A negative pressure suction type resin filling system and filling process

Abstract

The present invention discloses a negative pressure suction type resin filling system and filling process. The negative pressure suction type resin filling system includes a premixing tank, an adsorption column and a negative pressure aspirator. The premixing tank is provided with a filling head, which is connected to the liquid inlet of the adsorption column to be filled, and a liquid seal is provided between the filling head and the premixing tank; the adsorption column includes at least one liquid inlet and at least one liquid outlet, the liquid inlet is connected to the filling head, and the liquid outlet is provided with a filter and is connected to the negative pressure aspirator through a pipeline. In the negative pressure suction type resin filling system of some examples of the present invention, the entire path through which the adsorbent flows during filling has no valve start-stop, ensuring that the resin will not be crushed by the valve mechanism to produce a large number of particles, reducing the generation of tiny particles, improving the filling quality of the adsorption column, and reducing the risk of using the adsorption column.

Description

Technical Field

[0001] The invention belongs to the technical field of medical equipment, and in particular relates to a negative pressure suction filling system for an adsorbent resin. Background Art

[0002] Immunoadsorption therapy is a blood purification technology developed in recent years. It combines highly specific antigens, antibodies, or substances with specific physical and chemical affinities (ligands) with an adsorption material (carrier) to form an adsorbent. This adsorbent is then filled into an adsorption column to selectively or specifically remove pathogenic factors from the blood, purifying the blood and alleviating the condition. However, the filling of the adsorbent requires strict control of microorganisms, endotoxins, and other substances, and the absence of visible foreign matter and microscopic particles. Blood purification adsorbents are easily damaged by external forces, producing microscopic particles. Manual filling was often used in the early stages. However, manual filling is complex and time-consuming, and can easily exceed standards for microorganisms, endotoxins, and visible foreign matter.

[0003] Existing mechanical adsorbent filling systems are mostly suitable for filling perfusion devices. The adsorption column contains a mixture of adsorbent particles and water (buffer). The resin flow through the filling system requires numerous valves to ensure precise start and stop of the system. Furthermore, the filling system requires an additional metering device to ensure accurate column loading. To improve the biocompatibility of the adsorbent in the adsorption column, immunosorbents often use soft particles such as agarose. These soft particles are sensitive to pressure and easily break into microparticles under excessive pressure. This places higher demands on the external force control of the filling system, necessitating an urgent need for a resin filling system suitable for immunosorbent columns. Summary of the Invention

[0004] The object of the present invention is to overcome at least one shortcoming of the prior art and to provide a negative pressure suction resin filling system and filling process.

[0005] The technical solution adopted by the present invention is:

[0006] The first aspect of the present invention provides:

[0007] A negative pressure suction resin filling system includes a premixing tank, an adsorption column and a negative pressure aspirator, wherein:

[0008] A premixing tank is used to mix the adsorbent to be filled, and is connected to a filling head via a pipeline. The filling head is connected to the liquid inlet of the adsorption column to be filled, and a liquid seal is formed between the filling head and the premixing tank;

[0009] The adsorption column is used to accommodate the adsorbent and includes at least one liquid inlet and at least one liquid outlet. The liquid inlet is connected to the filling head, and the liquid outlet is provided with a filter and is connected to the negative pressure aspirator through a pipeline.

[0010] In some examples of the negative pressure suction resin filling system, a liquid seal exists between the negative pressure chamber and the adsorption column.

[0011] In some examples of negative pressure suction resin filling systems, the adsorption column has two liquid outlets, which are respectively located at two ends of the column, and the liquid inlet is located in the middle of the column.

[0012] In some examples of negative pressure suction resin filling systems, the negative pressure aspirator includes a negative pressure chamber, the negative pressure chamber is connected to a liquid discharge head via a pipeline, and the negative pressure chamber is further connected to a negative pressure pump.

[0013] In some examples of the negative pressure suction resin filling system, the negative pressure chamber is further provided with a pressure relief valve.

[0014] In some examples of the negative pressure suction resin filling system, the pressure relief valve is connected to an air filter element.

[0015] In some examples of the negative pressure suction resin filling system, the negative pressure chamber is further provided with a pressure gauge.

[0016] In some examples of the negative pressure suction resin filling system, a one-way valve is provided on the pipeline between the filling head and the premixing tank and / or a one-way valve is provided on the pipeline between the liquid outlet and the negative pressure aspirator.

[0017] In some examples of the negative pressure suction resin filling system, there are multiple sets of negative pressure aspirators, filling heads and adsorption columns.

[0018] Some examples of the negative pressure suction resin filling system also include an automatic control system.

[0019] The second aspect of the present invention provides:

[0020] A negative pressure suction resin filling process is implemented by the negative pressure suction resin filling system described in the first aspect of the present invention, specifically comprising:

[0021] Dispersing the adsorbent in the diluent in a premix tank;

[0022] Keep the filling head higher than the liquid level in the premix tank, connect the filling head of the premix tank to the liquid inlet of the adsorption column, and connect the liquid outlet of the adsorption column to the negative pressure aspirator;

[0023] Open the corresponding valve, start the negative pressure suction connection, and start filling;

[0024] After filling is completed, install the protective cap and remove the adsorption column.

[0025] The beneficial effects of the present invention are:

[0026] In some examples of the negative pressure suction resin filling system of the present invention, the entire path through which the adsorbent flows during filling does not require valve start-stopping, ensuring that the resin will not be crushed by the valve mechanism to produce a large number of particles, reducing the generation of tiny particles, improving the filling quality of the adsorption column, and reducing the risk of using the adsorption column.

[0027] In some examples of the negative pressure suction resin filling system of the present invention, when switching the adsorption column, a liquid seal is set to cut off the resin liquid to ensure that the resin will not be subjected to excessive mechanical accumulation pressure to produce a large number of particles, thereby reducing the generation of tiny particles, improving the filling quality of the adsorption column, and reducing the risk of using the adsorption column.

[0028] The negative pressure suction resin filling system of some embodiments of the present invention can conveniently control the filling speed by adjusting the negative pressure of the negative pressure aspirator.

[0029] In some embodiments of the negative pressure suction resin filling system of the present invention, the negative pressure pump is a peristaltic pump, which can accurately control the filling speed, thereby avoiding excessive filling speed, which may cause turbulent bubbles in the adsorption column and affect product quality.

[0030] The negative pressure suction resin filling system of some embodiments of the present invention can be controlled by the cavity of the adsorption column to achieve precise filling, stable and reliable.

[0031] The negative pressure suction resin filling system of some embodiments of the present invention can realize the simultaneous filling of multiple adsorption columns, and has high production efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 Schematic diagrams of the structures of some examples of the present invention.

[0033] Reference numerals:

[0034] Premix tank-1, filling head-11

[0035] Adsorption column-2, liquid inlet-21, liquid outlet-22

[0036] Negative pressure aspirator-3, negative pressure chamber-31, drainage head-32, negative pressure pump-33, air filter element-34, pressure gauge-35. DETAILED DESCRIPTION

[0037] The embodiments of the present invention are described in detail below. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals represent the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and are not to be construed as limiting the present invention.

[0038] In the description of the present invention, it should be understood that descriptions involving orientations, such as up, down, front, back, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, they cannot be understood as limitations on the present invention.

[0039] In the description of the present invention, "several" means one or more, "many" means more than two, "greater than," "less than," and "exceed" are understood to exclude the number itself, while "above," "below," and "within" are understood to include the number itself. The use of "first" and "second" in the description is solely for the purpose of distinguishing technical features and should not be construed as indicating or implying relative importance, implicitly specifying the number of the indicated technical features, or implicitly specifying the order of the indicated technical features.

[0040] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be understood to indicate or imply relative importance or to implicitly indicate the quantity of the technical features indicated. Thus, features defined as "first" and "second" may explicitly or implicitly include one or more features.

[0041] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the term "connection" should be understood in a broad sense. For example, it can be a fixed connection or a movable connection, a detachable connection or a non-detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection, or mutual communication; it can be a direct connection, or an indirect connection through an intermediate medium, and it can be internal communication between two elements, indirect communication, or an interactive relationship between two elements.

[0042] The following disclosure provides many different embodiments or examples for implementing different solutions of the present invention.

[0043] Reference Figure 1 The first aspect of the present invention provides:

[0044] A negative pressure suction resin filling system includes a premixing tank 1, an adsorption column 2 and a negative pressure aspirator 3, wherein:

[0045] The premixing tank 1 is used to mix the adsorbent to be filled and is connected to a filling head 11 via a pipeline. The filling head 11 is connected to the liquid inlet 21 of the adsorption column 2 to be filled, and a liquid seal is formed between the filling head 11 and the premixing tank 1;

[0046] The adsorption column 2 is used to accommodate the adsorbent and includes at least one liquid inlet 21 and at least one liquid outlet 22. The liquid inlet 21 is connected to the filling head 11, and the liquid outlet 22 is provided with a filter and is connected to the negative pressure aspirator 3 through a pipeline.

[0047] A plurality of filling heads 11 can be provided as needed, and the filling heads 11 are arranged in parallel so as to fill multiple groups of adsorption columns 2 at the same time.

[0048] The liquid seal between the filling head 11 and the premixing tank 1 allows the flow of liquid to be cut off when the adsorption column 2 is switched after filling is completed, thereby avoiding the resin particles from being crushed due to the opening and closing of the valve.

[0049] In some examples of negative pressure suction resin filling systems, the adsorption column 2 has two liquid outlets 22, one at each end of the column, and the other at the liquid inlet 21 in the middle. This allows for faster discharge of liquid from the resin solution and helps distribute the pressure, preventing excessive pressure from causing resin rupture and particle generation.

[0050] In some examples of negative pressure suction resin filling systems, a liquid seal exists between the negative pressure chamber 31 and the adsorption column 2. This can prevent the discharged liquid from flowing back into the adsorption column 2 and affecting the filling effect.

[0051] Liquid sealing can be achieved in various ways, such as by providing a section of upwardly convex U-shaped tube.

[0052] In some examples of negative pressure suction resin filling systems, the negative pressure aspirator 3 includes a negative pressure chamber 31, which is connected to a liquid discharge head 32 via a pipeline. The negative pressure chamber 31 is also connected to a negative pressure pump 33. The negative pressure chamber 31 can accommodate a certain amount of liquid while reducing fluctuations in negative pressure.

[0053] In some examples of negative pressure suction resin filling systems, the negative pressure pump 33 is a peristaltic pump. Using a peristaltic pump is conducive to accurately controlling the filling speed, avoiding excessive filling speed, which may cause turbulent bubbles in the adsorption column 2 and affect product quality.

[0054] In some embodiments of negative pressure suction resin filling systems, the negative pressure chamber 31 is further provided with a pressure relief valve. When opened, the pressure relief valve balances the negative pressure within the negative pressure chamber 31, facilitating better regulation of the negative pressure. To facilitate automated control, the pressure relief valve can be an electromagnetic pressure relief valve.

[0055] In some examples of negative pressure suction resin filling systems, the pressure relief valve is connected to an air filter element 34. This allows the air entering the negative pressure chamber 31 to be filtered to avoid unnecessary contamination.

[0056] In some examples of negative pressure suction resin filling systems, a one-way valve is provided on the pipeline between the filling head 11 and the premixing tank 1 and / or a one-way valve is provided on the pipeline between the liquid outlet 22 and the negative pressure aspirator 3. The one-way valve can ensure one-way flow of liquid and prevent liquid backflow.

[0057] In some examples of negative pressure suction resin filling systems, the negative pressure chamber 31 is further provided with a pressure gauge 35. The pressure gauge 35 can well indicate the pressure. Further, automatic control can be achieved based on the pressure and its changes.

[0058] In some examples of negative pressure suction resin filling systems, there are multiple sets of negative pressure aspirators 3, filling heads 11 and adsorption columns 2. This allows filling of multiple adsorption columns 2 to be achieved simultaneously, thereby improving production efficiency.

[0059] Some negative pressure resin filling systems also include an automated control system. When the adsorption column 2 is filled with solid adsorbent, the filtration surface area decreases instantly, increasing resistance and nearly stagnating liquid flow, leading to a rapid drop in pressure. By monitoring system pressure changes, automated control can be easily implemented.

[0060] Example 1:

[0061] A negative pressure suction resin filling system includes a premixing tank 1, an adsorption column 2 and a negative pressure aspirator 3, wherein:

[0062] A premixing tank 1 is used to mix the adsorbent to be filled, and is connected to a plurality of filling heads 11 via pipelines. The filling heads 11 are connected to the liquid inlet 21 of the adsorption column 2 to be filled, and a liquid seal is formed between the filling heads 11 and the premixing tank 1;

[0063] The adsorption column 2 is used to accommodate the adsorbent. The adsorption column 2 has two liquid outlets 22, one at each end of the column, and the other at the middle of the column. The liquid inlet 21 is connected to the filling head 11. The liquid outlet 22 is provided with a filter and is connected to the negative pressure aspirator 3 through a pipeline. A liquid seal is formed between the negative pressure chamber 31 and the adsorption column 2.

[0064] The negative pressure suction device 3 includes a negative pressure chamber 31, which is connected to a liquid discharge head 32 through a pipeline. The negative pressure chamber 31 is also connected to a peristaltic pump, a pressure gauge 35, and a pressure relief valve. The pressure relief valve is connected to an air filter element 34. Multiple negative pressure suction devices 3 are arranged in parallel.

[0065] The second aspect of the present invention provides:

[0066] A negative pressure suction resin filling process is implemented by the negative pressure suction resin filling system described in the first aspect of the present invention, specifically comprising:

[0067] Dispersing the adsorbent in the diluent in a premix tank;

[0068] Keep the filling head higher than the liquid level in the premix tank, connect the filling head of the premix tank to the liquid inlet of the adsorption column, and connect the liquid outlet of the adsorption column to the negative pressure aspirator;

[0069] Open the corresponding valve, start the negative pressure suction connection, and start filling;

[0070] After filling is completed, install the protective cap and remove the adsorption column.

[0071] The above is a further detailed description of the present invention and should not be considered as a limitation on the specific implementation of the present invention. For those skilled in the art, simple deductions or substitutions that do not depart from the concept of the present invention are within the scope of protection of the present invention.

Claims

1. A negative pressure suction resin filling system, comprising a premixing tank, an adsorption column and a negative pressure aspirator, wherein: A premixing tank is used to mix the adsorbent to be filled, and is connected to a filling head via a pipeline. The filling head is connected to the liquid inlet of the adsorption column to be filled, and a liquid seal is formed between the filling head and the premixing tank; An adsorption column for containing an adsorbent, comprising at least one liquid inlet and two liquid outlets, the liquid outlets being located at both ends of the column, the liquid inlet being connected to the filling head, the liquid inlet being located in the middle of the column, and the liquid outlet being provided with a filter and connected to the negative pressure aspirator through a pipeline; The negative pressure aspirator comprises a negative pressure chamber, a liquid seal exists between the negative pressure chamber and the adsorption column, the negative pressure chamber is connected to a liquid discharge head via a pipeline, and the negative pressure chamber is also connected to a negative pressure pump.

2. The negative pressure suction resin filling system according to claim 1, characterized in that: The negative pressure chamber is further provided with a pressure relief valve and / or a pressure gauge.

3. The negative pressure suction resin filling system according to claim 2, characterized in that: The pressure relief valve is connected to an air filter element.

4. The negative pressure suction resin filling system according to claim 1, characterized in that: A one-way valve is provided on the pipeline between the filling head and the premixing tank and / or a one-way valve is provided on the pipeline between the liquid outlet and the negative pressure aspirator.

5. The negative pressure suction resin filling system according to any one of claims 1 to 4, characterized in that: It has multiple sets of negative pressure aspirators, filling heads and adsorption columns.

6. The negative pressure suction resin filling system according to any one of claims 1 to 4, characterized in that: Also includes automatic control system.

7. A negative pressure suction resin filling process, implemented by the negative pressure suction resin filling system according to any one of claims 1 to 6, specifically comprising: Dispersing the adsorbent in the diluent in a premix tank; Keep the filling head higher than the liquid level in the premix tank, connect the filling head of the premix tank to the liquid inlet of the adsorption column, and connect the liquid outlet of the adsorption column to the negative pressure aspirator; Open the corresponding valve, start the negative pressure suction connection, and start filling; After filling is completed, install the protective cap and remove the adsorption column.

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