Non-invasive drug injection system, control method, control device, apparatus and medium

Abstract

The embodiment of the application discloses a non-invasive drug injection system, a control method, a control device, equipment and a medium. The system comprises a control module, a non-invasive injection device and a pulse module; the pulse module comprises a pulse generator and a non-invasive pulse electrode sheet; the number of the non-invasive pulse electrode sheets comprises at least two; wherein the control module is connected with the non-invasive injection device and the pulse module respectively, and is used for issuing control instructions to the non-invasive injection device and the pulse module; the pulse generator is used for applying an electric field pulse to the injection area through the non-invasive pulse electrode sheet, and the electric field pulse is used for forming an injection channel in the injection area; and the non-invasive injection device is used for injecting a target drug into a preset injection position through the injection channel. The technical scheme disclosed in the embodiment of the application improves the safety and controllability of transdermal administration.

Description

Technical Field

[0001] The embodiments of the present invention relate to the field of intelligent medical technology, and in particular to a non-invasive drug injection system, control method, control device, equipment and medium. Background Technology

[0002] With the development of biotechnology, biological agents mainly composed of molecules such as peptides and proteins are becoming increasingly common. However, when taken orally, these biological agents are easily degraded in the liver and gastrointestinal tract, reducing their bioavailability. For a long time, electroporation delivery technology has not been effective in promoting transdermal drug delivery. However, existing electroporation techniques require both the injection needle and electrode needle to be inserted into the skin, causing significant tissue trauma and considerable fear and pain to the recipient. Summary of the Invention

[0003] This invention provides a non-invasive drug injection system, control method, control device, equipment, and medium, which improves the safety and controllability of transdermal drug delivery.

[0004] In a first aspect, embodiments of the present invention provide a non-invasive drug injection system, comprising: a control module, a non-invasive injection device, and a pulse module; the pulse module includes a pulse generator and non-invasive pulse electrode pads; the number of non-invasive pulse electrode pads includes at least two; the pulse generator is connected to each non-invasive pulse electrode pad via connecting lines, and the non-invasive pulse electrode pads are in contact with the surface of the injection area; wherein...

[0005] The control module is connected to the non-invasive injection device and the pulse module respectively, and is used to issue control commands to the non-invasive injection device and the pulse module;

[0006] The pulse generator is used to apply an electric field pulse to the injection area through a non-invasive pulse electrode, and the electric field pulse is used to form an injection channel in the injection area.

[0007] The non-invasive injection device is used to inject the target drug into a preset injection position through the injection channel.

[0008] Optionally, the non-invasive injection device injects the target drug into a preset injection site using a high-pressure jet method.

[0009] Optionally, the system further includes: at least one gripper; wherein,

[0010] Each clamp includes at least two clamps for clamping the surface of the injection area to bulge the injection area;

[0011] The at least two non-invasive pulse electrode pads are disposed on both sides of the raised injection area, such that the two non-invasive pulse electrode pads disposed on the surface of any injection area are disposed in opposite directions, and the two non-invasive pulse electrode pads are at a preset angle, wherein the preset angle is less than 180 degrees.

[0012] Optionally, the system further includes: a support module; wherein the support module includes a support frame and a support base;

[0013] The support frame is connected to the non-invasive injection device and the clamp respectively, and is used to position the non-invasive injection device and the clamp in a preset position.

[0014] Optionally, the system further includes: a power supply module; wherein,

[0015] The power module is connected to the control module, the non-invasive injection device, and the pulse module respectively, and is used to provide power to the control module, the non-invasive injection device, and the pulse module.

[0016] Optionally, the system further includes: a display device;

[0017] The display device is connected to the control module and is used to acquire injection parameters and display the injection status of the target drug.

[0018] Secondly, embodiments of the present invention provide a non-invasive drug injection control method, the method comprising:

[0019] The gripper's chuck is controlled to clamp the surface of the injection area, causing the injection area to bulge.

[0020] Two non-invasive pulse electrode pads are respectively positioned on both sides of the raised injection area, wherein the two non-invasive pulse electrode pads are positioned in opposite directions and are at a preset angle, wherein the preset angle is less than 180 degrees.

[0021] The injection parameters are obtained, and the non-invasive injection device and pulse module are controlled based on the injection parameters.

[0022] Thirdly, embodiments of the present invention also provide a non-invasive drug injection control device, the device comprising:

[0023] The gripper control module is used to control the gripper's chuck to grip the surface of the injection area, so as to make the injection area bulge.

[0024] The non-invasive pulse electrode control module is used to control two non-invasive pulse electrodes to be respectively placed on both sides of the raised injection area, wherein the two non-invasive pulse electrodes are placed in opposite directions and there is a preset angle between the two non-invasive pulse electrodes, wherein the preset angle is less than 180 degrees.

[0025] An injection module is used to control the non-invasive injection device and the pulse module based on the injection parameters.

[0026] Fourthly, embodiments of the present invention also provide an electronic device, the electronic device comprising:

[0027] One or more processors;

[0028] Storage device for storing one or more programs.

[0029] When the one or more programs are executed by the one or more processors, the one or more processors implement the non-invasive drug injection control method provided in any embodiment of the present invention.

[0030] Fifthly, embodiments of the present invention also provide a computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the non-invasive drug injection control method provided in any embodiment of the present invention.

[0031] The non-invasive drug injection system provided in this embodiment of the invention specifically includes: a control module, a non-invasive injection device, and a pulse module; the pulse module includes a pulse generator and non-invasive pulse electrode pads; the number of non-invasive pulse electrode pads includes at least two; the pulse generator is connected to each non-invasive pulse electrode pad via connecting lines, and the non-invasive pulse electrode pads are in contact with the surface of the injection area; wherein, the control module is connected to the non-invasive injection device and the pulse module respectively, and is used to issue control commands to the non-invasive injection device and the pulse module; the pulse generator is used to apply an electric field pulse to the injection area through the non-invasive pulse electrode pads, and the electric field pulse is used to form an injection channel in the injection area; the non-invasive injection device is used to inject the target drug into a preset injection position through the injection channel. The technical solution provided in this embodiment of the invention, by setting up a non-invasive injection device and non-invasive pulse electrode pads, avoids significant tissue trauma and improves the safety and controllability of transdermal drug delivery. Attached Figure Description

[0032] To more clearly illustrate the technical solutions of exemplary embodiments of the present invention, the accompanying drawings used in describing the embodiments are briefly introduced below. Obviously, the accompanying drawings described are only a portion of the drawings of the embodiments to be described in this invention, and not all of the drawings. For those skilled in the art, other drawings can be obtained from these drawings without any creative effort.

[0033] Figure 1 This is a schematic diagram of the non-invasive drug injection system provided in Embodiment 1 of the present invention;

[0034] Figure 2 This is a schematic diagram of the placement of the non-invasive pulse electrode pad according to Embodiment 1 of the present invention;

[0035] Figure 3 This is a schematic diagram of another non-invasive pulse electrode placement structure according to Embodiment 1 of the present invention;

[0036] Figure 4 This is a schematic diagram of another non-invasive pulse electrode placement structure according to Embodiment 1 of the present invention;

[0037] Figure 5 This is a flowchart illustrating the non-invasive drug injection control method provided in Embodiment 2 of the present invention;

[0038] Figure 6 This is a schematic diagram of the non-invasive drug injection control device provided in Embodiment 3 of the present invention;

[0039] Figure 7 This is a schematic diagram of the structure of the electronic device provided in Embodiment 4 of the present invention. Detailed Implementation

[0040] The present invention will now be described in further detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and not intended to limit it. Furthermore, it should be noted that, for ease of description, the accompanying drawings show only the parts relevant to the present invention, and not all of the structures.

[0041] Example 1

[0042] Figure 1 This is a schematic diagram of a non-invasive drug injection system provided in Embodiment 1 of the present invention. This embodiment is applicable to situations involving drug injection, and more specifically, to situations involving transdermal injection of molecular drugs.

[0043] Before introducing the technical solutions of the embodiments of the present invention, the application scenarios of the present invention will be described exemplarily: With the development of biotechnology, more and more types of biological agents have been developed for drug administration. However, when biological agents are taken orally, they are easily degraded in the liver and gastrointestinal tract, reducing bioavailability. Furthermore, administering biological agents with ordinary syringes can leave trauma at the injection site and cause fear in the recipient. In addition, to enable faster drug absorption, pulse signals are applied to the injection area to form a pulsed electric field, so that the cells in the injection area are in an electroporation state, which is conducive to drug penetration. However, existing pulsed electrode needles need to be inserted into the skin of the injection area, causing trauma and other uncontrollable problems to the injection site of the recipient.

[0044] To address the aforementioned technical problems, the non-invasive drug injection system provided in this embodiment of the invention reduces the fear of the recipient by providing a non-invasive syringe, and avoids trauma by applying a pulsed electric field using non-invasive pulsed electrode pads, thereby improving the safety and controllability of transdermal drug delivery.

[0045] like Figure 1 As shown, the system specifically includes: a control module 110, a non-invasive injection device 120, and a pulse module 130; the pulse module 130 includes a pulse generator 131 and non-invasive pulse electrode pads 132; the number of non-invasive pulse electrode pads 132 includes at least two; the pulse generator 131 is connected to each non-invasive pulse electrode pad 132 via connecting lines, and the non-invasive pulse electrode pads 132 are in contact with the surface of the injection area 140; wherein,

[0046] The control module 110 is connected to the non-invasive injection device 120 and the pulse module 130 respectively, and is used to issue control commands to the non-invasive injection device 120 and the pulse module 130.

[0047] The pulse generator 131 is used to apply an electric field pulse to the injection area 140 through the non-invasive pulse electrode 132, and the electric field pulse is used to form an injection channel in the injection area 140.

[0048] The non-invasive injection device 120 is used to inject the target drug into a preset injection position through the injection channel.

[0049] It is understood that the non-invasive electrode pad is used to transmit the pulse signal emitted by the pulse generator 131 to the skin surface of the injection area 140. Therefore, preferably, the non-invasive electrode pad can include a low-impedance electrode pad, such as an electrode pad with good conductivity like a conductive carbon film. Of course, to avoid discomfort caused by sensitivity in the injection area 140, the non-invasive electrode pad can also be a non-woven fabric electrode patch or other types of adhesive electrode pads. This embodiment does not limit this. The pulse generator 131 is used to provide pulse signals in this embodiment, so the model of the pulse generator 131 is not limited in this embodiment; it can simply emit pulse signals.

[0050] Specifically, in this embodiment, the controller is connected to the pulse generator 131 to generate a signal and issue a command based on the input signal parameters, which is then sent to the pulse signal generator. The pulse signal generator is electrically connected to at least one or two non-invasive pulse electrode pads 132 via connecting lines to send pulse signals to the non-invasive pulse electrode pads 132. The number of non-invasive electrode pads is even, and two non-invasive electrode pads form a group to form a pulsed electric field. The waveform of the pulse signal can include any waveform such as a sine wave, square wave, or triangular wave. This embodiment does not limit the waveform or signal size of the pulse signal; that is, the applied pulse signal can form a pulsed electric field. The non-invasive pulse electrode pads 132 are in contact with the surface of the injection area 140. Specifically, the non-invasive electrode pads can be applied to the surface of the injection area 140 so that the pulse signal transmitted to the non-invasive electrode pads forms a pulsed electric field through the skin. This pulsed electric field is used to form an injection channel within the injection area 140. The injection area 140 can be any skin area of ​​the injection target, such as a human or an animal. For example, the injection area 140 can be the left upper arm of a human or the back of an animal such as a mouse. This embodiment does not limit the location or target of the injection area 140.

[0051] In this embodiment, the non-invasive injection device 120 includes a non-invasive syringe 121 and a syringe holder 122. The syringe holder 122 is used to stabilize the syringe. The injection needle of the non-invasive syringe 121 may include an elliptical device with a dispensing orifice. This injection needle is used to inject medication at the injection site. The non-invasive syringe 121 is equipped with a pressurizing device to increase the internal pressure, thereby achieving high-pressure jet injection of the target drug to a preset injection location.

[0052] Specifically, the non-invasive injection device 120 is connected to a controller and, upon receiving an injection command from the controller, increases the pressure within the device using a pressurization device to inject the target drug via a high-pressure jet. The target drug includes, but is not limited to, molecular biological agents, such as polypeptides, proteins, oligonucleotides, and other molecular gene drugs.

[0053] The non-invasive drug injection system provided in this embodiment of the invention specifically includes: a control module 110, a non-invasive injection device 120, and a pulse module 130; the pulse module 130 includes a pulse generator 131 and non-invasive pulse electrode pads 132; the number of non-invasive pulse electrode pads 132 includes at least two; the pulse generator 131 is connected to each non-invasive pulse electrode pad 132 via connecting lines, and the non-invasive pulse electrode pads 132 are in contact with the surface of the injection area 140; wherein, the control module 110 is connected to the non-invasive injection device 120 and the pulse module 130 respectively, and is used to issue control commands to the non-invasive injection device 120 and the pulse module 130; the pulse generator 131 is used to apply an electric field pulse to the injection area 140 through the non-invasive pulse electrode pads 132, and the electric field pulse is used to form an injection channel in the injection area 140; the non-invasive injection device 120 is used to inject the target drug into a preset injection position through the injection channel. The technical solution provided in this embodiment of the invention avoids significant tissue trauma by setting up a non-invasive injection device 120 and a non-invasive pulse electrode 132, thereby improving the safety and controllability of transdermal drug delivery.

[0054] Based on the above embodiments, the non-invasive injection system provided by the present invention further includes: at least one clamp 150; wherein, any clamp 150 includes at least two clamps 151 for clamping the surface of the injection area 140 to make the injection area 140 bulge; the at least two non-invasive pulse electrode pads 132 are disposed on both sides of the bulging injection area 140, such that the two non-invasive pulse electrode pads 132 disposed in contact with the surface of any injection area 140 are disposed in opposite directions, and the two non-invasive pulse electrode pads form a preset angle, wherein the preset angle is less than 180 degrees.

[0055] In this embodiment of the invention, the non-invasive drug injection system includes at least one gripper 150 for raising the surface of the injection area 140. The number of grippers 150 may be one or more.

[0056] Optionally, when there is only one clamp 150, the clamp 150 includes at least two clamps 151. For ease of explanation, this embodiment uses a clamp 150 with two clamps 151 as an example: the connection points between the two clamps 151 and the clamp 150 are movable to facilitate gripping the surface of the injection site. The two clamps 151 are positioned at two endpoints within the injection area 140. When the control module issues a clamping command to the clamp 150, the two clamps 151 clamp the surface of the injection area 140, making the surface of the injection area 140 raised, so as to facilitate the placement of the non-invasive pulse electrode 132 on the raised surface of the injection area 140. Specifically, when the surface of the injection area 140 is raised, the non-invasive pulse electrode 132 is positioned on both sides of the raised surface of the injection area 140. A specific placement diagram is shown below. Figure 2 As shown: Two non-invasive pulse electrode pads 132 disposed on the surface of the injection area 140 are attached to the underside of the clamp 151, with the two non-invasive pulse electrode pads 132 facing each other and forming a preset angle between them, wherein the preset angle is less than 180 degrees. In some embodiments, if the clamping force applied by the clamp 150 to the injection site is different in strength and magnitude, the angle between the two non-invasive pulse electrode pads 132 will be different; for example, the control module 110 can control the clamp 150 to apply a clamping force of preset magnitude and direction, so that the two non-invasive pulse electrode pads 132 are in a parallel state, thereby forming a pulsed electric field more quickly. Of course, in this embodiment, the angle between the two non-invasive pulse electrode pads 132 can also be set to other angles such as less than 120 degrees or less than 90 degrees, depending on the actual situation, and this embodiment does not limit this.

[0057] Optionally, when there are multiple clamps 150, each clamp 150 includes at least two clamps 151. For ease of explanation, this embodiment uses a system with two clamps 150, each clamp including two clamps 151, as an example. In this system, the two clamps 150 respectively clamp the farthest endpoints within the injection area 140, causing the surface of the injection area 140 to bulge. The non-invasive pulse electrode, applied to the bulging surface of the injection area 140, is then placed between the two clamps 150. To more clearly illustrate the technical solution of this embodiment, a side view of the injection area 140 is used as an example. Figure 3 The illustration is shown below.

[0058] It should be noted that, in this embodiment, the two non-invasive pulse electrode pads 132 can be placed on the underside of the clamp 151, with the two non-invasive pulse electrode pads 132 facing each other and forming a preset angle between them, wherein the preset angle is less than 180 degrees, as described above. Figure 2The placement position shown is optional; alternatively, the two non-invasive pulse electrode pads 132 can also be placed on the inside of the clamp 151, with the two non-invasive pulse electrode pads 132 facing each other and forming a preset angle between them, wherein the preset angle is less than 180 degrees, i.e., as shown. Figure 4 The placement shown is to reduce the contact area with the injection site surface, while also ensuring the stability of the non-invasive pulse electrode 132's adhesion to the injection site surface. Of course, the positional relationship between the non-invasive pulse electrode 132 and the clamp 151 described above is only an optional embodiment; specific settings can be made according to actual circumstances, and this embodiment does not impose any limitations on this.

[0059] Based on the above embodiments, the non-invasive injection system provided in this embodiment of the invention further includes: a support module 160 and a power module 170; wherein, the support module 160 includes a support frame 161 and a support base 162; the support frame 161 is connected to the non-invasive injection device 120 and the clamp 150 respectively, for positioning the non-invasive injection device 120 and the clamp 150 in a preset position to facilitate drug injection at the injection site. The power module 170 is used to provide power to the control module 110, the non-invasive injection device 120 and the pulse module 130.

[0060] In some embodiments of the invention, the non-invasive drug injection system further includes a display device 180, which is connected to the control module 110 and is used to acquire injection parameters and display the injection status of the target drug. The injection parameters may include, but are not limited to, the dosage of the injected drug, the output waveform information of the pulse generator, and pulse signal information. The injection status of the target drug may include whether the target drug has been injected.

[0061] Specifically, before non-invasive drug injection, the injection parameters input or selected by the user can be acquired and transmitted to the control module 110. The control module 110 generates an injection command and a pulse signal output command based on the received injection parameters, and sends the injection command and pulse signal output command to the non-invasive injection device 120 and the pulse module 130, respectively. At this time, the target drug status is displayed as uninjected. When the control module 110 controls the non-invasive injection device 120 to execute the injection command, that is, when the target drug is being injected, the injection volume of the target drug can be displayed. After the target drug injection is completed, the display device 180 displays the target drug status as completed injection and the completed injection volume. Of course, the display device 180 can also acquire other data and display other information, which is not limited in this embodiment.

[0062] The following are embodiments of the non-invasive drug injection control method provided by the present invention. This non-invasive drug injection control method and the non-invasive drug injection system of the above embodiments belong to the same inventive concept. For details not described in detail in the embodiments of the non-invasive drug injection control method, please refer to the embodiments of the above non-invasive drug injection system.

[0063] Example 2

[0064] Figure 5 This is a flowchart illustrating a non-invasive drug injection control method according to Embodiment 2 of the present invention. This method can be executed by a non-invasive drug injection system, which can be implemented in software and / or hardware. Explanations of terms that are the same as or corresponding to those in the above embodiments are not repeated here. See also... Figure 5 The non-invasive drug injection control method provided in this embodiment includes:

[0065] S210. Control the clamps of the gripper to clamp the surface of the injection area so that the injection area bulges.

[0066] S220. Two non-invasive pulse electrode pads are respectively positioned on both sides of the raised injection area, wherein the two non-invasive pulse electrode pads are positioned in opposite directions and form a preset angle between them, wherein the preset angle is less than 180 degrees.

[0067] S230. Obtain injection parameters and control the non-invasive injection device and pulse module based on the injection parameters.

[0068] The non-invasive drug injection control method provided in this embodiment specifically includes: clamping the surface of the injection area by controlling the gripper to raise the injection area, facilitating the placement of the non-invasive pulse electrode pad on the raised injection area; further, controlling two non-invasive pulse electrode pads to be respectively positioned on both sides of the raised injection area, wherein the two non-invasive pulse electrode pads are positioned opposite each other and form a preset angle between them, wherein the preset angle is less than 180 degrees, so that the pulse rapidly applied by the pulse generator forms a pulsed electric field to quickly open the injection channel; acquiring injection parameters, and controlling the non-invasive injection device and pulse module to inject the target drug into the injection area based on the injection parameters. The technical solution provided by this embodiment of the invention, by controlling the gripper to raise the skin, makes the placement of the non-invasive electrode pad more convenient, and controls the non-invasive injection device and pulse module to inject the target drug into the injection area based on the injection parameters, avoiding significant tissue trauma and improving the safety and controllability of percutaneous drug delivery.

[0069] The following are embodiments of the non-invasive drug injection control device provided in this invention. This device and the non-invasive drug injection control method in the above embodiments belong to the same inventive concept. For details not described in detail in the embodiments of the non-invasive drug injection control device, please refer to the embodiments of the non-invasive drug injection control method described above.

[0070] Example 3

[0071] Figure 6 This is a schematic diagram of the non-invasive drug injection control device provided in Embodiment 3 of the present invention. This embodiment is applicable to performance testing during software testing. The specific structure of the non-invasive drug injection control device includes: a gripper control module 310, a non-invasive pulse electrode control module 320, and an injection module 330; wherein...

[0072] The clamp control module 310 is used to control the clamp head of the clamp to clamp the surface of the injection area so as to make the injection area bulge.

[0073] The non-invasive pulse electrode control module 320 is used to control two non-invasive pulse electrodes to be respectively disposed on both sides of the raised injection area, wherein the two non-invasive pulse electrodes are disposed in opposite directions and are at a preset angle, wherein the preset angle is less than 180 degrees.

[0074] Injection module 330 is used to control the non-invasive injection device and pulse module based on the injection parameters.

[0075] The non-invasive drug injection control method provided in this embodiment specifically includes: clamping the surface of the injection area by controlling the gripper to raise the injection area, facilitating the placement of the non-invasive pulse electrode pad on the raised injection area; further, controlling two non-invasive pulse electrode pads to be respectively positioned on both sides of the raised injection area, wherein the two non-invasive pulse electrode pads are positioned opposite each other and form a preset angle between them, wherein the preset angle is less than 180 degrees, so that the pulse rapidly applied by the pulse generator forms a pulsed electric field to quickly open the injection channel; acquiring injection parameters, and controlling the non-invasive injection device and pulse module to inject the target drug into the injection area based on the injection parameters. The technical solution provided by this embodiment of the invention, by controlling the gripper to raise the skin, makes the placement of the non-invasive electrode pad more convenient, and controls the non-invasive injection device and pulse module to inject the target drug into the injection area based on the injection parameters, avoiding significant tissue trauma and improving the safety and controllability of percutaneous drug delivery.

[0076] Based on the above embodiments, the device further includes: a support module; wherein the support module includes a support frame and a support base;

[0077] The support module is used to position the non-invasive injection device and the clamp in a preset position.

[0078] Based on the above embodiments, the device further includes: a display device;

[0079] The display device is used to acquire injection parameters and display the injection status of the target drug.

[0080] The non-invasive drug injection control device provided in the embodiments of the present invention can execute the non-invasive drug injection control method provided in any embodiment of the present invention, and has the corresponding functional modules and beneficial effects of the method.

[0081] It is worth noting that in the embodiments of the above-mentioned non-invasive drug injection control device, the various units and modules included are only divided according to functional logic, but are not limited to the above division, as long as the corresponding functions can be achieved; in addition, the specific names of each functional unit are only for easy differentiation and are not used to limit the scope of protection of the present invention.

[0082] Example 4

[0083] Figure 7 This is a schematic diagram of the structure of an electronic device provided in Embodiment 4 of the present invention. Figure 7 A block diagram is shown of an exemplary electronic device 12 suitable for implementing embodiments of the present invention. Figure 7 The electronic device 12 shown is merely an example and should not impose any limitation on the functionality and scope of use of the embodiments of the present invention.

[0084] like Figure 7 As shown, the electronic device 12 is represented in the form of a general-purpose computing electronic device. The components of the electronic device 12 may include, but are not limited to: one or more processors or processing units 16, system memory 28, and bus 18 connecting different system components (including system memory 28 and processing unit 16).

[0085] Bus 18 represents one or more of several bus architectures, including a memory bus or memory controller, a peripheral bus, a graphics acceleration port, a processor, or a local bus using any of the various bus architectures. For example, these architectures include, but are not limited to, the Industry Standard Architecture (ISA) bus, the Micro Channel Architecture (MAC) bus, the Enhanced ISA bus, the Video Electronics Standards Association (VESA) local bus, and the Peripheral Component Interconnect (PCI) bus.

[0086] Electronic device 12 typically includes a variety of computer system readable media. These media can be any available media that can be accessed by electronic device 12, including volatile and non-volatile media, removable and non-removable media.

[0087] System memory 28 may include computer system readable media in the form of volatile memory, such as random access memory (RAM) 30 and / or cache memory 32. Electronic device 12 may further include other removable / non-removable, volatile / non-volatile computer system storage media. By way of example only, storage system 34 may be used to read and write non-removable, non-volatile magnetic media (… Figure 7 Not shown; usually referred to as a "hard drive"). Although Figure 7 Not shown, a disk drive for reading and writing to a removable non-volatile disk (e.g., a "floppy disk") and an optical disk drive for reading and writing to a removable non-volatile optical disk (e.g., a CD-ROM, DVD-ROM, or other optical media) may be provided. In these cases, each drive may be connected to bus 18 via one or more data media interfaces. System memory 28 may include at least one program product having a set (e.g., at least one) of program modules configured to perform the functions of the embodiments of the present invention.

[0088] A program / utility 40 having a set (at least one) of program modules 42 may be stored, for example, in system memory 28. Such program modules 42 include, but are not limited to, an operating system, one or more application programs, other program modules, and program data. Each or some combination of these examples may include an implementation of a network environment. Program modules 42 typically perform the functions and / or methods described in the embodiments of the present invention.

[0089] Electronic device 12 can also communicate with one or more external devices 14 (e.g., keyboard, pointing device, display 24, etc.), and with one or more devices that enable a user to interact with the electronic device 12, and / or with any device that enables the electronic device 12 to communicate with one or more other computing devices (e.g., network card, modem, etc.). This communication can be performed through input / output (I / O) interface 22. Furthermore, electronic device 12 can also communicate with one or more networks (e.g., local area network (LAN), wide area network (WAN), and / or public networks, such as the Internet) via network adapter 20. Figure 7 As shown, network adapter 20 communicates with other modules of electronic device 12 via bus 18. It should be understood that, although... Figure 7As not shown, other hardware and / or software modules may be used in conjunction with electronic device 12, including but not limited to: microcode, device drivers, redundant processing units, external disk drive arrays, RAID systems, tape drives, and data backup storage systems.

[0090] Processing unit 16 executes various functional applications and acquires sample data by running programs stored in system memory 28, such as implementing the steps of a non-invasive drug injection control method provided in this embodiment. The non-invasive drug injection control method includes:

[0091] The gripper's chuck is controlled to clamp the surface of the injection area, causing the injection area to bulge.

[0092] Two non-invasive pulse electrode pads are respectively positioned on both sides of the raised injection area, wherein the two non-invasive pulse electrode pads are positioned in opposite directions and are at a preset angle, wherein the preset angle is less than 180 degrees.

[0093] The injection parameters are obtained, and the non-invasive injection device and pulse module are controlled based on the injection parameters.

[0094] Of course, those skilled in the art will understand that the processor can also implement the technical solution of the sample data acquisition method provided in any embodiment of the present invention.

[0095] Example 5

[0096] This fifth embodiment provides a computer-readable storage medium storing a computer program thereon. When executed by a processor, the program implements, for example, the steps of a non-invasive drug injection control method provided in this embodiment. The non-invasive drug injection control method includes:

[0097] The gripper's chuck is controlled to clamp the surface of the injection area, causing the injection area to bulge.

[0098] Two non-invasive pulse electrode pads are respectively positioned on both sides of the raised injection area, wherein the two non-invasive pulse electrode pads are positioned in opposite directions and are at a preset angle, wherein the preset angle is less than 180 degrees.

[0099] The injection parameters are obtained, and the non-invasive injection device and pulse module are controlled based on the injection parameters.

[0100] The computer storage medium of this invention can be any combination of one or more computer-readable media. A computer-readable medium can be a computer-readable signal medium or a computer-readable storage medium. For example, a computer-readable storage medium can be, but is not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination thereof. More specific examples (a non-exhaustive list) of computer-readable storage media include: an electrical connection having one or more wires, a portable computer disk, a hard disk, random access memory (RAM), read-only memory (ROM), erasable programmable read-only memory (EPROM or flash memory), optical fiber, portable compact disk read-only memory (CD-ROM), optical storage device, magnetic storage device, or any suitable combination thereof. In this document, a computer-readable storage medium can be any tangible medium that contains or stores a program that can be used by or in conjunction with an instruction execution system, apparatus, or device.

[0101] Computer-readable signal media may include data signals propagated in baseband or as part of a carrier wave, carrying computer-readable program code. Such propagated data signals may take various forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination thereof. Computer-readable signal media may also be any computer-readable medium other than computer-readable storage media, capable of sending, propagating, or transmitting programs for use by or in connection with an instruction execution system, apparatus, or device.

[0102] Program code contained on a computer-readable medium may be transmitted using any suitable medium, including but not limited to: wireless, wire, optical fiber, RF, etc., or any suitable combination thereof.

[0103] Computer program code for performing the operations of this invention can be written in one or more programming languages ​​or a combination thereof, including object-oriented programming languages ​​such as Java, Smalltalk, and C++, as well as conventional procedural programming languages—such as the "C" language or similar programming languages. The program code can be executed entirely on the user's computer, partially on the user's computer, as a standalone software package, partially on the user's computer and partially on a remote computer, or entirely on a remote computer or server. In cases involving remote computers, the remote computer can be connected to the user's computer via any type of network, including a local area network (LAN) or a wide area network (WAN), or it can be connected to an external computer (e.g., via the Internet using an Internet service provider).

[0104] Those skilled in the art will understand that the modules or steps of the present invention described above can be implemented using general-purpose computing devices. They can be centralized on a single computing device or distributed across a network of multiple computing devices. Optionally, they can be implemented using computer-executable program code, thereby allowing them to be stored in a storage device for execution by a computing device, or they can be fabricated as separate integrated circuit modules, or multiple modules or steps can be fabricated as a single integrated circuit module. Thus, the present invention is not limited to any particular combination of hardware and software.

[0105] Note that the above description is merely a preferred embodiment of the present invention and the technical principles employed. Those skilled in the art will understand that the present invention is not limited to the specific embodiments described herein, and various obvious changes, readjustments, and substitutions can be made without departing from the scope of protection of the present invention. Therefore, although the present invention has been described in detail through the above embodiments, the present invention is not limited to the above embodiments, and may include many other equivalent embodiments without departing from the concept of the present invention, the scope of which is determined by the scope of the appended claims.

Claims

1. A non-invasive drug injection system, characterized in that, include: Control module, non-invasive injection device, and pulse module; The pulse module includes a pulse generator and non-invasive pulse electrode pads; The number of non-invasive pulse electrode pads includes at least two; the pulse generator is connected to each non-invasive pulse electrode pad via connecting wires, and the non-invasive pulse electrode pads are in contact with the surface of the injection area; wherein... The control module is connected to the non-invasive injection device and the pulse module respectively, and is used to issue control commands to the non-invasive injection device and the pulse module; The pulse generator is used to apply an electric field pulse to the injection area through a non-invasive pulse electrode, and the electric field pulse is used to form an injection channel in the injection area. The non-invasive injection device is used to inject the target drug into a preset injection position through the injection channel; The system further includes: at least one gripper; wherein... Each clamp includes at least two clamps for clamping the surface of the injection area to raise the injection area, wherein the connection point between the two clamps and the clamp is movable; The at least two non-invasive pulse electrode pads are disposed on both sides of the raised injection area, such that the two non-invasive pulse electrode pads disposed on the surface of any injection area are disposed in opposite directions, and the two non-invasive pulse electrode pads are at a preset angle, wherein the preset angle is less than 180 degrees.

2. The system according to claim 1, characterized in that, The non-invasive injection device injects the target drug into a preset injection location using a high-pressure jet method.

3. The system according to claim 2, characterized in that, The system further includes: a support module; wherein the support module includes a support frame and a support base; The support frame is connected to the non-invasive injection device and the clamp respectively, and is used to position the non-invasive injection device and the clamp in a preset position.

4. The system according to claim 1, characterized in that, The system also includes: a power supply module; wherein... The power module is connected to the control module, the non-invasive injection device, and the pulse module respectively, and is used to provide power to the control module, the non-invasive injection device, and the pulse module.

5. The system according to claim 1, characterized in that, The system also includes: a display device; The display device is connected to the control module and is used to acquire injection parameters and display the injection status of the target drug.

6. A control module, applied to the non-invasive drug injection system as described in claim 1, characterized in that, include: A gripper control module is used to control the gripper's chucks to grip the surface of the injection area so that the injection area bulges, wherein the connection points between the two chucks and the gripper are movable; The non-invasive pulse electrode control module is used to control two non-invasive pulse electrodes to be respectively positioned on both sides of the raised injection area, wherein the two non-invasive pulse electrodes are positioned in opposite directions and are at a preset angle, wherein the preset angle is less than 180 degrees. The injection module is used to control the non-invasive injection device and pulse module based on injection parameters.

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