Incubation device, chemiluminescence immunoassay analyzer and self-checking method thereof

Abstract

The application provides an incubation device, a chemiluminescence immunoassay analyzer and a self-checking method thereof. The incubation device comprises: an incubation main body; an incubation assembly, which comprises: a shell, the shell being arranged on the incubation main body; an incubation disc, the incubation disc being arranged inside the shell and rotating around the shaft center of the shell, a plurality of hole positions for bearing reaction tubes being arranged on the incubation disc, and the hole positions being arranged in multiple annular rings on the incubation disc; a first sensor, which is arranged on the shell and is used for detecting whether the reaction tubes are placed on the incubation disc; a heating assembly, which is arranged inside the shell and is used for keeping the temperature inside the incubation assembly stable; a processing ring assembly, which is arranged outside the incubation assembly and rotates around the incubation assembly, and the processing ring assembly comprises a plurality of reaction tube placing positions; and a second sensor, which is arranged on the incubation main body and is used for detecting whether the reaction tubes are placed on the processing ring assembly. The first sensor and the second sensor are arranged in the incubation device, so that the detection time can be shortened and the work efficiency can be improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medical detection equipment, in particular to an incubation device, a chemiluminescence immunoassay analyzer and a self-checking method thereof. BACKGROUND

[0002] The chemiluminescence immunoassay analyzer is a medical detection instrument for immune analysis of human body by detecting patient serum, mainly including a sample library, a tube library unit, a cleaning unit, a detection unit and an incubation device, etc. The incubation device is used to provide a constant temperature environment for the reaction of samples and reagents in the reaction tube.

[0003] However, the structure design of the traditional incubation device has defects, resulting in poor heat preservation performance and affecting the detection results of the chemiluminescence immunoassay analyzer. When the incubation device is abnormally powered off, the self-checking program will be automatically started when the machine is turned on to detect whether there are still reaction tubes in the incubation device. The self-checking program of the current incubation device is complex, and there are problems such as long self-checking time and large self-checking error. SUMMARY

[0004] In view of the technical problems existing in the prior art, the present application provides an incubation device, which comprises: an incubation main body; an incubation assembly, comprising: an outer shell arranged on the incubation main body; an incubation disc arranged inside the outer shell and rotating around the axis of the outer shell, a plurality of hole positions for carrying reaction tubes are arranged on the incubation disc, and the hole positions are arranged in multiple annular rings on the incubation disc; a first sensor arranged on the outer shell and used for detecting whether the reaction tubes are placed on the incubation disc; a heating assembly arranged inside the outer shell, the heating assembly being used for keeping the temperature inside the incubation assembly stable; a processing ring assembly arranged outside the incubation assembly and rotating around the incubation assembly, the processing ring assembly comprising a plurality of reaction tube placing positions; a second sensor arranged on the incubation main body and used for detecting whether the reaction tubes are placed on the processing ring assembly; and a control unit, in response to the detection of the reaction tubes by the first sensor and / or the second sensor, the control unit controls one or more grippers to move the reaction tubes into the processing ring assembly and / or a waste channel. By installing the first sensor and the second sensor in the incubation device, it can be detected whether there are reaction tubes on the incubation disc and the processing ring assembly, respectively, to prevent the problem of residual reaction tubes caused by abnormal shutdown and improve the working stability of the incubation device.

[0005] The incubation device as described above, the first sensor is arranged in multiple annular rings to simultaneously detect the placement state of the reaction tubes in multiple hole positions.

[0006] The incubation device as described above, the number of reaction tube placing positions is 6-15.

[0007] The incubation device as described above, the incubation assembly further comprises: an upper cover, which is covered on the shell, and one or more oval holes for the reaction tube to pass through when being put in or taken out are formed on the upper cover; and heat preservation cotton, which is covered on the inner wall of the shell; wherein the shell comprises an inner layer, when the upper cover is arranged on the shell, the shell, the inner layer, the upper cover and the heat preservation cotton form a heat preservation space.

[0008] The incubation device as described above, the heating assembly comprises: a heating module; a heat conduction module, which is arranged on the heating module; a temperature sensor, which is electrically connected with the control unit to transmit a temperature detection signal; and a temperature control switch, which is electrically connected with the control unit to receive a switch instruction, and controls the temperature control switch to turn on or off the heating module according to the temperature detection signal; wherein the heat conduction module is a ring-shaped U-shaped groove, which is provided with a groove for the detection signal near the first sensor; the first sensor is a photoelectric sensor, which comprises a corresponding arranged emitting end and receiving end, and the groove is correspondingly arranged with the emitting end.

[0009] The incubation device as described above, further comprises a mixing device, which is arranged on the incubation main body and below the processing ring assembly, and is used to carry the reaction tube to rotate to mix the liquid in the reaction tube; the mixing device comprises: a mixing seat; a mixing motor, which is arranged on the mixing seat and provides power for the rotation of the reaction tube; a mixing block, which is arranged on the rotor of the mixing motor, and the top surface of the mixing block is provided with a blind hole for accommodating the reaction tube; and a lead screw motor, which is movably connected with the mixing seat, and is used to drive the mixing block to move in the vertical direction.

[0010] The incubation device as described above, the blind hole is arranged at an eccentric position of the mixing block, and the opening of the blind hole is trumpet-shaped.

[0011] According to another aspect of the present application, a chemiluminescence immunoassay instrument is provided, which comprises a tube library unit, a cleaning unit and a detection unit, and further comprises the incubation device as described above, which provides a constant temperature environment for the reaction of the sample and the reagent in the reaction tube.

[0012] The chemiluminescence immunoassay instrument as described above, the incubation main body comprises a first reset sensor, the processing ring assembly comprises a first trigger plate, and in response to the end of the detection program of the chemiluminescence immunoassay instrument, when the processing ring assembly rotates to the position where the first reset sensor detects the first trigger plate, the control unit controls the processing ring assembly to stop rotating.

[0013] The chemiluminescence immunoassay analyzer as described above, wherein the mixing device further comprises a second reset sensor and a second trigger plate, the second reset sensor is arranged on the mixing seat, and the second trigger plate is arranged on the mixing block; after the chemiluminescence immunoassay analyzer detection program ends, the mixing block stops rotating when the second reset sensor detects the position of the second trigger plate.

[0014] According to another aspect of the present application, a method for self-checking of a chemiluminescence immunoassay analyzer is provided, which utilizes the chemiluminescence immunoassay analyzer as described above to perform self-checking work, and the working steps include: controlling the incubation disc to rotate and utilizing the first sensor to detect whether the reaction tube is on the incubation disc; in response to the first sensor detecting the reaction tube, utilizing the first gripper to move the reaction tube from the incubation disc to the processing ring assembly; controlling the processing ring assembly to rotate and utilizing the second sensor to detect whether the reaction tube is on the processing ring assembly; and in response to the second sensor detecting the reaction tube, utilizing the second gripper to move the reaction tube from the processing ring assembly to the waste channel.

[0015] The method as described above, before the step of controlling the incubation disc to rotate and utilizing the first sensor to detect whether the reaction tube is on the incubation disc, comprises: controlling the processing ring assembly to rotate and utilizing the second sensor to detect whether the reaction tube is on the processing ring assembly; and in response to the second sensor detecting the reaction tube, utilizing the second gripper to move the reaction tube from the processing ring assembly to the waste channel.

[0016] The present application can detect whether the reaction tube is on the incubation disc and the processing ring assembly respectively by installing the first sensor and the second sensor in the incubation device, and can shorten the detection time by utilizing the rotation function of the incubation disc and the processing ring assembly. The chemiluminescence immunoassay analyzer of the present application can provide a constant incubation environment for the reaction tube and improve the detection efficiency of the reaction tube. BRIEF DESCRIPTION OF DRAWINGS

[0017] Hereinafter, the preferred embodiments of the present application will be further described in detail with reference to the accompanying drawings, in which:

[0018] Figure 1A is a structure diagram of an incubation device according to an embodiment of the present application;

[0019] Figure 1B is an exploded view of an incubation device according to an embodiment of the present application;

[0020] Figure 2 is a structure diagram of an incubation assembly according to an embodiment of the present application;

[0021] Figure 3 is a schematic view of an incubation disc structure according to an embodiment of the present application;

[0022] Figure 4 is a schematic view of a heating assembly structure according to an embodiment of the present application;

[0023] Figure 5 is a sectional view of an incubation device according to an embodiment of the present application;

[0024] Figure 6 is a schematic view of a treatment ring assembly structure according to an embodiment of the present application;

[0025] Figure 7 is a schematic view of an incubation body structure according to an embodiment of the present application;

[0026] Figure 8 is a schematic view of a mixing device structure according to an embodiment of the present application;

[0027] Figure 9 is a schematic view of a mixing device structure according to another embodiment of the present application;

[0028] Figure 10 is a schematic view of a chemiluminescence immunoassay analyzer according to an embodiment of the present application; and

[0029] Figure 11 is a method for self-checking of a chemiluminescence immunoassay analyzer according to an embodiment of the present application. DETAILED DESCRIPTION

[0030] In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be described clearly and completely below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, but not all of the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the scope of protection of the present application.

[0031] In the following detailed description, reference can be made to the various drawings that form a part of the present disclosure and are used to illustrate certain embodiments of the present application. In the drawings, like numerals describe substantially similar components throughout the several views. Various specific embodiments of the present application are described in sufficient detail below to enable one of ordinary skill in the art and knowledge to practice the technical solutions of the present application. It should be understood that other embodiments or structural, logical or electrical changes can also be made to the embodiments of the present application.

[0032] Figure 1A is a schematic view of an incubation device structure according to an embodiment of the present application. Figure 1Bis an incubation device according to an embodiment of the present application. As shown in Figure 1A and Figure 1B The incubation device 100 includes an incubation body 110, an incubation assembly 120, a processing ring assembly 130, and a control unit (not shown). The incubation assembly 120 and the processing ring assembly 130 are disposed on the incubation body 110, which is used to support the incubation assembly 120 and the processing ring assembly 130. The incubation assembly 120 forms a constant temperature holding space inside, and the processing ring assembly 130 is disposed on the incubation body 110 and rotates around the incubation body 110 to transport reaction tubes in different workflows. The temperature inside the incubation assembly 120 can be 37°C with an error of ±0.3-0.5°C.

[0033] The control unit is electrically connected to the electrical components of the incubation assembly 120 and the processing ring assembly 130 and a plurality of grippers, respectively, to schedule and move the reaction tubes to designated positions from the constant temperature holding space in the incubation assembly 120. The control unit can include one or more central processing units (CPUs), graphics processing units (GPUs), application-specific integrated circuits (ASICs), field-programmable gate arrays (FPGAs), or combinations thereof. The control unit can execute software or computer-readable instructions stored in a memory to perform the methods or operations described herein. The control unit can be implemented in several different ways. For example, the control unit can include one or more embedded processors, processor cores, microprocessors, logic circuitry, hardware finite state machines (FSMs), digital signal processors (DSPs), or combinations thereof.

[0034] Figure 2 is a structure diagram of an incubation assembly according to an embodiment of the present application. Figure 3 is a structure diagram of an incubation disc according to an embodiment of the present application. As shown in Figure 2 The incubation assembly 120 includes an upper cover 121, an outer shell 122, heat insulation cotton 123, and a heating assembly 124. The upper cover 121 is disposed on the outer shell 122, and one or more oval holes 1211 for the reaction tubes to pass through when being inserted or removed are formed in the upper cover 121. The outer shell 122 is an open cylinder including a bottom and an outer wall, and a through hole for accommodating a bearing is formed in the center of the bottom of the outer shell 122. The heat insulation cotton 123 is disposed on the inner wall of the outer shell 122 to play a heat insulation role. The outer shell 122 further includes an inner layer 125, which is annular and protrudes from the bottom of the outer shell 122. The inner layer 125 is concentrically disposed with the outer shell 122, and the height of the inner layer 125 is slightly less than the height of the outer shell 122, so that the upper cover 121 can be tightly disposed on the outer shell 122.

[0035] In one embodiment, the upper cover 121 and the outer shell 122 are made of plastic material, thus having good heat preservation effect. When the upper cover 121 is arranged on the outer shell 122, the outer shell 122, the inner layer 125, the upper cover 121 and the heat preservation cotton 123 surround to form a heat preservation space, providing a heat preservation environment for the reaction tube and saving electric energy.

[0036] As shown in Figure 3 and in combination Figure 1B shown, the incubation assembly 120 further comprises an incubation disc 127, which is arranged inside the outer shell 122 and rotates around the axis of the outer shell 122, and the incubation disc 127 is provided with a plurality of hole positions 1271 for carrying the reaction tube. The hole positions 1271 are arranged in multiple annular circles on the incubation disc 127. In the embodiment shown in Figure 3 , the plurality of hole positions 1271 form three concentric circles, and the three hole positions 1271 on the connecting line from the center to the outermost circle form a group, a total of 48 groups, and a total of 144 hole positions 1271. When one reaction tube is placed on the hole position 1271 every 20 seconds, it takes 48 minutes to fill up. Generally, the sample and reagent in the test tube can complete the reaction after incubation in the incubation disc for 15 minutes, therefore, the 144 hole positions 1271 can fully meet the incubation time of the reaction tube and ensure the accuracy of the detection. In actual application, the number of hole positions and the corresponding incubation time can also be reasonably adjusted according to needs.

[0037] The incubation disc 127 further comprises a support shaft 1272 and a cover plate 1273, and the bottom center of the outer shell 122 is provided with a through hole for installing a bearing, and the support shaft 1272 can be installed on the bearing. Therefore, the incubation disc 127 can carry the reaction tube to rotate around the axis of the outer shell. The cover plate 1273 is arranged at the center of the incubation disc 127 and is used to close the opening of the support shaft 1272, which can reduce the overall weight of the incubation disc and beautify the appearance.

[0038] Figure 4 is a schematic view of the heating assembly structure according to one embodiment of the present application. As shown in Figure 4 and in combination Figure 2As shown, the heating assembly 124 is disposed inside the housing 122, and is used to maintain a stable internal temperature of the heating assembly 120. The heating assembly 124 includes a heating element 1241, a heat-conducting component 1242, a temperature sensor 1243, and a temperature control switch 1244. The heating element 1241 is annular and disposed at the bottom of the housing 122, used to transfer heat to the heat-conducting component 1242. The heat-conducting component 1242 is an annular U-shaped groove disposed on the heating element 1241. The heating element 1241 can be made of aluminum, which has good thermal conductivity and can maintain a stable internal temperature for a long time. The temperature sensor 1243 is disposed on the heat-conducting component 1242, used to detect the temperature of the heat-conducting component 1242 and transmit the data to the control unit electrically connected to it. The temperature control switch 1244 is electrically connected to the control unit to receive switching commands, controlling the temperature control switch 1244 to turn the heating element 1241 on or off according to the temperature detection signal. The temperature control switch 1244 can effectively protect the safe operation of the equipment and avoid the risk of uncontrollable temperature due to the failure of the temperature sensor 1243.

[0039] Figure 5 This is a cross-sectional view of an incubation device according to an embodiment of this application. Figure 4 and Figure 5 As shown, the incubation assembly 120 also includes a first sensor 126, disposed on the outer casing 122, for detecting whether a reaction tube is placed on the incubation tray 127. Specifically, the first sensor 126 is installed within a multi-ringed structure, with a through hole 1251 for signal detection at a corresponding position on the inner layer 125, and a groove 1245 provided at a corresponding position on the heat-conducting assembly 1242. Figure 5 In the illustrated embodiment, the first sensor 126 is a photoelectric sensor, including a transmitter and a receiver, with the groove 1245 corresponding to the transmitter. Combined with... Figure 3 As shown, the first sensor 126 can simultaneously detect whether a reaction tube is placed in three holes 1271 at the same radial position on the incubation plate 127, which shortens the detection time and improves the detection efficiency.

[0040] Figure 6 This is a schematic diagram of a processing ring assembly structure according to an embodiment of this application. Figure 6 As shown, the processing ring assembly 130 includes a support ring 131, a bearing 132, a sleeve 133, and a pulley 134. The support ring 131 has multiple reaction tube placement positions 136, enabling the reaction tubes to be moved to designated positions. Among these, in... Figure 6 In the illustrated embodiment, the number of reaction tube placement positions 136 is 6-15. The support ring 131 has a through hole for accommodating the bearing 132, which is located at one end of the sleeve 133, and the pulley 134 is located at the other end of the sleeve 133. The pulley 134 is connected to a power unit, and... Figure 1BAs shown, when the processing ring assembly 130 is disposed on the incubation body 110, the processing ring assembly 130 can rotate around the axis of the incubation body 110. The support ring 131 can accommodate the incubation assembly 120, and the support ring 131 can rotate relative to the incubation assembly 120.

[0041] Figure 7 This is a schematic diagram of the incubation main structure according to an embodiment of this application. Figure 7 As shown, the incubation body 110 includes a fixed base 111, a support shaft 112, a mounting plate 113, a processing ring assembly power unit 114, an incubation assembly power unit 115, and a transition plate 116. The fixed base 111 is fixed to the contact surface to support the incubation device and maintain its structural stability. The support shaft 112 is mounted on the fixed base 111 and supports the mounting plate 113, serving as a transition device. The processing ring assembly power unit 114 is mounted on the mounting plate 113 and is movably connected to a pulley 134 via a belt, providing power for the rotation of the support ring 131. The incubation assembly power unit 115 is movably connected to the incubation disc 127 to drive its rotation. The transition plate 116 is mounted on the mounting plate 113 for fixing and transferring the incubation electrical components and circuit boards.

[0042] In one embodiment, the incubation body 110 further includes a second sensor 117, which is mounted on the mounting plate 113 using a bracket 118. When the processing ring assembly 130 is mounted on the incubation body 110, the second sensor 117 can detect whether a reaction tube is placed in one of the multiple reaction tube placement positions 136 during the rotation of the processing ring assembly 130. In response to the second sensor 117 detecting a reaction tube, the control unit controls one or more grippers to move the reaction tube into the waste channel. By utilizing the structure of multiple rotating processing ring assemblies, only one second sensor is needed to detect multiple reaction tube placement positions 136, reducing costs. Similarly, in Figure 7 In the illustrated embodiment, the second sensor 117 also employs a photoelectric sensor. Of course, in practical applications, the aforementioned first sensor 126 and second sensor 117 can also be fiber optic sensors, etc., achieving the same detection effect.

[0043] like Figure 6 and Figure 7As shown, the incubation main body 110 further comprises a first reset sensor 119, and the processing ring assembly 130 comprises a first trigger plate 135. The first reset sensor 119 is mounted on the mounting plate 113, and the first trigger plate 135 is mounted on the belt pulley 134 and can rotate with the belt pulley 134. When the processing ring assembly 130 is arranged on the incubation main body 110, the first trigger plate 135 rotates to the detection range of the first reset sensor 119, which is considered that the processing ring assembly 130 rotates to zero position. The zero position can be the position where the processing ring assembly 130 starts to work, at which time the plurality of reaction tube placing positions 136 on the supporting ring 131 rotate to the designated position, so as to ensure that the next work can be normally carried out.

[0044] Figure 8 It is a schematic view of the mixing device structure according to an embodiment of the present application. As shown in Figure 1A and Figure 8 As shown, the mixing device 140 is arranged on the incubation main body 110 and below the processing ring assembly 130, and the mixing device is used to carry the reaction tube to rotate to mix the liquid in the reaction tube. The mixing device 140 comprises a mixing seat 141, a lead screw motor 142, a mixing motor 143 and a mixing block 144. The lead screw motor 142 is fixed on the mixing seat 141, and the mixing motor 143 is arranged on the mixing seat 141. The lead screw motor 142 is used to drive the mixing motor 143 to move up and down along the slide rail 145. The mixing block 144 is arranged on the rotor of the mixing motor 143, and the mixing motor 143 can drive the mixing block 144 to rotate. A blind hole 146 is formed on the top surface of the mixing block 144, which is used to accommodate the reaction tube. The mixing device 140 can rotate the reaction tube, which is conducive to the mixing of the sample and the reagent in the reaction tube.

[0045] In an embodiment, the blind hole 146 is formed at an eccentric position on the top surface of the mixing block 144, and the opening of the blind hole is in a trumpet shape. The eccentric structure can accelerate the diffusion of the internal mixing substances, improve the mixing effect and the mixing speed, and quickly mix the reaction tube and enter the next process. Designing the blind hole in a trumpet shape is conducive to smoothly accommodating the reaction tube in the blind hole 146, and improves the working stability of the mixing device 140.

[0046] The mixing device 140 further comprises a zero position sensor 147 arranged on the mixing seat 141, which is used to monitor whether the lead screw motor 142 returns to the initial position. When the mixing device 140 completes the work, the lead screw motor 142 drives the mixing block 144 to descend, and when the lead screw motor 142 descends to the zero position, the reaction tube on the processing ring assembly 130 leaves the blind hole 146 and can rotate to the next position. In Figure 8 In the embodiment shown, the zero position sensor 147 is an optical sensor, and other sensors such as optical fiber sensor can also be used, which can also achieve the corresponding detection effect.

[0047] Figure 9is a schematic diagram of a mixing device structure according to another embodiment of the present application. As shown in Figure 9 The mixing device 150 includes a mixing seat 151, a mixing motor 152, a mixing block 153, a second reset sensor 154, and a second trigger plate 155. The mixing seat 151, the mixing motor 152, and the mixing block 153 have the same structure and function as described above, and will not be described again here. The second reset sensor 154 is arranged on the mixing seat 151, and the second trigger plate 155 is arranged on the mixing block 153. In response to the detection program of the chemiluminescence immunoassay analyzer ending, the mixing block 153 rotates to the position where the second reset sensor 154 detects the second trigger plate 155, and the mixing block 152 stops rotating. Because the blind hole on the mixing block 152 is arranged eccentrically, when the blind hole on the mixing block 152 is not on the same vertical line as the reaction tube placement position 136 above, the reaction tube placed in the blind hole is tilted, and the gripper may fail to grasp. Therefore, detecting the second trigger plate 155 by the second reset sensor 154 can ensure that the blind hole on the mixing block 152 is on the same vertical line as the reaction tube placement position 136 above. Generally, the first reset sensor 119 and the second reset sensor 154 described above can be photoelectric sensors, or sensors for detecting position including fiber optic sensors.

[0048] Figure 10 is a schematic diagram of a chemiluminescence immunoassay analyzer structure according to an embodiment of the present application. As shown in Figure 10 The chemiluminescence immunoassay analyzer 1000 includes at least an incubation device 100, a tube library unit 200, a sample library unit 300, a washing unit 400, a detection unit 500, a reagent bin 700, and a plurality of grippers 600. The incubation device 100 includes a heating device that can provide a constant temperature environment for the reaction tube containing the sample and the reagent, accelerating the reaction of the sample and the reagent. Specifically, first, the reaction tube on the tube library unit 200 is moved to the reaction tube placement position 136 of the incubation device 100, and the reaction tube on the reaction tube placement position 136 is rotated to the sample library unit 300 and the reagent bin 700, respectively, to add the sample and the reagent and mix them. Then, the reaction tube is moved from the reaction tube placement position 136 to the incubation assembly 120, and when the incubation is completed, the reaction tube is moved from the incubation assembly 120 to the washing unit 400 for washing operation. Finally, the reaction tube is moved from the washing unit 400 to the detection unit 500 to detect the light value of the sample and reagent combination, and when the detection is completed, the reaction tube is moved to the waste channel.

[0049] In the normal detection process of the chemiluminescence immunoassay analyzer, after the detection is completed, the incubation unit, the cleaning unit and the detection unit will have no reaction tube, so as to prepare for the next detection. However, in the detection process, when an abnormal situation occurs, such as power failure or fault, the self-checking program needs to be performed again to clean the reaction tube placed on the incubation unit, the cleaning unit and the detection unit. The present application proposes a new self-checking method, and the specific content is as follows:

[0050] Figure 11 The self-checking method of the chemiluminescence immunoassay analyzer according to an embodiment of the present application. In step S110, the processing ring assembly is controlled to rotate, and the second sensor is used to detect whether there is a reaction tube on the processing ring assembly.

[0051] In step S120, in response to the detection of the reaction tube by the second sensor, the reaction tube is moved from the processing ring assembly to the waste channel by the second gripper.

[0052] In step S130, the incubation disc is controlled to rotate, and the first sensor is used to detect whether there is a reaction tube on the incubation disc.

[0053] In step S140, in response to the detection of the reaction tube by the first sensor, the reaction tube is moved from the incubation disc to the processing ring assembly by the first gripper. In an embodiment, when the first sensor detects multiple hole positions at the same time, the first sensor can determine the positions of the hole positions according to the detection signals. In another embodiment, when the first sensor detects multiple hole positions at the same time, the first gripper sequentially grasps the multiple hole positions.

[0054] In step S150, the processing ring assembly is controlled to rotate, and the second sensor is used to detect whether there is a reaction tube on the processing ring assembly.

[0055] In step S160, in response to the detection of the reaction tube by the second sensor, the reaction tube is moved from the processing ring assembly to the waste channel by the second gripper.

[0056] In summary, by installing the first sensor and the second sensor in the incubation device, the present application can detect whether there is a reaction tube on the incubation disc and the processing ring assembly, respectively. By using the rotation function of the incubation disc and the processing ring assembly, the detection time can be shortened, and the work efficiency can be improved. Moreover, by controlling the working order of the first sensor and the second sensor, the work flow is optimized, the problem of missed detection is avoided, and the self-checking accuracy is improved, thereby improving the working stability of the chemiluminescence immunoassay analyzer.

[0057] The above embodiments are only used to illustrate the present application, but not to limit the present application. Those skilled in the art can make various changes and modifications without departing from the scope of the present application. Therefore, all equivalent technical solutions shall belong to the scope disclosed by the present application.

Claims

1. A method for self-testing a chemiluminescence immunoassay analyzer, wherein the chemiluminescence immunoassay analyzer comprises: The system comprises a storage unit, a cleaning unit, a detection unit, and an incubation device, wherein the incubation device includes: The main body of warm nurturing; An incubation assembly includes: a housing disposed on the incubation body; an incubation tray disposed inside the housing and rotating about the axis of the housing, the incubation tray having multiple holes for supporting reaction tubes arranged in a ring on the incubation tray; a first sensor disposed on the housing for detecting whether a reaction tube is placed on the incubation tray; a heating assembly disposed inside the housing for maintaining a stable internal temperature of the incubation assembly; and a processing ring assembly disposed outside the incubation assembly and rotating about it, the processing ring assembly including multiple reaction tube placement positions. The outer shell includes an inner layer, which is annular and protrudes from the bottom of the outer shell; the first sensor is installed inside the multiple annular rings, and through holes for signal detection are opened at corresponding positions in the inner layer; The heating assembly includes: a heating module; a heat-conducting module disposed on the heating module; the heat-conducting module is an annular U-shaped groove, which has a groove for passing a detection signal near the first sensor; the first sensor is a photoelectric sensor, including a correspondingly disposed transmitting end and receiving end, and the groove is disposed correspondingly to the transmitting end; the first sensor and a hole in the same radial direction are correspondingly disposed. A second sensor, disposed on the incubation body, is used to detect whether the reaction tube is placed in the processing ring assembly; and A control unit, in response to the first sensor and / or the second sensor detecting the reaction tube, controls one or more grippers to move the reaction tube into the processing ring assembly and / or the waste channel; The self-testing process using the chemiluminescence immunoassay analyzer includes the following steps: The processing ring assembly is controlled to rotate, and the second sensor is used to detect whether the reaction tube is on the processing ring assembly; In response to the second sensor detecting the reaction tube, the second gripper moves the reaction tube from the processing ring assembly to the waste channel, the incubation tray is rotated, and the first sensor is used to detect whether the reaction tube is on the incubation tray. In response to the first sensor detecting the reaction tube, the first gripper moves the reaction tube from the incubation tray to the processing ring assembly; Controlling the rotation of the processing ring assembly and using the second sensor to detect whether the reaction tube is present on the processing ring assembly; and In response to the second sensor detecting the reaction tube, the second gripper moves the reaction tube from the processing ring assembly to the waste channel.

2. The method according to claim 1, characterized in that, The first sensor is positioned within the multiple rings to simultaneously detect the placement status of the reaction tubes in the multiple orifices.

3. The method according to claim 1, characterized in that, The number of reaction tube placement positions is 6-15.

4. The method according to claim 1, characterized in that, The incubation component also includes: A top cover, which is disposed on the outer casing, having one or more elliptical holes for the reaction tube to pass through during insertion or removal; and Insulating cotton is applied to the inner wall of the outer shell; When the top cover is placed on the outer shell, the outer shell, the inner layer, the top cover, and the insulation cotton form an insulation space.

5. The method according to claim 1, characterized in that, The heating component includes: A temperature sensor, electrically connected to the control unit, for transmitting a temperature detection signal; and A temperature control switch is electrically connected to the control unit to receive a switch command and control the temperature control switch to turn the heating module on or off according to the temperature detection signal.

6. The method according to claim 1, characterized in that, The system further includes a mixing device disposed on the incubation body and located below the processing ring assembly. The mixing device is used to rotate the reaction tube to mix the liquid in the reaction tube. The mixing device includes: Mixing seat; A mixing motor is mounted on the mixing base, and the mixing motor provides power to rotate the reaction tube. A mixing block, wherein the mixing block is disposed on the rotor of the mixing motor, and the top surface of the mixing block has a blind hole for accommodating the reaction tube; and A lead screw motor is movably connected to the mixing seat, and the lead screw motor is used to drive the mixing block to move in the vertical direction.

7. The method according to claim 6, characterized in that, The blind hole is located at an off-center position on the mixing block, and the opening of the blind hole is funnel-shaped.

8. The method according to claim 1, characterized in that, The incubation body includes a first reset sensor, and the processing ring assembly includes a first trigger plate. In response to the end of the chemiluminescence immunoassay analyzer detection program, when the processing ring assembly rotates to the position where the first reset sensor detects the first trigger plate, the control unit controls the processing ring assembly to stop rotating.

9. The method according to claim 6, characterized in that, The mixing device further includes a second reset sensor and a second trigger plate. The second reset sensor is disposed on the mixing seat, and the second trigger plate is disposed on the mixing block. In response to the end of the chemiluminescence immunoassay analyzer detection program, when the mixing block rotates to the position where the second reset sensor detects the second trigger plate, the mixing block stops rotating.

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