An automatic chemiluminescence immunoassay analyzer

Abstract

The present invention discloses a fully automatic chemiluminescence immunoassay analyzer, which relates to the technical field of fully automatic chemiluminescence immunoassay analyzers and includes: a sample management device; a sample buffer device; a line device; a reaction cup supply device; a reagent management device; a gripper device for grasping and transferring reaction cups and releasing the reaction cups when the reaction cups are moved in place; a mixing device for synchronously mixing the reaction cups during the process of transporting the reaction cups; a sample addition device; a reagent addition device; an incubation device for incubating the reaction cups containing reagent solution and sample solution; a cleaning and photometry device for performing cleaning and photometry operations on the reaction cups containing reagent solution and sample solution and automatically discarding the reaction cups; a washing device for washing the sample addition device and the reagent addition device; and a control device. This device can improve the testing efficiency of a single instrument and solve the problems of large floor area and small throughput of the instrument.

Description

Technical Field

[0001] The present invention relates to the technical field of fully automatic chemiluminescence immunoassay analyzers, and more specifically, to a fully automatic chemiluminescence immunoassay analyzer. Background Art

[0002] A fully automatic chemiluminescence immunoassay analyzer is an important tool in medical clinics. A fully automatic chemiluminescence immunoassay analyzer is provided with a reaction cup automatic supply module, a gripper module, an incubation module, a sample adding module, a cleaning module, etc. In general fully automatic chemiluminescence immunoassay, usually each module is placed on the frame in sequence and arranged in order, which severely restricts the detection speed of the instrument and affects the detection efficiency. High-speed instruments on the market generally require multiple instruments to be combined to achieve high-speed testing, which occupies a large area and cannot be placed in some places with limited space.

[0003] In summary, how to improve the testing efficiency of a single instrument to solve the problems of large floor area and small throughput of the instrument is an urgent problem to be solved by those skilled in the art at present. Summary of the Invention

[0004] In view of this, the purpose of the present invention is to provide a fully automatic chemiluminescence immunoassay analyzer to improve the testing efficiency of a single instrument to solve the problems of large floor area and small throughput of the instrument.

[0005] To achieve the above purpose, the present invention provides the following technical solutions:

[0006] A fully automatic chemiluminescence immunoassay analyzer, comprising:

[0007] A sample management device for placing and retrieving sample tubes;

[0008] A sample buffer device for temporarily storing sample tubes;

[0009] A line device for transporting sample tubes between various components;

[0010] A reaction cup supply device for providing reaction cups;

[0011] A reagent management device for placing reagent tubes;

[0012] A gripper device for grasping and transferring reaction cups and releasing the reaction cups when the reaction cups move into place;

[0013] A mixing device for synchronously mixing the reaction cups during the process of transporting the reaction cups;

[0014] A sample adding device for transferring the sample liquid in the sample tube into the reaction cup;

[0015] A reagent adding device for transferring the reagent liquid in the reagent tube into the reaction cup;

[0016] An incubation device for incubating reaction cups filled with reagent solution and sample solution;

[0017] A cleaning and photometric device for cleaning, photometrically measuring reaction cups filled with reagent solution and sample solution, and automatically discarding the reaction cups;

[0018] A washing device for washing the sample adding device and the reagent adding device;

[0019] A control device, to which the sample management device, the sample buffer device, the conveyor device, the reaction cup supply device, the reagent management device, the gripper device, the mixing device, the sample adding device, the incubation device, the cleaning and photometric device, and the cleaning device are all connected.

[0020] Preferably, the sample management device includes a sample injection area and a sample recovery area arranged side by side. The sample injection area is provided with a sample injection tray that can reciprocate and is used to load multiple sample racks, and a sample pusher that is used to push a single sample rack into the sample buffer device. The sample rack is used to place multiple sample tubes;

[0021] The sample recovery area is provided with a recovery tray that can reciprocate and is used to unload multiple sample racks, a sample hook that is used to hook a single sample rack back from the sample buffer device to the sample recovery area, and a quantity sensor. The quantity sensor is arranged at one end of the sample recovery area and is used to emit a prompt sound when the sample recovery area is full of sample racks.

[0022] Preferably, the sample buffer device is provided with a buffer area, a barcode scanner, a transfer trolley, and an emergency area. The buffer area is used to buffer the sample tubes to be tested. The sample tubes located in the emergency area have the priority for detection;

[0023] The barcode scanner is used to collect the barcode information of the sample tubes and upload the collected information to the control device. The transfer trolley is used to transport the sample racks from the emergency area or the buffer area to the conveyor device.

[0024] Preferably, the conveyor device includes a regular channel for transporting the sample racks in the buffer area, an emergency channel for transporting the sample racks in the emergency area, and a return channel for recycling the sample racks after the detection is completed;

[0025] A conventional pusher is provided in the conventional channel, an emergency pusher is provided in the emergency channel, and a return pusher is provided in the return channel. The conventional pusher, the emergency pusher and the return pusher are all used to control the sample rack to switch positions in the channel; a track change blocking device is provided between the conventional channel and the emergency channel, and between the conventional channel and the return channel, and the track change blocking device is used to achieve connectivity or isolation of adjacent channels.

[0026] Preferably, the reagent management device includes a reagent tray for accommodating multiple reagent tubes, a rotating device for driving the reagent tray to rotate circumferentially, a refrigeration device for providing a low-temperature environment for the reagent tubes, and an identification sensor for identifying the information barcodes of the reagent tubes. The rotating device, the refrigeration device and the identification sensor are all connected to the control device.

[0027] Preferably, the two mixing devices are respectively located on both sides of the diluting device, and the mixing device includes a mixing head for accommodating a reaction cup, a first moving device for driving the mixing head to move back and forth, and a first shaking device for driving the mixing head to shake, and the first moving device, the first shaking device and the diluting device are all connected to the control device;

[0028] The dilution device includes two dilution heads for accommodating reaction cups, a second moving device for driving the dilution heads to move back and forth, a second shaking device for driving the dilution heads to shake, and a liquid suction device for adding diluent to the dilution heads and sucking out the residual liquid after dilution.

[0029] Preferably, the number of the reagent adding devices is 2, which are distributed corresponding to the positions of the two mixing devices. The sample adding device is provided in the middle of the two mixing devices, and the sample adding device and the reagent adding device have the same structure.

[0030] The reagent adding device includes a liquid collection needle for absorbing or discharging liquid, a rotating part for driving the liquid collection needle to rotate circumferentially, a lifting part for driving the liquid collection needle to move up and down, and a cleaning part for flushing the outer periphery of the liquid collection needle.

[0031] Preferably, the washing device includes a vacuum system for providing negative pressure for cleaning the liquid collection needle, a concentration barrel for loading concentrated liquid, a purification barrel for loading purified water, a cleaning barrel for mixing the concentrated liquid and purified water, and a proportioning pump, the purification barrel and the concentration barrel are both connected to the input port of the proportioning pump, and the output port of the proportioning pump is connected to the cleaning liquid barrel.

[0032] Preferably, the reaction cup supply device includes a hopper, a slideway, and a display screen. The hopper is used to hold reaction cups. The slideway is a cache for reaction cups. The hopper is provided with a detection device for detecting the number of reaction cups. The display screen is used to emit corresponding prompt signals when the number of reaction cups is insufficient or excessive.

[0033] Preferably, the incubation device includes an incubation plate provided with a plurality of incubation holes for accommodating reaction cups, a reciprocating device for driving the incubation plate to reciprocate horizontally, and a heating device for providing the required temperature to the incubation holes. The plurality of incubation holes are arranged in a nested array.

[0034] Preferably, the number of the gripper devices is 3. The first gripper device is used to grab reaction cups from the reaction cup supply device and move the reaction cups to the mixing device;

[0035] The second gripper device is used to transfer the reaction cups after adding sample liquid and reagent liquid and being mixed from the mixing device to the incubation device or discard the reaction cups;

[0036] The third gripper device is used to transfer the reaction cups of the incubation device to the cleaning and photometry device, and transfer the reaction cups of the cleaning and photometry device in the multi-step method to the mixing device.

[0037] Preferably, the cleaning and photometry device includes a switch door, a switch motor for driving the opening and closing of the switch door, a moving turntable provided with a plurality of photometry slot seats for placing reaction cups, a rotating device for driving the rotation of the moving turntable, a liquid suction needle for sucking the liquid in the reaction cup, a first lifting device for driving the lifting movement of the liquid suction needle, a liquid injection needle for injecting the required liquid into the reaction cup, a second lifting device for driving the lifting movement of the liquid injection needle, a photometry element for testing the luminescence value of the reaction cup, and a waste part for recycling the discarded reaction cups. The moving turntable is of a disk spiral structure.

[0038] When using the fully automatic chemiluminescence immunoassay analyzer provided by the present invention, the samples to be tested can enter the analyzer through the sample management device, the sample buffer device, and the line body device. The gripper device can place a new reaction cup from the reaction cup supply device to the mixing position of the mixing device. Then, the mixing device transfers the empty reaction cup to the sample addition device for sample addition operation. After adding the sample, the mixing device transfers the reaction cup to the reagent addition device for reagent addition operation. The reaction cup after the addition operation can be mixed under the action of the mixing device. After mixing is completed, the gripper device can grab the reaction cup and place it in the incubation device for incubation. After the incubation operation is completed, the gripper device can grab the reaction cup in the incubation device and place it in the cleaning and photometry device for cleaning and photometry operation, and the reaction cup is automatically discarded after the photometry operation. Among them, the mixing device can operate the reagent addition position, the sample addition position, and the mixing position all by one device, effectively reducing the transfer time of the reaction cup, improving the detection efficiency of the instrument, and making the overall structure of the device more compact, solving the problem of large floor area of the instrument.

[0039] In summary, the fully automatic chemiluminescence immunoassay analyzer provided by the present invention improves the testing efficiency of a single instrument to solve the problems of large floor area and small throughput of the instrument. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only the embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained according to the provided drawings without creative efforts.

[0041] Figure 1 It is a schematic structural diagram of the fully automatic chemiluminescence immunoassay analyzer provided by the present invention;

[0042] Figure 2 It is a schematic structural diagram of the sample management device;

[0043] Figure 3 It is a schematic structural diagram of the sample buffer device;

[0044] Figure 4 It is the front view of the incubation device;

[0045] Figure 5 It is the top view of the incubation device;

[0046] Figure 6 It is the side view of the incubation device;

[0047] Figure 7 It is the front view of the mixing device;

[0048] Figure 8 is a side view of the mixing device;

[0049] Figure 9 This is the front view of the dilution device;

[0050] Figure 10 is a top view of the dilution device;

[0051] Figure 11 This is the main view of the reagent adding device;

[0052] Figure 12 A top view of the reagent adding device;

[0053] Figure 13 This is the main view of the reagent management device;

[0054] Figure 14 It is a bottom view of the reagent management device;

[0055] Figure 15 is a top view of the reagent management device;

[0056] Figure 16 This is a front view of the reaction cup supply device;

[0057] Figure 17 A top view of a reaction cup supply device;

[0058] Figure 18 This is a front view of the light metering device for cleaning;

[0059] Figure 19 A schematic diagram of the structure of the cleaning light measuring device;

[0060] Figure 20 A top view of the light metering device for cleaning;

[0061] Figure 21 This is an exploded view of the linear device;

[0062] Figure 22 It is a structural diagram of the gripper device;

[0063] Figure 23 Schematic diagram of the structure of the washing device.

[0064] Figures 1 - 23 middle:

[0065] 1 is a sample management device, 14 is a sample gripper, 15 is a return pusher, 16 is a recovery tray, 17 is a sample loading tray, 18 is a sample pusher, 19 is a transfer pusher, 2 is a sample buffer device, 21 is a buffer area, 22 is a barcode scanner, 23 is a transfer trolley, 24 is an emergency area, 3 is a conveyor device, 31 is a regular channel, 32 is an emergency channel, 33 is a return channel, 34 is a regular pusher, 35 is an emergency pusher, 36 is a return pusher, 37 is a track-changing blocking device, 4 is a reaction cup supply device, 41 is a hopper, 42 is a chute, 43 is a display screen, 44 is a high-level sensor, 45 is a low-level sensor, 5 is a reagent management device, 51 is a reagent tray, 52 is a rotating device, 521 is a large gear, 522 is a small gear, 523 is a transmission shaft, 524 is a driving synchronous pulley, 525 is a driving synchronous belt, 526 is a driving motor, 53 is a refrigeration device, 531 is a fan, 532 is a Peltier element, 533 is a refrigeration material part, 534 is a heat sink, 54 is an identification sensor, 6 is a gripper device, 61 is a horizontal motor, 62 is a vertical motor, 63 is a horizontal guide rail, 64 is a vertical guide rail, 7 is a mixing device, 71 is a mixing head, 72 is a first moving device, 73 is a first shaking device, 8 is a sample adding device, 9 is a reagent adding device, 91 is a liquid taking needle, 92 is a rotating part, 921 is a horizontal synchronous belt, 922 is a rotating motor, 93 is a lifting part, 931 is a vertical synchronous belt, 932 is an up-down motor, 94 is a cleaning part, 10 is an incubation device, 101 is an incubation tray, 102 is a reciprocating device, 11 is a cleaning and photometric device, 111 is a door, 112 is a door motor, 113 is a moving turntable, 114 is a rotating device, 115 is a liquid suction needle, 116 is a first lifting device, 117 is a liquid injection needle, 118 is a second lifting device, 119 is a photometric element, 1110 is a waste part, 1111 is a heating sheet, 1112 is a first suction needle, 1113 is a first suction lifting device, 1114 is a photometric mixing position, 1115 is a mixing gripper, 1116 is a photometric shielding motor, 1117 is a photometric groove seat, 12 is a washing device, 121 is a concentration barrel, 122 is a purification barrel, 123 is a cleaning barrel, 124 is a proportioning pump, 13 is a dilution device, 131 is a dilution head, 132 is a second moving device, 133 is a second shaking device, 134 is a liquid extraction device. Detailed implementation manners

[0066] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0067] The core of the present invention is to provide a fully automatic chemiluminescence immunoassay analyzer to improve the testing efficiency of a single instrument and solve the problems of large floor area and small throughput of the instrument.

[0068] Please refer to Figures 1 - 23 。

[0069] This specific embodiment provides a fully automatic chemiluminescence immunoassay analyzer, including:

[0070] A sample management device 1 for placing and retrieving sample tubes;

[0071] A sample buffer device 2 for temporarily storing sample tubes;

[0072] A conveyor device 3 for transporting sample tubes between various components;

[0073] A reaction cup supply device 4 for providing reaction cups;

[0074] A reagent management device 5 for placing reagent tubes;

[0075] A gripper device 6 for grasping and transferring reaction cups and releasing the reaction cups when they move into place;

[0076] A mixing device 7 for synchronously mixing the reaction cups during the transportation of the reaction cups;

[0077] A sample addition device 8 for transferring the sample liquid in the sample tube into the reaction cup;

[0078] A reagent addition device 9 for transferring the reagent liquid in the reagent tube into the reaction cup;

[0079] An incubation device 10 for incubating the reaction cups containing the reagent liquid and the sample liquid;

[0080] A cleaning and photometry device 11 for performing cleaning and photometry operations on the reaction cups containing the reagent liquid and the sample liquid and automatically discarding the reaction cups;

[0081] A washing device 12 for washing the sample addition device 8 and the reagent addition device 9;

[0082] A control device, the sample management device 1, the sample buffer device 2, the conveyor device 3, the reaction cup supply device 4, the reagent management device 5, the gripper device 6, the mixing device 7, the sample addition device 8, the incubation device 10, the cleaning and photometry device 11, and the cleaning device are all connected to the control device.

[0083] During the actual operation process, the shape, structure, dimensions, material, etc. of the sample management device 1, sample buffer device 2, conveyor device 3, reaction cup supply device 4, reagent management device 5, gripper device 6, mixing device 7, sample addition device 8, incubation device 10, cleaning and photometric measurement device 11, cleaning device, and control device can be determined according to the actual situation and actual requirements.

[0084] When using the fully automatic chemiluminescence immunoassay analyzer provided by the present invention, the samples to be tested can enter the analyzer through the sample management device 1, sample buffer device 2, and conveyor device 3. The gripper device 6 can place a new reaction cup from the reaction cup supply device 4 to the mixing position of the mixing device 7. Then, the mixing device 7 transfers the empty reaction cup to the sample addition device 8 for sample addition operation. After adding the sample, the mixing device 7 transfers the reaction cup to the reagent addition device 9 for reagent addition operation. The reaction cup after the addition operation can be mixed under the action of the mixing device 7. After mixing is completed, the gripper device 6 can grab the reaction cup and place it in the incubation device 10 for incubation. After the incubation operation is completed, the gripper device 6 can grab the reaction cup in the incubation device 10 and place it in the cleaning and photometric measurement device 11 for cleaning and photometric measurement operation, and the reaction cup is automatically discarded after the photometric measurement operation. Among them, the mixing device 7 can unify the reagent addition position, sample addition position, and mixing position to be operated by one device, effectively reducing the transfer time of the reaction cup, improving the detection efficiency of the instrument, and making the overall structure of the device more compact, solving the problem of large floor area of the instrument.

[0085] In summary, the fully automatic chemiluminescence immunoassay analyzer provided by the present invention improves the testing efficiency of a single instrument to solve the problems of large floor area and small throughput of the instrument.

[0086] On the basis of the above embodiments, preferably, the sample management device 1 includes a sample injection area and a recovery area distributed in parallel. The sample injection area is provided with a sample injection tray 17 that can reciprocate and is used to load multiple sample racks, and a sample pusher 18 that is used to push a single sample rack into the sample buffer device 2. The sample rack is used to place multiple sample tubes. The recovery area is provided with a recovery tray 16 that can reciprocate and is used to unload multiple sample racks, a sample hook 14 that is used to hook a single sample rack back from the sample buffer device 2 to the recovery area, and a quantity sensor. The quantity sensor is arranged at one end of the recovery area and is used to emit a prompt sound when the recovery area is full of sample racks.

[0087] It should be noted that the sample tray 17 can hold 30 sample racks at a time, and each sample rack can hold 5 sample tubes, which is equivalent to loading a maximum of 150 sample tubes to be tested at a time, thereby effectively improving the detection efficiency of the device. During use, multiple sample racks enter the sample feeding area through the sample tray 17, and are then pushed to the sample transfer area by the sample pusher 18. The sample racks are then moved to the scanning area of the sample buffer device 2 by the transfer pusher 19 to read the information of the sample tubes. Finally, the sample racks are transferred to the cache waiting position of the sample buffer device 2. The sample racks that have completed the test will also be transferred to the cache waiting position, and then transferred to the sample return area by the sample hook 14, and then enter the recovery area from the sample return area through the return pusher 15. Since a quantity sensor is provided at the other end of the recovery area, when the sample rack is pushed to the position of the quantity sensor and the quantity sensor is triggered, the quantity sensor can emit a prompt sound to indicate that the number of sample racks in the recovery area is full, reminding the operator to clean the sample racks. This device optimizes the instrument layout design to improve the test throughput of a single instrument without adopting a parallel solution, thereby solving the problem of small instrument footprint and high throughput.

[0088] Preferably, the sample buffer device 2 is provided with a buffer area 21, a barcode scanner 22, a transfer pulley 23 and an emergency area 24. The buffer area 21 is used to cache the sample tubes to be tested, and the sample tubes located in the emergency area 24 have priority detection rights; the barcode scanner 22 is used to collect the barcode information of the sample tubes and upload the collected information to the control device, and the transfer pulley 23 is used to transport the sample rack from the emergency area 24 or the buffer area 21 to the line device 3. The sample rack to be tested can enter the sample buffer device 2 through the corresponding channel, and then perform automatic barcode scanning, automatic information uploading and other operations. When there are a large number of samples to be tested, the sample tubes automatically enter the corresponding cache position in the buffer area 21. In addition, the sample tubes located in the emergency area 24 have priority detection rights and can be tested before the sample tubes in the buffer area 21.

[0089] Preferably, the line device 3 includes a conventional channel 31 for conveying sample racks in the buffer area 21, an emergency channel 32 for conveying sample racks in the emergency area 24, and a return channel 33 for recovering sample racks that have been tested; a conventional pusher 34 is provided in the conventional channel 31, an emergency pusher 35 is provided in the emergency channel 32, and a return pusher 36 is provided in the return channel 33. The conventional pusher 34, the emergency pusher 35 and the return pusher 36 are all used to control the sample rack to switch its position in the channel; a track change blocking device 37 is provided between the conventional channel 31 and the emergency channel 32, and between the conventional channel 31 and the return channel 33. The track change blocking device 37 is used to achieve connectivity or isolation between adjacent channels.

[0090] It should be noted that after the sample rack comes out of the sample caching device 2, it enters the regular channel 31. The regular pusher 34 controls the sample rack to switch positions between test tubes. When the detection items of all the sample tubes on the sample rack are completed, the regular pusher 34 retracts, allowing the sample rack to continue moving until it reaches the caching position of the track-changing blocking device 37. After that, the sample rack enters the track-changing area of the track-changing blocking device 37, and the track-changing blocking device 37 performs a track-changing action to send the sample rack to the return channel 33, realizing the return operation of the sample rack. Similarly, the above operations can be performed on the sample rack on the emergency channel 32.

[0091] Preferably, the reagent management device 5 includes a reagent tray 51 for accommodating a plurality of reagent tubes, a rotating device 52 for driving the reagent tray 51 to rotate circumferentially, a refrigeration device 53 for providing a low-temperature environment for the reagent tubes, and an identification sensor 54 for identifying the information barcodes of the reagent tubes. The rotating device 52, the refrigeration device 53, and the identification sensor 54 are all connected to the control device.

[0092] It should be noted that the rotating device 52 can be set as a large gear 521, a small gear 522, a transmission shaft 523, a driving synchronous pulley 524, a driving synchronous belt 525, and a driving motor 526, and the structure is as Figures 13 - 15 shown. By controlling the operation of the driving motor 526, the driving synchronous pulley 524 can be rotated, so as to drive the transmission shaft 523 to rotate through the driving synchronous belt 525. When the transmission shaft 523 rotates, it can drive the small gear 522 to rotate, and then drive the large gear 521 meshing with the small gear 522 to rotate. When the large gear 521 rotates, it can drive the reagent tray 51 to rotate circumferentially. The refrigeration device 53 can be set as a fan 531, a refrigeration sheet 532, a refrigeration material piece 533, and a heat sink 534 arranged in sequence from top to bottom, so as to improve the heat dissipation effect of the refrigeration device 53 and prevent the reagent from failing or becoming unstable due to excessive temperature.

[0093] Therefore, a plurality of reagent tubes can be placed in the reagent tray 51. The identification sensor 54 can perform barcode scanning on each reagent tube placed in the reagent tray 51 to obtain and record the relevant information of the reagent tube. Then, the control device can control the operation of the refrigeration device 53 to make the reagent tray 51 in the required low-temperature environment and ensure the reaction activity of the reagent. At the same time, the control device can control the operation of the rotating device 52 to make the reagent tubes arranged circumferentially at equal intervals rotate circumferentially, so as to facilitate the reagent addition device 9 to add the reagent liquid into the reaction cup.

[0094] Based on the above embodiments, preferably, the two mixing devices 7 are respectively located on both sides of the dilution device 13. The mixing device 7 includes a mixing head 71 for accommodating reaction cups, a first moving device 72 for driving the mixing head 71 to reciprocate, and a first shaking device 73 for driving the mixing head 71 to shake. The first moving device 72, the first shaking device 73, and the dilution device 13 are all connected to the control device; the dilution device 13 includes two dilution heads 131 for accommodating reaction cups, a second moving device 132 for driving the dilution heads 131 to reciprocate, a second shaking device 133 for driving the dilution heads 131 to shake, and a liquid pumping device 134 for adding diluent to the dilution heads 131 and sucking the residual liquid after dilution. The first moving device 72 and the second moving device 132 can both be set as synchronous belt drive structures.

[0095] It should be noted that two mixing devices 7 are provided. The first mixing device 7 and the second mixing device 7 are respectively arranged corresponding to two positions and are located on both sides of the dilution device 13. Among them, the mixing device 7 can not only move in the horizontal direction but also perform the mixing operation. The mixing device 7 can combine the reagent addition position and the sample addition position and can perform the mixing action, canceling the operation time of the gripper device 6 between the reagent addition position, the sample addition position, and the mixing position, effectively improving the instrument efficiency. Moreover, the two mixing devices 7 can work simultaneously to improve the work efficiency.

[0096] It should also be noted that the dilution device 13 is provided with two dilution heads 131 (dilution positions) with adjacent positions. The two dilution positions are distributed one in front of the other and can perform dilution and mixing actions separately or simultaneously. Moreover, the dilution device 13 can also move horizontally and perform the mixing operation. A waste liquid pumping device can be provided on one side of the dilution device 13 to handle the residual liquid after dilution.

[0097] It should be supplemented that when diluting the sample liquid, the cooperation process of the mixing device 7 and the dilution device 13 is as follows: The gripper device 6 grabs an empty reaction cup to the dilution position of the dilution device 13, and the dilution device 13 transfers the empty reaction cup to the sample addition position of the sample addition device 8 to add the sample liquid and perform dilution. While diluting the sample liquid, the gripper device 6 can grab an empty reaction cup to the mixing device #7, and the mixing device 7 transfers the empty reaction cup to the sample addition position of the sample addition device 8. The sample addition device 8 sucks the diluted sample liquid on the dilution device 13 into the reaction cup on the mixing device 7. Then, the mixing device 7 transfers the reaction cup to the reagent addition position of the reagent addition device 9 to facilitate the addition of reagents. The subsequent operations are the same as the normal experimental steps without diluting the sample liquid until the test is completed.

[0098] Preferably, the number of reagent adding devices 9 is 2, which are distributed corresponding to the positions of the two mixing devices 7. A sample adding device 8 is provided in the middle of the two mixing devices 7. The sample adding device 8 and the reagent adding device 9 have the same structure. The reagent adding device 9 includes a liquid taking needle 91 for sucking or discharging liquid, a rotating part 92 for driving the liquid taking needle 91 to rotate circumferentially, a lifting part 93 for driving the liquid taking needle 91 to move up and down, and a cleaning part 94 for flushing the outer periphery of the liquid taking needle 91.

[0099] It should be noted that the sample adding device 8 can realize both rotational motion and vertical motion. By adopting a fixed sample adding method, only rotational motion and vertical motion are required to realize the operations of sample liquid addition and dilution. Then, the liquid taking needle 91 can transfer the sample liquid or the diluted sample liquid to the reaction cups at the mixing positions of the mixing devices 7 and the dilution positions of the dilution device 13 to realize the sample liquid addition operation.

[0100] It should also be noted that the reagent adding device 9 can realize both rotational motion and vertical motion. By adopting a fixed reagent adding method, only rotational motion and vertical motion are required to realize the reagent liquid addition operation. Then, the liquid taking needle 91 can transfer the reagent or the substances required for the reaction to the reaction cups at the mixing positions of the mixing devices 7 and the dilution positions of the dilution device 13 to realize the reagent liquid addition operation. The reagent adding devices 9 are divided into two, which are distributed on the left and right respectively, corresponding to the first reagent management device 5 and the second reagent management device 5, corresponding to the first mixing device 7 and the second mixing device 7, and corresponding to the first dilution position and the second dilution position.

[0101] In addition, it should be noted that the rotating part 92 can be set as a horizontal synchronous belt 921 distributed in the horizontal direction and a rotating motor 922 for driving the horizontal synchronous belt 921 to rotate circumferentially. The lifting part 93 can be set as a vertical synchronous belt 931 distributed in the vertical direction and an up-and-down motor 932 for driving the vertical synchronous belt 931 to rotate circumferentially. The liquid taking needle 91 is vertically connected to a horizontally distributed connecting rod, the connecting rod is vertically connected to a vertical rod, a gear part is sleeved on the outer periphery of the vertical rod, and the gear part and the vertical rod are connected by a spline, and the two can rotate and move up and down synchronously. The horizontal synchronous belt 921 is wound around the outer periphery of the gear part. The gear part, the rotating motor 922 and the horizontal synchronous belt 921 are all arranged on a support plate. A vertical plate is vertically arranged below the support plate, a slide rail is arranged on the vertical plate, the vertical synchronous belt 931 and the up-and-down motor 932 are both arranged on the vertical plate, the vertical rod is connected to a slider on the vertical synchronous belt 931, and the slider is slidably connected to the slide rail. Therefore, under the driving action of the up-and-down motor 932, the vertical synchronous belt 931 rotates circumferentially, so that the slider slides up and down relative to the slide rail, and then the vertical rod drives the liquid taking needle 91 to move up and down.

[0102] Preferably, the washing device 12 includes a vacuum system for providing a cleaning negative pressure for the liquid taking needle 91, a concentrate barrel 121 for loading the concentrate, a purified water barrel 122 for loading purified water, a cleaning barrel 123 for mixing the concentrate and the purified water, and a proportioning pump 124. Both the purified water barrel 122 and the concentrate barrel 121 are communicated with the input port of the proportioning pump 124, and the output port of the proportioning pump 124 is communicated with the cleaning liquid barrel.

[0103] It should be noted that when it is necessary to wash the sample adding device 8 and the reagent adding device 9, the vacuum system can provide a cleaning negative pressure for the liquid taking needle 91. Moreover, the washing device 12 can automatically proportion the cleaning liquid to fully clean the inner and outer walls of the liquid taking needle 91 with the cleaning liquid. When there is less purified water in the instrument, the instrument can automatically fill water using the proportioning pump 124. When the cleaning liquid is insufficient, the washing device 12 can achieve automatic proportioning. Two series-connected cleaning barrels 123 can be provided. When performing the automatic proportioning operation, the purified water and the concentrate can be pumped into the first cleaning barrel 123 through the proportioning pump 124 for mixing. Then, the mixed cleaning liquid is pumped into the second cleaning barrel 123 for use in cleaning the instrument, which can also ensure that the automatic proportioning operation is more accurate.

[0104] Preferably, the reaction cup supply device 4 includes a hopper 41, a slideway 42, and a display screen 43. The hopper 41 is used to hold reaction cups. The slideway 42 is a cache for reaction cups. The hopper 41 is provided with a detection device for detecting the number of reaction cups. The display screen 43 is used to issue corresponding prompt signals when the number of reaction cups is insufficient or excessive.

[0105] It should be noted that the detection device includes a high-level sensor 44 provided at the high position of the hopper 41 and a low-level sensor 45 provided at the low position of the hopper 41. When the number of reaction cups in the hopper 41 is large and higher than the position of the high-level sensor 44, the high-level sensor 44 will be triggered, and the display screen 43 can issue a signal to stop adding reaction cups to the hopper 41. When the number of reaction cups in the hopper 41 is consumed greatly and lower than the position of the low-level sensor 45, the low-level sensor 45 will be triggered, and the display screen 43 can issue a signal to resume adding reaction cups to the hopper 41. That is, when the height of the reaction cups is between the low-level sensor 45 and the high-level sensor 44, there is no need to continuously add reaction cups to the hopper 41, so as to reduce the labor intensity of the operator.

[0106] On the basis of the above embodiments, preferably, the incubation device 10 includes an incubation plate 101 provided with a plurality of incubation holes for accommodating reaction cups, a reciprocating device 102 for driving the incubation plate 101 to reciprocate horizontally, and a heating device for providing the required temperature to the incubation holes. The plurality of incubation holes are distributed in a nested array.

[0107] It should be noted that the incubation wells are arranged in a nested array, which can effectively improve the space utilization rate of the instrument. Moreover, the incubation device 10 can move horizontally to facilitate the gripper device 6 to transfer the reaction cups. The incubation device 10 is an independent device that can accommodate no more than 340 test reaction cups and can incubate each reaction cup individually. Usually, after the reaction cups complete the mixing operation, the gripper device 6 can move the mixed reaction cups into the incubation wells of the incubation tray 101 for incubation.

[0108] Preferably, the number of gripper devices 6 is 3. The first gripper device 6 is used to pick up the reaction cups from the reaction cup supply device 4 and move the reaction cups to the mixing device 7;

[0109] The second gripper device 6 is used to transfer the reaction cups that have been added with the sample liquid and reagent liquid and mixed from the mixing device 7 to the incubation device 10 or discard the reaction cups;

[0110] The third gripper device 6 is used to transfer the reaction cups in the incubation device 10 to the cleaning and photometric device 11 and transfer the reaction cups in the cleaning and photometric device 11 in the multi-step method to the mixing device 7.

[0111] It should be noted that when using the analyzer of the present application, the sample tubes to be tested enter the analytical instrument through the sample management device 1, the sample buffer device 2, and the line device 3. The first gripper device 6 places the empty reaction cups from the reaction cup supply device 4 at the mixing position of the mixing device 7. Then, the mixing device 7 transfers the empty reaction cups to the sample addition position of the sample addition device 8 for sample addition operation. After adding the sample, the mixing device 7 transfers the reaction cups to the reagent addition position of the reagent addition device 9 for reagent addition operation. After completing the reagent addition operation, the mixing is performed in place. After mixing is completed, the reaction cups are transferred to the cup-gripping position of the second gripper device 6, and the gripper device 6 grabs the reaction cups and places them in the incubation device 10 for incubation. After the incubation operation is completed, the third gripper device 6 grabs the reaction cups in the incubation device 10 and places them in the cleaning and photometric device 11 for cleaning and photometric operation. After the photometric operation is completed, the reaction cups can be automatically discarded. The three gripper devices 6 cooperate with each other and independently complete the corresponding tests. When cleaning the reaction cups, the second and third gripper devices 6 alternate for cleaning, which can shorten the cleaning time of the reaction cups and reduce the labor intensity of the operators.

[0112] It should also be noted that the gripper device 6 can be connected to a horizontal motor61 for driving the horizontal movement of the gripper device 6 and can also be connected to a vertical motor 62 for driving the vertical movement of the gripper device 6. Moreover, the three gripper devices 6 can be arranged side by side on the same bracket, and a horizontal guide rail 63 and a vertical guide rail 64 are provided on the bracket to facilitate the horizontal movement or vertical movement of the gripper device 6 and make the device structure more compact.

[0113] Preferably, the cleaning and photometry device 11 includes a switch door 111, a switch motor 112 for driving the opening and closing of the switch door 111, a moving turntable 113 provided with a plurality of photometry trough seats 1117 for placing reaction cups, a rotating device 114 for driving the rotation of the moving turntable 113, a liquid suction needle 115 for sucking the liquid in the reaction cup, a first lifting device 116 for driving the lifting movement of the liquid suction needle 115, a liquid injection needle 117 for injecting the required liquid into the reaction cup, a second lifting device 118 for driving the lifting movement of the liquid injection needle 117, a photometry element 119 for testing the luminescence value of the reaction cup, and a waste part 1110 for recycling the discarded reaction cups. The moving turntable 113 is of a disc spiral structure.

[0114] It should be noted that after the incubation operation is completed, the gripper device 6 transports the incubated reaction cup to the cleaning and photometry device 11 for cleaning and photometry operations. After the photometry operation is completed, the reaction cup is automatically discarded into the waste part 1110. Since the moving turntable 113 is of a disc spiral structure, the reaction cup to be tested moves along the disc spiral track until it is discarded after the test is completed. The cleaning and photometry device 11 has the functions of cleaning, heat preservation, mixing, and photometry, and can automatically discard the reaction cup after the test is completed.

[0115] It should be further noted that the cleaning and photometry device l1 further includes a photometry mixing member for performing a rotation and mixing operation on the reaction cup and a heating sheet 1111 for providing the required temperature for the moving turntable 113. The usage process of the cleaning and photometry device 11 is as follows: the switch motor 112 opens the switch door 111 of the cleaning and photometry device 11, and then, the third gripper device 6 grabs the reaction cup from the incubation device 10 to the photometry trough seat 1117 of the cleaning and photometry device 11. After that, the third gripper device 6 lifts up and the switch motor 112 drives the switch door 111 to close.

[0116] The rotating device 114 can drive the moving turntable 113 to rotate through a belt pulley and a driving shaft, and then drive the reaction cup to rotate on the photometry trough seat 1117. When the reaction cup moves to the position of the first suction needle 1112, the first suction lifting device 1113 drives the first suction needle 1112 to descend to perform the first liquid suction operation on the reaction cup. Then, when the reaction cup continues to rotate below the liquid suction needle 115, the first lifting device 116 drives the liquid suction needle 115 to descend, and the liquid suction needle 115 sucks the remaining liquid in the reaction cup after the reaction is completed. After that, the first lifting device 116 drives the liquid suction needle 115 to rise back to the origin position. The reaction cup then moves to the liquid injection position, and the second lifting device 118 drives the liquid injection needle 117 to descend, and the liquid injection needle 117 can inject liquid into the reaction cup. After that, the second lifting device 118 drives the liquid injection needle 117 to rise back to the origin position.

[0117] Multiple liquid suction needles 115 and liquid injection needles 117 are arranged in sequence. During the rotation of the moving turntable 113, the reaction cup can be immediately moved to the liquid suction position. The first lifting device 116 drives the liquid suction needle 115 to descend to suck the liquid in the reaction cup. After five times of liquid suction and five times of liquid injection, the liquid in the reaction cup is basically cleaned, and only the part required for testing remains. Then, the reaction cup is transferred to the position of the mixing gripper 1115. The mixing gripper 1115 grabs the reaction cup to the photometric mixing position 1114. The photometric mixing position 1114 can perform a rotation mixing operation on the reaction cup. Then, the mixing gripper 1115 grabs the reaction cup with mixing completed back into the moving turntable 113. The reaction cup continues to rotate. When the reaction cup moves to the position of the photometric element 119, photometry starts. During photometry, the photometric shading motor 1116 drives the light shielding sheet to block the external light source to measure the luminescence value of the reaction cup. After the photometry operation is completed, the reaction cup moves to the waste position and is automatically discarded.

[0118] It should be noted that for the first lifting device 116 and the second lifting device 118 mentioned in this application document, the first and the second are only used to distinguish different positions and there is no order of precedence.

[0119] In addition, it should also be noted that the orientation or positional relationship indicated by "above", "below", etc. in this application is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of simplified description and understanding, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation to the present invention.

[0120] Each embodiment in this specification is described in a progressive manner. The key point of each embodiment is to illustrate the differences from other embodiments. The same or similar parts among the embodiments can be referred to each other. Any combination of all the embodiments provided by the present invention is within the protection scope of this invention and will not be elaborated here.

[0121] The above has introduced the fully automatic chemiluminescence immunoassay analyzer provided by the present invention in detail. Specific examples are used in this article to elaborate on the principle and implementation manner of the present invention. The description of the above embodiments is only used to help understand the method and its core idea of the present invention. It should be pointed out that for those of ordinary skill in the art in this technical field, without departing from the principle of the present invention, several improvements and modifications can still be made to the present invention, and these improvements and modifications also fall within the protection scope of the claims of the present invention.

Claims

1. An automatic chemiluminescence immunoassay analyzer, characterized in that, Including: A sample management device (1) for placing and retrieving sample tubes; A sample caching device (2) for temporarily storing sample tubes; A conveyor device (3) for transporting sample tubes between components; A reaction cup supply device (4) for providing reaction cups; A reagent management device (5) for placing reagent tubes; A gripper device (6) for grasping and transferring reaction cups and releasing the reaction cups when they are moved into place; A mixing device (7) for synchronously mixing reaction cups during the transportation of the reaction cups. Two of the mixing devices (7) are respectively located on both sides of a dilution device (13). The mixing device (7) includes a mixing head (71) for accommodating the reaction cups, a first moving device (72) for driving the mixing head (71) to reciprocate, and a first shaking device (73) for driving the mixing head (71) to shake. The first moving device (72), the first shaking device (73), and the dilution device (13) are all connected to a control device; the dilution device (13) includes two dilution heads (131) for accommodating the reaction cups, a second moving device (132) for driving the dilution heads (131) to reciprocate, a second shaking device (133) for driving the dilution heads (131) to shake, and a liquid pumping device (134) for adding diluent to the dilution heads (131) and sucking the residual liquid after dilution; A sample adding device (8) for transferring the sample liquid in the sample tube into the reaction cup; A reagent adding device (9) for transferring the reagent liquid in the reagent tube into the reaction cup; An incubation device (10) for incubating the reaction cups containing the reagent liquid and the sample liquid; A cleaning and photometric measurement device (11) for performing cleaning and photometric measurement operations on the reaction cups containing the reagent liquid and the sample liquid and automatically discarding the reaction cups; A washing device (12) for washing the sample adding device (8) and the reagent adding device (9); Among them, the number of the gripper devices (6) is 3. The first gripper device (6) is used to grasp the reaction cup from the reaction cup supply device (4) and move the reaction cup to the mixing device (7); the second gripper device (6) is used to transfer the reaction cup after adding the sample liquid and the reagent liquid and mixing it from the mixing device (7) to the incubation device (10) or discard the reaction cup; the third gripper device (6) is used to transfer the reaction cup of the incubation device (10) to the cleaning and photometric measurement device (11) and transfer the reaction cup of the cleaning and photometric measurement device (11) in the multi-step method to the mixing device (7); A control device, and the sample management device (1), the sample caching device (2), the conveyor device (3), the reaction cup supply device (4), the reagent management device (5), the gripper device (6), the mixing device (7), the sample adding device (8), the incubation device (10), the cleaning and photometric measurement device (11), and the washing device (12) are all connected to the control device.

2. The fully automatic chemiluminescence immunoassay analyzer according to claim 1, wherein, The sample management device (1) comprises a sample introduction area and a recovery area arranged in parallel, wherein the sample introduction area is provided with a sample introduction tray (17) that can be reciprocated and is used to load a plurality of sample racks, and a sample pusher (18) for pushing a single sample rack into the sample buffer device (2), wherein the sample rack is used to place a plurality of sample tubes; The recycling area is provided with a recycling tray (16) that can be reciprocated and is used to carry out multiple sample racks, a sample hook (14) for hooking a single sample rack from the sample buffer device (2) back to the recycling area, and a quantity sensor, wherein the quantity sensor is provided at one end of the recycling area and is used to emit a prompt sound when the recycling area is full of sample racks.

3. The fully automatic chemiluminescence immunoassay analyzer according to claim 1, wherein The sample caching device (2) is provided with a cache area (21), a barcode scanner (22), a transfer trolley (23), and an emergency area (24). The cache area (21) is used to cache sample tubes to be tested, and the sample tubes located in the emergency area (24) have priority for testing; The barcode scanner (22) is used to collect barcode information of the sample tube and upload the collected information to the control device, and the transfer pulley (23) is used to transport the sample rack from the emergency area (24) or the buffer area (21) to the line device (3).

4. The fully automatic chemiluminescence immunoassay analyzer according to claim 3, wherein The line device (3) includes a conventional channel (31) for transporting sample racks in the buffer area (21), an emergency channel (32) for transporting sample racks in the emergency area (24), and a return channel (33) for recovering sample racks that have completed testing; A conventional pusher (34) is provided in the conventional channel (31), an emergency pusher (35) is provided in the emergency channel (32), and a return pusher (36) is provided in the return channel (33). The conventional pusher (34), the emergency pusher (35) and the return pusher (36) are all used to control the sample rack to switch positions in the channel; a track-changing blocking device (37) is provided between the conventional channel (31) and the emergency channel (32), and between the conventional channel (31) and the return channel (33). The track-changing blocking device (37) is used to achieve the connection or isolation of adjacent channels.

5. The fully automatic chemiluminescence immunoassay analyzer according to claim 1, wherein, The reagent management device (5) comprises a reagent tray (51) for accommodating a plurality of reagent tubes, a rotating device (52) for driving the reagent tray (51) to rotate circumferentially, a refrigeration device (53) for providing a low-temperature environment for the reagent tubes, and an identification sensor (54) for identifying information bar codes of the reagent tubes. The rotating device (52), the refrigeration device (53), and the identification sensor (54) are all connected to the control device.

6. The fully automatic chemiluminescence immunoassay analyzer according to any one of claims 1 to 5, characterized in that, The number of the reagent adding devices (9) is 2, and they are distributed corresponding to the positions of the two mixing devices (7). The sample adding device (8) is provided in the middle of the two mixing devices (7). The sample adding device (8) and the reagent adding device (9) have the same structure. The reagent adding device (9) includes a liquid taking needle (91) for sucking or discharging liquid, a rotating part (92) for driving the circumferential rotation of the liquid taking needle (91), a lifting part (93) for driving the up and down movement of the liquid taking needle (91), and a cleaning part (94) for flushing the outer peripheral part of the liquid taking needle (91).

7. The fully automatic chemiluminescence immunoassay analyzer according to claim 6, wherein, The washing device (12) includes a vacuum system for providing the cleaning negative pressure of the liquid taking needle (91), a concentrate barrel (121) for loading the concentrate, a purified water barrel (122) for loading the purified water, a cleaning barrel (123) for mixing the concentrate and the purified water, and a proportioning pump (124). The purified water barrel (122) and the concentrate barrel (121) are both communicated with the input port of the proportioning pump (124), and the output port of the proportioning pump (124) is communicated with the cleaning barrel (123).

8. The fully automatic chemiluminescence immunoassay analyzer according to any one of claims 1 to 5, characterized in that, The reaction cup supply device (4) includes a hopper (41), a slideway (42), and a display screen (43). The hopper (41) is used for holding reaction cups. The slideway (42) is a cache for reaction cups. The hopper (41) is provided with a detection device for detecting the number of reaction cups. The display screen (43) is used for sending out corresponding prompt signals when the number of reaction cups is insufficient or excessive.

9. The fully automatic chemiluminescence immunoassay analyzer according to any one of claims 1 to 5, characterized in that The incubation device (10) includes an incubation plate (101) provided with a plurality of incubation holes for accommodating reaction cups, a reciprocating device (102) for driving the incubation plate (101) to reciprocate horizontally, and a heating device for providing the required temperature to the incubation holes. The plurality of incubation holes are distributed in a nested array.

10. The fully automatic chemiluminescence immunoassay analyzer according to any one of claims 1 to 5, characterized in that, The cleaning and photometric device (11) includes a switch door (111), a switch motor (112) for driving the opening and closing of the switch door (111), a moving turntable (113) provided with a plurality of photometric groove seats (1117) for placing reaction cups, a rotating device (114) for driving the rotation of the moving turntable (ll3), a liquid suction needle (115) for sucking the liquid in the reaction cup, a first lifting device (116) for driving the up and down movement of the liquid suction needle (115), a liquid injection needle (117) for injecting the required liquid into the reaction cup, a second lifting device (118) for driving the up and down movement of the liquid injection needle (117), a photometric element (119) for testing the luminescence value of the reaction cup, and a waste part (1110) for recycling the waste reaction cups. The moving turntable (113) is of a disc spiral structure.

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