A method for evaluating the mouthfeel hardness of multidimensional mineral tablets

Abstract

The present invention belongs to the technical field of food measurement, and relates to a method for evaluating the mouthfeel hardness of multidimensional mineral tablets. The method comprises: (1) testing the particle properties of each raw material except magnesium stearate, including moisture, bulk density and angle of repose properties; (2) calculating the formula cumulative values ​​of moisture properties, bulk density and angle of repose of all raw materials respectively; (3) according to whether magnesium stearate is contained, substituting the formula cumulative values ​​of moisture properties, bulk density and angle of repose of all raw materials into the hardness formula to obtain the hardness value; (4) according to different hardness values, referring to the mouthfeel hardness grade table, obtaining the mouthfeel hardness of tablets prepared with the above raw materials. This method solves the shortcoming that the final mouthfeel hardness of tablets cannot be intuitively obtained in the current food tablet preparation technology, so that the final mouthfeel hardness grade confirmation can be realized at the raw material formula end, which reduces the process and testing time and effectively improves the efficiency.

Description

Technical Field

[0001] The invention relates to the field of measurement technology, and more particularly to a method for evaluating the mouthfeel hardness of a multi-dimensional mineral slice. Background Art

[0002] The hardness of tablets is closely related to the crispness of the taste, and the strength of resistance to extrusion, vibration, and impact. Tablets are required to have appropriate hardness, and the strength of hardness has a great impact on the post-production process of tablets. If the hardness of plain tablets is not enough, they are prone to cracking during packaging and transportation. If they are too hard, it will affect the chewing taste, disintegration, and release rate. If the hardness of coated tablets is not enough before coating, they are prone to fragmentation and pockmarks during coating. Correctly reflecting and testing the hardness of tablets has practical guiding significance that cannot be ignored in terms of tablet production and scientific research, and ensuring the accuracy of clinical medication.

[0003] The hardness of tablets is related to factors such as particle size, moisture content, type and amount of lubricant. Too coarse particle size will reduce the cohesion of particles, causing loose tablets and reducing tablet hardness. Too fine particle size will cause poor fluidity, resulting in insufficient filling of particles in the die hole, causing loose tablets and reducing the hardness of the finished product. Particles with relatively low moisture content have high elasticity and low plasticity and cannot be pressed into tablets; too high moisture content will cause sticking, loose tablets, etc., reducing tablet hardness; appropriate moisture content can enhance the plasticity and viscosity of particles, reduce elasticity, and thus increase tablet hardness.

[0004] In the existing technology, tablet hardness testing is mainly carried out using a hardness tester. Its advantages are that the theory and technology are relatively mature, the application range is wide, and the operation is relatively convenient. The disadvantages are: (1) only a single tablet can be tested at a time, which is inefficient; (2) after the tablet is placed, it is easy for the tablet to loosen, shift, bounce, etc., which in turn affects the detection; (3) there are large placement errors among different operators; (4) the results obtained by using a tablet hardness tester are often far from the actual taste hardness, which is prone to information mismatch problems in the subsequent market launch process. Summary of the invention

[0005] In view of this, the object of the present invention is to provide a method for determining the tablet mouthfeel and hardness of a multi-dimensional mineral tablet using multiple vitamins and minerals as raw materials, which is more convenient and more truly reflects the tablet mouthfeel and hardness.

[0006] To achieve the above object, the present invention provides the following technical solutions:

[0007] A method for evaluating the mouthfeel hardness of a multi-dimensional mineral tablet comprises the following steps:

[0008] Step 1: Test the particle properties of each raw material except magnesium stearate, including moisture, bulk density and angle of repose;

[0009] Step 2: The moisture content of the first raw material is recorded as HA1, the moisture content of the second raw material is recorded as HA2, and the moisture content of the last raw material is recorded as HA n , the unit is %; the bulk density of the first raw material is recorded as SM1, the bulk density of the second raw material is recorded as SM2, and the bulk density of the last raw material is recorded as SM n , the unit is g / cm 3 ; The repose angle of the first raw material is recorded as XZ1, the repose angle of the second raw material is recorded as XZ2, and the repose angle of the last raw material is recorded as XZ n , the unit is degree;

[0010] Step 3: Record the weight percentage of the first raw material as W1, the weight percentage of the second raw material as W2, and the weight percentage of the last raw material as W n , all in %; and according to formula (1) to formula (3), the formula cumulative values ​​of moisture properties, bulk density and angle of repose of all raw materials are calculated respectively:

[0011] HA 累 =(HA1×W1+HA2×W2+…+HA n ×W n )÷100 formula (1);

[0012] SM 累 =(SM1×W1+SM2×W2+…+SM n ×W n )÷100 formula (2);

[0013] XZ 累 =(XZ1×W1+XZ2×W2+…+XZ n ×W n )÷100 formula (3);

[0014] Step 4: When the tablet formulation does not contain magnesium stearate, the hardness of the tablet is calculated according to formula (4):

[0015]

[0016] Wherein, S is the hardness of the tablet;

[0017] When the tablet formulation contains magnesium stearate, the hardness of the tablet is calculated according to formula (5):

[0018]

[0019] Wherein, S is the hardness of the tablet;

[0020] Step 5. When the tablet hardness S is less than or equal to 3.1, its mouth hardness is level one; when the tablet hardness S is greater than 3.1 and less than or equal to 7.9, its mouth hardness is level two; when the tablet hardness S is greater than 7.9 and less than or equal to 19.9, its mouth hardness is level three; when the tablet hardness S is greater than 19.9, its mouth hardness is level four.

[0021] The present invention has the following advantages and beneficial effects:

[0022] Compared with the existing technical methods, the method provided by the present invention has the following significant advantages and progress:

[0023] 1. The method of the present invention is based on the different particle properties of the raw materials of the tablet formula, and determines the relationship between the different particle properties and the final hardness value of the tablet based on the multivariate statistical method. The final taste hardness grade can be confirmed at the raw material formula end, which reduces the process and testing time and effectively improves efficiency.

[0024] 2. In addition to determining the hardness value of the tablet, the method of the present invention can also directly obtain its corresponding mouthfeel hardness grade, which can correspond to the actual feeling of the user, effectively reducing information asymmetry. DETAILED DESCRIPTION

[0025] The present invention discloses a method for evaluating the mouthfeel hardness of multidimensional mineral slices. Those skilled in the art can refer to the content of this article and appropriately improve the parameters to achieve it. It should be particularly noted that all similar substitutions and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention. The method of the present invention has been described through preferred embodiments, and relevant personnel can obviously modify or appropriately change and combine the methods and applications described herein without departing from the content, spirit and scope of the present invention to implement and apply the present invention.

[0026] In order to better illustrate the present invention, the following embodiments are provided.

[0027] Embodiment 1:

[0028] The formula raw materials of this embodiment are vitamin premix, sorbitol and xylitol.

[0029] Step 1: Test the particle properties of vitamin premix, sorbitol and xylitol, including moisture, bulk density and angle of repose;

[0030] Step 2: The moisture content of the vitamin premix is ​​recorded as HA1, the moisture content of sorbitol is recorded as HA2, and the moisture content of xylitol is recorded as HA3, all in %; the bulk density of the vitamin premix is ​​recorded as SM1, the bulk density of sorbitol is recorded as SM2, and the bulk density of xylitol is recorded as SM3, all in g / cm 3The angle of repose of the vitamin premix was recorded as XZ1, the angle of repose of sorbitol was recorded as XZ2, and the angle of repose of xylitol was recorded as XZ3, all in degrees; the results are listed in Table 1:

[0031] Table 1 Example 1 Test data

[0032]

[0033] Step 3: Calculate the formula cumulative values ​​of moisture properties, bulk density and angle of repose of all raw materials according to formula (1) to formula (3):

[0034] HA 累 =(HA1×W1+HA2×W2+…+HA n ×W n )÷100;

[0035] SM 累 =(SM1×W1+SM2×W2+…+SM n ×W n )÷100;

[0036] XZ 累 =(XZ1×W1+XZ2×W2+…+XZ n ×W n )÷100;

[0037] The results are listed in Table 1;

[0038] Step 4: Calculate the hardness of the tablet according to formula (4):

[0039]

[0040] The results are listed in Table 1 . The tablet hardness S is equal to 7.1;

[0041] Step 5: The tablet hardness S is greater than 3.1 and less than or equal to 7.9, so its mouthfeel hardness is level 2.

[0042] Embodiment 2:

[0043] The formula raw materials of this embodiment are mineral premix, sorbitol and erythritol.

[0044] Step 1: Test the particle properties of mineral premix, sorbitol and xylitol, including moisture, bulk density and angle of repose;

[0045] Step 2: The moisture content of the mineral premix is ​​recorded as HA1, the moisture content of sorbitol is recorded as HA2, and the moisture content of erythritol is recorded as HA3, all in %; the bulk density of the mineral premix is ​​recorded as SM1, the bulk density of sorbitol is recorded as SM2, and the bulk density of erythritol is recorded as SM3, all in g / cm 3 ; The angle of repose of the mineral premix is ​​recorded as XZ1, the angle of repose of sorbitol is recorded as XZ2, and the angle of repose of erythritol is recorded as XZ3, all in degrees; the results are listed in Table 2:

[0046] Table 2 Example 2 Test data

[0047]

[0048] Step 3: Calculate the formula cumulative values ​​of moisture properties, bulk density and angle of repose of all raw materials according to formula (1) to formula (3):

[0049] HA 累 =(HA1×W1+HA2×W2+…+HA n ×W n )÷100;

[0050] SM 累 =(SM1×W1+SM2×W2+…+SM n ×W n )÷100;

[0051] XZ 累 =(XZ1×W1+XZ2×W2+…+XZ n ×W n )÷100;

[0052] The results are listed in Table 2;

[0053] Step 4: Calculate the hardness of the tablet according to formula (4):

[0054]

[0055] The results are listed in Table 2. The tablet hardness S is equal to 13.9;

[0056] Step 5: The tablet hardness S is greater than 7.9 and less than or equal to 19.9, so its mouthfeel hardness is level three.

[0057] Embodiment 3:

[0058] The formula raw materials of this embodiment are vitamin premix, mineral premix, sorbitol and magnesium stearate.

[0059] Step 1: Test the particle properties of vitamin premix, mineral premix and sorbitol, including moisture, bulk density and angle of repose;

[0060] Step 2: The moisture content of the vitamin premix is ​​recorded as HA1, the moisture content of the mineral premix is ​​recorded as HA2, and the moisture content of sorbitol is recorded as HA3, all in %; the bulk density of the vitamin premix is ​​recorded as SM1, the bulk density of the mineral premix is ​​recorded as SM2, and the bulk density of sorbitol is recorded as SM3, all in g / cm 3 The angle of repose of the vitamin premix is ​​recorded as XZ1, the angle of repose of the mineral premix is ​​recorded as XZ2, and the angle of repose of sorbitol is recorded as XZ3, all in degrees; the results are listed in Table 2:

[0061] Table 3 Example 3 Test data

[0062]

[0063] Step 3: Calculate the formula cumulative values ​​of moisture properties, bulk density and angle of repose of all raw materials according to formula (1) to formula (3):

[0064] HA 累 =(HA1×W1+HA2×W2+…+HA n ×W n )÷100;

[0065] SM 累 =(SM1×W1+SM2×W2+…+SM n ×W n )÷100;

[0066] XZ 累 =(XZ1×W1+XZ2×W2+…+XZ n ×W n )÷100;

[0067] The results are listed in Table 3;

[0068] Step 4: Calculate the hardness of the tablet according to formula (5):

[0069]

[0070] The results are listed in Table 3. The tablet hardness S is equal to 13.1;

[0071] Step 5: The tablet hardness S is greater than 7.9 and less than or equal to 19.9, so its mouthfeel hardness is level three.

[0072] Embodiment 4:

[0073] This example is a verification of the preparation of tablets in Examples 1-3.

[0074] Step 1, prepare 300 tablets of each of Examples 1-3;

[0075] Step 2: Use a tablet hardness tester to test the hardness of the three tablets, test each type 20 times, take the average value, and compare it with the calculated value. The results are listed in Table 4;

[0076] Step 3: 30 selected sensory evaluators were selected to evaluate the mouthfeel hardness of the three tablets using a four-point scale method. The results are listed in Table 4:

[0077] Table 4: Tablet validation data for Examples 1-3

[0078]

[0079] It can be seen from Table 4 that: (1) compared with the test results of the tablet hardness tester, the relative errors of the calculated hardness values ​​are all within 10%, which has good accuracy; (2) compared with the evaluation results of the sensory evaluators, the correct rates are all above 80%, which also has good accuracy.

[0080] The above description is only a specific embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A method for evaluating the mouthfeel hardness of a multidimensional mineral tablet, characterized in that It includes the following steps: Step 1: Test the particle properties of each raw material except magnesium stearate, including moisture, bulk density and angle of repose; Step 2: The moisture content of the first raw material is recorded as HA1, the moisture content of the second raw material is recorded as HA2, and the moisture content of the last raw material is recorded as HA n , the unit is %; the bulk density of the first raw material is recorded as SM1, the bulk density of the second raw material is recorded as SM2, and the bulk density of the last raw material is recorded as SM n , the unit is g / cm 3 ; The repose angle of the first raw material is recorded as XZ1, the repose angle of the second raw material is recorded as XZ2, and the repose angle of the last raw material is recorded as XZ n , the unit is degree; Step 3: Record the weight percentage of the first raw material as W1, the weight percentage of the second raw material as W2, and the weight percentage of the last raw material as W n , the unit is %; And according to formula (1) to formula (3), the formula cumulative values ​​of moisture properties, bulk density and angle of repose of all raw materials are calculated respectively: HA 累 =(HA1×W1+HA2×W2+…+HA n ×W n )÷100 formula (1); SM 累 =(SM1×W1+SM2×W2+…+SM n ×W n )÷100 formula (2); XZ 累 =(XZ1×W1+XZ2×W2+…+XZ n ×W n )÷100 formula (3); Step 4: When the tablet formulation does not contain magnesium stearate, the hardness of the tablet is calculated according to formula (4): Wherein, S is the hardness of the tablet; When the tablet formulation contains magnesium stearate, the hardness of the tablet is calculated according to formula (5): Wherein, S is the hardness of the tablet; Step 5. When the tablet hardness S is less than or equal to 3.1, its mouth hardness is level one; when the tablet hardness S is greater than 3.1 and less than or equal to 7.9, its mouth hardness is level two; when the tablet hardness S is greater than 7.9 and less than or equal to 19.9, its mouth hardness is level three; when the tablet hardness S is greater than 19.9, its mouth hardness is level four.

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