Precise corneal cross-linking astigmatism correction system guided by corneal topography

Abstract

A visual and precise corneal cross-linking astigmatism correction system guided by corneal topography imaging includes a cross-linking treatment module, a real-time detection module and a control module. The cross-linking treatment module is used to output a light spot for realizing corneal cross-linking treatment. The real-time detection module is used to detect the eye morphology and corneal topography imaging during treatment in real time in synchronization with the cross-linking treatment, and dynamically locate the astigmatism treatment axis according to the real-time detected corneal topography changes. The control module generates a corneal cross-linking pattern scheme according to the corneal topography detected and imaged in real time by the real-time detection module and the dynamically located astigmatism treatment axis, and controls the cross-linking treatment module to output the light spot according to the corneal cross-linking pattern scheme, thereby realizing corneal cross-linking astigmatism correction guided by corneal topography imaging. During the cross-linking treatment process, the corneal topography changes are detected in real time, the astigmatism treatment axis is accurately located, and the treatment pattern is dynamically and real-time output accordingly, which greatly improves the accuracy of the cross-linking output pattern and can achieve better surgical treatment effects.

Description

Technical Field

[0001] The present invention relates to an ophthalmic surgery system, and in particular to a precise corneal cross-linking astigmatism correction system guided by corneal topography imaging. Background Art

[0002] Astigmatism is a common refractive error. It refers to the fact that after a point light source emits a light beam into the eye, it cannot be focused on one point (focus) due to the different refractive powers of the eyeball on different meridians. Instead, it forms a diffuse spot on the retina, so a clear image cannot be produced. Astigmatism affects the patient's vision and quality of life, and has become an increasingly serious public health problem. Human eye astigmatism is mainly composed of corneal astigmatism and lens astigmatism, among which corneal astigmatism plays a decisive role. The shape of the cornea directly affects eye astigmatism. On a flat meridian, the corneal curvature is small, the radius of curvature is large, the refractive power is small, and the imaging position is posterior; on a steep meridian, the corneal curvature is large, the radius of curvature is small, the refractive power is large, and the imaging position is anterior. Therefore, permanent astigmatism correction surgery currently also acts on the cornea. Corneal topography can detect the radius of curvature and refractive power of each point on the cornea, and is often used to guide astigmatism correction. However, the corneal topography used as a reference in current clinical treatment is measured before treatment, rather than after the patient and treatment equipment are positioned. Therefore, precise calibration of the axis of astigmatism treatment has not yet been achieved.

[0003] Existing methods for correcting astigmatism include: wearing frame glasses, wearing contact lenses, laser in situ keratomileusis and other corneal laser surgeries, intraocular refractive surgery, and astigmatic keratotomy. (1) Wearing frame glasses and contact lenses is the treatment method currently chosen by most patients. They can effectively correct astigmatism, but frame glasses cannot work well on rainy days, in scenes with large changes in temperature and humidity, and in sports scenes. Contact lenses are inconvenient to wear and can easily cause ocular discomfort symptoms such as dry eyes and eye pain. They are not suitable for patients with dry eyes; (2) Corneal laser surgery uses laser cutting or ablation of the corneal stroma layer, removing or destroying the stroma tissue, reducing the corneal tissue in the target area, thereby flattening the cornea in that area and changing the corneal curvature to achieve the effect of correcting astigmatism. However, this type of surgery is often destructive. While correcting astigmatism, it also causes permanent loss of corneal tissue and may even lead to changes in corneal biomechanics, which can easily lead to postoperative complications such as corneal ectasia and dry eyes. (3) Intraocular refractive surgery is an invasive intraocular surgery that corrects astigmatism by implanting an astigmatism-correcting intraocular lens. However, since it is an intraocular surgery, there are risks such as endophthalmitis. (4) Astigmatic keratotomy corrects astigmatism by making a non-penetrating incision in the peripheral cornea on the steep meridian, causing the corneal surface to expand and relax, making the steep meridian flatter. This procedure is convenient and low-cost, but it lacks predictability, and the corneal incision also destroys the mechanical stability of the cornea. Therefore, finding a new non-invasive and stable astigmatism correction technology will help to break through the limitations of existing technologies.

[0004] Corneal collagen cross-linking is a method used clinically to treat keratoconus, and in recent years it has also been found to have the potential to treat myopia. The basic principle of corneal cross-linking therapy is that the photosensitizer riboflavin produces oxygen free radicals under the stimulation of ultraviolet light, which then induces and catalyzes the oxidative cross-linking between collagen fibers in the corneal stroma, thereby increasing the diameter and hardness of the fibers. The cross-linking of collagen fibers can not only enhance the hardness of the cornea, but also change the traction between the stroma layers, thereby bringing about changes in the microstructure and surface morphology of the cornea. Therefore, it is possible to change the surface morphology of the target corneal area in this way, and change the refractive power of the cornea by changing the curvature of the corneal surface. However, the existing corneal cross-linking technology uses traditional circular light spots to perform full corneal cross-linking, so it is impossible to change the corneal curvature of the steep meridian or flat meridian in a targeted manner, and is not suitable for astigmatism correction. Moreover, during the treatment process, it is impossible to observe the cross-linking effect and corneal topography changes in real time. Changes in the patient's body position and eye position may also lead to inaccurate positioning and affect the treatment effect. Formulating a new corneal cross-linking treatment model and introducing a real-time monitoring module, and developing a visual precise corneal cross-linking astigmatism correction system guided by corneal topography imaging will be able to achieve non-invasive and stable astigmatism correction.

[0005] The disclosure of the above background technology content is only used to assist in understanding the inventive concept and technical solution of the present invention. It does not necessarily belong to the prior art of this patent application. In the absence of clear evidence that the above content has been disclosed on the filing date of this patent application, the above background technology should not be used to evaluate the novelty and creativity of the present application. Summary of the invention

[0006] The main purpose of the present invention is to overcome the defects of the above-mentioned background technology and provide a visual precise corneal cross-linking astigmatism correction system guided by corneal topography imaging, so as to improve the accuracy of the cross-linking output pattern in astigmatism correction surgery and achieve better treatment effect.

[0007] To achieve the above object, the present invention adopts the following technical solutions:

[0008] A visualized precise corneal cross-linking astigmatism correction system guided by corneal topography imaging comprises a cross-linking treatment module, a real-time detection module and a control module, wherein the cross-linking treatment module is used to output a light spot for realizing corneal cross-linking treatment, the real-time detection module is used to synchronously detect the eye morphology and corneal topography imaging during treatment in real time with the cross-linking treatment, and dynamically locate the astigmatism treatment axis according to the real-time detected corneal topography changes, the control module generates a corneal cross-linking pattern scheme according to the corneal topography detected and imaged in real time by the real-time detection module and the dynamically located astigmatism treatment axis, and controls the cross-linking treatment module to output the light spot according to the corneal cross-linking pattern scheme, thereby realizing corneal cross-linking astigmatism correction guided by corneal topography imaging.

[0009] Furthermore, the cross-linking therapy module includes an ultraviolet light source, and the real-time detection module includes a white light source. The control module controls the ultraviolet light source and the white light source to emit ultraviolet light and white light alternately in pulses, so that the cross-linking therapy and real-time detection are performed alternately and synchronously.

[0010] Furthermore, under the control of the control module, the white light source of the real-time detection module outputs a placido ring image projection in a pulsed manner, and the placido ring image is a concentric ring image with alternating light and dark.

[0011] Furthermore, the real-time detection module includes an imaging unit and an image processing unit, the imaging unit collects the placido ring image projection formed by the white light source, the image processing unit analyzes the placido ring image projection in real time, selects the points of the placido ring image projection on 360 semi-meridians, calculates the position change of each point by comparing the preset data in the database, performs spherical fitting, and calculates the relative height, curvature radius and curvature of each cornea point compared with the standard sphere with a 240*240 dot matrix to generate corneal topography. Preferably, the corneal topography includes a corneal anterior surface height map and a corneal anterior surface tangential curvature map.

[0012] Furthermore, the imaging unit includes four cameras, which are respectively located at 12 o'clock, 3 o'clock, 6 o'clock, and 9 o'clock above the eyeball, and are used to capture the eyeball morphology and the placido ring image projection.

[0013] Furthermore, a cross-linking pattern is designed based on the corneal anterior surface height map, wherein a circular ring with a diameter of 4 mm to 9 mm centered on the pupil is selected, and the area formed by points within the circular ring whose relative height is greater than zero, that is, whose absolute height is higher than that of a standard eye, is defined as the cross-linking pattern.

[0014] Furthermore, during the cross-linking treatment, the UV light is projected in a pulsed manner with a cross-linking pattern of 1 second on and 1 second off, and the cross-linking energy is 0-30 mW / cm 2 , the oxygen concentration is greater than or equal to 95%, wherein the cross-linking energy is determined according to the relative height range of the anterior surface of the cornea in the cross-linking area and the degree of corneal astigmatism; when performing real-time detection, the white light is projected in a pulsed output of placido ring image with a speed of 1 second off and 1 second on.

[0015] Furthermore, the cross-linking treatment module includes an oxygen supply unit, which includes an oxygen supply eye mask, an output pipe, an oxygen generating device, and an oxygen concentration detection device, which is used to complete the continuous output of oxygen and real-time concentration detection during the treatment process, so that the oxygen concentration during the treatment process is greater than or equal to 95%.

[0016] Furthermore, the control module is a control storage module, and the control storage module also stores the eye morphology and corneal topography imaging changes recorded by the real-time detection module in the form of video and / or picture.

[0017] Furthermore, it also includes a display unit for displaying the eye morphology and corneal topography before, during and after treatment.

[0018] The present invention has the following beneficial effects:

[0019] The visualized precise corneal cross-linking astigmatism correction system provided by the present invention has the following characteristics: when the cross-linking treatment module outputs a light spot for realizing corneal cross-linking treatment, the real-time detection module synchronously detects the eye morphology and corneal topography imaging in real time, and dynamically locates the astigmatism treatment axis according to the real-time detected corneal topography changes; the control module generates a corneal cross-linking pattern scheme according to the real-time detected imaging corneal topography and the dynamically located astigmatism treatment axis, and controls the cross-linking treatment module to output the light spot according to the corneal cross-linking pattern scheme, thereby realizing corneal cross-linking astigmatism correction guided by corneal topography imaging. Therefore, the present invention overcomes the problems that the existing corneal cross-linking system cannot meet the astigmatism correction needs, cannot accurately locate the astigmatism treatment axis in real time, and cannot dynamically control the cross-linking pattern according to the real-time treatment effect; while performing cross-linking treatment, the corneal topography changes are detected in real time and the astigmatism treatment axis is accurately located to dynamically generate a corneal cross-linking pattern scheme, and finally complete non-invasive and precise astigmatism correction.

[0020] The astigmatism correction system provided by the present invention can integrate corneal cross-linking treatment and corneal topography detection, complete the in-situ combination of the two, detect corneal topography changes in real time during the cross-linking treatment, accurately locate the astigmatism treatment axis, and dynamically output the treatment pattern in real time based on this, thereby reducing the positioning deviation caused by changes in patient position, eye rotation, etc. during the detection and treatment process, and perform cross-linking astigmatism correction under the guidance of corneal topography imaging, which greatly improves the accuracy of the cross-linking output pattern, can achieve better surgical treatment effects, and provides the possibility of accurate and personalized cross-linking treatment of astigmatism.

[0021] Furthermore, by using the visualized astigmatism correction system of the present invention, the doctor can observe the changes in corneal topography in real time during the treatment process and monitor the treatment process, which helps to ensure the safety and effectiveness of the surgical process.

[0022] Furthermore, the present invention can also record the changes in eye appearance and corneal morphology during the operation in the form of images and videos, which can be traced and used for subsequent retrospective observation of changes in the patient's corneal topography during the operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 A structural block diagram of a visual precise corneal cross-linking astigmatism correction system guided by corneal topography imaging according to an embodiment of the present invention;

[0024] Figure 2 A component diagram of a visual precise corneal cross-linking astigmatism correction system guided by corneal topography imaging according to an embodiment of the present invention;

[0025] Figure 3 A schematic diagram of the steps of a visual precise corneal cross-linking astigmatism correction system guided by corneal topography imaging according to an embodiment of the present invention;

[0026] Figure 4 This is a diagram of the animal experiment results of a visualized precise corneal cross-linking astigmatism correction system guided by corneal topography imaging according to an embodiment of the present invention. DETAILED DESCRIPTION

[0027] The following is a detailed description of the embodiments of the present invention. It should be emphasized that the following description is only exemplary and is not intended to limit the scope and application of the present invention.

[0028] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it can be directly on the other element or indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element. In addition, connection can be used for fixing as well as for coupling or communication.

[0029] It should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the embodiments of the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0030] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the embodiments of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0031] See also Figures 1 to 3An embodiment of the present invention provides a visual precise corneal cross-linking astigmatism correction system guided by corneal topography imaging, comprising a cross-linking treatment module, a real-time detection module and a control module, wherein the cross-linking treatment module is used to output a light spot for realizing corneal cross-linking treatment, the real-time detection module is used to synchronously detect the eye morphology and corneal topography imaging during treatment in real time with the cross-linking treatment, and dynamically locate the astigmatism treatment axis according to the real-time detected corneal topography changes, the control module generates a corneal cross-linking pattern scheme according to the corneal topography detected and imaged in real time by the real-time detection module and the dynamically located astigmatism treatment axis, and controls the cross-linking treatment module to output the light spot according to the corneal cross-linking pattern scheme, thereby realizing corneal cross-linking astigmatism correction guided by corneal topography imaging.

[0032] In a preferred embodiment, the cross-linking therapy module includes an ultraviolet light source, and the real-time detection module includes a white light source. The control module controls the ultraviolet light source and the white light source to emit ultraviolet light and white light alternately in pulses, so that the cross-linking therapy and real-time detection are performed alternately and synchronously.

[0033] During the working process, the cross-linking treatment module outputs a light spot for achieving corneal cross-linking treatment, the real-time detection module synchronously detects the eye morphology and corneal topography during treatment, and dynamically locates the astigmatism treatment axis according to the real-time detected corneal topography changes, the control module dynamically generates a corneal cross-linking pattern scheme in real time according to the real-time detected corneal topography and the dynamically located astigmatism treatment axis, and controls the cross-linking treatment module to output the light spot according to the corneal cross-linking pattern scheme, thereby completing corneal cross-linking astigmatism correction guided by corneal topography imaging. According to this scheme, the corneal topography changes are synchronously detected in real time during cross-linking treatment and the astigmatism treatment axis is accurately located to dynamically generate a corneal cross-linking pattern scheme, thereby achieving accurate non-invasive astigmatism correction.

[0034] During the cross-linking treatment process, the system detects corneal topography changes in real time and accurately locates the astigmatism treatment axis, and dynamically outputs the treatment pattern in real time based on this, thereby reducing the positioning deviation caused by changes in patient position, eye rotation, etc. during the detection and treatment process. Cross-linking astigmatism correction is performed under the guidance of corneal topography imaging, which greatly improves the accuracy of the cross-linking output pattern, achieves better surgical treatment effects, and provides the possibility of accurate and personalized cross-linking treatment of astigmatism.

[0035] This visual precise corneal cross-linking astigmatism correction system guided by corneal topography imaging integrates corneal cross-linking treatment and corneal topography detection to achieve precise astigmatism correction that is non-invasive, stable, convenient, individualized, predictable, traceable, and can enhance the mechanical stability of the cornea.

[0036] In some embodiments, a visual precise corneal cross-linking astigmatism correction system guided by corneal topography imaging includes a cross-linking treatment module, a real-time detection module and a control storage module. The cross-linking treatment module is used to project a pulsed output of a customized corneal cross-linking light spot. The real-time detection module is used to detect and display the eye morphology and corneal topography before, during and after treatment in real time. The corneal topography is achieved by analyzing the placido ring image projected on the cornea. The control storage module automatically generates a customized corneal cross-linking pattern plan based on the corneal height map formed by the real-time detection module, and then outputs the light spot for treatment through the cross-linking treatment module. In addition, the control storage module also stores the eye morphology and corneal topography changes recorded by the real-time detection module in the form of surgical videos and pictures.

[0037] In some embodiments, the cross-linking treatment module includes the ultraviolet light part 11 in the light source unit 1 and the oxygen supply unit 2, the real-time detection module includes the white light part 12 in the light source unit 1, the imaging unit 3, the image processing unit 4 and the display unit 5, and the control storage module includes a control unit 6 and a storage unit 7. The control unit 6 controls the light beam output of the light source unit 1, the image integration and corneal topography imaging analysis of the image processing unit 4, the information storage of the storage unit 7, the oxygen output of the oxygen supply unit 2, etc.

[0038] In some embodiments, the light source unit 1 includes a digital light projection chip with a micro-mirror array, which can subdivide the collimated light beam into small light beams, and under the control of the control unit 6, select to reflect or not reflect each small light beam in a set manner, and finally form a preset light beam projection on the cornea. The collimated light beam is a light beam emitted by the optical machine and collimated by a collimating lens, including an ultraviolet light part 11 for cross-linking treatment and a white light part 12 for real-time detection, both of which can emit light in pulsed / non-pulsed mode.

[0039] In some embodiments, during cross-linking treatment, the control unit 6 controls the ultraviolet light of the light source unit 1 to be pulsed (on for 1 second, off for 1 second) to output customized treatment pattern projection, with energy of 0-30 mW / cm 2 , oxygen concentration is greater than or equal to 95%.

[0040] In some embodiments, when performing real-time detection, the control unit 6 controls the white light of the light source unit 1 to output a placido ring image projection in a pulsed manner (off for 1 second, on for 1 second).

[0041] Therefore, the ultraviolet light and white light under the control of the control unit 6 are output alternately in pulses, that is, the cross-linking treatment and the real-time detection do not conflict with each other, are performed alternately and completed synchronously, thereby achieving real-time and accurate positioning of the astigmatism treatment axis and real-time detection of the treatment effect.

[0042] In some embodiments, when real-time detection is performed, white light is pulsed (off for 1 second, on for 1 second) to output placido ring image projection, and the placido ring image is a concentric ring of light and dark. When the radius of the corneal surface is a standard spherical surface of 7.94, at the accurate focus position, the projection of the placido image output by the light source unit 1 on the corneal surface is a concentric ring of light (white light) and dark with equal width and equal interval. If the corneal surface deviates from the standard spherical surface, the position of the formed projection ring changes, and the image processing unit 4 can compare the position change of each point on the ring with the database for analysis and calculation to obtain the corneal morphology.

[0043] In some embodiments, the imaging unit 3 includes four cameras 31, 32, 33, and 34, which are respectively located at 12 o'clock, 3 o'clock, 6 o'clock, and 9 o'clock above the eyeball to collect the eyeball morphology and corneal surface projection images.

[0044] In some embodiments, the image processing unit 4 includes two functions: image integration and corneal topography imaging analysis. The image collected by the imaging unit 3 is integrated to reduce imaging errors, and the corneal projection formed by the white light part 12 of the light source unit 1 is analyzed. The points of the placido projection on the 360 ​​semi-meridians are selected, and the position changes of each point are calculated by comparing with the database. Spherical fitting is performed through a built-in program, and the relative height of the cornea at each point (compared with the standard sphere), the radius of curvature and the curvature are calculated with a 240*240 dot matrix to generate the corneal topography, including but not limited to the corneal anterior surface height map and the corneal anterior surface tangential curvature map.

[0045] In some embodiments, the eye morphology and corneal topography obtained by analysis after integration by the image processing unit 4 are visualized on the display screen 51 of the display unit 5, allowing doctors to observe and monitor in real time during the surgical treatment.

[0046] In some embodiments, when performing cross-linking treatment, the control unit 6 automatically generates a cross-linking pattern based on the corneal topography obtained by analyzing the image processing unit 4 of the real-time detection module through a built-in program, and controls the ultraviolet light beam output of the light source unit 1, thereby completing the corneal cross-linking astigmatism correction guided by corneal topography imaging. The corneal cross-linking astigmatism correction guided by corneal topography imaging is specifically configured as follows in this system: the built-in program designs a cross-linking pattern based on the patient's corneal anterior surface height map, selects a circular ring with a diameter of 4mm to 9mm with the pupil as the center, and the area formed by each point within this circular range whose relative height is greater than zero (i.e., the absolute height is higher than the standard eye) is defined as the cross-linking pattern, and the cross-linking energy is 0-30 mW / cm 2The specific output energy is determined by the built-in program according to the relative height range and corneal astigmatism degree in the cross-linked area. The ultraviolet light is pulsed (on for 1 second, off for 1 second), and the treatment time is 1000 seconds. When outputting the cross-linked pattern ultraviolet light beam, the control unit 6 can realize real-time eye tracking and positioning through the real-time detection module, and accurately locate the astigmatism treatment axis. The storage unit 7 stores the eye morphology and corneal topography obtained by the analysis of the image processing unit 4 in the form of surgical videos and pictures, which can complete the recording of the surgical process and provide postoperative retrieval, viewing and analysis.

[0047] In some embodiments, the oxygen supply unit 2 is composed of an oxygen supply eye mask, an output pipe, an oxygen generating device, and an oxygen concentration detection device, which completes the continuous output of oxygen and real-time detection of concentration during the treatment process, ensuring that the oxygen concentration during the treatment is greater than or equal to 95%, and improving the cross-linking effect with a high oxygen environment, thereby allowing the surgery to retain the corneal epithelium to reduce postoperative discomfort.

[0048] The features, principles and advantages of specific embodiments of the present invention are further described below in conjunction with the accompanying drawings.

[0049] See also Figure 1 to Figure 2 In one embodiment, a visual accurate corneal cross-linking astigmatism correction system guided by corneal topography imaging includes a cross-linking treatment module, a real-time detection module and a control storage module. The cross-linking treatment module is composed of an ultraviolet light part 11 in a light source unit 1 and an oxygen supply unit 2. The module is used to project pulsed output of customized corneal cross-linking light spots. The real-time detection module is composed of a white light part 12 in a light source unit 1, an imaging unit 3, an image processing unit 4, and a display unit 5. The module is used to detect and display the eye morphology and corneal topography before, during and after treatment in real time. The corneal topography is achieved by analyzing the placido ring image projected on the cornea. The control storage module is composed of a control unit 6 and a storage unit 7. The module can automatically generate a customized corneal cross-linking pattern scheme according to the corneal height map formed by the real-time detection module, and then output the light spot for treatment through the cross-linking treatment module. In addition, the module also stores the changes in eye morphology and corneal topography recorded by the real-time detection module in the form of surgical videos and pictures.

[0050] By detecting topographic changes in real time during the treatment process, accurately positioning the astigmatism treatment axis, and dynamically outputting the treatment pattern in real time, it is possible to reduce positioning errors caused by changes in patient position and eye rotation during the detection and treatment process, and perform cross-linking astigmatism correction under the guidance of corneal topography imaging, greatly improving the accuracy of the cross-linking output pattern and achieving better surgical treatment results.

[0051] See also Figures 1 to 3In a preferred embodiment, the light source unit 1 includes a digital light projection chip 13 having a micro-mirror array, which can subdivide the collimated light beam into small light beams, and under the control of the control unit 6, select to reflect or not reflect each small light beam in a set manner, and finally form a preset light beam projection on the cornea. The collimated light beam is a light beam emitted by the optical machine and collimated by a collimating lens, including an ultraviolet light part 11 for cross-linking treatment and a white light part 12 for real-time detection, both of which can emit light in pulsed / non-pulsed mode.

[0052] In a preferred embodiment, the patient is in a supine position for surgical treatment. After completing a series of preoperative preparations such as body positioning, disinfection and draping, and riboflavin soaking (reference scheme: 0.25% riboflavin solution, dripped once every 90 seconds for 4 minutes; then rinsed the ocular surface with 0.22% riboflavin solution, and continued to drip at the same rate for 6 minutes), the preoperative corneal topography detection step is performed in the system, and the detection is completed by the real-time detection module. At this time, the white light part 12 in the light source unit 1 is a non-pulsed (continuous) output placido ring image projection, and the placido ring image is a concentric ring of light and dark. When the radius of the corneal surface is a standard spherical surface of 7.94, at the accurate focus position, the projection of the placido image output by the light source unit 1 on the corneal surface is a concentric ring of light (white light) and dark with equal width and equal interval; if the corneal surface deviates from the standard spherical surface, the position of the formed projection ring changes, and the corneal topography can be calculated by comparing the position changes of each point on the ring with the database analysis. The imaging unit 3 collects the ocular morphology and the placido imaging projection formed by the corneal surface. The unit is composed of four cameras. The cameras 31, 32, 33, and 34 are respectively located at 12 o'clock, 3 o'clock, 6 o'clock, and 9 o'clock above the eyeball, and can collect the ocular morphology and corneal surface projection images. Further, the image processing unit 4 integrates the images collected by the imaging unit 3 to reduce the imaging error, and analyzes the corneal projection formed by the white light part 12 of the light source unit 1, selects the points of the placido projection on the 360 ​​semi-meridians, compares the database to calculate the position change of each point, performs spherical fitting through the built-in program, calculates the relative height of the cornea (compared with the standard sphere), the radius of curvature, and the curvature of each point in the cornea with a 240*240 dot matrix, generates the corneal topography, and visualizes the corneal topography obtained by the analysis on the display screen 51 through the display unit 5, including but not limited to the corneal anterior surface height map and the corneal anterior surface tangential curvature map. The generated corneal topography will serve as a blueprint for the system to customize personalized and precise corneal cross-linking astigmatism correction solutions, based on which subsequent visual astigmatism correction guided by corneal topography imaging will begin.

[0053] In a preferred embodiment, after completing the preoperative corneal topography detection, the next step is to perform a visual accurate corneal cross-linking astigmatism correction step. At this time, the control unit 6 can design a cross-linking pattern based on the patient's corneal anterior surface height map through a built-in program, select a circular ring with a diameter of 4mm to 9mm with the pupil as the center, and the area formed by each point within this circular range with a relative height greater than zero (i.e., an absolute height higher than a standard eye) is defined as a cross-linking pattern, and the cross-linking energy is 0-30 mW / cm 2 A certain value in (the specific output energy is determined by the built-in program according to the relative height range and corneal astigmatism degree in the cross-linking area). Then, the purple light part 11 in the light source unit 1, under the control of the control unit 6, emits light in a pulsed manner (on for 1 second, off for 1 second) in the pattern designed by the aforementioned built-in program, thereby forming a corresponding corneal surface ultraviolet light projection at the accurate focus position, and an ultraviolet light-riboflavin-corneal oxidation cross-linking reaction occurs in the designated area to treat astigmatism, and the treatment time is 1000 seconds. Further, during the treatment process, real-time corneal topography detection can be completed at the same time. The white light part in the light source unit 1, under the control of the control unit 6, emits light in a pulsed manner (off for 1 second, on for 1 second) in the form of a placido ring image, thereby forming a placido ring image projection at the accurate focus position. The cameras 31, 32, 33, and 34 of the imaging unit 3 jointly complete the acquisition of eye morphology and placido imaging projection, and the image processing unit 4 integrates and analyzes the comparison database to calculate the corneal relative height, curvature radius and curvature, and generates corneal topography in real time. Furthermore, the control unit 6 automatically generates a cross-linking pattern synchronously based on the corneal topography obtained through the built-in program, and performs eye tracking positioning, and accordingly adjusts the ultraviolet light beam output of the light source unit 1 to achieve accurate positioning of the astigmatism treatment axis, and completes the accurate corneal cross-linking astigmatism correction guided by corneal topography imaging. Therefore, the ultraviolet light and white light under the control of the control unit appear alternately in pulses, that is, the cross-linking treatment and real-time detection do not conflict with each other, but are performed alternately and synchronously, thereby achieving real-time accurate positioning of the astigmatism treatment axis and real-time detection of the treatment effect.

[0054] In a preferred embodiment, after the treatment, the postoperative corneal topography detection step is performed, and the corneal topography detection is also performed in the above-mentioned manner to observe the final treatment effect.

[0055] In a preferred embodiment, the system further includes an oxygen supply unit 2, which is composed of an oxygen supply eye mask 21, an output pipe 22, an oxygen generating device 23, and an oxygen concentration detection device 24. The oxygen supply unit 2 is continuously output and the concentration is detected in real time during the whole treatment process, so as to ensure that the oxygen concentration is greater than or equal to 95% during the treatment process, and to improve the cross-linking effect with a high oxygen environment, thereby allowing the surgery to retain the corneal epithelium to reduce postoperative discomfort. The oxygen supply unit 2 also works under the control of the built-in program of the control unit 6.

[0056] In a preferred embodiment, during the treatment process, the display unit 5 can also visualize the eye morphology and corneal topography obtained by the image processing unit 4 in real time for the surgeon to observe and monitor in real time. The display unit 5 also works under the control of the built-in program of the control unit 6.

[0057] In a preferred embodiment, the system further includes a storage unit 7, which stores the eye morphology and corneal topography obtained by the image processing unit in the form of surgical videos and pictures, including pre-operative, intra-operative and post-operative, and can complete the recording of the surgical process and provide long-term post-operative viewing and analysis. The storage unit 7 also works under the control of the built-in program of the control unit 6.

[0058] In other embodiments, the modified scheme may be that the corneal topography detection is not performed again after the operation, or there is no oxygen supply unit, or there is no real-time visualization of the eye morphology and corneal topography, or there is no storage unit, etc.

[0059] In addition, other embodiments may also include setting an energy density gradient for the treatment pattern, forming an ultraviolet light beam projection with an energy density gradient on the cornea, stimulating riboflavin to produce free radicals, and catalyzing the oxidative cross-linking between collagen fibers in the corneal stroma layer at different locations to varying degrees.

[0060] Figure 4 The animal experiment results of the visual precise corneal cross-linking astigmatism correction system guided by corneal topography imaging according to an embodiment of the present invention are shown.

[0061] Advantages of the embodiments of the present invention include:

[0062] a. Integration of corneal cross-linking therapy and corneal topography detection: Complete the in-situ combination of corneal cross-linking therapy and corneal topography detection, perform topography detection before treatment to complete the initial cross-linking plan setting, detect topography changes in real time during treatment, accurately locate the astigmatism treatment axis, and dynamically output the treatment pattern in real time based on this, thereby reducing the positioning deviation caused by changes in patient position and eye rotation during the detection and treatment process, and perform cross-linking astigmatism correction under the guidance of corneal topography imaging, which greatly improves the accuracy of the cross-linking output pattern, can achieve better surgical treatment effects, and provides the possibility of accurate and personalized cross-linking treatment of astigmatism.

[0063] b. Correction of astigmatism through corneal cross-linking: There is still no specific implementation method for correcting astigmatism through corneal cross-linking. Based on the existing experimental results, the present invention concretizes a system and method for non-invasive correction of astigmatism through corneal cross-linking, achieving a breakthrough in non-invasive correction of astigmatism.

[0064] c. Individualization: Through the built-in treatment plan design algorithm, individualized and customized treatment plans can be designed in real time based on the patient's corneal topography.

[0065] d. Dynamic corneal imaging-guided treatment: The astigmatism treatment axis is accurately positioned based on real-time detected terrain changes, and the treatment pattern is dynamically output in real time to achieve precise cross-linking guided by dynamic corneal imaging.

[0066] e. Visualization: During the treatment process, the changes in eye morphology and corneal topography are visualized in real time, so the surgeon can observe and monitor the entire process, and dual human-machine monitoring is used to improve the precision and accuracy of the treatment.

[0067] f. Recordable and traceable: This system can store the eye morphology before, during and after treatment and the analyzed corneal topography in the form of surgical videos and pictures, which can complete the record of the surgical process and provide long-term retrieval, viewing and analysis after surgery.

[0068] g. Predictable: The built-in mathematical model can be used to predict the amount of postoperative astigmatism correction under this treatment plan.

[0069] The background section of the present invention may contain background information about the problem or environment of the present invention, but does not necessarily describe the prior art. Therefore, the content included in the background section is not an admission by the applicant that the prior art is available.

[0070] The above content is a further detailed description of the present invention in combination with specific / preferred embodiments, and it cannot be determined that the specific implementation of the present invention is limited to these descriptions. For ordinary technicians in the technical field to which the present invention belongs, without departing from the concept of the present invention, it can also make several substitutions or modifications to these described embodiments, and these substitutions or modifications should be regarded as belonging to the protection scope of the present invention. In the description of this specification, the description of the reference terms "an embodiment", "some embodiments", "preferred embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in combination with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily target the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In the absence of mutual contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples. Although the embodiments of the present invention and their advantages have been described in detail, it should be understood that various changes, substitutions and modifications can be made herein without departing from the scope of protection of the patent application.

Claims

1. A visual corneal cross-linking astigmatism correction system guided by corneal topography imaging, characterized in that: The invention comprises a cross-linking treatment module, a real-time detection module and a control module, wherein the cross-linking treatment module is used to output a light spot for realizing corneal cross-linking treatment, the real-time detection module is used to detect the eye morphology and corneal topography imaging during treatment in real time in synchronization with the cross-linking treatment, and dynamically locate the astigmatism treatment axis according to the corneal topography changes detected in real time, the control module generates a corneal cross-linking pattern scheme according to the corneal topography detected and imaged in real time by the real-time detection module and the dynamically located astigmatism treatment axis, and controls the cross-linking treatment module to output the light spot according to the corneal cross-linking pattern scheme, thereby realizing corneal cross-linking astigmatism correction guided by corneal topography imaging; wherein the cross-linking treatment module comprises an ultraviolet light source, the real-time detection module comprises a white light source, the control module controls the ultraviolet light source and the white light source to emit ultraviolet light and white light alternately in pulses, so that the cross-linking treatment and the real-time detection are performed alternately and synchronously; under the control of the control module, the white light source of the real-time detection module outputs the light spot in pulses. The invention relates to a placido ring image projection, wherein the placido ring image is a concentric ring image of alternating light and dark; the real-time detection module comprises an imaging unit and an image processing unit, wherein the imaging unit collects the placido ring image projection formed by the white light source, and the image processing unit analyzes the placido ring image projection in real time, selects the points where the placido ring image is projected on 360 semi-meridians, calculates the position change of each point by comparing the preset data in the database, performs spherical fitting, and calculates the relative height, radius of curvature and curvature of each cornea point compared with the standard spherical surface with a 240*240 dot matrix, and generates corneal topography, wherein the corneal topography comprises a corneal anterior surface height map and a corneal anterior surface tangential curvature map; wherein a cross-linking pattern is designed based on the corneal anterior surface height map, wherein a circular ring with a diameter of 4mm to 9mm and the pupil as the center is selected, and the area formed by each point within the circular ring whose relative height is greater than zero, that is, whose absolute height is higher than that of the standard eye, is defined as a cross-linking pattern.

2. The visualized corneal cross-linking astigmatism correction system according to claim 1, characterized in that: The imaging unit includes four cameras, which are respectively located at 12 o'clock, 3 o'clock, 6 o'clock and 9 o'clock above the eyeball and are used to capture the eye morphology and the placido ring image projection.

3. The visualized corneal cross-linking astigmatism correction system according to any one of claims 1 to 2, characterized in that: During cross-linking treatment, ultraviolet light is used to project a cross-linking pattern in a pulsed manner, with the cross-linking energy being 0-30 mW / cm2 and the oxygen concentration being greater than or equal to 95%. The cross-linking energy is determined based on the relative height range of the anterior surface of the cornea in the cross-linking area and the degree of corneal astigmatism. During real-time detection, white light is used to project a placido ring image in a pulsed manner, with the cross-linking energy being 1 second off and 1 second on.

4. The visualized corneal cross-linking astigmatism correction system according to claim 3, characterized in that: The cross-linking treatment module includes an oxygen supply unit, which includes an oxygen supply eye mask, an output pipeline, an oxygen generating device, and an oxygen concentration detection device, which is used to complete the continuous output of oxygen and real-time concentration detection during the treatment process, so that the oxygen concentration during the treatment process is greater than or equal to 95%.

5. The visualized corneal cross-linking astigmatism correction system according to any one of claims 1 to 2, characterized in that: The control module is a control storage module, and the control storage module also stores the eye morphology and corneal topography imaging changes recorded by the real-time detection module in the form of video and / or picture.

6. The visualized corneal cross-linking astigmatism correction system according to any one of claims 1 to 2, characterized in that: It also includes a display unit for displaying the eye morphology and corneal topography before, during and after treatment.

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