A elution device and method for an iodine-125 extraction device

Abstract

The present invention discloses a elution device and method for an iodine-125 extraction device, belonging to the technical field of preparation of radioactive isotopes. It includes: an elution frame and an installed elution assembly, and the installed elution assembly includes: an installed elution seat and two elution nozzles. An installed elution port for connecting and installing the iodine-125 extraction device is opened on the installed elution seat, and the two elution nozzles are respectively connected to the gas nozzles of the iodine-125 extraction device. The elution device for the iodine-125 extraction device provided by the present invention has an independent structure. During the production process, after the extraction device in the iodine-125 loop is removed, it is installed on the elution device, and the extraction device is quickly and simply eluted by injecting an alkali solution through the elution device to obtain a sodium iodide [125I] solution, thereby achieving efficient and rapid recovery of iodine in the loop. Compared with the traditional elution of iodine-125, this device greatly simplifies the operation process, reduces the cost, improves the work efficiency, and reduces the radiation exposure time of the staff.

Description

Technical Field

[0001] The present invention relates to the technical field of radioactive isotope preparation, and particularly relates to a elution device and method for an iodine-125 extraction device, and more particularly to a elution device and method for an iodine-125 extraction device suitable for the irradiation production of iodine-125 by a continuous circulation loop method. Background Art

[0002] Iodine-125 is an important medical radioactive nuclide (T 1 / 2 = 59.407 d). Due to its relatively long half-life, moderate energy, and small radiation damage to human tissues, it has been widely used in biomedicine, in vitro radioimmunoassay diagnosis, and brachytherapy for treating tumors. However, at present, the raw materials of iodine-125 in China have been completely dependent on imports for a long time.

[0003] In June 2021, the National Atomic Energy Agency jointly with 7 departments including the Ministry of Science and Technology officially issued the Medium- and Long-Term Development Plan for Medical Isotopes (2021-2035), requiring to gradually establish a stable and independent medical isotope supply guarantee system to meet the growing health needs of people and provide a strong guarantee for building a healthy country compatible with a socialist modern country. The "Plan" clearly requires to master the irradiation and purification technologies of iodine-125, etc. Therefore, carrying out the research and development of a new iodine-125 production process, breaking foreign monopolies, mastering the core key technologies, and realizing the localization of iodine-125 raw materials have great scientific and practical significance for promoting the development of the entire nuclear medicine industry chain and boosting the implementation of the "Healthy China" strategy.

[0004] At present, taking advantage of the reactor and supporting resources, the Nuclear Power Institute of China has completed a large number of experimental verifications and proposed a technical method and device for producing iodine-125 by continuous cycle irradiation. This method innovatively designs a quick-disconnectable iodine-125 extraction device in the loop device (this device is mainly used for selectively adsorbing iodine-125 generated in the loop. When the gas in the circulation loop passes through the extraction device, it is selectively captured). The extraction device can be quickly exchanged between the iodine-125 loop device and the elution device by simple plugging and unplugging, so as to achieve the rapid extraction and elution recovery of iodine-125 in the loop, and finally realize the continuous cycle production of iodine-125; that is, after the extraction device adsorbs iodine-125 to saturation in the iodine-125 loop, it is removed by a manipulator, transferred to a shielded glove box with an elution device through a shielding transportation device, and then installed in the elution device by a manipulator. Subsequently, an alkali solution is injected into the elution device through a circulation pump, and the iodine-125 captured in the extraction device can be eluted by simply eluting the extraction device, and finally a sodium iodide [iodine-125] solution product is obtained. In the traditional production process of iodine-125, the extraction and recovery involve steps such as the transfer of xenon-125 gas, the decay of xenon-125, liquid nitrogen freezing, target cylinder cutting, alkali solution elution, and extraction. The operation is troublesome and radioactive waste leakage is likely to occur. Summary of the Invention

[0005] The purpose of the present invention is to provide an elution device and method for an iodine-125 extraction device, so as to solve the problems that in the traditional production process of iodine-125, the extraction and recovery involve steps such as the transfer of xenon-125 gas, the decay of xenon-125, liquid nitrogen freezing, target cylinder cutting, alkali solution elution, and extraction, the operation is troublesome, and radioactive waste leakage is likely to occur.

[0006] The technical solution of the present invention to solve the above technical problems is as follows:

[0007] The present invention provides an elution device for an iodine-125 extraction device, including: an elution frame and an installed elution assembly. An elution panel is fixed at one end of the elution frame, and the installed elution assembly for connecting and eluting the iodine-125 extraction device is arranged on the elution panel;

[0008] The installed elution assembly includes: an installed elution seat and two elution nozzles. An installed elution port for connecting and installing the iodine-125 extraction device is opened on the installed elution seat, and the elution nozzles are arranged in the installed elution port;

[0009] The two elution nozzles are respectively connected to the air nozzles for the iodine-125 extraction device.

[0010] Further, in the elution device for the iodine-125 extraction device, the elution frame includes: a first rectangular frame and a second rectangular frame arranged vertically, the height of the second rectangular frame being greater than that of the first rectangular frame, the four end parts of the first rectangular frame being respectively connected to the second rectangular frame through horizontal bars, and the top of the first rectangular frame being further connected to the top of the second rectangular frame through diagonal bars correspondingly;

[0011] The elution panel is fixed on the second rectangular frame.

[0012] Further, in the elution device for the iodine-125 extraction device, end caps for protection are respectively provided at the connection positions of the diagonal bars and the elution panel.

[0013] Further, in the elution device for the iodine-125 extraction device, angle seats are installed at the connection positions of the horizontal bars and the first rectangular frame and at the connection positions of the horizontal bars and the second rectangular frame.

[0014] Further, in the elution device for the iodine-125 extraction device, counterweights are provided on the elution frame.

[0015] Further, in the elution device for the iodine-125 extraction device, a fixed lock plate is installed at one end of the installation elution seat away from the elution panel through a lock plate groove, both ends of the fixed lock plate are respectively connected with lock plate grooves adapted to the fixed lock plate, and the ends of the lock plate grooves away from the fixed lock plate are fixed on the installation elution seat.

[0016] Further, in the elution device for the iodine-125 extraction device, a positioning bolt is provided at the end of the installation elution seat close to the fixed lock plate.

[0017] Further, in the elution device for the iodine-125 extraction device, the included angle between the installation elution seat and the elution panel is 15 - 30°.

[0018] Further, in the elution device for the iodine-125 extraction device, the inner diameter of the elution nozzle is 1 - 2 cm, and the wall thickness is 0.5 - 1 cm.

[0019] The present invention also provides an elution method for the iodine-125 extraction device. Based on the above elution device for the iodine-125 extraction device, the method includes the following steps:

[0020] Install the installation elution assembly on the elution frame, and connect the elution nozzles to the elution solution respectively;

[0021] Install the extraction device for iodine-125 on the elution seat and fix it. Then, introduce the elution liquid into the extraction device through the elution nozzle to elute and recover the adsorbed iodine-125.

[0022] The present invention has the following beneficial effects:

[0023] The elution device for the iodine-125 extraction device provided by the present invention has an independent structure. During the production process, after removing the extraction device in the iodine-125 circuit, it is installed on the elution device. By injecting alkali solution into the extraction device through the elution device for rapid and simple elution, sodium iodide [125I] solution can be obtained, thereby achieving efficient and rapid recovery of iodine in the circuit. Compared with the traditional elution of iodine-125, this device greatly simplifies the operation process, reduces costs, improves work efficiency, and reduces the radiation exposure time of the staff.

[0024] The elution device for the iodine-125 extraction device provided by the present invention is one of the very important key devices in the process of iodine-125 irradiation production and recovery, laying a solid foundation for the efficient and rapid recovery of iodine-125 during the irradiation production of iodine-125 by the continuous circulation loop method. The alkali solution in the elution device can be recycled, reducing the consumption of the elution solution. Compared with the traditional method, it avoids using a large amount of alkali solution to soak the decay device, greatly reducing the use of radioactive waste liquid and saving the waste disposal cost.

[0025] The elution device for the iodine-125 extraction device provided by the present invention is installed in the shielding glove box. During the elution process, the operation can be completed only outside the box to achieve the elution of the extraction device and the recovery of iodine-125, greatly reducing the operation time of the staff in the radiation area and reducing the radiation damage to the staff. Description of the Drawings

[0026] The drawings described herein are used to provide a further understanding of the embodiments of the present invention, form a part of this application, and do not limit the embodiments of the present invention. In the drawings:

[0027] Figure 1 It is a front view structural schematic diagram of the elution device for the iodine-125 extraction device of the present invention;

[0028] Figure 2 It is a side view structural schematic diagram of the elution device for the iodine-125 extraction device of the present invention;

[0029] Figure 3 It is a top view structural schematic diagram of the elution device for the iodine-125 extraction device of the present invention.

[0030] Marks in the drawings and corresponding component names:

[0031] In the figure: 100 - rinsing frame, 101 - first rectangular frame, 102 - second rectangular frame, 103 - horizontal rod, 104 - diagonal rod, 105 - end cap, 106 - corner seat, 110 - rinsing panel, 120 - counterweight, 200 - installation rinsing assembly, 210 - installation rinsing seat, 220 - rinsing nozzle, 230 - installation rinsing port, 240 - fixing lock plate, 250 - lock plate groove, 260 - positioning bolt. Detailed implementation mode

[0032] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. Usually, the components of the embodiments of the present invention described and illustrated in the accompanying drawings here can be arranged and designed in various different configurations.

[0033] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed present invention, but merely represents selected embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts fall within the scope of protection of the present invention.

[0034] Embodiment 1

[0035] Please refer to Figure 1 and Figure 2 , this embodiment provides a rinsing device for an iodine-125 extraction device, including: a rinsing frame 100 and an installation rinsing assembly 200. The installation rinsing assembly 200 is installed and fixed on the rinsing frame 100. The rinsing frame 100 serves a supporting and installation role. The installation rinsing assembly 200 is used to install and connect to the iodine-125 extraction device and rinse the iodine-125 extraction device. A rinsing panel 110 is fixed at one end of the rinsing frame 100. The installation rinsing assembly 200 is installed on the rinsing panel 110, and the rinsing panel 110 facilitates the installation operation of the installation rinsing assembly 200. In this embodiment, the included angle between the installation rinsing seat 210 and the rinsing panel 110 is 15 - 30°, and the installation rinsing assembly 200 is integrally inclined downward, which is beneficial for the water spraying of the rinsing nozzle 220.

[0036] The installation and elution assembly 200 includes: an installation and elution base 210 and two elution nozzles 220. An installation and elution port 230 is provided on the installation and elution base 210, which is adapted to the elution connection of the iodine-125 extraction device and is used to connect to the installation and elution port 230 of the iodine-125 extraction device. The elution nozzles 220 are arranged in the installation and elution port 230, and the two elution nozzles 220 are respectively connected to the gas nozzles of the iodine-125 extraction device. The elution liquid enters the extraction device through the elution nozzles 220 to elute the iodine-125 adsorbent, so as to recover the iodine-125 product. The elution nozzles 220 are connected to a peristaltic pump through a connecting pipe. The peristaltic pump is connected with an elution solution, and the elution solution is mostly an alkaline solution. The peristaltic pump elutes the extraction device through the elution nozzles 220 with the elution solution. In this embodiment, the inner diameter of the elution nozzles 220 is 1-2 cm, and the wall thickness is 0.5-1 cm to obtain a better spraying effect.

[0037] During the actual use process, the elution device of this embodiment is installed in a shielded glove box. During the elution process, only the control interface of the peristaltic pump outside the box needs to be simply controlled to complete the elution of the device and the recovery of iodine-125, greatly reducing the operation time of the staff in the radiation area and reducing the radiation damage to the staff.

[0038] In a feasible implementation, the elution frame 100 includes: a first rectangular frame 101 and a second rectangular frame 102. The first rectangular frame 101 and the second rectangular frame 102 are arranged vertically. The first rectangular frame 101 and the second rectangular frame 102 are both formed by fixing 4 straight rods, and the enclosed rectangular shape can specifically be a rectangle or a square, and the specific shape can be selected according to the actual situation. Horizontal rods 103 are respectively installed at the four end parts of the first rectangular frame 101, and the other ends of the horizontal rods 103 are correspondingly connected to the second rectangular frame 102. In this way, the first rectangular frame 101 is fixed on the second rectangular frame 102 and forms a horizontal plane, which is used to be more easily installed and fixed on the ground or other planes. Since the height of the second rectangular frame 102 is greater than the height of the first rectangular frame 101, inclined rods 104 are respectively installed at the four end parts of the top of the first rectangular frame 101, and the other ends of the inclined rods 104 are correspondingly connected to the top of the second rectangular frame 102. In this way, a stable triangular structure is formed by the inclined rods 104, the horizontal rods 103 and some straight rods of the second rectangular frame 102, which is beneficial to the stability of installing the elution assembly 200.

[0039] The rinsing panel 110 is installed on the rinsing frame 100 and is specifically fixed on the second rectangular frame of the rinsing frame 100. The rinsing panel 110 is fixed on the four straight rods of the second rectangular frame 102 through fasteners. The fasteners can be bolts, screws, etc. In this embodiment, the fasteners adopt socket head cap screws to fix the rinsing panel 110 on the rinsing frame 100. Multiple socket head cap screws are respectively fixed on both sides of the second rectangular frame 102 in the vertical direction.

[0040] In a feasible solution, end caps 105 are respectively provided at the connection points of the inclined rods 104 and the second rectangular frame 102, that is, end caps 105 are arranged on both sides of the top of the second rectangular frame 102, which can wrap and cover the connection points of the inclined rods 104 and the second rectangular frame 102, playing a protective role to avoid being cut by sharp corners.

[0041] In a feasible implementation scheme, angle seats 106 are installed at the connection points of the horizontal rods 103 and the first rectangular frame 101, that is, the angle seats 106 are installed on the side of the first rectangular frame 101 in the vertical direction facing the second rectangular frame 102. Angle seats 106 are installed between the corresponding horizontal rods 103 connected to the first rectangular frame 101. The angle seats 106 are fixed through fasteners. The fasteners can be bolts, screws, etc. In this embodiment, the fasteners adopt socket head cap screws with round heads, and also adopt matching reverse-mounted spring nuts and C-class flat washers to fix the angle seats 106 to ensure the overall stability of the rinsing frame 100. Angle seats 106 are installed at the connection points of the horizontal rods 103 and the second rectangular frame 102, that is, the angle seats 106 are installed on the side of the second rectangular frame 102 in the vertical direction facing the first rectangular frame 101. Angle seats 106 are installed between the corresponding horizontal rods 103 connected to the second rectangular frame 102. The angle seats 106 are fixed through fasteners. The fasteners can be bolts, screws, etc. In this embodiment, the fasteners adopt socket head cap screws with round heads, and also adopt matching reverse-mounted spring nuts and C-class flat washers to fix the angle seats 106 to ensure the overall stability of the rinsing frame 100.

[0042] In a feasible implementation scheme, a counterweight 120 is provided on the rinsing frame 100. Specifically, the counterweight 120 is placed behind the rinsing panel 110 and placed on the first rectangular frame 101 or the second rectangular frame 102. The counterweight 120 can also be suspended between the first rectangular frame 101 and the second rectangular frame 102. The counterweight 120 serves the purpose of increasing the weight, ensuring the stability of the rinsing device during the rapid plugging and unplugging process of the extraction device, and avoiding radioactive liquid spilling caused by the detachment of the rinsing pipeline, resulting in radioactive contamination.

[0043] In a feasible implementation scheme, please refer to Figure 1 、 Figure 2 and Figure 3, a fixing lock plate 240 is installed at one end of the installation rinsing seat 210 away from the rinsing panel 110. Both ends of the fixing lock plate 240 are respectively connected with lock plate grooves 250 that are adapted to the fixing lock plate 240. One end of the lock plate groove 250 away from the fixing lock plate 240 is fixed on the installation rinsing seat 210. After the extraction device is fixed on the installation rinsing seat 210, the extraction device is fixed by the combination of the fixing lock plate 240 and the lock plate groove 250, which can prevent the leakage of rinsing liquid during the rinsing process.

[0044] In a feasible implementation, a positioning bolt 260 is further provided on the installation rinsing seat 210. The positioning bolt 260 is arranged at one end of the installation rinsing seat 210 close to the fixing lock plate 240, and the extraction device to be installed is positioned and installed through the positioning bolt 260.

[0045] Both the rinsing frame 100 and the installation rinsing assembly 200 in this embodiment are detachable. The component materials of the rinsing frame 100 and the installation rinsing assembly 200 are both made of 301 or 304 stainless steel, with high hardness, corrosion resistance, and long service life. The total mass of the rinsing frame 100 and the installation rinsing assembly 200 is controlled not to exceed 10 kg, which is easy to disassemble and install, has stronger practicability, and is convenient to be transferred to different places for use.

[0046] Embodiment 2

[0047] Please refer to Figure 1 and Figure 2 , this embodiment provides a rinsing method for an iodine-125 extraction device. Based on the rinsing device for an iodine-125 extraction device in Embodiment 1, it includes the following steps:

[0048] Install the installation rinsing assembly on the rinsing frame, and connect the rinsing nozzles to the rinsing solution respectively;

[0049] Install and fix the iodine-125 extraction device on the installation rinsing seat, and let the rinsing liquid enter the extraction device through the rinsing nozzles to rinse and recover the adsorbed iodine-125.

[0050] Specifically, after assembling the rinsing frame in sequence, install the installation rinsing seat of the installation rinsing assembly on the rinsing frame, install the extraction device removed from the extraction circuit on the installation rinsing seat, and fix the lock plate in the installation rinsing seat.

[0051] Connect the tubes for the inlet and outlet of the peristaltic pump to the two rinsing nozzles in the installation rinsing assembly respectively. The inlet tube of the peristaltic pump is connected to the alkaline solution for rinsing and recovery (this alkaline solution can elute and recover iodine-125, and the volume and concentration of this alkaline solution can be adjusted according to actual situations), and one rinsing nozzle is connected to a recovery bottle.

[0052] Start the peristaltic pump and control the flow rate of the peristaltic pump at 2 - 5 r / min. Let the lye enter the extraction device through the rinsing nozzle in the rinsing device at a constant flow rate, so as to elute and recover the adsorbed iodine-125 in the extraction device until the recovery is complete.

[0053] The specific embodiments described above have further elaborated on the purpose, technical solutions, and beneficial effects of the present invention. It should be understood that the above are only specific embodiments of the present invention and are not used to limit the protection scope of the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A elution device for an iodine-125 extraction device, characterized in that, Including: A rinsing frame (100) and a mounted rinsing assembly (200). A rinsing panel (110) is fixed at one end of the rinsing frame (100). The mounted rinsing assembly (200) for rinsing and connected to an iodine-125 extraction device is provided on the rinsing panel (110); the mounted rinsing assembly (200) includes a mounted rinsing base (210) and two rinsing nozzles (220). A mounted rinsing port (230) for connecting and mounting an iodine-125 extraction device is provided on the mounted rinsing base (210), and the rinsing nozzles (220) are arranged in the mounted rinsing port (230); the two rinsing nozzles (220) are respectively connected to the gas nozzles of the iodine-125 extraction device. A fixed lock plate (240) is mounted at one end of the mounted rinsing base (210) away from the rinsing panel (110) through a lock plate groove (250). Both ends of the fixed lock plate (240) are respectively connected to lock plate grooves (250) that are adapted to the fixed lock plate (240). One end of the lock plate groove (250) away from the fixed lock plate (240) is fixed on the mounted rinsing base (210). The rinsing device for the iodine-125 extraction device is an independent structure.

2. The elution device for an iodine-125 extraction device according to claim 1, characterized in that, The rinsing frame (100) includes a vertically arranged first rectangular frame (101) and a second rectangular frame (102). The height of the second rectangular frame (102) is greater than the height of the first rectangular frame (101). The four peripheral ends of the first rectangular frame (101) are respectively connected to the second rectangular frame (102) through horizontal rods (103), and the four peripheries of the top of the first rectangular frame (101) are also correspondingly connected to the top of the second rectangular frame (102) through inclined rods (104); the rinsing panel (110) is fixed on the second rectangular frame (102).

3. The elution device for the iodine-125 extraction device according to claim 2, characterized in that, End caps (105) for protection are respectively provided at the connection positions of the inclined rods (104) and the second rectangular frame (102).

4. The elution device for an iodine-125 extraction device according to claim 2, wherein Corner seats (106) are installed at the connection positions of the horizontal rods (103) and the first rectangular frame (101) and at the connection positions of the horizontal rods (103) and the second rectangular frame (102).

5. The elution device for the iodine-125 extraction device according to claim 1 or 2, characterized in that, A counterweight block (120) is provided on the rinsing frame (100).

6. The elution device for an iodine-125 extraction device according to claim 1, wherein A positioning bolt (260) is provided at the end of the mounted rinsing base (210) close to the fixed lock plate (240).

7. The elution device for the iodine-125 extraction device according to claim 1, characterized in that, The included angle between the mounted rinsing base (210) and the rinsing panel (100) is 15 - 30°.

8. The elution device for an iodine-125 extraction device according to claim 1, wherein, The inner diameter of the rinsing nozzle (220) is 1 - 2 cm, and the wall thickness is 0.5 - 1 cm.

9. A elution method for an iodine-125 extraction device, characterized in that, Based on the rinsing device for the iodine-125 extraction device according to any one of claims 1 - 8, the following steps are included: mounting the mounted rinsing assembly on the rinsing frame, connecting the rinsing nozzles to the rinsing solution respectively; mounting and fixing the iodine-125 extraction device on the mounted rinsing base, and allowing the rinsing liquid to enter the extraction device through the rinsing nozzles to rinse and recover the adsorbed iodine-125.

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