A biochip detection system

Abstract

The application provides a biochip detection system. The biochip detection system comprises a distribution device, a cleaning device and a detection device. The distribution device is a disc, and a plurality of distribution chip slots are arranged on the disc and point to the center of the disc. The distribution chip slots are through along the two ends of the radius direction of the disc. The cleaning device is provided with a cleaning chip slot, and the cleaning device is located in the inner ring of the disc and is uniformly distributed. The cleaning chip slot is arranged opposite to any distribution chip slot. The detection device is located at the center of the distribution device, and the detection device can rotate. A first hatch is arranged on one side of the detection device. The rotation of the detection device aligns the first hatch with any cleaning chip slot. Compared with the related art, the biochip detection system provided by the application has compact layout and saves waiting time.

Description

Technical Field

[0001] This invention relates to the field of biochip detection technology, and in particular to a biochip detection system. Background Technology

[0002] Biochip detection technology, including protein chip detection technology and gene chip detection technology, is being used more and more widely in scientific research, medicine and health, forensic identification, environmental monitoring and other fields.

[0003] Since microfluidic chips are mostly made of glass, quartz, and organic materials, which have good optical properties, combining microfluidics with optical devices such as light sources, photodetectors, optical fibers, and lenses, and using optical detection methods, has become an important trend in microfluidic analysis technology in recent years.

[0004] Biochip testing generally includes: a wafer loading station for storing and inputting the chip to be tested, a pre-processing station for chip pretreatment, a magnetic bead adding station for adding samples, mixing and adding magnetic beads to the chip, a cleaning station for cleaning the chip, and a testing station.

[0005] Currently, existing biochip detection systems mainly fall into two categories: straight-through layout and disc layout. The straight-through layout arranges all stations (such as chip entry, pretreatment, adding magnetic beads, cleaning, and detection) in a straight line. This method occupies a large space and the detection cycle cannot be well planned, resulting in a long waiting time for detection and low detection efficiency.

[0006] A disc-shaped layout, such as the microfluidic biochip luminescence detection workstation disclosed in patent publication number CN107238716A, involves multiple chips entering the disc at once through a microfluidic biochip cartridge in / out transfer module. These chips simultaneously undergo reaction, liquid addition, and detection within the disc. After all chips have completed detection, they are output from the microfluidic biochip cartridge in / out transfer module, enabling simultaneous detection of multiple samples. However, this layout cannot achieve streamlined operation, and the chip inlet and outlet are on the same module, which is prone to interference. Therefore, new chips can only be added after the batch of chips in the disc has completed its detection, resulting in a long waiting time for new chips.

[0007] In addition, the chip involved in this case is a biochip used in the medical industry for in vitro diagnostics. Summary of the Invention

[0008] The purpose of this invention is to provide a biochip detection system with a compact layout and reduced waiting time.

[0009] The technical solution of the present invention is as follows: A biochip detection system includes a delivery device, a cleaning device, and a detection device. The delivery device is a rotatable disc with multiple delivery chip slots pointing towards the center, the delivery chip slots being continuous at both ends along the radial direction of the disc. The cleaning device has cleaning chip slots, which are located on the inner circle of the disc and are evenly distributed, with each cleaning chip slot facing any one of the delivery chip slots. The detection device is located at the center of the delivery device and is rotatable. A first door is provided on one side of the detection device, and the rotation of the detection device aligns the first door with any of the cleaning chip slots.

[0010] In the above scheme, the delivery device is designed as a disc and is well integrated with other workstations to achieve an overall assembly line layout. The testing and cleaning devices are arranged near the disc. The overall structure is compact and small in size, which is conducive to the turnover and circulation of biochips. It also shortens the distance that biochips travel in the testing system, ensures that the chip inlet can always receive chips, and ensures that the chip discarding outlet does not interfere with the chip inlet after testing. This enables uninterrupted operation and reduces waiting time.

[0011] Furthermore, the delivery device is designed in the shape of a disc, with a chip delivery slot through the two ends of the disc. This allows the disc-structured delivery device to deliver chips to devices located at different openings for corresponding processing and testing. Moreover, the chips do not interfere with each other during the delivery process, enabling continuous operation.

[0012] Preferably, the biochip detection system further includes a chip loading chamber and a processing device. The chip loading chamber forms a cavity in the X direction that can accommodate multiple biochips, and the cavity has an outlet on one side in the Y direction. The processing device has a channel for placing biochips, and the channel is connected to the outlet and a chip delivery slot.

[0013] The material storage and feeding are arranged in the X direction, while the self-feeding bin, processing device and delivery device are designed for conveying in the Y direction. On the one hand, this achieves a compact structural layout, and on the other hand, it avoids interference.

[0014] Preferably, the chip inlet includes a first baffle, a second baffle, a first base plate, a push plate, a stop block, and a reader for identifying barcodes on the biochip. The first and second baffles are spaced apart in the Y direction, and the first base plate connects the first and second baffles. The inner surfaces of the first and second baffles and the upper surface of the first base plate form the cavity. The push plate is disposed within the cavity and extends and retracts in the X direction. The stop block is positioned opposite the push plate within the cavity. The outlet is disposed on the second baffle, and the inner surface of the stop block forms one side of the outlet. The reader is adjacent to the stop block and directly opposite the cavity.

[0015] The chip loading compartment is designed to accommodate multiple chips for testing at once, and can be loaded continuously, making it suitable for continuous testing without interruption.

[0016] Preferably, the second baffle is positioned adjacent to the delivery device, and the height of the second baffle in the Z direction is lower than that of the first baffle in the Z direction. Furthermore, the height difference between the two baffles matches the height difference between the protrusions on both sides of the chip. This height difference design achieves a foolproof effect, preventing the chip from being placed backwards.

[0017] Preferably, the processing device extends along the Y direction, and a plurality of sample dispensing devices are provided above the processing device, the sample dispensing devices extending vertically in the Z direction; a recognizer and a laser are provided on the side of the processing device, the recognizer and the laser are both facing the processing device in the X direction, and the number of the recognizer corresponds to the number of sample dispensing devices.

[0018] The processing device adopts a straight-through layout, which can perform ultrasonic mixing, laser drilling, barcode and chip position recognition by openMV camera, vibration mixing and multi-reagent addition on the chips to be tested one by one, providing a basis for streamlined operation.

[0019] Preferably, the processing device includes a first side plate, a second side plate, and a second bottom plate. The first side plate and the second side plate are spaced apart in the X direction. The second bottom plate connects the first side plate and the second side plate. The inner surfaces of the first side plate and the second side plate and the upper surface of the second bottom plate form a channel for placing a biochip. The identifier and the laser are positioned opposite the channel.

[0020] The layout length of the processing device is perpendicular to the layout length of the wafer loading compartment, which enables a more compact storage structure in the wafer loading compartment and allows for the uninterrupted delivery of one chip at a time to the processing device without interfering with existing chips in the processing device.

[0021] To enable effective identification, a QR code is affixed to each of the delivery chip slots, and a reader for identifying the QR code is located directly above the connection point between the processing device and the delivery device.

[0022] Preferably, the biochip detection system further includes a magnetic bead device, which includes a magnetic bead chip slot, the magnetic bead chip slot being positioned opposite the delivery chip slot, and the magnetic bead chip slot and the delivery chip slot having the same height in the Z direction; an ultrasonic probe and a reader are provided on the side of the magnetic bead chip slot, and the ultrasonic probe and the reader are positioned opposite the delivery chip slot; a sample application device that extends vertically in the Z direction is provided above the magnetic bead chip slot.

[0023] Preferably, the cleaning device includes a cleaning chip slot, a vibration motor, and a magnet. The cleaning chip slot is positioned opposite the delivery chip slot, and the cleaning chip slot and the delivery chip slot are at the same height in the Z direction. The vibration motor is located at the bottom of the cleaning chip slot, and the magnet is located on the side wall of the cleaning chip slot. An identifier is provided beside the cleaning chip slot, and a vertically telescopic sample dispensing device is provided above the cleaning chip slot, with the identifier positioned opposite the cleaning chip slot.

[0024] Preferably, the detection device is a sealed cavity formed by a detection top plate, a detection bottom plate and four detection side plates. One of the detection side plates is provided with a feed inlet, and a first door is provided on the detection side plate and can open or close the feed inlet. The detection bottom plate is provided with a discharge port, and a second door is provided on the detection bottom plate and can open or close the discharge port. The feed inlet is positioned directly opposite the cleaning device.

[0025] The detection device can not only perform detection, but also discard the chips after detection, thus automating the entire detection process for each chip.

[0026] Preferably, the detection device further includes a detection chip slot, which is rotatably mounted in the sealed cavity, and one end of the detection chip slot is connected to the feed port; a support block is provided on the detection side plate with the feed port, one end of the support block protruding from the outside of the detection side plate, and the other end connecting to the detection chip slot from the feed port.

[0027] In the specific technical solution, the support block is flared to facilitate chip entry and serves as a guide; and the chip detection slot is a rotatable structure, which can both place the chip for easy detection and rotate to tilt and discard it.

[0028] Preferably, the detection device extends vertically through the delivery device, and a second door is provided at the bottom of the detection device.

[0029] Compared with related technologies, the beneficial effects of the present invention are as follows: using a coaxial rotating disk and arranging the detection device at the center of the disk results in a compact overall structure and small size, which is conducive to the turnover and circulation of biochips; it shortens the distance the biochip travels in the detection system and reduces the waiting time between different workstations; it allows for the arrangement of an appropriate number of workstations according to the processing time of each workstation, which is conducive to achieving high throughput requirements. Attached Figure Description

[0030] Figure 1 A three-dimensional structural schematic diagram of the biochip detection system provided by the present invention;

[0031] Figure 2 for Figure 1 A top-down view;

[0032] Figure 3 for Figure 1 A frontal view diagram;

[0033] Figure 4 for Figure 3 A schematic diagram of the film loading compartment and processing device in the film;

[0034] Figure 5 for Figure 1 A three-dimensional view of the detection device from below;

[0035] Figure 6 This is a schematic diagram of the detection method of the biochip detection system provided by the present invention. Detailed Implementation

[0036] The present invention will now be described in detail with reference to the accompanying drawings and embodiments. It should be noted that, unless otherwise specified, the embodiments and features described herein can be combined with each other. For ease of description, the terms "upper," "lower," "left," and "right" used below only indicate that they correspond to the upper, lower, left, and right directions in the accompanying drawings and do not limit the structure.

[0037] like Figure 6 As shown, the biochip detection system provided in this embodiment includes a wafer loading chamber 1-1, a processing device 1-2, a delivery device 1-3, a magnetic bead adding device 1-4, a cleaning device 1-5, and a detection device 1-6. The wafer loading chamber 1-1 forms a cavity in the X direction capable of accommodating multiple biochips, and the cavity has an outlet 31 on one side in the Y direction (e.g., ...). Figure 2 (As shown).

[0038] like Figures 1-3As shown, the chip loading chamber 1-1 includes a first baffle 3, a second baffle 9, a first base plate 4, a flat push plate 2, a stop block 7, and an identifier 11 for recognizing barcodes on the biochip. The first baffle 3 and the second baffle 9 are spaced apart in the Y direction. The first base plate 4 connects the first baffle 3 and the second baffle 9. The inner surfaces of the first baffle 3 and the second baffle 9 and the upper surface of the first base plate 4 form the cavity. The spacing between the first baffle 3 and the second baffle 9 is the same as the width of the chip 1. The cavity can accommodate multiple chips 1, allowing multiple chips 1 to be placed side by side in the X direction.

[0039] The second baffle 9 is disposed adjacent to the delivery device 1-3, and the height of the second baffle 9 in the Z direction is lower than the height of the first baffle 3 in the Z direction (e.g., Figure 4 (As shown). The height difference prevents users from placing the chips upside down, achieving a foolproof effect. The length of the side baffles in the X direction can be adjusted to accommodate the required number of chips placed at once, depending on actual usage needs.

[0040] The push plate 2 is disposed within the cavity and extends and retracts along the X direction. The stop block 7 is positioned opposite the push plate 2 within the cavity. The outlet 31 is disposed on the second baffle 9, and the inner side of the stop block 7 forms one side of the outlet 31. The identifier 11 is positioned adjacent to the stop block 7 and directly opposite the cavity.

[0041] The push plate 2 continuously applies a pushing force to the stop 7. When the chip 1 is pushed to the position where it is blocked by the stop 7, the recognizer 11 identifies the chip 1 and records the QR code information on the chip 1. Then, the chip 1 is pushed horizontally from the outlet 31 along the Y direction into the processing device 1.

[0042] like Figure 6 As shown, the delivery device 1-3 is a rotatable disc with multiple delivery chip slots 32 pointing towards the center. The two ends of the delivery chip slots 32 are through openings along the radial direction of the disc. The processing device 1-2 is connected to an opening of one of the delivery chip slots 32 away from the center and the outlet 31.

[0043] like Figures 1-3 As shown, the processing device 1-2 extends along the Y direction and is arranged in a straight-through manner with multiple workstations. The processing device 1-2 includes a first side plate 24, a second side plate 23, and a second base plate 8. The first side plate 24 and the second side plate 23 are spaced apart in the X direction, and the second base plate 8 connects the first side plate 24 and the second side plate 23. The inner surfaces of the first side plate 24 and the second side plate 23, and the upper surface of the second base plate 8 form a channel for placing a biochip. The channel is flush with the position of the chip being pushed in, and the height in the Z direction is consistent (e.g., ...). Figure 4 As shown), the chip 1, which is pushed out of the chip inlet 1-1, can enter the channel. Multiple sample dispensing devices 6 are located above the processing device 1-2, and these devices extend and retract vertically in the Z direction. The sample dispensing devices 6 are vertically downwards, directly facing the center of the plunger of the chip 1, and can dispense various reagents by pressing down on the plunger inside the chip.

[0044] A recognizer 11 and a laser 5 are provided on the side of the processing device 1-2. Both the recognizer 11 and the laser 5 are positioned in the X direction directly opposite the channel of the processing device 1-2. The number of recognizers 11 corresponds to the number of sample application devices 6. Each functional component is installed directly opposite the position on the chip to be used, and the first side plate 24 and the second side plate 23 need to be appropriately provided with clearances to prevent interference with the beams of the functional components.

[0045] like Figure 6 , Figure 3 , Figure 4 As shown, a third base plate 10 is provided at the bottom of the film loading chamber 1-1 and the processing device 1-2, so that the film loading chamber 1-1 and the processing device 1-2 form a closed integral structure, and the functional components are installed on it.

[0046] like Figure 3 As shown, the chip delivery slot 32 is at the same height as the channel in the Z direction.

[0047] like Figure 6 , Figure 1 , Figure 2 As shown, each of the delivery chip slots 32 has a QR code affixed to it. A reader 11 for recognizing the QR code is located directly above the connection point between the processing device 1-2 and the delivery device 1-3. The reader 11 is used to determine the absolute position of the disk and whether a chip is present in each delivery chip slot 32 and the state of the chip. The width of each delivery chip slot 32 is the same as the width of the chip 1. The channel of the processing device 1-2 points to the center of the disk of the delivery device 1-3, and their heights are consistent in the Z direction.

[0048] After the processing device 1-2 completes various actions, the chip 1 enters one of the chip delivery slots 32 of the delivery device 1-3. The disk rotates on a fixed axis to rotate the chip 1 and offset it from the processing device 1-2, so that other empty chip delivery slots 32 are aligned with the channel of the processing device 1-2, and then the next chip 1 is delivered, and so on.

[0049] like Figure 6 The magnetic bead device 1-4 is located on the side of the delivery device 1-3 and corresponds to the opening position of one of the delivery chip slots 32 away from the center.

[0050] like Figures 1-3 As shown, the magnetic bead adding device 1-4 includes a magnetic bead chip slot 13. The magnetic bead chip slot 13 is a C-shaped slot with one end open (the end facing the disk), directly opposite the delivery chip slot 32. The magnetic bead chip slot 13 and the delivery chip slot 32 are at the same height in the Z direction to ensure that the chip 1 on the disk can enter the magnetic bead chip slot 13 and return from the magnetic bead chip slot 13 to the delivery chip slot 32. The displacement of the chip 1 can be achieved by a motor and a push rod, and the positioning is detected by a corresponding sensor. The same applies below.

[0051] An ultrasonic probe 12 and a detector 11 are provided on the side of the magnetic bead chip slot 13, and the ultrasonic probe 12 and the detector 11 are positioned directly opposite the delivery chip slot 32. A clearance area needs to be provided on the side wall of the magnetic bead chip slot 13 to prevent interference with the sensing beams of the ultrasonic probe 12 and the detector 11.

[0052] Above the magnetic bead chip slot 13 is a sample dispensing device 6 that extends vertically in the Z direction. When the sample dispensing device 6 is vertically downward, it is directly opposite the center of the plunger of the chip 1, and various reagents can be dispensed by pressing down the plunger of the chip.

[0053] The specific number and position of the magnetic bead chip slots 13 are not limited and can be determined based on the time the chip 1 stays in this device and the overall system cycle time. The position of the magnetic bead chip slots 13 only needs to be aligned with the center of the delivery device and not interfere with other devices.

[0054] like Figure 6 As shown, the detection device 1-6 is located at the center of the delivery device 1-3 and vertically penetrates the delivery device 1-3. The detection device 1-6 is rotatable, and its rotation axis is vertically arranged. Multiple cleaning devices 1-5 are evenly distributed within the inner circle of the disc of the delivery device 1-3, specifically located between the delivery device 1-3 and the detection device 1-6.

[0055] like Figure 1 , Figure 5 As shown, the detection device 1-6 is a sealed cavity formed by a top detection plate 17, a bottom detection plate 20, and four side detection plates 16, 21, 29, and 30. One of the side detection plates 21 has a feed inlet 33 and a first hatch 18, which can open or close the feed inlet 33. The bottom detection plate 20 has a discharge outlet 34 and a second hatch 19, which can open or close the discharge outlet 34. The feed inlet 33 is positioned directly opposite the cleaning device 1-5. Figure 3As shown, the detection device extends below the disc of the delivery device.

[0056] like Figure 6 , Figure 5 As shown, the detection device 1-6 also includes a detection chip slot 28, which is rotatably mounted in the sealed cavity, and one end of the detection chip slot 28 is connected to the feed port 33. A support block 22 is provided on the detection side plate with the feed port 33. One end of the support block 22 protrudes from the outside of the detection side plate, and the other end is connected to the detection chip slot 28 from the feed port 33. The rotation of the detection chip slot 28 is as follows: initially, the detection chip slot 28 faces upwards so that the chip can be placed inside; after detection is completed, the detection chip slot 28 rotates 180° downwards, causing the chip to tip over under gravity and fall through the opened second door 19 into the collection bucket (not shown) below, completing the disposal.

[0057] The support block 2 is a flared groove used to guide the chip 1 from the cleaning device 1-5 into the detection device 1-6. The first hatch 18 and the second hatch 19 both move in parallel, ensuring the sealing of the cavity when closed.

[0058] like Figure 6 As shown, multiple cleaning devices 1-5 are arranged along the circumference of the disc, and each cleaning device 1-5 is connected to an opening near the center of a certain chip delivery slot 32 and a first door 18.

[0059] like Figure 1 , Figure 2 As shown, the cleaning device includes a cleaning chip slot 14, a vibration motor 26, and a magnet 27. The cleaning chip slot 14 is a C-shaped slot with both ends open, and has the same structure as the delivery chip slot 14. The cleaning chip slot 14 is positioned directly opposite the delivery chip slot 32, and the cleaning chip slot 14 and the delivery chip slot 32 have the same height in the Z direction to ensure that the chip 1 on the delivery device can enter the cleaning chip slot 14.

[0060] The vibration motor 26 is located at the bottom of the chip cleaning tank 14, specifically below the chip reaction cup. A clearance is required at the bottom of the chip cleaning tank 14 where the vibration occurs. The magnet 27 is located on the side wall of the chip cleaning tank 14. An identifier 11 is located beside the chip cleaning tank 14, and a vertically retractable sample dispensing device 6 is located above the chip cleaning tank 14. The identifier 11 is positioned directly opposite the chip cleaning tank 14.

[0061] Similarly, the sidewall of the cleaning chip groove 14 is provided with a clearance to prevent interference.

[0062] The detection device 1-6 can rotate along the Z-direction rotation axis to align the support block 2 with the cleaning chip slot 14 of the cleaning device 1-5.

[0063] All of the above-mentioned identifiers 11 use openMV cameras, and all of the sampling devices 6 are driven by linear motors.

[0064] like Figure 6 As shown, the present invention also provides a biochip detection method, which uses the above-described biochip detection system and includes:

[0065] ① The user places the chip with the test sample into the cavity of chip compartment 1-1 and places multiple chips at once; because the heights of the baffles 3 and 9 on both sides of chip compartment 1-1 are different, the chips cannot be placed on the reverse side.

[0066] ② The detection system is started. The flat push plate 2 is pushed towards the stop block 7, so that the first chip is displaced in the Y direction and then moves laterally from the outlet 31 into the channel of the processing device 1-2 in the X direction. The recognizer 11 facing the channel records the QR code information of the chip.

[0067] ③ The chip moves within the processing device 1-2, pausing once for each chip width of movement. The identifier 11, the sample dispensing device 6, and the laser 5 on both sides of the channel perform corresponding actions, including ultrasonic mixing, laser drilling, openMV camera recognition of barcode and chip position, vibration mixing, and dispensing of various reagents, etc.

[0068] ④ The delivery device 1-3 rotates so that the empty delivery chip slot 32 on the disc is aligned with the channel of the processing device 1-2, so that the chip can enter the delivery chip slot 32.

[0069] ⑤ The delivery device 1-3 rotates so that the chip delivery slot 32 containing the chip is aligned with the magnetic bead chip slot 13 of the magnetic bead adding device 1-4;

[0070] ⑥ The chip is inserted into the magnetic bead chip slot 13, where the magnetic bead device 1-4 performs ultrasonic mixing, the identifier 11 identifies the barcode, and the sample dispensing device 6 adds various reagents. Then the chip returns to the chip dispensing slot 32 of the dispensing device 1-3.

[0071] ⑦ The delivery device 1-3 rotates to align the chip in the delivery chip slot 32, which is returned from the chip slot 13 with the chip in the delivery chip slot 32, with the cleaning chip slot 14 of the idle (non-working) cleaning device 1-5.

[0072] ⑧ The chip is transported from the self-distributing chip slot 32 to the cleaning chip slot 14. The chip undergoes magnetic attraction, vibration mixing, barcode recognition by the OpenMV camera, and addition of various reagents within the cleaning apparatus 1-5;

[0073] ⑨ Rotate the detection device 1-6 so that the support block 22 is aligned with the cleaning chip slot 14 on the cleaning device 1-5;

[0074] ⑩ Open the first door 18, and the chip enters the chip detection slot 28 of the detection device 1-6. Close the first door 18 and the second door 19, and then detect the chip.

[0075] ⑪ Open the second hatch 19, rotate the chip detection slot 28 so that the chip faces down and discard it, allowing the chip that has completed the detection to fall out of the hatch 19. Close the second hatch 19 and rotate the chip detection slot 28 back to the initial position.

[0076] This process is repeated to complete the detection of multiple chips and output the detection data.

[0077] The above description is merely an embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural or procedural transformations made based on the content of the present invention specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of the present invention.

Claims

1. A biochip detection system, comprising a delivery device (1-3), a cleaning device (1-5), and a detection device (1-6), characterized in that, It also includes a chip loading compartment (1-1) and a processing device (1-2). The delivery device (1-3) is a rotatable disc with multiple chip delivery slots (32) pointing towards the center. The chip delivery slots (32) are connected at both ends along the radial direction of the disc. The cleaning device (1-5) has cleaning chip slots (14). The cleaning device (1-5) is located in the inner circle of the disc and has multiple cleaning chip slots (14) evenly distributed. Each cleaning chip slot (14) is positioned opposite any of the chip delivery slots (32). The detection device (1-6) is located at the center of the delivery device (1-3) and is rotatable. A first door (18) is provided on one side of the detection device (1-6). The rotation of the detection device (1-6) aligns the first door (18) with any of the cleaning chip slots (14). The chip loading chamber (1-1) forms a cavity in the X direction that can accommodate multiple biochips, and the cavity has an outlet (31) on one side in the Y direction; the processing device (1-2) is provided with a channel for placing biochips, and the channel is connected to the outlet (31) and a chip delivery slot (32).

2. The biochip detection system according to claim 1, characterized in that, The chip loading compartment (1-1) includes a first baffle (3), a second baffle (9), a first base plate (4), a flat push plate (2), a stop block (7), and a reader (11) for identifying barcodes on biochips. The first baffle (3) and the second baffle (9) are spaced apart in the Y direction. The first base plate (4) connects the first baffle (3) and the second baffle (9). The inner surfaces of the first baffle (3) and the second baffle (9) and the upper surface of the first base plate (4) form the cavity. The flat push plate (2) is located in the cavity and extends and retracts in the X direction. The stop block (7) is located opposite to the flat push plate (2) in the cavity. The outlet (31) is located on the second baffle (9), and the inner surface of the stop block (7) forms one side of the outlet (31). The reader (11) is located near the stop block (7) and is positioned directly opposite the cavity.

3. The biochip detection system according to claim 1, characterized in that, The processing device (1-2) extends along the Y direction, and a plurality of sample dispensing devices (6) are provided above the processing device (1-2). The sample dispensing devices (6) extend vertically in the Z direction. A recognizer (11) and a laser (5) are provided on the side of the processing device (1-2). The recognizer (11) and the laser (5) are both facing the processing device (1-2) in the X direction. The number of the recognizers (11) corresponds to the number of the sample dispensing devices (6).

4. The biochip detection system according to claim 3, characterized in that, The processing device (1-2) includes a first side plate (24), a second side plate (23), and a second bottom plate (8). The first side plate (24) and the second side plate (23) are spaced apart in the X direction. The second bottom plate (8) connects the first side plate (24) and the second side plate (23). The inner surfaces of the first side plate (24) and the second side plate (23) and the upper surface of the second bottom plate (8) form a channel for placing a biochip. The identifier (11) and the laser (5) are positioned opposite the channel.

5. The biochip detection system according to claim 1, characterized in that, It also includes a magnetic bead adding device (1-4), which includes a magnetic bead chip slot (13), which is positioned opposite the delivery chip slot (32), and the magnetic bead chip slot (13) and the delivery chip slot (32) are at the same height in the Z direction; an ultrasonic probe (12) and a recognizer (11) are provided on the side of the magnetic bead chip slot (13), and the ultrasonic probe (12) and the recognizer (11) are positioned opposite the delivery chip slot (32); a sample adding device (6) that extends vertically in the Z direction is provided above the magnetic bead chip slot (13).

6. The biochip detection system according to claim 1, characterized in that, The cleaning device (1-5) includes a cleaning chip slot (14), a vibration motor (26), and a magnet (27). The cleaning chip slot (14) is positioned opposite the delivery chip slot (32), and the cleaning chip slot (14) and the delivery chip slot (32) are at the same height in the Z direction. The vibration motor (26) is located at the bottom of the cleaning chip slot (14), and the magnet (27) is located on the side wall of the cleaning chip slot (14). An identifier (11) is provided on the side of the cleaning chip slot (14), and a vertically telescopic sample feeding device (6) is provided above the cleaning chip slot (14). The identifier (11) is positioned opposite the cleaning chip slot (14).

7. The biochip detection system according to claim 1, characterized in that, The detection device (1-6) is a sealed cavity formed by a detection top plate (17), a detection bottom plate (20) and four detection side plates. One of the detection side plates is provided with a feed inlet (33). The first door (18) is provided on the detection side plate and can open or close the feed inlet (33). The detection bottom plate (20) is provided with a discharge port (34). The detection bottom plate (20) is provided with a second door (19) that can open or close the discharge port (34). The feed inlet (33) is located directly opposite the cleaning device (1-5).

8. The biochip detection system according to claim 7, characterized in that, The detection device (1-6) further includes a detection chip slot (28), which is rotatably installed in the sealed cavity. One end of the detection chip slot (28) is connected to the feed port (33). The detection side plate with the feed port (33) is provided with a support block (22). One end of the support block (22) protrudes from the outside of the detection side plate, and the other end is connected to the detection chip slot (28) from the feed port (33).

9. The biochip detection system according to claim 1, characterized in that, The detection device (1-6) extends vertically through the delivery device (1-3), and a second door (19) is provided at the bottom of the detection device (1-6).

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