A pressing component for a kit and a detection instrument
By using an eccentric mechanism in the top pressure assembly of the kit, the rotational movement of the drive motor is converted into the reciprocating linear movement of the top pressure member, the problem of insufficient or excessive top pressure in the prior art is solved, and the stable top pressure and sealing structure of the kit are protected.
Patent Information
- Application Number
- CN202211146355.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2022-09-20
- Publication Date
- 2025-06-10
- Estimated Expiration
- 2042-09-20
AI Technical Summary
In the prior art, it is difficult for the driving mechanism to accurately control the reciprocating travel of the lower press plate, resulting in insufficient or excessive top pressure, which may cause leakage or deformation of the seal structure.
An eccentric mechanism is adopted, including an eccentric member and a transmission member. By driving the motor, the eccentric member is driven to rotate. The rolling contact between the eccentric member and the transmission member is converted into a reciprocating linear motion of the top press, ensuring the stable movement of the top press.
Through the use of the eccentric mechanism, the reciprocating travel of the top pressure member can be accurately controlled, reducing the probability of insufficient or excessive top pressure, ensuring the stable top pressure of the kit, and avoiding leakage and deformation of the seal structure.
Smart Images

Figure CN115651801B_ABST
Abstract
Description
Technical Field
[0001] The present invention belongs to the field of biological detection instruments, and particularly relates to a pressing component for a reagent kit and a detection instrument. Background Art
[0002] PCR is the abbreviation of polymerase chain reaction. It uses a section of DNA as a template and, with the participation of DNA polymerase and nucleotide substrates, amplifies this section of DNA to a sufficient quantity for structural and functional analysis. It is widely used in the detection of biological samples (such as saliva, blood, urine, etc.) and has important applications in the detection of infectious diseases. To avoid false positive test results caused by reagent contamination, a reagent kit is designed in related technologies. The reagent kit has two relatively slidable parts. Before detection, the reagent is sealed in a reagent tube and placed in one part of the reagent kit. During detection, the sealing structure on the reagent tube is punctured by a puncturing structure provided in the other part of the reagent kit, which can prevent cross-contamination of nucleic acid amplification products. Therefore, a pressing mechanism is required to press the reagent kit. In related technologies, a linear drive mechanism is generally used to drive a lower pressing plate to perform reciprocating linear motion to achieve pressing of the reagent kit. To ensure the puncturing effect, the reagent kit has very high requirements for the pressing degree: if the pressing degree is insufficient, it is easy for the puncturing structure not to fully enter, which may cause leakage; if over-pressed, it is easy for the sealing structure to be excessively squeezed and deformed, resulting in the inability to pump the liquid in the tube. The drive mechanisms in related technologies cannot accurately control the reciprocating movement stroke of the lower pressing plate, and problems such as insufficient pressing or over-pressing may occur during the detection process. Summary of the Invention
[0003] The present invention aims to at least partly solve one of the above technical problems in the related technologies. Therefore, the present invention adopts the following technical solution: A pressing component for a reagent kit includes a drive motor and a pressing member for pressing the reagent kit along a set direction, and further includes an eccentric mechanism disposed between the drive motor and the pressing member. The eccentric mechanism is used to drive the pressing member to perform reciprocating linear motion along the set direction under the drive of the drive motor. The eccentric mechanism includes: an eccentric member disposed on the output shaft of the drive motor and driven to rotate around a set axis; and a transmission member disposed on the pressing member. Wherein, an eccentric groove is provided on the eccentric member around the set axis, and the transmission member has a rolling section extending into the eccentric groove, and the rolling section is in rolling contact with the inner wall of the eccentric groove.
[0004] The present invention has the following beneficial effects:
[0005] 1. Rotate the eccentric member by driving the driving motor. The eccentric member acts on the transmission member through the inner wall of the eccentric groove, and then converts the rotational motion into the reciprocating linear motion of the pressing member through the transmission member. Since the eccentric member rotates around the set axis driven by the driving motor, its rotation trajectory is stable, which can ensure that the reciprocating movement stroke of the pressing member remains unchanged, thereby reducing the occurrence probability and severity of the situation where the pressing is not in place or excessive pressing occurs;
[0006] 2. When the eccentric member drives the pressing member to perform reciprocating linear motion through the transmission member, due to the rolling contact between the rolling section and the inner wall of the eccentric groove, the frictional force between the rolling section and the inner wall of the eccentric groove is very small, and the wear of both can be ignored, so it has no impact on the preset reciprocating movement stroke of the pressing member, which can further reduce the occurrence probability and severity of the situation where the pressing is not in place or excessive pressing occurs.
[0007] Preferably, the eccentric member includes a first eccentric cam. A groove is provided on the side of the first eccentric cam facing the transmission member, and a second eccentric cam is arranged in the groove. The eccentric groove is formed between the first eccentric cam and the second eccentric cam. The overall eccentric groove formed by the cooperation of the first eccentric cam and the second eccentric cam can form a complete circle. In this way, the driving motor only needs to drive the eccentric member to rotate in one direction to achieve the purpose of driving the pressing member to reciprocate through the transmission member.
[0008] Preferably, the eccentric member includes a substrate, and the eccentric groove is a spiral groove provided on the substrate. The spiral groove is located on the side of the substrate facing the transmission member. Setting the spiral groove on the substrate as the eccentric groove requires the driving motor to control the eccentric member to rotate clockwise and counterclockwise respectively through forward and reverse rotation to achieve the purpose of driving the pressing member to reciprocate through the transmission member. This setting has the following advantages: for reagent kits of different model sizes, the required reciprocating movement stroke of the pressing member is different. By setting the spiral groove as the eccentric groove, the reciprocating movement stroke of the pressing member can be adjusted by adjusting the number of rotation turns of the driving motor in a single direction, so as to adapt to reagent kits of different model sizes.
[0009] Preferably, the transmission member includes a fixed section, the rolling section is rotatably arranged on the fixed section, and the transmission member is fixedly arranged on the pressing member through the fixed section.
[0010] Preferably, the fixed section has a round shaft, the rolling section is a bearing, the inner ring of the bearing is in interference fit with the round shaft, and the outer ring of the bearing is in rolling contact with the inner wall of the eccentric groove. The friction between the inner ring and the outer ring of the bearing is very small. By using the bearing to realize the rotational setting of the rolling section relative to the fixed section, the friction can be further reduced.
[0011] Preferably, the pressing device further includes a base, the driving motor is disposed on the base, and a guiding member for restricting the moving direction of the pressing member is disposed between the pressing member and the base. By providing the guiding member to limit the moving direction of the pressing member, it is possible to prevent the pressing member from shifting or shaking during the pressing of the reagent kit, ensuring a stable puncturing process.
[0012] Preferably, the pressing member includes an upper pressing plate and a lower pressing plate, the transmission member is disposed on the upper pressing plate, the lower pressing plate is used for performing a pressing action on the reagent kit, and an adaptive adjustment assembly for adjusting the distance between the two is disposed between the upper pressing plate and the lower pressing plate; the adaptive adjustment assembly includes a connecting member and an elastic member, the upper pressing plate is located at one end of the connecting member and the two can move relative to each other along a set direction, the lower pressing plate is located at the other end of the connecting member and the two remain relatively fixed; the elastic member always applies a force to the upper pressing plate and the lower pressing plate such that the upper pressing plate and the lower pressing plate tend to move away from each other, and a limiting member for restricting the upper pressing plate from detaching from the connecting member is disposed on the connecting member. During the production and manufacturing process of the reagent kit, dimensional tolerances will inevitably exist, and the reciprocating moving stroke of the pressing member is set according to the designed size of the reagent kit. Therefore, due to the existence of dimensional tolerances, problems such as incomplete pressing or excessive pressing may occur. By adaptively adjusting the distance between the upper pressing plate and the lower pressing plate through the adaptive adjustment assembly, the upper pressing plate can automatically adapt to the size of the reagent kit, ensuring that there is no incomplete pressing or excessive pressing.
[0013] Preferably, the minimum pressing force required for the reagent kit is Pmin, and the maximum pressing force that the reagent kit can withstand is Pmax; the force applied by the elastic member to the lower pressing plate is F, and F has a minimum value Fmin and a maximum value Fmax, where Pmin < Fmin < Fmax < Pmax. The force F applied by the elastic member to the lower pressing plate is the force applied by the lower pressing plate to the reagent kit. Therefore, Fmin > Pmin, which can ensure that from the moment the lower pressing plate contacts the reagent kit until it is completely pressed in place, the lower pressing plate always presses the reagent kit in a single direction and will not bounce back in the return direction due to the reverse force of the reagent kit overcoming the elastic force of the elastic member. This can ensure that the pressing process of the lower pressing plate on the reagent kit is fast, powerful, and directly in place, avoiding leakage.
[0014] Preferably, the upper pressing plate is provided with a perforation along the set direction, the connecting member passes through the perforation, the limiting member is a flange formed at one end of the connecting member, and a blocking portion adapted to the flange is disposed in the perforation, and the blocking portion presses against the flange under the action of the elastic member.
[0015] Preferably, the connecting member is columnar, a linear bearing is sleeved outside the connecting member, the linear bearing is fixedly connected to the upper pressing plate, and the linear bearing has a blocking portion extending into the through hole.
[0016] Preferably, the elastic member is a spring, and the spring is sleeved outside the linear bearing; the linear bearing protrudes radially outward to form an annular protrusion, one end of the spring is arranged on the annular protrusion, and the other end of the spring is arranged on the lower pressing plate. This has a good positioning effect on the spring, can prevent the spring from radially shifting during the compression process, and further ensure that the direction of the force exerted by the spring on the lower pressing plate remains unchanged.
[0017] The present invention also adopts the following technical solution: A detection instrument for a reagent kit, including a housing, a bracket, an extraction and amplification assembly, an optoelectronic assembly, and a pressing assembly for a reagent kit as described in any one of the above technical solutions. Among them, the bracket is arranged inside the housing, and the extraction and amplification assembly, the optoelectronic assembly, and the pressing assembly are all arranged on the bracket. Since this detection instrument adopts the above pressing assembly, it can maintain the moving stroke of the pressing member during the pressing process, thereby reducing the probability and severity of insufficient pressing or excessive pressing, ensuring good electrical conductivity after piercing, and making the operation of pumping the reagent smooth.
[0018] Additional aspects and advantages of the present invention will be given in part in the following description, will become apparent in part from the following description, or will be understood through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] Figure 1 is a schematic structural diagram of a pressing assembly for a reagent kit provided in Embodiment 1;
[0020] Figure 2 is an exploded view of the pressing assembly in Embodiment 1;
[0021] Figure 3 is a schematic structural diagram of the eccentric mechanism;
[0022] Figure 4 is a cross-sectional view of the pressing member;
[0023] Figure 5 is a front view of the eccentric member in Embodiment 2;
[0024] Figure 6 is a schematic structural diagram of a pressing assembly for a reagent kit provided in Embodiment 3;
[0025] Figure 7 is a schematic structural diagram of the pressing member in Embodiment 3;
[0026] Figure 8It is a cross-sectional view of the pressing member in the third embodiment;
[0027] Figure 9 It is a schematic diagram of the principle of setting a reciprocating movement stroke for the pressing member;
[0028] Figure 10 It is a schematic diagram of a detection instrument for a kit provided in the fourth embodiment;
[0029] Figure 11 It is an internal schematic diagram of the detection instrument in the fourth embodiment.
[0030] Wherein: 1. Driving motor, 2. Pressing member, 20. Upper pressing plate, 200. Perforation, 21. Lower pressing plate, 22. Bolt, 23. Connecting member, 230. Flange, 24. Elastic member, 25. Linear bearing, 250. Blocking portion, 251. Ring-shaped protrusion, 3. Eccentric mechanism, 30. Eccentric groove, 31. Transmission member, 310. Fixed section, 311. Rolling section, 32. First eccentric cam, 33. Second eccentric cam, 34. Substrate, 4. Base, 40. Through hole, 41. Guide member, 5. Kit, 50. Upper box body, 51. Lower box body, 6. Housing, 7. Bracket, 8. Extraction and amplification assembly, 9. Photoelectric assembly. Detailed implementation manners
[0031] The embodiments of the present invention will be described in detail below. The examples of the embodiments are shown in the drawings, wherein the same or similar reference numerals represent the same or similar elements or elements with the same or similar functions throughout. The embodiments described below with reference to the drawings are exemplary and are intended to explain the present invention and should not be construed as limiting the present invention.
[0032] The embodiments of the present invention will be described below with reference to the drawings.
[0033] Embodiment 1: This embodiment provides a pressing assembly for a kit, as Figures 1 to 3As shown in the figure, the pressing component includes a driving motor 1 and a pressing member 2 for pressing the reagent kit along a set direction, and further includes an eccentric mechanism 3 disposed between the driving motor 1 and the pressing member 2. The eccentric mechanism 3 is configured to drive the pressing member 2 to perform a reciprocating linear motion along the set direction under the drive of the driving motor 1. Specifically, the eccentric mechanism 3 includes an eccentric member and a transmission member 31. Among them, the eccentric member is disposed on the output shaft of the driving motor 1 and is driven to rotate around a set axis. The set axis herein is the central axis of the output shaft of the driving motor 1, and the transmission member 31 is disposed on the pressing member 2. In this embodiment, an eccentric groove 30 is provided on the eccentric member around the set axis. The transmission member 31 has a rolling section 311 extending into the eccentric groove 30, and the rolling section 311 is in rolling contact with the inner wall of the eccentric groove 30. When applying the pressing component, the driving motor 1 is used to drive the eccentric member to rotate. The eccentric member acts on the transmission member 31 through the inner wall of the eccentric groove 30, and then the rotational motion is converted into the reciprocating linear motion of the pressing member 2 through the transmission member 31. During the detection, the reagent kit is placed at a set working station, and then the pressing component is used to press the reagent kit. Specifically, the driving motor 1 is controlled to drive the pressing member 2 to press the reagent kit. After the puncture is completed, the reagent tube is communicated with the extraction pool. Then, the stability of the reagent kit is ensured by the pressing action of the pressing component on the reagent kit. Until after the mixing, amplification, and detection steps are completed, the pressing member moves upward to separate from the reagent kit, and then the above pressing operation is performed after the next reagent kit is placed.
[0034] The reciprocating movement stroke of the pressing member is preset according to the specific size of the reagent kit (the movement stroke of the pressing member is controlled by controlling the number of rotation turns of the output shaft of the driving motor). Since the eccentric member can rotate around the set axis under the drive of the driving motor 1, its rotation trajectory is stable, that is, it can ensure that the reciprocating movement stroke of the pressing member 2 remains unchanged. In this way, when pressing the reagent kits one by one, the occurrence probability and severity of insufficient pressing or excessive pressing can be reduced. In addition, when the eccentric member drives the pressing member 2 to perform a reciprocating linear motion through the transmission member 31, since the rolling section 311 is in rolling contact with the inner wall of the eccentric groove 30, the frictional force between the rolling section 311 and the inner wall of the eccentric groove 30 is very small, and the wear of both can be ignored, so it has no influence on the preset reciprocating movement stroke of the pressing member 2. This can further reduce the occurrence probability and severity of insufficient pressing or excessive pressing.
[0035] Specifically in this embodiment, the eccentric member includes a first eccentric cam 32. A groove is provided on the side of the first eccentric cam 32 facing the transmission member 31. A second eccentric cam 33 is arranged in the groove. An eccentric groove 30 is formed between the first eccentric cam 32 and the second eccentric cam 33. The entire eccentric groove 30 formed by the cooperation of the first eccentric cam 32 and the second eccentric cam 33 can form a complete circle. In this way, the driving motor 1 only needs to drive the eccentric member to rotate in one direction to achieve the purpose of driving the pressing member 2 to reciprocate through the transmission member 31.
[0036] The transmission member 31 in the pressing assembly includes a fixed section 310. A rolling section 311 is rotatably arranged on the fixed section 310. The transmission member 31 is fixedly arranged on the pressing member 2 through the fixed section 310. Specifically in this embodiment, the fixed section 310 is a circular shaft, and the rolling section 311 is a bearing. The inner ring of the bearing is in interference fit with the circular shaft, and the outer ring of the bearing is in rolling contact with the inner wall of the eccentric groove 30. The friction between the inner ring and the outer ring of the bearing is very small. By using the bearing to realize the rotational setting of the rolling section 311 relative to the fixed section 310, the friction can be further reduced. In addition, during assembly, a hole adapted to the circular shaft is provided on the pressing member 2. One end of the circular shaft is tightly inserted into the hole in a fitting manner, and the above-mentioned bearing is arranged at the other end of the circular shaft. It can be understood that in other embodiments, the fixed section 310 can also be set to have a section of circular shaft and also have a structure for fixedly installing with the pressing member 2. This structure can be a threaded rod or a welding plate, etc. Correspondingly, this structure can be threadedly connected to the pressing member 2 or directly welded to the pressing member 2, that is, it is not necessary to completely set the fixed section 310 as a circular shaft.
[0037] The pressing device further includes a base 4. The driving motor 1 is arranged on the base 4. A guide member 41 for restricting the moving direction of the pressing member 2 is arranged between the pressing member 2 and the base 4. By arranging the guide member 41 to limit the moving direction of the pressing member 2, it is prevented that the pressing member 2 deviates or shakes during the pressing process of the reagent kit, ensuring the stability of the puncture process. Specifically in this embodiment, the guide member 41 is a guide post. Figure 4As shown in the figure, the pressing member 2 includes an upper pressing plate 20 and a lower pressing plate 21. Among them, the lower pressing plate 21 is arranged below the base 4, and a through hole 40 for the upper pressing plate 20 to pass through is also arranged on the base 4. The upper pressing plate 20 and the lower pressing plate 21 are fixedly connected by bolts 22. Specifically, step holes are arranged on the upper pressing plate 20. One end of the bolt 22 abuts against the step hole through its head, and the other end of the bolt 22 is provided with an internal thread hole. Screws are arranged in the step holes on the lower pressing plate 21, and the screws are screwed into the internal thread holes. It can be understood that the pressing member 2 can also be integrally formed, that is, instead of using two pressing plates, a thicker plate is directly used as the pressing member 2. In this embodiment, the structure of the upper pressing plate 20 and the lower pressing plate 21 can greatly reduce the weight of the pressing member 2, so that the power consumption of the driving motor 1 can be reduced.
[0038] Embodiment 2: This embodiment also provides a pressing assembly for a kit. The difference between this embodiment and the above embodiment is that the structure of the eccentric groove 30 in this embodiment is different from that in the above embodiment. Specifically, as Figure 5 shown in the figure, the eccentric member in this embodiment includes a base plate 34, and the eccentric groove 30 is a spiral groove arranged on the base plate 34, and the spiral groove is located on one side of the base plate 34 facing the transmission member.
[0039] Based on the above differences, a spiral groove is arranged on the base plate 34 as the eccentric groove 30. In this way, it is necessary for the driving motor 1 to control the eccentric member to rotate clockwise and counterclockwise respectively through forward and reverse rotation in order to achieve the purpose of driving the pressing member 2 to reciprocate through the transmission member 31. Such a setting has the following advantages: for kits of different model sizes, the reciprocating movement stroke of the pressing member 2 required is different. By setting the spiral groove as the eccentric groove 30, the reciprocating movement stroke of the pressing member 2 can be adjusted by adjusting the number of rotation turns of the driving motor 1 in a single direction, so as to adapt to kits of different model sizes.
[0040] Embodiment 3: This embodiment also provides a pressing assembly for a kit. The difference between this embodiment and the above embodiment is that the pressing member 2 in this embodiment is different from that in the above embodiment. As Figures 6 to 8As shown in , in this embodiment, an adaptive adjustment component for adjusting the distance between the upper pressing plate 20 and the lower pressing plate 21 is provided. Specifically, the adaptive adjustment component includes a connecting member 23 and an elastic member 24, the upper pressing plate 20 is located at one end of the connecting member 23 and the two can move relative to each other along a set direction, and the lower pressing plate 21 is located at the other end of the connecting member 23 and the two remain relatively fixed; the elastic member 24 always applies force to the upper pressing plate 20 and the lower pressing plate 21 so that the upper pressing plate 20 and the lower pressing plate 21 have a tendency to move away from each other, and the connecting member 23 is provided with a limiter for limiting the upper pressing plate 20 from being separated from the connecting member 23. Among them, the transmission member 31 is provided on the upper pressing plate 20, so that the upper pressing plate 20 is driven to perform reciprocating linear motion through the driving mechanism; the lower pressing plate 21 is assembled on the upper pressing plate 20 through the above-mentioned adaptive adjustment component, so that when the upper pressing plate 20 performs reciprocating linear motion, the lower pressing plate 21 can be driven to follow the action.
[0041] In the process of manufacturing the test kit, there will inevitably be dimensional tolerances. There is a heating step in the testing process. When heated, the test kit may expand and increase in size. The reciprocating travel of the top pressure piece 2 is set according to the design size of the test kit. Therefore, due to dimensional tolerances or thermal expansion, the top pressure may not be in place or may be excessive. By setting an adaptive adjustment component to adaptively adjust the distance between the upper pressure plate 20 and the lower pressure plate 21, the top pressure piece 2 can automatically adapt to the size of the test kit to ensure that the top pressure is not in place or excessive. Figure 9 The working principle of the adaptive adjustment component is explained as follows:
[0042] The reagent kit 5 is arranged below the top pressing assembly, and the reagent kit 5 includes an upper box body 50 and a lower box body 51. A puncture structure is arranged in the upper box body 50, and a reagent tube is arranged in the lower box body 51. A sealing film is arranged at the mouth of the reagent tube. The above structure of this type of reagent kit belongs to the prior art and will not be described here. The upper box body 50 is set to move downward by a distance L relative to the lower box body 51 so that the sealing film can be punctured by the puncture structure and the puncture structure can be extended to a suitable position in the reagent tube (this position ensures smooth operation of pumping the reagent). Figure 9The pressing member 2 in two different positions is shown, namely, the pressing member 2 is at the highest point of the reciprocating linear motion, and the pressing member 2 moves downward to the position just in contact with the kit 5. The stroke of the upper pressing plate 20 for a single forward or single return trip is set as H. During design and manufacture, the stroke H of the upper pressing plate 20 needs to be preset according to the pressing distance of the kit 5. When the lower pressing plate 21 is at the highest position, the distance between the lower surface of the lower pressing plate 21 and the upper surface of the upper box body 50 is set as P. Then, in an ideal state, H can be designed as H = L + P. However, considering factors such as the manufacturing tolerance and the expansion caused by the temperature change during the detection process as described above, in this embodiment, H is designed as H = L + P + Δh, where Δh is the inevitable tolerance in the production and manufacture of the kit 5 and can be obtained by measuring the batch-produced kits 5.
[0043] That is to say, when presetting H, it is set according to the size of the kit with a smaller size caused by tolerance reasons, so that the pressing can be ensured to be in place for the kit with a smaller size. For those kits with a manufacturing size larger than the designed size or those kits with an increased size during the heating process, the compression of the elastic member 24 can be used to offset the above-mentioned size change. Thus, the pressing assembly provided in this embodiment can press the kit in place without over-pressing. For the pressing member 2 in the related art that does not have the self-adaptive ability, H is designed as H = L + P, and only those kits that meet the design size requirements can achieve a better pressing effect. It will not be able to press the kit with a smaller size due to tolerance during manufacture in place, and will over-press the kit with a larger size due to tolerance during manufacture. Correspondingly, it will also over-press the kit with an increased size due to heating during the detection process.
[0044] The minimum top pressure force required for the kit is Pmin, and the maximum top pressure force that the kit can withstand is Pmax; the force exerted by the elastic member 41 on the lower pressing plate 21 is set as F. When the lower pressing plate 21 is not in contact with the kit, F has a minimum value Fmin; when the lower pressing plate 21 presses on the kit and the upper pressing plate 20 reaches the stroke end point of the reciprocating linear motion (i.e., the lowest point), F has a maximum value Fmax, where Pmin < Fmin < Fmax < Pmax. The force F exerted by the elastic member 24 on the lower pressing plate 21 is the force exerted by the lower pressing plate 21 on the kit. Therefore, Fmin > Pmin, which can ensure that during the process from the lower pressing plate 21 coming into contact with the kit until it is completely pressed in place, the lower pressing plate 21 always presses on the kit in a single direction and will not bounce back towards the return stroke direction due to the reverse force of the kit overcoming the elastic force of the elastic member 24. In this way, it can ensure that the pressing process of the lower pressing plate 21 on the kit is fast, powerful, and directly in place, avoiding leakage. Of course, it can be understood that after the pressing is in place, during the detection process, if the kit expands due to heating, the expanded kit can exert a greater force on the lower pressing plate, and at this time, the elastic member will be compressed to move the lower pressing plate upward, so that the pressing assembly realizes self - adaptation to this size change.
[0045] In this embodiment, the upper pressing plate 20 is provided with a through - hole 200 along the set direction, the connecting member 23 is arranged through the through - hole 200, the limiting member is a flange 230 formed at one end of the connecting member 23, and a blocking portion 250 adapted to the flange 230 is arranged in the through - hole 200. The blocking portion 250 presses against the flange 230 under the action of the elastic member 24. Further, the connecting member 23 is column - shaped, a linear bearing 25 is sleeved outside the connecting member 23, the linear bearing 25 is fixedly connected with the upper pressing plate 20, and the linear bearing 25 has a blocking portion 250 extending into the through - hole 200.
[0046] In addition, the elastic member 24 in this embodiment is a spring, and the spring is sleeved outside the linear bearing 25; the linear bearing 25 protrudes radially outward to form an annular protrusion 251, one end of the spring is arranged on the annular protrusion 251, and the other end of the spring is arranged on the lower pressing plate 21. This has a good positioning effect on the spring, can prevent the spring from radially shifting during the compression process, and further ensures that the direction of the force exerted by the spring on the lower pressing plate 21 remains unchanged.
[0047] Example 4: This example provides a detection instrument for a kit, including a housing, a bracket, an extraction and amplification component, an optoelectronic component, and a pressing component for the kit as described in any of the above technical solutions. Among them, the bracket is arranged inside the housing, and the extraction and amplification component, the optoelectronic component, and the pressing component are all arranged on the bracket. Since this detection instrument adopts the above pressing component, it can maintain the moving stroke of the pressing member 2 during the pressing process, thereby reducing the probability and severity of insufficient pressing or excessive pressing, ensuring good electrical conductivity after piercing, and making the operation of pumping the reagent smooth.
[0048] When detecting the sample in the kit, the pressing component provided in this example acts as a unit in the detection instrument to press the kit. Figure 10 and Figure 11 Fig. shows a schematic structural diagram of the detection instrument applying this pressing component. The detection instrument includes a housing 6, a bracket 7, an extraction and amplification component 8, an optoelectronic component 9, and this pressing component. Among them, the bracket 7 is arranged inside the housing 6, and the extraction and amplification component 8, the optoelectronic component 9, and the pressing component are all arranged on the bracket 7. Since this detection instrument adopts the above pressing component, it can greatly reduce the probability and severity of insufficient pressing or excessive pressing when pressing the kit, ensure good electrical conductivity after the sealing structure is pierced, and make the operation of pumping the reagent smooth.
[0049] During detection, place the kit on the set working station, and then drive the pressing member 2 to press the kit by controlling the driving motor 1. After the puncture is completed, the reagent tube is in communication with the extraction pool, and then steps such as mixing, amplification, and detection are carried out. During this process, the extraction and amplification component completes the mixing and amplification steps, and the optoelectronic component completes the detection step.
[0050] In the present invention, unless otherwise clearly specified or limited in the embodiments, terms such as "installation", "connection", "connection", and "fixation" in the embodiments should be understood in a broad sense. For example, the connection can be a fixed connection, a detachable connection, or integrated. It can be understood that it can also be a mechanical connection, an electrical connection, etc.; of course, it can also be directly connected, or indirectly connected through an intermediate medium, or it can be the communication inside two components, or the interaction relationship between two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to the specific implementation situations.
[0051] Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those of ordinary skill in the art can make changes, modifications, substitutions, and variations to the above embodiments within the scope of the present invention.
Claims
1. A pressing component for a kit, comprising a driving motor (1) and a pressing member (2) for pressing the kit along a set direction, Characterized in that, It further comprises an eccentric mechanism (3) disposed between the driving motor (1) and the pressing member (2), and the eccentric mechanism (3) is used to drive the pressing member (2) to perform a reciprocating linear motion along the set direction under the drive of the driving motor (1). The eccentric mechanism (3) includes: An eccentric member, which is disposed on the output shaft of the driving motor (1) and is driven to rotate around a set axis; and, A transmission member (31), which is disposed on the pressing member (2); Wherein, an eccentric groove (30) is provided on the eccentric member around the set axis, the transmission member (31) has a rolling section (311) extending into the eccentric groove (30), and the rolling section (311) is in rolling contact with the inner wall of the eccentric groove (30); The pressing member (2) includes an upper pressing plate (20) and a lower pressing plate (21), the transmission member (31) is disposed on the upper pressing plate (20), the lower pressing plate (21) is used to perform a pressing action on the kit, and an adaptive adjustment component for adjusting the distance between the two is provided between the upper pressing plate (20) and the lower pressing plate (21); The adaptive adjustment component includes a connecting member (23) and an elastic member (24). The upper pressing plate (20) is located at one end of the connecting member (23) and the two can move relative to each other along the set direction. The lower pressing plate (21) is located at the other end of the connecting member (23) and the two remain relatively fixed; The elastic member (24) always applies a force to the upper pressing plate (20) and the lower pressing plate (21) such that the upper pressing plate (20) and the lower pressing plate (21) tend to move away from each other, and the connecting member (23) is provided with a limiting member for restricting the upper pressing plate (20) from detaching from the connecting member (23); The minimum pressing force required for the kit is Pmin, and the maximum pressing force that the kit can withstand is Pmax; The force applied by the elastic member (24) to the lower pressing plate (21) is F, and F has a minimum value Fmin and a maximum value Fmax, wherein, Pmin < Fmin < Fmax < Pmax.
2. The pressing component for a kit according to claim 1, Characterized in that, The eccentric member includes a first eccentric cam (32), a groove is provided on the side of the first eccentric cam (32) facing the transmission member (31), and a second eccentric cam (33) is provided in the groove. The eccentric groove (30) is formed between the first eccentric cam (32) and the second eccentric cam (33).
3. The pressing component for a kit according to claim 1, Characterized in that, The eccentric member includes a substrate (34), and the eccentric groove (30) is a spiral groove provided on the substrate (34), and the spiral groove is located on the side of the substrate (34) facing the transmission member (31).
4. The pressing component for a kit according to any one of claims 1 to 3, Characterized in that, The transmission member (31) includes a fixed section (310), the rolling section (311) is rotatably arranged on the fixed section (310), and the transmission member (31) is fixedly arranged on the pressing member (2) through the fixed section (310).
5. The pressing assembly for a kit according to claim 4, wherein, the fixed section (310) has a circular shaft, the rolling section (311) is a bearing, the inner ring of the bearing is in interference fit with the circular shaft, and the outer ring of the bearing is in rolling contact with the inner wall of the eccentric groove (30).
6. The pressing assembly for a kit according to claim 1, wherein, the pressing assembly further includes a base (4), the driving motor (1) is arranged on the base (4), and a guiding member (41) for restricting the moving direction of the pressing member (2) is arranged between the pressing member (2) and the base (4).
7. The pressing assembly for a kit according to claim 1, wherein, the upper pressing plate (20) is provided with a perforation (200) along a set direction, the connecting member (23) is arranged through the perforation (200), the limiting member is a flange (230) formed at one end of the connecting member (23), and a blocking portion (250) adapted to the flange (230) is arranged in the perforation (200), and the blocking portion (250) presses against the flange (230) under the action of the elastic member (24).
8. The pressing assembly for a kit according to claim 7, wherein, the connecting member (23) is columnar, a linear bearing (25) is sleeved outside the connecting member (23), the linear bearing (25) is fixedly connected with the upper pressing plate (20), and the linear bearing (25) has a blocking portion (250) extending into the perforation (200).
9. The pressing assembly for a kit according to claim 8, wherein, the elastic member (24) is a spring, and the spring is sleeved outside the linear bearing (25); the linear bearing (25) protrudes radially outward to form an annular protrusion (251), one end of the spring is arranged on the annular protrusion (251), and the other end of the spring is arranged on the lower pressing plate (21).
10. A detection instrument for a kit, comprising a housing (6), a bracket (7), an extraction and amplification assembly (8), an optoelectronic assembly (9), and the pressing assembly for a kit according to any one of claims 1 to 9, wherein, the bracket (7) is arranged inside the housing (6), and the extraction and amplification assembly (8), the optoelectronic assembly (9), and the pressing assembly are all arranged on the bracket (7).
Citation Information
Patent Citations
Automatic and integrated system for extracting, amplifying and detecting nucleic acids
CN107603859A