Automatic injector device for delivering a medicament

Abstract

An automatic injector device for delivering a medicament is disclosed. The automatic injector device includes a syringe assembly having a needle adapted to expel the medicament from the syringe assembly and a barrel adapted to hold the medicament. The syringe assembly includes a plunger coaxially positioned relative to the barrel and adapted to reciprocate within the barrel to expel the medicament from the barrel. Further, the syringe assembly includes a locking member adapted to engage the plunger to hold the plunger in position relative to the barrel. The position of the plunger relative to the barrel is adapted to be adjusted to vary the volume of medicament to be expelled from the barrel. The position of the plunger is adjusted by engaging the locking member with the plunger at one of a plurality of positions along the length of the plunger.

Description

Technical Field

[0001] This invention relates to a drug delivery device, and more particularly to an auto-injector device for delivering drugs. Background Technology

[0002] With technological advancements, various injection devices (such as manual injection devices and autoinjector devices) are used to administer medications for applications in fields such as medicine, therapy, diagnostics, pharmaceuticals, and cosmetics. Users and healthcare professionals now increasingly prefer autoinjector devices for medication administration. A key reason for this shift is the significantly reduced training required to use autoinjector devices.

[0003] Typically, autoinjector devices comprise a pre-filled syringe or cartridge containing a specific volume of medication to be delivered to the user. The volume of medication filled in the autoinjector device depends on various parameters, such as the type of medication and the user's medical condition. Currently, autoinjector devices can only be configured to carry a specific volume of medication, and configurations for changing the medication volume without altering the construction or operational characteristics of the various sub-components of the autoinjector device are not available.

[0004] Therefore, this could lead to a significant reduction in the overall reusability of autoinjector devices for administering different types and doses of drugs. Furthermore, the type and dose of the drug to be administered may become a design constraint on the manufacture of the autoinjector device. For example, sub-components of the autoinjector device may need to be manufactured based on the type of drug and the corresponding dose of that drug to be administered via the autoinjector device. This could lead to a significant increase in the overall manufacturing cost of the autoinjector device. Summary of the Invention

[0005] This summary is provided to introduce, in a simplified format, some concepts that will be further described in the detailed description of the invention. This summary is not intended to identify key or fundamental inventive concepts of the invention, nor is it intended to define the scope of the invention.

[0006] In one embodiment of the invention, an autoinjector device for delivering a drug is disclosed. The autoinjector device includes a syringe assembly having a needle adapted to dispensing a drug from the syringe assembly. The syringe assembly includes a barrel adapted to hold the drug and coupled to the needle. The drug flow is guided out of the barrel through the needle. The syringe assembly includes a plunger coaxially positioned relative to the barrel and adapted to reciprocate within the barrel to dispensing the drug. Further, the syringe assembly includes a locking member adapted to engage the plunger to hold the plunger in place relative to the barrel. The position of the plunger relative to the barrel is adapted to be adjusted to change the volume of drug to be dispensed from the barrel. The position of the plunger is adjusted by engaging the locking member with the plunger at one of a plurality of positions along the length of the plunger.

[0007] To further illustrate the advantages and features of the invention, a more specific description of the invention will be presented with reference to specific embodiments illustrated in the accompanying drawings. It should be understood that these drawings depict only typical embodiments of the invention and should not be considered as limiting the scope of the invention. The invention will be described and explained with additional features and details in conjunction with the accompanying drawings. Attached Figure Description

[0008] These and other features, aspects, and advantages of the invention will become better understood when the following detailed description is read with reference to the accompanying drawings, in which the same reference numerals denote the same parts throughout the drawings.

[0009] Figure 1 An auto-injector device according to an embodiment of the present invention and steps involved in an embodiment of an auto-injector device for delivering drugs are illustrated;

[0010] Figure 2a A perspective view of an auto-injector device according to an embodiment of the present invention is shown;

[0011] Figure 2b An exploded view of an auto-injector device according to an embodiment of the present invention is shown;

[0012] Figure 3a and Figure 3b A cross-sectional view of an auto-injector device according to an embodiment of the present invention is shown;

[0013] Figure 4 A perspective view of the plunger of an auto-injector device according to an embodiment of the present invention is shown;

[0014] Figures 5a to 5c The operation of an auto-injector device for delivering drugs according to an embodiment of the present invention is illustrated; and

[0015] Figure 6 Examples of embodiments according to the present invention, such as Figure 5c An enlarged sectional view of part A of the auto-injector device shown.

[0016] Furthermore, those skilled in the art should understand that the elements in the accompanying drawings are illustrative for simplicity and may not necessarily be drawn to scale. For example, flowcharts illustrate methods according to the most prominent steps involved to aid in understanding various aspects of the invention. Moreover, regarding the construction of the apparatus, one or more components of the apparatus may have already been represented by conventional symbols in the drawings, and the drawings may only show those specific details relevant to understanding embodiments of the invention, so as not to obscure the drawings with details that would be readily apparent to those skilled in the art who would benefit from the description herein. Detailed Implementation

[0017] To facilitate understanding of the principles of the invention, reference will now be made to the embodiments illustrated in the accompanying drawings, and these embodiments will be described using specific language. However, it should be understood that this is not intended to limit the scope of the invention, and such changes and further modifications in the illustrated systems, as well as such further applications of the principles of the invention illustrated therein, are considered to be commonly conceived by those skilled in the art. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The systems, methods, and examples provided herein are illustrative only and not intended to be limiting.

[0018] As used herein, the term "some" is defined as "none, one, more than one, or all". Therefore, the terms "none", "one", "more than one", "more than one but not all", or "all" all fall under the definition of "some". The term "some embodiments" can refer to no embodiments, one embodiment, several embodiments, or all embodiments. Therefore, the term "some embodiments" is defined as meaning "no embodiments, one embodiment, more than one embodiment, or all embodiments".

[0019] The terminology and structure used herein are intended to describe, teach, and illustrate certain embodiments and their specific features and elements, and are not intended to limit, constrain, or reduce the spirit and scope of the claims or their equivalents.

[0020] More specifically, any terms used herein, such as, but not limited to, “including,” “contains,” “having,” “comprising,” and their grammatical variations, do not prescribe precise limitations or constraints, and certainly do not preclude the addition of one or more features or elements unless otherwise stated, nor do they preclude the removal of one or more listed features and elements unless otherwise stated in the restrictive language “must include” or “requires inclusion.”

[0021] Whether or not a feature or element is limited to use only once, it may still be referred to as "one or more features," "one or more elements," "at least one feature," or "at least one element." Furthermore, the use of the terms "one or more" or "at least one" features or elements does not preclude the absence of that feature or element unless otherwise specified by restrictive language such as "one or more..." or "one or more elements are required."

[0022] Unless otherwise defined, all terms used herein, especially any technical and / or scientific terms, shall be considered to have the same meaning as commonly understood by one of ordinary skill in the art.

[0023] Reference is made to several “exemplary embodiments” herein. It should be understood that embodiments are examples of possible implementations of any feature and / or element presented in the appended claims. Several embodiments have been described to illustrate one or more potential ways in which specific features and / or elements of the appended claims satisfy the requirements of uniqueness, utility, and non-obviousness.

[0024] The use of phrases and / or terms (e.g., but not limited to "first embodiment," "another embodiment," "alternative embodiment," "one embodiment," "embodiment," "multiple embodiments," "some embodiments," "other embodiments," "additional embodiments," "further embodiments," "extra embodiments," or variations thereof) does not necessarily refer to the same embodiment. Unless otherwise specified, one or more specific features and / or elements described in connection with one or more embodiments may be found in one embodiment, or in more than one embodiment, or in all embodiments, or may not be found in any embodiment. Although one or more features and / or elements are described herein only in the context of a single embodiment, or alternatively in the context of more than one embodiment, or further alternatively in the context of all embodiments, such features and / or elements may alternatively be provided individually or in any suitable combination or not at all. Conversely, any features and / or elements described in the context of a single embodiment may alternatively be implemented as being present together in the context of a single embodiment.

[0025] Any and all details set forth herein are used in the context of some embodiments and should therefore not be considered as limiting factors of the appended claims. The appended claims and their legal equivalents may be implemented in the context of embodiments other than those described below as illustrative examples.

[0026] Embodiments of the present invention will now be described in more detail with reference to the accompanying drawings.

[0027] Figure 1 An autoinjector device 100 according to an embodiment of the present invention and steps involved in an embodiment of the autoinjector device 100 for delivering medication are illustrated. In one embodiment, the autoinjector device 100 can be used to deliver medication (interchangeably referred to as a drug) to a patient. The autoinjector device 100 may include a proximal end 102 and a distal end 104. Further, the autoinjector device 100 may include a cap 106 removably attached to the distal end 104 of the autoinjector device 100. The cap 106 may be configured to protect the needle of the autoinjector device 100 and limit any contaminants from entering the autoinjector device 100.

[0028] In order to implement the automatic injector device 100 for drug administration, refer to Figure 1In step 108, the cap 106 of the autoinjector device 100 can be removed to deliver medication to the patient. Then, in step 110, the distal end 104 of the autoinjector device 100 can be placed on the patient at an injection site corresponding to the subcutaneous (sub-Q) area to deliver medication. After placing the autoinjector device 100 on the site, it can be pressed towards the injection site and held for a predetermined period of time to deliver medication to the patient through the site. Then, in step 112, the autoinjector device 100 can be removed from the injection site and disposed of in a sharps collector.

[0029] The construction and operation details of the auto-injector device 100 are explained in detail in the following sections of the invention.

[0030] Figure 2a A perspective view of an auto-injector device according to an embodiment of the present invention is shown. Figure 2b An exploded view of an auto-injector device 100 according to an embodiment of the present invention is shown. Figure 3a and Figure 3b A cross-sectional view of an auto-injector device 100 according to an embodiment of the present invention is shown. (See reference...) Figure 2a , Figure 2b and Figure 3a In one embodiment, the autoinjector device 100 may include a first body member 202 and a second body member 204. The first body member 202 and the second body member 204 may be adapted to be coupled to each other to define a housing 205 for accommodating various sub-components of the autoinjector device 100. In one embodiment, the first body member 202 and the second body member 204 may be coupled to each other by a spring lock without departing from the scope of the invention.

[0031] Further, the autoinjector device 100 may include a syringe assembly 206, a prefilled syringe (PFS) holder 208, a needle protector 210, a needle protector spring 212, a locking member 214, a plunger 216, a plunger spring 218, and a spring release arm 220. In one embodiment, the syringe assembly 206 may include, but is not limited to, a needle 222 and a barrel 224 adapted to be coupled to the needle 222. The barrel 224 may be adapted to hold medication. The barrel 224 may include a front portion and a rear portion away from the front portion. The front portion may be adapted to be coupled to the needle 222, and the rear portion may be adapted to movably receive the plunger 216.

[0032] Furthermore, the needle 222 may be adapted to dispense medication from the syringe assembly 206. The needle 222 may be adapted to be coupled to the front of the cartridge 224 such that during operation of the autoinjector device 100, a flow of medication may be guided through the needle 222 out of the cartridge 224. Furthermore, the PFS retainer 208 may be adapted to retain the syringe assembly 206 within the housing 205 of the autoinjector device 100.

[0033] In one embodiment, the needle protector 210 may be adapted to house the PFS retainer 208 together with the syringe assembly 206 within the autoinjector device 100. The needle protector 210 may include a proximal end 210-1 and a distal end 210-2. Further, a needle protector spring 212 may be adapted to be coupled to the needle protector 210. The needle protector spring 212 may be configured to allow the needle protector 210 to resiliently move in a direction along the axis X-X' of the autoinjector device 100 during operation of the autoinjector device 100.

[0034] Further, the spring release arm 220 can be positioned at the proximal end 102 of the autoinjector device 100. In one embodiment, the spring release arm 220 can be adapted to be coupled to the second body member 204. The spring release arm 220 can be adapted to support the plunger 216 and plunger spring 218 within the autoinjector device 100. The plunger 216 can be coaxially positioned relative to the barrel 224. The plunger 216 can be adapted to reciprocate within the barrel 224 to expel and draw medication into the barrel 224. The plunger 216 can be adapted to move along the axis X-X' of the autoinjector device 100. The plunger 216 can be adapted to reciprocate within the barrel 224 of the syringe assembly 206 to expel medication from the syringe assembly 206 and draw medication into the barrel 224.

[0035] Furthermore, the plunger spring 218 may be configured to allow the plunger 216 to move elastically within the cylinder 224 in a direction along the axis X-X'. Specifically, during operation of the autoinjector device 100, the plunger spring 218 may be adapted to elastically push the plunger 216 within the cylinder 224 to expel medication from the cylinder 224 of the syringe assembly 206. The plunger spring 218 may be adapted to be compressed between the head of the plunger 216 and the locking member 214.

[0036] Figure 4A perspective view of the plunger 216 of an auto-injector device 100 according to an embodiment of the present invention is shown. In one embodiment, a locking member 214 may be adapted to engage the plunger 216 to hold the plunger in place relative to the cylinder 224. Further, the locking member 214 may be adapted to hold the spring-release arm 220 in a locked position to ensure engagement of the spring-release arm 220 with the plunger 216. In one embodiment, the locking member 214 may be adapted to restrict at least a portion of the spring-release arm 220 to eliminate radially outward deflection of the spring-release arm 220 relative to the plunger 216, thereby ensuring engagement of the spring-release arm 220 with the plunger 216.

[0037] refer to Figure 3a , Figure 3b and Figure 4 The plunger 216 may include an engagement portion 402 extending along the length L of the plunger 216. In one embodiment, the engagement portion 402 may be implemented as either a helical groove or a circular groove without departing from the scope of the invention. A locking member 214 may be adapted to engage with the engagement portion 402 of the plunger 216 to retain the plunger 216 in a proper position within the autoinjector device 100. In particular, the locking member 214 may engage at one of a plurality of locations in the engagement portion 402 along the length L of the plunger 216.

[0038] The position of plunger 216 relative to cylinder 224 can be adapted to be adjusted to change the volume of drug to be discharged from cylinder 224. The position of plunger 216 can be adjusted by engaging locking member 214 with plunger 216 at one of a plurality of positions along the length L of plunger 216. In one embodiment, locking member 214 may include locking teeth 302 adapted to engage with engagement portion 402 of plunger 216. Locking member 214 may be operable between an engaged position and a disengaged position.

[0039] In one embodiment, the needle protector 210 may be adapted to move the locking member 214 from an engaged position to a disengaged position. In the engaged position, the locking teeth 302 may engage with the engagement portion 402 to hold the plunger 216 in a position remote from the distal end 104 of the autoinjector device 100. In this position, the plunger spring 218 may be compressed between the head of the plunger 216 and the locking member 214. Further, in the disengaged position, the needle protector 210 may move the locking member 214 toward the proximal end 102 of the autoinjector device 100. Due to this movement of the locking member 214, the locking teeth 302 may disengage from the engagement portion 402 of the plunger 216. Subsequently, the plunger spring 218 may push the plunger 216 toward the distal end 104 of the autoinjector device 100 within the cylinder 224 to expel medication from the syringe assembly 206.

[0040] As previously described, the position of the plunger 216 relative to the cylinder 224 within the autoinjector device 100 can be adjustable to deliver different volumes of medication from the autoinjector device 100. (Reference) Figure 3b and Figure 4 In one case, the locking member 214 may engage with the engagement portion 402 at a distance X1 relative to the length L of the plunger 216. In this case, the plunger 216 may be held at position P1 relative to the front portion 210-1 of the barrel 224 within the autoinjector device 100.

[0041] Due to this position of the plunger 216, the cartridge 224 can hold a volume V1 (i.e., the maximum volume) of medication for dispensing via the needle 222 during operation of the autoinjector device 100. Alternatively, the locking member 214 can engage with the engagement portion 402 at a distance X2 relative to the length L of the plunger 216. In this case, the plunger 216 can be held at position P2 relative to the front portion 210-1 of the cartridge 224 within the autoinjector device 100. Due to this position of the plunger 216, the cartridge 224 can hold a volume V2 of medication for dispensing via the needle 222.

[0042] Although the operation of the plunger 216 and locking member 214 in the illustrated embodiments is explained relative to positions P1 and P2 of the plunger 216 within the autoinjector device 100, as those skilled in the art will understand, the plunger 216 can be locked in multiple positions by the locking member 214 to change the volume of medication delivered from the autoinjector device 100 as needed without departing from the scope of the invention.

[0043] Figures 5a to 5c The operation of an auto-injector device 100 for delivering drugs according to an embodiment of the present invention is illustrated. Figure 6 Examples of embodiments according to the present invention, such as Figure 5c An enlarged cross-sectional view of part A of the autoinjector device 100 shown. First, in order to deliver medication to the subcutaneous area of ​​a patient via the autoinjector device 100, the cap 106 can be removed from the distal end 104 of the autoinjector device 100 to expose the needle 222 of the syringe assembly 206.

[0044] Further, refer to Figure 5bThe distal end 104 of the autoinjector device 100 can be placed on an injection site (i.e., skin) corresponding to the subcutaneous region of the patient. In one embodiment, the injection site can be selected based on various parameters (e.g., medical prescription, drug type, and volume of drug to be injected) without departing from the scope of the invention. The autoinjector device 100 can then be pressed against the skin such that the needle guard 210 is pressed against the skin, causing the needle guard 210 to move in a direction toward the proximal end 102 of the autoinjector device 100. Due to this movement of the needle guard 210, the needle 222 can be inserted into the subcutaneous region of the patient to deliver the drug. Further, after the drug is injected, the autoinjector device 100 can be removed from the skin, causing the needle guard 210 to move to cover the needle 222 of the autoinjector device 100. This largely eliminates potential injury that may occur due to the exposed needle when the autoinjector device 100 is withdrawn from the injection site.

[0045] refer to Figure 5c and Figure 6 Movement of the needle protector 210 can push the locking member 214 toward the proximal end 102 of the autoinjector device 100. This movement of the locking member 214 can cause the locking teeth 302 to disengage from the engagement 402 of the plunger 216. Specifically, the locking teeth 302 can move laterally away from the engagement 402, thereby unlocking the movement of the plunger 216 under the elastic force of the plunger spring 218. Subsequently, the plunger 216 can move within the cylinder 224 toward the distal end 104 of the autoinjector device 100 under the elastic force of the plunger spring 218. The plunger 216 can push the medication held within the cylinder 224 to deliver the medication to the patient's subcutaneous area through the needle 222 of the syringe assembly 206. In one embodiment, a rubber stopper (not shown) can be attached to the plunger 216 and adapted to move together with the plunger 216 within the cylinder 224 to expel the medication held within the cylinder 224 of the syringe assembly 206. The rubber stopper is adapted to be inserted into the cartridge 224 in such a way that the rubber stopper can act as a sealing member to prevent the medicine from flowing out of one end of the cartridge 224. The rubber stopper can move together with the plunger 216 to expel the medicine from the cartridge 224 through the needle 222 positioned at the other end of the cartridge 224.

[0046] As will be summarized, the autoinjector device 100 of the present invention includes a locking member 214 adapted to lock a plunger 216 in different positions to administer different volumes of medication via the autoinjector device 100. The plunger 216 may include an engagement portion 402 extending along a length L of the plunger 216. The locking member 214 may engage with the engagement portion 402 to hold the plunger 216 in a pre-loaded position to expel medication from the syringe assembly 206. The locking member 214 may engage with the engagement portion 402 at different positions along the length L of the plunger 216 to change the volume of medication to be administered via the autoinjector device 100.

[0047] Therefore, the autoinjector device 100 can be reused for different types and doses of drugs without incorporating any changes to the sub-components of the autoinjector device 100. In particular, this eliminates the need to manufacture different sub-components for the autoinjector device 100 for administering different types and doses of drugs. Furthermore, this substantially eliminates the overall manufacturing cost of the autoinjector device 100. Thus, the autoinjector device 100 of the present invention is flexible, compact, cost-effective, convenient in its implementation, and has a wide range of applications.

[0048] The autoinjector device 100 described herein can be used to deliver various therapeutic compounds, such as pharmaceuticals and biologics, including but not limited to antibodies, antisense substances, RNA interference substances, gene therapy substances, primitive and embryonic stem cells, vaccines, and combinations thereof. For example, the embodiments described herein can be used in combination with known monoclonal antibodies, including but not limited to: abciximab, arbiturumab, alilumab, actosulumab, adalimumab, adelimumab, adunumab, afacurumab, afimomab, afutuzumab, pego-arasizumab, ALD518, ALD403, alemtuzumab, amorombumab, pentiazem, amituzumab, amituzumab, AMG. 334. Other related terms include: Maranamozab, Rastar-Anettozab, Anilurozab, Anluzumab, Apozizumab, Asimozizumab, Avasuzumab, Aserizumab, Atezolizumab, Atenuzumab, Atetolizumab, Atrolimumab, Averuzumab, Bapizumab, Baliximab, Baviximab, Betomozab, Begolozab, Belimumab, Benazizumab, Betemuzumab, Bezozab, Bevacizumab, Belottosumab, Bisimab, Bimaluzumab, Bimegizumab, Mobivaruzumab, Bleruzumab, Bonatuzumab. Anti-, brontovelumab, buxojuzumab, bercoxetine, brecurumab, verbentuximab, brenumab, berdaruzumab, buxojuzumab, brontovelumab, buxojuzumab, carbiolizumab, canatumab, mocantozumab, rapantozumab, carpatizumab, pendimethalin calcimeroxumab, castrevir, calcimeroxumab, calcimeroxumab, caputuzumab, cBR96-doxorubicin immunoconjugate, cilizumab, interleukin-2 cerutuzumab, pecelizumab, cetuximab, pocitrazumab, cetuximab Monoclonal antibodies, clazazumab, crixacillin, Titan-clazatuzumab, cotrastuzumab, Lexon-cotrastuzumab, konamumab, comycillin, CR6261, clazatuzumab, crotonumab, dacizumab, dacrotozumab, pego-dapirizumab, daratumumab, detrickulumab, densizumab, martin-dinantuzumab, denosumab, martin-dituxizumab, bidotuzumab, demutuzumab, denutoxicum, dilivomarab, domalozumab, atorvastatin, traziltozumab Monoclonal antibodies, duligotumumab, dupilumab, durvalumab, dustautumab, emexizumab, icurizumab, ebazumab, efazolinumab, effenguumab, ediluzumab, edentolumab, erlotinib, erlotinib, erlotinib, esimoumab, emetinib, emetinib, emetinib, enastatin, vetin-enfretuzumab, peemmoumab, enotozumab, enoxacumab, enoxacumab, enoxacumab, enoxacumab, enoxacumab, enoxacumab, enoxacumab, enoxacumab, enoxacumab, enoxacumab, enoxacumab, emetinib, epetuzumab, errenoumab, erlizumabIdazumab, Itrarib, Ivesuzumab, Evolomumab, Avirazumab, Fasomumab, Faramolumab, Fatozumab, Fasinumab, FBTA05, Panvezzizumab, Fizanuzumab, Fibrituzumab, Filatuzumab, Fentuximab, Fentuximab, Flavutuzumab, Flantozumab, Flantozumab, Flavutuzumab, Forlanumab, Forlanumab Vimumab, fenimumab, forlanumab, vortoxicumab, ganezumab, galilixicumab, ganitinumab, ganitinumab, gavimumab, gejuzumab, gejuzumab, gejuzumab, vesin-glentoxicumab, golimumab, golimumab, gusecuzumab, ibazumab, teimumab, erucumab, edasarizumab, egosaizumab, egosaizumab Votumumab, IMA-638, IMAB362, Imarumab, Incemarab, Imedvirumab, Imatrozumab, P-selectin antagonist, Reintoxicum, Indutoxicum, Innerolizumab, Inflixicum, Enoximumab, Osintuzumab, Intolimumab, Ipilimumab, Itolimumab, Isatuxicum, Ilizumab, Ixetizumab, Keliximumab, Labetizumab, Pembrolizumab, Lanparibizumab, Lanalizumab, Lanrozumab, Encin-Lartuximab, LBR-101 / PF0442g7429, Levozumab, Lemasomumab, Lendalizumab, Lenzruzumab, Loratadine, Lesamumab, Rivirumab, Vitin-Lifatoxicum, Rigomery Monoclonal antibodies, sartamin-lilottozumab, lintozumab, lirelurumb, lodicilzumab, logivir, mocin-lovotozumab, rukamumab, pego-rulizumab, rucizumab, rutozumab, LY2951742, mapamumab, magtoxici, masmomumab, mastozumab, mefulimumab, mesoprazole ... Talcum, Milazumab, Minermab, Socin-Mituximab, Mitomumab, Moglicilil, Monalil, Moromomumab, Movizumab, Pakramumab, Moromomumab-CD3, Tanacomab, Namerumab, Eto-Naptomumab, Encin-Nattoximab, Nanattoximab, Natralumab, Nasrazizumab, Navir Vomumab, Nebacuzumab, Nexitozumab, Nemolizumab, Neremozumab, Nevasumab, Nitozumab, Nivolumab, Nofetozumab, Otosacuzumab, Obinutuzumab, Ocalutuzumab, Olejuzumab, Odumozumab, Ofamozumab, Olazumab, Olozumab, Omaluzumab, Ontoxitozumab, Opinuzumab, Motojuzumab, Ogovomumab, Otetuzumab, Oxytozumab, Olejuzumab, Oxytozumab, Oxytozumab, Ozanezumab, Olijuzumab, Paxizumab, Palizumab, Panerizumab, Pankomab, Pabacuzumab, Pasatuzumab, Pacozumab, Pertuximab, PertuximabPertratuzumab, Pembrolizumab, Petumumab, Pekracillin, Pertuzumab, Pexacillin, Pildizumab, Vitin-Pinatuzumab, Pintomorab, Pramuprolab, Lozalizumab, Pergalil, Verbotozumab, Ponatriuretic, Prezalizumab, Priliximab, Retoxacillin, Prilimumab, PRO 140. Quinolizumab, Raltomumab, Ratratuzumab, Ravizumab, Rapamiluzumab, Ramucirumab, Ralcizumab, Raxicurumab, Refanailuzumab, Regaviruzumab, Reticuzumab, Rituximab, Linusuzumab, Rexazumab, Rituximab, Pego-Rivarobazine, Rotozumab, Roledozumab, Romozumab, Longlizumab, Terslin-Lovazumab, Lovezumab, Lulizumab, Gossazumab, Shamazine, Sapizumab, Saliruzumab, Satozumab Motumab, pendimethalin, secukinumab, seretumab, sertoxaximab, seveximab, SGN-CD19A, SGN-CD33A, siroizumab, cifamumab, secukinumab, simutuzumab, cilizumab, silukumab, vetin-sofituzumab, sulanzumab, soritolumab, Sonepcizumab, succinate, staunchumab, thioxolumab, suveximab, taberucimab, titanate. Tetraxetan, Tadalafil, Talizumab, Tantovelumab, Tadalafil, Pertamozumab, Taretovelumab, Tetulomab, Tetulomab, Tetulomab, TGN1412, Tesimemumab, Tegafil, Tetrajumab, Tetulomab, Vitin-Tesoxetine, TNX-650, Tocilizumab, Tolizumab, Tosatosulam, Tosimo, Tovitumab, Trastuzumab, Trastuzumab-Metalafil conjugate, TRBS07, Tralizumab, Trastuzumab Memoxicillin, trogolumab, interleukin-2-tocotocillin, tuovirumab, utuoxicillin, uroluru, uroluru, utuzumab, utuzumab, utsenoside, utuoxicillin, taribrine-varadutuzumab, vetin-vantocillin, vantocillin, vanucal, vararixicillin, vararixicillin, vararixicillin, vetocillin, vepamocillin, vesenoside, vexicillin, voloxicillin, martin-vosertocillin, votocillin, zentocillin, zalumumab, zatumumab, zatocillin, zatuximab, ziramumab, azomocillin, or combinations thereof.

[0049] While specific language has been used to describe the subject matter, it is not intended to impose any limitation. It will be apparent to those skilled in the art that various working modifications can be made to the method to implement the inventive concepts taught herein. The accompanying drawings and the foregoing description provide examples of embodiments. Those skilled in the art will understand that one or more of the described elements can be well combined into a single functional element. Alternatively, certain elements may be divided into multiple functional elements. Elements from one embodiment may be added to another embodiment.

Claims

1. An automatic injector device (100), comprising: Syringe assembly (206), comprising: Needle (222), adapted to dispense medication from the syringe assembly (206); and A tube (224) adapted to hold the drug and connected to the needle (222), wherein the drug flow is guided out of the tube (224) through the needle (222). A plunger (216) is coaxially positioned relative to the cylinder (224) and adapted to reciprocate within the cylinder (224) to expel the drug; A locking member (214) adapted to engage with the plunger (216) to hold the plunger in place relative to the cylinder (224); and A needle protector (210) adapted to cover the needle tip and move the locking member (214) from an engaged position to a disengaged position, wherein the needle protector is spaced apart from the locking member, and wherein the needle protector engages the locking member in the disengaged position. The position of the plunger (216) relative to the cylinder (224) is adapted to be adjusted to change the volume of drug to be discharged from the cylinder (224), and the position of the plunger (216) is adjusted by engaging the locking member (214) with the plunger (216) at one of a plurality of positions along the length (L) of the plunger (216).

2. The automatic injector device (100) according to claim 1, characterized in that, It also includes a first body member (202) and a second body member (204), wherein the first body member (202) and the second body member (204) are adapted to be connected to each other to define a housing (205) therein.

3. The automatic injector device (100) according to claim 2, characterized in that, It also includes a prefilled syringe (PFS) holder (208) adapted to hold the syringe assembly (206) within the housing (205).

4. The auto-injector device (100) according to claim 1, characterized in that, The plunger (216) includes an engagement (402) extending along the length (L) of the plunger (216), wherein the locking member (214) engages at one of the plurality of locations in the engagement (402) along the length (L).

5. The auto-injector device (100) according to claim 4, characterized in that, It also includes a spring release arm (220) positioned at the proximal end (102) of the autoinjector device (100) and adapted to support the plunger (216) and the plunger spring (218).

6. The auto-injector device (100) according to claim 5, characterized in that, The locking member (214) includes a locking tooth (302) adapted to engage with the engagement portion (402) of the plunger (216), wherein the locking member (214) is adapted to hold the spring release arm (220) in a locked position to ensure engagement of the spring release arm (220) with the plunger (216).

7. The auto-injector device (100) according to claim 1, characterized in that, It also includes a needle protector spring (212) adapted to be coupled to the needle protector (210), wherein the needle protector spring (212) is adapted to allow elastic movement of the needle protector (210).

8. The auto-injector device (100) according to claim 6, characterized in that, In the engaged position, the locking teeth (302) of the locking member engage with the engagement portion (402) of the plunger to hold the plunger (216) in a position away from the distal end (104) of the auto-injector device (100); and In the disengaged position, the needle guard (210) moves the locking member (214) toward the proximal end (102) of the autoinjector device (100) to disengage the locking tooth (302) from the engagement (402).

9. The automatic injector device (100) according to claim 1, characterized in that, Also includes: A plunger spring (218) is adapted to be compressed between the head of the plunger (216) and the locking member (214), wherein the plunger spring (218) is adapted to elastically push the plunger (216) within the cylinder (224) to discharge the drug from the cylinder (224).

Images