the wire. The power socket is connected with the 220V indoor power supply and a power switch through the wire with a plug. The power switch is connected with the power supply 8-4 to provide 24V direct current voltage and 10A rated current through the PCB circuit board 8-7, and is connected with the stepping motor 8-1, the motor driver 8-5, the timer 8-6, and the controller 8-2 through the PCB circuit board 8-7.

[0097] As Figure 24 and Figure 25As shown, the middle plate body structure 9 includes middle plate body 9-1, flat push plate 9-2, flat push plate handle 9-3, sample vial plate stop 9-4, side plate moving track 9-5, sample vial plate 9-6, sample vial hole 9-7, left plate body 9-8, right plate body 9-9, gasket 9-10, gasket handle 9-11, gasket drawer 9-12, waste tank 9-13, waste inlet hole 9-14, waste tank valve 9-15. The middle plate body 9-1 is connected to the left plate body 9-8 and the right plate body 9-9 on both sides, each with a side plate moving track 9-5. The sample vial plate 9-6 is placed on the sample vial plate stop 9-4 of the flat push plate 9-2, which is pushed and pulled by the flat push plate handle 9-3 and assisted to lift. The sample vial hole 9-7 on the sample vial plate 9-6 can be placed into the sample vial for high performance liquid chromatography. The gasket 9-10 is sent in and out by the gasket handle 9-11 to fix the height of the flat push plate 9-2 in use, and the gasket drawer 9-12 is used to temporarily store the gasket 9-10. The waste tank 9-13 is fixed on the lower side of the middle plate body 9-1, which receives the primary filtrate that needs to be discarded through the waste inlet hole 9-14, and the waste tank valve 9-15 saves and discharges the waste liquid by switching. Among them, the number of sample vial holes 9-7 is consistent with the number of syringes that can be installed at most, and the distance between the two small square columns at both ends of the flat push plate 9-2 is consistent with the distance between the two upward cuboids in the side plate moving track 9-5.

[0098] As shown in Figure 26 and Figure 27 As shown, the lower plate body structure 10 includes lower plate body 10-1, table surface fixing hole 10-2, side fixing block connecting hole 10-3, table surface fixing screw 10-4, front fixing block 10-5, front fixing hole 10-6, side fixing block 10-7, side fixing hole 10-8, fixing block screw 10-9. The lower plate body 10-1 has 2-6 table surface fixing holes 10-2 on the surface for fixing to the experimental table surface through the table surface fixing screw 10-4, and the lower plate body 10-1 has 2-4 side fixing block connecting holes 10-3 on both sides for connecting and stabilizing the side fixing block 10-7 by passing through the side fixing hole 10-8 with the fixing block screw 10-9, and the lower plate body 10-1 has 4-10 front fixing block connecting holes 10-10 on the inner side for connecting and stabilizing 2-5 front fixing blocks 10-5 by passing through the front fixing hole 10-6 with the fixing block screw 10-9.

[0099] Among them, the preferred parameters of different components of the dissolution instrument semi-automatic sampler are: the number of syringes that can be fixed on the syringe cylinder fixing block structure 4 is 12, which can be used for 6, 8 and 12 dissolution cups, and the size of the syringe is standard 5mL or 10mL syringe.

[0100] The present application uses the plug-in multi-channel valve bank structure 1, the pull-out multi-channel valve bank structure 2 or the rotary multi-channel valve bank structure 3 of the plug-in multi-channel valve conversion block hose 1-20, the outer frame body hose 2-7 or the rotary multi-channel valve block hose 3-17 of the plug-in multi-channel valve bank structure 1, the pull-out multi-channel valve bank structure 2 or the rotary multi-channel valve bank structure 3 in the dissolution tester automatic sampler, and the sampling pipeline and dissolution cup of the existing dissolution tester such as Sharp RT612 type, Tianda Tianfa RC12ADK type, Fukesi FADT-1200RC type, Agilent 708-DS type, Hanson Vision G2 Elite 8 type, Logan UDT-818A-12 type dissolution tester can be detachably connected.

[0101] The present application also provides a sampling method used with the above dissolution tester semi-automatic sampler:

[0102] Before the operation of the three multi-channel valve bank structures corresponding to the dissolution tester semi-automatic sampler begins, the lower plate body structure 10 is stably installed on the experimental table by being directly fixed to the table top or through a fixing block. The syringe is inserted into the syringe cylinder hole 4-12, so that the syringe cylinder handle is clamped in the cylinder fixing block syringe cylinder handle clamp point 4-6, and the cylinder fixing block long column 4-8 and the syringe cylinder clamp block plate 4-14 are respectively installed and tightened to fix the position of the syringe. The syringe piston inserted from the cylinder fixing block syringe piston handle hole 4-5 is inserted into the piston fixing block syringe piston handle clamp point 5-5, and the piston fixing block long column 5-7 is installed and tightened to fix the position of the syringe piston. The pipeline and plug of the plug-in multi-channel valve bank structure 1 and the syringe cylinder fixing block structure 4 are connected, and a disposable needle filter is installed. Keep the flat plate 9-2 of the middle plate body structure 9 in a position not covering the waste liquid inlet hole 9-14, close the waste liquid tank valve 9-15, put the sample vial into the sample vial hole 9-7, and put the sample vial plate 9-6 into the sample vial plate clamping position 9-4. Adjust the position of the main handle 7-3 and the positioning column 7-4 of the manual rotation structure 7 or check the circuit of the motor rotation structure 8, connect the power supply, and turn on the switch. At the same time, ensure sufficient medium of appropriate temperature and correctly placed liquid supplement pipeline.

[0103] When using the dissolution tester semi-automatic sampler, such as installing and using the plug-in multi-channel valve bank structure 1 of embodiment 1, the operation steps are as follows:

[0104] The needle filter is fixed under the plug-in multi-channel valve conversion block 1-19, and the straight pipe plug 1-7 of the plug moving block 1-5 is checked in the sampling corresponding channel of the plug-in multi-channel valve conversion block 1-9. After the temperature of the medium in the dissolution cup and the medium to be supplemented reaches the required temperature, the drug is administered according to the operation procedure of the dissolution tester used. 20 seconds before each sampling time, rotate the main handle 7-3 of the manual rotation structure 7 or start the motor rotation structure 8 sampling program to sample (the dissolution medium is also sucked into the corresponding syringe at the same time), and immediately return the extracted liquid to the dissolution cup to wet the pipeline. Then rotate the main handle 7-3 of the manual rotation structure 7 or start the motor rotation structure 8 sampling program to sample again, immediately move the straight pipe plug 1-7 of the plug moving block 1-5 to the corresponding channel of the plug-in multi-channel valve conversion block 1-9, and rotate the main handle 7-3 of the manual rotation structure 7 or start the motor rotation structure 8 to supplement the liquid (the liquid is also discharged at the same time). Among them, the liquid collected during the supplementing process is first discarded to the waste liquid tank 9-13 of the middle plate structure 9 according to the experimental requirements, after the discarding is completed, immediately push the flat plate 9-2 inward to the bottom, and use the gasket 9-10 to lift the flat plate 9-2 to the specified position. Then, the liquid in the syringe is injected into the sample vial (at the same time, the dissolution medium is injected into the dissolution cup), after the solution collected in the sample vial reaches the appropriate volume, the gasket 9-10 is pulled out, the flat plate 9-2 is moved outward, the remaining liquid is injected into the waste liquid tank 9-13 of the middle plate structure 9 (at the same time, the remaining dissolution medium is injected into the dissolution cup), the sample vial is taken out from the sample vial plate 9-6, the cap is screwed on, and a new sample vial is put in. The straight pipe plug 1-7 of the plug moving block 1-5 is placed in the sampling corresponding channel of the plug-in multi-channel valve conversion block 1-9, and after the position is determined, the sampling operation at the next time point is prepared. Repeat the above operation for each sampling until the sampling experiment is completed.

[0105] After the experiment is completed, the pipeline and syringe are cleaned with purified water (whether to take out the syringe for re-cleaning or replacement is determined according to the situation). Put the gasket 9-10 into the gasket drawer 9-12, if the motor rotation structure 8 is used, turn off the power switch and pull out the power plug.

[0106] When the dissolution tester semi-automatic sampler is used, if the pull-out multi-channel valve row structure 2 of Example 2 is installed and used, the operation steps are as follows:

[0107] The needle filter is fixed under the pull-type multi-channel valve 2-6, and the position of the pull-type central shaft 2-8 and the channel of the outer frame 2-1 is determined in the corresponding position of sampling by the positioning plug 2-2. After the temperature of the medium in the dissolution cup and the medium to be supplemented reaches the required temperature, the drug is administered according to the operation procedure of the dissolution tester used. 20 seconds before each sampling time, the main handle 7-3 of the manual rotating structure 7 is rotated or the motor rotating structure 8 is started to sample the program, and the sampling (the dissolution medium is also sucked into the corresponding syringe) is taken out immediately. The drug solution is immediately returned to the dissolution cup to wet the pipeline. Then the main handle 7-3 of the manual rotating structure 7 is rotated or the motor rotating structure 8 is started to sample the program, and the positioning plug 2-2 is taken out. The pull-type central shaft 2-8 is pulled by the pull-type central shaft handle 2-11, so that the pull-type central shaft 2-8 and the channel of the outer frame 2-1 are in the corresponding position of the supplement, and the positioning plug 2-2 is put in again. The main handle 7-3 of the manual rotating structure 7 is rotated or the motor rotating structure 8 is started to supplement the program, and the drug solution is also pumped out. Among them, the drug solution collected during the supplementing process is first discarded to the waste liquid tank 9-13 of the middle plate structure 9 according to the experimental requirements, and after the discarding is completed, the flat push plate 9-2 is immediately pushed inward to the bottom, and the flat push plate 9-2 is lifted to the specified position by the gasket 9-10. Then the drug solution in the syringe is pumped into the sample vial (at the same time, the dissolution medium is pumped into the dissolution cup), and after the solution collected in the sample vial reaches the appropriate volume, the gasket 9-10 is pulled out, the flat push plate 9-2 is moved outward, the remaining drug solution is pumped into the waste liquid tank 9-13 of the middle plate structure 9 (at the same time, the remaining dissolution medium is pumped into the dissolution cup), the sample vial is taken out from the sample vial plate 9-6, the cap is screwed on, and a new sample vial is put in. The positioning plug 2-2 is taken out, the pull-type central shaft 2-8 is pushed by the pull-type central shaft handle 2-11, so that the pull-type central shaft 2-8 and the channel of the outer frame 2-1 are in the corresponding position of sampling, and the positioning plug 2-2 is put in again. After the position is determined, the sampling operation at the next time point is prepared. The above operation is repeated for each sampling until the sampling experiment is completed.

[0108] After the experiment is completed, the pipeline and the syringe are cleaned with purified water (whether to take out the syringe for re-cleaning or replacement is determined according to the situation). The gasket 9-10 is put into the gasket drawer 9-12, and if the motor rotating structure 8 is used, the power switch is turned off and the power plug is pulled out.

[0109] When the dissolution tester semi-automatic sampler is used, if the rotary multi-channel valve array structure 3 of Example 3 is installed and used, the operation steps are as follows:

[0110] The needle filter is fixed to the lower head 3-16 of the rotary multi-channel valve rotor, and all the rotor rods 3-15 are checked to be in the corresponding positions of the rotor rod fixing grooves 3-10. After the temperature of the medium in the dissolution cup and the medium to be supplemented reaches the requirement, the medicine is administered according to the operation procedure of the dissolution tester used. 20 seconds before each sampling time, the main handle 7-3 of the manual rotating structure 7 or the sampling program of the motor rotating structure 8 is rotated to sample (the dissolution medium is also sucked into the corresponding syringe), and the sampled liquid is immediately returned to the dissolution cup to wet the pipeline. Then the main handle 7-3 of the manual rotating structure 7 or the sampling program of the motor rotating structure 8 is rotated again to sample, and the rotor rod 3-15 is immediately rotated to the corresponding position of the rotor rod fixing groove 3-10 for supplementing the liquid. The main handle 7-3 of the manual rotating structure 7 or the supplementing program of the motor rotating structure 8 is rotated to supplement the liquid (the liquid is also discharged at the same time). During the supplementing process, the liquid collected is first discarded to the waste liquid groove 9-13 of the middle plate structure 9 according to the specified volume, and after the discarding is completed, the flat plate 9-2 is immediately pushed inward to the bottom, and the flat plate 9-2 is lifted to the specified position by the gasket 9-10. Then the liquid in the syringe is injected into the sampling vial (at the same time, the dissolution medium is injected into the dissolution cup), and after the solution collected in the sampling vial reaches the appropriate volume, the gasket 9-10 is pulled out, the flat plate 9-2 is moved outward, the remaining liquid is injected into the waste liquid groove 9-13 of the middle plate structure 9 (at the same time, the remaining dissolution medium is injected into the dissolution cup), the sampling vial is taken out from the sampling vial plate 9-6, the cap is screwed, and a new sampling vial is put in. The rotor rod 3-15 is rotated to the corresponding position of the rotor rod fixing groove 3-10 for sampling. After the position is determined, the sampling operation at the next time point is prepared. The above operation is repeated for each sampling until the sampling experiment is completed.

[0111] After the experiment is completed, the pipeline and the syringe are cleaned with purified water (whether the syringe is taken out for cleaning or replaced is determined according to the situation). The gasket 9-10 is placed in the gasket drawer 9-12, and if the motor rotating structure 8 is used, the power switch is turned off and the power plug is pulled out.

[0112] Finally, it should be pointed out that the above examples are only used to illustrate the technical solutions of the present application and are not limiting. Those skilled in the art should understand that any changes, or similar substitutions or improvements that do not deviate from the corresponding concepts of the technical features of the present application are included within the protection scope of the present application. The contents not described in detail in the specification are the existing technology known to those skilled in the art.

Claims

1. A multiple passage valve manifold structure, characterized by, The utility model relates to a kind of multi-channel valve conversion block structures of plug-in type, including rotating screw fixed block structure, plug moving block structure and plug-in type multi-channel valve conversion block structure;The rotating screw fixed block structure includes rotating screw, rotating screw fixed block, chain, columnar synchronous shaft, rotating screw fixed block bearing cavity, rotating screw fixed block bottom sheet;The plug moving block structure includes plug moving block, columnar synchronous shaft sleeve, straight pipe plug, fixed bottom plate, plug moving block bottom sheet, plug moving block thread cavity, plug moving block hose;The plug-in type multi-channel valve conversion block structure includes plug-in type multi-channel valve conversion block, plug-in type multi-channel valve conversion block lower stud, plug-in type multi-channel valve conversion block hose, plug-in type upper straight channel, plug-in type lower straight channel, plug-in type upper curved channel, plug-in type lower curved channel;The rotating screw is connected rotating screw fixed block and plug moving block by rotating screw fixed block bearing cavity and plug moving block thread cavity, and is connected side handle stirring screw by chain, the chain is connected with rotating screw and side handle stirring screw respectively, side handle screw fixed block is directly fixed in upper plate body right side, side handle stirring screw is clamped in side handle screw fixed block by bearing, side handle and side handle stirring screw are integrated, for rotating side handle stirring screw, so that rotating screw fixed block can move back and forth, the plug-in type multi-channel valve conversion block is fixed in upper plate body, columnar synchronous shaft is arranged on rotating screw fixed block, columnar synchronous shaft sleeve is arranged on plug moving block, the columnar synchronous shaft is clamped into columnar synchronous shaft sleeve, rotating screw fixed block bottom sheet and plug moving block bottom sheet are embedded into fixed bottom plate defined rotating screw fixed block moving boundary, rotating screw fixed block bottom sheet moving boundary, plug moving block moving boundary, plug moving block bottom sheet moving boundary, to limit rotating screw fixed block and plug moving block back and forth and left and right moving range, plug moving block hose is arranged on the side of plug moving block close to rotating screw fixed block, straight pipe plug is arranged on the side of plug moving block away from rotating screw moving block, fixed bottom plate connects upper plate body;The plug-in type upper straight channel is located directly above plug-in type lower straight channel, plug-in type upper curved channel is located directly above plug-in type lower curved channel, plug-in type multi-channel valve conversion block lower stud is directly connected plug-in type lower curved channel lower side mouth, and needle filter is passed to inject liquid medicine into sample vial, the distance between straight pipe plug and plug moving block hose is equal, and both are channel structure formed by plug-in type upper straight channel and plug-in type lower straight channel, and the distance between channel structure formed by plug-in type upper curved channel and plug-in type lower curved channel is 2 times;The straight pipe plug is integrally pushed into the front side mouth of plug-in type upper straight channel, plug-in type lower straight channel of plug-in type multi-channel valve conversion block structure and the front side mouth of plug-in type upper curved channel, plug-in type lower curved channel respectively, the plug moving block hose is connected syringe.The insertion type multi-channel valve conversion block connects the sampling needle and the liquid supplementing needle of the dissolution tester. When the injector is connected to the upper straight channel and the lower straight channel of the insertion type, the dissolution medium is sucked through the upper straight channel and the drug solution in the dissolution cup is sucked through the lower straight channel. When the injector is connected to the upper curved channel and the lower curved channel of the insertion type, the dissolution medium is supplemented to the dissolution cup through the upper curved channel, and the extracted drug solution is injected into the sampling vial through the lower curved channel.

2. The multiple passage valve manifold arrangement of claim 1, wherein, The rotating screw fixing block structure and the plug moving block structure are solid plastic or metal cuboid structures; the rotating screw fixing block bearing cavity is connected with the rotating screw by a bearing, and the plug moving block threaded cavity is connected with the rotating screw by a thread; the diameters of the upper straight insertion channel, the lower straight insertion channel, the upper curved insertion channel and the lower curved insertion channel are approximately equal to the outer diameter of the nipple of the syringe; the number of the channel structures composed of the upper straight insertion channel and the lower straight insertion channel is equal to the number of the channel structures composed of the upper curved insertion channel and the lower curved insertion channel; the number of the straight pipe plugs is equal to the number of the plug moving block hoses, and is equal to the number of the channel structures composed of the upper straight insertion channel and the lower straight insertion channel and the number of the channel structures composed of the upper curved insertion channel and the lower curved insertion channel.

3. A multiple passage valve manifold structure, characterized by, The utility model provides a kind of multi-channel injection device, including outer frame structure and pullout type central axis structure;The outer frame structure includes outer frame, positioning plug, outer frame positioning square hole, middle square hole, outer frame channel, pullout type multi-channel valve lower stem, outer frame hose;The pullout type central axis structure includes pullout type central axis, central axis liquid supplementing positioning square hole, central axis sampling positioning square hole, pullout type central axis handle, pullout type upper straight channel, pullout type lower straight channel, pullout type upper curved channel, pullout type lower curved channel;The outer frame is fixed on upper plate body, and the middle square hole is arranged on the side of outer frame, and the outer frame positioning square hole is arranged on the top of outer frame near the one end of middle square hole, and the outer frame channel is arranged on the front and back walls of outer frame, and the outer frame channel position on the front and back walls of outer frame corresponds, and the outer frame channel on back wall is connected with outer frame hose, and pullout type multi-channel valve lower stem is arranged on the bottom of outer frame, and outer frame structure is accommodated and clamped pullout type central axis structure through middle square hole;The pullout type central axis handle is arranged on one side of pullout type central axis, and the central axis liquid supplementing positioning square hole and the central axis sampling positioning square hole are arranged on the top of pullout type central axis corresponding to the position of positioning square hole, and the positioning plug is inserted and taken out outer frame positioning square hole and central axis liquid supplementing positioning square hole / central axis sampling positioning square hole, to determine the position that the channel of pullout type central axis structure corresponds with outer frame channel, and it is connected with syringe outward through outer frame channel, and it is connected with dissolution cup and liquid supplementing cup through outer frame hose, and drug liquid is injected into sample vial through pullout type multi-channel valve lower stem;Pullout type upper straight channel, pullout type lower straight channel, pullout type upper curved channel, pullout type lower curved channel are arranged on pullout type central axis;The pullout type upper straight channel is located directly above pullout type lower straight channel, and the pullout type upper curved channel is located directly above pullout type lower curved channel, and pullout type multi-channel lower stem is directly connected with the lower side mouth of pullout type lower curved channel, and the channel structure formed by pullout type upper straight channel and pullout type lower straight channel is repeatedly arranged adjacent to the channel structure formed by pullout type upper curved channel and pullout type lower curved channel;The pullout type upper straight channel, pullout type lower straight channel, pullout type upper curved channel are communicated with outer frame channel, and the left and right distance between outer frame channel on the front and back walls of outer frame is twice the left and right distance between the channel structure formed by pullout type upper straight channel and pullout type lower straight channel and the channel structure formed by pullout type upper curved channel and pullout type lower curved channel, and syringe and dissolution cup, liquid supplementing cup are connected through outer frame channel by pullout type upper straight channel, pullout type lower straight channel, pullout type upper curved channel, pullout type lower curved channel, when syringe is connected with pullout type upper straight channel and pullout type lower straight channel, dissolution medium is sucked through pullout type upper straight channel, and drug liquid in dissolution cup is sucked through pullout type lower straight channel, when syringe is connected with pullout type upper curved channel and pullout type lower curved channel, dissolution medium is added to dissolution cup through pullout type upper curved channel, and the drug liquid taken out is injected into sample vial through pullout type multi-channel valve lower stem through pullout type lower curved channel.

4. The multiple passage valve manifold arrangement of claim 3, wherein, The diameter of the pull-up straight channel, the pull-down straight channel, the pull-up curved channel and the pull-down curved channel is similar to the outer diameter of the syringe nipple; the number of the channel structure composed of the pull-up straight channel and the pull-down straight channel is equal to the number of the channel structure composed of the pull-up curved channel and the pull-down curved channel; the two side walls of the pull-up central shaft with the pipeline opening are plated with a layer of rubber respectively; the number of the outer frame body hose is equal to the number of the channel structure composed of the pull-up straight channel and the pull-down straight channel or the number of the channel structure composed of the pull-up curved channel and the pull-down curved channel; the number of the pull-up multi-channel valve lower column head is half of the number of the outer frame body hose.

5. A multiple passage valve manifold structure, characterized by, The utility model provides a kind of multi-channel valve rotating body and rotating multi-channel valve block structure, and the rotating multi-channel valve block structure includes rotating multi-channel valve block, rotating multi-channel valve block channel, fixed plate, rotating body rod fixed block, cylindrical cavity, fixed plate hole, fixed plate screw, rotating body rod position baffle, rotating body rod fixed slot, rotating multi-channel valve block hose;The multi-channel valve rotating body includes upper cylinder, lower cylinder, rotating upper straight channel, rotating lower straight channel, rotating upper curved channel, rotating lower curved channel, rotating body rod, rotating multi-channel valve rotating body lower stem;Rotating body rod fixed slot is located on rotating body rod fixed block, and both sides stand rotating body rod position baffle that position manual rotation rotating body rod amplitude, rotating body rod fixed block connects rotating multi-channel valve block, and rotating multi-channel valve block has cylindrical cavity inside, and rotating multi-channel valve block top is provided with two fixed plates;Multi-channel valve rotating body is located in cylindrical cavity, and upper cylinder is integrally connected with lower cylinder, and rotating body rod is fixed on upper cylinder;Fixed plate screw passes through fixed plate hole and fixes fixed plate in rotating multi-channel valve block and covers multi-channel valve rotating body, and upper cylinder extends via the gap between two fixed plates, and rotating multi-channel valve block front and back wall is provided with rotating multi-channel valve channel, and rotating multi-channel valve block channel is connected with rotating multi-channel valve hose on back wall, and rotating upper straight channel, rotating lower straight channel, rotating upper curved channel and rotating lower curved channel are all provided on lower cylinder;Rotating upper straight channel is located directly above rotating lower straight channel, and rotating upper curved channel is located directly above rotating lower curved channel, and the channel structure of rotating upper straight channel and rotating lower straight channel is vertically arranged with the channel structure of rotating upper curved channel and rotating lower curved channel without intersection, and the lower side of rotating lower curved channel is connected with rotating multi-channel valve rotating body lower stem, and rotating multi-channel valve rotating body lower stem is inserted into sample vial mouth through needle filter;Rotating multi-channel valve rotating body lower stem is connected with rotating lower curved channel upward, and penetrates rotating multi-channel valve block structure bottom small hole downward, and is connected with syringe outward through rotating multi-channel valve block channel, and is connected with dissolution cup and make-up cup through rotating multi-channel valve block hose, when syringe is connected with rotating upper straight channel and rotating lower straight channel, dissolution medium is absorbed through rotating upper straight channel, and drug solution in dissolution cup is absorbed through rotating lower straight channel, after rotation, when syringe is connected with rotating upper curved channel and rotating lower curved channel, dissolution medium is added to dissolution cup through rotating upper curved channel, and drug solution is injected into sample vial through rotating lower curved channel and rotating multi-channel valve rotating body lower stem.

6. The multiple passage valve manifold arrangement of claim 5, wherein, The movable angle of the multi-channel valve rotating body is 90°; the diameters of the rotating upper straight channel, the rotating lower straight channel, the rotating upper curved channel and the rotating lower curved channel are similar to the outer diameter of the syringe nipple; the number of channel structures composed of the rotating upper straight channel and the rotating lower straight channel is equal to the number of channel structures composed of the rotating upper curved channel and the rotating lower curved channel; the lower cylindrical side of the multi-channel valve rotating body is plated with a layer of rubber; the number of rotating multi-channel valve block channels on the front wall of the rotating multi-channel valve block is the sum of the number of rotating multi-channel valve block hoses connected to the rear wall and the number of rotating multi-channel valve rotating body lower column heads.

7. A dissolution tester semi-automatic sampler, comprising a multi-channel valve array structure, a syringe cylinder fixing block structure, a syringe piston fixing block structure, an upper plate body structure, a rotating structure, a middle plate body structure, and a lower plate body structure; the multi-channel valve array structure is one of an insertion type multi-channel valve array structure, a pull-out type multi-channel valve array structure, and a rotating type multi-channel valve array structure; the insertion type multi-channel valve array structure is the multi-channel valve array structure of claim 1 or 2; the pull-out type multi-channel valve array structure is the multi-channel valve array structure of claim 3 or 4; the rotating type multi-channel valve array structure is the multi-channel valve array structure of claim 5 or 6; the upper plate body structure and the lower plate body structure are connected through the middle plate body structure, the multi-channel valve array structure is directly fixed on the upper plate body and connected with the cylinder fixing block fixed on the upper plate body, and the rotating structure drives the syringe piston fixing block structure to move forward and backward; the rotating structure includes a manual rotating structure and a motor rotating structure.

8. The dissolution apparatus semi-automatic sampler according to claim 7, wherein, The injector cylinder fixing block structure comprises an injector cylinder fixing block, a cylinder fixing block long column fixing position, a cylinder fixing block long screw hole, a cylinder fixing block short screw hole, a cylinder fixing block injector piston handle hole, a cylinder fixing block injector cylinder handle clamping point, a cylinder fixing block short screw, a cylinder fixing block long column, a cylinder fixing block long column long screw hole, a cylinder fixing block long column short screw hole, a cylinder fixing block long column handle, an injector cylinder hole, a cylinder clamping block plate fixing position, an injector cylinder clamping block plate, an injector cylinder clamping block column, a cylinder clamping block long screw hole and a cylinder fixing block long screw; the injector cylinder penetrates the injector cylinder fixing block through the injector cylinder hole, the injector cylinder handle is clamped into the cylinder fixing block injector cylinder handle clamping point, the injector piston enters the cylinder fixing block injector cylinder handle clamping point through the cylinder fixing block long column fixing position and penetrates the injector cylinder fixing block through the cylinder fixing block injector piston handle hole; the cylinder fixing block long column is inserted into the cylinder fixing block long column fixing position through the cylinder fixing block long column handle, the cylinder fixing block short screw is screwed into the cylinder fixing block long column short screw hole and the cylinder fixing block short screw hole in sequence to fix the cylinder fixing block long column, the injector cylinder clamping block plate is integrally connected with the injector cylinder clamping block column, the other side of the injector cylinder fixing block clamps the injector cylinder clamping block plate with the injector cylinder clamping block column into the cylinder clamping block plate fixing position, the cylinder fixing block long screw is screwed into the cylinder fixing block long column long screw hole, the cylinder clamping block long screw hole and the cylinder fixing block long screw hole in sequence to integrally fix the cylinder fixing block long column and the injector cylinder clamping block, thereby fixing the position of the injector, the position of the injector cylinder clamping block column is between the upper and lower injectors, and the injector cannot shake up and down during use; the injector piston fixing block structure comprises an injector piston fixing block, a piston fixing block long column fixing position, a piston fixing block bottom sliding body, a piston fixing block injector piston handle hole, a piston fixing block injector piston handle clamping point, a piston fixing block threaded cavity, a piston fixing block long column, a piston fixing block long column threaded cavity, a piston fixing block long column screw hole, a piston fixing block long column handle, a piston fixing block screw, and a piston fixing block screw hole; the injector piston penetrating the injector cylinder fixing block enters the piston fixing block injector piston handle clamping point through the piston fixing block long column fixing position, the piston column body penetrates the piston fixing block injector piston handle hole, and the injector piston handle is clamped into the piston fixing block injector piston handle clamping point; the piston fixing block long column is inserted into the piston fixing block long column fixing position through the piston fixing block long column handle, and the piston fixing block screw is screwed into the piston fixing block long column screw hole and the piston fixing block screw hole in sequence to fix the piston fixing block long column; the main handle stirring screw of the manual rotation structure or the motor stirring screw of the motor rotation structure is screwed into the piston fixing block threaded cavity and the piston fixing block long column threaded cavity in sequence to integrally fix the injector piston fixing block and the piston fixing block long column, and the injector piston fixing block structure can move forward and backward; the piston fixing block bottom sliding body is clamped in the piston fixing block bottom sliding body clamping position of the upper plate body structure.The upper plate body structure includes an upper plate body, a multi-channel valve array structure screw hole, a side handle screw fixing block, a side handle stirring screw, a side handle, a cylinder fixing block screw hole, and a piston fixing block bottom sliding body clamping position; the piston fixing block bottom sliding body clamping position stabilizes the piston fixing block bottom sliding body, the cylinder fixing block screw hole fixes the position of the syringe cylinder fixing block structure on the upper plate body, and the multi-channel valve array structure screw hole fixes the position of the plug-in multi-channel valve array structure, the pull-out multi-channel valve array structure or the rotary multi-channel valve array structure on the upper plate body; the side handle screw fixing block is fixed on the right side of the upper plate body, the side handle stirring screw is connected with the bearing in the side handle screw fixing block, the side handle is integrally connected with the side handle stirring screw, and is connected with the chain of the plug-in multi-channel valve array structure; the manual rotating structure includes a main handle screw fixing block, a main handle stirring screw, a main handle, a positioning column and a positioning hole; the main handle screw fixing block is fixed on the upper plate body, the main handle stirring screw is connected with the main handle screw fixing block and the syringe piston fixing block, the main handle and the main handle stirring screw are integrally connected, the positioning column passes through the round hole on the main handle and can be horizontally clamped into the positioning hole on the main handle screw fixing block to fix the rotating degree of the main handle; the motor rotating structure includes a stepping motor, a controller, a motor stirring screw, a power supply, a motor driver, a timer and a PCB circuit board; the stepping motor, the controller, the power supply, the motor driver and the timer are fixed on the upper plate body, the stepping motor is connected with the motor stirring screw, and the motor stirring screw is connected with the syringe piston fixing block structure; the middle plate body structure includes a middle plate body, a flat push plate, a flat push plate handle, a sample vial plate clamping position, a side plate moving track, a sample vial plate, a sample vial hole, a left plate body, a right plate body, a gasket, a gasket handle, a gasket drawer, a waste liquid tank, a waste liquid inlet hole and a waste liquid tank valve; the left plate body and the right plate body are connected on the two sides of the middle plate body, each of the left plate body and the right plate body has a side plate moving track, which is used for providing a fixed track of the flat push plate and determining the specified position of the flat push plate during operation, the sample vial plate clamping position on the flat push plate is used for placing the sample vial plate, and the sample vial hole on the sample vial plate is used for placing the sample vial for high performance liquid chromatography; the flat push plate handle is connected with the flat push plate, the gasket is used for fixing the height of the flat push plate during use, the gasket handle is used for sending and pulling out the gasket, and the gasket drawer is used for temporarily storing the gasket; the waste liquid tank is fixed on the lower side of the middle plate body, the waste liquid inlet hole is used for receiving the primary filtrate to be discarded, and the waste liquid tank valve is used for saving and discharging the waste liquid; the lower plate body structure includes a lower plate body, a table surface fixing hole, a side fixing block connecting hole, a table surface fixing screw, a front fixing block, a front fixing hole, a side fixing block, a side fixing hole and a fixing block screw; the lower plate body has 2-6 table surface fixing holes, the table surface fixing screw passes through the table surface fixing hole and enters the experimental table surface, each side of the lower plate body has 2-4 side fixing block connecting holes, and the fixing block screw passes through the side fixing block connecting hole and the side fixing hole of the side fixing block and enters the lower plate body.The lower plate body has 4-10 front fixing block connecting holes on the inner side, and the fixing block screw passes through the front fixing hole of the front fixing block and the front fixing block connecting hole into the lower plate body.

9. The dissolution apparatus semi-automatic sampler of claim 8, wherein, The number of syringes that can be fixed on the syringe cylinder fixing block structure in two rows is 4-60; the size of the syringes is standard 2mL, 3mL, 5mL, 10mL, 20mL, or 50mL syringes; the opposite side of the cylinder fixing block long column handle is a semicircular spherical protrusion, which is consistent in shape with the semicircular spherical groove at the corresponding position of the cylinder fixing block long column fixed position, and the opposite side of the piston fixing block long column handle is a semicircular spherical protrusion, which is consistent in shape with the semicircular spherical groove at the corresponding position of the piston fixing block long column fixed position; the number of sample vial holes is consistent with the number of syringes that can be installed at most.

10. A method of using a dissolution apparatus semi-automatic sampler, characterized in that The dissolution tester semi-automatic sampler of any one of claims 8-9, the method comprising the steps of: Before the operation of the three multi-channel valve bank structure corresponding to the dissolution tester semi-automatic sampler begins, the lower plate body structure is stably installed on the experimental bench by being directly fixed to the bench top or through a fixing block; the syringe is inserted into the syringe cylinder hole, so that the syringe cylinder handle is clamped at the cylinder fixing block syringe cylinder handle clamping point, and the cylinder fixing block long column and the syringe cylinder clamping block plate are respectively installed and tightened to fix the position of the syringe; the syringe piston inserted from the cylinder fixing block syringe piston handle hole is inserted into the piston fixing block syringe piston handle clamping point, and the piston fixing block long column is installed and tightened to fix the position of the syringe piston; the pipeline and plug of the plug-in multi-channel valve bank structure and the syringe cylinder fixing block structure are connected, and a disposable needle filter is installed; the flat push plate of the middle plate body structure is kept in a position not covering the waste liquid inlet hole, the waste liquid tank valve is closed, the sample vial is placed into the sample vial hole, and the sample vial plate is placed into the sample vial plate clamping position; the position of the main handle of the manual rotation structure and the positioning column is adjusted or the circuit of the motor rotation structure is checked, the power supply is turned on, and the switch is opened; at the same time, sufficient medium at a proper temperature and a correctly placed liquid supplement pipeline are ensured; The method further includes any one of the following three steps: M1: the needle filter is fixed to the lower column head of the plug-in multi-channel valve conversion block, and the straight pipe plug of the plug moving block is checked to be in the sampling corresponding channel of the plug-in multi-channel valve conversion block; after the temperature of the medium in the dissolution cup and the medium to be supplemented reaches the requirement, the drug is administered according to the operation program of the dissolution tester; 20 seconds before each sampling time, the main handle of the manual rotation structure is rotated or the sampling program of the motor rotation structure is started to sample, and the sampled liquid is immediately returned to the dissolution cup to wet the pipeline; then the main handle of the manual rotation structure is rotated or the sampling program of the motor rotation structure is started again to sample, the straight pipe plug of the plug moving block is immediately transferred to the liquid supplement corresponding channel of the plug-in multi-channel valve conversion block, the main handle of the manual rotation structure is rotated or the liquid supplement program of the motor rotation structure is started to supplement liquid; wherein the liquid collected during the liquid supplement process is first discarded to the waste liquid tank of the middle plate body structure according to the specified volume, after the discarding is completed, the flat push plate is immediately pushed inward to the head, and the flat push plate is raised to the specified position by using a gasket; then the liquid in the syringe is injected into the sample vial, after the solution collected by the sample vial reaches a proper volume, the gasket is pulled out, the flat push plate is moved outward, the remaining liquid is injected into the waste liquid tank of the middle plate body structure, the sample vial is taken out from the sample vial plate, the cap is screwed on, and a new sample vial is placed; the straight pipe plug of the plug moving block is placed into the sampling corresponding channel of the plug-in multi-channel valve conversion block, and after the position is determined, the sampling operation at the next time point is prepared; the above operation is repeated for each sampling until the sampling experiment is completed; After the experiment is completed, the pipeline and the syringe are cleaned with purified water; the gasket is placed into the gasket drawer, and if the motor rotation structure is used, the power supply switch is turned off and the power plug is pulled out. M2: Fix the needle filter under the lower column head of the pull-type multi-channel valve, check the position of the pull-type central shaft and the channel of the outer frame body with the positioning plug; after the temperature of the medium in the dissolution cup and the medium to be supplemented reaches the requirement, perform the drug injection according to the operation procedure of the dissolution tester; 20 seconds before each sampling time, rotate the main handle of the manual rotating structure or start the motor rotating structure to sample, immediately return the sampled liquid to the dissolution cup to wet the pipeline; then rotate the main handle of the manual rotating structure or start the motor rotating structure to sample again, remove the positioning plug, pull the pull-type central shaft through the pull-type central shaft handle, so that the pull-type central shaft and the channel of the outer frame body are in the corresponding position of the liquid supplementing, and then put the positioning plug again; rotate the main handle of the manual rotating structure or start the motor rotating structure to supplement the liquid; wherein, the collected liquid during the liquid supplementing process is first discarded to the waste liquid tank of the middle plate structure according to the experimental requirement, after the discarding is completed, immediately push the flat plate inward to the bottom, and use the gasket to lift the flat plate to the specified position; then inject the liquid in the syringe into the sampling vial, after the collected solution in the sampling vial reaches the appropriate volume, remove the gasket, move the flat plate outward, inject the remaining liquid into the waste liquid tank of the middle plate structure, take out the sampling vial from the sampling vial plate, screw on the cap, and put in a new sampling vial; remove the positioning plug, push the pull-type central shaft through the pull-type central shaft handle, so that the pull-type central shaft and the channel of the outer frame body are in the corresponding position of the sampling, and then put the positioning plug again; after the position determination is completed, prepare for the sampling operation at the next time point; repeat the above operation for each sampling until the sampling experiment is completed; After the experiment is completed, clean the pipeline and the syringe with purified water; put the gasket into the gasket drawer, if the motor rotating structure is used, turn off the power switch and pull out the power plug; M3: Fix the needle filter under the lower column head of the rotary multi-channel valve rotary body, check if all the rotary body rods are in the corresponding position of the rotary body rod fixing groove; after the temperature of the medium in the dissolution cup and the medium to be supplemented reaches the requirement, carry out the drug delivery according to the operation procedure of the dissolution tester; 20 seconds before each sampling time, rotate the main handle of the manual rotating structure or start the motor rotating structure sampling program to carry out sampling, and immediately return the sampled liquid to the dissolution cup to wet the pipeline; then rotate the main handle of the manual rotating structure or start the motor rotating structure sampling program to carry out sampling again, immediately move the rotary body rod to the corresponding position of the rotary body rod fixing groove for liquid supplementing; rotate the main handle of the manual rotating structure or start the motor rotating structure liquid supplementing program to carry out liquid supplementing; wherein, the liquid collected during the liquid supplementing process is first discarded to the waste liquid groove of the middle plate body structure according to the specified volume, after the discarding is completed, immediately push the flat push plate to the bottom, and use the gasket to lift the flat push plate to the specified position; then inject the liquid in the syringe into the sampling vial, after the solution collected in the sampling vial reaches the appropriate volume, pull out the gasket, move the flat push plate outward, inject the remaining liquid into the waste liquid groove of the middle plate body structure, take out the sampling vial from the sampling vial plate, screw on the cap, and put in a new sampling vial; move the rotary body rod to the corresponding position of the rotary body rod fixing groove for sampling; after the position is determined, prepare for the sampling operation at the next time point; repeat the above operation for each sampling until the sampling experiment is completed; After the experiment is completed, clean the pipeline and syringe with purified water; put the gasket into the gasket drawer, and if the motor rotating structure is used, turn off the power switch and pull out the power plug.

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